LOCUS       NZ_LT963352            11440 bp    DNA     linear   CON 13-FEB-2024
DEFINITION  Streptomyces chartreusis NRRL 3882 isolate NRRL3882 chromosome I.
ACCESSION   NZ_LT963352
VERSION     NZ_LT963352.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces chartreusis NRRL 3882
  ORGANISM  Streptomyces chartreusis NRRL 3882
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Wibberg,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-NOV-2017) CEBITEC, Genome Research of Industrial
            Microorganisms (GRIM), Universitaetsstrasse 27, 33615, NRW, Germany
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 02:03:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,073
            CDSs (total)                      :: 7,984
            Genes (coding)                    :: 7,779
            CDSs (with protein)               :: 7,779
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 205
            CDSs (without protein)            :: 205
            Pseudo Genes (ambiguous residues) :: 0 of 205
            Pseudo Genes (frameshifted)       :: 91 of 205
            Pseudo Genes (incomplete)         :: 161 of 205
            Pseudo Genes (internal stop)      :: 14 of 205
            Pseudo Genes (multiple problems)  :: 56 of 205
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2074384
            Orig. end                         :: 2085824
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT963352.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11440
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="10"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11440
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11440
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6440](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6440
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            288..1142
                     /locus_tag="SCNRRL3882_RS09240"
                     /old_locus_tag="SCNRRL3882_1833"
     CDS             288..1142
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325985.1"
                     /locus_tag="SCNRRL3882_RS09240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1833"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_010034067.1"
                     /transl_table=11
                     /translation="MITLLRRATAVCALSTALAACGAGRPPQPPSPPVSAPPSRPPTLA
                     PGPTGLTPVFEHGPRTRGRTVALTFDADMTAGQGARAAAGERFDHPRLISTLRALQVPA
                     TVFMTGRWAEQYPDQARSIGRDPLFEVANHSYSHYAYTPDCYGLPTVPEKRMRSDVERA
                     YAALRKAGVTDPMPYFRFPGGCYDRRALKALTPAGVTAVQWDVVGGDAFETDPEVVARQ
                     VLDGVRPGSVVVLHCTRSAAPATERAVRSIVPGLRREGFRFVKVSELIGAAGSGARTRP
                     EGR"
     gene            1161..1340
                     /locus_tag="SCNRRL3882_RS09245"
                     /old_locus_tag="SCNRRL3882_1834"
     CDS             1161..1340
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675663.1"
                     /locus_tag="SCNRRL3882_RS09245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1834"
                     /product="hypothetical protein"
                     /protein_id="WP_010034064.1"
                     /transl_table=11
                     /translation="MSEDDYCLIDATRPPRADGPPYAECVLCREPTEYPESYKGITLCP
                     VCEWQEAQRTACSG"
     gene            complement(1332..2003)
                     /locus_tag="SCNRRL3882_RS09250"
                     /old_locus_tag="SCNRRL3882_1835"
     CDS             complement(1332..2003)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432054.1"
                     /locus_tag="SCNRRL3882_RS09250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1835"
                     /product="hypothetical protein"
                     /protein_id="WP_010034061.1"
                     /transl_table=11
                     /translation="MTALMGYHAALLLRSQRWLPPFLLYAAFLAISVQAGQPVLDSLGY
                     AAAALLPVAAWLARICVTAEPQAARGCVAAAVGPARAHVACLLVALSGAVTLGTVAALG
                     VTLLSAPVASDHRTPVPLAPACGAGLLAALACALLGTAVGALTSRPLLRSRARAVLALL
                     LAALLSLVATGSPAQAAVQGLVTGSRSGTVPLPLLPLAAAVLVTAAALALAGALAARRS
                     T"
     gene            complement(2000..2866)
                     /locus_tag="SCNRRL3882_RS09255"
                     /old_locus_tag="SCNRRL3882_1836"
     CDS             complement(2000..2866)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993754.1"
                     /locus_tag="SCNRRL3882_RS09255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1836"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_010034060.1"
                     /transl_table=11
                     /translation="MRPDLCLQNAGRRYGLRGPWVLRGVDLTVAPGRLVRVEGANGTGK
                     STLLRLLAGIDAPSEGRITGRPRTAYVPERFPPALPFTAVGYLTHLGAVHGLTRTAAAR
                     AAGEWLERLGAAAYAGTPMARLSKGTSQKIAVAQALLAEPELLVLDEAWTGLDTDARAE
                     LERAVAERTAAGGSVVFVDHDPRRLAGLPDATYAVRDGSLVPCAAPGSGPSGPHVTVVA
                     QGPPDGRLPEDAHRAVASAEETTPGTYRLAVPASRSDVLLRALLTARPPWHVVSVEQRA
                     DTPGSPR"
     gene            2910..3671
                     /locus_tag="SCNRRL3882_RS09260"
                     /old_locus_tag="SCNRRL3882_1837"
     CDS             2910..3671
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657150.1"
                     /locus_tag="SCNRRL3882_RS09260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1837"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_050810166.1"
                     /transl_table=11
                     /translation="MSEDPTPVSDSPFRSGPSARDTAPQFVLPLVVRIERADPPARTDA
                     LETAARAVLTILSDERSAGDGPWAQAVRDWQDARIRKVVRRARGAEWRRAEALPGITVT
                     GKSAEVRVFPPVPLDGWPKDLARLQVSGTDLDDPEPPVDADPAAPVLWLNPDLGMSAGK
                     AMAQAGHAAQLAWWELTDGERAAWHDAGFRLAVRPADPARWPGLTGSGLPVVRDAGFTE
                     IAPGSCTVVADHPALRREPYAPGGPALTRSE"
     gene            3740..4198
                     /locus_tag="SCNRRL3882_RS09265"
                     /old_locus_tag="SCNRRL3882_1838"
     CDS             3740..4198
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993752.1"
                     /locus_tag="SCNRRL3882_RS09265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1838"
                     /product="hypothetical protein"
                     /protein_id="WP_010034057.1"
                     /transl_table=11
                     /translation="MTSAAPPPPAPPAPDRTPGGSGSGGTGDPWATRGLALGGTLMVVY
                     GVFAVLQGITAIADDEVYTSFGEYVFEFDLTAWGWIHLIVGVLAVAAGLGLFTGAAWAR
                     VVGAVVVGLALIANFMWLPYQPFWSIIMIVTGLFVLWSVFNYRSTRAA"
     gene            complement(4212..4799)
                     /locus_tag="SCNRRL3882_RS09270"
                     /old_locus_tag="SCNRRL3882_1839"
     CDS             complement(4212..4799)
                     /GO_function="GO:0005267 - potassium channel activity
                     [Evidence IEA]"
                     /GO_process="GO:0034220 - monoatomic ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568421.1"
                     /locus_tag="SCNRRL3882_RS09270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1839"
                     /product="potassium channel family protein"
                     /protein_id="WP_010034054.1"
                     /transl_table=11
                     /translation="MRDGSEQAHGPARKREQEPQAPAPAPAASRRLWAAAGGLVVAVGT
                     AYFLLPLEGFGDDRSWLGWPLFVLCLGLLGVLLLRQVRDVVLEKPHTRPGVMIPLLMCL
                     AVLVFSSGYYTLAQRPGQFTGLSTRVDALYFTVVTLATVGYGDITPSGQEARLVTVAQI
                     LYTFVFLTAGATALSRRLHTVVAARDRHPPPS"
     gene            5001..6440
                     /locus_tag="SCNRRL3882_RS09275"
                     /old_locus_tag="SCNRRL3882_1840"
     CDS             5001..6440
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993751.1"
                     /locus_tag="SCNRRL3882_RS09275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1840"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_010034053.1"
                     /sec_met_domain="DUF692 (E-value: 6e-97, bitscore: 322.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLGTGIGWRPEIADAVERMPGIDWVETVAENVCPGHLPESLRR
                     LRERGVTVVPHGVSLGLGGADRPDDGRLAALAERVEALGSPLVTEHIAFVRAGGSLTAT
                     PHLEAGHLLPVPRTRDALDVLCENVRIAQEALPVPLAVENIAALIAWPGEEMTEGQFLY
                     ELADRTGVRLLIDVANLHTNHVNRAEDPAKALAELPLEAIAYVHVAGGFERDGVWHDSH
                     AHPVPRPVLDILSDLASRVSPPGVLLERDENFPEPAELEAELASIRRAVEAGAVERVKA
                     EVRAAGNAVAARRQAAAPGGRREVRAEAPVRGEAGAPRCHRTGTAEATRGAFGRPEHRS
                     VDEARQRLGVAQAALLSALVAGTPVPEGFDRVRVGVQARALAAKRADVVGKVAPELPEI
                     LGADYRTAFLGYAQTQPMTGGYRRDALTFAEHLLSAGRPGDAAARRELREWWLERSGPA
                     PRSRRPVRRLARATRKVLLRR"
     gene            complement(6464..7945)
                     /locus_tag="SCNRRL3882_RS09280"
                     /old_locus_tag="SCNRRL3882_1841"
     CDS             complement(6464..7945)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993750.1"
                     /locus_tag="SCNRRL3882_RS09280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1841"
                     /product="amino acid permease"
                     /protein_id="WP_029180759.1"
                     /transl_table=11
                     /translation="MTSPQPPAPAAGAPSAEPGSEFRKDMGPWANFALGFTYLSPVVST
                     YTLFGTAIVDGGPPMIWAFVLAGCGQFLVALIFGEIVAQYPIAGGVYPWARRLWGKRWA
                     WMTGWVYMWALLVTITSVAYGAGPYIAILFGFDTTVHTTVLCTAVLIVIAVLINYMGTK
                     ALSAAAVIGFAGELIGALVVGIYLLSTHRHHGLGVIFDTYGAEGDGSYLPAFLAAAIIG
                     FYQYYGFEACGDTAEEVAHPGRVIPRAMRRTIYIGGAAATFTCMSLLLSVTDFNAVISG
                     EQADPVVDVLYDAMGETGARMVMAVVLISFLSCTISLQAAAGRLIYSYARDEMIAGHRL
                     LRRFAHARAVPGYALFVSAAVPLLIAFASLLSEDALTNIVSFAILGIYGSFQMVVLAAL
                     RARLKGWRPAGEFTLGRWGLTVNVGALAYGIFAIVNICWARSPEKPWYENWIVLLCGAV
                     VVGTGALYMFTTHHYGRGDAPAGDAVPKTGAVSKD"
     gene            complement(7942..9513)
                     /locus_tag="SCNRRL3882_RS09285"
                     /old_locus_tag="SCNRRL3882_1842"
     CDS             complement(7942..9513)
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993749.1"
                     /locus_tag="SCNRRL3882_RS09285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1842"
                     /product="GMC oxidoreductase"
                     /protein_id="WP_010034049.1"
                     /transl_table=11
                     /translation="MAPTIAHGAESAYDYVIVGGGTAGCVLAARLSEDPDCRVCVVEGG
                     PSDIGDERILRLRNWINLLGSEFDYGYTTVEQPRGNSHILHSRARVLGGCSSHNTLISF
                     LPLPQDLDDWVSRGCSGWDPATILPYRDRLLTQIVPVAEADRNPIAQDFVTAASRALGV
                     PVVDDFNAEPFADGTGFFSLAYQPEGNLRSSASVAYLHPVLDRPNLTLLLETWAHRLLP
                     DESGRLTRVAVRGADGEPAAVRAERELLLCAGAIDTPRLLLLSGLGPADDLRALGIGVR
                     ADLPGVGENLLDHPESVIVWETAGPLPPNSAMDSDAGLFLRRDKGQPRPDLMFHFYQVP
                     FTVNTERLGYPVPAYGVCMTPNVPRARSTGRMWLRSNNPAEHPALDFRYFTDAEGHDER
                     TIVDGLKVAREVAATDPLRDWLVREVAPGPDVVSDADLSEYGRRVAHTVYHPAGTCRMG
                     APDDPMAVCDPELRLLGVEGVRIVDASVFPTMPTINPMVTVLLAAERAADLILDRPGPA
                     EQEARQ"
     gene            complement(9596..11062)
                     /locus_tag="SCNRRL3882_RS09290"
                     /old_locus_tag="SCNRRL3882_1843"
     CDS             complement(9596..11062)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034047.1"
                     /locus_tag="SCNRRL3882_RS09290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SCNRRL3882_1843"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_010034047.1"
                     /sec_met_domain="Aldedh (E-value: 3.5e-172, bitscore:
                     572.0, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGELYIDGEWTQAAAGGRREVVNPYDASVVTTVDEADATDVDRAV
                     RAARRAFVEEDWANATSRRRADLLLRVRDLLLRDQEDIARTETLDTGKTLAEARIDVKD
                     VANAFRYFAELAGKDGGRVVDVGPDVLSRVVYQPVGVCALIAPWNYPLLQASWKVAPAL
                     AAGNTFVLKPSETTPLTTIAMIRLIEEAGAPPGVANLVLGSGATVGAALTSHPEVDLVS
                     FTGGLTTGRSIMASAAEGPRNIALELGGKNPNIVFADADFDAAVDYALDAAFLHSGQVC
                     SAGSRLLVQDSLHDRFVEALARRAAAIRLGNGLEEGTESGPLSSAEHREKVERYIAVAQ
                     EEGARLVTGGTRPDDPALSRGFFLLPTIFADCDRSMRIVQEEVFGPVVTVERFGTEDEA
                     VELANDTRYGLAGGVWTSDAGRAQRVAQRLRHGTVWINDFHPYVPQAEWGGFGRSGVGR
                     ELGPTGLREYQEAKHIYQNLAPAPSGWFKG"
     misc_feature    complement(11372..11389)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.76"
                     /tool="antismash"
ORIGIN
        1 ggcgccgtgg tccgcgccga cgggcaccac cgcctcgccg tctaccggga cgacgacggc
       61 aatctgcaca gcgtctccgc ccgctgcacc cacctgggct gcctggtcgc cttcaactcg
      121 gccgaacgcg cctgggagtg cccctgccac ggctcccgct tcgacacgga cggcaaggtg
      181 atccagggcc cggcgaccaa accgctggag cagcgggaca tctgacggcc gggtgatgcc
      241 cgcatccgat acgcataaga ggacgatccc gctcatatct tcatacggtg atcacccttc
      301 tccgccgtgc caccgcggtg tgcgccctga gcacggccct cgcggcgtgc ggggccggcc
      361 gtcccccgca gccgccctcg ccgccggtgt ccgcaccgcc gtcgcgccct ccgaccctcg
      421 cccccggccc caccggcctg accccggtct tcgagcacgg cccccgcacc cgcggcagga
      481 ccgtcgccct caccttcgac gccgacatga ccgccgggca gggggcccgg gcggcggcgg
      541 gtgagcggtt cgaccatccg cggctgatct cgacgctgcg cgcgctgcag gtgcccgcca
      601 ccgtgttcat gaccgggcgg tgggccgagc agtacccgga ccaggcccgt tccatcggcc
      661 gggacccgct gttcgaggtc gccaaccact cctacagcca ctacgcgtac acgccggact
      721 gctacggcct gcccaccgtg cccgaaaagc gcatgcggtc ggacgtggag cgggcgtacg
      781 ccgccctccg gaaggccggt gtgacggatc cgatgccgta cttccgcttc cccggcggct
      841 gttacgaccg gcgggcgctg aaggcgctga caccggccgg tgtgaccgcc gtgcagtggg
      901 acgtggtcgg cggcgacgcg ttcgagacgg acccggaggt ggtcgcccgg caggtgctgg
      961 acggcgtgcg gccggggtcg gtggtcgtgc tgcactgcac gcgcagcgcc gccccggcga
     1021 ccgaacgggc ggtgcgctcg atcgtgccgg ggctgcgccg cgagggcttc cggttcgtga
     1081 aggtgtccga gctgatcggg gcggccggca gcggtgcgcg gacccgcccg gagggacgct
     1141 gaccggccta cgctggacgt atgagcgagg acgactactg cctgatcgac gcgaccaggc
     1201 cgccccgggc ggacggaccg ccgtacgcgg agtgcgtgct gtgccgggag ccgacggagt
     1261 atccggagtc ctacaagggc atcaccctct gccccgtctg tgagtggcag gaggcgcagc
     1321 gcaccgcctg ctcaggttga tctgcgggcg gcgagcgcac cggccagggc cagcgcggcg
     1381 gccgtgacca ggaccgccgc ggccaggggc agcagcggca gcgggacggt gcccgaccgg
     1441 gagccggtca ccagcccctg caccgccgcc tgggccgggg agccggtggc cacgagggac
     1501 agcagcgccg cgagcagcag agccaggacg gcacgggccc gcgaccgcag cagcggccgg
     1561 ctggtgagcg cgccgaccgc cgtgccgagc agggcacagg ccagcgcggc gagcagtccg
     1621 gccccgcacg cgggggcgag cgggaccggg gtgcggtggt ccgaggcgac cggagcgctc
     1681 agcagcgtca cgccgagggc cgcgaccgtg ccgagcgtca ccgcgccgga caacgccacc
     1741 agcaggcagg ccacatgggc acgggcgggc ccgaccgcgg ccgccacaca gccccgcgcg
     1801 gcctgcggct ccgccgtgac acagatccgt gccagccagg cggcgacggg cagcagcgcg
     1861 gcggccgcgt agccgagcga gtcgagcacc ggctgcccgg cctggacgct gatcgcgagg
     1921 aaggcggcgt acagcaggaa cggcgggagc cagcgctggg agcgcagcag cagggcggcg
     1981 tggtagccca tcagggcggt catcgggggc tccccggggt gtccgcccgc tgctccacgc
     2041 tcaccacgtg ccagggcggg cgggccgtca gcagggcgcg gagcaggacg tcggagcggg
     2101 aggcggggac ggcgaggcgg taggtgcccg gcgtggtctc ctcggccgag gcgaccgccc
     2161 ggtgcgcgtc ctcgggcagc cgcccgtccg gcgggccctg cgccacgacg gtgacgtgcg
     2221 ggccggacgg gccggacccc ggcgccgcac acgggacgag gctcccgtcg cgtacggcgt
     2281 acgtcgcgtc gggcaggccc gcgaggcggc gcgggtcgtg gtcgacgaac accacggacc
     2341 cgccggccgc cgtgcgctcg gcgaccgccc gctccaactc ggcgcgggcg tcggtgtcga
     2401 ggcccgtcca cgcctcgtcc agcaccagca gctcgggctc cgccagcagg gcctgggcga
     2461 ccgcgatctt ctggctggtg cccttcgaca gccgcgccat cggcgtcccg gcgtacgcgg
     2521 cggcgccgag gcgctccagc cactcgccgg cggcgcgggc ggccgccgta cgggtcaggc
     2581 cgtgcacggc gccgaggtgg gtgagatagc cgacggcggt gaacggcagg gccggcggga
     2641 accgctcggg gacgtaggcg gtgcgcgggc ggccggtgat ccggccctcg ctgggggcgt
     2701 cgatgccggc gagcagccgc aggagggtcg acttgccggt gccgttggcg ccctcgacgc
     2761 ggacgagccg gcccggggcc accgtcaggt cgacgccgcg cagcacccag gggccgcgca
     2821 ggccgtagcg gcggcccgcg ttctgcaggc acaggtcggg tcgcatgggc cccatcctcc
     2881 acgatcttcc ggctggcaca ctgggattcg tgagcgaaga cccgacgccc gtgagtgaca
     2941 gccccttccg gtccggaccc tcggcccgcg acacggcacc gcagttcgtg ctgccgctgg
     3001 tcgtgcggat cgagcgggcg gacccgccgg cgcggacgga cgcgctggag acggccgcgc
     3061 gcgccgtgct gacgatcctc agcgacgagc ggtcggccgg cgacggcccg tgggcgcagg
     3121 ccgtgcggga ctggcaggac gccaggatcc gcaaggtcgt gcggcgggcg cgcggcgccg
     3181 agtggcggcg ggcggaggcg ctgcccggca tcaccgtcac cggcaagtcg gccgaggtgc
     3241 gggtcttccc gccggtcccg ctcgacggct ggcccaagga cctggcccgg ctccaggtct
     3301 ccggcaccga cctggacgac ccggaaccgc cggtggacgc ggacccggcc gcccccgtgc
     3361 tgtggctgaa ccccgacctc ggcatgtcgg ccggcaaggc gatggcccag gccggccacg
     3421 ccgcgcaact ggcctggtgg gagctgaccg acggggagcg ggccgcctgg cacgacgcgg
     3481 gcttccggct cgccgtgcgg ccggccgacc cggcgcgctg gcccgggctg acgggcagcg
     3541 gcctgccggt ggtccgcgac gcggggttca cggagatcgc gcccggctcg tgcaccgtgg
     3601 tcgcggacca cccggcgctg cgccgggagc cctacgcgcc gggcggcccg gcgctcaccc
     3661 gttcggagta gccgcaggcg cgccgctcct gggcgggtgc tccagtgggg ttaccggaca
     3721 accccaccag gaggcagcca tgaccagcgc cgcgccccct ccccccgccc cgcccgcccc
     3781 cgaccggacg cccggcgggt ccggctccgg cggtacgggc gatccctggg cgaccagggg
     3841 tctcgctctc ggcggcaccc tgatggtcgt ctacggcgtg ttcgcggtgc tccagggcat
     3901 cacggcgatc gccgacgacg aggtgtacac gagcttcggc gagtacgtct tcgagttcga
     3961 cctgaccgcg tggggctgga tccacctgat cgtcggggtg ctcgcggtgg cggccgggct
     4021 cggcctgttc accggggccg cctgggcccg ggtcgtgggc gcggtcgtgg tcgggctggc
     4081 gctgatcgcg aacttcatgt ggctgccgta ccagccgttc tggtcgatca tcatgatcgt
     4141 gaccggcctc ttcgtgctgt ggtcggtgtt caactaccgc tccacccgcg cggcgtagag
     4201 gccgacccgg ttcaggaggg cggcgggtgc cggtcgcgcg cggcgaccac cgtgtgcaga
     4261 cggcgcgaga gcgcggtggc acccgccgtg aggaagacga acgtgtacag gatctgggcg
     4321 acggtcacca ggcgggcctc ctgcccgctc ggggtgatgt cgccgtagcc gacggtcgcg
     4381 agcgtgacga cggtgaagta cagcgcgtcg acgcgggtgc tcaggccggt gaactggccc
     4441 ggccgctggg cgagggtgta gtaccccgac gagaagacca gcacggccag gcacatcagc
     4501 agcgggatca tgacgccggg ccgggtgtgc ggcttctcca gcacgacgtc gcgcacctgg
     4561 cgcagcagca gcacgcccag cagccccaga cacaggacga aaagcggcca gcccagccag
     4621 gagcggtcgt cgccgaaccc ctccagcggc agcaggaaat aggccgtgcc gacggcgacc
     4681 acgagtcccc cggcggcggc ccacaaccgc cgggaggccg ccggggcggg ggccggggcc
     4741 tgtggctcct gttcccgctt ccgcgcgggg ccgtgcgcct gctcgctgcc atcgcgcata
     4801 cgtccggtct acgacgtatc gggaggtggc gcgaccctgg tgcctccgtc ggtgggcccg
     4861 ggacgtcggt cgggagcccg ggccgccggg ggccgaacct caaatgttcc tctgaaggcg
     4921 tccgtggcgg ggttcggggg cgggcggctg ggccataccc ccctcacgtt cgaggaaccg
     4981 gctgtgcgga ggaggggacg atgaagcgac tggggacggg catcgggtgg cgaccggaga
     5041 tcgcggacgc cgtggagcgc atgccgggca tcgactgggt cgagaccgtg gccgagaacg
     5101 tctgccccgg gcatctgccc gagtcgctgc ggcggctgcg cgagcgcggc gtcaccgtgg
     5161 tgccgcacgg cgtctcgctc ggcctcgggg gtgcggaccg gcccgacgac ggccgtctgg
     5221 ccgcgctggc cgagcgggtg gaggcactcg gctcaccgct ggtcaccgag cacatcgcgt
     5281 tcgtccgggc cggtggttcg ctgacggcga ctccgcacct ggaggcgggc catctgctgc
     5341 ccgtcccccg gacccgggac gcgctcgacg tgctgtgcga gaacgtgcgc atcgcgcagg
     5401 aggcgcttcc ggtgccgctg gccgtcgaga acatcgccgc actgatcgcc tggccgggcg
     5461 aggagatgac ggagggccag ttcctctacg agctcgccga ccgcacgggc gtccggctcc
     5521 tcatcgacgt ggccaacctg cacaccaacc acgtcaaccg cgccgaggac ccggccaagg
     5581 ccctcgccga gctgcccctg gaggccatcg cctacgtcca tgtcgccggc ggtttcgaac
     5641 gcgacggcgt ctggcacgac agccacgccc accccgtccc ccggccggtc ctcgacatcc
     5701 tgagcgacct cgcgtcccgc gtgtcccctc cgggggtcct gctggaacgc gacgagaact
     5761 tcccggaacc ggcggagctg gaggccgagt tggcctccat ccggcgggct gtggaggcgg
     5821 gggccgtcga gcgggtgaag gccgaggtgc gcgcggcggg caacgcggtc gcggcgcggc
     5881 ggcaggcggc cgcgcccgga ggccggcgcg aggtccgcgc cgaggccccc gtgcgcggcg
     5941 aggccggggc gccgcggtgc catcggaccg ggacggccga ggcgacacgg ggcgccttcg
     6001 gccggcccga acaccggagc gtcgacgagg cccggcagcg gctcggggtc gcgcaggccg
     6061 cgctgctgtc ggcgctggtc gcggggacgc ccgtgcccga ggggttcgac cgggtgcggg
     6121 tcggcgtaca ggcacgggcg ctcgccgcga agcgggcgga cgtcgtgggc aaggtcgcac
     6181 cggaactgcc ggagatcctc ggggcggact accgtacggc cttcctcggg tacgcccaga
     6241 cgcagccgat gaccggcggc taccggcgcg acgcgctcac cttcgccgag cacctgctgt
     6301 ccgccgggcg gcccggggac gccgctgcgc ggcgggagct gcgggagtgg tggctggagc
     6361 ggtcggggcc ggcgccgcga tcgcggcgcc cggtccgccg gctggcccgc gccacccgga
     6421 aggtgctgct gcggcgttga cgcgggggcc gcccgtccgc tcgtcagtcc ttcgacacgg
     6481 ccccggtctt cggcacggcg tcaccggcgg gtgcgtcgcc gcggccgtag tggtgagtgg
     6541 tgaacatgta cagcgcgccg gtaccgacca ccaccgcgcc gcacagcagg acgatccagt
     6601 tctcgtacca cggcttctcc gggctgcggg cccagcagat gttgacgatg gcgaagatgc
     6661 cgtaggccag cgccccgacg ttcaccgtga ggccccagcg gcccagggtg aactcccccg
     6721 ccgggcgcca ccccttgagc cgggcgcgca gcgcggccag caccaccatc tggaacgagc
     6781 cgtagatacc gaggatcgcg aacgacacga tgttggtgag ggcgtcctcg gagagcagcg
     6841 aggcgaaggc gatgagcagc ggtaccgccg cggacacgaa cagcgcgtag ccgggcaccg
     6901 cgcgggcgtg ggcgaaccgc cgcagcagcc ggtgcccggc gatcatctcg tcacgggcgt
     6961 aggagtagat gagccgcccg gccgcggcct ggaggctgat cgtgcaggac aggaaggaga
     7021 tcagcaccac ggccatcacc atccgcgccc cggtctcgcc catggcgtcg tacagcacgt
     7081 ccaccacggg gtcggcctgc tcgcccgaga tgaccgcgtt gaagtccgtg accgacagca
     7141 gcagcgacat gcaggtgaac gtggccgcgg caccgccgat gtagatggtg cggcgcatcg
     7201 cgcgcgggat gacacggccc gggtgggcga cctcctcggc cgtgtcgccg cacgcctcga
     7261 agccgtagta ctggtagaag ccgatgatcg cggcggcgag gaacgcgggc aggtaggagc
     7321 cgtccccctc ggcgccgtac gtgtcgaaga tgacgccgag gccgtggtgc cggtgggtgg
     7381 acagcaggta gatgccgacg acgagggcgc cgatgagctc accggcgaag ccgatgacgg
     7441 ccgccgccga cagcgccttg gtccccatgt agttgatgag gacggcgatg acgatcagca
     7501 ctgcggtgca cagcacggtg gtgtgcacgg tggtgtcgaa gccgaagagg atggcgatgt
     7561 aggggccggc gccgtaggcg acggaggtga tggtcaccag cagcgcccac atgtacaccc
     7621 agccggtcat ccacgcccag cgcttgcccc acaggcgccg ggcccagggg tagacgccgc
     7681 ccgcgatggg gtactgggcg acgatctcgc cgaagatcag cgcgacgagg aactgtccgc
     7741 agccggccag cacgaacgcc cagatcatcg gcggtccgcc gtcgacgatc gcggtgccga
     7801 agagggtgta ggtgctcacc accggggaca ggtaggtgaa gccgagggcg aagttggccc
     7861 aggggcccat gtccttgcgg aactccgagc cgggctctgc cgagggagcc ccggccgccg
     7921 gagcgggggg ctgcggactg gtcactgtcg ggcctcctgt tccgcggggc cggggcggtc
     7981 gaggatcaga tcggcggcgc gttcggcggc gagcaggacg gtcaccatcg ggttgatggt
     8041 gggcatcgtc gggaacaccg acgcgtcgac gatccgcacg ccctcgacgc cgagcagtct
     8101 caactccggg tcgcagacgg ccatcgggtc gtccggggcg cccatgcggc aggtgcccgc
     8161 cgggtggtag acggtgtgcg ccacgcggcg gccgtactcg gagaggtcgg cgtcggagac
     8221 gacgtccggg ccgggcgcga cctcgcggac gagccagtcg cgcagcgggt cggtggcggc
     8281 gacctcgcgg gcgaccttca gcccgtccac gatggtgcgc tcgtcgtgcc cctcggcgtc
     8341 ggtgaagtac ctgaagtcca gggcgggatg ctcggcgggg ttgttgctgc gcagccacat
     8401 gcggccggtg gagcgggcgc gcggcacgtt cggcgtcatg cacaccccgt aggccggcac
     8461 cgggtagccc aggcgctcgg tgttgacggt gaacggcacc tggtagaagt ggaacatcag
     8521 gtcggggcgc ggctggccct tgtcgcggcg caggaacagg ccggcgtcgg agtccatcgc
     8581 ggagttgggc ggcagcggcc ccgcggtctc ccagacgatc acggactcgg ggtggtccag
     8641 caggttctcg cccacgccgg gcaggtcggc ccgtacgccg atgcccaggg cgcgcaggtc
     8701 gtcggccggg ccgaggccgg agagcagcag caggcgcggg gtgtcgatcg cgcccgcgca
     8761 cagcaggagt tcgcgctcgg cacgcacggc ggcgggttcg ccgtcggcgc cccggacggc
     8821 gacgcgggtc agccggcccg actcgtccgg gagcagccgg tgcgcccagg tctccagcag
     8881 gagcgtcagg ttgggccggt ccaggacggg gtggaggtag gcgacggacg cggaggagcg
     8941 caggttgccc tccggctggt aggccagcga gaagaagccg gtgccgtcgg cgaagggttc
     9001 ggcgttgaag tcgtcgacga cggggacgcc gagggcgcgg gaggccgcgg tgacgaagtc
     9061 ctgggcgatg ggattgcggt cggcctcggc gaccgggacg atctgtgtga gcagccggtc
     9121 gcggtagggg aggatcgttg ccgggtccca gccggagcag ccccggctca cccagtcgtc
     9181 gaggtcctga ggcagcggca ggaagctgat cagcgtgttg tgcgaggagc agccgccgag
     9241 gactcgggcc cgtgagtgca ggatgtggga gttgccacgc ggctgttcga cggtggtgta
     9301 gccgtagtcg aactccgagc cgagcaggtt gatccagttg cgcaggcgca ggatgcgctc
     9361 gtcgccgatg tcgctggggc cgccctcgac gacgcagacg cggcagtcgg ggtcctcgct
     9421 caggcgggcg gcgagcacgc agccggcggt gccgccgccg acgatgacgt agtcgtaggc
     9481 cgactcggcg ccgtgcgcga tggtgggggc catgcggtgc cctgctttct gtgtcgttcg
     9541 ttgcgtcacg gggtcgttcc ctgcgccacg ggcgggcggt gtgccgcgga ggggttcagc
     9601 ccttgaacca gcccgagggg gcgggggcga ggttctggta gatgtgcttg gcctcctggt
     9661 actcccgcag cccggtggga cccagttcgc gcccgacgcc ggagcggccg aagccgcccc
     9721 actcggcctg cggcacgtag gggtggaagt cgttgatcca gacggtgccg tgccgcagcc
     9781 gctgggcgac gcgctgggcg cggccggcgt cggaggtcca caccccgccg gccaggccgt
     9841 agcgtgtgtc gttggccagt tccaccgcct cgtcctcggt gccgaagcgc tcgacggtga
     9901 ccaccgggcc gaagacctcc tcctggacga tccgcatcga ccggtcgcag tcggcgaaga
     9961 tcgtcggcag caggaagaag ccgcggctca gggcggggtc gtcggggcgg gtgccgccgg
    10021 tcacgagccg ggcgccctcc tcctgggcga cggcgatgta gcgctcgacc ttctcgcggt
    10081 gctcggcgga gctgagcggg ccgctctcgg tgccctcctc caggccgttg ccgagccgga
    10141 tcgccgccgc gcggcgggcg agggcctcga cgaaccggtc gtgcagggag tcctggacca
    10201 gcaggcgcga accggccgag cagacctgcc cggagtgcag gaaggcggcg tccagcgcgt
    10261 agtccacggc ggcgtcgaag tcggcgtccg cgaagacgat gttggggttc ttgccgccga
    10321 gttcgagggc gatgttgcgc ggtccctcgg ctgcgctggc catgatggag cgcccggtgg
    10381 tcagaccgcc ggtgaaggac accaggtcga cctcggggtg gctggtcagg gccgcgccga
    10441 cggtcgcccc ggagcccagc accaggttgg cgacgccggg cggcgcgccg gcctcctcga
    10501 tgagccggat catggcgatc gtggtgagcg gtgtggtctc gctgggcttg aggacgaagg
    10561 tgttgccggc ggccagcgcc ggagccacct tccaggaggc ctggagcagc gggtagttcc
    10621 agggggcgat gagcgcgcag accccgaccg gctggtagac gacgcggctg aggacgtccg
    10681 ggccgacgtc cacgacccgg ccgccgtcct tgcccgcgag ttcggcgaag tagcggaagg
    10741 cgttcgccac gtccttcacg tcgatgcggg cctcggccag cgtcttgccg gtgtcgaggg
    10801 tctcggtgcg ggcgatgtcc tcctggtcgc gcagcagcag gtcacgcacg cgcagcagga
    10861 ggtcggcccg gcggcgggag gtggcgttgg cccagtcctc ctcgacgaag gcgcgccggg
    10921 cggcgcgtac ggcgcggtcc acgtcggtgg cgtcggcctc gtcgacggtg gtgacgacgg
    10981 aggcgtcgta ggggttgacc acctcccgcc ggccaccggc cgccgcctgt gtccactcgc
    11041 cgtcgatgta cagctcgccc accgcggggc ctccttcgca tccggccggt gccgatcggc
    11101 tcgacggtca gcaacatggc ccatcgggcg ggcggcggcc acgggccaca ccgccgcgac
    11161 ggcgtcccgg tgacccagag gacccgggtg ggctagtccc ccgcctcacc cgtccgcgcg
    11221 cgagtgtgcc cgacctgaca cccgggtccc gcccgcctgg agccatggat tgttttgcgc
    11281 ctctttgccc cggcgagtcc cccgtcgcgc ctcctccaat cgtcccgtgc tgcccccgtt
    11341 gcaaccattc gtccctgtac ggcagttgac gtagacgccg cagtaacatg caactccgca
    11401 cccgaagcgc actagcgtgc ggtgccgtac caggaggcac
//
