LOCUS       NZ_LT907981            10228 bp    DNA     circular CON 12-FEB-2024
DEFINITION  Streptomyces sp. 2323.1 chromosome I.
ACCESSION   NZ_LT907981
VERSION     NZ_LT907981.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 2323.1
  ORGANISM  Streptomyces sp. 2323.1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 03:31:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,058
            CDSs (total)                      :: 6,971
            Genes (coding)                    :: 6,808
            CDSs (with protein)               :: 6,808
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 163
            CDSs (without protein)            :: 163
            Pseudo Genes (ambiguous residues) :: 0 of 163
            Pseudo Genes (frameshifted)       :: 64 of 163
            Pseudo Genes (incomplete)         :: 123 of 163
            Pseudo Genes (internal stop)      :: 17 of 163
            Pseudo Genes (multiple problems)  :: 37 of 163
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7324049
            Orig. end                         :: 7334277
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT907981.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10228
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="31"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10228
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10228
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5228](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5228
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            750..1658
                     /locus_tag="CPH93_RS31690"
                     /old_locus_tag="SAMN06272775_6442"
     CDS             750..1658
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091736.1"
                     /locus_tag="CPH93_RS31690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_6442"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_096214786.1"
                     /transl_table=11
                     /translation="MIEARRLHILRAVADHRTVTAAAAALYLTPSAVSQQLAALEQETG
                     HRLVERSARGVRLTAAGDILLTHANAVLAQLERAESELAAYGSGEAGTVTVAAFATGIG
                     LVVAPALTALARTAPGIRVRVQDAEGDASLLMVLDRQVDVAVAVEYRGAPRADDPRLTR
                     VPLYAEPFDAVLPPGHRLAEATQVAVADLAGDPWIGPYPGNPCHDVVVLACEYAGFEPR
                     LEHSSDDFRAVVSLASAAAGVALVPRSALRDMDLTGVVVRPVDGVAPTRRVFAAVRRGA
                     EDHPLLRPVLAALREAAAPQG"
     misc_feature    769..785
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     gene            1818..3200
                     /locus_tag="CPH93_RS31695"
                     /old_locus_tag="SAMN06272775_6443"
     CDS             1818..3200
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606562.1"
                     /locus_tag="CPH93_RS31695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_6443"
                     /product="chloride channel protein"
                     /protein_id="WP_096214787.1"
                     /transl_table=11
                     /translation="MSVGPAGPVGPAQAGVPQDPYAPVRGRGYLKLLLVAAVVGFPVCA
                     LAFGFLALVHVLEPLLYSDLPRALGFAGTPLWWPVPLLVVAGLLVGLTVRHLPGHGGHE
                     PADGLSLSGAPPLSALPGVVLAALASLSFGVVLGPEAPLIALGGGLAAGALRLLRRGVP
                     DQAAAAVGAAGSFAAVSALLGSPLLGAFLLMEVSGLGGPMLGIVLVPGLLAAGIGALVF
                     TGLGDWTGLGTYSLALHDIPKAAGPTVPEFGWALVIGVLAALAATGVRRLAVFLKGHVV
                     RHRVPATMLMGLVVGALAVAFAAATGKSATEMLYSGQSALGSLFHDSAGYTVTALLMLI
                     LCKGLAYCASLSAFRGGPIFPALFLGAAGGVVLSHLPGLSLTAAFAMGVGAMCVAMLKL
                     PMTSVLLATLLLGYSGLTVMPLVIVAVVVSYVVALRLTPAPAESAPAPARPAPPETAPG
                     TP"
     gene            complement(3213..4244)
                     /locus_tag="CPH93_RS31700"
                     /old_locus_tag="SAMN06272775_6444"
     CDS             complement(3213..4244)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606563.1"
                     /locus_tag="CPH93_RS31700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_6444"
                     /product="PHP domain-containing protein"
                     /protein_id="WP_096214788.1"
                     /transl_table=11
                     /translation="MEPVEALERIAFLLERQGAVPYRVQAFRTAAAVIGALPRDELHQR
                     ARNSSLGRLKGLGPKTTRVVEEALAGVRPVYLAHLEEEAGGPLVDGEQGQRLRRALRGD
                     CHLHSDWSDGGSPVETMARAARDLGHEWCVLTDHSPRLTVARGLTAERLRQQLSLVAEV
                     NEQLAPFRLLTGIECDILDDGSLDQEPELLEQLDVVVASVHSKLRMDEGPMTRRLLAAV
                     RNPLVDVLGHCTGRQITGKPRPESRFDAGEVFAACAEQHTAVEINCRPDRLDPPRRLLR
                     QALAAGCLFSVDSDAHAPGQLDWQIYGCARAEECGVPADRIITTWTERQLATWTRTGRT
                     PRR"
     misc_feature    complement(4440..4455)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.76"
                     /tool="antismash"
     misc_feature    4778..4791
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.87"
                     /tool="antismash"
     misc_feature    4968..4981
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.07"
                     /tool="antismash"
     gene            5001..5228
                     /locus_tag="CPH93_RS31705"
                     /old_locus_tag="SAMN06272775_6445"
     CDS             5001..5228
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="CPH93_RS31705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_6445"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_093481848.1"
                     /sec_met_domain="strepbact (E-value: 7.7e-32, bitscore:
                     108.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVQTQEISDSDLDNVSGGLLGNAVGTAASTVDSIAPVSGA
                     VGTATGLVDGATGVNTSGVVGTATGLVSGL"
     misc_feature    complement(5266..5278)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.5"
                     /tool="antismash"
     gene            5402..6208
                     /locus_tag="CPH93_RS31710"
                     /old_locus_tag="SAMN06272775_6446"
     CDS             5402..6208
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="CPH93_RS31710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_6446"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_096214789.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPEEIDLPVRFARPQGWLVLTVTVLFVFAASVW
                     AVTGTVSSTLNAPGILTHGQGSYVLQSPVAGQVTAVLAEEGKRVAANTPILKVRTPRGS
                     TVVRALAAGRLTTMSATIGAVVTTGAEVASVERVAHDRDPLTAMLYVPAQSGATVPVGA
                     SVDLTVQSVPSQQYGVLRGRVKAVGRTAQTRQRISTFLGSSQLGEQFSRHGQPVAVLVQ
                     LDPAPHNRSGYAWSTSDGPPYAVDSMTLADGAVHLAAQHPIDWLLP"
     gene            6205..8493
                     /locus_tag="CPH93_RS31715"
                     /old_locus_tag="SAMN06272775_6447"
     CDS             6205..8493
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006606566.1"
                     /locus_tag="CPH93_RS31715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_6447"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_096214790.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 6e-38, bitscore:
                     128.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPHDSAAPQPQLPPPGRGRHRPEAGPGARRTRRAAPPAPKPKK
                     TRAVRTPTVLQMEAVECGAASLAMVLAHYGRHVPLEELRIACGVSRDGSRASNLLKAAR
                     SYGLQAKGMQMEPAALAEVQAPAILFWEFNHYVVYDGTARRFGRRGVHINDPDKGRRFV
                     ATEDFDTSFTGVALVFEPGEDFRKGGRKPGILSAVPARMRGTTGTLLAALLASLLLVAV
                     GAAVPALSRTYIDMFLIGNQTSLLGPLFASMAAMVALTAVLTGLQQANLLRGRIISSTL
                     TSARFLRHLLRLPVTFFAQRSPADLVQRLQSNDAVAETLARDLAAAAVDGVVVILYAFL
                     LWTYDPQLTVIGVGIALLNVVAMRIVVRLRATHTQKLRADTARLTNTAYTGLQLIETMK
                     ATGGENGYFRRWAGQHATTLEEQQRLGVPSAWLAVVAPTLATLNSALILWIGGLRAVEG
                     HISIGLLVAFQALVTRFTAPITRLNGVAGRIQDFAADVARLKDVESFPADTLYSRPGPD
                     SDTRRLKGHVTLEDITFGYSPLDKPLLTGFSLAVGPGRQVALVGGSGSGKSTVSRLISG
                     LYSPWEGAIRIDGQRLEDLSRSALAASVSFVDQDIFLFEGTVRDNVALWDPSIPDDAVI
                     TALKDAALYDDVIARRPDGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTS
                     ALDARTEQIIMDNLRRRGCACVIIAHRLSTVRDSDEIVVLDHGVVVERGRHEHLVAAGG
                     PYAELVKEH"
     misc_feature    10145..10157
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    10171..10186
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.98"
                     /tool="antismash"
ORIGIN
        1 ctggccgacc tggagcgcca gctgaaggag gccgggaacg ccggccgcaa gctggtcgtc
       61 accgacggcg tcttctccat ggacggctat gtggcaccgc tgcgggagat ctgcgacctg
      121 gccgagcagc acggcgccat ggtgatggtc gacgactcgc acgccgtcgg cttcgtcggc
      181 cccggcggcc gcggcacccc cgaactccac gacgtcatgg accgcgtcga catcatcacc
      241 ggcaccctcg gcaaggccct cggcggcgcc tccggcggct atgtcgcggc ccgcgctgag
      301 atcgtcgccc tgctgcgcca gcgctcgcgc ccgtacctct tctccaactc gctcgccccg
      361 gtgatcgccg ccgcctcact gaaggtgctc gacctgctgg agtcggccgg cgagctgcgc
      421 gagcggctgc acgccaacac cgcgctgttc cgctcccgga tgaccgagga gggcttcgac
      481 gtcctccccg gcgaccatgc catcgccccc gtcatgatcg gtgacgcggc cgaggcggcc
      541 cggatggcgg agctgctcct ggagcgcggg gtctacgtca tcggcttctc ctaccccgtg
      601 gtcccgcagg gccaggcacg gatccgggtc cagctgtccg ccgcgcactc caccgaggac
      661 gtcaaccgcg cggtcgacgc cttcatcgat gcgagggccg cgctcggcgg ctgacgcggc
      721 ccgcgggccg ctcctgcgaa aatggaagca tgatcgaagc acgacggctg cacatcctcc
      781 gtgcggtggc cgaccaccgc acggtcaccg ccgcggccgc cgcgctctat ctcaccccct
      841 cggcggtctc ccagcagctg gccgccctgg aacaggagac cggccaccga ctggtggagc
      901 gcagcgcccg cggcgtgcgg ctgaccgccg cgggcgacat cctgctcacc cacgccaacg
      961 ccgtcctggc acagctggag cgcgccgagt ccgagctcgc cgcctacggc tcgggcgagg
     1021 cgggcacggt gaccgtcgcg gccttcgcca ccggcatcgg cctggtcgtc gcacccgcgc
     1081 tcaccgcgct ggcccgtacc gcccccggca tccgggtccg cgtccaggac gccgagggcg
     1141 acgccagcct gctgatggtc ctcgaccggc aggtcgatgt ggcggtggcc gtggaatacc
     1201 ggggcgcgcc ccgcgccgac gacccgcggc tgacccgcgt cccgctctac gccgagccgt
     1261 tcgacgcggt cctgccgccc ggccaccggc tcgcggaggc gacccaggtg gccgtggccg
     1321 atctggcggg cgacccctgg atcggcccct accccggcaa cccctgccat gacgtggtcg
     1381 tcctggcctg cgaatacgcc ggtttcgagc cgcggctgga gcactcctcc gacgacttcc
     1441 gcgccgtcgt ctcgctcgcc tcggccgcgg cgggggtggc cctcgtcccc cgctcggcgc
     1501 tgcgcgacat ggacctcacg ggcgtggtgg tccgtcccgt cgacggcgtg gcccccaccc
     1561 gacgggtctt cgccgcggta cgccgcggag ccgaggacca ccccctgctc cgcccggtcc
     1621 tggccgccct gcgggaggcg gcggcgccgc aggggtgagg gggcggccgc cgcgcgccgc
     1681 gcggccgtac ggacggctcc cgtccggcac ctagccggcc gcgccggaca tgccgacccg
     1741 gaccgcccgt ggcaggctcg tcacggcggc ggcccgggcg ggcgccgggc agccccggtt
     1801 ccgaggaggc gaggcggatg tcggtcggtc cggccggccc ggtcggccca gcgcaggccg
     1861 gcgtgccgca ggacccgtac gcgccggtgc gcggccgcgg atatctcaag ctcctgctgg
     1921 tggcggcggt ggtcggcttc ccggtctgcg ccctcgcctt cggcttcctc gcgctggtcc
     1981 acgtactgga accgctgctc tacagcgacc tgccgcgggc gctcggcttc gccggaacgc
     2041 cgctctggtg gccggtcccg ctgctcgtgg tggccggtct cctggtcggg ctgaccgtcc
     2101 gtcatctgcc gggccatggc ggccacgaac cggcggacgg gctgtcgctc agcggcgcgc
     2161 ccccgctctc cgcgcttccc ggtgtcgtgc tcgcggccct ggcctccctc agcttcggtg
     2221 tggtgctcgg ccccgaggcg ccgctgatcg ccctcggcgg cggcctggcc gcgggcgccc
     2281 tacggctgct gcgccggggg gtgcccgacc aggcggccgc cgcggtgggc gccgccggca
     2341 gcttcgccgc ggtcagcgca ctgctcggct cgccgctcct gggcgcgttc ctcctgatgg
     2401 aggtgtcggg gctgggcggc ccgatgctgg ggatcgtgct ggtgcccggc ctgctcgcgg
     2461 ccgggatcgg tgcgctcgtc ttcaccgggc tgggggactg gaccggcctg ggcacgtact
     2521 cgctcgcgct gcacgacatc cccaaggccg cggggccgac ggtcccggag ttcggctggg
     2581 cgctggtcat cggcgtgctc gcggcgttgg cggcgaccgg tgtacggcgg ctcgcggtgt
     2641 tcctcaaggg ccatgtcgtc cgccatcgcg tcccggcgac gatgctgatg ggactggtgg
     2701 tgggtgccct ggcggtggcc ttcgccgcgg ccaccggcaa gtccgccacc gagatgctct
     2761 attcgggcca gtcggcgctg ggctcgctgt tccatgacag tgccggctac acggtgacgg
     2821 cgctgctgat gctgattctc tgcaagggcc tggcgtactg cgcgtcgctg agtgcctttc
     2881 gaggcggccc gatctttccc gcgctgttcc tcggtgcggc gggcggtgtc gtgctgtccc
     2941 atctgcccgg cctgtcgctc accgctgcct tcgcgatggg cgtcggcgcg atgtgcgtcg
     3001 cgatgctcaa gctcccgatg acctcggtgc tgctggccac cttgctgctg ggatacagcg
     3061 gtctgaccgt gatgccgctg gtcatcgtcg ccgtggtcgt ctcctatgtg gtggcgctgc
     3121 ggctcactcc ggcccccgcg gaaagcgccc ccgcgcccgc acgcccggca ccgcctgaga
     3181 ccgcaccggg caccccctga cccctcgccc gctcagcggc gcggggtccg gcccgtccgg
     3241 gtccaggtgg ccaactggcg ctccgtccag gtggtgatga tgcggtccgc cggtacgccg
     3301 cactcctcgg cgcgggcaca gccgtagatc tgccagtcca gctggccggg ggcgtgggcg
     3361 tcgctgtcga cggagaacag gcagccggcc gccagcgcct ggcggagcag ccggcgcggg
     3421 ggatcgagac ggtccggacg gcagttgatc tccaccgcgg tgtgctgctc ggcgcaggcc
     3481 gcgaacacct ccccggcgtc gaagcgggac tccgggcgcg gcttgccggt gatctgccgc
     3541 ccggtgcagt gcccgaggac gtccacgagg ggattgcgga ccgcggcgag caggcgccgg
     3601 gtcatcgggc cttcgtccat ccggagcttg gagtgcaccg aggcgaccac cacgtcgagc
     3661 tgctccagca actccggctc ctggtcgagc gagccgtcgt cgaggatgtc gcactcgatg
     3721 ccggtcagca gccggaacgg cgccagctgc tcgttcacct ccgccaccag cgacagctgc
     3781 tggcgcagcc gttcggcggt cagcccgcgg gcgacggtga gccgggggga gtggtcggtc
     3841 agcacacacc actcatggcc gaggtcgcgg gcggcacgcg ccatcgtctc gaccggactg
     3901 cccccgtccg accagtccga gtgcagatgg cagtctccgc gcagcgcccg ccgcagccgc
     3961 tgcccctgct ccccgtcgac cagcgggccg cccgcctcct cctccaggtg tgccagatac
     4021 acgggccgca cgcccgcgag cgcctcctcg accacccggg tggtcttggg gcccagcccc
     4081 ttgagccgtc ccagggagct gttgcgggcg cgctggtgca gctcgtcgcg gggcagtgcg
     4141 ccgatgacgg ctgcggccgt acggaacgcc tggacgcggt agggcaccgc accctgccgc
     4201 tccagcagaa aggcgatccg ctccagcgcc tcgacgggtt ccacgcgcgg ctccttcccg
     4261 gggcgccggc cccgcagcgt tctttcacgg tgccgcaccc ggtgggcgac ggccaccggg
     4321 gtgccggtgt tgtcggcggt agccgcgtat taccgccgag tccgaagccc cgctgttatg
     4381 cggttatgtc cgttctccgg tcactcgatc cctttccatg cgaatagcat gaggagggtg
     4441 ctgatgattc ccttccatgc tttctgtgta tgcaattggg tccaataagt ccgggcgaat
     4501 cggtcacagt tcatgatcgt gcaacattca tggcggtgtg ccggaagcgt gtgccggagt
     4561 tccgcgaccc tgtcgcggcc gggtgccgga aaaactgaag gtcttcaaag gatctgcaca
     4621 gcgattgcgc agtcggcaca gcctctccgg tgtcgcgtca ccccgctgac ctgcgcataa
     4681 gcggtttggt gcgggaatgt cctgttcgtc gaacgagaca ttgccggggt gcccgaaagg
     4741 aaaccgaaga ggatgtgaag aagctgccac caagtcatgg atgcccgtgc acgtcaggta
     4801 attcgacggg gcgttggcat ccggatcagc ggccgtccga ttagcagcgc aacccgcccg
     4861 catgctttga tccttcgcac tgcgggagtc acaccatcgg ttcccgattt cgggtacccg
     4921 actgccgctg cgcgcccgga ccaccccacc ggacggtacg gacgcagctt tttagagata
     4981 ttcatccgaa gggaaacatc atgaactcca ccccccaggt ccagacccag gaaatctccg
     5041 acagcgacct ggacaacgtg tccggtggcc tcctcggcaa cgcggtcggc accgccgcca
     5101 gcaccgttga cagcatcgcc ccggtctcgg gcgccgtcgg caccgcgacc ggcctggtcg
     5161 acggcgccac cggcgtcaac acctccggcg ttgtgggcac cgcgaccggc ctggtctcgg
     5221 gtctctgaga cccttctgtg ccgctagcgg cacagtcggc tcaaggtgac aacggcaggt
     5281 cggcgtcccc tccttgccga catgtcgcgc caggtgcccc ggaccggcca ggccctgccc
     5341 ggccccgggg tacccggcag ccaccgtctg aacagaccat tgcagttgag ggaagagtgt
     5401 cgtgcagttc cgccaacagg ccctttccaa gctgcagtcg cccgaggaaa tcgatctgcc
     5461 ggtgcggttc gcccggcccc agggctggct ggtgctgacg gtcacggtcc tcttcgtgtt
     5521 cgccgcctcc gtatgggcgg tgaccggcac cgtgtcgtcc accctgaacg cacccggaat
     5581 cctcacccac ggccagggca gctacgtcct gcagagcccg gtcgcgggcc aggtgaccgc
     5641 cgtacttgcc gaagaaggca aacgggtggc cgccaacacc cccattttga aggtccgtac
     5701 cccgcggggc agcaccgtcg tccgcgccct cgccgccggc cggctgacca ccatgtccgc
     5761 cacgatcggc gccgtcgtca cgaccggcgc cgaggtggcc tccgtggagc gcgtcgccca
     5821 tgaccgcgac cccctgacgg cgatgctgta cgtcccggcc cagagcggcg ccacggtgcc
     5881 cgtcggcgcc tccgtcgacc tcaccgtcca gtccgtgccg agccagcagt acggcgtgct
     5941 gcgcggccgg gtcaaggcgg tcggccggac cgcgcagacc cgccagcgga tcagcacctt
     6001 cctgggcagc agccagctcg gcgagcagtt ctcccggcac ggccagccgg tggcggtcct
     6061 cgtccagctc gaccccgccc cgcacaacag gtccggctac gcctggtcca cctccgacgg
     6121 cccgccgtac gccgtcgact ccatgaccct ggccgacggc gccgtccacc tggccgcgca
     6181 gcacccgatc gattggctgc tgccgtgacc gcgccgcacg actccgccgc cccgcagccg
     6241 cagttgccgc cgcccggccg cggacggcac cgccccgagg ccggccccgg cgcccgccgt
     6301 acccgccggg cggcaccgcc ggcccccaag cccaagaaga cccgggccgt ccgcaccccc
     6361 accgtcctcc agatggaggc cgtggagtgc ggcgccgcgt ccctggccat ggtgctggcc
     6421 cactacggac ggcatgtgcc cctggaggag ctgcggatcg cctgcggtgt ctcccgtgac
     6481 ggctcgcgcg ccagcaacct gctcaaggcc gcccgcagct acgggctgca ggccaagggc
     6541 atgcagatgg aaccggccgc gctcgccgaa gtccaggcgc cggccatcct gttctgggag
     6601 ttcaaccact acgtcgtcta cgacggcacg gcccgtcgct tcggccgccg cggtgtccac
     6661 atcaacgacc ccgacaaggg ccgccgcttc gtggcgacgg aggacttcga caccagcttc
     6721 accggcgtcg ccctggtctt cgagccgggc gaggacttcc gcaagggcgg ccgcaagccc
     6781 ggcatcctca gcgccgtccc cgcccggatg cgcggaacga ccggcaccct gctggccgcg
     6841 ctcctcgcca gcctgctgct ggtcgcggtc ggtgccgcgg tgcccgcgct gagccgtacg
     6901 tacatcgaca tgttcctgat cggcaaccag acctcgctgc tggggccgct cttcgcgtcg
     6961 atggccgcga tggtggcgct gaccgccgtg ctgaccggcc tgcaacaggc gaacctgctg
     7021 cgcggccgga tcatctcctc caccctcacc agcgcccgct tcctgcgcca tctgctcaga
     7081 ctcccggtca ccttcttcgc ccagcgcagc ccggccgacc tggtccagcg gctgcagtcg
     7141 aacgacgcgg tggccgagac cctggcgcgc gacctcgccg ccgccgcggt ggacggcgtc
     7201 gtcgtcatcc tctacgcctt cctgctgtgg acctacgacc cccaactgac cgtcatcggc
     7261 gtggggatcg cactgctcaa cgtcgtcgcc atgcggatcg tggtccggct gcgggccacc
     7321 cacacccaga aactgcgcgc cgacaccgcc cggctgacca acaccgccta caccggtctg
     7381 cagctcatcg agacgatgaa ggccaccggc ggcgagaacg gctacttccg ccgctgggcc
     7441 ggccagcacg ccaccacgtt ggaggaacag cagcgcctcg gggtgccgag cgcctggctg
     7501 gccgtggtcg ccccgaccct cgccacgctc aacagcgcgc tgatcctgtg gatcggcggc
     7561 ctccgggcgg tcgagggcca tatctccatc ggcctgctgg tcgccttcca ggcgctggtc
     7621 acccgcttca ccgcaccgat cacccggctc aacggagtgg ccggccgcat ccaggacttc
     7681 gccgccgacg tggcccggct caaggacgtc gagagcttcc ccgccgacac cctctactcc
     7741 cgccccggcc cggactccga cacccggcgg ctcaagggcc atgtgacgct cgaagacatc
     7801 accttcggct acagcccgct ggacaaacca ctgctcaccg gcttctcgct ggccgtcggc
     7861 cccggccggc aggtcgccct cgtcggcggc tccggcagcg gcaagtccac cgtctcccgg
     7921 ctgatctccg gcctctacag cccctgggaa ggcgccatcc gcatcgacgg gcagcgcctg
     7981 gaggatctct cccgcagcgc gctggccgcc tccgtgtcct tcgtcgacca ggacatcttc
     8041 ctcttcgagg gcacggtccg cgacaacgtg gcgctgtggg acccctcgat ccccgacgac
     8101 gcggtcatca ccgccctcaa ggacgccgcc ctctacgacg acgtcatcgc ccggcgcccc
     8161 gacggcatcc acagccgcgt cgagcaggac ggccgcaact tctccggcgg gcagcggcag
     8221 cggctggaga tcgcccgcgc cctggtccgg cgccccagca tcctggtcct cgacgaggtc
     8281 accagcgcac tggacgcccg gaccgagcag atcatcatgg acaacctgcg gcgccgcggc
     8341 tgcgcctgcg tcatcatcgc ccaccggctg agcaccgtcc gcgacagcga cgagatcgtg
     8401 gtcctcgacc acggcgtggt cgtcgaacgc ggccggcacg agcacctcgt cgccgccggg
     8461 ggcccgtacg ccgagctggt caaggagcac tgacgtgtca tccatgcccc cgcccgcggt
     8521 cgtgggaccg ggcgacaccg acgcggtgac ccaggcgctg ggcactctgg gcacgcccgt
     8581 cgactgcacc gggctgcgca gcgttcccct ggagggcccg catgtgctgt ggctcgtcac
     8641 gggcggcgcg ctggacctct tcgccgtcga cgccgcccag gaggggcact ggcacttcct
     8701 cggccggctc gaagcgggcg ccctgctgct cggcccggtc gagggcccgc agcacaccct
     8761 gctcggccgc ccgtcgcagg actgccggct gcgccggatc ccgctgcgcg aactggcccg
     8821 ccccgagtgg gagacggggc agtacgcgac ggtggggcag tacggcgagc agagcccgta
     8881 cggctacggg tacgccggcc acggtgagcc ggccccctcc gcgctggagc acgccttcgc
     8941 cctgggcacc gcccgcagcc tgggcgtgct gttcgaggcc ccgctcgacg gccggcccgg
     9001 cgacgaggcg gtggccgacg acgacgtcct gtggatgccg gtcccgcccg gcagcgtgca
     9061 gtacggcgcc tcctacagcg cggaggcggc cggcgatctg ctggtcgacc ccggactgtg
     9121 gcagcagatg gtcaatcagc aataccggct gctgtccgcc gtcgaccggt ggatcgagca
     9181 gctggagcgc gcccacgagg accgcacggc ggccggcatc aaggccggcg aggcggtccg
     9241 cgagcgggcc gaccaggcgc tgctggcctc catcggccgc ccggaccggt ccgggcgggg
     9301 cagcgacggg ccgggccggg ccggcgacga cgccaccttc gcggtctgcc gtacggtcgc
     9361 ggaggcggcc gggatcaccc tcaccgaacc gcccaagggc ggggccgtca acgaccgcat
     9421 caccccggtc gaacggatcg cggtcagctc gcggatccgg acccgcgcgg tccggctcca
     9481 gggccgctgg tggcggacca acaccggccc gctggtgggc cggcgcgcca agtccggcgc
     9541 cccggtggcc ctgctctggc ggcgcggtcg ctacgaagcg gtcaatccgg cctccgggat
     9601 gcggatgcgg atcggcaagg acaacgccga ggagctcgaa ccgcgcgccg tgatgttcta
     9661 ccgcccgctg ccggagcggc ccatgagcat gtggcgactg atgcgcttca gcctgcgcgg
     9721 cacccggatg gacgtccgca acctggccct cagcgggctg gtgacggtcg ccctcggcgc
     9781 gctcgtcccg ctcgcgaccg gcagggtgct cggggtgtac gtgcccagcg cccagaagag
     9841 cctgatcgtc caggtcgcgc tggccgtcat cgtcaccagc atcgtctccg ccgccttcat
     9901 gctgctgcag aacctcaccg tcctgcggat ggagggccgg atcgagagtg cgctgcagcc
     9961 ggccgtgtgg gaccggctgc tgcggctgcc ggcgaagttc ttcaccgaac gctccaccgg
    10021 cgagctggcc agcgccgcga tgggcatcag cagcatccgg cgggtgctgt ccggggtcgg
    10081 cccggtggcc gtgcagtccc tgaccatcgg cgcgatgaac ctcgtcatgc tgctgtgctt
    10141 cagcgtgccg ctggcactgg cggcgatcgg catgctgatc gtcatcggcg cggtgttcct
    10201 cgccatgggc ctgtgggagc tgcgctgg
//
