LOCUS       NZ_LT907981            10921 bp    DNA     circular CON 12-FEB-2024
DEFINITION  Streptomyces sp. 2323.1 chromosome I.
ACCESSION   NZ_LT907981
VERSION     NZ_LT907981.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 2323.1
  ORGANISM  Streptomyces sp. 2323.1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 03:31:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,058
            CDSs (total)                      :: 6,971
            Genes (coding)                    :: 6,808
            CDSs (with protein)               :: 6,808
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 163
            CDSs (without protein)            :: 163
            Pseudo Genes (ambiguous residues) :: 0 of 163
            Pseudo Genes (frameshifted)       :: 64 of 163
            Pseudo Genes (incomplete)         :: 123 of 163
            Pseudo Genes (internal stop)      :: 17 of 163
            Pseudo Genes (multiple problems)  :: 37 of 163
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 957921
            Orig. end                         :: 968842
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT907981.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10921
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="7"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10921
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10921
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5921](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5921
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    145..159
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    374..389
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.74"
                     /tool="antismash"
     gene            complement(426..1616)
                     /locus_tag="CPH93_RS03480"
                     /old_locus_tag="SAMN06272775_0744"
     CDS             complement(426..1616)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601753.1"
                     /locus_tag="CPH93_RS03480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0744"
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_231977165.1"
                     /transl_table=11
                     /translation="MNSVLYPLCAAVAGLALLYKLRVLRTDRSVTQVALLANFFFLFVT
                     YTVSTPAVWAATSSAVGIVNFSGLLSQSCVILLTACQQIVLLHLSHEAPVAWRKARPRL
                     IGLGLVLAAMVALFAVATSRGEKPDDFAIDSAQYYPAYLALYLVAYAANQVDVGILGWR
                     YARIAPHPWMRRGLYLIAATLPFALIYTGCRAADIVAAQFGVGGQAWEPVAQVAVTIAT
                     LSKTLGWILPDWGRHLSALWERFTDYRAFRELGPLHREVTSQIPEPVLHLEPDTDLRTR
                     LYRRLVEIRDAQWALRVWIPADVADTTAERARAAGLAGTDLAATVEAAQLRAALEARAA
                     QRRPAVHPPTPRVAEPQDLAAELAFQRKLARAFTTSPIVRAAAAQPAAGPATQERT"
     gene            complement(1609..2181)
                     /locus_tag="CPH93_RS03485"
                     /old_locus_tag="SAMN06272775_0745"
     CDS             complement(1609..2181)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017885.4"
                     /locus_tag="CPH93_RS03485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0745"
                     /product="ImmA/IrrE family metallo-endopeptidase"
                     /protein_id="WP_096211902.1"
                     /transl_table=11
                     /translation="MVLRWRHKDADPQATRLREQCERRVDALGLPAHTKLSVDDLCAHL
                     SRGSGRPIQLLPCPLPLGSPDGLWVSTPSTEYVVYEQRLAPVHQQQVILHELGHLICDH
                     ESSPVLTPEASRLLLPSLDPALIRRTLGREHARSWAETEAEYVGSLIGRRIGSWTADHV
                     RPVPPAMQELVSRLGALDNPAFRGSNE"
     gene            complement(2181..2681)
                     /locus_tag="CPH93_RS03490"
                     /old_locus_tag="SAMN06272775_0746"
     CDS             complement(2181..2681)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004940786.1"
                     /locus_tag="CPH93_RS03490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0746"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_006601755.1"
                     /transl_table=11
                     /translation="MDRHELARAAGTSAGPDGAAHAAKTAIARRLRHIRHHHPEGPFTL
                     ARLAELAGVSKRTLAAAESADGTNLTVETLVKVAHSLGVSRVAYFLDEQVFDDVNSELE
                     LLRKMRTHRVESVALRQTGPAAPDSSLTELSHLITRLVSTAEAARATLEDLPGQGRNDR
                     SPQ"
     gene            complement(3061..3996)
                     /locus_tag="CPH93_RS03495"
                     /old_locus_tag="SAMN06272775_0747"
     CDS             complement(3061..3996)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CPH93_RS03495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN06272775_0747"
                     /product="hypothetical protein"
                     /protein_id="WP_159394956.1"
                     /transl_table=11
                     /translation="MAADRSSYLSGSRRERIPFLVAQGKPAQNTALHTLVPVAAHKGAT
                     GAQEAPFGIGAAWQLGESLYTQVQDNSTGRLAVFATRGSGHIERVTGYTWNVGPVWRLL
                     TGPAAPRDLWSQLRYEHFLRHSPVADHVPECPHHCGGSEPSPAAADASPCDEAPAQPWP
                     RDGDPLEELWEESCPKGSAAQRLQEGAELLRRRVAHLLADCPVPPLHERPHAEHLDAEL
                     SHQLLRAYDALRGALALHCPWQSGWLGSWAYGIAEELIWRSRLGAARSEAERTARESMA
                     VESALSSPWPLPAPHICPGLHTVHDEAPGI"
     gene            complement(4242..4901)
                     /locus_tag="CPH93_RS03500"
                     /old_locus_tag="SAMN06272775_0748"
     CDS             complement(4242..4901)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601757.1"
                     /locus_tag="CPH93_RS03500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0748"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_093487190.1"
                     /transl_table=11
                     /translation="MYVQIRAKTTRRFLLEAAAALFDERGYAGTSISDISAHSGRTSGA
                     IYFHFASKEKLALAIVEEHFATWPQLITRYRKPGLPALERLVGLSFDVARAFRDDIVVR
                     AGSRLWAERKAIETELPAPFLDWIDAVTQLLEEAGDNGELAAGVPPAATAHSVVCAFFG
                     LHTVSDALEGRRHIEAHLHDLWLLLLRGLQAEPDPAGLLDRVRRRARTGRPAPEPA"
     gene            5001..5921
                     /locus_tag="CPH93_RS03505"
                     /old_locus_tag="SAMN06272775_0749"
     CDS             5001..5921
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543192.1"
                     /locus_tag="CPH93_RS03505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0749"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_231977166.1"
                     /sec_met_domain="AfsA (E-value: 1.6e-14, bitscore: 52.4,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSTAGTAGKSEPLSWSRTVERELVHRTSVAEVLLTDVRRTDTP
                     HVFAAAASWPRAHATFPRDGAPRHSPLILVETLRQLGLYIPLRFYAVPAACHAVITDLY
                     FRLAPGKEPPARAGATEVTCRARVSAVRRDPDRRVTGLRLDAAFTVCGLAFGQGGGGVR
                     FLSDAQYGALRGRSARVGMVTPAPEAAYRPPAAELSVNHPQDAVLAVAGGRLLLSPADP
                     LHPFLFDHPTDHVPGMALLEAARQAASYGSRGALGRPRAGRMKAVRFTELAPPARVLCT
                     QYDSTCVFRVTQGDTRTAYGTLSYS"
     misc_feature    5982..5997
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            6147..6866
                     /locus_tag="CPH93_RS03510"
                     /old_locus_tag="SAMN06272775_0750"
     CDS             6147..6866
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006601759.1"
                     /locus_tag="CPH93_RS03510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0750"
                     /product="HAD family phosphatase"
                     /protein_id="WP_093487188.1"
                     /sec_met_domain="HAD_2 (E-value: 1.4e-25, bitscore: 89.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAHRFFSWTPAAVVFDCDGTLMDTERHWQDARDMVLREYGCTPS
                     AEFSEQARGLHYTECGRLMAEAADRPDLTKDMTDTLLDRFRDLVAANPTTMPGAPELVH
                     SAVQFAPLAVASNCPLEVVESCLDMAGLRDCFRHIVVPDAAIRPKPHPDVYVTAARLCG
                     VDPGDALAVEDSHCGVQAAAAAGMRVLGVGAQPGEKEQALADWWVDSLEEPTVQGWADA
                     CIPAQDTGPGGLRATGS"
     gene            complement(6957..7667)
                     /locus_tag="CPH93_RS03515"
                     /old_locus_tag="SAMN06272775_0751"
     CDS             complement(6957..7667)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558284.1"
                     /locus_tag="CPH93_RS03515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0751"
                     /product="FCD domain-containing protein"
                     /protein_id="WP_096211904.1"
                     /transl_table=11
                     /translation="MDDPITRDTTVDALERRLRDAIIDGRHPVGALLPPERELAASYGV
                     NRTTLKHAFVRLMQAGLVETRHGVGTRVRDFWRLGTAELLPSLVLRDGAWLAEIFEVRR
                     QVGVLIGELAARRATARDVAALRQQVAAVRAGGDADQVQLADAEFHRTLARATGNRVYL
                     LMTNTLLGGYLPVRQALARPFQDAAAAADRLHPVAEAVAAGDEAAARRAVEAYMTGTEG
                     LMRATDGQRPGPES"
     gene            complement(7849..9705)
                     /locus_tag="CPH93_RS03520"
                     /old_locus_tag="SAMN06272775_0752"
     CDS             complement(7849..9705)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558282.1"
                     /locus_tag="CPH93_RS03520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0752"
                     /product="GMC family oxidoreductase"
                     /protein_id="WP_096211905.1"
                     /transl_table=11
                     /translation="MNTATEGLLAALLAEDDPATVRAVAGRLDAALAAMPRATRAAMAA
                     AATAVDAAARARHGRPLARLTPDERERTVTGLVNGPGTAHLLDLVKIPVLLAAGTEFHA
                     RRTTPAARSAAPADPPLDCVPSAQWPDRQTADAVVVGSGAGGAVAARTLARAGLRVLVL
                     EEGRHHSTAEFARRTPLDRFGELYRDGGASVMLGVPGVLLPTGRAVGGTTLVNSGTCYR
                     TPDRVLARWRQDFGLPLADAPEFGRQLDEAERTLSVARQPTDVLGTNGRLALLGAERLG
                     WRADALRRNAPGCRGSCECVVGCPTGAKQSVQLSVLPDACAHGARIVTSARVGRLLVER
                     DRPGGPRVAGVAARRPDGTTFENLAPLVVVAAGALQSPLLLRRSGLGSHPMTGRNLAVH
                     PATSVAGRFAEPVAGTPSVLQSAGVEELHDQGILLEATAPPPGLSSFVLPGAGRALRAG
                     LDRSGHLATLGAMIADRPGGRVTGRERAVSWYRLAPRDGRRLLRAVRAMGQLLLAAGAE
                     EVFTGVPGAPSVRTTRELDAVLEPVTPRQLHLSAFHPTGTVALGADARRAPADPLGRLR
                     GVRGVVFADGSALPSCPEVNPQLTIMALALAVSEAACRAAGG"
     misc_feature    9805..9817
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.18"
                     /tool="antismash"
ORIGIN
        1 ggcgaacgtc gcgaccaggt cggcctgccc caactcggcc aggcgatcgg cgaattgacc
       61 ggcggcctcg gcaacccgct cgcggagctg ctcgacgtgc cgcggggtga agcccttcga
      121 gaccagccgg cgcagccgca ggtgatcggc cgggtcgatg ttgaggaggt tggcgtccag
      181 agcgggcggc agggagaacc cctggtaacc gttcgtggaa tgggccttgt tcaccgacag
      241 ccgtgggtcg gtgagccagg cccgcacgtc gcactcccgg gtgacgagcc agacggggga
      301 cccgtcgggc agcgcgatcc ggtgcaccgg cccttcgctg cgcagccgcg cgtaggtggg
      361 gtaggggtcc tggaagaatg cctggtcgaa ggggctgctg agggtcggtg ccggggtctg
      421 ccggttcatg tgcgttcctg ggttgccggg ccggcggcgg gctgggcggc cgcggcccgg
      481 acgatcgggg atgtggtgaa tgcgcgcgcc agcttgcgct ggaaggcgag ttcggcggcg
      541 aggtcctggg gctccgccac ccggggcgtg ggcgggtgga cggcgggccg ccgttgtgcg
      601 gcccgcgcct ccagtgcggc cctgagctgt gcggcttcga cggtggccgc caggtcggtg
      661 ccggcgaggc cggccgcccg ggcgcgctcc gcggtggtgt cggccacgtc ggccgggatc
      721 cagacgcgga gcgcccattg ggcgtcgcgg atctcgacga gccggcggta gagccgggtc
      781 cgcagatccg tgtccggttc gaggtgcagc accggttcgg gaatctggga cgtgacctcg
      841 cggtgcagcg ggcccagctc ccggaaggcg cggtagtcgg tgaaccgctc ccacagcgca
      901 ctgagatggc ggccccagtc gggcaggatc cagcccagtg tcttgctgag ggtcgcgatg
      961 gtgacggcta cctgggccac cggctcccag gcctgcccgc cgacgccgaa ctgggcggcc
     1021 acgatgtcgg cggcccggca accggtgtag atgagggcga agggcagcgt cgcggcgatg
     1081 agatacagcc cgcgacgcat ccaggggtgc ggagcgatcc tggcgtagcg ccagccgagg
     1141 atgccgacgt cgacctggtt cgcggcgtac gcgaccaggt agagggcgag gtaggcgggg
     1201 tagtactggg cgctgtcgat ggcgaagtcg tcgggcttct ccccgcggct ggtggccacg
     1261 gcgaacagcg cgaccatggc ggcgaggacg agtccgagtc cgatcagccg ggggcgtgcc
     1321 ttgcgccagg cgacgggggc ttcatggctg aggtggagca gcacgatctg ctggcacgcc
     1381 gtcagcagga tgacgcagct ctgcgacagc aacccggaga agttgacgat gccgacggcg
     1441 ctgctggtcg ccgcccagac cgcaggggtg gagacggtat aggtgacgaa caggaagaag
     1501 aagttggcca gcagcgcgac ctgcgtcacg gagcggtccg tgcgcagcac gcgcagtttg
     1561 tacagcagcg ccaggccggc gacggcagca cacaaggggt agagaacgct attcattgct
     1621 tcctcggaag gcggggttgt ccagcgcacc gagccgggag accagctctt gcatagcggg
     1681 gggaacgggc cggacgtggt cggcggtcca gctgccgatc cggcgcccga tcagcgagcc
     1741 gacgtactcg gcttcggtct ccgcccagga ccgggcgtgt tcgcgcccca gcgtccggcg
     1801 gatcagagcg gggtcgagtg agggcagcag gagccgggag gcctcggggg tgaggaccgg
     1861 gctcgactcg tggtcgcaga tgaggtggcc cagctcgtgc aggatgacct gctgctggtg
     1921 caccggcgcg agccgctgct cgtagacgac gtactccgtg ctcggggtgg agacccagag
     1981 gccgtcgggg ctgcccagcg gcagcggaca gggcaggagc tggatgggcc gtccggagcc
     2041 ccggctgagg tgtgcgcaca ggtcgtcgac ggacagcttc gtgtgcgcgg gcagcccaag
     2101 ggcgtcgacc cgtcgttcgc actgttcgcg cagccgcgtc gcctgcgggt ctgcgtcttt
     2161 gtgccgccag cgcagcacca tcactgcggc gagcggtcgt tgcggccctg ccccggcagg
     2221 tcctcaaggg tcgcccgggc cgcctcggcg gtgctgacca accgggtgat gagatggctc
     2281 agttcggtca gcgaggagtc gggtgcggcg gggcccgtct gccgcagcgc cacgctctcg
     2341 acgcgatggg tgcgcatctt cctgagcagc tccagctcgg agttgacatc gtcgaagacc
     2401 tgctcgtcga ggaagtaggc cacccgggag acgcccagac tgtgggccac cttgacgagg
     2461 gtctccacgg tcaggttggt tccgtccgcg gattcggcgg cggccagggt gcgcttcgag
     2521 accccggcga gttccgccag ccgggccagg gtgaaggggc cttcggggtg gtggtggcgg
     2581 atgtgccgga gcctgcgggc gatggcggtc ttggcggcgt gcgcggcccc gtccggaccg
     2641 gcggacgtgc ctgccgccct ggcgagttcg tggcggtcca accttgtccc tccgtggcgt
     2701 gtgcgctagg gggtgtctct tcgatctccg tggatcagcc tgcggcgtct ggtgccgtgc
     2761 atcgcaaggc ggagcatctc ccgcggactg ggtgtccgtg ggtgatgtga caacgcagcg
     2821 tgggggcacc cccagcgtta gctgggggag tgcggtgcca ggcgtcgcag gcccgcggag
     2881 atcggagaga caccccctaa agggtcgcac gcggcacagt gccccccggt gcagggtacg
     2941 cggcaccgtt gacctgcgta cggcgggacg agacgcccgg cctcggctgg ggggaaacgc
     3001 gcccgtcgga atccggtttg gccggaacag agcggcccca tggccgaatc gggcgaccgg
     3061 tcagataccc ggggcctcgt cgtgcacggt gtgcagcccg gggcagatgt gcggggccgg
     3121 caatggccac ggggacgaca gggcggattc caccgccatc gactcccgcg cggtccgttc
     3181 ggcctcgctg cgggcggctc ccaggcggct gcgccagatc agttcctcgg cgatgccata
     3241 ggcccaggag ccgagccagc cgctctgcca cgggcagtgc agcgccagcg caccccgcaa
     3301 ggcgtcgtag gcccgcagga gttggtggga gagttcagcg tcgagatgct cggcgtgcgg
     3361 acgctcgtgc agcggcggga ccgggcagtc ggccagcagg tgggccactc gccgccgcag
     3421 caactccgct ccctcctgga gccgttgggc cgccgacccc ttcgggcacg actcctccca
     3481 gagctcttcg agcggatcgc cgtcccgggg ccacggctgc gcgggcgcct cgtcgcacgg
     3541 ggaagcgtcc gccgcggccg gggaaggctc actgccaccg cagtggtgtg gacactccgg
     3601 gacgtgatcc gccacgggag agtgccggag gaagtgttcg tagcgcagtt gggaccacag
     3661 atcacgcggc gcggccggtc cggtgagcag ccgccagacg gggcccacgt tccaggtgta
     3721 gccggtgacg cgctctatgt gcccggagcc gcgcgtggca aatacggcca gccgcccggt
     3781 ggaattgtcc tgcacctgcg tgtagaggct ttccccgagt tgccaggcgg cgcctatgcc
     3841 gaacggcgct tcctgagcgc ccgttgcccc tttgtgcgcg gcgaccggta cgagcgtgtg
     3901 caatgccgtg ttctgcgccg gttttccctg ggcgacgagg aagggaattc gctctcggcg
     3961 actgccggag aggtaactgc tgcgatcagc cgccatgcgg gtcccccgtc gtggttcggc
     4021 atgcgacaac agccgtatcc ggcttggccg cagaagctat gacggtcact ggtcgtcccc
     4081 ctatggccat ctttcgacgg ccccgcttcg agacgataga cataagcgca ctgctggtgc
     4141 aactaactgc tgatgtcatg caataaattg cacctcgacc atggctgggg cgccgaaagc
     4201 gggaggcacg acgggcccgc agtatgccgt ggccggcgcg gctatgccgg ttcgggtgcc
     4261 ggcctgccgg tacgggcccg tcggcgcacc cggtcgagca gacctgcggg gtccggttcg
     4321 gcctggaggc cgcggagcag cagcagccac aggtcgtgca gatgggcctc gatgtgccgg
     4381 cgcccctcca gggcgtcgga gacggtgtgc agtccgaaga aggcgcagac gacgctgtgc
     4441 gcggtggcgg cgggcggcac accggcggcg agttcgccgt tgtcgccggc ttcttcgagg
     4501 agttgggtga ccgcgtcgat ccagtcgagg aacggggcgg gaagctcggt ttcgatggcc
     4561 ttgcgttcgg cccagagacg ggatccggcg cgtaccacga tgtcgtcacg gaacgcccgg
     4621 gccacgtcga agctcagccc gacgagtctt tccagagcgg gcagaccggg cttccggtac
     4681 cgggtgatca attgcggcca ggtggcgaaa tgctcctcga caatggcgag ggcgagcttc
     4741 tccttgctgg cgaaatggaa atagatcgcc ccgctggtgc ggccggaatg tgcgctgata
     4801 tcgctgatgc tggtgccggc gtaccctcgc tcgtcgaaca gggccgccgc cgcctccaga
     4861 aggaacctgc gtgtcgtctt cgcccggatc tgcacgtaca cctcagatgt cgttctcgtg
     4921 ccggcggccc gcaatctatc gcgctgcgcc acccggaatg aacaggtgcg catgttcgaa
     4981 tttcgatatt ccctggtcgt atgagtacct caactgctgg caccgccgga aagagtgagc
     5041 cgctcagctg gtcccgcacc gtcgagcggg agctggtgca ccggacttcc gtggcggagg
     5101 tcctccttac ggatgtacgg cggacggata ccccccatgt cttcgccgcg gccgcgtcgt
     5161 ggccgcgcgc ccatgcgacg ttcccccgcg acggagcacc gcggcacagc ccgttgatcc
     5221 tcgtggagac gctgcgtcag ctcggtctct acatcccgct gcggttctac gccgttcccg
     5281 cggcgtgcca cgcggtcatc accgacctgt acttccgcct cgcgcccggc aaggagccac
     5341 cggcccgcgc cggagcgacc gaggtcacct gccgcgcgcg ggtgagcgcg gtacggcgcg
     5401 atccggaccg tcgcgtcacc ggcctgcgcc tggacgccgc cttcaccgtc tgcgggctgg
     5461 ccttcggaca gggaggcggc ggtgtgcggt tcctcagcga cgcgcagtac ggcgccctgc
     5521 gcggcaggtc cgcccgcgtc ggcatggtga cccccgcccc ggaagcggcc taccgcccgc
     5581 cggcggcgga actgtcggtg aaccacccgc aggacgcggt ccttgccgtc gccgggggcc
     5641 ggctgctcct ctcgccggcc gacccgctgc acccgttcct cttcgaccac ccgaccgacc
     5701 atgtgccggg catggccctc ctggaggccg cgcggcaggc cgcctcgtac ggcagcaggg
     5761 gcgccctggg ccggccgcgc gccgggcgca tgaaggccgt gcgcttcacc gaactcgccc
     5821 cgcccgcacg ggtgctgtgc acgcagtacg actcgacctg cgtcttccgt gtcacccagg
     5881 gcgacacacg gacggcctac ggaaccctga gttactcata gaaacataaa atatggacaa
     5941 ttaggagtct attgaccacg ccgagttgcc gtccgtaacg taacgatcgt tattttccgc
     6001 tgcagagcgc accaggttcc cccttctcgg tggctgccct ctgccggaaa cccccgcccg
     6061 gtgcccggcg gccgtcatcc gacgctgcct cgccccgcac gcgaccggtc attcgccgct
     6121 ccgggcctgt cggaacggaa acccggatga ccgcacatcg ctttttctcc tggacacccg
     6181 ccgccgtggt cttcgactgc gacggcaccc tgatggacac cgaacgccac tggcaggatg
     6241 cccgcgacat ggtgctgcgc gaatacggct gcaccccctc ggccgaattc tccgaacagg
     6301 cccggggtct gcactacacc gagtgcgggc gcctgatggc cgaggcggcc gaccgccccg
     6361 acctgaccaa ggacatgacg gacaccctgc tcgaccgctt ccgcgacctc gtggcggcca
     6421 accccaccac catgcccggc gcgccggaac tggtgcattc ggccgtgcag ttcgccccgc
     6481 tggcggtggc cagcaactgc ccgctggaag tcgtcgagtc gtgcctggac atggccggac
     6541 tccgggactg cttccgccac atcgtggtgc ccgacgccgc catcaggccc aaaccgcacc
     6601 ccgacgtgta cgtcaccgcc gcccggctct gcggagtcga tccgggggac gccctggccg
     6661 tcgaggactc ccactgcggc gtgcaggccg ccgcggccgc cggcatgcgg gtgctcggcg
     6721 tcggcgcaca acccggcgag aaggaacagg cgctggccga ctggtgggtc gactcgctgg
     6781 aggagccgac ggtacaaggg tgggcggacg cctgtatccc ggcccaggac accgggcccg
     6841 gcggcctcag ggccaccggc tcctaggccg gttcagggcc gtcccgtccg gtctgcggtc
     6901 aggtcgcctg tcccgtccga cctgcggtca gggctcccgt cgcactcggc ctgcggtcag
     6961 gactccggtc ccggccgctg tccgtccgtg gcgcgcatga ggccttcggt gccggtcata
     7021 taggcctcga cggcccggcg ggcggcggcc tcgtcgcccg cggccaccgc ctccgccacc
     7081 gggtggaggc ggtccgcggc ggcagcggcg tcctggaacg gccgggcgag cgcctggcgg
     7141 accgggaggt agccgccgag cagggtgttc gtcatgagca gatagacgcg gttgccggtg
     7201 gcgcgggcca gggtgcggtg gaactcggcg tcggcgagct gcacctggtc ggcgtcgccg
     7261 ccggcgcgca ccgcggcgac ctgctgccgc agcgccgcga cgtcccgcgc ggtcgcccgg
     7321 cgggccgcca actcgccgat cagcacgccc acttggcgtc gtacctcgaa gatctccgcc
     7381 agccaggcgc cgtcccgcag caccagggac ggcaacagct ccgcggtccc cagccgccag
     7441 aagtcccgga cccgcgtgcc cactccgtgc cgggtctcga ccaggcccgc ctgcatcaga
     7501 cggacgaacg catgcttgag cgtggtgcgg ttgaccccgt aggaggcggc cagctcgcgc
     7561 tcgggcggca gcagcgcacc caccgggtgc cggccgtcga tgatcgcgtc ccgcagccgg
     7621 cgctccaggg cgtcgaccgt cgtgtcacga gtgatcggat cgtccatcgg tgccgccacc
     7681 gttcccccca ccccgcgccg cccgggcggc cgtcctccgt tgccgtgcgc gccccaccgt
     7741 acaagggcgc cgggccggcc cgtgaggtgg tcacgcctgc cgtacgtccg gccgtacgcc
     7801 gaggtgtccg gccgggcctg gggccgcgcc gcgcggccgg accggggctc agccgccggc
     7861 cgcccggcag gccgcctcgg acacggcgag ggccaacgcc atgatcgtga gctgcgggtt
     7921 gacctccggg cagctgggca gcgcggagcc gtccgcgaac accacgcccc gcacaccgcg
     7981 cagcctgccg agcggatccg cgggtgcccg ccgggcgtcg gcccccaggg cgacggtccc
     8041 ggtcgggtgg aaggccgaca ggtggagttg ccgcggggtg accggttcga ggacggcgtc
     8101 cagctcgcgg gtggtgcgga cggacggggc gcccggtacc cccgtgaaca cctcctcggc
     8161 gccggccgcc agcagcagtt gacccatggc ccgtacggcg cgcagcagcc gccggccgtc
     8221 gcgcggggcg aggcggtacc aggagaccgc ccgctcccgg cccgtcaccc ggccgccggg
     8281 ccggtcggcg atcatggcgc cgagggtggc gaggtggccg gagcggtcga ggccggcgcg
     8341 cagcgcccgg cccgcaccgg gcagcacgaa cgagctcagg cccggcggtg gagcggtggc
     8401 ctccaacagg attccctggt cgtggagttc ctccacgccg gcgctctgca gcaccgacgg
     8461 tgtgccggcg accggctcgg cgaagcggcc cgccacgctg gtcgcggggt ggaccgcgag
     8521 attgcggccg gtcatcggat ggctgccaag gccggaccgg cgcagcagca gcggtgactg
     8581 gagggcaccg gcggccacga ccaccagcgg ggcgaggttc tcgaaggtgg tgccgtccgg
     8641 ccgccgggcc gcgaccccgg ccacccgggg gccgcccggg cggtcccgct cgaccaggag
     8701 gcgccccacg cgggccgagg tgacgatgcg ggcgccgtgc gcgcaggcgt cgggcagcac
     8761 cgacagctgc acgctctgct tggcccccgt cgggcacccc acgacgcact cacacgagcc
     8821 ccggcagccg ggcgcgttgc ggcgcagggc gtcggcccgc cagcccagcc gctcggcgcc
     8881 gagcagggcg agacggccgt tggtccccag gacatcggtc ggctgccggg ccacggacag
     8941 ggtgcgttcg gcctcgtcca gctggcggcc gaactccggg gcgtcggcga gcggcaggcc
     9001 gaagtcctgc cgccagcggg ccagcacccg gtccggagtg cggtagcagg taccggagtt
     9061 gacgagcgtg gtgccgccca ccgcccgtcc ggtcggcagc agcacgccgg gcacgcccag
     9121 catgacgctc gcgccgccgt cccggtagag ctcgccgaac cggtcgagcg gggtacggcg
     9181 ggcgaactcg gcggtgctgt ggtggcggcc ctcttccagc accagcaccc gcagtccggc
     9241 ccgggccagg gtgcgggccg cgacggcgcc gccggcaccc gagccgacaa cgacggcgtc
     9301 cgcggtctgc cggtccggcc actgcgccga gggcacacag tccagcggcg ggtccgcggg
     9361 cgctgccgaa cgggccgccg gggtggtgcg gcgcgcgtgg aattccgtac cggccgcgag
     9421 gagcaccgga atcttgacca ggtccaggag gtgcgccgtg cccggcccgt tcaccaggcc
     9481 ggtgacggtg cgctcccgct cgtccggggt gaggcgggcg agcggccggc cgtgacgggc
     9541 ccgggcagcg gcgtcgacgg cggtcgccgc cgcggccatc gccgcacggg tggcgcgcgg
     9601 catggcggcg agggcggcat cgagacggcc ggccaccgcg cgcaccgtcg ccgggtcgtc
     9661 ctcggccagc agcgcggcca gcagcccctc ggtcgcggtg ttcatcgctc ccccacctcc
     9721 gcgtgcgcgg tgccgcgcag ggtccatgcg gcctccgggc gccagccacc ccaccaccgc
     9781 tccaggacga catgggcgtc ggccgtgacg ctgttacggc acaccgcacg gctgccgtcc
     9841 gggtcgatgt actccagcgc cagggtgcgt gcttcgggct ggtgcaccat gacccggatc
     9901 cggcgcggtc cggcccgtcc ggtgacggtc caggagggca ggcccacgtc cgcgcggaag
     9961 cggcccagcc cgaaccagcc ggccgcggtg cgggtgccgc gccggggcca gtcgcggccc
    10021 gcccggcgca gccgcaggaa caccagcggg ggcagccggt ccagccccgg gcggcgggcc
    10081 accgccgcca ccacctccag gacgtcaccg ccgccgaggt cggcgtgcag ccaggcccag
    10141 cgccgggcgt tgccgtggcc gtagatccgt ccggtggcgc cgggggcacc ggccagggtg
    10201 aggtcggtgc cggggccgcg gaccgtcccg gtgtagcggg cccggccgcc cggcacgatc
    10261 tgcgcggccg gcagcagggg gcggcgccag gcccaagcgg ggaacgtgtg cagcgtgggg
    10321 ccttcttgat cctccgtcag gtcccaggta tagggcccgc agctgccgtg cagccggccg
    10381 ggtccggccg cgacgccggt ggtccggaac ccggtggcat cgggcgtgac cggttcggga
    10441 ccgaagcggg cgtgggcgac cggcccgccg ggcgggcaca cggccaccca gccgtgcgcg
    10501 tagccgccgc tcccgtcctc gggggccgtc acctcgtggt gcagccagag accggtgccg
    10561 gtcgacggct cggtgacggt ggtgtaccag acctccgtcc ggccgggccg gccgttccac
    10621 cgtggggcga gctgctccgg gccggggtcc acggccggga agcggaagct ggcgaggaac
    10681 ggcagcaggg cgccggcgag cgagaagcgc agcgtgccgc gcccggcctc ctgctgagcg
    10741 tcgtcgtgga cggtgaaggg caggacggtc agggagtgca gcgggcggcg cggcgagagg
    10801 gacttccagc cgtccagcag gcaggtgcgc ccggccgtgc ggaaggagag gcggtagcgg
    10861 atgcggcgcc gggcgagcgg cgagatctcc atctcgcccg ccacggaggc ctcctcgccc
    10921 c
//
