LOCUS       NZ_LT907981            22244 bp    DNA     circular CON 12-FEB-2024
DEFINITION  Streptomyces sp. 2323.1 chromosome I.
ACCESSION   NZ_LT907981
VERSION     NZ_LT907981.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 2323.1
  ORGANISM  Streptomyces sp. 2323.1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 03:31:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,058
            CDSs (total)                      :: 6,971
            Genes (coding)                    :: 6,808
            CDSs (with protein)               :: 6,808
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 163
            CDSs (without protein)            :: 163
            Pseudo Genes (ambiguous residues) :: 0 of 163
            Pseudo Genes (frameshifted)       :: 64 of 163
            Pseudo Genes (incomplete)         :: 123 of 163
            Pseudo Genes (internal stop)      :: 17 of 163
            Pseudo Genes (multiple problems)  :: 37 of 163
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3743166
            Orig. end                         :: 3765410
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT907981.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22244
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="22"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22244
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22244
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12244](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12244)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(172..1281)
                     /locus_tag="CPH93_RS15745"
                     /old_locus_tag="SAMN06272775_3216"
     CDS             complement(172..1281)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089913.1"
                     /locus_tag="CPH93_RS15745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3216"
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_096213216.1"
                     /transl_table=11
                     /translation="MSRTAQRRRGLIALLAAVTATAATGGVILLTNNGKDAAADGGRAR
                     GPAHTTEITRTDLVVSKTVDGDLDYAQRRAVKSPVEGTVTKAARPGRTVSLGQPLYERD
                     ARPVVLLYGATPMFRAMKAGDRGPDVLQLERNLRDLGFGSRLYVDARYDTATEAAVKAW
                     QKSLGRTDANGKVGKGDIVFQRGPVRVVAADAALADAVGPSDKVLTVASTKPVVRASLD
                     AADRALAANGTKVEIAMPSGGTRRGKVTGVATPESTDSAEGAAPSGSGAPSGEDVEVEI
                     TLDGSAKPQQKDQQGTLSVKFVSESRKDVLTVPVEAVVALREGGYGLEVVQGATSHMVQ
                     VETGLSADGRIEVSGAGLAEGMKVGAAEQ"
     gene            complement(1278..1907)
                     /locus_tag="CPH93_RS15750"
                     /old_locus_tag="SAMN06272775_3217"
     CDS             complement(1278..1907)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089912.1"
                     /locus_tag="CPH93_RS15750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3217"
                     /product="hypothetical protein"
                     /protein_id="WP_096213217.1"
                     /transl_table=11
                     /translation="MTPQTFPRSRTARLALLVAVPTLALTTACGGTQSSDAGVASVSHA
                     PSTDRNKDGSGSASSAAQGKSAFYDAQMKYVQCMRKNVDKDFPDPKLSGYLDWTKIDEL
                     QEKPGNEEIAKGGKGGVCTDDMRKAMQEEPRRDVQKEYESMLAHAKCMRAHGLSKFANP
                     QLQDGNVIPGGDANPVSPEVSEDSPAYKQARQACKGKLLDGLDGMQ"
     gene            2040..2726
                     /locus_tag="CPH93_RS15755"
                     /old_locus_tag="SAMN06272775_3218"
     CDS             2040..2726
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958679.1"
                     /locus_tag="CPH93_RS15755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3218"
                     /product="response regulator transcription factor"
                     /protein_id="WP_093484337.1"
                     /transl_table=11
                     /translation="MPHVLLVEDDTSVRDGMELVLRRHGHAVDAVATGEEGLTLLSRPR
                     GGGIEIAVVDLMLPGIDGFEVCRRIRARSQLPIIMLTSRGDDLDVVSGLEAGADDYVIK
                     PITGRVLEARIRAALRRAGPATRTDSDDFAGLVIDRAGLTVTKHDAPVPLPPTELRLLL
                     ELSAAPGRVFSREQLLELVWEHDFLGDSRLVDAAVGRLRAKLEDVPARPRYIQTVRGFG
                     YRFGPL"
     gene            2734..4251
                     /locus_tag="CPH93_RS15760"
                     /old_locus_tag="SAMN06272775_3219"
     CDS             2734..4251
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089910.1"
                     /locus_tag="CPH93_RS15760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3219"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_096213218.1"
                     /transl_table=11
                     /translation="MTTTARTAPKLAATTGARRAAAARVRLPHIGGLRGRLIVTVVVVA
                     LISAVTATGLAYRESREAVLKRAQSAAVDDFRNRIERLAPELDVPTDRRAMARFAQDVS
                     SGLRGSLVVARYRELTAVTDPSADRTRITPELRAAVRTHSRVSVQRVEQGGRPWLVLGA
                     PVGLDAPTPHGSSAGPSGVEIYAVVSLAEEERDTAELVRSVQGGLVPVVLLAAVLALFA
                     ARTALRPVRRLARATRRLATGELSIRVEEKGRDELAELAHTFNETAGALEHSVGELREQ
                     EARARRFVADVSHELRTPLAAMTMVSSVLEEDADELTPDTAHAARTVSAETAKLARLVD
                     DLIEISRFDARAVALTVHELDLAEAVRATLAARGWSDRVEADLPPGIRARLDRRRLDVI
                     VANLVGNALRHGAPPVTLTVRAADDWLTLAVADHGPGLAPETARHVFDRFYKADSARTR
                     SEGSGLGMAIALENARLHGGTIEIAPPAPGVGAVFTLRLPLRTDSAS"
     gene            4248..4739
                     /locus_tag="CPH93_RS15765"
                     /old_locus_tag="SAMN06272775_3220"
     CDS             4248..4739
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CPH93_RS15765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN06272775_3220"
                     /product="GerMN domain-containing protein"
                     /protein_id="WP_096213219.1"
                     /transl_table=11
                     /translation="MMRPRPAAVCCLLAVAATGCGIRPTGVTDGGKAPSGISQGMRVYF
                     ASDSGPRGVSRPGAKIDDLNDAFKLLLAGPTSEERAAGLANLISRDGAYSATSRHGKVT
                     VNAPDRYFGPQDQSTGQLVCTIARAEVLLHDTRPDKVQVTIIGADGRAGPYQCQQFLSR
                     "
     gene            complement(4930..5826)
                     /locus_tag="CPH93_RS15770"
                     /old_locus_tag="SAMN06272775_3221"
     CDS             complement(4930..5826)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604215.1"
                     /locus_tag="CPH93_RS15770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3221"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_096213220.1"
                     /transl_table=11
                     /translation="MPAFSDTTPAWTVGDLTVRRIDEVAFPAQTGRWLLPDATPEVVAQ
                     APWLRPDFADDAGALRLAGHSFAVEVQGLRIVIDTGIGNGKPRANPAWHDLDTDYLQRL
                     TAAGFAPEEVDLVVLTHLHTDHVGWNTRADKGSWVPTFPRARYLTSRAEWDHWAGAEMD
                     EARRQMFRDSVHPVRDAGLLDLVEVPAEGTDIALGVRLLPTPGHTPGQVAVELRSAGQT
                     ALITGDCIHHPVQLLRPGIGSCVDVDPVQAEHTRRALLTSLAGTDTLLLGSHFPPPTAG
                     RVIPEGDGYRLLSVAPE"
     misc_feature    5894..5909
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.18"
                     /tool="antismash"
     gene            6172..6378
                     /locus_tag="CPH93_RS15775"
                     /old_locus_tag="SAMN06272775_3222"
     CDS             6172..6378
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604216.1"
                     /locus_tag="CPH93_RS15775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3222"
                     /product="hypothetical protein"
                     /protein_id="WP_093488934.1"
                     /transl_table=11
                     /translation="MTTAELTPQESARWALRAGLPLADDRLAPVTDTANHIQSVLGVLR
                     ELDFRQTPPAPVYQAGGPVGAAV"
     gene            6365..7804
                     /locus_tag="CPH93_RS15780"
                     /old_locus_tag="SAMN06272775_3223"
     CDS             6365..7804
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604217.1"
                     /locus_tag="CPH93_RS15780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3223"
                     /product="amidase"
                     /protein_id="WP_096213221.1"
                     /transl_table=11
                     /translation="MQPYELTLAGAATAIRAGELSPVELTESVLGRIGAVEDRLGAYVT
                     LAADSARRSAVRAEREIAAGRHRGPLHGIPFGLKDLIDAAGLPTTASSRVGAPHPPATD
                     SAVAARLSAAGAVLLGKTHTHEFGYGLTTPQTRNARDHDRIAGGSSGGSAVAVAAGAAT
                     FALGTDTGGSIRVPAALNGVVGLKPTYGLLPLQGVTSLSWSLDHVGPLTRTVEDAALVL
                     TALVGNQGPPGAPGAADTPALTGRSVTPAAPRADLPPPESADLTGLRIGIPRQHYFERV
                     DPGVEASVRAAIDQLHACGAELMDIDIPLARYLQATQWGLMVPEATAAHEQTLRSVPEL
                     YGEDVRVLLEAGALVPAGDYLRAQRSRALMREAWTELFQQVDVVAAPSVPMAAVKAGQQ
                     KVQWPDGTVEAVSDAYVRLCAPANITGIPALSLPVGPDGTGLPAGLQLMGRPFDEATVL
                     RVGRAYETASGSVGGPVPVAA"
     gene            7921..8493
                     /locus_tag="CPH93_RS15785"
                     /old_locus_tag="SAMN06272775_3224"
     CDS             7921..8493
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604218.1"
                     /locus_tag="CPH93_RS15785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3224"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_093484332.1"
                     /transl_table=11
                     /translation="MSPRPMTRPGGRSARVQESVHAAVRALEAEQGRDALTVPLVAARA
                     GVTPSTIYRRWGDLQELLSDVAVERLRPETEPADHGALRTDLEAWAEQFLEEMSSPPGR
                     AYIRDALAGDPDGSHAGQCSAYAAEQVDIILARAADRGEQAPDAEVVMDHIVAPMMYRL
                     VFRPGPLDASYAHGLVEATLSSLMPPG"
     gene            complement(8515..9144)
                     /locus_tag="CPH93_RS15790"
     CDS             complement(8515..9144)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604219.1"
                     /locus_tag="CPH93_RS15790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chitin-binding protein"
                     /protein_id="WP_096213222.1"
                     /transl_table=11
                     /translation="MTAFLGALALTGAFVAFSPHGAQAVTGVITYHTRPENRPHEILDP
                     GDDHCYGVGDGYGTVDNDTPTDLVLYNGRDCTGSVVTVVPHRDWRNARFGSLRLSSDGP
                     READPADAPDPSDSPEPSGDPDPSHSADPSDNGDPSDNGDPSDSAEPSDNQESPQNPDD
                     PDGTHAADGAQGQAQVHGHKQVHGHKPVHGHGQRQVHGQRQGRSAG"
     gene            9382..9942
                     /locus_tag="CPH93_RS15795"
                     /old_locus_tag="SAMN06272775_3225"
     CDS             9382..9942
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604220.1"
                     /locus_tag="CPH93_RS15795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3225"
                     /product="HAD domain-containing protein"
                     /protein_id="WP_093484330.1"
                     /transl_table=11
                     /translation="MTGSAARPLLFLDVDGPLLPFGGAAEDRAGGHPAYPAAGHLPPGA
                     GANPLLGRINPAHGPRLAALPCELVWATTWMHEANEYLAPLLGLPELPVLSWPESSAEE
                     DRDVRAGLHWKTRALVDRAAGRAFAWVDDEINDRDRAWVAAHHGPRALLLRVDPRCGLT
                     DADFRLLHDWLRRVGGEGGAGEA"
     gene            complement(10001..12244)
                     /locus_tag="CPH93_RS15800"
                     /old_locus_tag="SAMN06272775_3226"
     CDS             complement(10001..12244)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604221.1"
                     /locus_tag="CPH93_RS15800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3226"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_096213223.1"
                     /sec_met_domain="T1TS (E-value: 9.2e-82, bitscore: 274.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQQPFELPTFYTPYPARLNPHLEAARTHSRTWARSMGMLEGSGI
                     WEEPDLDAHDYALLCSYTHPDCDADALSLVTDWYVWVFFFDDHFLEKFKRTLDREGGKA
                     YLDRLPAFMPMDLTAPVPEPVNPVEAGLADLWARTVPHMSMDWRRRFAESTEHLLNESL
                     WELSNIDIHRVPNPVEYIEMRRKVGGAPWSAGLVEYATGAEVPAAVAGSRPLRVLRDTF
                     SDGVHLRNDLFSYQRETEEEGELSNGVLVLETFLQCTTQEAADSVNDLITSRLQQFENT
                     VVGELPALFAEKGLDPKSCADVLAYAKGLQDWQSGGHEWHMRSSRYMNGGGSAARTSPA
                     WSPYPLGGLGTSAADLRRALATAGAHRLRSTTHVPHRKVGPSRIPDIHMPFTTTLSPHL
                     EGARRRVVEWAHRMGILRPQPGVPLSDVWDEPAMIRHDLALCAAGIHPDATADQLDLSA
                     AWLAWGTYADDYYPQVFGRPRDLPAAKVCTERLSSFMPLDLSAPAPEPVNALERGLADL
                     WSRTAGPMTPEARRAFRQSVDTMTASWLWEIDNQIQNRIPDPVDYVEMRRATFGSDLTM
                     SLSRIGHGRQVPPEVYRTGALRSLENSAADFACLMNDVFSYQKEIEYEGEVHNGILVVQ
                     TFFDCDYPTALHIINDLMTSRMNEFRHVAAHQLPVVYDDFDLSPEARKALDGYVQELEN
                     WMAGILIWHRGCRRYIEPELRYPTGAPGWLGAPSGLGTSAARLFRSAVGVGVG"
     gene            complement(12403..13251)
                     /locus_tag="CPH93_RS15805"
                     /old_locus_tag="SAMN06272775_3227"
     CDS             complement(12403..13251)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604222.1"
                     /locus_tag="CPH93_RS15805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3227"
                     /product="alpha-L-glutamate ligase"
                     /protein_id="WP_096213224.1"
                     /sec_met_domain="RimK (E-value: 2.4e-06, bitscore: 25.9,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRICLLTADPGHPLLAAVTALLAPEHEVVSLDPGSATAGPALFPL
                     ADVYLLKARTPRALALAAFLEEHGAPVLNSAAATARCQDRVAMADVARAAGLPFAATTA
                     LTTVGRLAAAGDPATPLVLKSRFSRRHDLVARADSAARLRELAADWAAEPVVVQEFTAN
                     SGWDHKLWVVDGRLFAGLRRSELAPGGRGPTRSLPAGELPASWRDAALRAGEVFGLEVY
                     GVDVLDAGGGAPLLVDVNAFPGIRGQAGAPEALAELALQTAANGRPTTTGETKLPEVSQ
                     K"
     gene            complement(13248..14219)
                     /locus_tag="CPH93_RS15810"
                     /old_locus_tag="SAMN06272775_3228"
     CDS             complement(13248..14219)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604223.1"
                     /locus_tag="CPH93_RS15810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3228"
                     /product="hypothetical protein"
                     /protein_id="WP_096213225.1"
                     /sec_met_domain="RimK (E-value: 2.7e-08, bitscore: 32.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLCFLVEEQYRHDGMPLDVIRQLGAWGHQVDVLWPGRSLISLSD
                     AIQAGSHDAWVLKTVSGGPGLTLLEAAASAGLTTVNDVRAIRGVRDKALAAVIARGTGL
                     PVPVTYAAARPEELAEIPEAEFPLVVKPADGSSGRAVRLVATPDRLLEPMAPGDCAGGL
                     LIAQPYVPNSGTDLKVYSVAGELYATERCSPLHPAHDVRERQVPLTAEVARIAARIGEV
                     FGLDLYGVDILLGPDGPVVVDINDFPSFRQVPDAVARVSAAVLELARRGTSGRDAAPAA
                     GRVALPAAGRVTGQPNAGAATTRSVTPLPRPARPTAPLGGGR"
     gene            14480..14989
                     /locus_tag="CPH93_RS15815"
                     /old_locus_tag="SAMN06272775_3229"
     CDS             14480..14989
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604224.1"
                     /locus_tag="CPH93_RS15815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3229"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_093484326.1"
                     /transl_table=11
                     /translation="MTSKAAPFDELDRKIIAALIDNGRASFAEIGGAIGLSATAVKRRV
                     DRLRESKVITGFSATVRPSALGWLTEAYVEVYCDSAAPPRRLAEVVRNHPEIAAAMTVT
                     GGADALLHVRATDVEHFEEVLERIRAEPFIRKTISYMVLSHLLPESPEAGARGSFEPSD
                     AENVQK"
     gene            15112..15927
                     /locus_tag="CPH93_RS15820"
                     /old_locus_tag="SAMN06272775_3230"
     CDS             15112..15927
                     /EC_number="3.5.3.18"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010988508.1"
                     /locus_tag="CPH93_RS15820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3230"
                     /product="dimethylargininase"
                     /protein_id="WP_231977361.1"
                     /transl_table=11
                     /translation="MSVLTSRVPRPRRFLVCEPRHFDVHYAINPWMRTDAPVDTALAAR
                     QWEALMCAYRAHGHTVETVPPVPGLPDMVFAANSALVLAGRVFGSLFHAPQRRPESTAY
                     ETWFKAAGFDVYRPESVCEGEGDLVPAGPYVLAGTGFRTTRAAHQEVQEYFGVPTISLQ
                     LVDPYFYHLDTALFVLDEENIAYYPEAFSPGCREVLARLFPRAVLATRADAMAFGLNSV
                     SDGRHVFIAPQATGLIGRLTTEGYVPVPVDLSEFHKAGGGIKCCTQEIR"
     gene            15927..17162
                     /gene="rocD"
                     /locus_tag="CPH93_RS15825"
                     /old_locus_tag="SAMN06272775_3231"
     CDS             15927..17162
                     /EC_number="2.6.1.13"
                     /GO_function="GO:0004587 - ornithine aminotransferase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (37-358). E-value: 2e-102.
                     Score: 334.6. Matches aSDomain:
                     nrpspksdomains_CPH93_RS15825_Aminotran_3.1"
                     /codon_start=1
                     /gene="rocD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089890.1"
                     /locus_tag="CPH93_RS15825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3231"
                     /product="ornithine--oxo-acid transaminase"
                     /protein_id="WP_096213227.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.2e-115, bitscore:
                     385.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPTRIAPVLAPRSSAELIQAEGPVLAHNYHPLPVVVARAEGVW
                     VEDVEGNRYLDMLAGYSALNFGHRHPALIEAAHRQLDQLTLTSRAFHNDRLAGFAEGLA
                     ELTGLDMVLPMNTGAEAVESGIKVARKWAYDVKGVPADRATIVVAGGNFHGRTTTIVGF
                     SDDDEARAGFGPFAPGFRTVPYNDLAALEAAVDETTAAVLIEPIQGEAGVLIPDDGYLT
                     GVRELTRRTGCLFIADEIQSGLGRTGKTLAVEHESVVPDVLLLGKALGGGIVPVSAVVA
                     RREVLGVLGPGQHGSTFGGNPLAAAVGSAVIELLATGEFQRRAADLGERLRTGLAALTG
                     KGVTGFRSRGLWAGVDIDPALGTGREISERLLKEGILVKDTHGSTIRLAPPLTITAEEL
                     DGALNSLGRVLG"
     aSDomain        16038..17000
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPH93_RS15825_Aminotran_3.1"
                     /evalue="2.00E-102"
                     /label="CPH93_RS15825_Aminotran_3.1"
                     /locus_tag="CPH93_RS15825"
                     /protein_end="358"
                     /protein_start="37"
                     /score="334.6"
                     /tool="antismash"
                     /translation="VARAEGVWVEDVEGNRYLDMLAGYSALNFGHRHPALIEAAHRQLD
                     QLTLTSRAFHNDRLAGFAEGLAELTGLDMVLPMNTGAEAVESGIKVARKWAYDVKGVPA
                     DRATIVVAGGNFHGRTTTIVGFSDDDEARAGFGPFAPGFRTVPYNDLAALEAAVDETTA
                     AVLIEPIQGEAGVLIPDDGYLTGVRELTRRTGCLFIADEIQSGLGRTGKTLAVEHESVV
                     PDVLLLGKALGGGIVPVSAVVARREVLGVLGPGQHGSTFGGNPLAAAVGSAVIELLATG
                     EFQRRAADLGERLRTGLAALTGKGVTGFRSRGLWAGVDID"
     gene            17528..18265
                     /locus_tag="CPH93_RS15830"
                     /old_locus_tag="SAMN06272775_3232"
     CDS             17528..18265
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (66-171). E-value: 5.7e-11. Score:
                     33.0. Matches aSDomain: nrpspksdomains_CPH93_RS15830_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604227.1"
                     /locus_tag="CPH93_RS15830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3232"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_096213228.1"
                     /transl_table=11
                     /translation="MDRNIRTIEDVLTLLDGLFTPEADRWTADGASWWDGFYADRAKPV
                     PFFVAKPDENLVSCLDRGLLTPGRALDLGCGPGRNALHLAAAGFEVDAVDLSPAAIAWA
                     QDRAAETKAEVRFLCGDAFTLADTALAGPYDLIYDSGCFHHLPPHRRLSYLALLDRSLA
                     PGGHLALTCFAAGAMGSELDDRDFYRHSGLQGGLAYTPDSLREIFSHLTELELRRMHDE
                     PPDSPHFGEPFLWTAVFRREDGR"
     misc_feature    complement(17529..17543)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.56"
                     /tool="antismash"
     aSDomain        17726..18040
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPH93_RS15830_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="5.70E-11"
                     /label="CPH93_RS15830_oMT.1"
                     /locus_tag="CPH93_RS15830"
                     /protein_end="171"
                     /protein_start="66"
                     /score="33.0"
                     /tool="antismash"
                     /translation="PGRALDLGCGPGRNALHLAAAGFEVDAVDLSPAAIAWAQDRAAET
                     KAEVRFLCGDAFTLADTALAGPYDLIYDSGCFHHLPPHRRLSYLALLDRSLAPGGHLAL
                     T"
     misc_feature    complement(18353..18365)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.24"
                     /tool="antismash"
     gene            18478..18792
                     /locus_tag="CPH93_RS15835"
                     /old_locus_tag="SAMN06272775_3233"
     CDS             18478..18792
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538937.1"
                     /locus_tag="CPH93_RS15835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3233"
                     /product="type VII secretion target"
                     /protein_id="WP_093484322.1"
                     /transl_table=11
                     /translation="MAHEKFTAHPDKLRNLSHDFKHVESRLEGQVNQFAKKAENVDEAF
                     GVLSESTEALAKYVEMTRATVKNLQQLHQQLAGYAAGLDRTAANYEHTDVQQAAAFKGE
                     "
     misc_feature    18523..18525
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18795..19904
                     /locus_tag="CPH93_RS15840"
                     /old_locus_tag="SAMN06272775_3234"
     CDS             18795..19904
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141425.1"
                     /locus_tag="CPH93_RS15840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3234"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_096213229.1"
                     /transl_table=11
                     /translation="MAEQQQEIEKSFNILKPGGNPEVLRTCAAAWREMARDLQVSGRDL
                     DQQVADLAEADWSGRAATGFREHWTHTKQQLDHAVPNFERVAKELEQAADHIEDANEQV
                     QHVLEELAVTAAVGLGLTVITAGFSDAVAAGAAAAEVAEAGTVVARLAKLLKTVESALE
                     SLRTLMESSKLLKIGVEFGTNVTGNFTGNVLGQVFTGQEVTWGQDFQDAAVAGGVGTAL
                     GAGGRAIGGKMSGALGKAFEGDGFWGKTATGAATSAGGQMAADGLDIHQGSKTTDNLIP
                     DLITSAGGGAAGGAAVHGGEARYEHGGGGRHRDPDTGPTFGPGRQAAANGVVYGDANAN
                     ETDRTAEHPTSPFDQPRSALTDPDGAYDS"
     misc_feature    complement(19978..19992)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.73"
                     /tool="antismash"
     misc_feature    complement(20042..20051)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     misc_feature    20149..20167
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            20152..20523
                     /locus_tag="CPH93_RS15845"
                     /old_locus_tag="SAMN06272775_3235"
     CDS             20152..20523
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CPH93_RS15845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN06272775_3235"
                     /product="hypothetical protein"
                     /protein_id="WP_159395006.1"
                     /transl_table=11
                     /translation="MYSVAVLTLPTSLPDTSVSVGTVVYRLRSEPLPPRAGVPVHLPQG
                     RRPRMIKCSVDPAFAKLVITEPVVRITAGAHMGWRLHGNQMIGWLKGSKPYGKIVGLAE
                     TMADVLAEFPASALSGDSP"
     gene            complement(20596..21177)
                     /locus_tag="CPH93_RS15850"
                     /old_locus_tag="SAMN06272775_3236"
     CDS             complement(20596..21177)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604228.1"
                     /locus_tag="CPH93_RS15850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3236"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_096213231.1"
                     /transl_table=11
                     /translation="MEHDEARTRILDAAEKLFYDRGIQSVGMDELRSTAGVSLKRLYQC
                     FPAKHDLVEASLRRRDTRWRTALTAYVTEHADTPEARPLAVFDWLHDWFTAPDFRGCAF
                     INSFGELGATSDGVARVAREHKHALLSYLTDLARDARAPEPAAMGGQLAVLVDGAITTA
                     ALTGDPSAARQARTAAAALLAAARTATAPG"
     misc_feature    complement(21200..21213)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.02"
                     /tool="antismash"
     misc_feature    complement(21234..21247)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.48"
                     /tool="antismash"
     gene            21277..21735
                     /locus_tag="CPH93_RS15855"
                     /old_locus_tag="SAMN06272775_3237"
     CDS             21277..21735
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134804.1"
                     /locus_tag="CPH93_RS15855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_3237"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_096213232.1"
                     /transl_table=11
                     /translation="MPSRPPFPPFDEASARQKVQAAEDAWNTRDPERVALAYTEDSVWR
                     NRDTFLAGREEIVGFLRQKWARELDYALRKELWSYDGNRIAVRFQYECHDAAGQWWRSY
                     GNELWEFDEEGLMRRREAGIHDVAITEAERRIFGPRQEEEKGRAIPFR"
ORIGIN
        1 tggcccggtc gagggtgccg aggaggttga gcagcgtgga ttttccggag ccggacgggc
       61 cgacgatggc gagcagttcg ccccgcgcca cccgcaggtc cacgccgcgc agggcgtgga
      121 cgccgcccgg atacgacttc gtggccgccc gcagttcgat cactgctgag gtcattgctc
      181 ggccgctccg accttcatgc cctcggccag tccggccccg ctgacctcga tccggccgtc
      241 ggccgacaga ccggtttcga cctgcaccat gtgcgacgtg gcgccctgga cgacctccag
      301 gccgtagccg ccctcgcgca gcgcgacgac cgcctcgacc ggaaccgtca gcacgtcctt
      361 gcggctctcg ctgacgaact tcacgctcag ggtgccctgt tggtccttct gctggggctt
      421 ggcgctgccg tcgagcgtga tctcgacctc gacgtcctct ccggacggcg caccggaacc
      481 gctgggggcc gcgccctcgg cggagtccgt gctctcgggg gtggccacgc cggtgacctt
      541 gccgcgccgg gtgcctccgc tgggcatagc gatctccacc ttggtgccgt tggcggccag
      601 cgcccggtcg gcggcgtcga gcgaggcccg gacgacgggc ttggtggagg cgaccgtcag
      661 caccttgtcg gacggaccga ccgcgtcggc gagggcggcg tcggcggcca ccacgcgtac
      721 cgggccgcgc tggaagacga tgtccccctt gccgaccttg ccgttcgcat ccgtgcggcc
      781 gagggacttc tgccacgcct tgacggcggc ctcggtcgcg gtgtcatagc gggcgtccac
      841 atacagccgg gagccgaagc ccaggtcacg gaggttgcgt tccagttgga ggacgtccgg
      901 gccgcggtcg cctgccttca tcgcgcggaa catcggggtc gcgccgtaga ggaggaccac
      961 cggccgggcg tcccgctcgt acagcggctg gccgagcgac acggtgcgcc ccggccgggc
     1021 ggccttggtg accgtgccct ccacggggga cttcactgca cggcgctgtg cgtagtcgag
     1081 atctccgtcg acggtcttgc tcaccaccag atcggtgcgg gtgatctcgg tcgtgtgggc
     1141 cggccccctg gcgcgcccgc cgtcggccgc ggcgtccttg ccgttgttgg tgaggaggat
     1201 gacgccgccg gtcgccgcgg tcgcggtgac cgccgcgagc agggcgatca gcccccggcg
     1261 gcgctgtgcg gtgcggctca ctgcatgccg tccagtccgt cgaggagctt gcccttgcac
     1321 gcctggcggg cctgcttgta cgcgggcgag tcctcggaca cctcgggcga gacggggttc
     1381 gcgtcgccgc ccgggatgac attgccgtcc tggagctgcg ggttggcgaa cttcgaaagg
     1441 ccgtgggcgc gcatgcactt ggcgtgcgcg agcatcgact cgtattcctt ctggacgtcg
     1501 cggcgcggct cctcctgcat cgccttgcgc atgtcgtcgg tgcagacacc gcccttaccg
     1561 cccttggcga tctcttcgtt gcccggcttc tcctggagtt cgtcgatctt cgtccagtcg
     1621 agatagccgc tcagcttggg gtcggggaag tccttgtcga cgttcttgcg catgcactgg
     1681 acgtacttca tctgcgcgtc gtagaacgcg ctcttgccct gggccgcgga gctcgcggag
     1741 ccggagccgt ccttgttccg gtcggtcgag ggcgcgtggc tgacggaggc cacaccggcg
     1801 tccgacgact gggtgccacc gcaggcggtg gtcagggcga gggtgggcac ggccaccagc
     1861 agcgcgaggc gcgcggtccg ggaacggggg aaagtctgcg gggtcatgcg gccaatttcc
     1921 ggccgctagt tggtggtctt tccatggccg catgatggga acgtaacaat gcctccggac
     1981 cgcacccccg ccctgtggat aactcctgag ctgcacggac gtcgcacata atcggccgca
     2041 tgcctcatgt actgctggtc gaggacgaca cgtccgtgcg cgacggaatg gagctggtgc
     2101 tgcgccggca cggccatgcg gtcgacgccg tcgccaccgg cgaggaaggg ctgacgctgc
     2161 tgtcccggcc gcgcggcggc ggcatcgaga tcgcggtggt cgatctgatg ctgccgggca
     2221 tcgacggctt cgaggtctgc cggcgcatcc gtgcccggag ccagctgccg atcatcatgc
     2281 tcacctcgcg cggggacgat ctggacgtgg tcagcgggct ggaggcgggc gccgacgatt
     2341 acgtgatcaa gccgatcacc ggccgggtgc tggaggcccg gatccgggcg gcgctccgcc
     2401 gggccgggcc ggccacccgc accgacagcg acgacttcgc cgggctggtc atcgaccggg
     2461 ccggtctgac cgtcaccaag cacgacgccc ccgtgcccct cccgcccacc gagctgcggc
     2521 tgctgctgga gctgtccgcc gcccccggcc gggtcttcag ccgcgaacaa ctcctcgaac
     2581 tcgtctggga acacgacttc ctgggcgact cccggctggt ggacgcggcg gtgggccggc
     2641 tgcgcgccaa gctggaggac gtccccgcca gaccgcgcta catccagact gtgcgcggct
     2701 tcggctatcg cttcggaccg ctgtgagcgg gcgatgacca ccactgcgag gaccgcaccc
     2761 aagctcgccg cgacgacggg tgcgcgccgc gcggcggcgg cccgggtgcg gctgccgcac
     2821 atcggcggtc tgcgcggccg gctcatcgtc accgtcgtcg tggtcgccct gatcagcgcg
     2881 gtcaccgcca ccggcctggc ctaccgggaa tcgcgcgagg ccgtcctcaa gcgggcccag
     2941 agcgccgccg tcgacgactt ccgcaaccgc atcgagcggc tcgcgccgga gctcgacgtc
     3001 cccaccgacc gccgggcgat ggcccgcttc gcccaggacg tctcgtccgg gctgcgcggc
     3061 tccctggtcg tcgcccggta ccgcgaactc accgccgtca ccgacccctc cgccgaccgc
     3121 acccgcatca cccccgaact ccgcgcggcc gtacgcaccc actcccgggt ctcggtccag
     3181 cgggtggagc agggcggacg gccctggctg gtcctcggcg ccccggtcgg cctcgacgca
     3241 ccgaccccgc acggcagttc ggccgggccg tccggggtcg agatctacgc ggtcgtctcc
     3301 ctggcggagg aggaacgcga caccgccgag ctggtgcgca gcgtgcaggg cggcctggtg
     3361 cccgtggtgc tgctggccgc cgtactcgcc ctgttcgcgg cccgtacggc gctgcggccg
     3421 gtccgcagac tggcgcgcgc cacccgccgg ctggccaccg gcgagctgag catccgggtc
     3481 gaggagaagg ggcgcgacga actcgccgag ctggcgcaca ccttcaacga gacggccggc
     3541 gcgctggaac acagcgtcgg cgagctgcgc gaacaggagg cccgggcccg gcgcttcgtc
     3601 gccgatgtct cccatgagct gcgcaccccg ttggccgcca tgaccatggt ctccagcgtc
     3661 ctggaggagg acgccgacga actcaccccg gacaccgcac acgccgcccg tacggtcagc
     3721 gccgagaccg ccaagctcgc ccggctcgtc gacgacctca tcgagatatc ccgcttcgac
     3781 gcccgggccg tggcgctcac cgtgcacgaa ctggacctgg ccgaggcggt gcgcgccacg
     3841 ctggctgccc gcggctggag cgaccgggta gaggccgatc tccccccggg catacgggcg
     3901 cggctcgacc gccgccgtct ggacgtcatc gtcgccaacc tcgtcggcaa cgccctgcgg
     3961 cacggcgcac cgcccgtgac cctcaccgtg cgggcggccg atgactggct gaccctcgcc
     4021 gtcgccgacc acggcccggg gctggccccc gagaccgccc gccatgtctt cgaccgcttc
     4081 tacaaggccg acagcgcccg cacccgctcc gagggcagcg gcctggggat ggccatcgcc
     4141 ctggagaacg cccgtctgca cggcggcacc atcgagatcg cgcccccggc gcccggcgtc
     4201 ggcgcggtct tcaccctccg cctccccctc cgtacggact ccgcctcatg atgcgccccc
     4261 gccccgccgc cgtctgctgt ctgctcgccg ttgccgccac ggggtgcggc atccgcccca
     4321 ccggcgtcac ggacggcggc aaggctccct ccgggatctc ccagggcatg cgggtctact
     4381 tcgcctccga cagcggcccc cgcggggtgt cccggcccgg tgccaagatc gacgacctca
     4441 acgacgcctt caagctgttg ttggcaggcc cgacctccga ggagcgcgcc gccgggctgg
     4501 ccaatctgat cagccgggac ggggcgtaca gcgccacctc ccgccacggc aaggtcaccg
     4561 tcaacgcccc ggaccgctat ttcggccctc aggaccagag caccggccaa ctggtctgca
     4621 ccatcgcccg ggccgaggtg ctgttgcacg acacccgtcc ggacaaggtg caggtgacca
     4681 tcatcggcgc ggacggtcgt gccgggccgt accagtgcca gcagttcctg tcgcggtgag
     4741 ggccgagggc gcgtgcactg gtcgggcacg cagcggccgg tggttggctg gtcgggctcc
     4801 cgcctgccgc ctgccgcctg ccagttgggg gtgcgggctt ggggccggcg aggcgggctg
     4861 gggctgcgag ccgtaggggc ggagtcgggc gcgaaatggc ggctgggggc tgggagccgc
     4921 tggtcgcagc tactccggag ccacggacaa cagccggtag ccgtcgccct ccgggatcac
     4981 ccgtcctgcc gtgggcggcg ggaagtggct gcccaggagc agggtgtcgg taccggcgag
     5041 cgaggtgagc agggcgcggc gggtgtgctc ggcctgtacg ggatcgacgt cgacgcagct
     5101 gccgatgccg gggcgcagca actggaccgg gtggtgaatg cagtccccgg tgatcagggc
     5161 cgtctgtccg gcgctgcgca gctccacggc gacctggccg ggcgtgtgtc cgggggtggg
     5221 cagcagacgc acgccgaggg cgatgtcggt gccctcggcc gggacctcga cgaggtcgag
     5281 cagtccggcg tcgcggaccg ggtggaccga gtcccggaac atctggcgac gggcctcgtc
     5341 catctcggcc ccggcccagt ggtcccactc cgcgcgggag gtcagatagc gggcgcgggg
     5401 gaaggtggga acccaactcc ctttgtcggc acgggtgttc cagccgacgt ggtcggtgtg
     5461 cagatgggtg agcacgacca ggtccacctc ctccggggca aacccggccg cggtcagccg
     5521 ctggaggtag tcggtgtcga ggtcgtgcca ggcggggttg gcccggggtt tgccgttgcc
     5581 gattccggtg tcgatgacga tgcgcaggcc ctgcacctcc acggcgaaac tgtgaccggc
     5641 caggcggagg gctccggcgt cgtcggcgaa gtccggccgg agccatgggg cttgggccac
     5701 cacctccggg gtggcgtcgg gcagcagcca gcgtccggtc tgcgcgggga aggccacctc
     5761 gtcgatgcgg cggacggtga ggtcgcccac cgtccaggcg ggggtggtgt cactgaaggc
     5821 gggcatggat catcctctca caggcaaaag caaacccttt gcgttaagtc acactagccc
     5881 gctatgctga gctaacgcaa acaaatagct tttgctgttg tcgatgtggg gaggttgtcg
     5941 gcgcggcaac cgacgcggct gccgctcccc aaccccctcg ccccctcacc cccctcgcgc
     6001 tccccaccat gccccatcgc tccgttgtcg gcatgcacgg accgggaaga gatgcgcaga
     6061 ccacgaaggg atgcgcagga ccacgaagtg caggaccacg aagtgcagga ccacacagcg
     6121 ccggaccaca cagcgccgga caccgcagtg ccagatcacg aaaggccgtg catgaccacc
     6181 gcagaactca ccccgcagga aagcgcccgc tgggcgctcc gcgccggact ccccctggcg
     6241 gacgaccgcc tcgcccccgt gaccgacacg gcgaaccaca tccagtccgt cctcggcgtc
     6301 ctgcgtgagc tggacttccg gcagacaccc ccggcccccg tctaccaggc aggagggccc
     6361 gtcggtgcag ccgtatgagt tgacgctggc cggcgcggcc accgccatcc gggcgggaga
     6421 gctctccccc gtggagctga ccgagtcggt gctcggccgg atcggtgcgg tggaggaccg
     6481 tctgggggcg tacgtcaccc tcgccgcgga ctccgcgcgc cggtcggccg tacgggcgga
     6541 gcgggagatc gcggcgggcc gccatcgcgg ccccctgcac ggcatcccgt tcggactgaa
     6601 ggacctcatc gatgccgccg ggcttcccac gacggccagt tcgcgggtcg gggcgccgca
     6661 cccgccggcc acggacagcg ccgtggccgc ccgactgtcg gccgccggcg ccgtcctgct
     6721 gggcaagacc cacacccatg aattcggcta cggcctgacg acgccgcaga cccgcaatgc
     6781 gcgcgaccac gaccgtatcg ccggcggatc gagcggcggc tcggccgtcg cggtggccgc
     6841 gggagccgcc accttcgccc tcggtacgga caccggcggc tccatccggg tccccgcggc
     6901 gctgaacggc gtggtgggcc tcaagcccac ctatggcctg ctcccgctgc agggcgtgac
     6961 ctcgctgtcg tggtcgctgg accacgtcgg ccccctgacc cgcaccgtcg aggacgccgc
     7021 cctggtgctc accgccctgg tcggcaatca gggcccgccc ggcgccccgg gcgcggcgga
     7081 caccccagcc ctcaccggcc gcagcgtcac tccggccgcg ccccgggcgg acctcccgcc
     7141 cccggagagc gccgatctga cggggctgcg catcggcatc ccccgtcagc actacttcga
     7201 gcgggtggac cccggcgtgg aggcctcggt acgggccgcc atcgaccaac tgcacgcatg
     7261 cggcgccgag ctcatggaca tcgacatccc gctggcccgc tacctccagg cgacccagtg
     7321 ggggctcatg gtgcccgagg cgaccgccgc ccacgaacag acgctgcgct cggtgccgga
     7381 gctctacggc gaggacgtcc gggtcctgct ggaggccggc gcactcgtcc cggcgggcga
     7441 ctatctgcgc gcccagcgct cccgcgccct gatgcgcgag gcctggaccg agctgttcca
     7501 gcaggtcgat gtggtcgccg cacccagcgt gccgatggcc gccgtcaagg ccggacagca
     7561 gaaggtgcag tggccggacg gcacggtgga ggccgtctcc gacgcctacg tcaggctctg
     7621 cgcaccggcc aacatcaccg gcatccccgc cctgtccctg cccgtcggcc cggacggcac
     7681 ggggctgccg gccggcctcc agctgatggg ccggcccttc gacgaggcca ccgtgctgcg
     7741 ggtgggccgc gcctacgaaa ccgcgtccgg cagcgtcggc ggaccggttc cggtggccgc
     7801 ctgatgcgcc cgcccggccg cccggcgtac ctgaagcgcc accccggcgg cgggcttccg
     7861 agagcccctc cccactccct cttgatgcaa ctccttcgcc ttaagccgta aggtggagcc
     7921 atgagcccca ggccgatgac ccgccccggg ggacgcagcg cccgcgtcca ggaatcggtg
     7981 cacgccgccg tgcgtgccct tgaggccgaa cagggccgcg acgcgctgac cgtgcccctg
     8041 gtcgccgccc gcgccggcgt caccccgtcg acgatctacc gccggtgggg agacctccag
     8101 gaactgctgt ccgacgtggc cgtcgagcgc ctccgcccgg agacggagcc cgccgatcac
     8161 ggagcgctgc gcaccgacct ggaggcctgg gcagagcagt tcctggagga gatgtcctcg
     8221 cccccgggcc gtgcgtacat ccgcgatgcg ctcgccggtg atccggacgg cagccatgcg
     8281 ggtcagtgtt cggcctacgc cgccgagcag gtggacatca tcctcgcccg cgccgccgac
     8341 cgcggcgaac aggccccgga cgccgaggtg gtgatggacc acatcgtggc cccgatgatg
     8401 taccggctcg tcttccggcc gggcccgctg gacgcgtcgt acgcccacgg cctggtcgag
     8461 gcgacgctgt ccagcctgat gccacccggc tgaccgcagg gcgaaaggcc cgcctcaccc
     8521 agccgaccgc ccctgcctct gcccgtggac ctgccgctgt ccgtgcccgt ggaccggctt
     8581 gtgtccgtgg acctgcttat gtccgtggac ctgcgcctgc ccctgcgccc cgtccgccgc
     8641 atgtgtgcca tccgggtcgt ccgggttctg cgggctctcc tggttgtcgg acggctcggc
     8701 actgtcggac gggtcgccat tgtccgacgg gtcgccgttg tcggacgggt cggcgctgtg
     8761 cgacgggtcc gggtcgccgg agggctcggg gctgtcggag gggtcggggg catcggcggg
     8821 atccgcttcc cgcgggccgt ccgagctgag ccggaggctg ccgaaccgtg cgttgcgcca
     8881 gtcgcggtgg ggcacgacgg tgaccacgga gccggtgcaa tcgcggccgt tgtacagcac
     8941 gaggtcggtg ggggtgtcgt tgtccaccgt gccgtagccg tcccccactc cgtagcaatg
     9001 gtcgtcgccg ggatcgagga tctcgtgcgg ccggttctcc gggcgggtgt ggtacgtgat
     9061 gacgccggtg acggcctggg cgccatgggg gctgaaggcc acgaacgccc cggtgagggc
     9121 cagggcgcca aggaaagcag tcatgcgtcg cacagtcgga actcctcgtc agccacgggc
     9181 ggcggtccga acggcccggg tccggccctt acgggatgtc gccaagtggg gttcccgacg
     9241 ccccctcagg atattcacct catacgggat attcaccgtg cagcgggaca tggagggagg
     9301 cgtccggcgg ctgaccggcg tggctcccgg ggccggtgag tgcgccgtac gggtaccgcg
     9361 cggagcggct atcttgcggc ggtgaccggt tccgcggcgc gcccgctgct cttcctcgac
     9421 gtcgacggcc cgctcctccc gttcggggga gctgcggagg accgcgcggg cgggcatccg
     9481 gcgtacccgg cggcgggcca cctgcccccg ggcgccggtg cgaacccgct gctgggccgg
     9541 atcaaccccg cgcacgggcc caggctggcg gcgctgccgt gcgagctggt ctgggcgacc
     9601 acctggatgc acgaggcgaa cgagtacctc gcgccgctgc tcgggctgcc ggaactgccc
     9661 gtgctgagct ggccggaatc gtccgccgag gaggaccggg atgtgcgcgc cgggctgcac
     9721 tggaagaccc gcgcgctcgt cgaccgggcg gccggccgcg ccttcgcctg ggtcgacgac
     9781 gagatcaacg accgggaccg ggcctgggtg gcggcacacc acggcccccg ggccctgctc
     9841 ctccgcgtcg atccccggtg cggcctcacc gacgcggact tccgcctcct gcacgactgg
     9901 ttgcgcaggg tgggaggaga gggaggggca ggagaggcgt gaaggggccg cgcgcgagcc
     9961 ggaactgcct ccggccccgc ggcccacccc gcccggcgct ctaccccacg cccaccccca
    10021 ccgccgaccg gaagagccgc gccgccgacg tccccaagcc gctcggtgcg cccagccagc
    10081 ccggcgcccc cgtcggataa cgcagctcgg gctcgatgta gcgccggcag ccccggtgcc
    10141 agatgaggat gccggccatc cagttctcca gctcctggac gtatccgtcg agcgccttgc
    10201 gggcctccgg ggagaggtcg aagtcgtcgt agacgacggg gagttgatgg gccgcgacgt
    10261 gccggaactc gttcatgcgg gaggtcatga ggtcattgat gatgtgcagc gcggtcgggt
    10321 agtcgcagtc gaagaaggtc tggacgacca ggatgccgtt gtggacctcg ccctcgtact
    10381 cgatctcctt ctggtacgag aagacgtcgt tcatcaggca ggcgaagtcg gcggcggagt
    10441 tctccagtga gcgcagggcg ccggtgcggt agacctccgg cgggacctgc cggccgtggc
    10501 cgatgcggct caggctcatg gtgaggtcgg agccgaaggt cgcccggcgc atctcgacgt
    10561 agtcgaccgg gtcggggatc cggttctgga tctggttgtc gatctcccag agccagctgg
    10621 ccgtcatcgt gtcgacggac tggcggaacg cccggcgcgc ctcgggggtc atcggccccg
    10681 ccgtacggga ccacaggtcc gccagcccgc gttcgagggc gttgaccggc tccggggcgg
    10741 gggccgagag gtcgaggggc atgaacgacg acagccgctc ggtgcacacc ttggcggccg
    10801 gcaggtcgcg cggccgcccg aagacctgcg ggtagtagtc gtccgcatag gtgccccagg
    10861 ccagccatgc ggcgctgagg tccagttggt cggcggtggc gtcggggtgg atgccggccg
    10921 cgcacagcgc cagatcgtgc cggatcatcg cgggctcgtc ccagacgtcg gacagcggca
    10981 cgccgggctg cggccgcagg atgcccatcc ggtgcgccca ctcgacgacc cggcggcggg
    11041 cgccctccag atgcgggctg agggtggtgg tgaacggcat gtggatatcg gggatgcggg
    11101 acggaccgac cttccggtgc ggcacatgcg tggtgctgcg cagacggtgc gcaccggccg
    11161 tggccagggc gcgccgcaga tccgcggccg aggtgccgag tccgccgagg gggtacggcg
    11221 accaggcggg cgaggtgcgg gccgcggacc cgccgccgtt catgtagcgg ctggagcgca
    11281 tgtgccattc atggccgccg gactgccagt cctggagccc cttggcgtac gccagcacgt
    11341 ccgcgcagga cttggggtcc agacccttct cggcgaagag cgcggggagt tccccgacga
    11401 cggtgttctc gaactgctgc aaccgcgagg tgatcaggtc gttgacggag tccgcggcct
    11461 cctgggtggt gcactgcagg aaggtctcca gcaccaggac gccgttgctc agctcgccct
    11521 cctcctccgt ctcccgctgg taggagaaga ggtcgttgcg cagatggacg ccgtcggaga
    11581 aggtgtcgcg cagcacccgc agcggccggg acccggcgac ggcggcgggg acctcggcgc
    11641 cggtcgcgta ctccaccagg cccgccgacc agggcgcccc accgaccttg cggcgcatct
    11701 cgatgtactc gacggggttg ggcacccggt ggatgtcgat attggacagt tcccagagcg
    11761 actcgttgag cagatgctcg gtgctctcgg cgaaccgccg ccgccagtcc atggacatgt
    11821 gcggcacggt gcgcgcccac aggtcggcca ggcccgcctc gacggggttg accggctcgg
    11881 gaacgggcgc ggtcaggtcc atcggcatga aggccggcag ccggtcgagg tacgccttgc
    11941 cgccctcgcg gtccagcgtc cgcttgaact tctccaggaa gtggtcgtcg aagaagaaga
    12001 cccacacgta ccagtcggtc accagcgaga gcgcgtcggc gtcacagtcc gggtgggtgt
    12061 aggaacacag cagggcgtag tcgtgggcgt cgaggtccgg ctcctcccag atgccggagc
    12121 cctccagcat tcccatgctg cgcgcccatg tcctggagtg cgtacgggcc gcctccagat
    12181 gcgggttcag ccgcgccgga tagggcgtgt agaaggtggg caattcgaat ggctgctgcg
    12241 acaccgttgc tggcctcttc ccctgcgtac ggaaggacgg cgcgccgatc cacgcccccc
    12301 ttgaacgggg gcagcgctac cccggtggtc ggcggcttag gccttatgga ggaggagctt
    12361 ccgcctccac gccgcttcgg ttcggagtgc gttgaactgg gcttatttct ggctgacttc
    12421 tggcagcttt gtttcgcctg tggtggtcgg acggccgttc gccgccgtct gcagggcgag
    12481 ttccgcgagc gcctccgggg cgccggcctg gccgcggatc ccggggaagg cattgacgtc
    12541 cacgagcagc ggcgcgccgc cgccggcgtc gaggacgtcc acgccgtaga cctccaggcc
    12601 gaagacctcg ccggcccgca gcgcggcgtc ccgccagctc gcgggcagtt cgccggccgg
    12661 cagcgagcgg gtcggtccgc ggccgcccgg ggccagctcc gagcggcgca gcccggcgaa
    12721 gagccggccg tcgaccaccc acagcttgtg gtcccagccg ctgttcgcgg tgaactcctg
    12781 gaccaccacc ggctccgctg cccagtccgc ggccagctcc cgcagccggg cggcgctgtc
    12841 ggcgcgggcc accaggtcgt ggcgccggct gaaccggctc ttgagcacca gcggagtggc
    12901 cggatcgccg gcggccgcca gccggccgac cgtggtcagc gccgtggtgg cggcgaacgg
    12961 cagcccggcc gcgcgcgcca cgtcggccat cgcgacgcgg tcctggcagc gcgcggtcgc
    13021 cgctgcggag ttgagcaccg gggcgccgtg ctcctccagg aaggcggcga gcgccagcgc
    13081 ccgcggggtc cgcgccttga gcagatagac gtccgcgagc gggaagaggg cggggcccgc
    13141 ggtggcactg cccgggtcca gcgaaacgac ctcgtgctcc ggggccagca gcgcggtgac
    13201 ggcggccagc agcggatggc cggggtcggc ggtgagcaga cagatcctca tcggccgccg
    13261 ccgaggggcg cggtgggccg ggcggggcgc gggagagggg tcacggagcg cgtcgtggcg
    13321 gcccccgcat tcggctgccc cgtcacccgt ccggccgccg gcaaagccac ccgcccggcc
    13381 gccggagccg cgtcccgccc gctcgtcccg cgccgggcga gctccagtac ggcggcggac
    13441 acccgggcga ccgcgtccgg cacctgacgg aagctgggaa agtcgttgat gtcgacgacc
    13501 accgggccgt cgggcccgag caggatgtcg acgccgtaga ggtcgaggcc gaagacctcg
    13561 ccgatccggg cggcgatccg ggcgacctcg gcggtgagcg gcacctgacg ttcgcgtacg
    13621 tcgtgcgcgg ggtgcagggg cgagcaccgc tcggtcgcgt acagctcacc ggcgacgctg
    13681 tagaccttca gatccgtacc ggagttgggg acgtagggct gggcgatgag cagcccgccg
    13741 gcgcagtcac ccggcgccat gggctccagc agccggtccg gcgtcgccac cagccggacc
    13801 gcgcgcccgg aactgccgtc cgcgggcttg accacgagcg ggaactccgc ctcgggtatc
    13861 tccgcgagct cctccggccg ggccgccgcg tacgtcaccg ggacgggcag ccccgtaccg
    13921 cgggcgatca ccgcggccag cgccttgtcg cgcaccccgc ggatcgcccg gacatcgttc
    13981 accgtcgtca gcccggcgga cgccgcggcc tccagcaggg tcagtcccgg gccgccggag
    14041 acggtcttga gtacccacgc gtcatggctg cccgcctgta tcgcgtcgga cagggatatc
    14101 agcgagcggc cgggccacag cacgtccacc tggtggcccc aggcgccgag ttggcggatc
    14161 acatccagcg gcatgccgtc gtggcggtac tgctcctcca ccaggaagca gagtctcatg
    14221 gggcaccctc gtcatcgccg cacgtccgtc caccgtccgt ccggcagatc catgacgtac
    14281 caggatccca tgcggggatc gggcagtgcc gtgggcccac gcgcccggca acccgggccc
    14341 gcgcgcgggc ggctgaccta ctggcacacg gcggggcggg ccgagccgcc ccgcgcgtcc
    14401 ggtgtcgcta ccgtgaggcg accgcggccg cccgggacca ggcaggacgg agcgggaccg
    14461 ggatgcaatg ggaggtccag tgaccagcaa ggccgcgccc ttcgacgagc tcgaccgcaa
    14521 gatcattgcg gcgctgatcg acaacggccg ggcgagcttc gcggagatcg gcggggcgat
    14581 cgggctgtcg gccaccgcgg tgaaacggcg ggtggaccgg ctgcgggaga gcaaggtgat
    14641 cacggggttc agcgccaccg tccggccgtc cgcgctgggc tggctgaccg aggcgtacgt
    14701 cgaggtgtac tgcgacagcg ccgcaccgcc ccgccggctc gcggaggtcg tacgcaacca
    14761 tccggagatc gccgcggcga tgaccgtcac cgggggcgcc gatgcgctgc tgcatgtgcg
    14821 ggcgaccgat gtcgagcact tcgaggaggt actcgaacgc atccgggccg aaccgttcat
    14881 ccgcaagacg atcagctaca tggtgctgtc ccacctgctg ccggagagcc cggaggccgg
    14941 cgcccgcgga tccttcgagc cgagtgacgc agaaaacgtg cagaaataac ggctgaaacg
    15001 cagcattgct gcgcggatac gcagcatttg ttgcttgttg ccggaatccc tcgctccgta
    15061 ccgtggaaaa cacgaggtga caacccttaa cggtctgtca tggcaggagg gatgtctgtg
    15121 ctgacgagtc gtgtgccgcg cccgcggcgc tttctggtgt gcgaaccccg gcacttcgat
    15181 gtgcactacg ccatcaaccc ctggatgcgg acggacgcac cggtcgacac cgcgctcgcc
    15241 gcccgccagt gggaggccct gatgtgcgcc tatcgcgcgc acgggcacac ggtggagacc
    15301 gtgccgccgg tgcccggcct gccggacatg gtgttcgcgg cgaattcggc gctggtcctg
    15361 gcggggcggg tcttcggctc gctcttccac gccccgcagc ggcggccgga gtccaccgcg
    15421 tacgagacgt ggttcaaggc cgccggcttc gacgtctacc ggcccgagtc ggtgtgcgag
    15481 ggcgagggcg atctggtccc ggcgggcccg tatgtgctgg ccggcaccgg attccgcacg
    15541 acgcgcgccg cccaccagga ggtgcaggaa tacttcgggg tgccgaccat cagcctccag
    15601 ctggtggacc cgtacttcta ccacctcgac accgcgctct tcgtgctcga cgaggagaac
    15661 atcgcgtact acccggaggc cttctcaccc ggctgccgcg aggtgctcgc ccggctcttt
    15721 ccccgtgcgg tgctcgccac ccgggccgac gccatggcct tcgggctcaa ctccgtctcc
    15781 gacggccgcc atgtgttcat cgccccccag gcgaccggcc tcatcggccg gctcaccacc
    15841 gagggctacg tccccgtccc cgtcgacctg tccgagttcc acaaggccgg cggtggcatc
    15901 aagtgctgca cccaggagat ccgctgatga ccgctcccac tcgcattgcc ccggtgctcg
    15961 ctccccgttc gtccgcggag ctgatccagg ccgagggccc ggttctcgcg cacaactacc
    16021 acccgctgcc cgtggtggtc gcgcgcgccg agggcgtctg ggtcgaggac gtcgagggga
    16081 accgctacct cgacatgctg gccggctact cggcgctcaa cttcggccac cggcacccgg
    16141 cgctgatcga ggccgcccac cgccagctgg atcaactcac cctcacctcc cgcgcgttcc
    16201 acaacgaccg gctcgccggc ttcgccgagg gcctcgccga gctgaccggc ctggacatgg
    16261 tgctgccgat gaacaccggc gccgaggcgg tggagagcgg catcaaggtc gcccgcaagt
    16321 gggcgtacga cgtcaagggc gtcccggcgg accgggcgac gatcgtggtg gccggcggca
    16381 acttccacgg ccggacgacc accatcgtcg gcttctccga cgacgacgag gcccgcgccg
    16441 gcttcggtcc cttcgccccc ggcttccgca ccgtccccta caacgacctg gccgcgctcg
    16501 aagcggccgt ggacgagacc acggccgccg tgctgatcga gccgatccag ggcgaggccg
    16561 gtgtcctgat ccccgacgac ggctacctca ccggcgtccg cgaactgacc cgccggaccg
    16621 ggtgcctgtt catcgccgac gagatccagt ccggcctggg ccgcaccgga aagaccctgg
    16681 ccgtcgagca cgagtccgtc gtccccgacg tgctcctcct gggcaaggcc ctcggcggcg
    16741 gcatcgtccc ggtctccgcg gtcgtcgccc gccgcgaggt gctcggcgtg ctcggccccg
    16801 gccagcacgg ctcgaccttc ggcggcaacc ccctggcggc cgcggtcggt tcggccgtga
    16861 tcgagctgct cgccaccggc gaattccagc gccgcgccgc cgacctcggc gagcggctgc
    16921 gcaccggcct ggccgcgctg accggcaagg gcgtgaccgg cttccgctcc cgcggcctgt
    16981 gggcgggcgt ggacatcgac cccgccctcg gcaccggccg cgaaatcagc gaacgcctcc
    17041 tgaaggaagg catcctggtc aaggacaccc acggctcaac gatccggctg gccccgccgc
    17101 tgaccatcac cgcggaagaa ctggacgggg cactcaactc cctgggacgg gtgctgggct
    17161 aggcccccct gtcatctgtc tttgcttccg agccgccggg ctgcctcgca cgacaggggc
    17221 gcgcccggcg gctcggctcg gttcggttcg gctcggttcg ctcggctcgc tgaaaaaccg
    17281 tccccggcgc gctcgtaaac acccccgtga cgcccctgga cagcacccga acggcgcccc
    17341 acccggccca tggtcggtcc ccctccccac cctcacgcgc gcccctctca caccccgcaa
    17401 cgacctcccc tccaccccac ctgacctggg ctgatgcggc gttcccgact acgctcaccg
    17461 caccggcaaa ggcggaccgc atggaccggc aaaccgggac cacagggacc ggatcaaggg
    17521 ggaccacatg gaccggaaca tccgcaccat cgaggacgta ctcaccctcc tggacggcct
    17581 gttcaccccg gaggccgacc gctggaccgc cgacggagcc tcctggtggg acggcttcta
    17641 cgcggaccgc gcgaagccgg tgccgttctt cgtggcgaag cccgacgaga acctggtctc
    17701 ctgcctggac cgcggactgc tcaccccggg acgcgccctc gacctgggct gcggccccgg
    17761 ccgcaatgcg ctccacctcg ccgcggcggg cttcgaggtg gacgcggtcg acctctcccc
    17821 ggcagccatc gcctgggccc aggaccgcgc cgcagaaacg aaggccgagg tccgcttcct
    17881 ctgcggcgac gccttcaccc tcgccgacac cgcactcgcc ggcccgtacg acctgatcta
    17941 cgactccggc tgcttccacc atctgccgcc gcaccgccgc ctgagctacc tcgccctgct
    18001 cgaccggtcc ttggcccctg gtggccacct cgccctcacc tgcttcgccg ccggcgcaat
    18061 gggctccgaa ctcgacgacc gcgacttcta ccgccactcc ggcctccagg gcggcctcgc
    18121 ctacaccccg gactccttgc gcgaaatctt ctcccacctg acggaactcg aactccgccg
    18181 catgcacgac gagcccccgg actcccccca cttcggcgag ccgttcctgt ggacggccgt
    18241 cttccggcgc gaggacggcc ggtagctttc cgccgcggag atggtcggct ctccgtagcg
    18301 gagacagtca ctccgaaggt gctccaccgc caagccggtc tttacctttc gcttgcccat
    18361 tgcattcgca ggttttgaat ctcttgttgg cttcttgacg cgacagcact gcagttcagc
    18421 cgcaccagcc gatagcgtgt tttcgatggc cgatcatgca gcaacgggga gcggaatatg
    18481 gcgcacgaga aattcactgc ccatccggat aaactccgca acttatctca cgacttcaag
    18541 cacgtagaaa gccggcttga aggccaggtc aaccagttcg ccaagaaggc agagaacgtt
    18601 gacgaagcgt tcggtgttct cagtgagtca accgaggcat tggccaagta cgtggagatg
    18661 acgcgggcca cggtaaaaaa tctccagcag ctgcaccaac aacttgcggg gtacgcggcg
    18721 ggtctggacc gtactgcagc gaactacgag cacacagacg tgcagcaagc ggccgcgttc
    18781 aagggggagt gaccatggcc gagcagcagc aggagatcga gaaaagcttc aacatcctca
    18841 aacccggcgg caatccggag gtgctgcgca cgtgcgcagc ggcatggcgg gaaatggccc
    18901 gtgatctcca ggtatcggga cgagatctcg accagcaagt cgcagacctg gcagaggcgg
    18961 actggagcgg ccgggccgct accgggttca gagaacactg gacgcacacc aaacagcagc
    19021 tcgaccacgc agtgcccaac ttcgagcgag tggccaagga actggaacag gccgctgatc
    19081 acatagagga cgccaacgag caggtacaac acgtccttga agaactggcg gtcactgcag
    19141 cagttggcct gggcctgacc gtcatcaccg caggcttctc cgacgcggtg gccgcgggag
    19201 ccgcggcggc cgaagtcgcc gaggccggca ctgtcgtcgc gcggcttgcc aaactcctca
    19261 aaaccgtcga gtcggcgttg gagagcctcc gcaccctcat ggagagcagc aagctcctga
    19321 agatcggcgt ggaattcggc acgaacgtca ccggcaactt cacggggaac gtgctgggcc
    19381 aggtgttcac cggccaggag gtcacctggg gtcaggactt ccaggacgcc gcagtggccg
    19441 ggggcgtcgg cacagcgctc ggagcgggag gccgggcgat cggtgggaag atgtccggcg
    19501 cactcggcaa ggcctttgaa ggcgacggat tctgggggaa gacggccaca ggtgcggcca
    19561 ccagcgcggg tgggcagatg gctgccgacg gcctcgatat ccaccaaggc agcaagacaa
    19621 ccgacaacct catcccggac ctgatcacca gtgccggcgg cggcgcagct ggcggagcgg
    19681 cggtacacgg tggcgaggcc cgctacgagc acgggggagg cggacggcac cgcgaccccg
    19741 acaccggccc taccttcggc cccgggcggc aggcggccgc caatggcgtc gtctacggag
    19801 atgccaacgc caacgagacc gaccggaccg ccgaacaccc tacgagcccg ttcgaccagc
    19861 cacgttccgc actgaccgat ccggacggcg cgtacgacag ctgaggagac cgcaatcatg
    19921 tggcgggtca gtaggagtgt ccgcagatat cgccaggccc ccgaatggca tcactaccga
    19981 aaacgtgaat cagctgactg ggtggacacg ttcggcgttc ccggccaccc cttcggcacg
    20041 ctcagaaatc acgcccagaa tgtgttggaa gggaaggtgc gaggctaccc ggcgacactt
    20101 ttccacctgt ccggggtacg caaaggcggc cgctacggca ccatcctcaa catgtattcg
    20161 gtagccgtcc tcacactgcc gaccagcctc cccgatacgt cggtctccgt cggcacggtg
    20221 gtctaccggc tccggagcga acccctcccg ccccgcgcag gagtccccgt ccacctgccc
    20281 cagggccgca gacctcgcat gatcaagtgc tccgtcgacc ccgccttcgc caagctggtc
    20341 atcactgagc cggtggttcg gatcaccgcg ggcgcccaca tgggctggcg gctgcacggg
    20401 aaccaaatga tcggctggct caaaggcagt aagccgtacg ggaagatcgt cgggctcgcc
    20461 gagaccatgg ccgacgtcct ggccgagttc cccgcttccg cactgtccgg ggactccccg
    20521 tgaactcagc gcctccctcc ggcgttcccc gcggggcagc catctcctgg tttccggcca
    20581 cggcttgcgg tggtgtcatc ccggtgctgt tgccgtccgg gcagccgcca ggagggccgc
    20641 agcggcagta cgggcctggc gggcggcgga cgggtcgccg gtgagtgcgg ctgtggtgat
    20701 cgcgccgtcc acgaggacgg ccaactgccc gcccatggcg gccggttcgg gggccctcgc
    20761 atcccgggcg aggtccgtga ggtacgagag cagggcgtgt ttgtgttcgc gggcgacgcg
    20821 ggcgaccccg tccgaggtcg cccccagttc gccgaaagaa ttgatgaagg cgcagccgcg
    20881 gaagtccggg gcggtgaacc agtcgtgcag ccagtcgaag accgcgagcg gccgggcctc
    20941 gggggtgtcg gcgtgttcgg tgacgtacgc ggtgagggcg gtgcgccacc gggtgtcgcg
    21001 gcggcgcaga gaggcctcga cgaggtcgtg cttggccggg aagcactggt agaggcgctt
    21061 gagggacacc ccggcggtgg agcggagttc gtccatgccg acggactgga ttccgcggtc
    21121 gtagaacagc ttctccgcgg cgtcgagtat ccgcgtacgg gcttcgtcgt gttccatggc
    21181 ccttccggca cttcccagga gaacggtcgt tctctatgct agccgaacga gcgagaacgc
    21241 tcgttctccg gaggtttgag agcagggagg cccgccatgc cgtcacgccc accgttcccg
    21301 ccgttcgacg aggcgagcgc gcggcagaag gtgcaggccg ccgaggacgc ctggaacacc
    21361 cgcgatcccg agcgggtcgc cctcgcgtac accgaggact cggtctggcg gaaccgggac
    21421 accttcctcg ccggccgcga ggagatcgtc ggcttcctgc gccagaagtg ggcccgcgag
    21481 ctggactacg cgctgcgcaa ggaactgtgg tcctacgacg gcaaccggat cgcggtgcgc
    21541 ttccagtacg agtgccatga cgcggccggg cagtggtggc gcagctacgg caatgagttg
    21601 tgggagttcg acgaggaggg gctgatgcgc cgccgggaag ccggcatcca cgatgtcgcg
    21661 atcacggagg cggaacggcg gatcttcggc ccacggcagg aggaggagaa ggggcgggcg
    21721 attccgttcc gctgagtgcc tcggagggcg ctcacccggc cgaggcgggg aacaccatcc
    21781 ccggcatgcg cggatgcgcc cacagtcgaa actttccgtc tggacgatgc cgggaacgag
    21841 ggaagacgca aactcgtgga tcaccgtggc cacgatgact tgagccgtcg tgcgggggct
    21901 gtcggccgaa cgggcggaag atgatgtaac ggccgtcgcc cgggctcacc tgcgggaaag
    21961 gcgatggcat gagccacgct gacgaattcg atctcctcct actgccgcgt cggacggcag
    22021 gtgggctgac gtgagggctt tcgtgctccg gaaggtcggc gaggtcggcg tcatcgagaa
    22081 gccggtcccc gagcccggtc ccaatgacgt ggtcgtgcgc accaccgcgg ccttggtgtg
    22141 cacgaccgat gtgcacgtca tgcggggcgt cattccggtt gctccggatg tgacgctggg
    22201 gcatgaggcg gtcggtgtcg tccatgcgct cggctcggcg gtcg
//
