LOCUS       NZ_LS483389            24230 bp    DNA     circular CON 13-FEB-2024
DEFINITION  Streptococcus pyogenes strain NCTC10879 chromosome 1, complete
            sequence.
ACCESSION   NZ_LS483389
VERSION     NZ_LS483389.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Doyle,S.
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 01:12:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,924
            CDSs (total)                      :: 1,835
            Genes (coding)                    :: 1,780
            CDSs (with protein)               :: 1,780
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 36 of 55
            Pseudo Genes (incomplete)         :: 21 of 55
            Pseudo Genes (internal stop)      :: 26 of 55
            Pseudo Genes (multiple problems)  :: 22 of 55
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:51:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 987825
            Orig. end                         :: 1012055
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LS483389.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24230
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24230
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24230
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14230](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14230)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(205..996)
                     /gene="folP"
                     /locus_tag="DQM81_RS05155"
                     /old_locus_tag="NCTC10879_01030"
     CDS             complement(205..996)
                     /EC_number="2.5.1.15"
                     /GO_function="GO:0004156 - dihydropteroate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="folP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528620.1"
                     /locus_tag="DQM81_RS05155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01030"
                     /product="dihydropteroate synthase"
                     /protein_id="WP_053308345.1"
                     /transl_table=11
                     /translation="MKIGRFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMI
                     ADGAKIIDVGGESTRPGCLFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARAAL
                     EAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRAQAA
                     LDAGVPKNNIWIDPGFGFAKSVQQNMELLKGLDRVCQLGYPVLFGISRKRVVDALLGGN
                     TKAKERDGATAALSAYALGKGCQIVRVHDVKANQDIVAVLS"
     gene            complement(1005..1571)
                     /gene="folE"
                     /locus_tag="DQM81_RS05160"
                     /old_locus_tag="NCTC10879_01031"
     CDS             complement(1005..1571)
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GTP_cyclohydroI"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989871.1"
                     /locus_tag="DQM81_RS05160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01031"
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="WP_063629281.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 2e-76, bitscore:
                     252.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFLG
                     LGKDPKEEFTAVFKEQHEDVVIVKDVSFYSICEHHLVPFYGKAHIAYLPSDGRVTGLSK
                     LARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHMCMTMRGIKKPGSKTI
                     TTTARGLYKESRAERQEVISLMIKD"
     gene            complement(1625..2902)
                     /locus_tag="DQM81_RS05165"
                     /old_locus_tag="NCTC10879_01032"
     CDS             complement(1625..2902)
                     /EC_number="6.3.2.-"
                     /GO_function="GO:0004326 - tetrahydrofolylpolyglutamate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008841 - dihydrofolate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995327.1"
                     /locus_tag="DQM81_RS05165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01032"
                     /product="folylpolyglutamate synthase/dihydrofolate
                     synthase family protein"
                     /protein_id="WP_053308344.1"
                     /transl_table=11
                     /translation="MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIV
                     GTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRIRP
                     LTERLVQETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMVVV
                     CPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWE
                     WQEQFQMAENASGYRFTSPLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTPD
                     HIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAVLKNNYNDKKLHILFGAIDTK
                     PIVDMLVALEQIGDLQVTSFHYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVI
                     TGSLYFISEIRKYWEKHIEKSVLLTH"
     gene            3233..4195
                     /locus_tag="DQM81_RS05170"
                     /old_locus_tag="NCTC10879_01033"
     CDS             3233..4195
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407556.1"
                     /locus_tag="DQM81_RS05170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01033"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_063629246.1"
                     /transl_table=11
                     /translation="MNNRHKRRQKRKAFTLINLILLFACILGLTLIFYLYQGSNKFGLS
                     DVSQFVPKISLFHHKKMAKKETTKLKKTHFNSSKSQKKAHSKLTWTKQETPVKIPILMY
                     HAIHVMSPEETANANLIVNPDLFDQQLQKMKDEGYYFLSPEEVYRALSNNELPAKKVVW
                     LTFDDSMIDFYNVAYPILKKYDAKATNNVITGLTEIGSAANLTLKQMKEMKQFGMSFQD
                     HTVNHPDLEQASPDVQTTEMKDSKDYLDKQLNQNTIAIAYPSGRYNDTTLQIAARLNYK
                     LGVTTNEGIASAANGLLSLNRIRILPNMSPENLLQTIEP"
     gene            complement(4312..5547)
                     /gene="pbp3"
                     /locus_tag="DQM81_RS05175"
                     /old_locus_tag="NCTC10879_01034"
     CDS             complement(4312..5547)
                     /EC_number="3.4.16.4"
                     /codon_start=1
                     /gene="pbp3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922278.1"
                     /locus_tag="DQM81_RS05175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01034"
                     /product="D-alanyl-D-alanine carboxypeptidase PBP3"
                     /protein_id="WP_111688295.1"
                     /transl_table=11
                     /translation="MIKRWVILFFMVLTCSGFGKTVLAADFQVGAEHAIVVEADSGRVL
                     YEKNAKTPDAIASLTKLVTAYLVLDKVKSGQLQLSDQVNLSDYAFELTKDRSLSNVPFD
                     KKTYSVQDLLTATLVASSNSAAIALAEKVAGSELHFVNQMREQLSHWGITSGKILNASG
                     LPNEVLKDNRYPGSALEEENTLSAQDVAVVTMHLLEDFPEILEITKQTEVNFAGNSIKS
                     FNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENGMRVITVILNADGSDKNQNTRF
                     EQANRLLDYVARTYCRRKILKKGSLVLERPLPIQDGQVKELPVSVAEDVTIILQQGEQV
                     PKPKQFMISETSLLAPITKGEVVAYLTSPRITDQSVRYLKEPKRIPLKASQSLKKASDL
                     QLWWRDFLEKRR"
     gene            complement(5705..6892)
                     /locus_tag="DQM81_RS05180"
                     /pseudo=""
     CDS             complement(5705..6892)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002943304.1"
                     /locus_tag="DQM81_RS05180"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTIKNQKKYKGVYCDKNGKIFYQADLGVDPVTGKRVQKKARKN"
     gene            complement(6849..7115)
                     /locus_tag="DQM81_RS05185"
                     /pseudo=""
     CDS             complement(6849..7115)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001828144.1"
                     /locus_tag="DQM81_RS05185"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF3173 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNIGFLEHTARNIIREAKRIAIKKLKKLANLNKMRYN"
     misc_feature    7129..7144
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            complement(7416..7634)
                     /locus_tag="DQM81_RS05195"
                     /old_locus_tag="NCTC10879_01039"
     CDS             complement(7416..7634)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984785.1"
                     /locus_tag="DQM81_RS05195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01039"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_002989884.1"
                     /transl_table=11
                     /translation="MYPRIRNLREDNDFTQKFVANLLSFSHANYAKIERGEVALMADVL
                     VQFSKLYNVSIDYLLGQTDYPYRFHNK"
     misc_feature    7593..7604
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     gene            complement(7826..8548)
                     /locus_tag="DQM81_RS05200"
                     /old_locus_tag="NCTC10879_01040"
     CDS             complement(7826..8548)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922276.1"
                     /locus_tag="DQM81_RS05200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01040"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_011528613.1"
                     /transl_table=11
                     /translation="MKSYLCSNFLKIKNTSYLLIHILAALLFPLLLFFYWSQRGGLQSR
                     TVLFSYFQIVGVLLPFVASIVCIQLKNLEESSGKYKYLLGYSQSNYKPFIVELVFLWLC
                     YCIVLIISITIFILLLKTIGINVSLRLLILNSLIYIIFAYVTYLINHIISYIFSTGVAL
                     GISMVGVIAAAFCETSLGDKVWFLIPWAWLLRISDTLYNQQKMAIVPLIVIFFVSCTVA
                     LLHIRIFKSWNQDCLTSS"
     gene            complement(8551..9300)
                     /locus_tag="DQM81_RS05205"
                     /old_locus_tag="NCTC10879_01041"
     CDS             complement(8551..9300)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984791.1"
                     /locus_tag="DQM81_RS05205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01041"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_031488307.1"
                     /transl_table=11
                     /translation="MVQIFLSNLLKIKNTSISKLILIFPIICVMLSLLFSALGGESILR
                     LTAETTVNQWGVIWINVIIAVNSGLLNKLELDSNKYSVFLSRDVDLKKVEYARVLLIAL
                     INLIISMILSLMLIVISFVLPTPSLISIGRILLTILLIWLTTLWQIPFILWLSRKINVY
                     FAMIINIISPLIIGTSFSLLNKWYLFPYDWSLKLLEPMTRMRINSIPFGAEFVPDYSQI
                     FISLFLGIAFFILLTNLFAISFKKQVK"
     gene            complement(9306..9995)
                     /locus_tag="DQM81_RS05210"
                     /old_locus_tag="NCTC10879_01042"
     CDS             complement(9306..9995)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922274.1"
                     /locus_tag="DQM81_RS05210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01042"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_021775230.1"
                     /transl_table=11
                     /translation="MLKIQNLKKSYGKRTILNNVNMNIPKGKVYALIGPNGAGKSTIMK
                     ILTGLVSKTSGSIIFEGREWSRRDLRKIGSIIEEPPLYKNLSAYDNMKVVTTMLGVSES
                     TILPLLNKVGLGDIDKRPVKQFSLGMKQRLGIAISLINSPKLLILDEPTNGLDPIGIQE
                     LREIIESFKSEGMTIMISSHILSEVEHLADFIGFIYEGKIVLEKEYDGSENLEELFNNQ
                     ILFEKRR"
     gene            complement(10001..12967)
                     /locus_tag="DQM81_RS05215"
                     /old_locus_tag="NCTC10879_01043"
     CDS             complement(10001..12967)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528611.1"
                     /locus_tag="DQM81_RS05215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01043"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_047235299.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.8e-90, bitscore:
                     299.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.7e-11,
                     bitscore: 41.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.9e-14, bitscore:
                     50.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKVFPTGMIRIPLQKQEFYNKDYEDLINDKVFMEQLLVASPSLY
                     DSVIDFDKCNEKKKQNVKVSLNSYSKRAAFRTTPFGIFTAINTVDLTKGTTSNVQKVSF
                     IKKAVPDYSWIYSLVKSYEISNLEKLSLKINTAAFTQGDRYVLPFTVNESEEDRNISFS
                     KPIKLLVEKCKTRYIKYEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPPICN
                     INSLDYLLSKLEEGTLCTDLTTLKKMIEDYNDLNIGEGRDLLLQIFDKMESIYKYDNGG
                     NYLKVDSLAEYEGGFNILSETARESIERLAEMFVKLNTNVKRRGGRKNSLEEYQLKFIG
                     KYGENCSIPFVEVINKDAGIGFPEYYKGGEGEAIELSDPIMQMFEKKYEEALLNGGHIE
                     FYSKDLDDFQTDQSNSLDSFELNFNIKIINNDVKLYLGANIGSGQAGRSFGRFYGLSET
                     VRETIKNLNHQNNTNVELSFVPKQIRLANVIQNYSDESYNTSFFTTSWDSENELRLEDI
                     YIRYSDGKFHFTTIDGKNELKFTMNNMLNSDSQSRVLRLLVDLSEFEYGLSHWSLFPWD
                     ILAQERVYIPEILFEDITIATAQWNLSVIREEIIHQKIFTGKKDIFNKFRKTYKIPKDI
                     ILKYADNELRLDLSIDSDLEILFKNINKYRFVSLRGIEQGESIFKDNLGNYNTEIVVPI
                     LKESNGINNTNDNVQFKNEVKKIYLPFCDWLFFKFYGPKERQEELLNNWKKFWLNLPSE
                     LFSQSNMFYMRYNDTNDHIRIRINCDSIENNFSLYLSVVQDLLPQLIESCIISDIEVSS
                     YKPEVNRYGGPHLISYAEEIFCKESILFLNNTIEFSDDERLVCATYLVLYYLNHFFKDK
                     ETRRSFLFENYTGKYKKDFKNLPIDLPIEYMKSLNGVTSALDRYDFFQEMDRYLMSYMK
                     EYNRFGGTNDIYNTKFNLVGSFLHLSMNRLNGIDREFEEKVYCFAYYTLNAQQYIEWE"
     aSDomain        complement(12311..12565)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DQM81_RS05215_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.60E-13"
                     /identifier="RREFam001.1"
                     /label="DQM81_RS05215"
                     /locus_tag="DQM81_RS05215"
                     /protein_end="219"
                     /protein_start="134"
                     /score="41.5"
                     /tool="antismash"
                     /translation="NTAAFTQGDRYVLPFTVNESEEDRNISFSKPIKLLVEKCKTRYIK
                     YEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPP"
     gene            complement(12986..14230)
                     /locus_tag="DQM81_RS05220"
                     /old_locus_tag="NCTC10879_01044"
     CDS             complement(12986..14230)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989896.1"
                     /locus_tag="DQM81_RS05220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01044"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_038434072.1"
                     /sec_met_domain="LANC_like (E-value: 2.1e-76, bitscore:
                     253.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPQIKQIVDYIADSFINYEQIVAESENKVLINIESKYRNTFFDK
                     SLSHGVPSLILMYSSLYKVTKDERYLTFSNIYVEKLVDIISRDGIESPSLYAGTAGIAL
                     AIKEASISGKYCPKLLSSLNCLLKEQIKDKLVVSFSNIEKGIIEPYDYDMVNGFSGITN
                     YLLLEQEFFSVELNQIGNYLLKYIETILNKVTNCSEDREAEFDLGIAHGITGPMLTLAK
                     LKSEKILSVEVGDILNKAINLMFLFRRDDKLWPGKIYTSNILDLDLNYLPTRMAWCYGT
                     PGTAVALFKMCQLIDLNFIDDINESLIAQMRSSDKNVYSLTMCHGLAGVTFIYDLIGKN
                     YSSERLTRFAEELRQQIITSFSTTKVFGYTDREKFGEIEVELESIGILQGVSGIVLFLL
                     NPYSDEELLWQRIFI"
     gene            complement(14214..16004)
                     /locus_tag="DQM81_RS05225"
                     /old_locus_tag="NCTC10879_01045"
     CDS             complement(14214..16004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418808.1"
                     /locus_tag="DQM81_RS05225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01045"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_038434071.1"
                     /transl_table=11
                     /translation="MIKAQLKNLIKTIHLVKEAGFSLLVFSIAISLFQGILPIFSMLLV
                     QKMLNIITTDIKNFHTLMIAFISYIALTLLTIIIGEVDSYIDTKLQILLHYKMNHLVMQ
                     KTVKLTLAEFETPEIYDDITRIQNQISYKPFQIYKSIISVLSSLVSLISSFVILLNWKI
                     SIFPLLLILPIVSIYIYLKISKNEFEILYKRSSDERANWYISHLLTHDFAVKELRLGTL
                     ESYFLKKYDKNNQLFINQENSINRSKMKYGIVLGVLEIAIQSIIMFLAVREAFLGILLV
                     GNVTTFIRSLSTMQTSTQNIVNNIYSFYNGSLYMELLYDFTHDELVHNPIIESTVDTIQ
                     SVEFERVSFSYNGKDNVINDISFSIKAGERLAIVGENGSGKSTIFKLACGLYDNYEGNI
                     YINGINLRSIQKKSYYKRISALFQDFLKYELTLRENVGLGELSKLYSDEDLISALKYTG
                     VDSIFYFNQEKLNQIDLEQQLGNWFEDGRQLSGGQWQKIALSRVYLKEADCYLLDEPSS
                     ALDPESETKIFKTFFELSQNKIGIFITHKPSITQSVNKILYLDNGCIAETGSFADLNIK
                     GMKFKNLLDKEIGATYDTSN"
     gene            complement(16119..16259)
                     /locus_tag="DQM81_RS05230"
                     /old_locus_tag="NCTC10879_01046"
     CDS             complement(16119..16259)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528609.1"
                     /locus_tag="DQM81_RS05230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01046"
                     /product="lantibiotic streptin"
                     /protein_id="WP_002984803.1"
                     /sec_met_domain="TIGR03731 (E-value: 8.6e-09, bitscore:
                     32.1, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNTIKDFDLDLKTNKKDTATPYVGSRYLCTPGSCWKLVCFTTTV
                     K"
     misc_feature    16372..16387
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.51"
                     /tool="antismash"
     gene            complement(16416..17762)
                     /locus_tag="DQM81_RS05235"
                     /old_locus_tag="NCTC10879_01047"
     CDS             complement(16416..17762)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984805.1"
                     /locus_tag="DQM81_RS05235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01047"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_002984805.1"
                     /transl_table=11
                     /translation="MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSH
                     NVGEEFYIKDKQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVAEEKN
                     NLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIVVAL
                     TRFVKEISLNFKEIKKLANKMGIEVLSENENYSKIIEFDDILRTLHIKGDNLKSLIERE
                     ILEKQDLSFQIAALSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYF
                     NSLISYTRMLSEDRSVKLILVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEE
                     NLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFY
                     TEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI"
     gene            complement(17755..18441)
                     /locus_tag="DQM81_RS05240"
                     /old_locus_tag="NCTC10879_01048"
     CDS             complement(17755..18441)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373772.1"
                     /locus_tag="DQM81_RS05240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01048"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002984807.1"
                     /transl_table=11
                     /translation="MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKG
                     YDLILLDIMMPNISGTEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIVKPFS
                     LKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYREYE
                     ILELLSRHPYKVFTKEEIYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGI
                     GYKWDV"
     gene            complement(18592..>20085)
                     /locus_tag="DQM81_RS10005"
                     /pseudo=""
     CDS             complement(18592..>20085)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294852.1"
                     /locus_tag="DQM81_RS10005"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="SAG1250 family conjugative relaxase"
                     /pseudo=""
                     /transl_table=11
                     /translation="TDKNHTHNHIQSAPLTVIQIKN"
     gene            complement(<20076..20401)
                     /gene="dcm"
                     /locus_tag="DQM81_RS05260"
                     /old_locus_tag="NCTC10879_01052"
                     /pseudo=""
     CDS             complement(<20076..20401)
                     /GO_function="GO:0003886 - DNA
                     (cytosine-5-)-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="dcm"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000670032.1"
                     /locus_tag="DQM81_RS05260"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="NCTC10879_01052"
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKFLDLFAGIGGFRLGLINQCHECIGFCEIDKFARQSYKAIYETE
                     GEIEFHDIRQVTDQDFRQLRGQVDIICGGFSLVKHFHSQADDWDLRGLGELSSLRLLER
                     PNR"
     gene            complement(20581..>21180)
                     /locus_tag="DQM81_RS09875"
                     /pseudo=""
     CDS             complement(20581..>21180)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /locus_tag="DQM81_RS09875"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="replication initiator protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AIYLIYSNSK"
     gene            complement(21479..21844)
                     /gene="rplL"
                     /locus_tag="DQM81_RS05270"
     CDS             complement(21479..21844)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /locus_tag="DQM81_RS05270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="WP_002984819.1"
                     /transl_table=11
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAAAAAG
                     GAEEAAKDSFDVELTSAGDKKVGVIKAVREITGLGLKEAKGLVDGAPANVKEGVAAAEA
                     EEIKAKLEEAGATITLK"
     gene            complement(21909..22409)
                     /gene="rplJ"
                     /locus_tag="DQM81_RS05275"
                     /old_locus_tag="NCTC10879_01056"
     CDS             complement(21909..22409)
                     /GO_component="GO:0015934 - large ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012658294.1"
                     /locus_tag="DQM81_RS05275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01056"
                     /product="50S ribosomal protein L10"
                     /protein_id="WP_021775235.1"
                     /transl_table=11
                     /translation="MSEAIIAKKAEQVELIAEKMKAAASIVVVDSRGLTVDQDTVLRRS
                     LRESGVEFKVIKNSILTRAAEKAGLGELKDVFVGPSAVAFSNEDVIAPAKVINDFTKTA
                     DALEIKGGAIEGAVSSKEEIQALATLPNREGMLSMLLSVLQAPVRNVAYAVKAVAENKE
                     GAA"
     misc_feature    complement(22438..22573)
                     /db_xref="RFAM:RF00557"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
     gene            22744..24120
                     /gene="mnmE"
                     /locus_tag="DQM81_RS05280"
                     /old_locus_tag="NCTC10879_01058"
     CDS             22744..24120
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="mnmE"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002888396.1"
                     /locus_tag="DQM81_RS05280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_01058"
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="WP_111688296.1"
                     /transl_table=11
                     /translation="MSITKEFDTITAISTPLGEGAIGIVRLSGTDALAIAQSVFKGKNL
                     EQVASHTINYGHIIDPKTGTIIDEVMVSVMLAPKTFTRENVVEINTHGGIAVTNGILQL
                     LIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMTIAVKQLDGSLSQLI
                     NDTRQEILNTLAQVEVNIDYPEYDDVEEMTTALLREKTQEFQSLLENLLRTAKRGKILR
                     EGLSTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNIKGVPLKLVDTAG
                     IRETDDLVEQIGVERSKKALQEADLVLLVLNASEKLTDQDRALLNLSQDSNRIILLNKT
                     DLEQKIELEQLPDDYIPISVLTNQNINLIEDRINQLFFDNAGLVEQDATYLSNARHISL
                     IEKAVQSLEAVNDGLALGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLFSQFCLGK
                     "
ORIGIN
        1 taactgacgg acactgtcaa acaccatccc gtaatggacc gtatctgtta attggtctga
       61 caaagaagct gcttgcaaat cgactgacaa ttctaaatca accagaaaaa tttgcccaag
      121 ggtctgttct tctttaaagg ctccatggta gccataaaaa cggcaacctt ctaatacgat
      181 tttatccata agtcctcaca tcaactagct caaaacagcc acaatgtctt gattagcctt
      241 gacatcatgc acccgtacaa tctgacagcc ttttccaagg gcataagcag acaaggctgc
      301 tgtcgctccg tctcgctctt tagctttggt gttgccgcct aacaaggcat ctacgacacg
      361 ctttctcgaa ataccaaaca agacaggata acccaactga cagacgcggt ccaatccttt
      421 taataactcc atattctgtt gaacagattt ggcaaatcca aatcctggat caatccaaat
      481 attgtttttt ggcacgccag catcaagagc tgcttgtgct ctattgccta gaaaatcaca
      541 aacgtcttgt gttacctctt gataaacttc ttcgtcttgg ttatgcatca agatgatagg
      601 cgcatcgtac tcggctgcta aggcaaacat ttgaccgtcg tacaaacctg cccaaacatc
      661 attgagaata tcggcacccg cctctaaagc tgctctagct gtttcggttt tataggtatc
      721 aatgctgatt agaatatcat agttttcttt gatggccttg atcacaggaa ccacccggtc
      781 aatttcatcg gtagcgctta caaataggca acctggacgt gttgattctc caccaacgtc
      841 gatgatttta gcaccatcag caatcatttg ctcaacgtga tctaatgctt tttgcacagt
      901 agtgtaagac cccccatctg aaaaagaatc tggagtcaca tttaaaatcc ccatgatagc
      961 cgcattgccc tcaatcacaa accttccaat tttcataagt cctcctaatc ttttatcatt
     1021 agagaaataa cttcttgcct ctcagcacga ctttccttgt ataagcctct ggcagtggtg
     1081 gtaatggttt tactacctgg ctttttgatg cctcgcatgg tcatgcacat gtgctctgct
     1141 tctaccataa ctaaagtccc tttaggattg agggcttcaa ctaaagcatc cgctatttga
     1201 gaggtcaaac gctcttggag ttgaggtcgt ttactagcta cttcaactgc tcgcgctaat
     1261 ttactcaaac ctgttactcg accatcactt ggcaagtaag cgatatgagc cttgccataa
     1321 aaaggaacta agtggtgttc acatatagaa taaaaactaa cgtctttgac aatcaccaca
     1381 tcctcatgtt gttctttaaa gacagccgta aactcctctt taggatcctt tcccagtccc
     1441 aaaaacatct ccgcatacat tttagcaacc cgtttaggcg tgtcaagaag accttctcga
     1501 tttggatttt caccaatagc ctctaaaaac tgataaatgg ctgcttctgc tttttcctta
     1561 ttaatagaca ttagtctttc ccttttcatt agttttttcc ttttcctttt cattttctct
     1621 ttttttaatg ggttaaaaga acgctttttt caatatgttt ttcccaatac tttctaattt
     1681 ctgaaataaa atatagtgac cctgtaatca cgaaaaagtc atctgcttta gcatgcttac
     1741 gcaaggccaa gaaatctttg aaatcagcaa ccctaccaaa acgttctggg tatttttcca
     1801 atggataggc gttagggtaa tgaaagctag taacctgcaa gtcacctatt tgctcaagag
     1861 caaccaacat atctacaata ggcttggtgt cgatcgcacc aaacaaaata tgaagctttt
     1921 tatcattgta gttatttttt aagacggcta ccaaagcagc aacgctttca ttgttatgag
     1981 ctccatcaat cattagattt ggtgctaata attcggtacg gcctagccac aaactatttg
     2041 ccagaccttc ccttatatga tctggagtta gcctaggata gcggtctttc aaggttaagc
     2101 aagtcataat agctaaagct gcattagaca cttggtggtg tcctggcata gcgatgtgaa
     2161 tatctgaaat aactcctaaa ggactagtaa aacgatagcc agatgcgttc tcagccattt
     2221 gaaactgctc ttgccattcc cagattgaag caccaacctg ctcagctttt gttaaaaaaa
     2281 cctctcgagc tgacgggttt tcaacggcaa aaacaagggt ctcgccccct tctaaaacac
     2341 cagctttttg ggcggcaata tcagcgtaag tctctcccaa aatagcttgg tgatctaaac
     2401 caattgaggg acagaccaca accattgctt gaaaaacatt ggtcgaatca taaagaccgc
     2461 caaggcctgc ttcaataata gcaatatcta caggatgcat atcaccaaaa tagaggaaca
     2521 tgatcaaagt aatcacttca aattcagtta cctctccaaa atcagtctct tgaactagac
     2581 gctctgtcaa aggacgaata cgattagcag caataaccaa atctttttct gaaatcattc
     2641 gaccatttat gctaatacgt tctttgaaat ccataatata aggagaggta aaggtcccca
     2701 cttcataacc agctgtcgta aagatgtgtt gtaaatgatt aaccgtggaa ccttttccgt
     2761 tagttccaac gatatgcact cccttgacat ttttttgggg atttcctaac tgtccaagaa
     2821 cccaaagcat acgttttaag cctggcttga tgccgaaaac taagtgatca tgaatccatt
     2881 ctagagtctc ttcataagtc atttcatacc tcacatctat ctttagtata ccatatataa
     2941 aaaaaagtga cagcagataa cctagagtag tacccttttt ttattatcct caccaaacac
     3001 tcaaataagt tctaaagtac actacacttt tatcttcatt gcttttttta cgtgataaga
     3061 ataccagccc cacatagtct ttgctacctc ctaaagtatt atctgtgaca atattttttt
     3121 tactccttaa tacacgttct tccaaaaaac aagaaaaaag gctgacttca agccttcttt
     3181 tctctaaaaa atgttacaat agaggtactt atatcaaaaa aaggagcaag taatgaacaa
     3241 tagacataaa cggcgccaaa aaagaaaagc cttcactctc attaacctta tactattatt
     3301 tgcctgcatt cttggtttga ccctcatttt ctatttatat caagggtcta acaaattcgg
     3361 cttgtcagat gtctctcaat ttgtacctaa aataagtctt tttcatcaca aaaagatggc
     3421 aaaaaaagaa acgacaaaac ttaagaagac tcatttcaat tcctcaaaat ctcaaaaaaa
     3481 ggcccattct aaattaactt ggaccaagca agaaacacct gtcaagatcc caattttaat
     3541 gtatcatgct attcatgtaa tgtcccctga agagacggca aatgctaatt tgattgtcaa
     3601 cccagatctc tttgatcaac aacttcaaaa aatgaaagac gagggctact attttttgag
     3661 tcctgaagag gtctaccgcg ctctttcaaa taatgaattg cctgctaaaa aagttgtatg
     3721 gctaacattt gatgacagta tgattgattt ctacaacgtt gcttacccaa tcttaaaaaa
     3781 atatgatgct aaagccacca ataatgttat tacaggacta accgaaatag gaagcgctgc
     3841 caatctgact cttaaacaga tgaaagaaat gaaacaattc ggtatgtctt tccaagatca
     3901 tacagtgaat catcctgatc tagagcaggc tagtcctgat gttcaaacaa ctgaaatgaa
     3961 agattcaaag gactatcttg ataagcaatt aaaccaaaac actattgcca ttgcttatcc
     4021 atctggtaga tataatgaca ctaccttaca aattgcagct agacttaact ataaattagg
     4081 tgttaccact aacgaaggaa tagctagcgc ggctaatgga cttctttctc ttaaccggat
     4141 tcgtatcctc ccaaacatga gtccggaaaa tcttttacaa acaatagaac catagcatca
     4201 atttttttat cattccaaat catactcact gtaaactaaa aagacagtta tgaaaaaatt
     4261 ctttcataac tgtctttttt tgattgtttt aaaattattt tattcttatc tttaacgtct
     4321 tttttcaaga aaatctcgcc accacagctg taagtcagag gcttttttta gagattggct
     4381 agctttaaga ggaatacgct taggttcctt taaatacctc actgactgat ctgttattct
     4441 tggagacgtc aaataagcaa ccacttcacc tttagtaatc ggtgctagta aagaagtctc
     4501 tgatatcata aattgtttag gtttgggaac ttgttcaccc tgttgcaaaa tgatggttac
     4561 atcttcggca acggataccg gtagttcttt tacttggcca tcttgaatag ggagcggccg
     4621 ctccaagaca agacttcctt ttttaagaat cttacgacga caataagttc tagccacata
     4681 gtccaacaaa cgatttgctt gctcaaaccg cgtgttttgg tttttatcag atccatcggc
     4741 atttagaata acggtaatca ctcgcatacc attttcaata gaagttacca caagacaatg
     4801 acctgctaag tctgttgtcc cagtctttaa accatccact cctgctctac ccttagccat
     4861 acctggtaag agttgattaa aacttttaat agaattgcca gcaaaattaa cttctgtttg
     4921 tttggtgatc tctaaaatct caggaaaatc ttctaacaaa tgcatcgtca caactgcaac
     4981 atcttgagca ctcaaggtat tttcttcttc caacgcagaa ccaggataac gattatcctt
     5041 taacacctca tttggcagac ctgaagcgtt gaggatttta ccagaagtaa tcccccaatg
     5101 agatagctgt tctctcattt gatttacaaa atgaagctct gaacccgcca ctttttcggc
     5161 taacgcaata gcagcgctat ttgagcttgc taccaaagta gctgtcaaca ggtcttgaac
     5221 tgaataagtt tttttgtcaa aaggtacatt acttaaagac ctatcttttg ttaactcgaa
     5281 ggcataatct gagagattaa cttgatctga taattgcagc tggcctgatt taaccttatc
     5341 taaaaccaga taagccgtca ccaatttggt caaagaggca atagcatctg gcgttttagc
     5401 gtttttctca tacagaactc tcccagagtc tgcctctacg acaatcgcat gttctgctcc
     5461 cacttgaaaa tcagctgcga gaactgtttt accaaaccct gaacaagtta ataccataaa
     5521 aaaaaggata acccaccttt ttatcattat atctttcata gttactatta taacaaaaat
     5581 tctcagaaat ttggaaggaa gtatagtggc acacaccttt agtagcttaa acaagctcat
     5641 aaagcaagta ccctgtaaca ataacacatc ctgttatatg ggcgatataa taagcttcgt
     5701 tatatcaatt agttatttgg caggaatttt ggtataaaat ggaatctaat cctgaactta
     5761 ttacattttg ggttatttct tcagatactg ttttatctaa tgcattaaat cagtgactat
     5821 atgtattcaa agttgtagac ttatcagcat gtcccataca ctttgcaacg tacagaatgt
     5881 cttttttcaa aacattaata agataggaag cataactatg tcgcaatcct tttccagtta
     5941 ttacgggaac tccaatactt tgagctttgt gcttaataac tcgacaaatc gttgatttac
     6001 aaaatggttc accaaaccgt gaaataatga aatctgtgtc agtattgact acttgatttc
     6061 ttctccaatt ttccaatact actattgtca catcatctaa ctcaataaga cgttctcctg
     6121 ctggcgtttt tgtttggtct ttacgatacc aatttccatt ttcatccttt tccaaggttg
     6181 tatgaacttt caagaatttt tgttcgaaat cgatattttc ccatcataat gataaacctt
     6241 cacttacacg aacacctgtc atataatata gccaaatagt tgtaaatctt tgtagctctt
     6301 cataatcttg caaatcaaac gattttataa aattctgaaa ctcaatataa gtccaaaatg
     6361 gagtgtcggg atgtttccct ttaggattat ccaaagcctt acatggcact tttgaaatat
     6421 agtctaacct ttcagcatac cccatgcaag ctttgaatcg cgaccataaa ttctttgcat
     6481 aattttcaat aatatgtaaa ctaaaagatt cacaatctca agctgttatt ccctttaaaa
     6541 gtttagaatc aaaatactga ataaataact tatgatgtgg taaggctatt tcataagtta
     6601 cagcctgaac cttttgctta tatgctctta ggtaaatagt attcatatag ttttcaaacg
     6661 atatattgtc attttcaata ctaagattat tactgaactc atacctaatc cgaaccagtt
     6721 catcatacgc ttctttcatt gtaccaaatg gctttccata ctaattcttt ctggctttct
     6781 tttgaactcg tttacctgtt actggatcta caccaagatc agcttgataa aatatcttcc
     6841 cattcttatc acaataaaca cctttgtact ttttttgatt ttttatagtc atctttaatt
     6901 ctcactttct aaactttctt cagagagtag aacacctact aactcttcta caatatcttt
     6961 aggagcaata ccaagtcttc tattgtcaaa gggcgattta cttaattgta ccgcattttg
     7021 ttcaagttcg cgagcttctt caactttttt atagctattc tttttgcttc tctaataata
     7081 tttcttgcag tatgttcgag aaaaccaata ttcatcaagc tttttatatg ttactatttt
     7141 cacacctcca ctcctttcaa aaaaattaca acctccgtgg gtatgactgg ttaaatcact
     7201 catgggaatc tcacccactg gccttttacg ctggcagcct gaacgttcag aagtatcatt
     7261 gtccctattt gtggtcatgg cagatagaga accactctat tttatagcta ataattatcg
     7321 ctcctatcac ggcgtatctc actaaattgc tcgacaaaca agaaagtccc acctcggttt
     7381 attcagttgt caatgaacaa atcaaggcga gacttttatt tattatgaaa acgatacgga
     7441 taatctgttt gccctaataa ataatcaata ctgacgttat agagtttaga aaactgcaca
     7501 agaacatctg ccattaaggc aacctctcct ctctcaattt ttgcataatt tgcatgagag
     7561 aaggaaagta aatttgcaac aaacttttga gtgaaatcgt tatcttctct caaattccta
     7621 atacgcggat acatctaaca ttctcctaat atcagtataa aggagatttg attaaaaaat
     7681 gtttaattgt cctatttgga caagactatt aaatataagc tagtaatcca ttgaaatttt
     7741 atagtcattt tttagttaaa caagttagat agtatttata acttaaaaaa tcatatttat
     7801 tgctaggtaa acaaaataga tgtatttaac tacttgtcaa acagtcttga ttccaacttt
     7861 taaatattcg tatatgaagt aaagctactg tgcatgaaac aaaaaatata acaataagtg
     7921 gaacaattgc cattttctgt tggttatata gagtatctga tattcttaaa agccatgccc
     7981 atggaataag aaaccatacc ttatcaccaa ggctcgtttc acaaaatgct gcagcaataa
     8041 cacctaccat tgaaatacct aatgccacac ctgtactaaa tatatagcta ataatatgat
     8101 tgatcagata ggttacatag gcaaaaatga tataaattaa actattcaaa ataagtagtc
     8161 tgagagatac atttatacca atagttttca ataaaagaat aaatatagta attgaaataa
     8221 ttaatactat acaatagcat aaccatagaa atactaattc tacaataaat ggcttataat
     8281 tcgactgtga ataacccaat aaatatttat attttccaga tgattcttcc aaatttttta
     8341 gttgaatgca cacaatactt gcaacaaaag gaagaagtac acctactatt tgaaagtagg
     8401 agaataatac agtcctgctt tgtaaacctc cacgttgact ccaatagaaa aatagaagta
     8461 agggaaataa tagtgcagct aaaatatgta ttagtaaata tgaagtattt ttgattttta
     8521 aaaaattaga acataaatat gatttcatga ctatttcacc tgttttttga aagagatagc
     8581 aaatagattg gtcagtaaga tgaaaaaagc aattcctagg aacaatgata taaaaatctg
     8641 tgagtagtct ggaacaaact ccgctccaaa aggtatacta tttattctca ttcttgtcat
     8701 tggctcaagc aacttcaacg accaatcata agggaacaaa taccatttat ttaagagaga
     8761 aaaacttgta ccaataatta gtggagatat aatattaata atcatagcaa aatacacatt
     8821 aatttttctt gatagccata aaataaacgg gatttgccat agtgtagtca accaaattaa
     8881 caagatagtt aatagtatcc tacctatact aataagactt ggagtaggta ggacaaaact
     8941 aattacaata agcattaagc ttaaaatcat actaattatt agatttataa gagctatcaa
     9001 tagaactctg gcatattcta ccttttttaa atcaacatcc cttgataaaa aaacagaata
     9061 cttattagaa tctaattcta atttatttaa caaaccagaa tttacagcaa taataacatt
     9121 aatccaaata actccccact gatttactgt tgtttccgca gttaaacgta ggatactttc
     9181 accacctaat gctgaaaaca ataaagataa catcacacaa ataataggga aaataagaat
     9241 caacttgcta atactcgtat tttttatttt taataaattt gataaaaaaa tttgtaccat
     9301 agcccctatc tcctcttttc aaataaaatt tgattattga ataactcttc aagattctca
     9361 gagccgtcat attctttttc cagaacaatc tttccttcat agataaatcc aataaaatca
     9421 gctagatgtt caacttctga cagtatatgg cttgaaatca taattgtcat tccttctgat
     9481 ttaaatgact ctataatttc ccttaattct tgaattccaa ttgggtccaa gccattagta
     9541 ggttcgtcta atataagtag tttaggtgaa tttattaaag agatagctat acctaaccgt
     9601 tgcttcattc caagagaaaa ttgttttact ggtctcttgt caatatctcc tagaccaact
     9661 ttatttaata atggaagtat agtgctttct gaaacaccaa gcattgttgt aactaccttc
     9721 atattatcgt aagcactcaa atttttataa agtggtggtt cttcaataat actcccgatt
     9781 tttcgcagat cccgacgtga ccattctcta ccttcaaaaa taatagaacc acttgtctta
     9841 ctaactaagc ctgtcaaaat tttcataata gttgattttc cagcaccatt tggaccgatt
     9901 aaagcataca cttttccctt aggaatattc atattgacat tattcaatat ggttctctta
     9961 ccataagatt tttttagatt ttgtattttc aacatattag ttactcccat tctatatatt
    10021 gctgagcgtt tagtgtatag taagcaaaac aatacacttt ctcttcaaac tctctatcaa
    10081 tcccgtttaa tcgattcatt gatagatgta aaaaacttcc tactaaattg aatttagtat
    10141 tatagatatc atttgtacca ccaaatcgat tatactcttt catataagac atgagatatc
    10201 tatccatttc ttggaaaaaa tcatatctat caagagctga ggtgactcca ttcaaactct
    10261 tcatatactc aataggtaaa tcaattggca aatttttgaa atctttctta tactttccag
    10321 tataattctc aaataagaaa gagcgccttg tttctttatc tttgaaaaag tgatttagat
    10381 aatatagaac caagtaagta gcacaaacta atctttcatc atctgaaaat tctattgtat
    10441 tattaagaaa taagatagat tctttacaaa aaatttcctc tgcataactt attaaatgag
    10501 gtcctccata tctatttact tctggtttat agctactcac ttctatgtca gagataatac
    10561 aactctcaat cagttgaggt aatagatctt gaactactga caaatacaaa gaaaagttat
    10621 tttcaatcga atcacaattt atccgaattc ttatatgatc attggtatca ttatatctca
    10681 tataaaacat gttactttgg ctaaacagtt ctgatggcag gtttagccaa aattttttcc
    10741 agttatttag taattcttct tgtcgctctt ttggaccata aaatttgaaa aatagccagt
    10801 cacaaaatgg taaatatatt ttcttaactt catttttaaa ttgaacatta tcgtttgtat
    10861 tgtttattcc attagattcc ttaagaattg gaactactat ctctgtattg tagtttccta
    10921 aattatcctt aaaaatagac tctccctgct caattcctct caaagaaaca aacctatatt
    10981 tattaatgtt tttaaataaa atctctaaat cactatctat agataaatct aacctcaatt
    11041 cattatctgc atatttcaaa ataatatctt taggtatctt ataagtcttt ctaaacttat
    11101 tgaatatatc ttttttacca gtaaatattt tttgatgtat aatctcttct ctaattactg
    11161 ataaattcca ctgagcagtg gcaatcgtaa tgtcttcaaa taaaatttca ggaatatata
    11221 ctctttcctg agccaaaata tcccaaggaa ataatgacca atgcgataaa ccgtactcaa
    11281 actcagataa atcaaccaac aatctcaaaa ccctgctttg gctatcggaa tttagcatat
    11341 tattcatggt aaatttcaac tcatttttcc catcgatagt tgtaaaatga aacttaccat
    11401 cactatatct tatataaata tcctccaatc gcagttcgtt ctctgaatcc catgatgtgg
    11461 taaaaaatga agtattataa gactcatcac tataattttg aattacattc gcaagtctta
    11521 tctgtttagg aacaaatgac aactctacat tcgtattatt ttgatggttt aaattcttaa
    11581 ttgtttctct tactgtttcg cttaatccat agaatcttcc aaagcttcta cctgcttgtc
    11641 cagaaccgat attagctcct aaatataact tcacatcatt atttattatt tttatattaa
    11701 aatttaattc aaacgaatct aaactattgc tttgatctgt ttgaaaatca tctaaatctt
    11761 ttgaataaaa ttcgatatgc cctccattta atagagcttc ctcatatttc ttttcaaaca
    11821 tttgcattat tggatcgctt aactctattg cttcaccctc tcctcctttg taatattcag
    11881 gaaagcctat gcctgcatct ttatttatta cttcaacaaa gggaattgag cagttttctc
    11941 catatttgcc aataaatttc aactgatact cttcaagtga atttttcctc ccccctcttc
    12001 tctttacatt tgtatttaat tttacaaaca tctctgcgag tcgttctata ctttcccgag
    12061 ccgtttcaga tagaatatta aaaccgcctt catactctgc taatgaatca acttttaagt
    12121 aatttccacc gttatcatat ttataaatac tttccatttt atcaaaaatc tgcaaaagta
    12181 agtctctacc ttccccaata tttaaatcgt tgtaatcttc aatcatcttc tttaaagtag
    12241 ttaagtcagt acatagtgtt ccttcttcta atttagatag tagataatct aaggaattga
    12301 tattacaaat tggtggtctt aaatctgaaa ttaaaaaatc atttgtaact aagtcgtgta
    12361 tatatgactc tagcatgtct gacactatat ctggataatt atttttaaat acatctatta
    12421 actcttcata ttttatatat cgagttttac atttttctac aagtaactta attggttttg
    12481 aaaaacttat gtttctatct tcctctgatt cattcactgt aaatggtagt acatatctgt
    12541 caccttgagt aaacgccgct gtatttattt ttaatgaaag tttttcaagg ttacttattt
    12601 catacgattt tactagagaa tatatccatg aataatctgg gactgctttt ttaataaaac
    12661 taaccttttg tacattagaa gtggttccct ttgtcaaatc aactgtatta atagcagtaa
    12721 agataccaaa tggagtagtt ctaaacgctg ctcttttaga ataactattt aatgagactt
    12781 ttacattttg ctttttcttt tcattacatt tatcaaaatc tattacacta tcataaagac
    12841 tgggactagc aactaaaagt tgttccataa aaactttatc atttattaaa tcttcatagt
    12901 ctttattata aaattcttgt ttttgcaatg gaatacgaat cataccagtt ggaaatacct
    12961 tatacatttt gttctccttt tcaaattaaa taaatattct ttgccacaat agctcctcgt
    13021 cactgtaagg atttaataag aataacacta tccctgatac cccttgcaat atccctattg
    13081 actccagttc aacttctatt tctccaaatt tttctctgtc agtataccca aatacttttg
    13141 tagttgaaaa cgatgtaatt atttgttggc gaagctcttc tgcaaagcga gttagcctct
    13201 cacttgaata atttttacca atcaagtcat atataaaagt tactcctgcc aaaccatggc
    13261 acattgtaag agaatagaca tttttgtctg aacttctcat ctgagcaatt aaactttcat
    13321 taatatcgtc aataaaattt aaatctatca attgacacat tttaaaaagg gcaactgcag
    13381 ttccaggcgt accgtaacac catgccattc tagtaggaag ataatttaaa tcaagatcca
    13441 aaatattact agtataaatt tttccaggcc atagtttgtc atcccttcta aataaaaaca
    13501 ttaaatttat agctttattc agtatatctc ctacttctac actcaaaatt ttttctgatt
    13561 ttaattttgc tagggttagc ataggaccag taattccatg tgcaattcct agatcaaatt
    13621 cagcttctct atcttcagaa caattagtta ccttatttaa aattgtctca atatatttca
    13681 aaagataatt tccaatttga tttaactcta cagaaaaaaa ttcttgttca aggagtaagt
    13741 aattagttat tccactaaat ccgttaacca tatcataatc atatggctca ataattcctt
    13801 tctcaatatt agaaaaactt actaccaatt tgtctttaat ttgttctttt agaagacaat
    13861 ttaaggatga taataatttc ggacaatact ttccagatat actcgcttct ttaatagcta
    13921 atgcaatacc tgcagtgcca gcatagagag acggagattc tataccatct ctagagatta
    13981 tgtctactaa tttctcaacg tatatgttgg agaatgttag atatctctca tcttttgtca
    14041 ctttatatag tgaactatac attaagatta atgatggcac accatgactc agagatttat
    14101 caaaaaaggt atttctatat ttagattcaa tattaattag tactttattc tcactttcag
    14161 ctactatctg ttcataattt ataaaactat ctgcaatgta atctactatc tgtttaattt
    14221 gaggtgtcat atgtggctcc aatttcttta tctaataagt ttttaaactt cattccttta
    14281 atatttaaat cagcgaaact tcctgtttca gctatacatc cattatctag atacaaaatt
    14341 ttattcacag attgagtaat gcttggctta tgcgtaataa aaataccaat tttattttgc
    14401 gataattcaa aaaatgtttt aaaaattttt gtttcagact caggatctaa cgcagaacta
    14461 ggctcatcta gcaaatagca atccgcttct ttgagatata ctcttgataa tgcaattttt
    14521 tgccactgtc caccagataa ctgcctccca tcctcaaacc aattccctaa ttgctgttcc
    14581 agatctatct gatttaattt ttcctgatta aagtaaaata tcgaatcaac tcccgtatac
    14641 ttcagtgcac ttattaaatc ctcatcacta tataactttg ataattcacc caatccaaca
    14701 ttttcacgca gtgtcaattc atactttaaa aaatcttgga acaatgcgga tattctcttg
    14761 tagtatgact ttttctgtat tgaacgaaga ttaataccat ttatatatat attgccttca
    14821 taattatcgt aaagaccgca ggctaatttg aaaatcgtac tttttccaga accattttca
    14881 ccaacaattg ctaacctctc tcctgcttta attgaaaaac ttatatcgtt tattacatta
    14941 tccttaccat tatatgaaaa agaaaccctt tcaaattcaa ctgactgaat tgtatcaacc
    15001 gtactttcga ttatagggtt atgtactaac tcatcatgcg taaaatcata caataactcc
    15061 atgtacaatg aaccattata gaaagaatag atattattta ctatattttg tgtacttgtt
    15121 tgcattgtag ataaagacct tataaaagta gttacatttc caactaataa tattcctaga
    15181 aatgcttctc taactgcaag gaacataata atagattgta tagcaatctc caatacacct
    15241 aatactatgc cgtatttcat tttagatcta tttatactat tttcctgatt aataaataat
    15301 tgattatttt tatcatattt ttttagaaaa taactttcta acgtacctaa cctcaactcc
    15361 ttgacagcaa aatcatgtgt taaaagatga ctaatatacc aatttgctct ctcatcgcta
    15421 ctccttttat atagtatctc aaattcattt ttactaattt tcaagtagat atatatagaa
    15481 acgataggaa ggataagtaa aagtggaaaa attgatatct tccaatttaa taaaataaca
    15541 aatgaggaaa ttaatgatac taacgaagat aatacagaaa taattgactt atatatttga
    15601 aaaggtttat aagatatttg attttgtatg cgagtgatat catcatagat ttctggtgtc
    15661 tcaaattcag ccaatgttaa ctttacagtt ttctgcataa ctaaatggtt catcttatag
    15721 tgaagaagta tctgtaattt ggtatcaata taactatcaa cttctcctat tataattgtc
    15781 aataatgtta aagcaatata tgagataaaa gcaatcatca atgtgtgaaa attttttata
    15841 tcagtcgtta taatgtttaa cattttttga actagtagca tactaaaaat gggtaaaatc
    15901 ccttgaaata agctaatagc aattgagaac accagtaggg agaaaccagc ctcttttacg
    15961 agatgaattg tttttattag attctttagc tgagctttaa tcatgtataa cttccttatc
    16021 tactaataaa ggagcaaact aaaatcagtc tactccccta aatttataaa tatatcaaat
    16081 tatttgaaat tataatgttg atgataatga taactttatt atttaacagt tgttgtaaag
    16141 caaactaatt tccaacaaga accaggggta cataggtaac ggctaccaac ataaggtgta
    16201 gcagtgtctt ttttatttgt tttcaaatcg agatcaaagt ctttaattgt gttattcatt
    16261 ttctagttcc tctcttacgt ttttgcatcc gatatattta catgattatt atgacacccc
    16321 aagttcagaa tttgttcaga aaaaaagtat tttagccaaa aatcacaaaa atttacgatt
    16381 ttttgcctga aatactccag tttcaatcaa atctattaaa ttttcttttt tatcgagatt
    16441 atggcgctag cacctcctct agctggatta ttcaattgaa gattcccacc gtgtttgata
    16501 gcaacgcctt taacaaatgc caaaccgatt ccataatgtt tgttacctct gctataatct
    16561 tccgtgtaaa ataatttatc tccctttttc agtgtactat cactgaaacg ctcaccatta
    16621 ttccatattt caaaatgaat ttgctctcct gactcagaca gtataacttc gattttttta
    16681 tctaatacgg gcataaatct tattgcatta actaaaaggt tagaaagagc tcttatcaga
    16741 ttttcctcat ctccataaaa agaagtgata ataagtctat tacaaataga aaattcaata
    16801 ttattgatat tcaataagtc atcgacttca aaatgtaact cacttaatag ctcctcaact
    16861 aaaattagtt tcactgatct atcctctgaa agcatgcgtg tataagatat taaagaattg
    16921 aaatagcctt caaaaacaga aatactattg ttcatagata caatataacc ttcctgattt
    16981 ttatttaaag tagtcaattc taataactca agatttcctt tcaaaaccgt taaaggtgtt
    17041 tttatatcat gcgaaagtgc tgcaatttga aaggatagat cttgcttttc caatatttct
    17101 cgctcaatca aacttttcaa attatcacct ttaatatgta aagttctaag tatatcatca
    17161 aactcgatta ttttagaata attttcattt tcagaaagga cttctatccc cattttattt
    17221 gctaacttct tgatttcctt gaaattcaaa gaaatttctt ttacaaaccg tgttaaagca
    17281 actacaatgc tgatactcgt tcctattccc agaatataaa atgtcaacat gttatatgaa
    17341 acatttctaa ggtaatggtt agaaaactcc ggtatctcat tatatcttat aacaatatta
    17401 taattgatat tagtatataa atcataatgt acagaattaa aagtcagatt atttttttct
    17461 tctgcaactt cgttaaataa agaaaattct ttagataaat attttccttc catagcttta
    17521 tctgtttttc tatcaaaaac aacataatct aatcccaatg tcttcatata attgttcaac
    17581 tgtttgattg actgtttatc tttaatataa aattcttctc ccacattatg agatgtcact
    17641 atatttaact ttgaaaaaga aagcgatatt atcgcaatca ttaaaacagt gatacaaact
    17701 ccaaagacaa tttcaacgac ggcgcgccaa acacgatttt ttattgaata ttttttaaac
    17761 atcccattta taaccaatcc cgcgaatagt ttttattgga ttaattccaa aacttgaaaa
    17821 tttcattcta atctgataga tatattctga aatagaatga aacaatgctg aagcttcatc
    17881 gctatatact tgttcatata tctcttcttt tgtgaaaact ttatacggat gacgtgacag
    17941 taattctaaa atttcgtact ctctataagt caggaataac ggctgtttat caatatataa
    18001 catacgttcc tctagataga tttctatagg tggaaaactt cgcttcactc tctcctcagc
    18061 ctcattcttt atctttgctc tctcttctct cttcaaatga gagttaactt tagctacgaa
    18121 ttgttttaag ctaaatggtt tcacaataaa atcgtctccc cctatattta aagcttggac
    18181 aatttcatta tcgccatcta aagcactaac aaaaataatt ggagaatgaa cttcttcccg
    18241 aattttataa caaaactcag ttccacttat attaggcatc atgatatcca ataagatcaa
    18301 atcatatcct ttaaaatcat caaaaactat tggtaattct atctcttgac aggttataac
    18361 atggtaattt tcaatctcca aagcagtctt cataagcttc agaatttctt tatcatcatc
    18421 tatggctaaa atcttataca ttattacccc ttttaaataa tgaaatactt acaaataaac
    18481 tattctcaat gtaagcggca ggaatcattt ctttaatata gttatttacg aaacatcaac
    18541 tagattttaa tatctgatat aaaaattgct accacccaaa ttatatcata attactccca
    18601 ttgtatttca tttcgagaag tatcgataat tttgctatca ctcaagatct ctccaaactt
    18661 ttccaacctt cttactagat attcatactc atctatggat atattaagtt cattttgaga
    18721 agtttcaatc tctttctcaa cttcttctat ttttatagct gcagtcaagt tcatcttggc
    18781 atagtcatat ctggccaaac ggcggttctc tatatcgttg ttgttcagat taagcaagac
    18841 ctccgcaacc ttattgagat gagcaatatg gtcctgcaac tctgtaatgg tcaaatctaa
    18901 ttgagccata tctttaacaa tgtcatcttt aatatcttga taaggcttat tctccgtatc
    18961 taactcaatg aggagactta tttcttcaat ctttttctta agtgtatcaa tggtttgtcg
    19021 tcttcttttt ggaatacttt tgctatcatt ggttaactgg taaatgagct catgccctcg
    19081 catatagcga ttaagttcag acgcctcctt gttgtaaatg aagaattgtg cggtctcacg
    19141 aatatagact ttatattttt tatgattttc ttctttccta atatccaatt gatagttagg
    19201 aatgaaaata agaccactct gctttacacc aaaagacacc ttgatataaa tgtcctcagc
    19261 aattaacctc tcaatttgat gttccacaag ttcaacttca aactcatgga tggtatctcg
    19321 ttgccccttg tatttcttga agacttcctt actctcttca gtggatacct tctctttatc
    19381 tcgttcttct tgaaaagcat gtattgtttc tgtagacttt ctaatcgatc tgaaacaccg
    19441 acttccttat tttttaaagt aatcttgaaa aaattgacat catataattt cttatcgctt
    19501 atttttttat gacctaaact tatcttttga gtatcttctt ctaggataaa agttacattt
    19561 tttgttttaa gtcaatggtt agattcactt cttttgcttt taatagtagc tcctctaatg
    19621 aattggcacg gttcaacaaa aattctaatc gactttcaat ttctatcttg gcaaaatgtg
    19681 tacgaaaaaa ttcttcatca tataaatctc gtttactgag ttgacggcct cgaattggtt
    19741 ttttcattac tcgatccgtc atcatgaatc tgctatgctt ctgactaaaa tcaatatgaa
    19801 catgtaatta ctctgctttt tctaaaaaat catcaaagaa ctttgactgc tgcatcaaaa
    19861 aataaagacg ttgctttagt tcaaacttat ggctagtcgc tttatatttt tgatagtcac
    19921 ggtaagagaa atgcttttca ataattttcg ccccagctat tttagaaata cggtctgaga
    19981 tcatacgaag atttcgttcc aaggcataat tccatatcaa ttttttatct gaattacggt
    20041 caatggcgct gattggatgt gattatgggt atgattttta tctgtttggt cgctcgagta
    20101 atctcaaaga agagagttct cctagtcccc tcaaatccca gtcgtctgcc tgcgagtgaa
    20161 aatgcttgac aagggaaaaa ccaccgcaga tgatatccac ttgccctcta agttgtctaa
    20221 agtcttggtc tgtgacttgt ctaatgtcat gaaattctat ttctccttcg gtctcataga
    20281 tggctttgta agattgcctc gcaaacttat caatctcaca aaagccaata cactcatggc
    20341 actgattaat taaacccaat cgaaagcctc caattcctgc aaacaaatct aaaaatttca
    20401 tatctctcat tcctttctga caaaataaaa ggaccttact gcttatgtaa cgtccttact
    20461 caactataat cttccatttc tggtgcagtg ataacttcaa taatcaacca aattgtcctt
    20521 agtccccaaa cacctaataa tagccaccaa aacatcttac tcacctcact tcgcttcttg
    20581 tcaccttagt tgcttggtcc attcggataa gacaccatta aagacatatt ccgcaatagc
    20641 ttcagctgtt cttgcgaacc gtatgtgttc cagcgcataa gcatagcgtt cttcaaaata
    20701 gctcatgact aagtcactag cagcttgtga taaaccacct tcacgtaatt gggaatgaac
    20761 caaactccaa atataatctt tgtcatattt ggtgatctga tcaacttgac gggtaaagtg
    20821 accctcagtc tttttcacac tagtgcactc ctttctttcc tcctcgtcct caatgactaa
    20881 attactctct ttagtttcac taccttcagt ttcactcttt tcagtctcac taggggctga
    20941 atttaacacg gggctggtct gtttttgaga ctggccccgt ctgaacttaa gactggggtg
    21001 gaatcatgtt ccaactttcc taaataaatc ttattagcca aacgcccttt ttcactggga
    21061 gactgttgga cttcatcgat caaaccatag tctcgtaggt tttcttaatc gctaacaatt
    21121 tcgacttgga acagccaagg agtactatca ttttgagttg gaataaatga gatagatggc
    21181 aatcaccatt tgtcgtgatg actgttcatt catttgcatg attttcctcc tgaaaataaa
    21241 aaaatgagaa cacttattaa aatgttctcg ttcacataaa aaaattatta ctagacacat
    21301 atagatagaa taaccactct actcagctta atttttatag aaaataaaaa tcctgccaaa
    21361 gattttttgg gcaggatttt tggcaagaaa ccaaatcaat ttatcagttt cttcaaatcg
    21421 ctataaactc taaaagactg ataaatcggg atttcgctct caaattgcta tctgcttctt
    21481 atttaagagt gattgttgct ccagcttctt caagtttagc tttgatttct tcagcttctg
    21541 cagcagcaac gccttcttta acgttagcag gtgctccatc aacaagacct ttagcttctt
    21601 taagaccaag acctgtgatt tcacgaacag ctttgataac gccaactttt ttgtcgccag
    21661 cagatgtcaa ttcaacgtcg aatgaatctt tagcagcttc ttcagcacca ccagcagctg
    21721 cagcagctac aggagcagct gcagttacac caaattcttc ttcgatagct tttacaagat
    21781 cgttaagctc aaggattgaa gcttctttaa tttcagcaat aatgttttca atgttcaatg
    21841 ccattgtgat ttcctccaaa taattaattt aaaatgttaa gcgtagcctt aagctactct
    21901 gagacgtctt aagcagcgcc ttctttgttt tctgcaacag ctttgacagc gtatgcaacg
    21961 ttgcggactg gagcttgaag tacagaaaga agcatagaaa gcattccttc gcggtttggc
    22021 aatgttgcaa gtgcttggat ttcttctttt gaagaaacag cgccttcgat tgcaccacct
    22081 ttgatttcaa gtgcgtcagc agttttagta aagtcgttga taactttagc tggtgcgata
    22141 acatcttcgt tagaaaatgc tactgcagat ggtcctacga atacatcttt caactcacca
    22201 agacctgctt tttcagctgc acgagtcaaa attgagtttt tgataacttt gaactcaacg
    22261 ccactttcac gaagtgaacg acgaagaaca gtatcttgat caactgtaag accacgtgaa
    22321 tcaacaacaa cgatacttgc tgctgctttc attttctcag caataagttc gacttgttca
    22381 gcttttttag caataattgc ttcactcatt agttttacct ccgtttttat ttttgggcta
    22441 ggtacaaaaa aatcgcacct aaacctagac acgaaagtac aaatacgtta ttttctttaa
    22501 tcacgttttg tgcctcggca ggaatattat gagcatgctc ccctgctgtc ttaggtcagt
    22561 tttttatcaa aacctatatc attatattct tttataatac tattgtcaat aaaaattatt
    22621 aaaaaaatga tttttttaca tttatttttt ttagtattag ctaaactcaa aatggtgcta
    22681 gtcctatttt ctatacaaaa taataccttg ctttctacta ggacttgatt taaaatagag
    22741 ggcatgagta taactaaaga atttgataca attaccgcca tttcaacccc tcttggtgaa
    22801 ggagctattg gcattgttcg tctatccggg acagatgcgc ttgccattgc acaatctgtt
    22861 tttaagggaa agaacttaga gcaagtcgcc tcacacacca ttaactatgg ccatatcatt
    22921 gatcctaaga caggaactat tatcgatgaa gttatggtgt cagtcatgct agcccccaaa
    22981 acctttaccc gtgaaaatgt ggttgaaatc aatacgcacg gtggtattgc tgtgacaaat
    23041 ggaatcttgc aactattgat tcgccaaggc gctagaatgg cagagcctgg cgaattcacc
    23101 aaacgtgcct tcttaaatgg tcgtgttgat ttgactcaag ctgaggctgt catggacatt
    23161 attcgtgcca aaacagacaa ggctatgacg attgcagtca agcaactgga tggctccctt
    23221 tcccagctta tcaatgacac ccgtcaggaa attctcaaca ccttagctca agtcgaagtc
    23281 aatattgact accctgaata cgacgatgtg gaagaaatga ccactgctct gctacgtgag
    23341 aaaacacaag aattccaaag ccttttggaa aatctccttc gaacagctaa acgcggtaaa
    23401 attctgcgtg agggcttatc aacagctatt attggtcgtc caaacgtcgg taagtcaagc
    23461 ttacttaata atttgttgcg agaagacaag gctattgtga ctgatattgc aggaaccacc
    23521 cgagatgtca ttgaagaata cgttaatatt aagggagttc ctctaaaact tgtcgatacg
    23581 gccggtattc gtgagacaga tgatctggtc gaacaaatcg gagttgaacg gtctaaaaaa
    23641 gctcttcaag aagctgacct tgttcttctt gtgctaaatg cttctgaaaa actgaccgac
    23701 caagaccggg ctttgttaaa tctcagtcag gacagtaacc gtattatatt gttgaataaa
    23761 acggatttgg aacaaaagat tgaattagag caattaccag atgactatat tcccatttcc
    23821 gttttaacca accaaaacat taatctgatc gaagatcgta tcaaccagct cttctttgat
    23881 aatgctggac tagtagagca agatgccact tacctgtcaa atgcccgcca catttctttg
    23941 attgaaaagg cagtccagag tttagaagct gtcaatgacg gcttggcgct tggcatgcca
    24001 gttgatttac tacaggttga tttaaccaga acttgggaaa ttctcggaga aatcacaggg
    24061 gatgctgctc ctgatgaact cattacccaa ctctttagcc aattttgtct tggtaaataa
    24121 gaccattctc taatcatcac aaaagagctg gaacagtgtt ccagctcttt ttgctgtcat
    24181 aagcatctta tttaattaat tcgtagattg cttcagcata aatagctgct
//
