LOCUS       NZ_LS483389            20873 bp    DNA     circular CON 13-FEB-2024
DEFINITION  Streptococcus pyogenes strain NCTC10879 chromosome 1, complete
            sequence.
ACCESSION   NZ_LS483389
VERSION     NZ_LS483389.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Doyle,S.
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 01:12:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,924
            CDSs (total)                      :: 1,835
            Genes (coding)                    :: 1,780
            CDSs (with protein)               :: 1,780
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 55
            CDSs (without protein)            :: 55
            Pseudo Genes (ambiguous residues) :: 0 of 55
            Pseudo Genes (frameshifted)       :: 36 of 55
            Pseudo Genes (incomplete)         :: 21 of 55
            Pseudo Genes (internal stop)      :: 26 of 55
            Pseudo Genes (multiple problems)  :: 22 of 55
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:51:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 612195
            Orig. end                         :: 633068
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LS483389.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20873
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20873
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20873
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10873](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10873
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(765..785)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.95"
                     /tool="antismash"
     misc_feature    1659..1672
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.93"
                     /tool="antismash"
     gene            2046..2276
                     /locus_tag="DQM81_RS03175"
                     /old_locus_tag="NCTC10879_00625"
     CDS             2046..2276
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003105222.1"
                     /locus_tag="DQM81_RS03175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00625"
                     /product="YkuJ family protein"
                     /protein_id="WP_002983885.1"
                     /transl_table=11
                     /translation="MESHLVRIINRLELMVTDGGNLKRNFERDGVVVAEVAFSNDPENG
                     PVFTLRDVEARESYSFDSIDLIAMEIYDLLY"
     gene            2403..3089
                     /locus_tag="DQM81_RS03180"
                     /old_locus_tag="NCTC10879_00626"
     CDS             2403..3089
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011018000.1"
                     /locus_tag="DQM81_RS03180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00626"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_002983887.1"
                     /transl_table=11
                     /translation="MDLSFLPKYWAYFNYGVLVTIMISVSVVFFGTLIGVLVTLIKRSH
                     VKPLTWVVNLYVWIFRGTPMVVQIMIAFAWMHFNNMPTIGFGVLDLDFSRLLPGIIIIS
                     LNSGAYISEIVRAGIEAVPKGQLEAAYSLGIRPQNAMRYVILPQAFKNILPALGNEFIT
                     IIKDSALLQTIGVMELWNGAQSVVTATYSPISPLLVAAFYYLMVTTVMAQLLAVLERHM
                     AQGGNH"
     gene            3089..3823
                     /locus_tag="DQM81_RS03185"
                     /old_locus_tag="NCTC10879_00627"
     CDS             3089..3823
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407690.1"
                     /locus_tag="DQM81_RS03185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00627"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_063631453.1"
                     /transl_table=11
                     /translation="MTEAIISIKDLHKYYGHNEVLKGIDLDIMPGEVVVIIGPSGSGKS
                     TLLRTMNLLEVPTKGQIRFEGIDITDKKNDIFSMREKMGMVFQQFNLFPNMTILENITL
                     SPIKTKGMANAEADKTALSLLDKVGLSEKAKAYPASLSGGQQQRIAIARGLAMDPDVLL
                     FDEPTSALDPEMVGEVLAVMQDLAKSGMTMVIVTHEMGFAKEVADRVIFMDGGVIVEEG
                     SPNQLFDLTKEERTKDFLSRVL"
     gene            3972..5381
                     /locus_tag="DQM81_RS03190"
                     /old_locus_tag="NCTC10879_00628"
     CDS             3972..5381
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989109.1"
                     /locus_tag="DQM81_RS03190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00628"
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_063631454.1"
                     /transl_table=11
                     /translation="MVSVMWFRRDLRIDDQKALAHVIASQSPTLCVFQFNKEQLNLLHS
                     RNQSSFITSVLAFRKLLKCEGIDLYLMYGDLMTCFEQLLTQLKDWTDVYFNYDESGYGR
                     LRDQKAAQFFKKNGIAVHTYQDHYLHGSQEIINQSGQPYKVFTPYYRIWQNYPKETPIK
                     VELSQGRWLNLETPDDVLRTVESFKDEKYQDVATFDEASKQLNRFIQDQLAAYHANRDF
                     PAQLGTSRLSPFLRIGAIGIRTVYHAVRQAPNSLGQATFLKELAWRDFYNMVYVAYPDQ
                     KTQPIQKAFSQIEWVNNPDWFQLWKEGKTGYPIVDAAMLQLQKTGWMHNRLRMIVASFL
                     TKDLLCDWRLGEQYFQQQLIDYDAASNIGGWQWTASTGTDAVPYFRIFNPVTQGKRFDP
                     KGEFIKAYLPQLEHVPEKYLHEPWKMPKNLQESVSCIIGTDYAQPIVDHAKQREQAIAK
                     YEWAKEKAKIE"
     misc_feature    complement(5497..5508)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.16"
                     /tool="antismash"
     misc_feature    5526..5541
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.0"
                     /tool="antismash"
     gene            5559..7253
                     /locus_tag="DQM81_RS03195"
                     /old_locus_tag="NCTC10879_00629"
     CDS             5559..7253
                     /EC_number="5.4.2.-"
                     /GO_function="GO:0016868 - intramolecular
                     phosphotransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635581.1"
                     /locus_tag="DQM81_RS03195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00629"
                     /product="phospho-sugar mutase"
                     /protein_id="WP_002989112.1"
                     /transl_table=11
                     /translation="MTYNEVYQEWLHNNDLSDDIKADLAAIKDNEAEIQDRFYKTLEFG
                     TAGLRGKLGAGTNRMNTYMVGKAAQALANTIIDHGPEAVKKGIAVSYDVRYQSRTFAEL
                     TCSIMAANGIKAYLYKGIRPTPMCSYAIRALGCISGVMITASHNPQAYNGYKAYWQEGS
                     QILDDIADQIAQHMAALTQYQEIKQMPFEKALDSGLVTYIDESIEEAYKKEVLGLTIND
                     TDIDKSVRVVYTPLNGVGNLPVREVLRRRGFENVYVVPEQEMPDPDFTTVGYPNPEVPK
                     TFAYSEKLGKAVDADILIATDPDCDRVALEVKNAVGDYVFLNGNKIGALLSYYIFSQRF
                     DLGNLPANPVLVKSIVTGDLSRAIASHYGIETVETLTGFKNICGKANEYDVTKQKNYLF
                     GYEESIGFCYGTFVRDKDAVSASMMIVEMAAYYKKKGQNLLDVLQTIYATFGYYNERQI
                     ALELEGIEGQKRIARIMEDFRQTPIASVAEMALDKTIDFIDGYQDFPKQNCLKFYLDDG
                     SWYALRPSGTEPKIKFYLYTIGQTQENSATKLDAIEAACRTKINQVN"
     gene            7461..8315
                     /locus_tag="DQM81_RS03200"
                     /old_locus_tag="NCTC10879_00630"
     CDS             7461..8315
                     /GO_function="GO:0004488 - methylenetetrahydrofolate
                     dehydrogenase (NADP+) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922486.1"
                     /locus_tag="DQM81_RS03200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00630"
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/methenyltetrahydrofolate cyclohydrolase"
                     /protein_id="WP_010922486.1"
                     /transl_table=11
                     /translation="MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPA
                     SQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHI
                     NDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVI
                     IGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKD
                     GAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRS
                     THK"
     gene            8468..9808
                     /gene="xseA"
                     /locus_tag="DQM81_RS03205"
                     /old_locus_tag="NCTC10879_00631"
     CDS             8468..9808
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="xseA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989115.1"
                     /locus_tag="DQM81_RS03205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00631"
                     /product="exodeoxyribonuclease VII large subunit"
                     /protein_id="WP_014407687.1"
                     /transl_table=11
                     /translation="MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYF
                     SLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDGIG
                     ALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFPGV
                     EILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIF
                     ESQLPVISSVGHETDTTLADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQA
                     CLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKENKVQ
                     LDHSLANSQLQTKIERYQDRVATAKRLLMANMASQYDSQLARFEKAQDALLSLDASRII
                     ARGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI"
     gene            9786..10001
                     /locus_tag="DQM81_RS03210"
                     /old_locus_tag="NCTC10879_00632"
     CDS             9786..10001
                     /EC_number="3.1.11.6"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983901.1"
                     /locus_tag="DQM81_RS03210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00632"
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_002983901.1"
                     /transl_table=11
                     /translation="MSKTKTFEENLQDLETIVNKLENGDVPLEEAISEFQKGMLLSKEL
                     QKTLQAAEKTLVKVMQADGTEVDMDD"
     gene            10001..10873
                     /locus_tag="DQM81_RS03215"
                     /old_locus_tag="NCTC10879_00633"
     CDS             10001..10873
                     /EC_number="2.5.1.10"
                     /GO_function="GO:0004337 - geranyltranstransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888744.1"
                     /locus_tag="DQM81_RS03215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00633"
                     /product="farnesyl diphosphate synthase"
                     /protein_id="WP_011284950.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.9e-51, bitscore:
                     170.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKLARIDEAIRRYYKTTSNGVSEELIDAILYSVDSGGKRIRPLI
                     LLEMIEGFGVSLQNAHFDLAAALEMIHTGSLIHDDLPAMDNDDYRRGRLTNHKQFGEAT
                     AILAGDSLFLDPFGLIAQAELNSEVKVALIQELSLASGTFGMVGGQMLDMKGENQALSL
                     PQLSLIHLNKTGKLLTFPFKAAALVTEQAITVRQQLEQAGMLIGHAFQIRDDILDVTAS
                     FEDLGKTPKKDLFAEKATYPSLLGLEASYQLLTESLDQALTIFQTLESDVGFKPQIITK
                     LIEGLRLNA"
     gene            10866..11693
                     /locus_tag="DQM81_RS03220"
                     /old_locus_tag="NCTC10879_00634"
     CDS             10866..11693
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015017216.1"
                     /locus_tag="DQM81_RS03220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00634"
                     /product="TlyA family RNA methyltransferase"
                     /protein_id="WP_011054705.1"
                     /transl_table=11
                     /translation="MPKERVDVLAYKQGLFETREQAKRGVMAGLVVSVINGQRYDKPGD
                     KIDDGTELKLKGEKLKYVSRGGLKLEKGLHVFGVSVANQIGIDIGASTGGFTDVMLQDG
                     AKLVYAVDVGTNQLVWKLRQDPRVRSMEQYNFRYAQPEDFSEGQPVFASIDVSFISLSL
                     ILPALHNVLSDQGQVIALIKPQFEAGREQIGKKGIVKDKQIHEKVIQKVMDFASGYGFT
                     VKGLDFSPIQGGHGNIEFLAHLVKSQTPETLAPHLIQEVVAKAHKEFEKHEKK"
     gene            11680..12150
                     /locus_tag="DQM81_RS03225"
                     /old_locus_tag="NCTC10879_00635"
     CDS             11680..12150
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002983907.1"
                     /locus_tag="DQM81_RS03225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00635"
                     /product="arginine repressor"
                     /protein_id="WP_002983907.1"
                     /transl_table=11
                     /translation="MKKSERLELIKKMVLTHPIETQHDLLRLLAEHGLELTQATISRDM
                     NEIGIVKIPSGSGRYIYGLSQDSGKKIVQGPRSIKSTILAVSDKTKGLEQHLYLKVVPG
                     NSKLIKRYLLADFSKAIFSLIADDDSLLLIAKSPSEADMIRQEILLWMQGIT"
     gene            12172..13833
                     /gene="recN"
                     /locus_tag="DQM81_RS03230"
                     /old_locus_tag="NCTC10879_00636"
     CDS             12172..13833
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051804.1"
                     /locus_tag="DQM81_RS03230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00636"
                     /product="DNA repair protein RecN"
                     /protein_id="WP_063631455.1"
                     /transl_table=11
                     /translation="MLLEISIKNFAIIDEISLNFENGMTVLTGETGAGKSIIIDAMNMM
                     LGARASTEVIRRGANKAEIEGFFSVDATPELVACLESSGIAMEEELIIRRDIFANGRSV
                     SRINGQMVNLAALKQVGQFLVDIHGQHDQEELMRPQLHQQILDAFGDKAFEQLKENYQL
                     IFDRYKSLRRQVIDKQKNKKEHKDRIDMLAFQIAEIEAAALSRGEDDRLNQERDRLMNH
                     KQIADTLTNAYVMLDNDDFSSLSNIRSSMNDLLSIEQFDSEYKGMSTSISEAYYILEEV
                     SKQLSDTIDQLDFDGGRLQEIEFRLDTLNSLTRKYGGNVNDVLDYYDNIIKEYQLLTGD
                     DLSSGDLEAELKSLEKQLVAAASELSVSRHQLAEQLEAEIKAELKELYMEKADFKVHFT
                     TSKFNRDGNESLEFYISTNPGEGFKPLVKVASGGELSRLMLAIKAAISRKEDKTSIVFD
                     EVDTGVSGRVAQAIAQKIYKIGRHGQVLAISHLPQVIAIADYQYFISKESKEESTVSKV
                     RLLTPEERVEEIASMIAGTDMTQAALTQARELLAKH"
     gene            14005..14970
                     /locus_tag="DQM81_RS03235"
                     /old_locus_tag="NCTC10879_00637"
     CDS             14005..14970
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285633.1"
                     /locus_tag="DQM81_RS03235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00637"
                     /product="LPXTG cell wall anchor domain-containing protein"
                     /protein_id="WP_111688263.1"
                     /transl_table=11
                     /translation="MTSKKACLSSIIVLASLTCGNDTVSANHLSATGDKFDDCSTLVEK
                     DVAPKDELEMLAWSSSQTTDDADRDYEDFLDDDSFNDDSFISQNETDKMFENLTDDRLL
                     NELDESDEEDEEDEEDEEDTIEPEQNVIMPSDDELFDLTDAVETRLTVSSAPHLEAELP
                     KPHLRSLSDTALRSGEIRGHLDNKLDALSVTATKLALTMAQKFDLTTHVYSIGESFSEV
                     LAAHYEDRKAESAFSKKKRFHLPIATPDVVIEELRRLVSSIGSSKEDVSVPYNRKLGMA
                     VAKRKIALPQTGEGFSYYPALLGLMILGLTPIMIPKKINN"
     gene            15198..16037
                     /locus_tag="DQM81_RS03240"
                     /old_locus_tag="NCTC10879_00638"
     CDS             15198..16037
                     /GO_function="GO:0005504 - fatty acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002264715.1"
                     /locus_tag="DQM81_RS03240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00638"
                     /product="DegV family protein"
                     /protein_id="WP_002989125.1"
                     /transl_table=11
                     /translation="MGTIKIVTDSSITIEPELIKALDITVVPLSVMIDSKLYSDNDLKE
                     EGHFLSLMKASKSLPKTSQPPVGLFAETYENLVKKGVTDIVAIHLSPALSGTIEASRQG
                     AEIAEAPVTVLDSGFTDQAMKFQVVEAAKMAKAGASLNEILAAVQAIKSKTELYIGVST
                     LENLVKGGRIGRVTGVLSSLLNVKVVMALKNDELKTLVKGRGNKTFTKWLDSYLAKNSH
                     RPIAEIAISYAGEASLALTLKERIAAYYNHSISVLETGSIIQTHTGEGAFAVMVRYE"
     gene            16030..16872
                     /locus_tag="DQM81_RS03245"
                     /old_locus_tag="NCTC10879_00639"
     CDS             16030..16872
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014635578.1"
                     /locus_tag="DQM81_RS03245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00639"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_063631457.1"
                     /transl_table=11
                     /translation="MNNRHLFSGIFFFVISLCLAFLLLNIIIPKSNSRLKKSDFLKKEQ
                     VAIQYVAIGDSLTEGVGDLTHQGGFVPLLTNDLSEYFKANVNHQNYGVSGDTSQQILDR
                     MIKQKQIQLSLKKADIMTLTVGGNDIMAVIRKNLADLQVSSFRKPARQYQKRLRQIIEL
                     ARKDNKDLPIFILGIYNPFYLNFPELTDMQKVIDDWNTKTKEVVGEYDRVYFVPINDLL
                     YKGINGQEGIVHSSGDQTTIVNDALFTGDHFHPNNTGYQIMSNAVMEKIKKHEKKIKP"
     gene            16850..17437
                     /locus_tag="DQM81_RS03250"
                     /old_locus_tag="NCTC10879_00640"
     CDS             16850..17437
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922482.1"
                     /locus_tag="DQM81_RS03250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00640"
                     /product="YpmS family protein"
                     /protein_id="WP_002989129.1"
                     /transl_table=11
                     /translation="MKKKSNLNWWKWSFLCLLAFNTAFLMVIASRLIQVREPESELIAK
                     KPVKNIKIGTFVTTREQLNETVASYLKDYQTKKMSYKFYATSSSILFEGTYQLLGYEVP
                     LYIYFQPHRLENGAVQLQVISFSVGTLPLPEKDVLQYLKSSYKLPSFVKVMPNQSAIVV
                     NLQDIQNDAKVYLKAKKIDLFNDEISFNIYKK"
     gene            17536..17811
                     /locus_tag="DQM81_RS03255"
                     /old_locus_tag="NCTC10879_00641"
     CDS             17536..17811
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1132: DNA-binding
                     protein HU 1"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002950996.1"
                     /locus_tag="DQM81_RS03255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00641"
                     /product="HU family DNA-binding protein"
                     /protein_id="WP_002983920.1"
                     /transl_table=11
                     /translation="MANKQDLIAKVAEATELTKKDSAAAVDAVFSTIEAFLAEGEKVQL
                     IGFGNFEVRERAARKGRNPQTGAEIEIAASKVPAFKAGKALKDAVK"
     gene            complement(17900..19042)
                     /locus_tag="DQM81_RS03260"
                     /old_locus_tag="NCTC10879_00642"
     CDS             complement(17900..19042)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003051793.1"
                     /locus_tag="DQM81_RS03260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00642"
                     /product="site-specific integrase"
                     /protein_id="WP_003051793.1"
                     /transl_table=11
                     /translation="MWIEETDNGKFKFRENYKDPYTGTWKPVSVTMEKDNSRAYKAARK
                     ILEQKITEKIAQLKASELLFTELLDEWWAFYKKELKRSSVASLRGNIEEIRETFGIGVK
                     VVNIDPKYVQNYLDNLDCSRNKKERNKSMLNLAFDYAVGLDIIQDNPARRAKLPRVKKT
                     LEDWKKAEEKYLEEDEIKPLLKELYRRPSTYRLGLLAEFISLNGCRIGEAVSIEPCNYE
                     SKSRILQLHGTFDHTEGYRNGEKTAPKTLASYRETIMTSRELEILQELEFMNELEKNTN
                     HRYRDMGYLFTTKNGVPIQTNSFNLALKKANERLEDPITKKLTSHIFRHTLISRLAENN
                     VPLKSIMERVGHADAKTTAQIYTHVTKKMKSSVADIMENY"
     gene            complement(19166..19684)
                     /locus_tag="DQM81_RS03265"
                     /old_locus_tag="NCTC10879_00643"
     CDS             complement(19166..19684)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922481.1"
                     /locus_tag="DQM81_RS03265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00643"
                     /product="HIRAN domain-containing protein"
                     /protein_id="WP_011528799.1"
                     /transl_table=11
                     /translation="MAKVIFQDNFLLMGTNYHEKEANKVMAEIGKKSPYWDKDKDFISD
                     YIKSNFKDIYKYYRVSTKDVEVVREPLNRHDPNAIKVMVNKTFVGYFPADLAKRLTPYV
                     KKSSHYQMEATLTGRGGQYKTLKNDLKTVVTKKKDITYKLRLTILKVDRVSKSKNAGLL
                     ESIASWFLN"
     gene            complement(19696..20451)
                     /locus_tag="DQM81_RS03270"
                     /old_locus_tag="NCTC10879_00644"
     CDS             complement(19696..20451)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922480.1"
                     /locus_tag="DQM81_RS03270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00644"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_010922480.1"
                     /transl_table=11
                     /translation="MEQLGDRIRKLREGRNMTQTELSEILGMKTYTTVSKWEKNENFPK
                     GKDLKKLAEIFNVTSDYLLGLTDSKLGKITIQNEQPEIVSIYNQLEQPRQEKVLNFANE
                     QLEEQNKTVSIFDKKSEETEDYITDYVEGLVAAGLGAYQEDNLHMKVKLRSDDVPDEYD
                     TIAKVAGDSMEPLIQDNDLLFIKVSSQVDMNDIGIFQVNGKNFVKKLKRDYDGAWYLQS
                     LNKSYEEIYLSKDDDIRTIGEVVDIYREY"
     misc_feature    20547..20562
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.59"
                     /tool="antismash"
     misc_feature    20553..20566
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     misc_feature    20554..20567
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.7"
                     /tool="antismash"
     gene            20653..20865
                     /locus_tag="DQM81_RS03275"
                     /old_locus_tag="NCTC10879_00645"
     CDS             20653..20865
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922479.1"
                     /locus_tag="DQM81_RS03275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC10879_00645"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_010922479.1"
                     /transl_table=11
                     /translation="MVTIAELRAKHNKMSQRELAKELGVTQTSISNWEKDQTKISGEYL
                     ISLALFFDVSTDDILGINKQATQKF"
ORIGIN
        1 agaacttgta agaacatgtg catgacgtca ggatgggctt tttccacctc atctaagaga
       61 ataagggaat aaggattgcg acgaacttgt tcggttagct gtccagcttc ttcatagccg
      121 acataacctg gaggagcccc gactaatttg gcgacagcgt gtttttccat gtattcggac
      181 atgtcaaagc gaatcatatt gtttgtcgaa ccaaagagtt caatggctag ttgtttagac
      241 aattcagttt taccaacccc agtcggtcca acgaataaga aagaaccaat agggcgattt
      301 ggagttccta atcccacacg gttacgacga atagccttag cgattttatc aacagcatcg
      361 tcttgcccga tcacgtgtgc tttcagatca ttggctaagt ttacgagttg agactgttcc
      421 ttttctttta agtccccaac tggaatatta gttttttgct ctacaatagc ttcaatggtt
      481 ttttcagtaa tgatgggaat atcttgctca tcgacttttt gagcctgcat ttctttgtat
      541 tttgtaattt gatcgcggaa ataagctgcg cgttcatagt cttcgtctcg agtagcttgc
      601 gccttgagat tctcagcttc aataagacgt ttgtcaattt ctttaggatc aacaaagttg
      661 agggttagat tcattttgga accagcttcg tccagaaggt caatagcctt atcaggaaga
      721 aaacggtctt gaatatagcg gttagataaa tgagcggcag cttcaatagc ggctgggcta
      781 tatttgacat gatgatagtc ttcgtatttc ggttggatac cttttaaaat cgtgatggtt
      841 tcctcaacag aaggttcatc aactttaacg ggttgcatac gtcgttctaa ggcagcgtct
      901 ttttcaataa tacggtattc atttaaggtg gtagcgccga ccaactgcaa ttcaccgcgg
      961 gccaaggctg gttttaaaat attaccagca tccatattgc cgtctcctgc agaaccagca
     1021 ccgacaatct catgaatttc atcaataaag agaatcacat ccttgcgatt gcgaatttct
     1081 tccattaatt tttgcatgcg ctcttcaaac tgaccacgga tacctgttcc ctgaacgagg
     1141 ctaaccacat caagacgaat cacttgcttg ccttggagtt tttgaggaac agtaccatca
     1201 ataatttttt gagccaaacc ttctacaaca gcagttttac caactccagg ctcaccaatt
     1261 agcacaggat tatttttagt acggcggttg aggatctcga taacgcgtgt aatctcttcg
     1321 tcacgaccaa taacaggatc aatattacca tttcttgcaa tatctgtgac attaatccca
     1381 aactcttcta acaagccctt tgcttgctga tttggtgttt gtggctgagc aggtcgttgt
     1441 ccgttgtagt taccaccata gcgtcctccg ccatttccat tttgccctgc ctgagtaggt
     1501 ggggtatttg gaagattacc aaaagctcta aaattattca aatcaccaaa aaagtcatca
     1561 aagaaaggac ttgtggatct atcttgtgct ctatatcctg gggttaggcc atttaaaata
     1621 gaattggcag gatcggattt catgatttga taacaatttt gacagagatc aacctgtctt
     1681 tgttttccat taacacttgt ataaagatga atagtagatt cgtttaaatt acaattttga
     1741 cacagcataa tatacctccg agggtttatc taaaagtcaa agtcatttag tcaaaaatgg
     1801 tcaaagttta tattcatatt atagcaccac ggcttgggaa atcaagtaaa aagtttatcg
     1861 ctttagcgtt agcttttaga gagtaacatg acagagtaac tttattaagt ttccaatgag
     1921 caaatgttta aaatcattga aaagagtaaa aaaagtaaaa tatcaataaa tatattactt
     1981 tccttgttag tttcccttgt tttgtgttaa aataagaggg ataaaaaacg aataggagaa
     2041 acgaaatgga atcacatttg gtgagaatca tcaatcgttt ggagttgatg gtgacagatg
     2101 gcggtaatct caagcgaaat tttgaacgcg atggtgttgt tgttgcagaa gttgcctttt
     2161 caaatgatcc tgaaaatgga cctgttttca cattgcgtga tgttgaagcg cgtgagtcat
     2221 attcctttga tagtattgac ttgattgcaa tggaaatcta cgatttatta tattaagctt
     2281 gacatagtaa agagacttgc ctgaggcagg tttttttatt gtcaaaaagt attgtattaa
     2341 tattcatcag atggtataat tatctttatt gtaatgaacc taggacttat gaggagatat
     2401 aaatggattt gtcatttttg cccaaatact gggcctactt taactacggt gtacttgtca
     2461 ccattatgat ttcagtcagc gttgtctttt ttggaaccct tattggtgtc ttggtaaccc
     2521 tgattaagcg tagtcatgtg aagccgttga cctgggtcgt taatctttac gtttggatct
     2581 ttcggggaac acctatggtg gttcaaatca tgattgcctt tgcttggatg cattttaaca
     2641 atatgcctac tattggtttt ggggttttag acttagactt ttcaagacta cttcctggaa
     2701 ttattatcat ttcattgaat agcggtgctt atatttcaga aattgttaga gcaggtattg
     2761 aggctgtacc aaaagggcaa ttagaagcag cttattcact aggtattcgt cctcaaaatg
     2821 ccatgcgtta tgtgattttg cctcaggcct ttaaaaatat tttgccagcc ttaggaaatg
     2881 aatttattac cattattaag gatagtgctc ttttacaaac cattggagtg atggaacttt
     2941 ggaatggtgc ccaatcggtg gtaacggcta cttattctcc aatttcccct ttactggtgg
     3001 ctgcttttta ctacttaatg gtcacaacag tgatggcaca gttattggca gtcttagaac
     3061 gtcacatggc gcaaggaggt aatcattgat gactgaggct attatttcaa ttaaagactt
     3121 gcacaagtat tatgggcaca atgaagtgct taagggaatt gatttagaca ttatgccagg
     3181 agaggttgtg gtgattattg gcccttctgg ttctggaaaa tcgaccttac ttcgaactat
     3241 gaatcttttg gaagtaccaa ctaagggaca gattaggttt gaggggattg atattaccga
     3301 taagaagaat gatattttca gcatgcgtga aaaaatggga atggttttcc agcagtttaa
     3361 cctctttccc aatatgacta ttttagaaaa tatcacttta tcgccaatca aaactaaggg
     3421 aatggctaac gcagaggctg acaaaacagc cttgagcttg ttggacaaag ttggattatc
     3481 agaaaaagcc aaggcttatc ctgctagtct ttctggtggg caacagcagc ggattgcgat
     3541 tgcgcgtgga ctggctatgg atccagatgt tttactcttt gatgaaccaa cttcagctct
     3601 agacccagaa atggtgggtg aggtcttggc tgtcatgcaa gatttggcta aatctgggat
     3661 gactatggtt attgtgactc atgaaatggg ctttgctaaa gaagtcgcag accgtgtgat
     3721 ttttatggat ggcggcgtta ttgtggaaga aggaagtcct aaccaacttt ttgatctgac
     3781 taaagaagaa cgtacaaaag attttttgag tagagtatta taaatctgtt ctatgaatta
     3841 taaaaggaag tcctaaatga tttaggactt ccttttataa tttgctaagg cattttatag
     3901 gagattactt ttctttttgt taaaataaaa agaaatagtt acattatttg catagaagaa
     3961 agggatctgt tatggtttca gtgatgtggt ttcgtagaga tttaaggatt gatgatcaaa
     4021 aagctttagc tcatgttatt gctagtcaat caccaacctt atgtgtgttt caatttaaca
     4081 aggagcaatt aaatctgcta catagtcgga atcaatctag ttttattact agcgttttgg
     4141 cttttagaaa gttattaaaa tgtgaaggta ttgacttata tctaatgtat ggagacttaa
     4201 tgacctgttt tgagcaatta ttgacacaat taaaagactg gacagatgtg tattttaact
     4261 atgatgaatc tggatatggt cgtttacgtg atcaaaaagc agcacaattt ttcaaaaaaa
     4321 atgggattgc cgttcatacc taccaagatc actatttaca tggtagtcaa gagatcatta
     4381 accaatcagg tcagccttat aaagttttta cgccctacta taggatttgg caaaattatc
     4441 cgaaagagac tcctattaaa gtagaactat cgcaaggcag gtggttaaat cttgagacac
     4501 cagatgatgt tttaaggact gttgagagct ttaaagatga aaaatatcag gatgttgcaa
     4561 cttttgatga agcgtcaaaa caactaaatc gatttattca agaccaatta gcagcttatc
     4621 acgctaatcg agattttcca gcgcagctag ggacgagtcg gttgtctcct tttttaagaa
     4681 taggagctat tggcattcgc acggtatatc acgctgtgcg tcaagcacca aatagtctag
     4741 ggcaagctac ttttttaaaa gaattagctt ggagagactt ttacaatatg gtctatgtgg
     4801 cttatcctga tcagaaaact cagcctatcc aaaaagcctt ttctcaaatc gaatgggtta
     4861 ataatcctga ctggtttcag ttgtggaaag aaggtaaaac gggttaccct attgttgatg
     4921 ctgccatgct tcagttacaa aagacaggat ggatgcataa tcgtttacga atgatagtag
     4981 cttctttttt aactaaagat cttttatgtg attggcgttt aggagagcag tattttcaac
     5041 aacaactaat tgattatgat gctgccagta atatcggagg atggcagtgg actgcttcca
     5101 ctggaacaga tgctgttcct tattttagaa tatttaatcc tgttactcaa ggtaagcgct
     5161 ttgatcccaa aggcgagttt attaaagcgt atttgcctca actagaacac gttccagaga
     5221 agtatctcca cgaaccgtgg aagatgccaa aaaaccttca agagagtgtg tcctgtatta
     5281 ttggtacaga ctatgctcaa ccaattgtcg atcatgctaa acaacgtgaa caagctattg
     5341 caaagtatga gtgggcaaaa gaaaaagcaa aaatagaatg actgttctca ttataagagt
     5401 ttaaacaaaa agttatcatg aattaagatt atttaattta aaaaataagt tgactttatt
     5461 tagattattt gatactattc agttgtctcc cttagagaaa gcgatttctt gttttggagc
     5521 tgatttttac catttggtct tagaatagga tgagtaatat gacttacaac gaggtatatc
     5581 aagaatggtt gcacaataat gatcttagtg atgatattaa agcagattta gcagccataa
     5641 aagacaatga ggctgagatt caagatcgtt tttacaaaac acttgaattt ggaacagcag
     5701 ggctaagagg aaaacttgga gcaggcacca atcgcatgaa tacctatatg gttggtaagg
     5761 cagcacaagc tttagctaat actattattg atcatggacc tgaagcagtt aaaaagggca
     5821 ttgcggttag ttatgatgtt cgctatcaat ctagaacatt tgcagaatta acatgctcta
     5881 ttatggcagc taacggtatt aaggcgtacc tttataaagg gattcggcca acaccaatgt
     5941 gttcgtacgc tattcgtgct ttgggatgta tctctggtgt tatgattacg gctagtcaca
     6001 atcctcaagc ttacaatggt tacaaagctt attggcaaga aggttctcaa attttggatg
     6061 acattgcgga tcaaattgca caacacatgg ctgcactaac tcagtatcag gaaatcaaac
     6121 aaatgccttt tgaaaaggct ctggacagtg gacttgttac ttatattgat gaaagtattg
     6181 aagaagcata taaaaaagaa gtgcttggtt taacgattaa tgatactgac attgataagt
     6241 cagtccgagt agtctatacc cctttaaatg gtgttgggaa tctaccagtg cgtgaggttt
     6301 taagacgccg cggttttgaa aatgtttatg tggtacctga gcaggaaatg cccgatcctg
     6361 attttacaac agttggctat cctaatcccg aagtccctaa aacttttgca tattcagaaa
     6421 aattaggtaa ggcagttgat gctgatattt tgattgcaac tgatccagat tgtgaccgtg
     6481 tggctttaga agttaaaaat gcagtcggtg actatgtttt tctcaatggc aataaaatcg
     6541 gagcgctttt atcttactat atcttttcac aacgatttga cttaggcaat ttaccggcta
     6601 atcctgtttt agtgaaatcc attgtaacag gagacttgtc acgggctatt gctagccatt
     6661 atggtattga aaccgttgaa acattgactg gttttaagaa tatttgtggc aaggcaaacg
     6721 aatatgatgt gacgaaacaa aaaaactacc tgtttggtta tgaagaaagt attggttttt
     6781 gctatggcac ttttgttcgt gacaaagacg ctgttagcgc ctctatgatg attgtagaaa
     6841 tggcagctta ctacaagaaa aaagggcaga atttactaga tgttttgcag actatttatg
     6901 cgacatttgg gtattataat gaacgtcaaa ttgccttgga gcttgagggg atagaaggac
     6961 aaaaacgcat tgcgaggata atggaagatt tcagacagac accaatagct agtgttgcag
     7021 agatggcgtt agacaagaca attgatttta ttgatggcta tcaagatttt ccaaagcaaa
     7081 actgtctcaa attttatttg gatgatggtt cttggtatgc acttagacca tcaggaacag
     7141 agcctaaaat aaaattttat ttatatacta ttggccaaac acaagaaaat agtgcaacaa
     7201 aattagatgc tattgaagca gcgtgtcgca caaaaataaa tcaggttaat taaacatcaa
     7261 aaatggataa cacttttaca ctatttttcc atataaacaa ctacaaaagg aggtgagact
     7321 tttaggcacc ttctttttct tgtaggtgcc actaatcaat ttaatcgact caaaccaata
     7381 ctaaaaaata agtaagagta taaagaacag gcatctattt ttttgttata atagaaaaat
     7441 gaaattaaag ggagatgtca atgacagaac taattgatgg taaagcctta gctcaaaaga
     7501 tgcaacaaga gttagcagct aaagtcaaca atctaaaaca aaaaaaagga attgtaccag
     7561 gcttagccgt tattcttgta ggtgatgatc ctgctagtca ggtgtatgtc cgtaataaag
     7621 agcgtgcagc tcttactgta ggttttaaaa gtgagaccgt tagattatca gaattcattt
     7681 gtcaagaaga gcttattgca gtaatcgaac gttacaatgc agataacact attcatggta
     7741 ttttagtgca gctacccctg ccaaatcata ttaatgataa aaaaattatt ctcgccattg
     7801 atcccaaaaa agatgtggat ggttttcacc cgatgaatac aggtcacctt tggtcaggac
     7861 gtcccttaat ggttccttgt actccatcag ggattatgga attgcttcga gaatataatg
     7921 ttaaccttga aggtaaacat gccgtcatta ttggcagatc gaatatcgtt ggaaaaccaa
     7981 tggcacagct cttactagac aaaaatgcaa cagtcacgtt gacacattca agaacacgtc
     8041 aattagaaga agtatgtcgc tgtgcagatg tgttgattgt ggcaatcgga caaggtcatt
     8101 tcataacaaa acaatatata aaagatggtg cgatagtgat tgatgtggga atgaaccgtg
     8161 atgataatgg caagctaatt ggagatgtgg cctttgatga ggtggcagaa gttgcagcga
     8221 aaatcacccc tgtaccagga ggtgtcggtc ctatgacaat tgctatgttg ctagagcaaa
     8281 cttatcaatc tgccctccgt agtactcata aatagttata attagacaat tcaacataag
     8341 agaatataag aagtcagcaa tggcttcctt ttttgttttt ctgctcacta tttatccaga
     8401 aaaatggtat aattgcatta gtatgcaaag ggactatgtc aggtccaact aagtgaaagg
     8461 tggcttgatg gcagattatt taaccgtcac tcatttgacg aaatatttaa aattaaaatt
     8521 tgaccgtgac ccttatttgg aacgggttta tctgactggt caagtgtcca attttcgaaa
     8581 acgaccaact catcaatatt tttccttaaa agatgaaagt gctgtgattc aagccaccat
     8641 gtgggcagga gtctataaaa aactaggatt cgacctagaa gaaggcatga aaattaatgt
     8701 aattgggcga gtccaacttt atgaacctag tggctcttac tctatcgtga ttgaaaaggc
     8761 agagccagat ggtataggtg ccttggcttt gcagtttgaa caattaaaga aaaaattaac
     8821 ggcagaaggt tattttgagc aaaaacacaa gcagcccttg ccacagtttg tatcaaaaat
     8881 tggggtcatt acaagtccta gtggtgctgt gattcgagat attatcacaa ccgtttcacg
     8941 gcgttttcca ggggttgaga ttttattatt cccaactaaa gtacaaggtg atggagccgc
     9001 ccaagaagta gtggctaata ttcgaagagc caatcaaaga gaggatttgg acttgctcat
     9061 tgtcggccgt ggaggtggct cgatagaaga cctttgggcc ttcaacgagg aaatagtggt
     9121 tcaggctatc tttgaatcgc aacttccagt gatttcgagt gtgggtcatg aaacagacac
     9181 gactttagcg gattttgtgg cagatcgcag agcagccaca ccaacagcag cagcagagtt
     9241 agcaacgcct attacaaaaa cagatcttat gtcttggata gtagagcggc aaaatcgttc
     9301 ctatcaggcc tgcttgaggc ggattaagca acggcaagag tgggtggata aactctcgca
     9361 atctgttatt tttaggcaac cagaacgatt atatgatgcc tacctgcaaa aaattgatcg
     9421 ccttagcatg accctgatga atacgatgaa agatcgtctg agttccgcca aagaaaacaa
     9481 ggttcagttg gaccattcct tggccaatag tcaattacag acaaaaatcg agcgatacca
     9541 agaccgtgtt gctaccgcta agcgtttact gatggctaat atggctagtc aatatgatag
     9601 tcagctggct cgctttgaaa aagcacagga tgctttgcta tcactggatg ccagccgaat
     9661 tatcgcccgt ggttatgcaa tgattgaaaa aaatcaagca ctggtagcct ctgtaagtca
     9721 gataacaaag ggtgatcagt taaccattaa gatgcgtgat ggacaattag atgtagaggt
     9781 aaaagatgtc aaaaacgaaa acatttgaag aaaatttaca agatttagag actattgtga
     9841 acaaacttga aaatggggat gtccctttgg aagaagctat ttcagaattt caaaaaggaa
     9901 tgcttctctc aaaagaactt caaaagacct tacaagcggc agaaaaaaca ctcgtcaaag
     9961 tgatgcaagc tgatggcaca gaagtagata tggatgatta atggacaaat tagctagaat
    10021 tgacgaagcc attcgtcgct actataagac gactagtaac ggtgtatctg aagagttgat
    10081 tgatgctatc ttgtattctg ttgacagtgg tggcaagcgc attcgcccac ttatcttatt
    10141 agagatgatt gagggatttg gggtatcgtt acagaatgct cattttgatt tggctgcagc
    10201 ccttgaaatg attcatacag gaagtctgat tcacgatgat ttgccagcca tggataatga
    10261 tgattaccga cgtggtagac tgaccaatca caaacaattt ggagaggcta ctgctatttt
    10321 ggcgggagat agcttatttt tagacccctt tgggttaata gctcaagctg aattaaatag
    10381 cgaggttaaa gtagccttaa tccaagaact ttccctagct tcaggaactt ttggcatggt
    10441 tggtggtcag atgctagata tgaaagggga aaatcaagct ttgagtctcc ctcagttgtc
    10501 actgattcac ctcaataaaa ccggaaaatt attaactttt ccttttaaag cagcagctct
    10561 tgtaacagaa caggctatta ctgttcgtca acaactagag caggcgggaa tgctcatcgg
    10621 gcacgccttt cagattaggg atgatatttt agacgtgaca gctagctttg aagatcttgg
    10681 aaaaacgcct aaaaaggatt tatttgcaga aaaagctact tacccaagtt tattggggtt
    10741 agaagcctcc taccaactgt tgacagagag tttagatcag gctttgacga tttttcagac
    10801 actcgaaagc gatgtaggct ttaagcctca aataattaca aaactgatag aagggttacg
    10861 acttaatgcc taaagaaaga gtagatgtgt tagcctataa gcaaggatta tttgagacca
    10921 gagagcaagc taagcgtggt gttatggcag gcttagtggt ctctgtgatt aatggccaac
    10981 gctatgacaa gccaggtgac aaaattgacg atgggactga gttaaaactt aaaggtgaaa
    11041 aactcaaata cgtcagtcgt ggtggattaa aactggaaaa ggggctgcac gtttttggtg
    11101 tatcggttgc taatcaaatt gggattgaca ttggcgcttc aacaggtggt tttaccgatg
    11161 ttatgttaca agatggggcc aaactagtct atgccgtcga cgttgggact aaccagttgg
    11221 tatggaaact cagacaagat ccacgagtaa gaagtatgga acagtataac tttcgttatg
    11281 ctcagccaga ggactttagt gagggacagc ctgtatttgc cagtattgat gtgtccttta
    11341 tttctctcag cttgattttg ccagccctgc ataacgtttt gtcagatcag ggacaggtta
    11401 ttgctctcat taaaccgcaa tttgaagctg ggcgcgagca gattggtaaa aaaggcatcg
    11461 tcaaagacaa acagattcat gaaaaagtga ttcaaaaggt catggatttt gcctcaggtt
    11521 acggatttac agttaaggga cttgattttt cccctattca gggtggtcat ggaaatatcg
    11581 aatttttagc tcatcttgtt aagtcacaga cacctgaaac gttagcccca catctgattc
    11641 aggaagttgt tgccaaggca cataaggagt ttgagaaaca tgaaaaaaag tgaacgactt
    11701 gaattaatca aaaaaatggt tttgacgcat ccaattgaga cgcaacatga cctcttaaga
    11761 ttattggcag agcatgggtt agaattaacc caggctacta tttcaagaga catgaatgaa
    11821 attggtatag taaagattcc ttctggcagt ggacgttaca tctatggtct ttctcaagat
    11881 agtggaaaaa agatcgttca aggacctaga tcgataaaga gcactatttt agctgtatct
    11941 gacaaaacaa aaggtttaga acaacacctc tatttaaaag tcgtacctgg caatagtaaa
    12001 ttaatcaaac gttatttatt agcagatttt tcaaaagcta tttttagtct tattgctgat
    12061 gatgatagtt tactgttaat tgcaaagtct ccttcagaag cagatatgat acgccaagaa
    12121 attttgcttt ggatgcaggg tataacctag aaaaaaatag gggagaaagt gatgttatta
    12181 gaaatttcca ttaaaaattt tgctattatt gatgaaattt ccctaaattt tgaaaatggt
    12241 atgacggttt tgacgggtga aactggagca ggaaagtcta ttatcattga tgctatgaat
    12301 atgatgcttg gtgcgcgtgc tagtacagaa gtgattcgtc gtggagctaa taaagcagaa
    12361 attgaggggt tcttttcggt agatgctacc ccagaactgg ttgcgtgtct ggaatcatca
    12421 ggtattgcta tggaagaaga actgattatt cgccgagata tctttgccaa tggcagaagc
    12481 gtgagccgca ttaatggtca gatggttaac ctagccgcct taaaacaggt cggacagttt
    12541 ttggtagata ttcatgggca acatgaccaa gaagaattaa tgcgaccaca gctccaccag
    12601 caaattttgg acgcttttgg tgataaggct tttgagcaat tgaaagagaa ctatcagctt
    12661 atttttgatc gttataaaag cttgcgtcgc caggttattg acaaacaaaa aaataaaaaa
    12721 gaacataaag atcgtatcga catgttggct tttcagatag cggagattga agctgctgcc
    12781 ttgagtcgag gtgaggacga ccggttaaat caagaacgtg atcgcttaat gaaccacaaa
    12841 caaattgctg ataccctgac caatgcctac gtcatgctag ataatgacga tttttcaagt
    12901 ctatccaata ttcgctctag catgaatgac ttactatcaa ttgagcagtt tgattcagag
    12961 tacaaaggga tgtcgacttc gatttctgaa gcctattata ttcttgaaga agtgagcaag
    13021 caattatcag ataccattga ccaactggat tttgatggtg ggcgattaca ggaaattgaa
    13081 tttcgcttgg atacactcaa tagcttaacc cgtaaatacg gtggtaatgt gaatgatgtg
    13141 cttgactact acgataatat tatcaaagaa taccagctat taacaggaga tgacttgtct
    13201 tcaggggatc tagaggcaga attgaaaagc ttggaaaaac aattggttgc tgctgcttcg
    13261 gagttaagtg tctctcgcca tcaattggcg gagcaattag aagctgagat taaagctgaa
    13321 cttaaggaac tttatatgga aaaagcagat ttcaaagttc actttaccac atcaaaattc
    13381 aatcgtgatg gtaatgaaag cttggaattt tacatctcta ctaatccagg cgaaggattc
    13441 aagccccttg tcaaggtggc ttctggagga gagttatcac gccttatgtt agccatcaag
    13501 gctgctattt ctagaaaaga agataagacg agtattgttt ttgatgaagt agatacaggt
    13561 gtttctggtc gcgttgcgca agccattgcc caaaaaattt ataaaattgg gcgacatggg
    13621 caagttctcg ctatttcaca cttacctcaa gttattgcta ttgctgatta tcagtatttt
    13681 atttctaaag aaagtaaaga agagtccacc gtttctaagg taaggttatt aactcctgaa
    13741 gaacgtgtgg aagaaattgc tagcatgatt gcaggaacag atatgacaca agctgctctt
    13801 acgcaggctc gtgaactact tgccaagcat taagattatg tttggtattt gatattttca
    13861 taattagatg aaattgattt tttaggtgct aaaataatca ttgtgttaga ccatttttcc
    13921 tctgttaatc tggcttggtt tgccttgaca aacctctgag aaatagtaga atagataaga
    13981 gaattttaag ctgaggggat agaaatgact agtaaaaaag cgtgtttatc aagcatcatt
    14041 gtgttagcaa gtttaacgtg tggaaatgat actgttagtg ccaatcatct ctcagcaact
    14101 ggagataagt ttgatgattg ctcaacactt gttgaaaaag atgtggcccc taaagatgaa
    14161 cttgagatgt tagcatggtc ctcgtctcaa acaactgatg atgctgacag agactatgaa
    14221 gattttctcg atgatgattc ttttaatgat gattctttta tttctcaaaa tgaaactgat
    14281 aagatgtttg agaatttaac tgatgatagg ttattaaatg aattagatga atcagatgaa
    14341 gaagatgaag aagatgaaga agatgaagaa gatacaattg agccagagca aaatgtaata
    14401 atgcctagtg acgatgagct atttgattta actgatgctg ttgagacacg ccttactgtt
    14461 tctagtgctc cccatttaga ggctgaattg ccgaaaccac atttgaggag cctatcagat
    14521 acagcactgc ggtctggtga aattagagga catttagata acaaactgga cgctttgtct
    14581 gtaacagcta caaagttagc attaacgatg gctcaaaaat ttgatttgac aacgcatgtc
    14641 tattctatag gtgaaagctt tagtgaagta ttagctgctc attatgaaga tagaaaagca
    14701 gaatcagctt tttctaagaa aaagagattt caccttccta ttgctactcc agatgttgtt
    14761 atagaggagt taaggcgcct agtctcttct attggaagtt caaaagaaga tgtttcagtt
    14821 ccttataatc ggaagctagg tatggcagtt gcaaaaagaa aaatagccct gccacaaacg
    14881 ggagaggggt tctcttatta tccagcttta cttggtttaa tgatattagg attaacgccg
    14941 attatgatac caaagaagat aaataattag gtaataagtt attgtagttg taaaagacgg
    15001 ggcaaatgtt caagcgtgaa aaggttgact tttgcctcgt tttgtatctc gttattgcta
    15061 aggcattttc ttcgagcagc tagtgctcgc catacctatc taccgagtga ttattcaata
    15121 gcactaccag ttttgcttta tttagtaagg agtgttagaa taaagaggtg agaaactagt
    15181 ttagaatgga aaaatacatg ggaactataa aaattgttac agattcatca ataactattg
    15241 aaccagaatt aattaaagct ttagatatta ctgtagtgcc tttatctgtc atgattgata
    15301 gcaaattata ttctgataat gatttaaaag aagaaggtca ttttttgagt cttatgaagg
    15361 ctagcaaatc ccttcccaaa accagtcagc caccggttgg tctctttgct gaaacttacg
    15421 aaaatttggt caaaaaagga gtaactgaca ttgttgctat tcacctctca ccagctttat
    15481 caggtactat tgaagcttcc cgtcaggggg ctgaaatcgc tgaggcacct gttacagttt
    15541 tagattcagg atttactgat caagccatga aatttcaggt cgttgaggca gcaaagatgg
    15601 caaaagcggg tgctagtttg aatgagattt tggctgctgt tcaagctatc aaatcaaaaa
    15661 cagagctcta cattggtgta tctaccttag aaaatttagt aaaaggaggt cgtattggtc
    15721 gtgtgacggg tgttttgagc tcgctactta atgtcaaagt tgttatggca cttaaaaatg
    15781 atgagttaaa aacgcttgtc aaaggtcgag gtaataaaac atttacgaaa tggttagata
    15841 gttacctcgc taaaaatagt catcgcccga ttgcagagat agctatttct tatgctggtg
    15901 aagctagcct ggcattaacc ttaaaagaaa gaatcgcagc ttattacaac cactctattt
    15961 cggttttaga aacaggctct atcatccaaa cacatacagg agaaggagct tttgcggtta
    16021 tggttcgtta tgaataatcg tcatttattt agtgggatat ttttctttgt tattagttta
    16081 tgtctggcct ttttattgct aaatattatt atccctaagt caaattcacg tttgaaaaag
    16141 agtgattttc tgaaaaaaga acaagtagct atccaatatg ttgctatagg agattcattg
    16201 acagaaggag taggtgatct aactcatcaa ggtggttttg ttcctttgtt aacgaatgat
    16261 cttagtgaat attttaaggc taatgttaat catcaaaatt acggcgtatc tggtgatacc
    16321 agtcaacaaa ttcttgatag gatgataaaa caaaagcaga tacagttatc tttaaaaaaa
    16381 gcagatataa tgacgttaac cgttggtggt aatgatatta tggcagttat tcggaagaat
    16441 ttagcggatt tgcaagtttc tagttttaga aagccagctc gtcagtatca aaaacgatta
    16501 agacagatta tcgagttagc cagaaaagat aataaagatc ttcctatttt tattttaggc
    16561 atctataatc cgttttattt gaattttcca gaactaactg atatgcaaaa agtgattgat
    16621 gactggaata ccaaaactaa ggaggttgtt ggagaatacg atcgtgtgta ctttgtgcca
    16681 ataaatgacc tcttgtataa agggataaat ggacaagaag gaattgtcca ttcttcagga
    16741 gatcaaacta caattgtcaa tgatgccttg tttactgggg accattttca cccaaataat
    16801 actggctatc aaatcatgtc aaatgcagta atggagaaaa taaaaaagca tgaaaaaaaa
    16861 atcaaacctt aattggtgga agtggagctt cttatgtctg cttgctttta ataccgcctt
    16921 tttgatggtt attgcaagtc gtctcattca agtaagagaa cctgagtcag aactgattgc
    16981 taaaaaacca gttaaaaata tcaaaattgg tacatttgtc acaaccagag aacagcttaa
    17041 cgaaactgta gcaagttatc ttaaagatta tcagactaaa aaaatgtctt ataaatttta
    17101 tgcgacatct tcttctattt tgtttgaagg aacttatcaa ttattagggt atgaagtccc
    17161 tttatatatc tattttcaac ctcatcgtct agaaaatgga gctgtccaac tacaggtgat
    17221 ctctttttca gtgggaactc tgccactccc agaaaaagat gttttgcagt atttgaaatc
    17281 aagctacaaa ttgccaagct ttgttaaagt gatgccaaat caatcagcta tcgttgttaa
    17341 tttacaagat atccaaaatg atgctaaggt ttatttaaag gccaagaaaa ttgatttatt
    17401 taatgatgaa atcagtttta acatctataa gaaataacct caaataacgt taaatacttg
    17461 acctaatcgc tttttttaga tatgataata tctgttaaag cattaagctt actaattatt
    17521 tggaggattt gttaaatggc taacaaacaa gatttaatcg caaaggttgc agaagcaact
    17581 gaattgacta aaaaagattc agcagcagca gttgatgccg tgttttctac aatcgaagct
    17641 ttccttgctg aaggtgaaaa agtacaattg atcggttttg gtaacttcga agtacgcgaa
    17701 cgtgcagctc gtaaaggtcg taacccacaa actggtgcag aaattgaaat tgcagcttca
    17761 aaagttccag ccttcaaagc tggtaaagct cttaaagacg ctgttaaata attgcatata
    17821 taaaagccca ttgtacaagc gttgtagcct gtgcagtggg cttttttgtg ttcagggggg
    17881 taaaaaaggg gtaaaaaatt taatagtttt ccataatatc agctacactt gatttcattt
    17941 tctttgtgac atgagtataa atttgggcag tagttttagc gtctgcatgt cctacacgtt
    18001 ccatgattga ttttagcggc acgttattct ctgctagacg gctaataaga gtgtgacgga
    18061 agatgtggct agtaagtttt tttgtaattg ggtcttccaa tctttcatta gcttttttta
    18121 aagctaagtt gaatgagtta gtctgaattg gaacaccgtt ttttgttgta aaaaggtatc
    18181 ccatatctct atatctatga tttgtatttt tttctagttc gttcataaat tctaactctt
    18241 gtagaatttc aagttctcta cttgtcatga tggtttcacg ataagaagct aatgtctttg
    18301 gtgctgtctt ttccccgtta cgatatcctt ctgtatgatc aaatgttccg tgcaactgca
    18361 atattcttga cttagattcg tagttgcacg gctcaatgct gacagcttca ccgatacgac
    18421 aaccgttcaa actgataaac tcagccaaca aaccaagtcg gtaagtgcta ggtcttctgt
    18481 acaattcttt caataatggt ttaatttcat cttcttcaag atatttttct tcagcctttt
    18541 tccagtcttc aagagttttc tttacccttg ggagtttagc acgtcttgca ggattatctt
    18601 ggataatatc caaaccaaca gcataatcaa atgctaagtt tagcatagac ttattacgct
    18661 cttttttatt cctagagcaa tctaggttat cgagataatt ctgaacgtat ttaggatcaa
    18721 tattcactac tttaacacct attccaaaag tttcccttat ctcttcgata ttacctctca
    18781 gagaagctac agacgacctt ttaagttctt tcttataaaa cgcccaccat tcatctaaaa
    18841 gttccgtgaa aagtaactca gaggccttta attgcgctat tttttctgtt attttttgtt
    18901 caaggatttt tcgagctgct ttataagctc ttgaattatc cttctccata gtaacggata
    18961 caggtttcca tgttccagtg taaggatctt tataattttc acgaaatttg aatttaccgt
    19021 tatcagtttc ttctatccac atttgttttt tacctcattt tctgttaaaa taggtatagt
    19081 aaagagacct actgcgaagc aggtttttac tatactagat tcgcctcacg ctctcctcgc
    19141 caaatttgag cgtggggctt ttttgttagt tgagaaacca agatgctatc gactctaata
    19201 atccagcatt tttacttttt gatactctat ctacttttaa aatagtcaat cgtaacttat
    19261 aagttatatc tttcttttta gtaaccacgg tctttaaatc gtttttgagt gttttgtatt
    19321 gtccaccacg accagtaagg gttgcttcca tttggtaatg actagatttt tttacataag
    19381 gggttaatcg tttagctaag tctgctggaa agtagccaac aaaagttttg tttaccatga
    19441 cttttatggc atttggatcg tgacgattaa gaggttctct gacaacctct acatcttttg
    19501 ttgagaccct gtaatacttg tagatatcct tgaagtttga ttttatgtag tcagaaataa
    19561 aatctttatc cttatcccag tatggtgatt tcttaccaat ttcagccata actttattag
    19621 cttctttttc atgataattt gttcccatta agagaaagtt atcttggaat atgacttttg
    19681 ccataacagt ctcctttaat attccctata aatatccaca acttcaccga ttgtgcggat
    19741 gtcgtcatcc tttgatagat agatttcctc atagctttta tttaaacttt gcaagtacca
    19801 agcgccatca taatcacgct tgagtttttt tacaaagttt ttaccattga cttggaatat
    19861 ccctatatca ttcatatcga cttggctaga taccttgatg aatagcaaat cgttgtcttg
    19921 aataagtggt tccattgaat cgccagctac ttttgcaata gtatcatact catcggggac
    19981 atcatcagaa cgtagtttaa ctttcatgtg taaattgtct tcttggtatg ccccaagacc
    20041 agcggcaacc aatccctcaa cgtagtcagt gatataatct tctgtctcct cagatttttt
    20101 atcgaatata gaaacggttt tattttgttc ttctaattgt tcgttagcga agttgaggac
    20161 tttttcttgt ctaggttgtt ctagttggtt gtatatagaa acgatttcag gttgttcgtt
    20221 ctgtattgtg attttcccaa gtttactatc tgtgagtcct aaaagatagt cagaggtaac
    20281 gttgaaaatc tctgctagtt tttttaggtc tttacctttt ggaaaatttt cattcttctc
    20341 ccactttgaa acagtagtat aggttttcat gcccaatatt tctgaaagtt cagtctgagt
    20401 catgttgcgc ccttctctca actttcttat tcggtcccct aattgctcca taggatacct
    20461 cctttttaat tttgataagt aaattatatc aaaaccatga ttataaatca accatataag
    20521 aaaaaagttt taaataaact atatgattta cgattttttc aaaaaaacag aaaataaatc
    20581 atataaaaca cttgacgcaa gatttaaaat catatagaat gtaatcatca tcaagaaagg
    20641 agcgactcag ctatggtaac tattgcagaa ttaagagcta aacataataa gatgtcacag
    20701 cgtgaattgg caaaagaatt aggtgttact caaacatcta tcagcaactg ggaaaaagac
    20761 cagacaaaga tttcaggtga gtatcttatt agtctagctt tgtttttcga tgtatctacc
    20821 gatgacattc ttgggataaa caagcaagca acacaaaaat tttaaacact ata
//
