LOCUS       NZ_LS483337            23767 bp    DNA     circular CON 13-FEB-2024
DEFINITION  Streptococcus pyogenes strain NCTC12047 chromosome 1, complete
            sequence.
ACCESSION   NZ_LS483337
VERSION     NZ_LS483337.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Doyle,S.
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2018) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 01:05:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,789
            CDSs (total)                      :: 1,700
            Genes (coding)                    :: 1,640
            CDSs (with protein)               :: 1,640
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 29 of 60
            Pseudo Genes (incomplete)         :: 31 of 60
            Pseudo Genes (internal stop)      :: 23 of 60
            Pseudo Genes (multiple problems)  :: 19 of 60
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:22:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 578351
            Orig. end                         :: 602118
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LS483337.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23767
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="2"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23767
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23767
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13767](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13767
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(952..2493)
                     /locus_tag="DQL03_RS03105"
                     /old_locus_tag="NCTC12047_00617"
     CDS             complement(952..2493)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011284650.1"
                     /locus_tag="DQL03_RS03105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00617"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_111674873.1"
                     /transl_table=11
                     /translation="MLHLHLETKLQDKLSLLNILLDVSEVSIDQLCQETELKKQRVYNL
                     LIEMIKDLEDTLTLTICDDTVSIPYKTYQLKMPYFKKLYQTSIFLKMLCFLIEPGELSL
                     HDFIKREYISQATAYRIRTNCRKYLKKVGLNVRQNHVVGPEYRIRFLIALLHYQFGMTI
                     YDFDKTSMNKVVSLIINSNQAITLNDASKAPYEFSYFAILISLIWKRRHDNLGIPQTDA
                     FKHLKKLSIYRDIKMTSQEIIGKWYHPDLTDEDLDYIFLCFCTTNNPFHKDKWTPKKVK
                     ELFELVMTKTIGKTLKASLRPLLGDNILKSLPFKRILVSFSRLFISNLQVLLPDIHLFH
                     YLRRQQKRNKSFYNTLKTIVEEWMSAEGIVGKLPSYHLLLFTIQLEELLKTYLPPIPVY
                     LLTNNTAALDLMTNALSIYFPPAIATVMPVNVEIIPFKDIVKEKQSVIIADRQYLNLIQ
                     HLYQNQGHLFLYFLFSFIDVSEAYIHKAFLDFRQKRYDEFIVTLLDTYHKNLSSP"
     gene            2966..9136
                     /locus_tag="DQL03_RS03110"
                     /old_locus_tag="NCTC12047_00618"
     CDS             2966..9136
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011285469.1"
                     /locus_tag="DQL03_RS03110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00618"
                     /product="DUF1542 domain-containing protein"
                     /protein_id="WP_172449935.1"
                     /transl_table=11
                     /translation="MFLKHQDVKQKNWRMRKVKKLFVSSCMLLTVGLGVAVPTGFSQSN
                     GVMVVKADVTQEGSPENVLKIANSLKATTDGTKIGRYSAINTQNLDVSEYKFYYVNSTK
                     LNKNPQQRLWHYEKPKEIYDSTIRVAGDGTANIRFYADGDGSKTPNGFSFAYKFNTTNL
                     KTDHKYKLSFKQTQNNDEEVYTKYLVGKASEGVANYLTSEETSVARNVELFEGNQKTTA
                     ERKFAKHQSGEKSLQFISKTDGTASLVLAAGVKNTPKKNTDITFDSFEFIDITEPAQVS
                     SGEAIAGNKNLTVNLSGSDGRKNFSGEIIEVYKNGQLLKKETVTTAGNKVNIALGDDVV
                     LKKDDEITFKVKQGSSGKKNQAAGKIIVQQNPAVVAEQENSKKSLEEVYNKAKKAISDD
                     EWLSDEEKRVQTAAVEKTYNEGQTSINNAETVTEIKDAFKKYSTQGNKISIPDQYKKGE
                     KAIKQEQARKSLKQVHEDTLGKIRSDDWLTEEEKATQTENAKQSYNQGENKINQSDSLK
                     TLNQILKDYTSEEPNKKESIPNKYEKGKKEELKRDAETKLREAQETTKQAIENDPWLSP
                     EQKKAQKENAKARLDAGLKAVETTESLDKLKEVESDFLDKEKNPDSIPNQHKAGTPEVA
                     RKTFLDNFEKEAKKEIESIDKDDTLTANAKQVAKDKVAQQLQEATAKVEKAQSFDDLKK
                     VETEFVTALPHTKGEKLNQQQTEAISGLEGVQKATEKAISEDKTLSKDEKKKQIADSKE
                     RLKSDTQKVKDAKNADAIKKAFEEGKVDIPQAHVPGDLNKDKEKLLAELKQKADDTEKA
                     IDSDKTLTAKEKEEQKAKTKEELQKATEAVGAIDNREELDKKVPELKKAIEDTHVKGNL
                     EGVKNKAIEDLKKVHDETVAKINGDDTLDKATKEAQVKEADKALEAGKEAITKADDADK
                     VSTAVTEHAPKIKAAHKTGDLKKAQVDANTALDKAAEKEREEINNDITLAAKDKEQQLK
                     EVETALTKAKDNVKAAKTADAINDARDKGVATIDAVHKAGQDLGARKSGQVAKLEEAAK
                     ATKDKISADPTLTSKEKEEQSKAVDAELKKAIEAVNAADTADKVDDALGKGVTDIKNQH
                     KTGNPVEARREAHSKELDRVAQETKGAIEKDPTLTTEEKAKQVKNVDAAKERGMAKLNE
                     AKNADELDKAYGEGVTDIKNQHKSGDPIEARRGLHNKSIDEVAQATKDAITADTTLTEA
                     EKETQRGNVDKEATKAKEELAKAKDADELDKAYGEGVTDIKNQHKSGDPIEARRGLHNK
                     SIDEVAQATKDAITADTTLTEAEKETQRGNVDKEATKAKEELAKAKDADALDKAYGDGV
                     TSIKNQHKSGKGLDVRKDEHKKALEAVAKRVTAEIEADPTLTPEVREQQKAEVQKELEL
                     ATDEIAEAKDADEADKAYGDGVTAIENAHVIGKGIEARKDLAKKDLAEAVAKTKALIIE
                     DKTLTDDQRKEQLSGVDTEYAKGIENIDAAKNAAGVDKAYSDGVRDILAQYKEGQNLDD
                     RRNAAKEFLLKEADKVTKLINDDPTLTHDQKVDQINKVEQAKLDAIKSVDDAQTADAIN
                     DALGKGIENINNQYQHGDGVDVRKATAKGDLEKEAAKVKALIAKDPTLTQADKDKQTAA
                     VDAAKNTAIAAVDKATTADGVNQELGKGITAINKAYRPGEAVKARKGAAKADLEKEAAK
                     VKALIAKDPTLTQADKDKQTAAVDAAKNTAIAAVDKATTAEGINQELGKGITAINKAYR
                     PGEGVKARKEAAKADLEKEAAKVKALITNDPTLTKADKAKQTAAVAKALKAAIAAVDKA
                     TTAEGINQELGKGITAINKAYRPGEGVKARKEAAKANLEKVAKETKALISGDRYLSETE
                     KAVQKQAVEQALAKALGQVETAKTVEAVKLAENLGTVAIRSAYVAGLAKDTDQATAALN
                     EAKQAAIEALKQAAAETLAKITTDAKLTEAQKAEQSENVSLALKTAIATVRSAQSIASV
                     KEAKAKGIAAIRAAYVPNKAVAKSSSANHLPKSGDANSIVLVGLGVMSLLLGMVLYSKK
                     KESKD"
     gene            complement(9322..>9438)
                     /locus_tag="DQL03_RS03115"
                     /pseudo=""
     CDS             complement(9322..>9438)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611995.1"
                     /locus_tag="DQL03_RS03115"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="QETFYSLEQLTLKTKEEVHWWNYHHLRSNLNYQTPITK"
     misc_feature    complement(9462..9475)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.06"
                     /tool="antismash"
     gene            10001..10162
                     /gene="sagA"
                     /locus_tag="DQL03_RS03120"
                     /old_locus_tag="NCTC12047_00619"
     CDS             10001..10162
                     /codon_start=1
                     /gene="sagA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03602"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985285.1"
                     /locus_tag="DQL03_RS03120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00619"
                     /product="TOMM family cytolysin streptolysin S"
                     /protein_id="WP_002985285.1"
                     /sec_met_domain="TIGR03602 (E-value: 1.7e-29, bitscore:
                     98.4, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQGG
                     SGSYTPGK"
     misc_feature    complement(10169..10186)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.53"
                     /tool="antismash"
     gene            10384..11334
                     /gene="sagB"
                     /locus_tag="DQL03_RS03125"
                     /old_locus_tag="NCTC12047_00620"
     CDS             10384..11334
                     /codon_start=1
                     /gene="sagB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922108.1"
                     /locus_tag="DQL03_RS03125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00620"
                     /product="streptolysin S biosynthesis dehydrogenase SagB"
                     /protein_id="WP_010922108.1"
                     /sec_met_domain="PF00881 (E-value: 1e-32, bitscore: 110.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTKEQQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVLK
                     TSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVYES
                     QEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASIRDG
                     ASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSEENVRDF
                     AEYGAINAENCNIIIIYVYHYMKNTRKYGNQATAYAFIESGEIAQNIQLTATALTYGSI
                     DIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     aSDomain        11331..11600
                     /aSDomain="Cytolysin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing discrete C protein in a
                     SLS/cytolysin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DQL03_RS03130_Cytolysin_C_RRE.1"
                     /evalue="2.40E-42"
                     /identifier="RREFam014.1"
                     /label="DQL03_RS03130"
                     /locus_tag="DQL03_RS03130"
                     /protein_end="90"
                     /protein_start="0"
                     /score="134.1"
                     /tool="antismash"
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLML"
     gene            11331..12389
                     /locus_tag="DQL03_RS03130"
                     /old_locus_tag="NCTC12047_00621"
     CDS             11331..12389
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03603"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985275.1"
                     /locus_tag="DQL03_RS03130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00621"
                     /product="streptolysin associated protein SagC"
                     /protein_id="WP_063629060.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 1.5e-40,
                     bitscore: 134.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03603 (E-value: 2.6e-140, bitscore:
                     464.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLMLEDDYNLEENVMKIL
                     MGNFRFMAQAGHMVSNAPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQTDV
                     SSRLDALEHRRNMNCLSDALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIGFVDG
                     PFLHTCTLNPPHSADFDSLERRVLARLQDSTLYQHFANQILPATQDVSQAYLPLLNVLM
                     NLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLKYEDQQI
                     STREIVKKLLDE"
     gene            12409..13767
                     /locus_tag="DQL03_RS03135"
                     /old_locus_tag="NCTC12047_00622"
     CDS             12409..13767
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407460.1"
                     /locus_tag="DQL03_RS03135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00622"
                     /product="YcaO-like family protein"
                     /protein_id="WP_002990434.1"
                     /sec_met_domain="YcaO (E-value: 6.4e-63, bitscore: 210.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 3.9e-111, bitscore:
                     368.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKSI
                     TGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRIVY
                     ASYNELKLLHKVMPLEYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFFEDA
                     EMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEYIQIDSMMLSW
                     YTKKPCPKIIVDDPDIEVILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILKNKYDE
                     GPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLFLDLDSN
                     VFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKVSPNAVFL
                     DITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHPMP"
     gene            13742..14413
                     /locus_tag="DQL03_RS03140"
                     /old_locus_tag="NCTC12047_00623"
     CDS             13742..14413
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017602.1"
                     /locus_tag="DQL03_RS03140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00623"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_002985272.1"
                     /sec_met_domain="Abi (E-value: 1.1e-10, bitscore: 38.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYAFNLIGFLRAT
                     LIYDILALVSIYVLSPQITLSLESIDSKTFFMGLVFCVLIVLIELVFLHGLRCWQKKQW
                     LPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWHLPTIIVLIVTSFCYA
                     LNHLLMGKSIFYAKLVTGIIYGSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKKKKEV
                     T"
     gene            14410..15093
                     /locus_tag="DQL03_RS03145"
                     /old_locus_tag="NCTC12047_00624"
     CDS             14410..15093
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985270.1"
                     /locus_tag="DQL03_RS03145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00624"
                     /product="SagF family protein"
                     /protein_id="WP_111674874.1"
                     /transl_table=11
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLVALSYQDFLDVL
                     LSLFQFVVIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIEMTLLVLIL
                     IFDVLLQKDSRLLLKKITWLPFRQDKPVLSILLLGTVILVDSLFYLGLLILLGEQSLTS
                     LATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGAMILTVTYLMI
                     SCKEY"
     gene            15116..16039
                     /locus_tag="DQL03_RS03150"
                     /old_locus_tag="NCTC12047_00625"
     CDS             15116..16039
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011017604.1"
                     /locus_tag="DQL03_RS03150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00625"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_111674875.1"
                     /transl_table=11
                     /translation="MSFVQLTNVVKSYKNGKKAANDVSLSIEAGNIYGLLGPNGAGKST
                     LINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGSLY
                     GLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDEPTV
                     GIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPKFELE
                     KRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQLTQANI
                     TFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            16048..17175
                     /locus_tag="DQL03_RS03155"
                     /old_locus_tag="NCTC12047_00626"
     CDS             16048..17175
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985266.1"
                     /locus_tag="DQL03_RS03155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00626"
                     /product="SagG family ABC transporter permease subunit"
                     /protein_id="WP_110002808.1"
                     /transl_table=11
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFNT
                     ATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLEAKPSNSLEKDRQRVSEGALTA
                     VLEVKKNQTIKVITNNINQQNADLINILVKNYVDNAKTYDSIAALYPQQLNHIRKRSVD
                     YVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRTTNRIHLTGVSPS
                     LLVFGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLIGITASLVYLSVAIGIGLG
                     ISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDSLFYLIF
                     GGQYNPIPVTLIVNISIGTIFIILALIGMRKQVTT"
     gene            17172..18290
                     /locus_tag="DQL03_RS03160"
                     /old_locus_tag="NCTC12047_00627"
     CDS             17172..18290
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002990425.1"
                     /locus_tag="DQL03_RS03160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00627"
                     /product="ABC transporter permease"
                     /protein_id="WP_010922112.1"
                     /transl_table=11
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQAK
                     IGILDKDNSQISKQFIAQLKQNKKYDIFTKIKKEHIDHYLQDKSLEAVLTIDKGFSDKV
                     LQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQLNY
                     DVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSNLSRF
                     RYMLSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLIIFFLFSLLAIGFGLLIGA
                     ITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIAIFQSGG
                     TLSQAWPYLLALMGTALALISFSSLLLKPTKL"
     misc_feature    complement(18527..18538)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 18.98"
                     /tool="antismash"
     misc_feature    18643..18656
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.35"
                     /tool="antismash"
     gene            18861..21593
                     /locus_tag="DQL03_RS03170"
                     /old_locus_tag="NCTC12047_00628"
     CDS             18861..21593
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985259.1"
                     /locus_tag="DQL03_RS03170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="NCTC12047_00628"
                     /product="SpnA family nuclease"
                     /protein_id="WP_111674876.1"
                     /transl_table=11
                     /translation="MINKKYIIPVSLLTLAITLTSVEEVTSRQNLTYANEIVTQRPKRE
                     SVISDKSNFPVISPYLASVDFGERKTPLPTPDKGVKVTTEQSIAQVRKGPEERTYTVTG
                     KITSVINGWGGYGFYIQDSEGIGLYVYPQKDLGYSKGDIVQLTGTLTRFKGDLQLQQVT
                     AHKKLELSFPTSVKEAVISELETTTPSTLVKLSHVTVGELSTDQYNNTSFLVRDDSGKS
                     IVVHIDHRTGVKGADVVTKISQGDLINLTAILSIVDGQLQLRPFSLEQLEVVKKVTSSN
                     SDASSRNIVKIGEIQGASHTSPLLKKAVTVEQVVVTYLDDSTHFYVQDLNGDGDLATSD
                     GIRVFAKNAKVQVGDVLTISGEVEEFFGRGYEERKQTDLTITQIVAKAVTKTGTAQVPS
                     PLVLGKDRIAPANIIDNDGLRVFDPEEDAIDYWESMEGMLVAVDDAKILGPMKNKEIYV
                     LPGSSTRPLNNSGGVLLPANSYNTDVIPVLFKKGKQIIKAGDSYKGRLAGPVSYSYGNY
                     KVFVDDSKNMPSLMDGHLKPEKTNLQKDLSKLSIASYNIENFSANPSSTKDEKVKRIAE
                     SFIHDLNAPDIIGLIEVQDNNGPTDDGTTDATQSAQRLIDAIKKLGGPTYRYVDIAPEN
                     NVDGGQPGGNIRTGFLYQPERVSLSDKPKGGARDALTWVNGELNLSVGRIDPTNAAWKD
                     VRKSLAAEFIFQGRKVVVVANHLNSKRGDNALYGRVQPVTFKSEQRRHVLANMLAQFAK
                     EGAKHQANIVMLGDFNDFEFTKTIQLIEEGDMVNLVSRHDISDRYSYFHQGNNQTLDNI
                     LVSRHLLDHYEFDMVHVNSPFMEAHGRASDHDPLLLQLSFSKENDKAESSKQSVKAKKT
                     SKGKLLPKTGDSLVYVITLLGTASLLVPILLLAKGKKES"
     regulatory      21758..21873
                     /bound_moiety="preQ1"
                     /db_xref="RFAM:RF01054"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01054"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="PreQ1 riboswitch class II; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            21871..22371
                     /locus_tag="DQL03_RS03175"
     CDS             21871..22371
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002985256.1"
                     /locus_tag="DQL03_RS03175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="QueT transporter family protein"
                     /protein_id="WP_002985256.1"
                     /transl_table=11
                     /translation="MTKLTVHDYVHIGLVAALYVVLTITPPLNAISYGMYQFRISEMMN
                     FLAFYHRKYIIAVTLGCMIANFYSFGLIDVFVGGGSTLIFVTLGVILFSKYQKDYLFNG
                     IFNKAFVYFSFFFATSMFTVAIELYFFGAPFLLTWFTTALGELVSLLIGSLIIDKLSQR
                     ISF"
     misc_feature    complement(23598..23612)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.38"
                     /tool="antismash"
     misc_feature    23624..23635
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.03"
                     /tool="antismash"
ORIGIN
        1 ttcgccaata atacttgttg cagttgtttc tgcgatactt ggaatagagc gtagaatctt
       61 gtcttctggt aaaggttgag ccaacgccac catcttatca aaaatagctt gacgacgttc
      121 agaaagtcta agtaattctt tggcatagca acgaacctct tctatcatcg gagaggtttt
      181 cgtaacagta aaataagact gcttggctaa tgagacaagt ttttccacta agtagatccc
      241 acgcttgtca gagatacgtt tagaggtaga ttgacggatg atagctgaca atgctttgtc
      301 agctagctct agtacaaagc tattacatgg aaaagccgtt accacattcc agtattactc
      361 accagttggt gcaaataaga tgtgttctag ttcaggaaaa gtgacttgta agatcttgtg
      421 aaggcgattc ttaactctcg aacaatatta tcctcagtca agttttgata gaagcgactc
      481 aagtcacgta gcagctgata aacttcttcc tgaatgtaag ttggttttct aactagaata
      541 aattgagact gagccaattt ttcagtgtct aacttatccg ctttacgcac ccgtagacta
      601 tctagttttc taaaggattg agttgtgtat aagcgtagcc atttttctca aggaaggact
      661 gaagccgacg agaatagact cctgttgtga tggtctccct tttgcctttt aaacaatagt
      721 atagccgttt ttcaaaatgt tattaatgat tttttccttt attctagaag aataagtctg
      781 atactgtttc ttcttaataa tctcaatgcc ctaacaatcc atcagtcgaa cggtatttct
      841 caaattactg cagttgactc ttgcgtttag ttccctcacc ttgtggatgc cgtttagaac
      901 aatattagct tgctgagcct tttggtaatg tgaacaaagc atctttatca ctcaaggaga
      961 agacaagttc ttgtggtaag tgtccaacaa ggtcacgata aactcatcgt accgtttttg
     1021 gcggaagtct agaaatgcct tatgaatgta agcctcagaa acgtctataa aactaaacaa
     1081 gaaatacaag aacaaatgcc cttgattctg gtacaaatgc tgtatcaggt tcaggtattg
     1141 cctatctgcg ataatgacac tctgcttttc cttaacaata tctttgaaag gaatgatttc
     1201 gacattgaca ggcataaccg ttgcaatagc tggcgggaag taaatcgaga gtgcattggt
     1261 catcaaatcc agcgcagcag tgttattggt caaaagatag acaggtatcg gtggcaaata
     1321 tgtttttagg agttcctcta actgtatcgt gaagagcagt aaatgatagg acggcagttt
     1381 ccccacgata ccttctgcgc tcatccattc ctcaacgatg gtttttagag tattgtagaa
     1441 gctcttgttt cgtttttgct gtcttctgag gtaatggaac aagtgtatat caggtaacaa
     1501 aacttgaaga ttactgataa agagacgtga gaaggaaacc aaaatccgtt tgaaaggaag
     1561 ggactttagg atattatcgc ctagtagtgg acgcagggat gctttcaagg tttttccaat
     1621 tgtttttgtc atcaccaact caaacaattc tttcactttt ttaggtgtcc atttatcctt
     1681 atggaaagga ttattggtgg tgcaaaaaca taagaaaata taatccaaat cttcatcagt
     1741 taaatcagga tggtaccatt ttccgatgat ttcctgactg gtcattttga tatctcgata
     1801 gatagacagt tttttcaagt gtttgaatgc atctgtctga gggatcccca agttatcatg
     1861 tcgccgtttc catataaggg atatcaaaat ggcaaagtat gaaaattcat aaggggcttt
     1921 actggcatca ttaagtgtga tggcttgatt ggagtttata atcagcgaaa ccactttatt
     1981 cattgatgtt ttatcaaaat cataaatggt cataccaaac tgatagtgca acaaggcgat
     2041 cagaaagcgg atacggtatt ctggtccaac aacatggttt tgccgaacgt ttaaacctac
     2101 ctttttcaag tatttccgac aattggtcct gatacggtaa gcggtggctt gggaaatata
     2161 ctctcgttta atgaagtcgt gtaggctcag ctctcctggt tcaattaaaa aacataacat
     2221 ctttaagaat atcgaggttt gatagagttt cttaaaataa ggcattttaa gttggtaggt
     2281 cttatagggg atagaaacag tgtcgtcaca aatggttaag gtgagggtgt cttctaaatc
     2341 cttaatcatt tcaatgagta agttgtagac acgttgtttt ttgagttcgg tttcctgaca
     2401 caactggtct atggagactt cggaaacgtc taacaaaatg ttgagcagtg ataatttatc
     2461 ttgtaatttg gtttctagat gaaggtgtaa cataactgaa ctcctttcat ttttatagca
     2521 gaaactcgta tttatttaat tatcacataa ttaaataaaa cagtcaaata attcaatggt
     2581 gacgcgtgtt taaggagtat tgagaatgtc agatataagc aaaatgcagc tgaatattct
     2641 taattttagg tatgaaaaag cgtcgggatt gataaaaaat ctattgaatt gggtaaattt
     2701 aagttgatat aataagttga ttagaaaaat taataattca tttaaattct aatcagctgt
     2761 aacgttccgg ggcgtgttaa actgtctgaa catagaaaat acaggtttct acggtgacta
     2821 aaataagtta aggaggattc cttaaattct gtgataggaa cgtaaactct ctacaagagt
     2881 agagcacgtc atcagtcagt ctgggtgtct actggctgac aacgtcaaat aagataggca
     2941 tgaaaaaaat aagggggaac acagaatgtt tttaaaacac caagatgtga aacaaaaaaa
     3001 ttggagaatg cgtaaggtca aaaaactctt tgttagttca tgtatgcttt taacagtcgg
     3061 cctcggagtt gccgtaccta ctggattcag ccaatctaat ggcgtgatgg tcgtaaaggc
     3121 tgatgttaca caagaaggaa gtcctgaaaa tgttttgaag atagctaatt ctttaaaggc
     3181 tacaactgat ggtacaaaaa taggtagata tagtgcaata aatactcaaa atctagatgt
     3241 ttctgaatat aaattttatt atgttaactc aactaaatta aataaaaatc ctcaacaacg
     3301 cttatggcac tatgaaaaac caaaagaaat atatgattct accattcgag ttgcgggtga
     3361 tggaactgct aatattcgtt tttatgcaga tggagatggt agtaagactc ctaatggatt
     3421 ctcttttgca tataagttca atactactaa tctaaaaaca gaccacaaat ataagttgtc
     3481 gttcaagcaa actcaaaata atgacgaaga ggtttataca aagtatctgg taggtaaagc
     3541 aagtgaaggt gtcgctaatt atttaacatc tgaagaaact tcggtagctc ggaatgttga
     3601 gttatttgaa ggtaatcaaa agacgactgc agagagaaaa tttgcaaaac atcaatcagg
     3661 agagaaatct cttcagttta tttcaaaaac agatggaact gctagtttag ttttagcagc
     3721 tggtgtaaaa aatactccca agaaaaatac agatataacc tttgacagtt ttgaatttat
     3781 tgatataacc gaaccagctc aagttagttc tggagaagcg attgcaggaa ataaaaatct
     3841 tacggtaaat ctaagtggtt cagacggtag aaaaaacttc agcggggaaa tcattgaagt
     3901 ttataagaat ggacaattat taaaaaaaga aacagtaact acggcgggta ataaagttaa
     3961 tattgctttg ggtgatgatg ttgttttgaa aaaagatgat gaaattacct ttaaagtaaa
     4021 gcaaggtagt tctgggaaaa agaatcaagc ggcaggaaaa attattgttc aacaaaatcc
     4081 agctgttgta gcggagcaag aaaactctaa aaaaagctta gaagaagtat ataacaaagc
     4141 taagaaagct atttctgatg atgagtggtt atcggatgag gaaaagagag ttcagactgc
     4201 agcagttgaa aaaacttata atgaaggtca gacttcaatt aataatgcag aaacagtgac
     4261 tgaaataaag gatgctttca aaaaatattc tacgcaaggt aataaaattt ctatacctga
     4321 tcaatataaa aaaggcgaaa aagctataaa acaagaacaa gctcgaaaaa gtttgaagca
     4381 ggtacacgaa gatacattag gaaaaattag atcagatgat tggttgactg aagaagaaaa
     4441 agcaactcaa acagagaatg caaaacagag ttataatcaa ggagagaaca agattaatca
     4501 atcagattct ctgaagacat taaatcaaat attaaaagat tatacttctg aggaacccaa
     4561 taaaaaagaa tcaataccca acaagtatga aaaagggaag aaagaagaat taaaaagaga
     4621 cgctgaaaca aaattaagag aagctcaaga aactactaaa caagctatag aaaatgatcc
     4681 atggttgagt ccggaacaga aaaaagctca aaaagaaaac gctaaagcaa gattagatgc
     4741 aggtttgaaa gctgtcgaaa ctacagaaag cttagataaa cttaaagaag ttgagagtga
     4801 cttccttgat aaagaaaaaa atccagattc aattccaaat caacataaag ctggaactcc
     4861 tgaagttgct cgcaaaactt tcttagataa ctttgaaaaa gaagccaaaa aagagattga
     4921 atctattgat aaagatgata ccttaacggc aaatgctaaa caagtagcta aagataaagt
     4981 ggcacaacag ctacaagaag ctacagctaa agtagagaaa gcacagtcgt ttgatgattt
     5041 gaagaaagtt gagactgaat ttgtaactgc tttaccgcat acaaaagggg aaaaacttaa
     5101 tcaacaacaa actgaagcta tttctggttt agaaggagtt caaaaggcaa cagaaaaagc
     5161 tatctcagaa gataagacac tgtcaaaaga tgaaaaaaag aaacaaattg ctgactctaa
     5221 ggaacgctta aaatctgaca cgcaaaaagt taaagatgct aaaaatgctg atgctattaa
     5281 aaaagcattt gaagaaggga aagtggatat tcctcaagca catgtcccag gtgatttgaa
     5341 caaggataaa gaaaaacttc ttgcagagtt gaagcaaaaa gcagatgata ctgaaaaagc
     5401 gattgattcc gataaaactt tgacagcgaa agaaaaagaa gagcaaaaag cgaaaacaaa
     5461 agaagaactt caaaaagcaa cagaagctgt tggagcaatt gacaatcgtg aagaactaga
     5521 taaaaaagtt ccagaactta agaaagctat tgaagacact cacgttaaag gtaatcttga
     5581 aggtgttaag aataaggcta ttgaagatct taaaaaagtt catgacgaaa cagttgctaa
     5641 gataaatggt gatgatacgc ttgacaaagc tactaaagaa gctcaagtga aagaagctga
     5701 caaagcttta gaagctggta aagaagctat cactaaagca gatgatgctg ataaagtaag
     5761 tacagctgtt acagaacacg caccaaaaat taaagcagca cataaaactg gtgaccttaa
     5821 aaaagctcaa gtagatgcta acacagctct tgacaaagca gctgaaaaag aacgtgaaga
     5881 aatcaataat gatatcacat tagcggcaaa agacaaagaa caacaactga aagaagttga
     5941 gacagctctt actaaagcta aagataacgt gaaagctgct aagacagcag acgctatcaa
     6001 tgacgcacgt gataaaggcg tagcaacaat tgatgccgtc cataaagcag gtcaagactt
     6061 aggtgctcgt aagtcaggtc aagtcgctaa acttgaagaa gcagctaaag caacgaaaga
     6121 caagatttca gctgatccaa ctttgacaag caaagaaaaa gaagagcaat ctaaagctgt
     6181 tgacgctgaa cttaagaaag cgatagaagc tgttaacgca gctgacacag ctgacaaggt
     6241 tgacgatgct cttggtaaag gtgtcacaga catcaagaac caacataaga caggtaaccc
     6301 tgtcgaagct cgtcgtgagg ctcatagtaa ggaacttgat agagtcgctc aagaaactaa
     6361 aggtgcgatt gaaaaagacc ctactttgac gactgaagaa aaagctaaac aagttaaaaa
     6421 cgtagatgcc gctaaagaaa gaggcatggc taagcttaat gaagctaaga atgctgatga
     6481 gttagacaaa gcttacggtg aaggtgttac agacatcaag aaccaacaca agtcaggtga
     6541 ccctatcgaa gctcgtcgtg gattacacaa caagtcaatc gacgaagtgg cgcaagcaac
     6601 taaggacgct atcacagcag atacgacttt gactgaagct gaaaaagaaa cacaacgtgg
     6661 caatgttgat aaagaagcaa ctaaagctaa agaagaactt gctaaggcta aagatgctga
     6721 tgagttagac aaagcttacg gtgaaggtgt tacagacatc aagaaccaac acaagtcagg
     6781 tgaccctatc gaagctcgtc gtggattaca caacaagtca atcgacgaag tggcgcaagc
     6841 aactaaggac gctatcacag cagatacgac tttgactgaa gctgaaaaag aaacacaacg
     6901 tggcaatgtt gataaagaag caactaaagc taaagaagaa cttgctaagg ctaaagatgc
     6961 tgatgcttta gacaaagcgt acggtgacgg tgtaaccagc atcaagaacc aacacaagtc
     7021 aggtaaaggt cttgacgttc gtaaagatga gcacaagaaa gctcttgaag ctgttgctaa
     7081 acgtgtcact gctgaaattg aggctgatcc aaccttaaca ccagaagtga gagaacaaca
     7141 aaaagcagag gttcaaaaag agcttgaact tgcgactgat gagattgctg aagctaaaga
     7201 tgcagatgaa gcagacaaag cttacggtga cggtgtcaca gcgatcgaaa atgcccatgt
     7261 tattggtaaa ggtatcgaag ctcgtaaaga ccttgctaag aaagaccttg ctgaagctgt
     7321 tgctaagaca aaagctctca ttattgaaga caaaacgctt actgatgatc aacgtaaaga
     7381 acagttatca ggtgttgata cagagtatgc taaaggtatc gagaatattg atgcagctaa
     7441 gaatgctgca ggtgttgata aagcatatag tgacggtgtt cgtgacatcc tggcacagta
     7501 caaagaagga caaaaccttg atgatcgtcg taatgctgcc aaagaatttc ttcttaaaga
     7561 agcagacaaa gtgacgaaac taatcaatga tgatccaacc ttgactcatg accaaaaagt
     7621 tgatcaaatc aacaaagttg aacaagctaa gttagacgca atcaagtctg ttgatgacgc
     7681 tcaaacagct gatgctatca atgatgctct tggtaagggt attgaaaaca tcaacaacca
     7741 ataccaacat ggcgatggcg ttgatgttcg taaagcgact gccaaaggcg atcttgaaaa
     7801 agaagctgct aaagtgaaag ctcttattgc taaggatcca accttgactc aagctgataa
     7861 agacaagcaa acagcagcgg ttgacgcagc taagaacaca gcaattgcag cggttgataa
     7921 agcgacaaca gcagatggtg ttaaccaaga acttggtaaa ggcatcacag ctatcaacaa
     7981 agcttaccgt ccaggtgaag ctgttaaagc acgtaaagga gctgctaaag ctgatcttga
     8041 aaaagaagcc gctaaagtga aagctcttat tgctaaggat ccgaccttaa ctcaagctga
     8101 taaagacaaa caaacagcag cggttgacgc agctaagaat acagcaattg cagcggttga
     8161 taaagcgaca acagctgaag gcattaacca agaacttggt aaaggcatca cagctatcaa
     8221 caaagcttac cgtccaggtg aaggtgttaa agcacgtaaa gaagccgcta aagctgatct
     8281 tgaaaaagaa gctgctaaag tgaaagctct tattactaac gacccaacct taacaaaagc
     8341 tgataaagct aaacaaacag cagctgttgc taaagctctt aaagctgcta tcgcagcggt
     8401 tgataaagcg acaacagctg aaggcattaa ccaagaactt ggtaaaggca tcacagctat
     8461 caacaaagct taccgtccag gtgaaggtgt taaagcacgt aaagaagctg ctaaagctaa
     8521 tcttgaaaaa gtagctaaag aaactaaagc tcttatttca ggagaccgtt acttgagcga
     8581 aactgaaaaa gcagtccaaa aacaagctgt tgagcaagct cttgcgaaag cacttggtca
     8641 agttgagact gctaagacag ttgaagctgt taagttggca gaaaatcttg gtactgtagc
     8701 tatccgttca gcatatgttg ctggtttagc taaagatact gatcaagcaa cagctgctct
     8761 taacgaagcg aaacaagctg ctattgaagc tcttaaacaa gctgcggcag aaacacttgc
     8821 taagattaca actgatgcta aattgactga agctcaaaaa gctgaacaat cagaaaatgt
     8881 atcattagcg cttaagacgg ctattgcgac tgttcgttca gcacaatcta ttgcgtctgt
     8941 gaaagaagca aaggctaaag gtattgctgc tatccgtgca gcctatgtgc ctaataaggc
     9001 agtcgcaaaa tcatcgtcag cgaaccatct tccaaaatca ggtgatgcaa actcaattgt
     9061 tcttgttggc ttaggagtta tgtctcttct tttaggtatg gtgctttata gcaagaaaaa
     9121 agaaagtaaa gactaagaac ctggctttat ccaaattgct ttctactata ttttcaaacc
     9181 aaggtgattt tgaaatcacc ttggtttttt ggatcgtaag ggcccaagaa cggattgtat
     9241 tgaaaacatt tcaaagttca attgaaaagg caacagtttt ctgtacagaa tttataaggc
     9301 gttttttgtt caaacgatga ctcatttagt tatgggtgtt tgataattaa gattactgcg
     9361 aaggtgatgg tagttccacc agtggacttc ctccttggtt ttaagggtta attgttctag
     9421 tgaataaaag gtttcttggt cgcgcagtag ggatcaagcg agcagataaa atgcctattt
     9481 taaattagtt cgagcaaatt ttcgtgctac aagctcaaaa gaggctacta aagtattaga
     9541 atagtttatc tctgagtgaa gttcttgtta taagaagatg atgttatcgt ttgaaacgac
     9601 caaaaaatct cctaactttt actaatttct acatgaaatc tagtccagta tttactctac
     9661 aaccttgatt gattcgctta ataaagacat ttctacttga ttgtttacac atagttattg
     9721 atagaatcta ttataaaatt cagtatatta gataataatt gtttctatat taatcaatta
     9781 ttattttttt tgtcattttt gataatatta aaaagaaagg gtttacatat taatcatttt
     9841 ttactataat aaaagtgata agaactagat agttgttgtg ttacaacagt acaattgagc
     9901 tagccttgtc cttgttgtgt taactttatt tttaaaataa ggttaaaaat aaacgactcg
     9961 tgttcttatc agttacttat tagataagga ggtaaacctt atgttaaaat ttacttcaaa
    10021 tattttagct actagtgtag ctgaaacaac tcaagttgct cctggaggct gctgttgctg
    10081 ctgtactact tgttgcttct caattgctac tggaagtggt aattctcaag gtggtagcgg
    10141 aagttatacg ccaggtaaat aatctattta gcatctctat gtgatagtga tattaaggta
    10201 atgagtttgc tagcaactaa gttatctttg gtaacttctg attatagatg aatggcatag
    10261 aggtgttaga aaacatgaga caaaagtaat cttcttgatg ctaacgtctc aggtaattag
    10321 caggtactag acagtacctg ctaattacta tatgtttagt aaaatgagat aggaaagata
    10381 gttatgtcat tttttacaaa ggaacaacaa cctaaagaga attgtccgcc aataactgtt
    10441 gaaaaagcaa ggcaattgtt tgaatttaat acaaaccact tgtccttatc ggattaccat
    10501 catcaaacgg tgctaaaaac gtcaaagcag ctagttgctc aacatttaat gcctaatgca
    10561 accgataatc ttagtcaaca ttttttgatg aactataaag ctaataataa ttatttaggc
    10621 ttccaagcta gtattgtcga cttttttaca gattctgccg ttgctaattt ttcaagtagt
    10681 tacgtttatg aaagtcagga aaagataatt cgtttaccaa aacctaccaa gatatcaact
    10741 gctctgtcga catgtattat aaaacgaaga agtcatcgtc aattttcaga tagacaaatg
    10801 cctcttcaag atttatcaaa cattctttat tatgcatgtg gtgttagttc acaagcatca
    10861 attagagatg gagcatcaga taagattaca ctcagaaact gtgcttcagg tggaggttta
    10921 taccctattc atttagtttt ttatgctaga aacatcagta aattaataga tggtttctat
    10981 gaatatctac cctatcagca tgcactaagg tgttatcggc atagctctga ggaaaacgtt
    11041 agagattttg cggaatacgg tgctattaat gctgaaaatt gtaatattat tattatttat
    11101 gtctaccatt acatgaaaaa tacacgtaaa tatgggaatc aggcgactgc ctatgctttt
    11161 attgaatcag gagaaatagc ccagaatatt caattgactg caactgcctt aacttatgga
    11221 agtattgata ttggtggtta taataaggaa tatctccaag aattattaga tttagatggg
    11281 ctaggagagc atgtgattca catgacactc gtaggaacta aggagtctca atgaaatatc
    11341 aacttaatag taatgttcgt gtcgtgacat ttcaagatac attttgtttt agaaaaggaa
    11401 tctgggactt taatgaagcc attctagatt tgacacaaga acctcaaaat ttaaagatag
    11461 tttatcaaga aatagtttca cagttggtta agggagtagc cattgatact gaaacttatg
    11521 aaaatacttt agaacctgag acgttcgcta atttaatgga agtcatttca ggcttgtatt
    11581 acaatgatat gctgatgctt gaggatgact acaatcttga agaaaatgtc atgaaaattt
    11641 taatgggtaa tttccgtttt atggcgcaag caggtcatat ggtaagcaat gctcctgttt
    11701 tgtttatcag tgattcgact tatgttaatg aatctgctga gttgctagct gaacaactgc
    11761 atttacaatt gcaagtggct agtgatgact taaaaatgtt aattcagcag acagatgtta
    11821 gttcgcgttt agatgctttg gagcatcgcc gtaacatgaa ttgtttatca gatgccttgt
    11881 gcgattacca aagtattatt atttgtcaag aacgcttgaa tattatgatg ttgcgacact
    11941 tgaatgaagt tagcgtagct atgaaaaaac aattagtgat tggttttgta gatggaccat
    12001 tcttgcacac ttgtactttg aatcctcctc atagtgctga ctttgatagc ttagaaagaa
    12061 gagttttggc acgtttacaa gactcaactc tctatcaaca ttttgctaat cagattttac
    12121 cagcaacaca agatgtgagc caggcctatt taccattgtt aaatgtttta atgaatttag
    12181 tcgttagcga agctttcatt attgctcaaa caggtagttc taaatttgag ggacgtttat
    12241 taagcattta cttaccgacg cttgagattc aggtccaaga tattttgaaa atgtctaatt
    12301 cacagacaca aggagctttg gcaaaattaa agtatgagga tcagcagata tcaacacgtg
    12361 agattgttaa aaaactcctt gacgagtaac ctataaggag aatctattat gttatactat
    12421 tatccttctt ttaatcatat ttttgatgaa ttaaaaagtt taagtggcaa tcgaacaggt
    12481 atcttaaatc aatctcaagt tccagtttgc aaccatcctc acgatgttta cttaaaaagt
    12541 attactggcc aaatgccaga ttatcataaa caatttatag gtgagttgag tcaagttagt
    12601 tatcacatta ttggttacgg cagttactat gaagaagcac ttatcaagta tttaggagaa
    12661 agtattgaac gctatgctac tgtaattgcc ggagacttac tatcagatcg gattgtctat
    12721 gcttcttata atgagttaaa actgttacat aaagtgatgc ctttagaata cttgcaagtg
    12781 tttacccaag aacagatcgc attatcttgt gacttgcaaa tgatgatgtg cgataaaatg
    12841 gtaactgaga acgatgtatt gggctgggtt aaatgtccca tgttctttga ggacgcagag
    12901 atgtatgttc cagctcaaat gctttgtgtt gggtataaaa caaatgagac tgtaggagaa
    12961 agacggataa taccaggatt ttctacggga acagcttctc acaaaacgtt agaagcggct
    13021 atgtgcaaca gtttgattga atacatccag atcgattcaa tgatgcttag ctggtatact
    13081 aagaagcctt gccccaagat tattgttgat gatcctgata ttgaagtgat tttagaagaa
    13141 gctagactgg gaaaagacag tctatacgac attattccta tcgatatgac tgtaggagaa
    13201 gataatcctc tttatacgtt tggaatcatt ctcaaaaata aatatgatga agggccttac
    13261 ctcttgtttg gagtgcaggc tgggttagat cctaaacatg ctttgctaag agggatcatg
    13321 gaagcttcag ctatcagcta tagttactac tataatcttt tatatcaaaa agcttccctt
    13381 gcaaatattg aatgcgaaga acctttgttt ttagatttag atagtaatgt tttctattat
    13441 gcacatccca aggaccaaga ccataaatgg aaggcctttg aacctttgat ttcaggagaa
    13501 gttctgttaa gtgatttgga agatcattct ggtaaagata aaaaagaaga tttgaagact
    13561 ttattagctt atgctaagaa agtcagtcct aatgctgtct ttttagatat tacacctcct
    13621 gaagctctag aaaaaggctg gtacgtcacg cgagttctga tgccagaact tcttgaaatg
    13681 tgtataccag catttccttt tgctaatcat ccacgaatga gacagtttgg aggtgtaaca
    13741 aatgcctttg tccatccaat gccttaatct ttgttttttg ttggtaactt tttgtccttc
    13801 aattcctatg caagctattt ttggaaaaga agatagtggt tatgcattta atttaattgg
    13861 ttttctaaga gcaactctga tttatgacat tttggctttg gtaagtattt atgttttgtc
    13921 acctcaaata accttgtctc ttgaaagtat tgatagtaag acgttcttta tgggacttgt
    13981 attttgcgtc ttgatagtac tgattgaact cgttttctta catggtttac gttgttggca
    14041 aaaaaagcaa tggcttcctg caactttctc gtttgtagga acgacaaatg attggtctaa
    14101 gattggctat cctttattac tagctttatt tgaagagacg atttatcgtt ttttgtggtt
    14161 taatatatta gcttttcaat ggcatttacc aacaattatt gttttaattg taactagttt
    14221 ttgctatgct ttaaatcact tattgatggg gaaatccatt ttttatgcta agttggtaac
    14281 aggcatcatt tatggtagta tttacatgct gactagtcaa ttgtggttgg ttgtgataat
    14341 gcatgtagga ggtaacttgc tagttgagtg tcttagccat cttcaaacaa aaaagaagaa
    14401 ggaggtgaca tgatgctatt ggttttgctg tcgtttttag gtctaactac tctttggttg
    14461 accagttatc gaagacgttg tttggctaga tggcatcttc aatggttagt ggccttatcc
    14521 tatcaagatt ttttagatgt cttactgagt ctgtttcaat ttgtcgttat tatacttgtt
    14581 ttgttctttt actcagctac tattaatcta ggagaggttc tgaccttttt gacacaaact
    14641 agctggcatt ggcagattct ttgttattta gtgttatatc ttatggccat catagagatg
    14701 acgcttttag ttttaattct tatctttgat gttttgctcc agaaagacag tcgattgctc
    14761 ttaaaaaaaa taacttggct gccttttaga caagataaac cagtcttaag tatactttta
    14821 ctaggcacag ttattctagt agacagtctc ttttatttgg gcttgcttat attattagga
    14881 gaacagtcgc taacaagttt agcaacgctt attttaggtt atgggatagt caaggcttgt
    14941 cgctattcag gttggttaaa tgtactatta gctttttgtc ttttcactat agttggacta
    15001 tgggcagtta cggcaacttt attatatggt tggctagtag gtgcgatgat attaacggtg
    15061 acttatttga tgattagttg caaagagtat tagcaatatt aaaaaggagt gatatatgag
    15121 ttttgtacaa ttaacaaatg ttgtcaagtc ctacaaaaac ggcaagaaag ctgccaatga
    15181 tgtttccttg tctattgaag caggtaatat ttatggtttg ttaggaccaa atggtgctgg
    15241 taagtctacc ttgattaatc ttatcttagg cttgatccct ttgagttccg gtaaaattac
    15301 tgttttaggg caatcccaaa agactattcg aaaaataagt tcgcagatag gttatgttcc
    15361 tcaagacatt gctgtttatc cagacctaac tgcttatgaa aatgtagaac tatttgggtc
    15421 actttatggc ttaaagggag ctcagcttaa aaaacaagtt ctaaaaagtt tagaatttgt
    15481 ggggctacac tcccaagcta agcagtttcc aagtcaattc tcaggaggaa tgaagagacg
    15541 gttaaatatc gcttgtgcgc tagttcattc acctaaatta atcatttttg acgaaccgac
    15601 tgtagggatt gatcctcaat cacgtaatca tattttagag tcgattcgtt tgctaaacaa
    15661 agaaggtgct acagttattt atacgaccca ttatatggaa gaagtagagg ctctttgtga
    15721 ttatattttt attatggatc atggtcaagt tattgaagaa ggacctaaat ttgaactgga
    15781 aaaacgttac gttgcaaatc tagcaaacca gattattgta actctaacag attcacgtca
    15841 tttggaactg gcagataagc ctgattggtc tttgatagaa gatggagaaa aactcatgtt
    15901 gaagattgat aatagtgata tgacatcagt tgttcatcag ctcacacagg ccaatattac
    15961 ttttagcgag attagacata accatttgaa tttagaagaa attttcttac acttaacagg
    16021 taagaagtta cgagattaga ggttactatg gttttatttc atttaatcaa aaaagaaagt
    16081 ttacagattt ttagaaaccg aacagcctta ttgatgatgg tgatttttcc aattttgatg
    16141 atcgttattt taagttttgc ctttaaatca agttttaata ctgcgacaac agtccctaaa
    16201 ttgaccattc gttaccaatt agagggtgaa aaaacggatt accagaaaaa ttttcttgct
    16261 tttttaaaag ttttaaacca aaaacttcat ttagaggcta aacctagtaa ttctcttgaa
    16321 aaagatcgac aaagggtcag tgaaggagcc ttaacggctg ttttagaagt gaagaagaat
    16381 cagaccatta aggttattac taataatatt aatcagcaaa atgcagattt gatcaatata
    16441 ctagtaaaaa attatgtaga taatgctaaa acttatgact cgatagcagc tctttatcct
    16501 caacaattaa atcatatcag aaagcgaagt gtggactatg ttaaggtcag ttcaatacag
    16561 acaagtaaag gaatgacatc agctgattat tatgctattt ccatgtttac catgattact
    16621 ttttatagta tgatgtctgc gatgaacctt gttttgtcag atcgtcaaca acggactaca
    16681 aatcgtattc acttaacagg agtttctcca agtcttttgg tctttgggaa attaataggt
    16741 gctatgttag caacaactgt tcaattgagt cttttataca tttttacaag gtttgtttta
    16801 cgagttaatt ggggcactaa tgagtggatg cttattggta taacagcctc cttagtctat
    16861 ctctctgtag ctataggtat cgggctaggc ataagcatta aaaatgaggc ttttttaacg
    16921 gttgcatcca atactattat tcctatattc gcctttttag gaggcagtta cgttccattg
    16981 acaacattac acagctctat tattaatcaa ttgtcgaata tatctcctat taaatgggtt
    17041 aatgatagtt tgttctatct tatttttggt ggtcaatata atccgattcc tgtaactttg
    17101 atcgttaata ttagtatcgg aacaattttt ataatattgg cattgatagg tatgagaaag
    17161 caggtgacga catgatttgt tttataaaaa ctctatttgt taagataaag cgcaaaaaaa
    17221 caagttacgt gacattcttt ttaatgccta ttttaacgac acttttggct ttatctttga
    17281 gtttttcaaa taataatcag gctaaaattg ggatattaga taaagataat agtcagatat
    17341 ctaaacaatt tattgctcaa ctaaagcaaa acaaaaagta cgacattttt accaaaatca
    17401 aaaaagagca tattgatcac taccttcaag ataaatctct agaagcggta ttgactattg
    17461 acaaaggatt ctcagataaa gtgttgcaag gaaaatctca aaaactcaat atacgttcga
    17521 ttgctaatag cgaaattaca gagtgggtaa aggcacagac caattatcta ttggaaaatt
    17581 ataatattat aggggatgtg gctctaggta acgaagatac ttttaataga attctccaaa
    17641 aaaaccaaca gttaaattat gatgttaagc aagtaacttt gacagaccga tcacgtagca
    17701 aagcagtatc ttccacaacg acaggatttt tgcttattct aatgttaggt agtacgagcg
    17761 tgatttacag tggtattttg gcagataaat ctagtcagtt ataccatcga ttaatgttat
    17821 cgaacttatc tcgttttcgc tatatgttga gttacgtctg tgtaggattt gttgctttta
    17881 cgattcaaat tgtcattatg ctgagtttgt taaaagtatt taatattagt ttttttgttc
    17941 cgacatcact tcttttgatt atttttttcc tttttagttt attagcgata ggctttggcc
    18001 tgctgattgg agctatcaca caaaattccc aacaaagtag ccagttagct aatcttattg
    18061 taatgccgac ttcaatgttg gctggctgtt tatggccatt gtctattacg ccttcttata
    18121 tgcaagcaat tggtaagtta ttaccacaaa attgggtttt atcagccata gctatttttc
    18181 aaagtggagg gaccttatct caggcttggc catacttgtt agctctaatg ggaacagcac
    18241 tagctttgat tagtttttca agtttattat taaaacctac caaactataa ttagtctttt
    18301 gttagaaaat actttcctaa ttagctaact accaggtagc ccttttattg gcttatatgc
    18361 aataaaaggg ttgctttttg cttatatttt ctctagtgca cttatctttt gttaaaagcg
    18421 attgcgatgt tactgttgtt attgtgtttt ttagagagca tattatcaaa agcgacccct
    18481 ctataaagtt cgtttttgtt gataaatggg ttgtcaaagt attttaaaaa acgttttcaa
    18541 taaacataaa aactaatgtt attaaaaaaa gttttgaaaa cgtatttatt ttatgaaatg
    18601 tttttgttac aataagcatg tatcgaatgc tataaagctg tcttgttcgc tatcaagggt
    18661 gcttgtgatg ttatgtcaga tcaaacaagt atttaattgg gtgacttaac agattaaaag
    18721 aaaagatcta atcgtgttac ttgatagtat aattaatgca aacagaaagt gtatcccaat
    18781 tcatagtctc aggtggaggt taatattcaa aaataaaatc ttgttgttgt cttaaactaa
    18841 tcacattaaa aggagatatc atgattaaca agaaatatat aatacctgtt tcattgttga
    18901 cactagctat tacgcttact agtgttgaag aagttacttc acgccaaaat ttgacttatg
    18961 ccaatgaaat cgtaacacaa aggccaaaga gagaatctgt tattagtgat aaatcgaatt
    19021 ttcccgtcat atcaccttac ctagcaagtg tggattttgg tgagagaaaa acacctttgc
    19081 caacacctga taaaggagta aaagtaacta ctgaacaatc tattgctcaa gtaagaaagg
    19141 ggcctgaaga aagaacctat actgttactg gcaagattac gagtgtgatc aatggctggg
    19201 gaggctatgg cttttatatt caagatagtg aaggtattgg actttatgtt tatcctcaaa
    19261 aagatttagg atacagtaag ggagatattg ttcaattaac aggtacactt actcgcttta
    19321 aaggtgattt acaactccaa caggtgactg cacacaaaaa gttagagtta tcttttccga
    19381 cttctgttaa agaagcagta atatcagaat tagaaacaac aacaccctca acattagtta
    19441 agttatctca cgtgacagtt ggagaattat caactgatca atataacaac acatctttcc
    19501 ttgtaaggga tgatagtggt aaaagtatag ttgttcatat agatcatcgt acaggggtta
    19561 aaggggctga tgttgttact aaaataagtc agggtgattt gattaacctc acagccatat
    19621 tgtctattgt tgatggtcag ttacaattaa gaccgttttc tcttgaacaa ttggaagtgg
    19681 ttaaaaaggt cacaagctca aatagtgatg cttcatctcg taatattgtg aaaataggcg
    19741 agattcaagg agctagtcat acgtcgccac ttctcaaaaa agcggtcacc gtagaacagg
    19801 ttgttgtcac ttatttagac gattccactc atttttatgt tcaagatctt aatggtgatg
    19861 gtgatttagc gacttcagat ggtattcgtg tttttgctaa aaacgctaag gttcaagtcg
    19921 gcgatgtttt gaccatttca ggtgaagtgg aagaattctt tggtcgtggt tatgaggaac
    19981 gtaagcagac tgaccttacc atcacccaaa ttgtggctaa agcagtgacc aaaacaggga
    20041 cagctcaagt tccatcaccg cttgttttag ggaaagatcg tatcgcgcca gccaatatta
    20101 ttgataatga tggcttgcgt gtgtttgatc cagaagaaga cgctattgat tattgggaat
    20161 caatggaagg catgttagtg gcggttgatg atgctaaaat ccttggtcca atgaaaaata
    20221 aagaaattta tgtcttacct ggctctagta caagaccgtt aaataattca ggtggagtat
    20281 tacttccagc taattcttat aacacagatg tgattcctgt tcttttcaaa aaaggcaaac
    20341 aaattattaa agcaggagac tcttacaaag gaagattagc tgggccagta tcttatagct
    20401 atggtaatta caaggtcttt gttgatgaca gcaaaaacat gccaagttta atggatggtc
    20461 atctaaaacc tgaaaaaaca aacttgcaaa aagaccttag caagttaagc attgcttctt
    20521 acaatattga aaacttctca gccaatcctt cttcaactaa agatgagaag gtcaaacgga
    20581 ttgccgaatc ctttattcat gatctgaatg ctccagacat tattggatta attgaagtcc
    20641 aagataataa tgggccgact gatgatggga caacggatgc gacacaaagc gcacaacgcc
    20701 tcattgatgc tattaaaaaa ctaggtggcc caacttatcg ttatgttgat attgctccag
    20761 aaaataatgt tgacggaggt caaccaggtg gtaatattcg aacaggattc ctttatcaac
    20821 cagagcgcgt cagcctttct gataagccaa aaggcggtgc tcgtgatgct ctaacttggg
    20881 ttaatggaga attaaacctt agtgttggtc gaattgatcc aactaacgcc gcttggaaag
    20941 atgttcgtaa atcgctagca gcagaattta tcttccaagg ccgtaaagtc gttgttgttg
    21001 caaatcattt gaactctaag cgtggggata atgctcttta tggtcgtgtg caaccagtca
    21061 cttttaaatc tgagcaaaga cgtcacgtct tggctaatat gctagcacaa tttgcgaaag
    21121 aaggggcaaa acaccaagct aatattgtaa tgttaggtga ctttaatgat tttgaattca
    21181 caaagacgat tcaattaatc gaagaaggtg atatggttaa cttggtgagc cgacatgata
    21241 tttcagatcg gtattcttat tttcaccaag gcaataatca gacccttgat aatatattag
    21301 tttcacgcca tttacttgat cactacgaat ttgacatggt tcatgtgaat tccccattta
    21361 tggaagctca cggacgcgca tcagatcatg atccattgtt acttcaatta tcattttcta
    21421 aagaaaatga taaggcagag tcttctaaac aaagtgtaaa agctaaaaaa acttcaaaag
    21481 gaaaactgtt gccaaaaaca ggagatagtc ttgtttatgt gataacgcta ctaggaacgg
    21541 ctagtttatt agtgcctatt ttattattgg ctaaaggcaa aaaggaatca tagcgatttg
    21601 aagaattgca gttcataaag agtcgttaaa ggtttgatat acttacgtta gaccttaagc
    21661 taaaatggat gactatataa aaactaagat tgataacaaa agaagataac aataagacag
    21721 ctttacttgc taaagacttt tgtcaagcta attgttttat ggtacaatgt aaccgttgct
    21781 ttgcaaccct tggtgcttag ttccctttca ccaagcatat tagaaacgta gatagctttt
    21841 gagagttatc cagacgttaa aggagaaaaa atgacaaaat tgactgtaca cgactatgtt
    21901 cacattgggc tagtagctgc cttgtatgtt gtcttaacta ttaccccacc tttaaatgcg
    21961 atttcttatg ggatgtatca atttagaata tctgaaatga tgaatttctt agctttttat
    22021 catcgcaagt atattattgc ggtgactctt ggatgtatga ttgctaactt ttatagtttc
    22081 ggactgattg atgtctttgt aggcggcggt tcaactctta tttttgtgac cttaggtgtt
    22141 attttgttta gtaagtatca aaaagattat ctttttaatg gtatttttaa taaagctttt
    22201 gtttactttt ctttcttttt tgcaacttcc atgtttactg tagcaatcga actttacttc
    22261 tttggagctc catttttatt aacatggttt acaactgcgt taggagaatt agtatctctg
    22321 ctcataggat cacttattat tgataagttg tctcaaagaa tttcctttta gtaatgcatc
    22381 atactcaaaa gagttgggtc aatacccttc tcttttttat gttgtttgta atgttaaaat
    22441 cgttctagat agaaatattt aacactttag ctaatagtac catatggagt ggccaacgat
    22501 tacttttgat gttgttatga tatagaaata gctcatttgt tatcttttat gataaaataa
    22561 aagtatgaaa aaacgcataa aagaattaac agatcttctt aaccgttacc gttatgacta
    22621 ttatactaaa gatgccccat cagtttctga cagtgactat gataagcttt atcgtgaact
    22681 ggtgacttta gagcagtcat atcccgagta tgtcttgcaa gatagcccaa cgcagcaggt
    22741 tggagggact attttaaagg ggtttgaaaa atatcgacat cagtatccgc tttttagttt
    22801 gcaggatgct ttttcacgtg aggagctgga tgcttttgat aagcgcgtca aggccgaatt
    22861 tccgaatgcc acctatctag cagagttaaa aattgatggt ttatctattt ccttgagtta
    22921 tgagaatggc ttcttacagg ttggagcaac acggggtgat ggcaatatcg gtgaaaatat
    22981 cacagaaaat atcaaaaaaa taaaggatat tcctcacaaa ttgagtgagc ctttaaccat
    23041 caccgttcga ggagaggctt acatgtctcg tcagtccttt aaagcgatca atgaagcacg
    23101 ccaagaaaat ggggagactg aatttgctaa tcctagaaat gctgccgctg ggacactaag
    23161 gcagctagat acgtcagtgg ttgctaagcg tcaactagcc acttttttgt atcaagaagc
    23221 tagtccgaca gctagaaatc aacaaaatga ggtcttagca gaattagcag atctaggttt
    23281 ttcagtaaat ccgtattatc aactcacatc gtctatggat gagatttggg attttatcaa
    23341 aactcttgag gcaaaaagag atcaattagc ttatgacata gatggcgttg ttattaaagt
    23401 taatagccta gccatgcaag aagagctagg gtttacagtt aaagctccac gctgggccat
    23461 tgcttacaaa tttccagcag aagaaaaaga ggcagaaatc ctttcggttg actggacagt
    23521 ggggcgaaca ggcgtggtca cacctacagc gaatctaact cctgtgcaac tagcggggac
    23581 aaccgtgagt cgtgcaaccc tacataatgt ggattatatt gccgaaaaag atatccgtat
    23641 tggcgataca gtgattgtat ataaggcagg ggacattatt cctgctgtct taaatgtcgt
    23701 tatgagtaag cgaaaccagc aagaagtcat gcttattcct aaactatgcc catcttgtgg
    23761 tagtgaa
//
