LOCUS       NZ_LT907981            10936 bp    DNA     circular CON 12-FEB-2024
DEFINITION  Streptomyces sp. 2323.1 chromosome I.
ACCESSION   NZ_LT907981
VERSION     NZ_LT907981.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 2323.1
  ORGANISM  Streptomyces sp. 2323.1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 03:31:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,058
            CDSs (total)                      :: 6,971
            Genes (coding)                    :: 6,808
            CDSs (with protein)               :: 6,808
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 163
            CDSs (without protein)            :: 163
            Pseudo Genes (ambiguous residues) :: 0 of 163
            Pseudo Genes (frameshifted)       :: 64 of 163
            Pseudo Genes (incomplete)         :: 123 of 163
            Pseudo Genes (internal stop)      :: 17 of 163
            Pseudo Genes (multiple problems)  :: 37 of 163
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5289291
            Orig. end                         :: 5300227
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT907981.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10936
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="25"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10936
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10936
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5936](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5936
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    731..743
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    762..776
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.39"
                     /tool="antismash"
     gene            857..1141
                     /locus_tag="CPH93_RS22715"
                     /old_locus_tag="SAMN06272775_4619"
     CDS             857..1141
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (15-81). E-value: 3.7e-13.
                     Score: 41.6. Matches aSDomain:
                     nrpspksdomains_CPH93_RS22715_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="CPH93_RS22715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_4619"
                     /product="acyl carrier protein"
                     /protein_id="WP_096213910.1"
                     /sec_met_domain="PP-binding (E-value: 6.7e-12, bitscore:
                     44.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAKLSDETIKQVTVEIVVDELELDVEPDEVDLTANLIDEYEADS
                     LGLIQILARVNKELAIRLPREEVGDLRTVDQMVRRIIELRAGEEAVNAG"
     aSDomain        902..1099
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPH93_RS22715_PP-binding.1"
                     /evalue="3.70E-13"
                     /label="CPH93_RS22715_PP-binding.1"
                     /locus_tag="CPH93_RS22715"
                     /protein_end="81"
                     /protein_start="15"
                     /score="41.6"
                     /tool="antismash"
                     /translation="EIVVDELELDVEPDEVDLTANLIDEYEADSLGLIQILARVNKELA
                     IRLPREEVGDLRTVDQMVRRI"
     gene            1131..2387
                     /locus_tag="CPH93_RS22720"
                     /old_locus_tag="SAMN06272775_4620"
     CDS             1131..2387
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (85-402). E-value:
                     3.2e-46. Score: 150.0. Matches aSDomain:
                     nrpspksdomains_CPH93_RS22720_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019548304.1"
                     /locus_tag="CPH93_RS22720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_4620"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_096213911.1"
                     /sec_met_domain="t2fas (E-value: 4.9e-106, bitscore: 353.6,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.3e-35, bitscore:
                     121.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLASTRRVVVTGIGCVSSIGTGVEDFTEGIKRGQSGISEIRSFDS
                     SDFTSHLGGEVHDFAPETIVHTIDPDDWGRTAQIAAAAARLALQDSDIDLSEDLRLTTG
                     AIIGTTNGEAPTVDTLTGQWLDRGPGLMDAALVSLLPAGNIAAAVSVELGLYGETMTIP
                     TACSAANYAIGSAGDKIASGEADVMFAGGSDSVNRFTHAGFLSLGAIADGVGRPFDRNR
                     TGIVTAEGGAVLMLEELEHAVRRGAHIYAELLGYGLSCDAHHIVHPDADSIANCIRRAH
                     AHSGIDTSSVDYISAHGTGTPTNDVTEVTATRSVFGDAHPPMSSIKSMLGHTMGAASGF
                     GAIACCKAIEESFLPPTINLEEVDPELGPGIDFVAGEARSAQVKVAQNHGFAFGGNNAI
                     TIFGAVADQPVPAVAGESV"
     aSDomain        1386..2336
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPH93_RS22720_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.20E-46"
                     /label="CPH93_RS22720_PKS_KS.1"
                     /locus_tag="CPH93_RS22720"
                     /protein_end="402"
                     /protein_start="85"
                     /score="150.0"
                     /tool="antismash"
                     /translation="LALQDSDIDLSEDLRLTTGAIIGTTNGEAPTVDTLTGQWLDRGPG
                     LMDAALVSLLPAGNIAAAVSVELGLYGETMTIPTACSAANYAIGSAGDKIASGEADVMF
                     AGGSDSVNRFTHAGFLSLGAIADGVGRPFDRNRTGIVTAEGGAVLMLEELEHAVRRGAH
                     IYAELLGYGLSCDAHHIVHPDADSIANCIRRAHAHSGIDTSSVDYISAHGTGTPTNDVT
                     EVTATRSVFGDAHPPMSSIKSMLGHTMGAASGFGAIACCKAIEESFLPPTINLEEVDPE
                     LGPGIDFVAGEARSAQVKVAQNHGFAFGGNNAITIF"
     misc_feature    1392..1394
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2459..3484
                     /locus_tag="CPH93_RS22725"
                     /old_locus_tag="SAMN06272775_4621"
     CDS             2459..3484
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012337.4"
                     /locus_tag="CPH93_RS22725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_4621"
                     /product="beta-ketoacyl synthase N-terminal-like
                     domain-containing protein"
                     /protein_id="WP_159395039.1"
                     /sec_met_domain="t2fas (E-value: 3.7e-15, bitscore: 54.3,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 6.2e-11, bitscore:
                     41.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRERLNAPAAEELPLNPPPQADAGDYAGIPGEISAVPSFDITDFV
                     PKKGTKNIDRTTALGLAASARLKQTLTEHAGITDDSWQSTGVAMGSMVGSLRSSVELDS
                     SVIEGAGIDLVNPARFPNTTMNCCASQVAIWHCFRGPNSTLANGNLSAVSALQYAARLI
                     HRGHGQRMCVGGVEELSPHTAWGIRSKKIVHDTVPVSEAAAVFALEPEGLSQAPALATV
                     PACAVGFAPERTNAGFADALRRVVVGVLRQAEVDATAVDLVLPGSEGTVLAEAEQAALA
                     GFTAERVDVRKALGECGSATGALQVAAALAVGRPGSTALITGIDISGAVGAAVLRIGAG
                     T"
     gene            3481..5004
                     /locus_tag="CPH93_RS22730"
                     /old_locus_tag="SAMN06272775_4622"
     CDS             3481..5004
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="CPH93_RS22730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_4622"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_096213913.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.5e-06, bitscore:
                     26.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPRILIVGAGPVGLAAAVSLRLQGVPVTVVDKAVTPHTHPKAVV
                     LWPRALEIFDRLGVADRLEAAGHPLTGQHYHSNGTRVASLTFRRLRHTKYRYALAIPQH
                     TTERVLREQLSELDGSIRAHTELTALRQGADTVTTTLADLDTGTTREETYDWVIGADGV
                     HSSVRSATGIGFEGQTYEQTFLLSDGPCDTRLATDSAHYFMTDTGVLVMVPLPDQQWRA
                     FISAPREIPEGEPLVDTVARVVSQRSPVPVRFLDGHAAGRFRIHRKTAERVWQGRVFLV
                     GDAAHAHSPAGAQGINTGVEDATSLAWRLGGICRGSVPTADSEQVFTQWSDERHQVVAN
                     VLRDTDLQTRLWGVRGFRRRLRDAVLYGAERTGLLDRVVIPRQTQIVQRYSPGPGQGRS
                     KAAGVLRSHARLPNLEIPGASGGTRLHDFLSPTEPIALEFDPAGTPGHHTKVRRAAAQG
                     SGLDVVSLSGPALRSALGISRRVTCVVRPDGIVAEIAPATAAGKGDGTP"
     misc_feature    3541..3543
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5001..5936
                     /locus_tag="CPH93_RS22735"
                     /old_locus_tag="SAMN06272775_4623"
     CDS             5001..5936
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015700.4"
                     /locus_tag="CPH93_RS22735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_4623"
                     /product="AfsA-related hotdog domain-containing protein"
                     /protein_id="WP_096213914.1"
                     /sec_met_domain="AfsA (E-value: 4.2e-14, bitscore: 51.0,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAVKRISQKLVHRANAREILVSPPNWGAEHRYHATTVTTDISP
                     YYLDHHGRHRLDLVLMTEACRQAAISAAHRYEGLPLGVAAFFNSIDVRLSNVDMLANSS
                     NELMITTSMEEMKLRGDGSPKQIVYSQEAVVIGSDKPVLSARMAVQGVAEGRYPDLRAY
                     QRNGSAAPTTASMRATFRRHQDMAEPERVGRTQTANVVLAGLRRTEDGATAILDADLAN
                     ASLFDHDYDHYPAMVLIEAGRQLALACTERAVDWIISGCHAEFPGFAELDTQTVVIARQ
                     DRNHVEVVCRQNDVDVTHMRFELTSVVGQS"
     gene            5933..6604
                     /locus_tag="CPH93_RS22740"
                     /old_locus_tag="SAMN06272775_4624"
     CDS             5933..6604
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012905.4"
                     /locus_tag="CPH93_RS22740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_4624"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_096213915.1"
                     /sec_met_domain="HAD_2 (E-value: 0.0052, bitscore: 15.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRLAIWSDFRGVLTPPLAEGVRRFCEGRNFTPAQIRRSLRSIAE
                     RHGCPDGMAVLDSGVLDERRWTGEIERDLLDCFGITADLSDFATRWWSDQRLDDAWVAA
                     LREWRAAGAFVGLLSNLPAEWRTPLASFPAVADTFDDVLLSCDVGTRKPESEIFRLAEA
                     RSGLAPRFHVLADDLPENVAGARQAGWAGVLSGGDATKSAIALIDSMVSGDAAMSEGVS
                     R"
     gene            6601..7311
                     /gene="fabG"
                     /locus_tag="CPH93_RS22745"
                     /old_locus_tag="SAMN06272775_4625"
     CDS             6601..7311
                     /EC_number="1.1.1.100"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (6-156). E-value: 2.8e-21. Score:
                     68.2. Matches aSDomain:
                     nrpspksdomains_CPH93_RS22745_PKS_KR.1"
                     /codon_start=1
                     /gene="fabG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567714.1"
                     /locus_tag="CPH93_RS22745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_4625"
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="WP_096213916.1"
                     /sec_met_domain="adh_short (E-value: 1.4e-37, bitscore:
                     128.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSRSAFVTGANRGIGEAIARDLAKRGYRVVGTYRSNRPEVDGVS
                     FVHCDVRDPESVASAVREARETLGEIDVIVSSAGVTQDGLLMSQAPDDVAGVLDTNLTG
                     AFNLVREAVTDMVANKWGRIVFVSSVMGAWGSPGQTSYAASKSGLTGLTRSLAWELGRA
                     RVTANAVLPGLIETEMIAGLSDRRRDQVVSQTPLRRTGTPEEVAALVGFLVSDEAAFIT
                     GASIPIGGGIGMGL"
     aSDomain        6619..7068
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPH93_RS22745_PKS_KR.1"
                     /evalue="2.80E-21"
                     /label="CPH93_RS22745_PKS_KR.1"
                     /locus_tag="CPH93_RS22745"
                     /protein_end="156"
                     /protein_start="6"
                     /score="68.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="FVTGANRGIGEAIARDLAKRGYRVVGTYRSNRPEVDGVSFVHCDV
                     RDPESVASAVREARETLGEIDVIVSSAGVTQDGLLMSQAPDDVAGVLDTNLTGAFNLVR
                     EAVTDMVANKWGRIVFVSSVMGAWGSPGQTSYAASKSGLTGLTRSL"
     CDS_motif       6622..6684
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPH93_RS22745_0001"
                     /evalue="3.10E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="CPH93_RS22745"
                     /protein_end="28"
                     /protein_start="7"
                     /score="16.6"
                     /tool="antismash"
                     /translation="VTGANRGIGEAIARDLAKRGY"
     CDS_motif       6973..7032
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CPH93_RS22745_0002"
                     /evalue="2.90E-07"
                     /label="PKSI-KR_m4"
                     /locus_tag="CPH93_RS22745"
                     /protein_end="144"
                     /protein_start="124"
                     /score="23.0"
                     /tool="antismash"
                     /translation="VFVSSVMGAWGSPGQTSYAA"
     gene            7377..8654
                     /locus_tag="CPH93_RS22750"
                     /old_locus_tag="SAMN06272775_4626"
     CDS             7377..8654
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CPH93_RS22750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN06272775_4626"
                     /product="hypothetical protein"
                     /protein_id="WP_096213917.1"
                     /transl_table=11
                     /translation="MNAARTTSFYPWREEYVTLPVPSGNGTDASIGLLKIGDPNAKTVV
                     LFLGGKEGAAAGFTALGRTVAAVAPGVQFWAMDRREVFLTDTSQADAPLDEALGYYLEG
                     RYQSPDPENFAEYAEWGLQVLVDDLRVAVAAAAEGGRKVLLGGHSVGAAEVVHYASWDF
                     GGVAGHRSIDGLVLVDGGALNAFRGAGMEFGIDLDTARGWLGGIRAGGVFETETSTSAT
                     LGFDGPPETAALIYKLAARALLEQPTAVSPLAAHLPARYPVPDSATNHEVFAALVNLGN
                     AKPGYGVTAGRFEGGNWVQEGPTRLGVVAHAHSLGAGAFQWRTLNRTLLDLIAVDSLRQ
                     NEITELLGLRGLHAAEIDVPVLAYASAFTNGSSLDAAKELAQLSAISRLDLVEDKALSH
                     HDVLFADLPANSLVRALASFAGSLAA"
     gene            8683..10215
                     /locus_tag="CPH93_RS22755"
                     /old_locus_tag="SAMN06272775_4627"
     CDS             8683..10215
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="CPH93_RS22755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_4627"
                     /product="MFS transporter"
                     /protein_id="WP_096213918.1"
                     /transl_table=11
                     /translation="MTSTESVHRTGADESPAHRRPTWLVLAVASVAVVIVPLGVSGTPL
                     LLPGIGTDLGGGLAPLQWVVNAYNVAAASTMLATGVLADQYGRRRVFRLGAGLYLVSLL
                     ATILAQDTLVIDVARAAAGIGAGAIVTSMTAIVANAFDGPARAKAFGLVGVVIGAGLAL
                     GPTISGAIAQLLDWRAVFGFHAVIVALGLLGSLLLPESRNRGGSRFDFLGAGLFTVALL
                     LLTIGTIEGPQSGWADVRTIALFAGAVLAFVLFVVHERRTSNPMFELSLFADRQFLTVN
                     LVNIEFAFGFIGLLLLLPAFLFSVGGLGNGAAGLRILLLTVPIFLVPMVSGRLSAAGVP
                     LRLILAGGLALIGVGAFGLTFAEGDSALWVLAVPLVVTGAGVGVLNGVMDGAAVGSVPN
                     TSAGMAAGMFNTIRLAAESLASVVVVALVASFVHTQLSAASLPAGLNAATAADELAAGD
                     VKQLFAQYPDQAHTLASAHASAFHQVMWISVVLAAVSVVTVLVLLRRQDSRR"
     gene            10212..10592
                     /locus_tag="CPH93_RS22760"
                     /old_locus_tag="SAMN06272775_4628"
     CDS             10212..10592
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019589.4"
                     /locus_tag="CPH93_RS22760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_4628"
                     /product="hypothetical protein"
                     /protein_id="WP_096213919.1"
                     /transl_table=11
                     /translation="MTAARQLPLTAVDGIEAKDGGFVGRKKVSAEDPYLSGHFPSLTVY
                     PGVFLIEGVQQMLELHLDGVLGGIELVSIESARFSRPVLAGDEVLFDTRVTGERPLLTT
                     ATTCTVDGRRCARIAATWRCAS"
ORIGIN
        1 tccgcggggg tacgtccccg gctgggaagc cgtcggcacg gtcctggagg ccggcccggc
       61 cacctcgcgg ttccagcccg gtgacctggt cggcacgctc ggacagatgg gcggctgggc
      121 cgagtaccgg gcggtggacg agcggctcgc cttccgtctg ccctcgggca gctcgccgac
      181 gtcgatggcg gtcatcggag tcgccggcgg caccgcgatc cgggcgatcc gccgattggg
      241 gtcgacgctg ggggtgcggg tcatggtcac cggcgcggcc tccgccgtgg gtgtcttcgc
      301 cgtccagctg ctggccatgg ccggtgcgtg tgtcgtcgcg gtggaccgca agagggaacg
      361 gcattcccgg cactgtgaat tgggtgccga agacgtaatc agtacgccgg ccgaaaatcg
      421 tgagccggtc ggagcggtta ttgataccgt cggaggcgaa gtcctcgttc aggcgtttcg
      481 gcaactgagc gccaacggcc gacttattgc ggtcggccat actgcacgcg agtgcgagaa
      541 gtttcagttg ggggacttcg agggggatga cggccggcac ggccgtgtca tcgaaacgat
      601 gtacctgctg caggatgacc cgcggcgcac actcgccgac gatgtcgagt ggctggcccg
      661 acgggtcgac gacggggaca ttctgactcc cgaaatcctc gtccaggaga aatctgcttt
      721 tgcgtcgacg gtgacgctga aacccaggcc gaatggatgg gtgaaaaccg tcttcaaggt
      781 cagttgaagc cgtatcgcac ccttgggcgg tacggccgat gatttcggct gcctaaaaac
      841 atcaatgggg gattaaatgg aagcgaagct cagcgacgaa acgatcaagc aggtcaccgt
      901 ggagatcgtc gtcgacgaac tggagctcga cgtcgagccc gacgaggtcg acctgaccgc
      961 gaacctgata gacgagtacg aggccgactc gctcggactg atccagattc ttgccagggt
     1021 gaacaaggaa ctggcgatcc gcctgccgcg tgaagaggtc ggcgacctgc gcaccgtgga
     1081 ccagatggtc cggcggatca tcgagctccg cgccggcgag gaggccgtca atgctggcta
     1141 gtacccgccg cgtggtcgtc accggaatcg gctgcgtcag cagcatcgga accggtgtcg
     1201 aggatttcac cgagggcatc aagcgcggcc agagcggcat ctcggagatc cgctcgttcg
     1261 acagcagcga cttcaccagc catctgggtg gcgaagtgca cgacttcgcg cctgagacga
     1321 tcgtccacac gatcgacccc gacgactggg gccggaccgc gcagatcgcg gccgcagcgg
     1381 cccggctggc attacaggac tccgacatcg acctgtccga agacctccgg ctgacgaccg
     1441 gggccatcat cgggacgacc aacggggagg cccccacggt cgacactctg accggccagt
     1501 ggctggaccg cggtcccggc ctcatggacg ccgccctggt cagcctgttg cccgcgggca
     1561 acatagctgc cgccgtatcg gtcgaactcg gcctctacgg cgagacgatg acgattccga
     1621 cggcctgttc agccgccaac tacgccatcg gcagcgccgg tgacaagatc gcttcgggcg
     1681 aggcggacgt catgttcgcc ggcggatccg acagcgtgaa ccgcttcacc cacgccggat
     1741 tcctcagcct cggcgccatc gccgacgggg tgggacggcc cttcgaccgg aaccggacgg
     1801 gcatcgtcac ggccgagggc ggtgcggtgc tcatgctgga ggaactggag cacgccgtcc
     1861 gccgcggcgc ccacatctac gccgaactgc tcggctacgg gctttcctgc gacgcgcacc
     1921 acatcgtgca cccggacgcg gacagcatcg cgaactgcat ccggcgggcc cacgcccatt
     1981 cggggatcga caccagcagc gtcgactaca tctccgccca cggcacgggc acgccgacca
     2041 acgacgtcac cgaagtcacc gccacccgca gcgtgttcgg tgacgcgcac ccgccgatga
     2101 gctccatcaa atcgatgctg ggtcacacca tgggagcggc cagcggattc ggcgcgatcg
     2161 cctgctgcaa ggccatcgaa gagtccttcc tgccgcccac gatcaacctc gaagaggtcg
     2221 atccggagct cgggcccggc atcgacttcg tcgccgggga agcgcgcagc gcacaggtga
     2281 aggtcgccca gaaccacggc ttcgcgttcg gcgggaacaa cgcgatcacg atcttcggcg
     2341 ccgtcgcgga tcagcccgtg cccgccgtag caggggagtc ggtgtgatgt cccaggccag
     2401 tgcacctcgg atcactgata tttctgtcct gtccgtcgct ggcgtcggca tggaggcctt
     2461 gcgggagcgc ctgaacgcgc ccgccgccga agagcttccg ctgaacccgc cgccgcaggc
     2521 cgatgccggg gactatgccg gcattcccgg cgagatctcc gccgtaccct ccttcgacat
     2581 caccgatttc gtgcccaaga agggcacgaa gaacatcgac cgcaccaccg cgctcgggct
     2641 agcggccagc gcccggctca agcagacgct gaccgagcac gccggcatca ccgacgactc
     2701 ctggcagtcc accggtgtcg cgatgggcag catggtcggc agcctccgca gcagcgtcga
     2761 actggactcc agcgtgatcg agggggccgg tatcgacctg gtcaacccgg cccggttccc
     2821 caacaccacg atgaactgct gcgccagcca ggtcgcgatc tggcactgct tccgcggccc
     2881 gaactcgacg ctcgccaacg gcaacctcag cgccgtctcg gccctgcagt acgcggcccg
     2941 gctgatccac cgcggccatg gccaacggat gtgcgtgggc ggggtggagg agctgtcccc
     3001 gcacacggcc tggggcatcc ggtcgaagaa gatcgtgcac gacaccgtgc ccgtcagcga
     3061 ggccgccgcc gtgttcgcgc tcgaacccga ggggctcagc caggcgcccg cgctagcgac
     3121 ggtaccggcc tgcgcggtgg gcttcgctcc cgagcgtacg aacgccggct tcgcggacgc
     3181 cctgcgccgg gtcgtcgtcg gagtgctccg gcaggccgag gtggacgcca ccgccgtcga
     3241 tctcgtactg cccggttcgg aggggaccgt gctggcagag gccgagcagg ccgcgctggc
     3301 cgggttcacc gccgagcgag tggacgtgcg caaggcgctc ggcgagtgcg gcagcgccac
     3361 gggagccctg caggtcgcgg cggcactggc ggtcggacgg cccggcagca ccgcgctgat
     3421 cacggggatc gacatctcag gtgccgtcgg tgcggccgtc ctgcggatcg gggcggggac
     3481 atgagccctc gcatcctgat cgtgggcgcc ggcccggttg gcctggccgc ggccgtctcc
     3541 ttacggctcc agggagtgcc ggtcacggtg gtcgacaagg ccgtcacccc gcacacccac
     3601 ccgaaggccg tcgtcctgtg gccgcgcgcg ctggagatct tcgaccgtct cggtgtcgcc
     3661 gaccggctgg aggccgcggg ccaccccctc accggccagc actaccactc caacgggacc
     3721 cgcgtcgcca gcctgacctt ccgcaggctc cggcacacca agtaccggta cgcgctggcc
     3781 atcccgcagc acaccacgga gcgcgtcctg cgggagcagc tctccgagct cgacggttcg
     3841 atccgcgccc acacggaact gaccgcgctg cggcagggcg cggacacggt gacgacgacg
     3901 ctggccgacc tggacaccgg taccacgagg gaagagacgt acgactgggt catcggggcg
     3961 gacggcgtcc acagctccgt ccgctccgcc accggtatcg gcttcgaggg ccagacgtac
     4021 gagcagacct tcctgctgtc ggacggcccc tgcgacacca ggctcgccac cgactccgcg
     4081 cactacttca tgaccgacac cggtgtgctc gtcatggtgc cgctcccgga ccagcagtgg
     4141 cgcgccttca tcagcgcacc ccgcgagatc ccggagggcg aaccgctcgt cgacacggtg
     4201 gcgcgcgtgg tgagccagcg gtcgccggtt ccggtgcggt ttctcgacgg tcacgcggca
     4261 ggccggttcc gtatccaccg caagaccgcg gaacgcgtat ggcagggcag ggtcttcctc
     4321 gtcggggacg ccgcgcacgc ccacagcccg gcgggcgcgc agggcatcaa caccggcgtg
     4381 gaggacgcga ccagtctggc gtggcgcctc ggcgggatct gccgggggtc ggtgcccacc
     4441 gcggactccg agcaggtctt cacgcagtgg tcggacgagc gccaccaggt cgtcgcgaac
     4501 gtcttgcgtg acacggatct ccagacccgg ctgtggggcg tacgcggatt ccgccggcgc
     4561 ctgcgggacg cggtgctgta cggggccgag cgcaccgggc tgctcgatcg cgttgtcatt
     4621 ccccgccaga cccagatcgt ccagcggtac agcccgggcc cggggcaggg gcgttcgaag
     4681 gctgccgggg ttctgcgcag ccatgcccgg ctgccgaacc tcgagattcc cggtgcatcc
     4741 ggtgggacgc gcctacacga cttcctgtcg ccgaccgagc cgatcgccct cgagttcgac
     4801 cccgcgggca ctccggggca ccacacgaag gtccggcgtg cggctgccca gggatcgggg
     4861 ctcgacgtcg tatcgctctc cggtccggcc cttcggtccg cactgggcat cagccggcgc
     4921 gtcacctgcg tggtgcgtcc ggacgggatc gtggccgaga tagctccggc caccgctgcc
     4981 ggcaaggggg acggcacacc atgaccacag cagtgaagcg catatcgcag aagttggttc
     5041 accgcgccaa cgcgagggag atcctggtct ccccgccgaa ctggggcgcc gaacaccggt
     5101 accacgccac gacggtcacc accgacatca gcccctacta cctggaccac cacggccggc
     5161 accggctcga cctcgtgctg atgaccgagg cctgccggca ggccgcgatc agtgcggctc
     5221 accggtacga aggtctgccg ctcggtgtcg cggcgttctt caactccatc gacgtccggc
     5281 tgagcaacgt cgacatgctg gcgaactcca gcaacgagct gatgatcacc acctccatgg
     5341 aggagatgaa gctgcgcggc gacggatcgc cgaagcagat cgtctactcg caggaggccg
     5401 tcgtcatcgg ctcggacaag ccggtgctga gcgcgcggat ggcggtccag ggagtggccg
     5461 aggggcggta tccggaccta cgcgcctacc agcgcaacgg ttccgcggca ccgaccaccg
     5521 cgtcgatgcg cgccaccttc cggcgccacc aggacatggc cgagcccgag cgggtcggcc
     5581 ggacgcagac ggccaacgtc gttctcgccg gactgcggcg gaccgaggac ggcgccaccg
     5641 cgatcctcga cgcggatctg gccaacgcaa gcctgttcga ccacgactac gaccactacc
     5701 cggcgatggt gctcatcgag gccggccgac agctcgccct ggcctgcacg gagcgcgcgg
     5761 tggactggat catcagcggc tgccatgccg agttcccggg atttgccgag ctcgacaccc
     5821 agaccgtcgt catcgcccgt caggaccgca accatgtcga ggtcgtctgc cggcagaacg
     5881 acgtcgacgt cacccacatg cggttcgagc tgacgtcggt ggtgggccag tcgtgacgag
     5941 actcgcgatc tggagcgact tccgcggcgt cctcaccccg cccctggcag aaggggtgcg
     6001 gcggttctgc gagggcagga acttcacgcc cgcgcagatc cgccggtcgc tgcggtcgat
     6061 cgccgagcgc cacggctgcc cggacggcat ggcggtgctc gactcgggcg tcctcgacga
     6121 gcgccgctgg accggggaga tcgagcggga tctgctcgac tgcttcggca tcaccgccga
     6181 cctgtccgac ttcgccactc gctggtggag cgaccagcgg ctcgacgacg cctgggtggc
     6241 agccctgagg gagtggcggg cggcgggcgc cttcgtcgga ctcctgtcca acctgccggc
     6301 cgagtggagg acgcccctgg cctccttccc cgccgtcgcg gacaccttcg acgacgtgct
     6361 gctgtcgtgc gacgtcggaa cccgcaaacc cgaatccgag atattccgtc tcgccgaggc
     6421 ccgctcgggc ctggcccccc ggttccacgt cctggccgac gacctgcccg agaacgtcgc
     6481 aggcgcccgc caggccggtt gggccggcgt gctctccggc ggagacgcga cgaaatccgc
     6541 gatcgcactc atcgactcga tggtgagcgg cgacgcggcg atgagtgaag gagtatcgcg
     6601 atgagctcgc gatcggcatt tgtcaccggg gccaaccgcg gtatcggtga ggccatcgct
     6661 agggacctgg ccaagcgcgg ataccgcgtc gtgggcacgt accgcagcaa ccgccccgag
     6721 gtggacggcg tctcgttcgt ccactgcgac gtccgcgacc ccgagtcggt ggcctcggcc
     6781 gtgcgcgagg cgcgggagac gctcggcgag attgacgtca tcgtcagcag cgcgggcgtc
     6841 acccaggacg ggctgctgat gtcccaggcc cccgacgacg tggccggcgt gctggacacc
     6901 aacctcacgg gcgccttcaa cctggtgcgc gaggccgtca ccgacatggt ggcgaacaag
     6961 tggggccgga tcgtgttcgt ctcctcggtg atgggcgcgt ggggctcgcc ggggcagacc
     7021 agctacgccg cgtccaagag cgggctgacc ggcctgaccc gctcgctcgc ctgggaactg
     7081 ggccgggcgc gcgtcaccgc taacgccgtc ctgcccggcc tcatcgagac cgagatgatc
     7141 gccggcctct cggaccgcag gcgcgaccag gtcgtctccc agacgccgct gcgccggacc
     7201 ggtacgcccg aggaggtggc agctctcgtc ggcttcctgg tctccgacga ggccgcgttc
     7261 atcaccgggg cctcgatacc aatcggcggc ggcatcggga tgggcctgtg acccgcctgc
     7321 ccgcctcgcc cccggtaacc acagaagtcc gaactcagcg aaaggcacga cacaccatga
     7381 acgcagcccg gacgacctcg ttctatccct ggcgtgagga gtacgtgacg ctgccagtcc
     7441 cgagtgggaa cggcacggac gcgtcgatcg gtctgctgaa gatcggcgac ccgaacgcca
     7501 agaccgtcgt gctgttcctc ggcggcaagg agggcgcggc cgccggcttc accgccctcg
     7561 gccggaccgt cgccgcggtc gcgcccggcg tgcagttctg ggcgatggac cggcgcgagg
     7621 tgttcctcac cgacacctcc caggccgacg cgccgctcga cgaggccctc ggctactacc
     7681 tcgaaggccg ctaccagagc cccgacccgg agaacttcgc cgagtacgcc gagtggggcc
     7741 tccaggtcct ggtcgacgac ctccgggtgg cggttgcggc ggccgccgag ggcgggcgca
     7801 aggtcctgct cggcgggcac tccgtgggcg ccgccgaggt cgtgcactac gcgtcctggg
     7861 acttcggcgg agtcgccggc caccggagca tcgacggtct ggtcctggtc gacggcggtg
     7921 cgctgaacgc cttccgcggt gcgggcatgg agttcggcat cgacctcgac acggcacgcg
     7981 gctggctggg cggcatccgc gcgggcggtg tctttgagac ggagacctcg acctcggcca
     8041 ccctcggctt cgacgggccc ccggagaccg ccgcgctgat ctacaagctc gcggccaggg
     8101 cgctcctgga gcagccgacc gccgtctcgc cgctggccgc ccacctgccc gcgcggtacc
     8161 ccgtgccgga ctcggccacc aaccacgagg tcttcgccgc cctggtcaac ctgggcaatg
     8221 ccaagccggg ctacggcgtg acggccggcc gcttcgaggg cgggaactgg gtgcaggagg
     8281 ggccgacccg gctcggtgtc gtcgcgcacg cccactcgct cggcgccggt gcgttccagt
     8341 ggcgcaccct gaaccgcacc ctgctcgacc tcatcgccgt cgactcgctg cggcagaacg
     8401 agatcactga gctgctcggc ctgcgcggtc tgcacgccgc ggagatcgac gtgccggtac
     8461 tggcctacgc ctccgcgttc accaacggct cctccctcga cgccgccaag gaactcgccc
     8521 agctgtcggc catcagccgc ctcgacctcg tcgaggacaa ggcgctgagc caccacgacg
     8581 tcctcttcgc cgacttgccc gccaactcgc tcgtccgcgc cctcgcctcg ttcgcgggct
     8641 cgctcgccgc gtaagccaaa actcacagac aggggtccca cagtgaccag cacggagtcc
     8701 gtccaccgca cgggcgccga cgaaagcccc gcgcaccgca gaccgacatg gctggtgctc
     8761 gcggtggcct cggtggcggt cgtcatcgtc cccctcggcg tcagcggcac gccgctgctg
     8821 ctgcccggaa tcggcaccga tctcggcggt ggcctcgccc cgctccaatg ggtggtcaac
     8881 gcgtacaacg tggcggcggc gagcacgatg ctcgccaccg gcgtactcgc cgaccagtac
     8941 ggcaggcgcc gggtcttccg cctcggtgcc gggctgtacc tggtctccct gctggccacc
     9001 atcctggccc aggacaccct ggtgatcgac gtggccaggg ccgccgccgg catcggtgcc
     9061 ggtgccatcg tgacgtcgat gacggccatc gtggccaacg cgttcgacgg cccggcccgg
     9121 gccaaggcct tcggtctcgt cggtgtggtg atcggcgccg ggctcgcact cgggcccacc
     9181 atcagcggcg cgattgccca actcctggac tggcgtgcgg tgttcggctt ccacgcggtg
     9241 atcgtggcgt tggggctgct cggctccctc ctgctgcccg agtcccgcaa ccggggtggc
     9301 agccggttcg acttcctggg ggcgggcctg ttcaccgtcg cgctgctgct gctgacgatc
     9361 ggcacgatcg agggcccgca gtccgggtgg gcggacgtgc gcacgatcgc cctgttcgcg
     9421 ggcgcggtgt tggccttcgt cctgttcgtc gtccacgagc ggcgtacgag caatccgatg
     9481 ttcgaactga gcctcttcgc cgaccggcag ttcctgacgg tgaacctcgt caacatcgag
     9541 ttcgcgttcg gcttcatcgg tctgctcctg ctgctccccg ccttcctgtt cagcgtgggc
     9601 ggactgggca acggggcggc tggcctgcgg atcctgctgc tgaccgtgcc gatcttcctg
     9661 gtgccgatgg tgtccggcag gctgagtgcc gcgggtgtgc cgctgcggct gatcctggct
     9721 ggcggcctcg ccctgatcgg cgtcggcgcg ttcggtctga ccttcgccga gggtgacagc
     9781 gccctgtggg tgctggccgt accgctggtc gtcaccggag ccggtgtcgg tgtcctcaac
     9841 ggagtgatgg acggcgccgc tgtcggctcc gtgccgaaca cctcggcggg gatggcggcg
     9901 gggatgttca acaccatccg cctcgccgcg gaatccctcg cctcggtggt cgtcgtcgcc
     9961 ctggtcgcgt ccttcgtcca tacgcagctc tcggcggcgt ccctgcccgc gggcctgaac
    10021 gccgccaccg cggccgacga actcgccgcg ggtgacgtca agcagctctt cgcgcagtac
    10081 ccggaccagg cccacaccct ggcgtcagcc cacgcctcgg cgttccacca ggtcatgtgg
    10141 atctcggtgg tgctcgccgc ggtgtcggtg gtgaccgtgc tggtgctgct ccgccgacag
    10201 gacagccgac gatgaccgcc gccaggcagc tgcccctcac cgcggtggac gggatcgagg
    10261 cgaaggacgg cggattcgtc gggcgcaaga aggtgagcgc cgaagacccc tacctgtccg
    10321 gccacttccc ctcgctgacc gtctaccccg gggtgttcct gatcgagggc gtgcagcaga
    10381 tgctcgaact ccatctggac ggcgtactcg gagggatcga actggtctcc atcgagtcgg
    10441 cccggttcag ccggcccgta ctggccgggg acgaggtgct gttcgacacg cgtgtcaccg
    10501 gcgagcgccc cctgctgacg accgcgacga cctgcaccgt cgacggccgg cggtgcgccc
    10561 ggatcgccgc gacctggagg tgcgcgtcat gaccgagtat ccggacccgg ccgatctgct
    10621 gccgtacggt catccggcgc tgcacatcga ccggatcctg gcccatcggc ccggcacgct
    10681 gaccgcggtg aaggccgtgt cccagcacga actcggcagc cacctcggat cggcgcggcc
    10741 cgcccgtctc ccctcgaccc tggtgctcga gtccttcctc caggcgtgcg ggctgctggg
    10801 cgcgctcgac gccggggacg aggggagcgg acggctgctc gtattcgggt cggcgcgcaa
    10861 cctgcgcttc gaagggtcgg tgcgggcggg cgaactcctc gtgcactcgg tggaactgct
    10921 cgacacccac gaggac
//
