LOCUS       NZ_LS483337            24230 bp    DNA     circular CON 13-FEB-2024
DEFINITION  Streptococcus pyogenes strain NCTC12047 chromosome 1, complete
            sequence.
ACCESSION   NZ_LS483337
VERSION     NZ_LS483337.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Doyle,S.
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 01:05:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,789
            CDSs (total)                      :: 1,700
            Genes (coding)                    :: 1,640
            CDSs (with protein)               :: 1,640
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 29 of 60
            Pseudo Genes (incomplete)         :: 31 of 60
            Pseudo Genes (internal stop)      :: 23 of 60
            Pseudo Genes (multiple problems)  :: 19 of 60
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:22:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 831469
            Orig. end                         :: 855699
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LS483337.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24230
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24230
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24230
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14230](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14230
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(88..1464)
                     /gene="mnmE"
                     /locus_tag="DQL03_RS04325"
                     /old_locus_tag="NCTC12047_00851"
     CDS             complement(88..1464)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="mnmE"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002888396.1"
                     /locus_tag="DQL03_RS04325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00851"
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="WP_010922268.1"
                     /transl_table=11
                     /translation="MSITKEFDTITAISTPLGEGAIGIVRLSGTDALAIAQSVFKGKNL
                     EQVASHTINYGHIINPKTGTIIDEVMVSVMLAPKTFTRENVVEINTHGGIAVTNEILQL
                     LIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMTIAVKQLDGSLSQLI
                     NDTRQEILNTLAQVEVNIDYPEYDDVEEMTTALLREKTQEFQSLLESLLRTAKRGKILR
                     EGLSTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNIKGVPLKLVDTAG
                     IRETDDLVEQIGVERSKKALQEADLVLLVLNASEKLTDQDRALLNLSQDSNRIILLNKT
                     DLEQKIELEQLPDDYIPISVLTNQNINLIEDRINQLFFDNAGLVEQDATYLSNARHISL
                     IEKAVQSLEAVNDGLALGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLFSQFCLGK
                     "
     misc_feature    1635..1770
                     /db_xref="RFAM:RF00557"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
     gene            1799..2299
                     /gene="rplJ"
                     /locus_tag="DQL03_RS04330"
                     /old_locus_tag="NCTC12047_00853"
     CDS             1799..2299
                     /GO_component="GO:0015934 - large ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012658294.1"
                     /locus_tag="DQL03_RS04330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00853"
                     /product="50S ribosomal protein L10"
                     /protein_id="WP_002984821.1"
                     /transl_table=11
                     /translation="MSEAIIAKKAEQVELIAEKMKAAASIVVVDSRGLTVDQDTVLRRS
                     LRESGVEFKVIKNSILTRAAEKAGLDELKDVFVGPSAVAFSNEDVIAPAKVINDFTKTA
                     DALEIKGGAIEGAVSSKEEIQALATLPNREGMLSMLLSVLQAPVRNVAYAVKAVAENKE
                     GAA"
     gene            2364..2729
                     /gene="rplL"
                     /locus_tag="DQL03_RS04335"
     CDS             2364..2729
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /locus_tag="DQL03_RS04335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="WP_002984819.1"
                     /transl_table=11
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAAAAAG
                     GAEEAAKDSFDVELTSAGDKKVGVIKAVREITGLGLKEAKGLVDGAPANVKEGVAAAEA
                     EEIKAKLEEAGATITLK"
     gene            <3027..3647
                     /locus_tag="DQL03_RS09215"
                     /pseudo=""
     CDS             <3027..3647
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /locus_tag="DQL03_RS09215"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="replication initiator protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AIYLIYSNSK"
     gene            3827..5639
                     /locus_tag="DQL03_RS09370"
                     /pseudo=""
     CDS             3827..5639
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237146.1,RefSeq:WP_001871971.1"
                     /locus_tag="DQL03_RS09370"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="SAG1250 family conjugative relaxase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKFLDLFAGIGGFRLGLINQCHECIGFCEIDKFARQSYKAIYETE
                     GEIEFHDIRQVTDQDFRQLRGQVDIICGGFSLVKHFHSQADDWDLRALGELSSLRLLER
                     LIQTKIIFIITS"
     gene            5790..6476
                     /locus_tag="DQL03_RS04365"
                     /old_locus_tag="NCTC12047_00861"
     CDS             5790..6476
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373772.1"
                     /locus_tag="DQL03_RS04365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00861"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002984807.1"
                     /transl_table=11
                     /translation="MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKG
                     YDLILLDIMMPNISGTEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIVKPFS
                     LKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYREYE
                     ILELLSRHPYKVFTKEEIYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGI
                     GYKWDV"
     gene            6469..7815
                     /locus_tag="DQL03_RS04370"
                     /old_locus_tag="NCTC12047_00862"
     CDS             6469..7815
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984805.1"
                     /locus_tag="DQL03_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00862"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_002984805.1"
                     /transl_table=11
                     /translation="MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSH
                     NVGEEFYIKDKQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVAEEKN
                     NLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIVVAL
                     TRFVKEISLNFKEIKKLANKMGIEVLSENENYSKIIEFDDILRTLHIKGDNLKSLIERE
                     ILEKQDLSFQIAALSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYF
                     NSLISYTRMLSEDRSVKLILVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEE
                     NLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFY
                     TEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI"
     misc_feature    complement(7844..7859)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.51"
                     /tool="antismash"
     gene            7972..8112
                     /locus_tag="DQL03_RS04375"
                     /old_locus_tag="NCTC12047_00863"
     CDS             7972..8112
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528609.1"
                     /locus_tag="DQL03_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00863"
                     /product="lantibiotic streptin"
                     /protein_id="WP_002984803.1"
                     /sec_met_domain="TIGR03731 (E-value: 8e-09, bitscore: 32.1,
                     seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNTIKDFDLDLKTNKKDTATPYVGSRYLCTPGSCWKLVCFTTTV
                     K"
     gene            8227..10017
                     /locus_tag="DQL03_RS04380"
                     /old_locus_tag="NCTC12047_00864"
     CDS             8227..10017
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418808.1"
                     /locus_tag="DQL03_RS04380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00864"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_111674915.1"
                     /transl_table=11
                     /translation="MIKAQLKNLIKTIHLVKEAGFSLLVFSIAISLFQGILPIFSMLLV
                     QKMLNIITTDIKNFHTLMIAFISYIALTLLTIIIGEVDSYIDTKLQILLHYKMNHLVMQ
                     KTVKLTLAEFETPEIYDDITRIQNQISYKPFQIYKSIISVLSSLVSLISSFVILLNWKI
                     SIFPLLLILPIVSIYIYLKIGKNEFEILYKRSSDERANWYISHLLTHDFAVKELRLGTL
                     ESYFLKKYDKNNQLFINQENSINRSKMKYGIVLGVLEIAIQSIIMFLAVREAFLGILLV
                     GNVTTFIRSLSTMQTSTQNIVNNIYSFYNGSLYMELLYDFTLDELVHNPIIESTVDTIQ
                     SVEFERVSFSYNGKDNVINDISFSIKAGERLAIVGENGSGKSTIFKLACGLYDNYEGNI
                     YINGINLRSIQKKSYYKRISALFQDFLKYELTLRENVGLGELSKLYSDEDLISALKYTG
                     VDSIFYFNQEKLNQIDLEQQLGNWFEDGRQLSGGQWQKIALSRVYLKEADCYLLDEPSS
                     ALDPESETKIFKTFFELSQNKIGIFITHKPSITQSVNKILYLDNGCISETGSFADLNIK
                     GMKFKNLLDKEIGATYDTSN"
     gene            10001..11245
                     /locus_tag="DQL03_RS04385"
                     /old_locus_tag="NCTC12047_00865"
     CDS             10001..11245
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989896.1"
                     /locus_tag="DQL03_RS04385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00865"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_002989896.1"
                     /sec_met_domain="LANC_like (E-value: 7e-78, bitscore:
                     258.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPQIKQIVDYIADSFINYEQIVAESENKVLINIESKYRNTFFDK
                     SLSHGVPSLILMYSSLYKVTKDERYLTFSNIYVEKLVDIISRDGIESPSLYAGTAGIAL
                     AIKEASISGKYYPKLLSSLNCLLKEQIKDKLVVSFSNIEKGIIEPYDYDMVNGFSGITN
                     YLLLEQEFFSVELNQIGNYLLKYIETILNKVTNCSEDREAEFDLGIAHGITGPMLILAK
                     LKSEKILSVEVGDILNKAINLMFLFRRDDKLWPGKIYTSNILDLDLNYLPTRMAWCYGT
                     PGTAVALFKMCQLIDLNFIDDINESLIAQMRSSDKNVYSLTMCHGLAGVTFIYDLIGKN
                     YSSERLTRFAEELRQQIITSFSTTKVFGYTDREKFGEIEVELESIGILQGVSGIVLFLL
                     NPYSDEELLWQRIFI"
     gene            11264..14230
                     /locus_tag="DQL03_RS04390"
                     /old_locus_tag="NCTC12047_00866"
     CDS             11264..14230
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528611.1"
                     /locus_tag="DQL03_RS04390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00866"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_063662239.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2e-90, bitscore:
                     300.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.6e-11,
                     bitscore: 41.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-13, bitscore:
                     47.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKVFPTGMIRIPLQKQEFYNKDYEDLINDKVFMEQLLVASPSLY
                     DSVIDFDKCNEKKKQNVKVSLNSYSKRAAFRTTPFGIFTAINTVDLTKGTTSNVQKVSF
                     IKKAVPDYSWIYSLVKSYEISNLEKLSLKINTAAFTQGDRYVLPFTVNESEEDRNISFS
                     KPIKLLVEKCKTRYIKYEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPPICN
                     INSLDYLLSKLEEGTLCTDLTTLKKMIEDYNDLNIGEGRDLLLQIFDKMESIYKYDNGG
                     NYLKVDSLAEYEGDFNILSETARESIERLAEMFVKLNTNVKRRGGRKNSLEEYQLKFIG
                     KYGENCSIPFVEVINKDAGIGFPEYYKGGEGEAIELSDPIMQMFEKKYEEALLNGGHIE
                     FYSKDLDDFQTDQSNSLDSFELNFNIKIINNDVKLYLGANIGSGQAGRSFGRFYGLSET
                     VRETIKNLNHQNNTNVELSFVPKQIRLANVIQNYSDESYNTSFFTTSWDSENELRLEDI
                     YIRYSDGKFHFTTIDGKNELKFTMNNMLNSDSQSRVLRLLVDLSEFEYGLSHWSLFPWD
                     ILAQERVYIPEILFEDITIATAQWNLSVIREEIIHQKIFTGKKDIFNKFRKTYKIPKDI
                     ILKYADNELRLDLSIDSDLEILFKNINKYRFVSLRGIEQGESIFKDNLGNYNTEIVVPI
                     LKESNGINNTNDNVQFKNEVKKIYLPFCDWLFFKFYGPKERQEELLNNWKKFWLNLPSE
                     LFSQSNMFYMRYNDTNDHIRIRINCDSIENNFSLYLSVVQDLLPQLIESCIISDIEVSS
                     YKPEVNRYGGPHLISYAEEIFCKESILFLNNTIEFSDDERLVCATYLVLYYLNHFFKDK
                     ETRRSFLFENYTGKYKKDFKNLPIDLPIEYMKILNGVTSALDRYDFFQEMDRYLMSYMK
                     EYNRFGGTNDIYNTKFNLVGSFLHLSMNRLNGIDREFEEKVYCFAYYTLNAQQYIEWE"
     aSDomain        11666..11920
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DQL03_RS04390_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.60E-13"
                     /identifier="RREFam001.1"
                     /label="DQL03_RS04390"
                     /locus_tag="DQL03_RS04390"
                     /protein_end="219"
                     /protein_start="134"
                     /score="41.5"
                     /tool="antismash"
                     /translation="NTAAFTQGDRYVLPFTVNESEEDRNISFSKPIKLLVEKCKTRYIK
                     YEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPP"
     gene            14236..14925
                     /locus_tag="DQL03_RS04395"
                     /old_locus_tag="NCTC12047_00867"
     CDS             14236..14925
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922274.1"
                     /locus_tag="DQL03_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00867"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_111674916.1"
                     /transl_table=11
                     /translation="MLKIQNLKKSYGKRTILNNVNMNIPKGKVYALIGPNGAGKSTIMK
                     ILTGLVSKTSGSIIFEGREWSRRDLRKIGSIIEEPPLYKNLSAYDNMKVVTTMLGVSEG
                     TILPLLNKVGLGNIDKRPVKQFSLGMKQRLGIAISLINSPKLLILDEPTNGLDPIGIQE
                     LREIIESFKSEGMTIMISSHILSEVEHLADFIGFIYEGKIILEKEYDGSENLEELFNNQ
                     ILFEKRR"
     gene            14931..15680
                     /locus_tag="DQL03_RS04400"
                     /old_locus_tag="NCTC12047_00868"
     CDS             14931..15680
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984791.1"
                     /locus_tag="DQL03_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00868"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_010922275.1"
                     /transl_table=11
                     /translation="MVQIFLSNLLKIKNTSISKLILIFPIICVMLSLLFSALGGENILR
                     LTAETTVNQWGVIWINVIIAVNSGLLNKLELDSNKYSVFLSRDVDLKKVEYARVLLIAL
                     INLIISMILSLMLIVISFVLPTPSLISIGRILLTILLIWLTTLWQIPFILWLSRKINVY
                     FAMIINIISPLIIGTSFSLLNKWYLFPYDWSLKLLEPMTRMRINSIPFGAEFVPDYSQI
                     FISLFLGIAFFILLTNLFAISFKKQVK"
     gene            15683..16405
                     /locus_tag="DQL03_RS04405"
                     /old_locus_tag="NCTC12047_00869"
     CDS             15683..16405
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922276.1"
                     /locus_tag="DQL03_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00869"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_011528613.1"
                     /transl_table=11
                     /translation="MKSYLCSNFLKIKNTSYLLIHILAALLFPLLLFFYWSQRGGLQSR
                     TVLFSYFQIVGVLLPFVASIVCIQLKNLEESSGKYKYLLGYSQSNYKPFIVELVFLWLC
                     YCIVLIISITIFILLLKTIGINVSLRLLILNSLIYIIFAYVTYLINHIISYIFSTGVAL
                     GISMVGVIAAAFCETSLGDKVWFLIPWAWLLRISDTLYNQQKMAIVPLIVIFFVSCTVA
                     LLHIRIFKSWNQDCLTSS"
     gene            16597..16815
                     /locus_tag="DQL03_RS04410"
                     /old_locus_tag="NCTC12047_00870"
     CDS             16597..16815
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984785.1"
                     /locus_tag="DQL03_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00870"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_002989884.1"
                     /transl_table=11
                     /translation="MYPRIRNLREDNDFTQKFVANLLSFSHANYAKIERGEVALMADVL
                     VQFSKLYNVSIDYLLGQTDYPYRFHNK"
     misc_feature    complement(16627..16638)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     gene            complement(16886..17029)
                     /locus_tag="DQL03_RS09220"
     CDS             complement(16886..17029)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003042734.1"
                     /locus_tag="DQL03_RS09220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_021299391.1"
                     /transl_table=11
                     /translation="MGISPTGLLRWQPERSEVSLSLFVVMADREPLYFIANNYRSYHGV
                     SH"
     misc_feature    complement(17060..17076)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.88"
                     /tool="antismash"
     misc_feature    complement(17087..17102)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            17116..17337
                     /locus_tag="DQL03_RS04420"
                     /old_locus_tag="NCTC12047_00871"
     CDS             17116..17337
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003106749.1"
                     /locus_tag="DQL03_RS04420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00871"
                     /product="DUF3173 family protein"
                     /protein_id="WP_021299413.1"
                     /transl_table=11
                     /translation="MNIGFLEHTARDIIREAKRIAIKKFEEAREIDQNAVQLSKSPFDN
                     RRLGIAPKDIVEELIGILLSEESLESEN"
     gene            17340..18527
                     /locus_tag="DQL03_RS09540"
                     /pseudo=""
     CDS             17340..18527
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003106750.1"
                     /locus_tag="DQL03_RS09540"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTIKNQKKYKGVYCDKNGKIFYQADLGVDPVTGKRVQKKARKN"
     misc_feature    18565..18577
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.96"
                     /tool="antismash"
     gene            18685..19920
                     /gene="pbp3"
                     /locus_tag="DQL03_RS04430"
                     /old_locus_tag="NCTC12047_00876"
     CDS             18685..19920
                     /EC_number="3.4.16.4"
                     /codon_start=1
                     /gene="pbp3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922278.1"
                     /locus_tag="DQL03_RS04430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00876"
                     /product="D-alanyl-D-alanine carboxypeptidase PBP3"
                     /protein_id="WP_021299410.1"
                     /transl_table=11
                     /translation="MIKRWVILFFMVLTCSGFGKTVLAADFQVGAEHAIVVEADSGRVL
                     YEKDAKTPDAIASLTKLVTAYLVLDKVKSGQLQLSDQVNLSDYAFELTKDRSLSNVPFD
                     KKTYSVQDLLTATLVASSNSAAIALAEKVAGSELHFVNQMREQLSHWGITSGKILNASG
                     LPNEVLKDNRYPGSALEEENTLSAQDVAVVTMHLLEDFPEILEITKQTEVNFAGNSIKS
                     FNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENGMRVITVILNADGSDKNQNTRF
                     EQANRLLDYVARTYCRRKILKKGSLVSERSLPIQDGQVKELPVSVAEDVTIILQQGEQV
                     PKPKQFMISETSLLAPITKGEVVAYLTSPRITDQSVRYLKEPKRIPLKASQSLKKASDL
                     QLWWRDFLEKRR"
     gene            complement(20036..20998)
                     /locus_tag="DQL03_RS04435"
                     /old_locus_tag="NCTC12047_00877"
     CDS             complement(20036..20998)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407556.1"
                     /locus_tag="DQL03_RS04435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00877"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_030126694.1"
                     /transl_table=11
                     /translation="MNNRHKRRQKRKAFTLINLILLFACILGLTLIFYLYQGSNKFGLS
                     DVSQFVPKISLFHHKKTAKKETTKLKKTHFNSSKSQKKAHSKLTWTKQETPVKIPILMY
                     HAIHVMSPEETANANLIVNPDLFDQQLQKMKDEGYYFLSPEEVYRALSNNELPAKKVVW
                     LTFDDSMIDFYNVAYPILKKYDAKATNNVITGLTEMGSAANLTLKQMKEMKQFGMSFQD
                     HTVNHPDLEQASPDVQTTEMKDSKDYLDRQLNQNTIAIAYPSGRYNDTTLQIAARLNYK
                     LGVTTNEGIASAANGLLSLNRIRILPNMSPENLLQTMEP"
     gene            21329..22606
                     /locus_tag="DQL03_RS04440"
                     /old_locus_tag="NCTC12047_00878"
     CDS             21329..22606
                     /EC_number="6.3.2.-"
                     /GO_function="GO:0004326 - tetrahydrofolylpolyglutamate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008841 - dihydrofolate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995327.1"
                     /locus_tag="DQL03_RS04440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00878"
                     /product="folylpolyglutamate synthase/dihydrofolate
                     synthase family protein"
                     /protein_id="WP_111674917.1"
                     /transl_table=11
                     /translation="MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIV
                     GTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRIRP
                     LTERLVQETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMVVV
                     CPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWE
                     WQEQFQMVENASGYRFTSPLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTSD
                     HIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAVLKNNYNDKKLHILFGAIDTK
                     PIADMLVALEQIGDLQVTSFHYPNAYPLEKYPEHFGRVADFKDFLALRKHAKADDFFVI
                     TGSLYFISEIRRYWKKHIEKSVLLTH"
     gene            22659..23225
                     /gene="folE"
                     /locus_tag="DQL03_RS04445"
                     /old_locus_tag="NCTC12047_00879"
     CDS             22659..23225
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GTP_cyclohydroI"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989871.1"
                     /locus_tag="DQL03_RS04445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00879"
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="WP_032460184.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 9.4e-77,
                     bitscore: 253.1, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFLG
                     LGKDPKEEFTAVFKEHHEDVVIVKDISFYSICEHHLVPFYGKAHIAYLPSDGRVTGLSK
                     LARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHMCMTMRGIKKPGSKTI
                     TTTARGLYKESRAERQEVISLMTKD"
     gene            23234..24025
                     /gene="folP"
                     /locus_tag="DQL03_RS04450"
                     /old_locus_tag="NCTC12047_00880"
     CDS             23234..24025
                     /EC_number="2.5.1.15"
                     /GO_function="GO:0004156 - dihydropteroate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="folP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528620.1"
                     /locus_tag="DQL03_RS04450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00880"
                     /product="dihydropteroate synthase"
                     /protein_id="WP_011528620.1"
                     /transl_table=11
                     /translation="MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMI
                     ADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARAAL
                     EAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRAQAA
                     LDAGVPKNNIWIDPGFGFAKSVQQNMELLKGLDRVCQLGYPVLFGISRKRVVDALLGGN
                     TKAKERDGATAALSAYALGKGCQIVRVHDVKANQDIVAVLS"
ORIGIN
        1 tctacgaatt aattaaataa gatgcttatg acagtaaaaa gggctggaac attgttccag
       61 ctcttttgtg atgattagaa aatggtctta tttaccaaga caaaattggc taaagagttg
      121 ggtaatgagt tcatcaggag cagcatcccc tgtgatttct ccgagaattt cccaagttct
      181 ggttaaatca acctgtagta aatcaactgg catgccaagc gccaaaccgt cattgacagc
      241 ttctaaactc tggactgcct tttcaatcaa agaaatgtgg cgggcatttg acaggtaagt
      301 ggcatcttgc tctaccaaac cagcgttgtc aaagaaaagc tggttgatac gatcttcgat
      361 tagattaatg ttctggttgg ttaaaacgga aatgggaatg tagtcatctg gtaattgctc
      421 taattcaatc ttctgttcca aatccgtttt attcaacaat ataatacggt tactgtcctg
      481 actgagattt aacaaagccc ggtcttggtc agtcagtttt tcagaagcat tcagcacaag
      541 aagaacaagg tcagcttctt gaagagcttt tttagaccgt tcaactccga tttgttcgac
      601 cagatcatct gtctcacgaa taccggccgt atcgacaagt tttagaggaa ctcccttgat
      661 attaacgtat tcttcaatga catctcgggt ggttcctgca atatcagtca caatagcctt
      721 gtcttctcgc aacaaattat taagtaagct tgacttaccg acgtttggac gaccaataat
      781 agctgttgat aagccctcac gcagaatttt accgcgttta gctgttcgaa ggagactttc
      841 caaaaggctt tggaattctt gtgttttctc acgtagcaga gcagtggtca tttcttccac
      901 atcgtcgtat tcagggtagt caatattgac ttcgacttga gctaaggtgt tgagaatttc
      961 ctgacgggtg tcattgataa gctgggaaag ggagccatcc agttgcttga ctgcaatcgt
     1021 catagccttg tctgttttgg cacgaataat gtccatgaca gcctcagctt gagtcaaatc
     1081 aactcgccca tttaagaagg cacgtttggt gaattcgcca ggctctgcca ttctagcgcc
     1141 ttggcgaatc aatagttgca agatttcatt tgtcacagca ataccaccgt gcgtattgat
     1201 ttcaaccaca ttttcacggg taaaggtttt gggggctagc atgactgaca ccataacttc
     1261 atcgataata gttcctgtct taggattaat gatatggcca tagttaatgg tgtgtgaggc
     1321 gacttgctct aagttctttc ccttaaaaac agattgtgca atggcaagcg catctgtccc
     1381 ggatagacga acaatgccaa tagctccttc accaagaggg gttgaaatgg cggtaattgt
     1441 atcaaattct ttagttatac tcatgccctc tattttaaat caagtcctag tagaaagcaa
     1501 ggtattattt tgtatagaaa ataggactag caccattttg agtttagcta atactaaaaa
     1561 aaataaatgt aaaaaaatca tttttttaat aatttttatt gacaatagta ttataaaaga
     1621 atataatgat ataggttttg ataaaaaact gacctaagac agcaggggag catgctcata
     1681 atattcctgc cgaggcacaa aacgtgatta aagaaaataa cgtatttgta ctttcgtgtc
     1741 taggtttagg tgcgattttt ttgtacctag cccaaaaata aaaacggagg taaaactaat
     1801 gagtgaagca attattgcta aaaaagctga acaagtcgaa cttattgctg agaaaatgaa
     1861 agcagcagca agtatcgttg ttgttgattc acgtggtctt acagttgatc aagatactgt
     1921 tcttcgtcgt tcacttcgtg aaagtggcgt tgagttcaaa gttatcaaaa actcaatttt
     1981 gactcgtgca gctgaaaaag caggtcttga tgagttgaaa gatgtattcg taggaccatc
     2041 tgcagtagca ttttctaacg aagatgttat cgcaccagct aaagttatca acgactttac
     2101 taaaactgct gacgcacttg aaatcaaagg tggtgcaatc gaaggcgctg tttcttcaaa
     2161 agaagaaatc caagcacttg caacattgcc aaaccgcgaa ggaatgcttt ccatgcttct
     2221 ttctgtactt caagctccag tccgcaacgt tgcatacgct gtcaaagctg ttgcagaaaa
     2281 caaagaaggc gctgcttaag acgtctcaga gtagcttaag gctacgctta acattttaaa
     2341 ttaattattt ggaggaaatc acaatggcat tgaacattga aaacattatt gctgaaatta
     2401 aagaagcttc aatccttgag cttaacgatc ttgtaaaagc tatcgaagaa gaatttggtg
     2461 taactgcagc tgctcctgta gctgctgcag ctgctggtgg tgctgaagaa gctgctaaag
     2521 attcattcga cgttgaattg acatctgctg gcgacaaaaa agttggcgtt atcaaagctg
     2581 ttcgtgaaat cacaggtctt ggtcttaaag aagctaaagg tcttgttgat ggagcacctg
     2641 ctaacgttaa agaaggcgtt gctgctgcag aagctgaaga aatcaaagct aaacttgaag
     2701 aagctggagc aacaatcact cttaaataag aagcagatag caatttgaga gcgaaatccc
     2761 gatttatcag ttttttagag cttatagcga tttgaagaaa ctgataaaat gatttggttt
     2821 cttgccaaaa atcctgccaa aaattttttg gcaggatttt tattttctat aaaaattaag
     2881 ctgagtagag tggctattct atttatatgt gtctagtaat aattttttta tgtgaacgag
     2941 aacattttaa taagtgttct cgttttttta tgttcaggag gaaaatcatg caaatgaatg
     3001 aacagtcatc acgacaaatg gtgattgcca tctatctcat ttattccaac tcaaaatgat
     3061 agtactcctt ggctgttcca agtcgaaatt gttagtgatt aagaaaatct acgagactat
     3121 ggtttgatcg atgaaggcca gcagtctccc agtgaaaaag ggcgtttggc taataagatt
     3181 tatttaggaa agttggaaca tgattccacc ccagtcttaa gttcagacgg gggtagtcta
     3241 aaaaaacacg ggaccagtct caaaaacaga caagccccgt gttaaattca gcccctagtg
     3301 agactgaaaa gagtgaaact gaaggtagtg aaactaaaga gagtaattta gtcattgagg
     3361 acgaggagga aagaaaggag tgcactagtg tgaaaaagac tgagggtcac tttacccgtc
     3421 aagttgatca ggtcaccaaa tatgacaaag attatatttg gagtttggtt cattcccaat
     3481 tacgtgaagg tggtttatca caagctgcta gtgacttagt catgagctat tttgaagaac
     3541 gctatgctta tgcgctggaa cacatacggt tcgcaagaac agctgaagct attgcggaat
     3601 atgtctttaa tggtgtctta tccgaatgga ccaagcaact aaggtgacaa gaagcgaagt
     3661 gaggtgagta agatgttttg gtggctatta ttaggtgttt ggggtctaag gacaatttgg
     3721 ttgattattg aagttatcac tgcaccagaa atggaagatt atagttgagt aaggacgtta
     3781 cataagcagt aaggtccttt tattttgtca gaaaggaatg agagatatga agtttttaga
     3841 tttgtttgca ggaattggag gctttcgatt gggtttaatt aatcagtgcc atgagtgtat
     3901 tggcttttgt gagattgata agtttgcgag gcaatcttac aaagccatct atgagaccga
     3961 aggagaaata gaatttcatg acattagaca agtcacagac caagacttta gacaacttag
     4021 agggcaagtg gatatcatct gcggtggttt ttcccttgtc aagcattttc actcgcaggc
     4081 agacgactgg gatttgaggg cactaggaga actctcttct ttgagattac tcgagcgact
     4141 catacagaca aagatcatat tcataatcac atcttaatca acgccattga ctgtaattca
     4201 gataaaaagt tgatatggaa ttatgccttg gaacgaaacc ttcgtatgat ttcagaccgc
     4261 atttctaaaa tggctggggc gaaaattatt gaaaagcatt tctcttaccg tgactatcaa
     4321 aaatatagag cgactagcca taagtttgaa ctaaagcaac gtctttattt tttgatgcag
     4381 cagtcaaagt tctttgatga ttttttagaa aaagcagagt aattacatgt tcatattgat
     4441 tttaggcaga agcatagcag attcatgatg acggatcgag taatgaaaaa accaattcga
     4501 ggtcgtcaac tcagtaaacg agatttatat gatgaagaat tttttcgtac acattttgcc
     4561 aagatagaaa ttgaaagtcg attaaaattt ttgtttaacc gtgccaattc attagaggag
     4621 ctactattaa aagcaaaaga agtgaatcta accattgact taaaacaaaa aatgtaactt
     4681 ttatcctaga agaagatact caaaagataa gtttaggtca taaaaaaata agcgataaga
     4741 aattatatga tgtcaatttt ttcaagatta ctttaaaaat aaggaagtcg gtgtttcaga
     4801 tcgattagaa agtctacaga aacagtacat gcttttcaag aagaatgaga taaagaggag
     4861 gtatccactg aagagagtaa ggaagtcttc aagaaataca aggggcaacg agatgccatc
     4921 catgagtttg aagttgaact tgtggaacat caaattgaga ggctaattgc tgaggacatt
     4981 tatatcaagg tgtcttttgg tgtaaagcag agtggtctta ttttcattcc taactatcaa
     5041 ttggatatta ggaaagaaga aaatcataaa aaatataaag tctatattcg tgagaccgca
     5101 caattcttca tttacaacaa ggaggcgtct aaacttaatc gctatgtgcg agggcgtgag
     5161 ctcatttacc agttaaccaa tgatagcaag agtattccaa aaagaagacg accaaaacca
     5221 ttgatacact taagaaaaag attgaagaaa taagtctcct cattgagtta gatacggaga
     5281 ataagcctta tcaagatatt aaagatgaca ttgttaaaga tatggatcaa ttagatttga
     5341 ccattacaga gttgcaggac catattgctc atctcaataa ggttgcggag gtcttgctta
     5401 atctgaacaa caacgatata gagaaccgcc gtttggccag atatgactat gccaagatga
     5461 acttgactgc agctataaaa atagaagaag ttgagaaaga gattgaaact tctcaaaatg
     5521 aacttaatat atccatagat gagtatgaat atctagtaag aaggttggaa aagtttggag
     5581 agatcttgag tgatagcaaa attatcgata cttctcgaaa tgaaatacaa tgggagtaat
     5641 tatgatataa tttgggtggt agcaattttt atatcagata ttaaaatcta gttgatgttt
     5701 cgtaaataac tatattaaag aaatgattcc tgccgcttac attaagaata gtttatttgt
     5761 aagtatttca ttatttaaaa ggggtaataa tgtataagat tttagccata gatgatgata
     5821 aagaaattct gaagcttatg aagactgctt tggagattga aaattatcat gttataacct
     5881 gtcaagagat agaattacca atagtttttg atgattttaa aggatatgat ttgatcttat
     5941 tggatatcat gatgcctaat ataagtggaa ctgagttttg ttataaaatt cgggaagaag
     6001 ttcattctcc aattattttt gttagcgctt tagatggcga taatgaaatt gtccaagctt
     6061 taaatatagg gggagacgat tttattgtga aaccatttag cttaaaacaa ttcgtagcta
     6121 aagttaactc tcatttgaag agagaagaga gagcaaagat aaagaatgag gctgaggaga
     6181 gagtgaagcg cagttttcca cctatagaaa tctatctaga ggaacgtatg ttatatattg
     6241 ataaacagcc gttattcctg acttatagag agtacgaaat tttagaatta ctgtcacgtc
     6301 atccgtataa agttttcaca aaagaagaga tatatgaaca agtatatagc gatgaagctt
     6361 cagcattgtt tcattctatt tcagaatata tctatcagat tagaatgaaa ttttcaagtt
     6421 ttggaattaa tccaataaaa actattcgcg ggattggtta taaatgggat gtttaaaaaa
     6481 tattcaataa aaaatcgtgt ttggcgcgcc gtcgttgaaa ttgtctttgg agtttgtatc
     6541 actgttttaa tgattgcgat aatatcgctt tctttttcaa agttaaatat agtgacatct
     6601 cataatgtgg gagaagaatt ttatattaaa gataaacagt caatcaaaca gttgaacaat
     6661 tatatgaaga cattgggatt agattatgtt gtttttgata gaaaaacaga taaagctatg
     6721 gaaggaaaat atttatctaa agaattttct ttatttaacg aagttgcaga agaaaaaaat
     6781 aatctgactt ttaattctgt acattatgat ttatatacta atatcaatta taatattgtt
     6841 ataagatata atgagatacc ggagttttct aaccattacc ttagaaatgt ttcatataac
     6901 atgttgacat tttatattct gggaatagga acgagtatca gcattgtagt tgctttaaca
     6961 cggtttgtaa aagaaatttc tttgaatttc aaggaaatca agaagttagc aaataaaatg
     7021 gggatagaag tcctttctga aaatgaaaat tattctaaaa taatcgagtt tgatgatata
     7081 cttagaactt tacatattaa aggtgataat ttgaaaagtt tgattgagcg agaaatattg
     7141 gaaaagcaag atctatcctt tcaaattgca gcactttcgc atgatataaa aacaccttta
     7201 acggttttga aaggaaatct tgagttatta gaattgacta ctttaaataa aaatcaggaa
     7261 ggttatattg tatctatgaa caatagtatt tctgtttttg aaggctattt caattcttta
     7321 atatcttata cacgcatgct ttcagaggat agatcagtga aactaatttt agttgaggag
     7381 ctattaagtg agttacattt tgaagtcgat gacttattga atatcaataa tattgaattt
     7441 tctatttgta atagacttat tatcacttct ttttatggag atgaggaaaa tctgataaga
     7501 gctctttcta accttttagt taatgcaata agatttatgc ccgtattaga taaaaaaatc
     7561 gaagttatac tgtctgagtc aggagagcaa attcattttg aaatatggaa taatggtgag
     7621 cgtttcagtg atagtacact gaaaaaggga gataaattat tttacacgga agattatagc
     7681 agaggtaaca aacattatgg aatcggtttg gcatttgtta aaggcgttgc tatcaaacac
     7741 ggtgggaatc ttcaattgaa taatccagct agaggaggtg ctagcgccat aatctcgata
     7801 aaaaagaaaa tttaatagat ttgattgaaa ctggagtatt tcaggcaaaa aatcgtaaat
     7861 tttggtgatt tttggctaaa atactttttt tctgaacaaa ttctgaactt ggggtgtcat
     7921 aataatcatg taaatatatc ggatgcaaaa acgtaagaga ggaactagaa aatgaataac
     7981 acaattaaag actttgatct cgatttgaaa acaaataaaa aagacactgc tacaccttat
     8041 gttggtagcc gttacctatg tacccctggt tcttgttgga aattagtttg ctttacaaca
     8101 actgttaaat aataaagtta tcattatcat caacattata atttcaaata atttgatata
     8161 tttataaatt taggggagta gactgatttt agtttgctcc tttattagta gataaggaag
     8221 ttatacatga ttaaagctca gctaaagaat ctaataaaaa caattcatct cgtaaaagag
     8281 gctggtttct ccctactggt gttctcaatt gctattagct tatttcaagg gattttaccc
     8341 atttttagta tgctactagt tcaaaaaatg ttaaacatta taacgactga tataaaaaat
     8401 tttcacacat tgatgattgc ttttatctca tatattgctt taacattatt gacaattata
     8461 ataggagaag ttgatagtta tattgatact aaattacaga tacttcttca ctataagatg
     8521 aaccatttag ttatgcagaa aactgtaaag ttaacattgg ctgaatttga gacaccagaa
     8581 atctatgatg atatcactcg catacaaaat caaatatctt ataaaccttt tcaaatatat
     8641 aagtcaatta tttctgtatt atcttcgtta gtatcattaa tttcctcatt tgttatttta
     8701 ttaaattgga agatatcaat ttttccactt ttacttatcc ttcctatcgt ttctatatat
     8761 atctacttga aaattggtaa aaatgaattt gagatactat ataaaaggag tagcgatgag
     8821 agagcaaatt ggtatattag tcacctttta acacatgatt ttgctgtcaa ggagttgagg
     8881 ttaggtacgt tagaaagtta ttttctaaaa aaatatgata aaaataatca attatttatt
     8941 aatcaggaaa atagtataaa tagatctaaa atgaaatacg gtatagtatt aggtgtattg
     9001 gagattgcta tacaatctat tattatgttc cttgcagtta gagaagcatt tctaggaata
     9061 ttattagttg gaaatgtaac tacttttata aggtctttat ctacaatgca aacaagtaca
     9121 caaaatatag taaataatat ctattctttc tataatggtt cattgtacat ggagttattg
     9181 tatgatttta cgcttgatga gttagtacat aaccctataa tcgaaagtac ggttgataca
     9241 attcagtcag ttgaatttga aagagtttct ttttcatata atggtaagga taatgtaata
     9301 aacgatataa gtttttcaat taaagcagga gagaggttag caattgttgg tgaaaatggt
     9361 tctggaaaaa gtacgatttt caaattagcc tgcggtcttt acgataatta tgaaggcaat
     9421 atatatataa atggtattaa tcttcgttca atacagaaaa agtcatacta caagagaata
     9481 tccgcattgt tccaagattt tttaaagtat gaattgacac tgcgtgaaaa tgttggattg
     9541 ggtgaattat caaagttata tagtgatgag gatttaataa gtgcactgaa gtatacagga
     9601 gttgattcga tattttactt taatcaggaa aaattaaatc agatagatct ggaacagcaa
     9661 ttagggaatt ggtttgagga tgggagacag ttatctggtg gacagtggca aaaaattgca
     9721 ttatcaagag tatatctcaa agaagcggat tgctatttgc tagatgagcc tagttctgcg
     9781 ttagatcctg agtctgaaac aaaaattttt aaaacatttt ttgaattatc gcaaaataaa
     9841 attggtattt ttattacgca taagccaagc attactcaat ctgtgaataa aattttgtat
     9901 ctagataatg gatgtatatc tgaaacagga agtttcgctg atttaaatat taaaggaatg
     9961 aagtttaaaa acttattaga taaagaaatt ggagccacat atgacacctc aaattaaaca
    10021 gatagtagat tacattgcag atagttttat aaattatgaa cagatagtag ctgaaagtga
    10081 gaataaagta ctaattaata ttgaatctaa atatagaaat accttttttg ataaatctct
    10141 gagtcatggt gtgccatcat taatcttaat gtatagttca ctatataaag tgacaaaaga
    10201 tgagagatat ctaacattct ccaacatata cgttgagaaa ttagtagaca taatctctag
    10261 agatggtata gaatctccgt ctctctatgc tggcactgca ggtattgcat tagctattaa
    10321 agaagcgagt atatctggaa agtattatcc gaaattatta tcatccttaa attgtcttct
    10381 aaaagaacaa attaaagaca aattggtagt aagtttttct aatattgaga aaggaattat
    10441 tgagccatat gattatgata tggttaacgg atttagtgga ataactaatt acttactcct
    10501 tgaacaagaa tttttttctg tagagttaaa tcaaattgga aattatcttt tgaaatatat
    10561 tgagacaatt ttaaataagg taactaattg ttctgaagat agagaagctg aatttgatct
    10621 aggaattgca catggaatta ctggtcctat gctaatccta gcaaaattaa aatcagaaaa
    10681 aattttgagt gtagaagtag gagatatact gaataaagct ataaatttaa tgtttttatt
    10741 tagaagggat gacaaactat ggcctggaaa aatttatact agtaatattt tggatcttga
    10801 tttaaattat cttcctacta gaatggcatg gtgttacggt acgcctggaa ctgcagttgc
    10861 cctttttaaa atgtgtcaat tgatagattt aaattttatt gacgatatta atgaaagttt
    10921 aattgctcag atgagaagtt cagacaaaaa tgtctattct cttacaatgt gccatggttt
    10981 ggcaggagta acttttatat atgacttgat tggtaaaaat tattcaagtg agaggctaac
    11041 tcgctttgca gaagagcttc gccaacaaat aattacatcg ttttcaacta caaaagtatt
    11101 tgggtatact gacagagaaa aatttggaga aatagaagtt gaactggagt caatagggat
    11161 attgcaaggg gtatcaggga tagtgttatt cttattaaat ccttacagtg acgaggagct
    11221 attgtggcaa agaatattta tttaatttga aaaggagaac aaaatgtata aggtatttcc
    11281 aactggtatg attcgtattc cattgcaaaa acaagaattt tataataaag actatgaaga
    11341 tttaataaat gataaagttt ttatggaaca acttttagtt gctagtccca gtctttatga
    11401 tagtgtaata gattttgata aatgtaatga aaagaaaaag caaaatgtaa aagtctcatt
    11461 aaatagttat tctaaaagag cagcgtttag aactactcca tttggtatct ttactgctat
    11521 taatacagtt gatttgacaa agggaaccac ttctaatgta caaaaggtta gttttattaa
    11581 aaaagcagtc ccagattatt catggatata ttctctagta aaatcgtatg aaataagtaa
    11641 ccttgaaaaa ctttcattaa aaataaatac agcggcgttt actcaaggtg acagatatgt
    11701 actaccattt acagtgaatg aatcagagga agatagaaac ataagttttt caaaaccaat
    11761 taagttactt gtagaaaaat gtaaaactcg atatataaaa tatgaagagt taatagatgt
    11821 atttaaaaat aattatccag atatagtgtc agacatgcta gagtcatata tacacgactt
    11881 agttacaaat gattttttaa tttcagattt aagaccacca atttgtaata tcaattcctt
    11941 agattatcta ctatctaaat tagaagaagg aacactatgt actgacttaa ctactttaaa
    12001 gaagatgatt gaagattaca acgatttaaa tattggggaa ggtagagact tacttttgca
    12061 gatttttgat aaaatggaaa gtatttataa atatgataac ggtggaaatt acttaaaagt
    12121 tgattcatta gcagagtatg aaggcgattt taacattcta tctgaaacgg ctcgggaaag
    12181 tatagaacga ctcgcagaga tgtttgtaaa attaaataca aatgtaaaga gaagaggggg
    12241 gaggaaaaat tcacttgaag agtatcagtt gaaatttatt ggcaaatatg gagaaaactg
    12301 ctcaattccc tttgttgaag taataaataa agatgcaggc ataggttttc ctgaatatta
    12361 caaaggagga gaaggtgaag caatagagtt aagcgatcca ataatgcaaa tgtttgaaaa
    12421 gaaatatgag gaagctctat taaatggagg gcatatcgaa ttttattcaa aagatttaga
    12481 tgattttcaa acagatcaaa gcaatagttt agattcgttt gaattaaatt ttaatataaa
    12541 aataataaat aatgatgtga agttatattt aggagctaat atcggttctg gacaagcagg
    12601 tagaagcttt ggaagattct atggattaag cgaaacagta agagaaacaa ttaagaattt
    12661 aaaccatcaa aataatacga atgtagagtt gtcatttgtt cctaaacaga taagacttgc
    12721 gaatgtaatt caaaattata gtgatgagtc ttataatact tcatttttta ccacatcatg
    12781 ggattcagag aacgaactgc gattggagga tatttatata agatatagtg atggtaagtt
    12841 tcattttaca actatcgatg ggaaaaatga gttgaaattt accatgaata atatgctaaa
    12901 ttccgatagc caaagcaggg ttttgagatt gttggttgat ttatctgagt ttgagtacgg
    12961 tttatcgcat tggtcattat ttccttggga tattttggct caggaaagag tatatattcc
    13021 tgaaatttta tttgaagaca ttacgattgc cactgctcag tggaatttat cagtaattag
    13081 agaagagatt atacatcaaa aaatatttac tggtaaaaaa gatatattca ataagtttag
    13141 aaagacttat aagataccta aagatattat tttgaaatat gcagataatg aattgaggtt
    13201 agatttatct atagatagtg atttagagat tttatttaaa aacattaata aatataggtt
    13261 tgtttctttg agaggaattg agcagggaga gtctattttt aaggataatt tagggaacta
    13321 caatacagag atagtagttc caattcttaa ggaatctaat ggaataaaca atacaaacga
    13381 taatgttcaa tttaaaaatg aagttaagaa aatatattta ccattttgtg actggctatt
    13441 tttcaaattt tatggtccaa aagagcgaca agaagaatta ctaaataact ggaaaaaatt
    13501 ttggctaaac ctgccatcag aactgtttag ccaaagtaac atgttttata tgagatataa
    13561 tgataccaat gatcatataa gaattcggat aaattgtgat tcgattgaaa ataacttttc
    13621 tttgtatttg tcagtagttc aagatctatt acctcaactg attgagagtt gtattatctc
    13681 tgacatagaa gtgagtagct ataaaccaga agtaaataga tatggaggac ctcatttaat
    13741 aagttatgca gaggaaattt tttgtaaaga atctatctta tttcttaata atacaataga
    13801 attttcagat gatgaaagat tagtttgtgc tacttacttg gttctatatt atctaaatca
    13861 ctttttcaaa gataaagaaa caaggcgctc tttcttattt gagaattata ccggaaagta
    13921 taagaaagat ttcaaaaatt tgccaattga tttacctatt gagtatatga agattttgaa
    13981 tggagtcacc tcagctcttg atagatatga ttttttccaa gaaatggata gatatctcat
    14041 gtcttatatg aaagagtata atcgatttgg tggtacaaat gatatctata atactaaatt
    14101 caatttagta ggaagttttt tacatctatc aatgaatcga ttaaacggga ttgatagaga
    14161 gtttgaagag aaagtgtatt gttttgctta ctatacacta aacgctcagc aatatataga
    14221 atgggagtaa ctaatatgtt gaaaatacaa aatctaaaaa aatcttatgg taagagaacc
    14281 atattgaata atgtcaatat gaatattcct aagggaaaag tgtatgcttt aatcggtcca
    14341 aatggtgctg gaaaatcaac tattatgaaa attttgacag gcttagttag taagacaagt
    14401 ggttctatta tttttgaagg tagagaatgg tcacgtcggg atctgcgaaa aatcgggagt
    14461 attattgaag aaccaccact ttataaaaat ttgagtgctt acgataatat gaaggtagtt
    14521 acaacaatgc ttggtgtttc agaaggcact atacttccat tattaaataa agttggtcta
    14581 ggaaatattg acaagagacc agtaaaacaa ttttctcttg gaatgaagca acggttaggt
    14641 atagctatct ctttaataaa ttcacctaaa ctacttatat tagacgaacc tactaatggc
    14701 ttggacccaa ttggaattca agaattaagg gaaattatag agtcatttaa atcagaagga
    14761 atgacaatta tgatttcaag ccatatactg tcagaagttg aacatctagc tgattttatt
    14821 ggatttatct atgaaggaaa gattattctg gaaaaagaat atgacggctc tgagaatctt
    14881 gaagagttat tcaataatca aattttattt gaaaagagga ggtaggggct atggtacaaa
    14941 tttttttatc aaatttatta aaaataaaaa atacgagtat tagcaagttg attcttattt
    15001 tccctattat ttgtgtgatg ttatctttat tgttttcagc attaggtggt gaaaatatcc
    15061 tacgtttaac tgcggaaaca acagtaaatc agtggggagt tatttggatt aatgttatta
    15121 ttgctgtaaa ttctggtttg ttaaataaat tagaattaga ttctaataag tattctgttt
    15181 ttttatcaag ggatgttgat ttaaaaaagg tagaatatgc cagagttcta ttgatagctc
    15241 ttataaatct aataattagt atgattttaa gcttaatgct tattgtaatt agttttgtcc
    15301 tacctactcc aagtcttatt agtataggta ggatactatt aactatcttg ttaatttggt
    15361 tgactacact atggcaaatc ccgtttattt tatggctatc aagaaaaatt aatgtgtatt
    15421 ttgctatgat tattaatatt atatctccac taattattgg tacaagtttt tctctcttaa
    15481 ataaatggta tttgttccct tatgattggt cgttgaagtt gcttgagcca atgacaagaa
    15541 tgagaataaa tagtatacct tttggagcgg agtttgttcc agactactca cagattttta
    15601 tatcattgtt cctaggaatt gcttttttca tcttactgac caatctattt gctatctctt
    15661 tcaaaaaaca ggtgaaatag tcatgaaatc atatttatgt tctaattttt taaaaatcaa
    15721 aaatacttca tatttactaa tacatatttt agctgcacta ttatttccct tacttctatt
    15781 tttctattgg agtcaacgtg gaggtttaca aagcaggact gtattattct cctactttca
    15841 aatagtaggt gtacttcttc cttttgttgc aagtattgtg tgcattcaac taaaaaattt
    15901 agaagaatca tctggaaaat ataaatattt attgggttac tcacagtcga attataagcc
    15961 atttattgta gaattagtat ttctatggtt atgctattgt atagtattaa ttatttcaat
    16021 tactatattt attcttttat tgaaaactat tggtataaat gtatctctca gactacttat
    16081 tttgaatagt ttaatttata tcatttttgc ctatgtaacc tatctgatca atcatattat
    16141 tagctatata tttagtacag gtgtggcatt aggtatttca atggtaggtg ttattgctgc
    16201 agcattttgt gaaacgagcc ttggtgataa ggtatggttt cttattccat gggcatggct
    16261 tttaagaata tcagatactc tatataacca acagaaaatg gcaattgttc cacttattgt
    16321 tatatttttt gtttcatgca cagtagcttt acttcatata cgaatattta aaagttggaa
    16381 tcaagactgt ttgacaagta gttaaataca tctattttgt ttacctagca ataaatatga
    16441 ttttttaagt tataaatact atctaacttg tttaactaaa aaatgactat aaaatttcaa
    16501 tggattacta gcttatattt aatagtcttg tccaaatagg acaattaaac attttttaat
    16561 caaatctcct ttatactgat attaggagaa tgttagatgt atccgcgtat taggaatttg
    16621 agagaagata acgatttcac tcaaaagttt gttgcaaatt tactttcctt ctctcatgca
    16681 aattatgcaa aaattgagag aggagaggtt gccttaatgg cagatgttct tgtgcagttt
    16741 tctaaactct ataacgtcag tattgattat ttattagggc aaacagatta tccgtatcgt
    16801 tttcataata aataaaagtc tcgccttgat ttgttcattg acaactgaat aaaccgaggt
    16861 gggactttct tgtttgtcga gcaatttagt gagatacgcc gtgataggag cgataattat
    16921 tagctataaa atagagtggt tctctatctg ccatgaccac aaatagggac aatgatactt
    16981 ctgaacgttc aggctgccag cgtaaaaggc cagtgggtga gattcccatg agtgatttaa
    17041 ccagtcatac ccacggaggt tgcaattttt ttgaaaggag tggaggtgtg aaaatagtaa
    17101 catataaaaa gcttgatgaa tattggtttt ctcgaacata ctgcaagaga tattattaga
    17161 gaagcaaaaa gaatagctat aaaaaagttt gaagaagctc gcgaaattga ccaaaatgcg
    17221 gtacaattaa gtaaatcgcc ctttgacaat agaagacttg gtattgctcc taaagatatt
    17281 gtagaagagt taataggtat tctactctct gaagaaagtt tagaaagtga gaattaaaga
    17341 tgactataaa aaatcaaaaa aagtacaaag gtgtttattg tgataagaat ggtaagatat
    17401 tttatcaagc tgatcttggt gtagatccag taacaggtaa acgagttcaa aagaaagcca
    17461 gaaagaatta gtatggagag ccatttggca caatgaaaga agcgtatgat gaactggttc
    17521 ggattaggta tgggtttagt aataatctta gtattgaaaa tgacaatata tcgtttgaaa
    17581 actatatgaa tactatttac ctaagagcat ataagcaaaa ggttcaggct gtaacttatg
    17641 aaatagcctt accacatcat aagttattta ttcagtattt tggttctaaa cttttaaagg
    17701 gaataacagc ttgagattgt gaatctttta gtttacatat tattgaaaat tatgcaaaga
    17761 atttatggtc gcgattcaaa gcttgcatgg ggtatgctga aaggttagac tatatttcaa
    17821 aagtgccgtg taaggctttg gataatccta aagggaaaca tcccgatact ccattttgga
    17881 cttatattga gtttcagaat tttataaaat cgtttgattt gcaagattat gaagagctac
    17941 aaagatttac aactatttgg ctatattata tgacaggtgt tcgtgtaagt gaaggtttat
    18001 cattatgatg ggaagatatc gatttcgaac aaaaattttt gaaagttcat acaaccttgg
    18061 aaaaggatga aaatggaaat tggtatcgta aagatcaaac aaaaacgcca gcaggagaac
    18121 gtcttattga gttagatgat gtgacaatag tagtattgga aaattggaga agaaatcaag
    18181 tagtcaatac tgacacagat ttcattattt cacggtttgg tgaaccattt tgtaaatcaa
    18241 cgatttgtcg agttattaag cacaaagctc aagaagtagg agtaccagtg ataacgggaa
    18301 aagtcttgcg acatagtcat gcttcctatc ttattaatgt tttgaaaaaa gacattctgt
    18361 acgttgcaaa gtgtatggga catgctgata agtctacaac tttgaataca tatagtcact
    18421 ggtttaatgc attagataaa acagtatctg aagaaataac ccaaaatgta ataagttcag
    18481 gattagattc cattttatac caaaattcct gccaaacaac taattgatat aacgaagctt
    18541 attatatcgc ccatataaca ggatgtgtta ttgtcacagg gtacttgctt tatgagcttg
    18601 tttaagctac taaaggtgtg tgccactata cttccttcca aatttctgag aatttttgtt
    18661 ataatagtaa ctatgaaaga tataatgata aaaaggtggg ttatcctttt ttttatggta
    18721 ttaacttgtt cagggtttgg taaaacagtt ctcgcagctg attttcaagt gggagcagaa
    18781 catgcgattg tcgtagaggc agactctggg agagttctgt atgagaaaga cgctaagacg
    18841 ccagatgcta ttgcctcttt gaccaaattg gtgacggctt atctggtttt agataaggtt
    18901 aaatcaggcc agctgcaatt atcagatcaa gttaatctct cagattatgc ctttgagtta
    18961 acaaaagata ggtctttaag taatgtacct tttgacaaaa aaacttattc agttcaagac
    19021 ctgttgacag ctactttggt agcaagctca aatagcgctg ctattgcgtt agccgaaaaa
    19081 gtggcgggtt cagagcttca ttttgtaaat caaatgagag aacagctatc tcattggggg
    19141 attacttctg gtaaaatcct caacgcctca ggtctgccaa atgaggtgtt aaaggataat
    19201 cgttatcctg gttctgcgtt ggaagaagaa aataccttga gtgctcaaga tgttgcagtt
    19261 gtgacgatgc atttgttaga agattttcct gagattttag agatcaccaa acaaacagaa
    19321 gttaattttg ctggcaattc tattaaaagt tttaatcaac tcttaccagg tatggctaag
    19381 ggtagagcag gagtggatgg tttaaagact gggacaacag acttggcagg tcattgtctt
    19441 gtggtaactt ctattgaaaa tggtatgcga gtgattaccg ttattctaaa tgccgatgga
    19501 tctgataaaa accaaaacac gcggtttgag caagcaaatc gtttgttgga ctatgtggct
    19561 agaacttatt gtcgtcgtaa gattcttaaa aaaggaagtc ttgtctcgga gcggtcgctc
    19621 cctattcaag atggccaagt aaaagaacta ccggtatctg ttgccgaaga tgtaaccatc
    19681 attttgcaac agggtgaaca agttcccaaa cctaaacaat ttatgatatc agagacttct
    19741 ttactagcac cgattactaa aggtgaagtg gttgcttatt tgacgtctcc aagaataaca
    19801 gatcagtcag tgaggtattt aaaggaacct aagcgtattc ctcttaaagc tagccaatct
    19861 cttaaaaaag cctctgactt acagctgtgg tggcgagatt ttcttgaaaa aagacgttaa
    19921 agataagaat aaaataattt taaaacaatc aaaaaagaca gttatgaaag aattttttca
    19981 taactgtctt tttagtttac agtgagtatg atttggaatg ataaaaaaat tgatgttatg
    20041 gttccattgt ttgtaaaaga ttttccggac tcatgtttgg gaggatacga atccggttaa
    20101 gagaaagaag tccattagcc gcgctagcta ttccttcgtt agtggtaaca cctaatttat
    20161 agttaagtct agctgcaatt tgtaaggtag tgtcattata tctaccagat ggataagcaa
    20221 tggcaatagt gttttggttt aattgcctat caagatagtc ctttgaatct ttcatttcag
    20281 ttgtttgaac atcaggacta gcctgctcta gatcaggatg attcactgta tgatcttgga
    20341 aagacatacc gaattgtttc atttctttca tctgcttaag agtcagattg gcagcgcttc
    20401 ccatttcggt tagtcctgta ataacattat tggtggcttt agcatcatat ttttttaaga
    20461 ttgggtaagc aacgttgtag aaatcaatca tactgtcatc aaatgttagc catacaactt
    20521 ttttagcagg caattcatta tttgaaagag cgcggtagac ctcttcagga ctcaaaaaat
    20581 agtagccctc gtctttcatt ttttgaagtt gttgatcaaa gagatctggg ttgacaatca
    20641 aattagcatt ggccgtctct tcaggggaca ttacatgaat agcatgatac attaaaattg
    20701 ggatcttgac aggtgtttct tgcttggtcc aagttaattt agaatgggcc tttttttgag
    20761 attttgagga attgaaatga gtcttcttaa gttttgtcgt ttcttttttt gccgtctttt
    20821 tgtgatgaaa aagacttatt ttaggtacaa attgagagac atctgacaag ccgaatttgt
    20881 tagacccttg atataaatag aaaatgaggg tcaaaccaag aatgcaggca aataatagta
    20941 taaggttaat gagagtgaag gcttttcttt tttggcgccg tttatgtcta ttgttcatta
    21001 cttgctcctt tttttgatat aagtacctct attgtaacat tttttagaga aaagaaggct
    21061 tgaagtcagc cttttttctt gttttttgga agaacgtgta ttaaggagta aaaaaatatt
    21121 gtcacagata acactttagg aggtagcaaa gactatgtgg ggctggtatt cttatcacgt
    21181 aaaaaaagca atgaagataa aagtgtagtg tactttagaa cttatttgag tgtttggtga
    21241 ggataataaa aaaaagggta ctactctagg ttatctgctg tcactttttt ttatatatgg
    21301 tatactaaag atagatgtga ggtatgaaat gacttatgaa gagactctag aatggattca
    21361 tgatcactta gttttcggca tcaagccagg cttaaaacgt atgctttggg ttcttggaca
    21421 gttaggaaat ccccaaaaaa atgtcaaggg agtgcatatc gttggaacta acggaaaagg
    21481 ttccacggtt aatcatttac aacacatctt tacgacagct ggttatgaag tggggacctt
    21541 tacctctcct tatattatgg atttcaaaga acgtattagc ataaatggtc gaatgatttc
    21601 agaaaaagat ttggttattg ctgctaatcg tattcgtcct ttgacagagc gtctagttca
    21661 agagactgat tttggagagg taactgaatt tgaagtgatt actttgatca tgttcctcta
    21721 ttttggtgat atgcatcctg tagatattgc tattattgaa gcaggccttg gcggtcttta
    21781 tgattcgacc aatgtttttc aagcaatggt tgtggtctgt ccctcaattg gtttagatca
    21841 ccaagctatt ttgggagaga cttacgctga tattgccgcc caaaaagctg gtgttttaga
    21901 agggggcgag acccttgttt ttgccgttga aaacccgtca gctcgagagg tttttttaac
    21961 aaaagctgag caggttggtg cttcaatctg ggaatggcaa gagcagtttc aaatggttga
    22021 gaacgcatct ggctatcgtt ttactagtcc tttaggagtt atttcagata ttcacatcgc
    22081 tatgccagga caccaccaag tgtctaatgc agctttagct attatgactt gcttaacctt
    22141 gaaagaccgc tatcctaggc taacttcaga tcatataagg gaaggtctag caaatagttt
    22201 gtggctaggc cgtaccgaat tattagcacc aaatctaatg attgatgggg ctcataacaa
    22261 tgaaagcgtt gctgctttgg tagccgtctt aaaaaataac tacaatgata aaaagcttca
    22321 tattttgttt ggtgcgatcg acaccaagcc tattgcagat atgttggttg ctcttgagca
    22381 aataggtgac ttgcaggtta ctagctttca ttaccctaac gcctatccat tggaaaaata
    22441 cccagaacat tttggtaggg ttgctgattt caaagatttc ttggccctgc gtaagcatgc
    22501 taaagcagat gactttttcg tgattacagg gtcactatat tttatttcag aaattagacg
    22561 gtattggaaa aaacatattg aaaaaagcgt tcttttgacc cattaaaaaa gagaaaatga
    22621 aaaggaaaag gaaaaaacta atgaaaaggg aaagactaat gtctattaat aaggaaaaag
    22681 cagaagcggc catttatcag tttttagagg ctattggtga aaatccaaat cgagaaggtc
    22741 ttcttgacac gcctaaacgg gttgctaaaa tgtatgcgga gatgtttttg ggactgggaa
    22801 aagatcctaa agaggagttt acggctgtct ttaaagaaca ccatgaggat gtggtgattg
    22861 tcaaagacat tagtttttat tctatatgtg aacaccactt agttcctttt tatggcaagg
    22921 ctcatatcgc ttatttacca agtgatggtc gagtaacagg tttgagtaaa ttagcgcgag
    22981 cagttgaagt agctagtaaa cgacctcaac tccaagagcg tttgacctct caaatagcag
    23041 atgctttagt tgaagccctc aatcctaaag ggactttagt tatggtagaa gcagagcaca
    23101 tgtgcatgac catgcgaggc atcaaaaagc caggtagtaa aaccattacc accactgcca
    23161 gaggcttata taaggaaagt cgtgctgaga ggcaagaagt tatttctcta atgacaaaag
    23221 attaggagaa cttatgaaaa ttggaaagtt tgtgattgag ggcaatgcgg ctatcatggg
    23281 gattttaaat gtgactccag attctttttc agatgggggg tcttacacta ctgtgcaaaa
    23341 agcattagat cacgttgagc aaatgattgc tgatggggct aaaatcatcg acgttggtgg
    23401 agaatcaaca cgtccaggtt gccaatttgt aagcgctacc gatgaaattg accgggtggt
    23461 tcctgtgatc aaggccatca aagaaaacta tgatattcta atcagcattg atacctataa
    23521 aaccgaaaca gctagagcag ctttagaggc gggtgccgat attctcaatg atgtttgggc
    23581 aggtttgtac gacggtcaaa tgtttgcctt agcagccgag tacgatgcgc ctatcatctt
    23641 gatgcataac caagacgaag aagtttatca agaggtaaca caagacgttt gtgattttct
    23701 aggcaataga gcacaagcag ctcttgatgc tggcgtgcca aaaaacaata tttggattga
    23761 tccaggattt ggatttgcca aatctgttca acagaatatg gagttattaa aaggattgga
    23821 ccgcgtctgt cagttgggtt atcctgtctt gtttggtatt tcgagaaagc gtgtcgtaga
    23881 tgccttgtta ggcggcaaca ccaaagctaa agagcgagac ggagcgacag cagccttgtc
    23941 tgcttatgcc cttggaaaag gctgtcagat tgtacgcgta cacgatgtca aggctaatca
    24001 agacattgtg gctgttttga gctagttgat gtgaggactt atggataaaa tcgtattaga
    24061 aggttgccgt ttttatggct accatggagc ctttaaagaa gaacagaccc ttgggcaaat
    24121 ttttctggtt gatttagaat tgtcagtcga tttgcaagca gcttctttgt cagaccaatt
    24181 aacagatacg gtccattacg ggatggtgtt tgatagtgtc cgtcagttag
//
