LOCUS       NZ_LT907981            11378 bp    DNA     circular CON 12-FEB-2024
DEFINITION  Streptomyces sp. 2323.1 chromosome I.
ACCESSION   NZ_LT907981
VERSION     NZ_LT907981.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 2323.1
  ORGANISM  Streptomyces sp. 2323.1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 03:31:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,058
            CDSs (total)                      :: 6,971
            Genes (coding)                    :: 6,808
            CDSs (with protein)               :: 6,808
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 163
            CDSs (without protein)            :: 163
            Pseudo Genes (ambiguous residues) :: 0 of 163
            Pseudo Genes (frameshifted)       :: 64 of 163
            Pseudo Genes (incomplete)         :: 123 of 163
            Pseudo Genes (internal stop)      :: 17 of 163
            Pseudo Genes (multiple problems)  :: 37 of 163
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1809528
            Orig. end                         :: 1820906
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT907981.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11378
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="13"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11378
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11378
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6378](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6378
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(225..241)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.77"
                     /tool="antismash"
     misc_feature    complement(406..421)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     gene            420..890
                     /locus_tag="CPH93_RS07215"
                     /old_locus_tag="SAMN06272775_1500"
     CDS             420..890
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CPH93_RS07215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN06272775_1500"
                     /product="hypothetical protein"
                     /protein_id="WP_096212327.1"
                     /transl_table=11
                     /translation="MLDFVNPNRLQDGRECGVRLELRLSEPDTLPGSIYASRALSITRG
                     VCRFDLLESAPGAQDRMHWHPEMPNGEGRKRLYDDELARDPMGWLGRQLRDAIGLLKTG
                     GVDAAERFADDARLLARMADDIVADATDTLSRSRRTPWPPVERRDERGMALA"
     gene            887..1885
                     /locus_tag="CPH93_RS07220"
                     /old_locus_tag="SAMN06272775_1501"
     CDS             887..1885
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00745.1"
                     /locus_tag="CPH93_RS07220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_1501"
                     /product="ketopantoate reductase family protein"
                     /protein_id="WP_096212328.1"
                     /transl_table=11
                     /translation="MRALVVGAGATGGYFGGRLAEAGRDVTFLVRPGRAAQLNSRGLMI
                     RSPYGDVRLTPKLVRARELTETYDLVLLTVKAYALEQAVEDIAPAVGPGTVILPVLNGL
                     RHAELLEERYGGHRIAGGVCLVTTTLDPDGGIRQLNDRQELRYGSWRAPGPAALPKLDS
                     WLGGSGFTVRPSPAIRQEMWEKWVYVAAIGAVTCLMRGVVGEVVAAPGGADFAERVVEE
                     CAAVAAACGHPVRATALRETLATLTEPGSTAASSLYRDLLRGSAVEGDHILGDMIERGA
                     RHGLDSPLLHLANSQLCVYQRTLSPTGRIASAQPAAVTQVNAGQPAGFTEV"
     misc_feature    1796..1798
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1888..2604
                     /locus_tag="CPH93_RS07225"
                     /old_locus_tag="SAMN06272775_1502"
     CDS             1888..2604
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048753.1"
                     /locus_tag="CPH93_RS07225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_1502"
                     /product="M24 family metallopeptidase"
                     /protein_id="WP_096212329.1"
                     /transl_table=11
                     /translation="MDETVVPADIDEEVRALNLIEAERKAVALFDEVTERGIVAPGQRE
                     SEVSNQVRDLAADLFGTSKHWHKRIVRSGPNTLHPYRGNPPDRLIAAGDIVFLDFGPVF
                     SEWEADFGRTYVLGDDPEKLRLRDDLPGIWEAGRKYFETHPDITGAELYAHIVSLAEAA
                     GWAFGGPHSGHLVGEFPHELIDDDLVNSYITPSNHRPLRSTDDAGRRCHWILEIHLVDR
                     ARTFGGFFEQLLTLSR"
     gene            2617..3900
                     /locus_tag="CPH93_RS07230"
                     /old_locus_tag="SAMN06272775_1503"
     CDS             2617..3900
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034319.1"
                     /locus_tag="CPH93_RS07230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_1503"
                     /product="Nramp family divalent metal transporter"
                     /protein_id="WP_231977218.1"
                     /transl_table=11
                     /translation="MSTSTSVTSSAEGTAPQPPRALLRRARGLAMLGPAFAAAIAYVDP
                     GNFATNFAAGSDLGYRLLWVVVAANLLGMLVQVLAAKLGLATGRNLAELCRDRYPRPVV
                     WTMWVQAELVAMATDLAEVIGGAISLALLFDLPLAAGGVLITVFSFVILAFETRGKRKF
                     EALIAACLACILAGFAWNLVRSGVRPTDFMGGLIPRLPDAQGLFIAGGIVGATVMPHVV
                     HLHSDLTGRHTRETSPDGALGRRRRLLWQVRLDVFVALAFAGLANMAMLIVAAKMFHAG
                     PLEIDTLESIHAAFGTLLGGGAALAFALALLASGLASTSVGTYAGQVVMAGFLGRSLPL
                     ALRRVVTVTPALAVLAVGVDPTQALIWSQLVLSFGIPFVLIPLIGFTRDARLMGPLVNT
                     RVTTALATVLAAVVVLLNVVLVTAALAP"
     gene            3948..4610
                     /locus_tag="CPH93_RS07235"
                     /old_locus_tag="SAMN06272775_1504"
     CDS             3948..4610
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CPH93_RS07235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN06272775_1504"
                     /product="hypothetical protein"
                     /protein_id="WP_197708741.1"
                     /transl_table=11
                     /translation="MSTSTIAHGSRRPHGTGHRLLTYLAGCLVFSSGSYLFIYSDLGTD
                     PLDVFALGLLKHVQLTVGVAQALIAALCILVWAAWYRRRPVVLPFVTFFLCGSVIDLLR
                     LTDPGRFLPLPHVVLMLLATTLCAYASSLIIMSGVGIRAMDLVALAIVDKWGWPFWAAK
                     MSMEGILLGCGYLMGGPVGVGTVCFLVVVDTMIQPFMRANARVLRIPNLGMPSLEKP"
     gene            5001..6378
                     /locus_tag="CPH93_RS07240"
                     /pseudo=""
     CDS             5001..6378
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327585.1"
                     /locus_tag="CPH93_RS07240"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="DUF692 (E-value: 2.6e-94, bitscore: 314.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRLGTGIGWRPEIAAEIAELPGVDWVEVVAENICPGHLPDALRE
                     LRERGTTVIPHGVSLGLGGAERPDAGRLTALAERAAALDAPMVTEHIAFVRAGGPLTAS
                     PRMEAGHLLPVPRTRDALDVLCENVRIAQDALPVPLALENIAALINWPGEELTEGQFLT
                     ELVERTGVRLLIDVANLHTNHINRGEDPAVALDGLPLEALAYVHVAGGVERDGVWHDSH
                     AHPVTRPVLDVLAELCARTTPPGVLLERDEDFPGGGELAGELDAIRSVLKEARHVRAA"
     gene            6554..7366
                     /locus_tag="CPH93_RS07245"
                     /old_locus_tag="SAMN06272775_1508"
     CDS             6554..7366
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602444.1"
                     /locus_tag="CPH93_RS07245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_1508"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_096212330.1"
                     /transl_table=11
                     /translation="MSLLFLLVAWSAAVLSCALLCRAAVAAAHITPPAPRANAQAVPAP
                     AAAERRGSGLTLYEMAYLSGGPHRLADVVLVLMAQKRRLLLADTGWATVVDPVGTDAVE
                     RAALTAIGPEGQRRIPAVRDALVSDEAVRQVADRLETAGLALPAAVRPGISGAVRLVRG
                     AALVVLLSALATYWKAAPGADSGPVLAWFAVPLILTLGTWAAARFELHPYSDWATTAGE
                     RQLPGAAGSRSAPDSPAAPAGSLITLALRGPAALTDPTLRAALHSSGA"
     gene            7466..9139
                     /locus_tag="CPH93_RS07250"
                     /old_locus_tag="SAMN06272775_1509"
     CDS             7466..9139
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (88-503). E-value: 1e-18.
                     Score: 59.8. Matches aSDomain:
                     nrpspksdomains_CPH93_RS07250_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602445.1"
                     /locus_tag="CPH93_RS07250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_1509"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_096212331.1"
                     /sec_met_domain="PF00561 (E-value: 6.7e-20, bitscore: 70.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYGTIGSLMVTALATAPAGGVTGAAGAPPAPVAHHLRFGRCAPVE
                     HLPSSVECGTLTVPLDYAHPEGRKIHLTVSRARATARGERQGSLVFNPGGPGASSMEFP
                     LYGGLPKWSKLARAYDFVGYAPRGVGRSAPLSCQDPGEFAKAPTDSRMHPDAAFKRKKV
                     AEARAYARGCVRRAGSALPFYNSVNNARDLDMLRAALGERRLTFMGASYGTYFGAVYAT
                     LFPGHVRRMIFDSVVNPAPEQIWYRNNLDQDVAFERRWGDWLRWVARHNGQYHLGTTRQ
                     AVQRAYDTAATKLRRAPLNGKIGAGQLQSAFLKTGYNDAFWPLRAEALSGYLHGDPKPL
                     IAQALPRPAGAAAEENSAAVYTAVECNDARWPRSWRTWNRDNTEIARDAPFETWDNAWM
                     NLPCAFWPDRAESADAELDAAAHRADGPEAGGDLVNAADRTAEAAVDGALHGQRRPLDV
                     HTAPGALPPVLLLAAERDAATPYRGAVELQQRLPGSSLVTENGAGTHGIAFNDNACVTA
                     YAEAYLLRGKVPARRVYCAPRAEPVPGQQATRSQHALPGK"
     aSDomain        7730..8974
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CPH93_RS07250_Abhydrolase_1.1"
                     /evalue="1.00E-18"
                     /label="CPH93_RS07250_Abhydrolase_1.1"
                     /locus_tag="CPH93_RS07250"
                     /protein_end="503"
                     /protein_start="88"
                     /score="59.8"
                     /tool="antismash"
                     /translation="LVFNPGGPGASSMEFPLYGGLPKWSKLARAYDFVGYAPRGVGRSA
                     PLSCQDPGEFAKAPTDSRMHPDAAFKRKKVAEARAYARGCVRRAGSALPFYNSVNNARD
                     LDMLRAALGERRLTFMGASYGTYFGAVYATLFPGHVRRMIFDSVVNPAPEQIWYRNNLD
                     QDVAFERRWGDWLRWVARHNGQYHLGTTRQAVQRAYDTAATKLRRAPLNGKIGAGQLQS
                     AFLKTGYNDAFWPLRAEALSGYLHGDPKPLIAQALPRPAGAAAEENSAAVYTAVECNDA
                     RWPRSWRTWNRDNTEIARDAPFETWDNAWMNLPCAFWPDRAESADAELDAAAHRADGPE
                     AGGDLVNAADRTAEAAVDGALHGQRRPLDVHTAPGALPPVLLLAAERDAATPYRGAVEL
                     QQRLPGSSLVTENGAG"
     gene            complement(9206..9958)
                     /gene="hemQ"
                     /locus_tag="CPH93_RS07255"
                     /old_locus_tag="SAMN06272775_1510"
     CDS             complement(9206..9958)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003984746.1"
                     /locus_tag="CPH93_RS07255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_1510"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_040899851.1"
                     /transl_table=11
                     /translation="MTDASTPASAPHTPAAPEKSPNAGKKAKDLNEVIRYTLWSVFKLR
                     EVLPEDRSGYADEVEELFAQLAAKDVVVRGTYDVSGLRADADLMIWWHSESSDALQEAY
                     NLFRRTRLGRALEPVWSNMALHRPAEFNKSHIPAFLADEVARNYVSVYPFVRSYEWYLL
                     PDEDRRRMLADHGKMARGFPDVRANTVPSFSLGDYEWVLAFEADELYRIVDLMRHLRGS
                     EARMHVREEIPFYTGRRKPVAELVAGLA"
ORIGIN
        1 tacggcttcc caggacgtgc cgccagggat ggtgcaccac ctgtgcggca cgcgtcgagg
       61 aggggcgcgc cgagcactcc gcggcgcggc gcttctaccc ggccgatgaa acagccggat
      121 tcgcgctgct gtgtacggcg cggccgctgt caccgatgag tgtggtggca ggccaacacg
      181 ctgcttttcg ggagcaccgc atacggaagg gactgcccgt accgcgcgcc tgaaaggggc
      241 ggccggcgta aaacattgcc ggtgatgcgg ccgtggatca ttcacggccg catcaccggc
      301 attcctgttt tcaggccggt tccctctctt tcggcggccg ttgacatttt cggtatgact
      361 ctgttgtgct gtcggacatg cgaattcata tggcgaacag gctgtgtgta agtgtggaaa
      421 tgctcgactt cgtgaatccg aaccgtttgc aggacggacg cgaatgcgga gtccgtcttg
      481 aactgcggct cagcgagccc gataccctcc ccggctcgat ctacgcatcg cgcgcgctct
      541 ccatcacccg gggcgtatgc cgttttgacc tgctggaatc ggccccgggc gcacaggacc
      601 ggatgcactg gcacccggag atgccgaatg gcgagggccg caagcgcctg tacgacgacg
      661 agctggcgcg cgatccgatg ggctggctgg gccggcaact gcgcgacgcc atcggcctgc
      721 tgaagaccgg cggggtcgac gccgccgagc gcttcgccga cgatgcgagg ctcctggccc
      781 ggatggccga cgacatcgtc gccgacgcca cggacaccct cagccgctcc aggcgcaccc
      841 cctggccccc ggtggagcgg cgcgacgagc gcggaatggc tctggcatga gggcactcgt
      901 cgtcggagcg ggagccaccg gcggctactt cggcggacgg ctggccgagg cgggccgaga
      961 cgtgaccttc ctggtaaggc cggggcgcgc agcccagctg aactcccgcg ggctgatgat
     1021 ccgcagcccc tatggggacg tacgactgac cccgaagctg gtcagggccc gggaactgac
     1081 cgagacgtac gacctggtac tgctcacggt caaggcgtac gccctggaac aggccgtcga
     1141 ggacatcgcg cccgcggtcg gccccggcac ggtgatcctg cccgtgctca acggcctgcg
     1201 tcacgccgag cttctcgagg aacggtacgg cggtcaccgc atcgcgggcg gcgtctgcct
     1261 cgtcaccacc acgctcgacc cggacggcgg catccgccag ctcaacgacc gccaggagct
     1321 gcggtatggc agctggcggg ctccgggccc ggcagcgctg cccaagctcg actcctggct
     1381 gggcggatcc ggcttcaccg tacgcccctc gcccgccatc cggcaggaga tgtgggagaa
     1441 gtgggtgtac gtggccgcca tcggcgcggt gacctgtctg atgcgcggag tcgtcggtga
     1501 ggtcgtcgcg gccccggggg gagcggactt cgccgagcgg gtggtcgagg agtgcgcggc
     1561 cgtcgccgcc gcctgcggcc accccgtcag ggcaacagcg ctgcgcgaga cgctggcgac
     1621 gctcaccgag ccgggctcta ccgcggcctc ctcgctctac cgcgacctgc tgcgcggcag
     1681 cgccgtggag ggtgaccaca tcctcggcga catgatcgag cggggagcaa ggcacgggct
     1741 ggacagcccg ctgctccacc tcgcgaattc ccaactttgc gtataccaac gcacgttaag
     1801 cccgaccggc cggatcgcga gtgcgcagcc ggccgccgtc acacaagtca acgccgggca
     1861 gccggccggt ttcacggagg tgtgatcatg gacgagaccg tcgtcccggc ggacatcgac
     1921 gaagaggtca gggcgctcaa cctgatcgag gccgagcgca aggccgtggc gctcttcgac
     1981 gaggtgaccg aacggggaat cgtggcacca gggcagcggg agtccgaggt cagcaatcag
     2041 gtcagggatc tggccgccga cctgttcggt accagcaagc actggcacaa acgcattgtg
     2101 cggtccggcc cgaacaccct ccacccctac cggggcaacc ccccggaccg tctgatagcc
     2161 gcgggggaca tcgttttcct ggacttcggc ccggtgttca gtgagtggga ggccgacttc
     2221 ggacgtacgt acgtactggg cgacgacccc gagaagctgc ggctgcggga cgacctgccg
     2281 gggatctggg aggccgggcg gaagtacttc gagacgcacc cggacatcac gggcgccgaa
     2341 ctctatgcgc acatcgtctc gcttgccgaa gccgctggat gggcgttcgg ggggccgcac
     2401 agcggtcatc tggtgggtga gttcccgcac gaattgatcg acgacgacct cgtcaacagc
     2461 tacatcaccc cctccaatca ccggccgttg cgttccaccg acgacgccgg ccgacgttgc
     2521 cactggattc tggagatcca tctggtcgac cgtgcacgga ccttcggcgg gttcttcgaa
     2581 cagttgctga cgctgagccg ctgaaggggg aatcgggtga gcacgagcac ctccgtgacg
     2641 agctcggccg aaggaaccgc cccgcaaccg cccagggctc tcctgcggcg cgcccggggg
     2701 ctggccatgc tcggccctgc cttcgccgcc gccatcgcct atgtcgaccc cggcaacttc
     2761 gccaccaact tcgcggcagg ttccgacctc ggataccggc tgctctgggt cgtggtcgcc
     2821 gccaatctgc tggggatgct ggtgcaggtc ctcgccgcca aactcggcct ggcgaccggg
     2881 cggaacctcg ccgagctgtg cagggatcgc tacccgcggc cagtggtatg gaccatgtgg
     2941 gtgcaggccg aactggttgc catggcaacg gatctggccg aggtgatcgg cggggccatc
     3001 tccctggcgc tcctcttcga cctgccgctg gcggcgggcg gggtgctgat caccgtgttc
     3061 tccttcgtca ttctcgcttt cgagacgcgc ggcaagcgga agttcgaggc gctgatcgcc
     3121 gcctgtctgg catgcatcct tgcgggcttc gcctggaacc tcgtgcggtc gggggtgcgc
     3181 cccacagact tcatgggcgg gctcattccc cgcctgcccg atgcgcaggg gctgttcatc
     3241 gccggcggca ttgtgggcgc gaccgtgatg ccgcacgtcg tccatctcca ctcggacctc
     3301 acggggcggc acacgcggga gacgtccccg gacggcgccc tcggccgacg caggcggctc
     3361 ctgtggcagg tacgcctcga cgtcttcgtg gcgctggcct tcgcgggcct ggcgaacatg
     3421 gccatgctga tcgtcgcggc caagatgttc cacgccgggc cgctggagat cgacaccctt
     3481 gagagcatcc acgccgcctt cggtactctg ctcggcggcg gtgcggcgct ggccttcgcc
     3541 ctcgcgctcc tcgcctcggg ccttgcttcc acctctgtcg gcacctacgc gggccaggtc
     3601 gtcatggccg ggttcctcgg ccgctccctg cccctcgcac tgcgccgggt ggtcacggtg
     3661 acacccgcac tggccgtctt ggccgtcgga gtcgatccga cccaggccct gatctggtcc
     3721 cagctcgtcc tctccttcgg catccccttc gtgctcatcc cgctcatcgg gttcacccgt
     3781 gacgcccggc tgatgggtcc actggtcaac acccgggtga ccacggcgct cgcgaccgta
     3841 ctcgcggccg tcgtggtcct cctgaacgtg gtcctcgtga cagccgccct cgctccatga
     3901 ccccggggga acaccaccga ccctccctct cgcaggaagg cacatctgtg tccaccagca
     3961 ccatcgcgca cggaagccgc cggccccacg gcacgggcca ccgtctgctg acgtacctcg
     4021 ccggctgcct ggtcttttct tccggctcct atctcttcat ctactccgac ctcggtacgg
     4081 acccgcttga cgtcttcgcc ctcggtctgc tgaagcatgt gcagttgacg gtgggcgtcg
     4141 cccaggccct catcgcggcg ctgtgcattc tcgtctgggc cgcctggtac cggcgccgcc
     4201 ctgtggtcct gccctttgtg acgttcttcc tgtgcggcag cgtcatcgac ctgctgcggc
     4261 tgaccgatcc cggacggttc ctgccgctgc cgcacgtggt gctgatgctc ctggccacca
     4321 cactgtgcgc ctatgcctcg tcgctgatca tcatgagcgg ggtgggcatc cgtgcgatgg
     4381 acctggtcgc ccttgccatc gtcgacaagt ggggctggcc tttctgggcc gcgaagatgt
     4441 cgatggaggg catcctgctg gggtgcggct acctgatggg cgggcctgtg ggcgtcggaa
     4501 cggtctgctt cctggtagtc gtcgacacca tgatccagcc cttcatgcgg gccaacgcca
     4561 gggtcctgcg gatccccaac ctgggcatgc ccagcctgga gaagccctga gtgaccaggc
     4621 ccgacccagg agttctgtac ggcaacggtg cttgaggtga cgggactgca attcggtcga
     4681 ctacgtcatc gagcgcctcg gcgatccggg tgcggtgctg atcgtggacg acaccgggtt
     4741 cctgaggtgc tcagaggtgc aacatcctgg tcccggccga gctcgccccc ggctcctgca
     4801 cggtcgtggc cggccacccg gcgctgcgta gcgcgttgcc gcccaccggc tgaggccgcg
     4861 gggcccgccc gggcgcgggc ggatactgga cggcgggcgc cgccgccggt gaagctcaaa
     4921 tcaacctctg aaccggccgg tacaggattc gggccaccgt accgggtcag gagtaccccc
     4981 accacggaag agggggagcc atgcagcgcc tggggacggg aatcgggtgg cggccggaga
     5041 ttgctgccga gatagcggag ttgcccgggg tggactgggt cgaggtggtg gcggagaaca
     5101 tctgccccgg tcatctgccg gacgccctgc gggagctgcg tgagcggggc accaccgtca
     5161 tcccgcacgg ggtctcgctc gggctgggcg gcgccgagcg tccggacgcc gggcggctga
     5221 ccgcgctcgc cgagcgcgcc gcggcgctgg acgccccgat ggtcaccgag cacatcgcct
     5281 tcgtccgggc cggcgggccg ctgaccgctt cgccgcggat ggaggcgggg catctgctgc
     5341 ccgtcccccg cacccgtgac gcgctggacg tgctgtgcga gaacgtgcgg atcgcccagg
     5401 acgccctgcc ggtgccgctg gcgctggaga acatcgccgc gctcatcaac tggcccggcg
     5461 aggaactgac cgagggacag ttcctgaccg agctggtcga gcggaccggg gtgcggctgc
     5521 tcatcgatgt cgccaacctc catacgaacc acatcaaccg gggcgaggat ccggcggtgg
     5581 ccctggacgg gctgccgctg gaggccctcg catacgtcca tgtcgcgggc ggtgtggagc
     5641 gggacggggt gtggcacgac agtcacgccc acccggtgac ccggccggtg ctggacgtac
     5701 tggccgagtt gtgcgcccgg accaccccgc ccggcgtgct gctggagcgg gacgaggact
     5761 tccccggggg cggggagctg gccggcgagc tcgacgcgat ccgtagcgtg ctgaaggagg
     5821 cccgccatgt ccgggccgca tgagccggag gccgggccgg cggcacgggc ccgcggccgg
     5881 cgggcggcgg aaggggccac cgccgctccc gccaccgctc cccccgccac ggacaccacg
     5941 accgaagcag acaccacgac cgacgccgca cggcagcgac tggcgctggc gcagaccgcg
     6001 ctgctgtcgg cgctggtcgc cgggacgccg gcccccgagg gcttcgaccg cgcccggctc
     6061 cgggtgcaga gccgggcgct gaccgccaag cgggccgatg tcgtcgccaa ggtcgcgccg
     6121 gagctgcccg gcatcctcgg cgcggactac cgggccgcgt tcctcggcta tgcgcgccac
     6181 cgccccatga gcggcggcta ccgccaggac gccctggagt tcgcggcgta tctgctggac
     6241 cgggggcgtc ccgaagacgc ggacgcacgg cggcagttgc ggcactggtg gcgggatcgc
     6301 tcggggccgc gcccgccgtc cgcgcgaccc ctggcccggc tggcgcgcat ggtgcggcag
     6361 ctcctgcccc cgaggtaacc gcggcgcccc gcccaggacg gcgtggtgcg ggccgtccaa
     6421 gagggcacag cacgccccac ccaggagggt gcggtccggg ccgcgccgtc ggaacgtgcc
     6481 gtaccgcgga aggctgcccg catcctgaga aacgttgtgg cggtaagcag gcccgtaccg
     6541 tagaaaaccg gctatgtcgc tcctcttcct ccttgtcgcc tggtcggcag cggtgctgtc
     6601 ctgtgcgctg ctgtgccgtg ccgcggtcgc cgccgcccac atcaccccgc cggccccgcg
     6661 ggcgaacgcc caggccgtcc cggctccggc cgccgcggag cgccgcggct ccgggctgac
     6721 cctgtacgag atggcctacc tttccggcgg accgcaccgg ctcgccgacg tggtgctggt
     6781 gctgatggcg cagaagcggc ggctgctgct cgccgacacc ggctgggcca ccgtcgtcga
     6841 tccggtcggt acggacgccg tcgagcgcgc cgccctcacc gcgataggcc ccgaagggca
     6901 gcgccgcata ccggccgtac gggacgccct ggtgagcgac gaggcggtgc ggcaggtggc
     6961 ggaccggctg gagacggcgg ggctggcgct gccggccgcg gtccggccgg gcatcagcgg
     7021 tgccgtccgc ctggtgcggg gcgccgccct cgtggtgctg ctgtccgccc tcgcgaccta
     7081 ctggaaggcg gcgcccggcg cggacagcgg gcccgtcctg gcctggttcg cagtgccgct
     7141 gatcctcacc ctcggcacct gggccgcggc ccgcttcgag ctccacccgt acagcgactg
     7201 ggccaccacg gcgggcgagc ggcagctgcc cggcgcggcc ggctcccgca gcgcccccga
     7261 ctcccctgcc gccccggccg gctcgctcat cactctcgcc ctccgcggcc ccgccgccct
     7321 caccgacccc accttgcgcg ccgcgctcca ctcatccggg gcatagcctc cgacaccgga
     7381 cccaggtgct ttacatcgac aatgcgcgcc ccaactatcc cttttgtatg cacacacgaa
     7441 gggacggcca gtgagagcac ttgcgttgta cggcaccatc gggtcgctga tggtgaccgc
     7501 cctcgccact gccccggcag gcggcgtcac gggggccgcc ggcgcgccac ccgcaccggt
     7561 cgcgcaccac ctccgattcg gccgctgcgc accggtggaa catctgccgt cgtccgtgga
     7621 gtgcggcacg ctcaccgttc ccctcgatta cgcgcacccc gagggaagga agatccacct
     7681 gaccgtcagc cgggcccggg ccaccgcgcg cggtgagcgg cagggctccc tggtcttcaa
     7741 ccccggcggc cccggcgcgt ccagcatgga gttcccgctg tacggcgggc tgcccaagtg
     7801 gagcaagctg gcgcgcgcct atgacttcgt gggctatgcg ccgcgcggcg tcggccgctc
     7861 ggcgccgctg tcgtgccagg accccgggga gttcgccaag gcgcccaccg acagccggat
     7921 gcaccccgat gcggccttca agcgcaagaa ggtggcggag gcgagggcgt acgcccgcgg
     7981 ctgcgtccgc cgggccgggt ccgcgctgcc cttctacaac tccgtcaaca acgcccgcga
     8041 cctggacatg ctgcgggccg cgctcggcga gcggcggctg accttcatgg gcgcctcgta
     8101 cgggacgtac ttcggtgcgg tctatgcgac gctcttcccc ggtcacgtcc ggcggatgat
     8161 cttcgacagc gtggtcaacc ccgcccctga gcagatctgg taccgcaaca acctcgacca
     8221 ggacgtcgcc ttcgagcgcc gctggggcga ctggctgcgc tgggtcgccc ggcacaacgg
     8281 ccagtaccac ctgggcacca cccggcaggc ggtgcagcgg gcctacgaca ccgccgccac
     8341 gaagctgcgc cgcgcgcccc tcaacgggaa gatcggcgcg ggccagctgc agtcggcctt
     8401 cctcaagacc ggctacaacg acgccttctg gccgctgcgc gccgaggcgc tctcggggta
     8461 tctgcacggc gaccccaagc cgctgatcgc ccaggccctg ccccggcccg cgggtgccgc
     8521 cgccgaggag aacagcgccg ccgtctacac cgccgtcgag tgcaacgacg cccgctggcc
     8581 gcgcagctgg cggacctgga accgcgacaa caccgagatc gcccgggacg cgccgttcga
     8641 gacctgggac aacgcctgga tgaatctgcc gtgcgccttc tggcccgacc gggcggagtc
     8701 ggccgatgcc gagctggacg ccgcggcaca ccgggcggac ggccccgagg ccggcgggga
     8761 tctggtgaac gccgccgacc gtacggccga ggccgcggtc gacggtgcgc tgcacggtca
     8821 gcgccgcccg ctcgacgtcc acaccgcgcc gggggcgctg ccgccggtgc tgctgctggc
     8881 cgccgagcgg gacgcggcga cgccgtaccg gggcgcggtg gagctccagc agcggctgcc
     8941 cggctcctcg ctggtcaccg agaacggggc gggcacccac ggcatcgcct tcaacgacaa
     9001 cgcctgtgtg accgcgtacg ccgaggcgta tctgctgcgc gggaaggtcc cggcgcgccg
     9061 ggtgtactgc gcaccgcggg ccgagccggt gcccggccag caggcgaccc ggtcgcagca
     9121 cgcgctaccg ggcaagtagc cggggagcag acgctgcggg ccgtccccga gggggcggcc
     9181 cgcagtgctg tgctccggcc gtggatcagg ccaggccggc gaccagctcg gcgaccggct
     9241 tacggcgacc ggtgtagaac gggatctcct cgcggacgtg catccgcgcc tcggagccgc
     9301 gcagatggcg catcaggtcg acgatgcggt agagctcgtc ggcctcgaag gccagcaccc
     9361 actcgtagtc gccgagcgag aacgacggca ccgtgttggc gcgcacgtcc gggaagccgc
     9421 gggccatctt gccgtggtcg gccagcatcc ggcggcggtc ctcgtcgggc aggaggtacc
     9481 actcgtagga gcgcacgaag gggtagacgc tgacgtagtt gcgggccacc tcgtcggcca
     9541 ggaaggccgg gatgtgcgac ttgttgaact cggcggggcg gtgcagcgcc atgttcgacc
     9601 acaccggctc cagcgcacgg cccagacggg tgcggcggaa gaggttgtac gcctcctgca
     9661 gggcgtccga gctctccgag tgccaccaga tcatgaggtc ggcgtcggcg cgcaggccgg
     9721 acacgtcgta cgtgccgcgg accaccacgt ccttggccgc gagctgcgcg aacagctcct
     9781 cgacctcgtc ggcgtagccg ctgcggtcct ccgggaggac ctcgcgcagc ttgaagaccg
     9841 accagagggt gtagcggatg acctcgttga ggtccttggc cttcttgccg gcgttcgggg
     9901 acttctcggg cgccgcgggg gtgtgcggcg ccgaagcggg ggtggaagcg tctgtcatgt
     9961 cgtccattct cactcgcccc gggcccggtc cgccgtcagg gtcccgagga tctcgtccgc
    10021 ggcgcggtgc gccgagccga tgcaggccgg gatcccgacg ccgtcgtaga ccgcgccgca
    10081 cacccgcagc gcacccggca tccgggcgac cgcggcgcgg atcttggcga cccgctccag
    10141 atggccgacg gcgtactgcg gcagtccgcc ctcccagcgg gtgacggtgg cggccaccgg
    10201 gcgggcggtc aggccgaccg ccgcgccgag gtcggcgagg gagagcgcga ccagctcgga
    10261 gtcgtcgcgc tggaggtcgg catcgtcctg gtagcggccg agggaggtgc gcagcacgaa
    10321 caggtcgggg tccgcgtcgc cgacccagcc ccatttgtgg ctggagaagg tcgaggcctt
    10381 gatccggcgg ccgtcgacgg gcggcacgag gaagccgctg ccggcgggca cccggtccag
    10441 gtcggcgcgg cggaaggcca tggtgaccag cgccatcgag gcgtagtcga cggtggccag
    10501 ctcggcggcc gcggccgggg agtcctggcc caggaggtgc gccgcggcgc ccgccggtgc
    10561 ggccatgacg accgcgtccg cggtgagcgt ccggtcgccg agccggatgt gccagccgtc
    10621 gtccccggcc cagtgcagct cgtccacggc ggccccgcag cggatctcgc cgccggcccg
    10681 gcgcacggcg tcggcgacgg cggccggcag ggtcccgatc ccgccgtcga tgcccatgaa
    10741 gaccggggcg gcctgcccgt tctgcggggc ggtggcggcg gcgcgcgcct ggaggtcccg
    10801 tacgccctcg gtcagggagc gccgggtgcg ggcgacctcg aagagctgcg ggacggcggc
    10861 gcgcatcgag atgcggtagg cgtcacccgc gtagacgccg ccgagcaggg gctcgacgag
    10921 ccggtcgacg acctcccggc cgagccgggc ggcgacgtac tcgccgaccg cgacgtcctc
    10981 gccggtctcg gtccgggcca gggtctcgtc ctgggcgatc cgcgccatgc cctccgggga
    11041 gatcacaccg gaggcggcga gcggggcgag gtccccgggc acgcccatga catggccctt
    11101 gggcatcggg cgcagcgcgt cgcgggtcca cagggccgcg gtggcggtgg ccggcggctg
    11161 cagccggccg ccgatcccga cggcgcgggc gagctccacc gcctccgggc gccgggcgag
    11221 catcgactcg gcaccgagat cgaccgggac gccggcgatc tcgcccgcgt acagcttgcc
    11281 gccgagccgg ccggacgcct ccaggacggt cacccgggcg ccgccttgga gcaggcggtg
    11341 cgcggccgcc agcccggaga tgcctccacc gatgacga
//
