LOCUS       NZ_LT907981            10468 bp    DNA     circular CON 12-FEB-2024
DEFINITION  Streptomyces sp. 2323.1 chromosome I.
ACCESSION   NZ_LT907981
VERSION     NZ_LT907981.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. 2323.1
  ORGANISM  Streptomyces sp. 2323.1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 03:31:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,058
            CDSs (total)                      :: 6,971
            Genes (coding)                    :: 6,808
            CDSs (with protein)               :: 6,808
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 163
            CDSs (without protein)            :: 163
            Pseudo Genes (ambiguous residues) :: 0 of 163
            Pseudo Genes (frameshifted)       :: 64 of 163
            Pseudo Genes (incomplete)         :: 123 of 163
            Pseudo Genes (internal stop)      :: 17 of 163
            Pseudo Genes (multiple problems)  :: 37 of 163
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 216024
            Orig. end                         :: 226492
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT907981.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10468
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="1"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10468
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10468
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5468](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5468)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            1348..1736
                     /locus_tag="CPH93_RS00930"
                     /old_locus_tag="SAMN06272775_0198"
                     /pseudo=""
     CDS             1348..1736
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328281.1"
                     /locus_tag="CPH93_RS00930"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0198"
                     /product="VOC family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MADAPMRINALIVDATDPERLAAFWSELLGRPVVGRTGPYVWLRR
                     ENDLGLGFQQTAEPKSGKNRMHFDITSPDPAAEQQRVEALGGRRLEQYADGGSW"
     gene            complement(1760..1960)
                     /locus_tag="CPH93_RS00935"
                     /old_locus_tag="SAMN06272775_0200"
     CDS             complement(1760..1960)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133221.1"
                     /locus_tag="CPH93_RS00935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0200"
                     /product="type II toxin-antitoxin system VapB family
                     antitoxin"
                     /protein_id="WP_093488170.1"
                     /transl_table=11
                     /translation="MAKVNISLDAELVVEVMVLAGVGSPQDAVELVVRDYIARGHRTEA
                     RTELKDQGLREAAVKPPEPQG"
     misc_feature    complement(1934..1948)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            2197..3882
                     /locus_tag="CPH93_RS00940"
                     /old_locus_tag="SAMN06272775_0201"
     CDS             2197..3882
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024965.4"
                     /locus_tag="CPH93_RS00940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0201"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_096211617.1"
                     /transl_table=11
                     /translation="METTSPEWDHCGAGATDADPVGCRGVRAGGRARCLAHLAADARAV
                     YLAQLAAGADVDCRGVTFDDGLLAAVLAGLTGEDVFPVFGSGLFEQARFAESASFAGAE
                     FRGPASFQGTRFEGAADFGSVRFRHGAWFKGARFAGPADFGGAHISDDAGFADTWFGGT
                     AWFGGVRIEGRLWLERARFAEDAVFLRGVFGADWVGPLTCDGALSLAEAEFRSPLRLAL
                     AASRVDARAARCEGPVTLSVRYAAIDLTGAVLLHPCRISTDLVTELRQPAAARADGADH
                     TASIVSLRGVDAAMLTVADVDLRGCHFAGTHHLDQLGFEGNWQLGASPRGVRWHRGVPR
                     SWTRRLVLEEERQWRALPGRGATARRGWGAAPDNPDTVPGLATLTSTYRQLRKAREDAL
                     DQPGAADFYYGEMEMRRHSHTWRRAERWLLQAYWLLAGYGLRASRALGWLACAVAGTVV
                     LMMGLGLPDTEPQQQVRRVQGGGSLRMVMDKAEPQLTLPVGERFTGERFEKSLRVVLNS
                     VLFRSSGQDLTLWGTYTEMVSRLTEPVLLGLAALAVRGRVKRGS"
     gene            complement(4142..4960)
                     /locus_tag="CPH93_RS00945"
                     /old_locus_tag="SAMN06272775_0202"
     CDS             complement(4142..4960)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608160.1"
                     /locus_tag="CPH93_RS00945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0202"
                     /product="tyrosinase family protein"
                     /protein_id="WP_093488166.1"
                     /transl_table=11
                     /translation="MAVRKNQADLTATEKRNFVDAVLELKRSGRYDEFISTHNAFIIGD
                     SDDGERTGHRSPSFLPWHRRFLLQFEQALQSITPSVMLPYWDWTADRTPRSSLWADDFL
                     GGDGRSGDGRVTSGPFAFGSGKWPMNIRVDGRTFLRRSLGTGVRELPTRAEVDRVLAMS
                     VYDAAPWNSSSDGFRNNIEGWRGPNLHNRVHVWVGGQMTTGASPNDPVFWLHHCFIDKL
                     WADWQGMHPKSGYLPTGDTPDVVDLHDTMKPWNDVTPADMLDHTKFYTYQ"
     gene            complement(5001..5468)
                     /locus_tag="CPH93_RS00950"
                     /old_locus_tag="SAMN06272775_0203"
     CDS             complement(5001..5468)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608161.1"
                     /locus_tag="CPH93_RS00950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0203"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_096215235.1"
                     /sec_met_domain="melC (E-value: 7.3e-38, bitscore: 128.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRPTRRQILHGSAAALAGAALAAPVAFADTAAARPADGHGQMAG
                     DGPSGGHEMPEPFDEMYEGRHIEGWPADEGDAQNGGHNSSGAHAGRHAGPHDGMDFVVR
                     IDNDDLHVMRNADGTWISLVNHYETFTTPRALARAAVRELQGADLVPVVTG"
     misc_feature    complement(5681..5698)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.64"
                     /tool="antismash"
     gene            complement(<5970..6248)
                     /locus_tag="CPH93_RS37405"
                     /old_locus_tag="SAMN06272775_0204"
                     /pseudo=""
     CDS             complement(<5970..6248)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF044908.1"
                     /locus_tag="CPH93_RS37405"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0204"
                     /product="thioesterase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEWRFEPGKGFDTPGACMAWARQRIQLVAGEEDTPLTRALARADS
                     SWAAAFALDDQQRLVINTDVTLALNREPVGEWFCVRSATAASPRGSGL"
     gene            complement(6512..7279)
                     /locus_tag="CPH93_RS00960"
                     /old_locus_tag="SAMN06272775_0205"
     CDS             complement(6512..7279)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016578149.1"
                     /locus_tag="CPH93_RS00960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0205"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_096211618.1"
                     /transl_table=11
                     /translation="MDQDTVLAVFDREVRQGIRADGPGARVERVGGVVRHVGADADGWN
                     GIVWSDLDEATADGSVAEQVEYFTSLGRGFEWKLYGHDRPADLPGRLRAAGFVPEPEET
                     LMVADIKDLSTSVELPEGVRLLPVTDAAGVELAVAAQERAFGEARPYHRQLLLGQLAAG
                     LPPAVVAMAGDVPVSAARMELHPGTSFASLWGGGTVPEWRGRGVYRALVAFRTRVAAEH
                     GYRYLQVDASDQSRPILRRLGFVPLATTTPYVR"
     misc_feature    complement(6788..6790)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(<7506..7997)
                     /locus_tag="CPH93_RS00965"
                     /old_locus_tag="SAMN06272775_0206"
                     /pseudo=""
     CDS             complement(<7506..7997)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981454.1"
                     /locus_tag="CPH93_RS00965"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0206"
                     /product="IS5 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRGDLSDQEWARLEPHLPKDGGRGGRWKSHRRVINGILFRQRTG
                     VPWRDRPARFGKWKTVHDRHRRWSADGTWERILLTVQAHADAEGQIDWSMVSVDSTTCR
                     VHQHAAGARTDAPRTPGRRGRPVRHRSDEALGRSRGGLTCKIHLAGEGGRRLLAFVITP
                     G"
     gene            complement(8051..8413)
                     /locus_tag="CPH93_RS00970"
                     /old_locus_tag="SAMN06272775_0207"
     CDS             complement(8051..8413)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CPH93_RS00970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN06272775_0207"
                     /product="hypothetical protein"
                     /protein_id="WP_096211619.1"
                     /transl_table=11
                     /translation="MPARISLTCGTSVNPNTLSRPETITSTRIGRATVSLRDGHRGGRI
                     YLWARITGARRGDTVRLDWTDFGLGGRRHQCSATVHTGSDQHTVAAQYLQSGSDHREFR
                     ACGHHDGATRCTRWMP"
     misc_feature    8568..8583
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.66"
                     /tool="antismash"
     gene            8823..9479
                     /locus_tag="CPH93_RS00975"
                     /old_locus_tag="SAMN06272775_0208"
     CDS             8823..9479
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992216.1"
                     /locus_tag="CPH93_RS00975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0208"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_093488158.1"
                     /transl_table=11
                     /translation="MDLPQQVIELDGLTLRRFNGEADLPEFFRVIEESLEHLRPWMPWV
                     AEHSLARTTDFLAQRPERWASGEEFTYAIVLDGAIVGACGLFRRDDVPDNGREIGYWLH
                     PGATGRGVATRTARALVEQAFRLPGVDFVEVVHDPANRASGAVPARLGFTEHLRRPAER
                     LAPAETGEDQIWRLTRGQLEASSPRPAPHPDATIASPRSENQVANWGRQRRTCRA"
     gene            9467..10033
                     /locus_tag="CPH93_RS00980"
                     /old_locus_tag="SAMN06272775_0209"
     CDS             9467..10033
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992349.1"
                     /locus_tag="CPH93_RS00980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN06272775_0209"
                     /product="DinB family protein"
                     /protein_id="WP_096211620.1"
                     /transl_table=11
                     /translation="MPRMSEQPARWTKATVYPDMWTDPDDDPRDQGVSPDGELATLQDF
                     LTGYRMTLRMKCEGLDAEQLARRSVPPSTMSLLGLVRHLVEVERDWRNWISDGDPLPKL
                     YGKRDADFDGAVAEQAVVDAAYVDLEREQAATDAALAEHPDLGERVGKEGIAVRELMVH
                     RIDEYARHCGHADLLRECIDGRVGQ"
ORIGIN
        1 ccaggatccg gacgcgttct tgacggcgcg ggtgggcggg cgcagcgcgg tcatcagttc
       61 caggccgcat acggcggtcg agccgagcgg tgtgatgacg cgctgggcgt aggagccgag
      121 gaccgcggcg acgtcggccg gcggcagctg ccccgtggca ccccaggaac gctcatcgag
      181 cgcgccccac ggcaggacgg ccagctgcac gcactggcgt ctgccgccct ccgtgggccg
      241 gtagatgcgt gcccagggac cgaagccgcg ccgggtcagc ttccactcgg cacgcgccag
      301 ctgcttgagc acctggtggt cctcgggcag gcgcagaccg cgacggtcct ccagttcggc
      361 cggcagaccg aggcgtccgg cggccgcagc ggtcagcacg atcagcgggt cggcgtcctt
      421 gccggaccgg tgcaggcgcg gcgcaccgag cttcgcctcg gacagcgtcc attcgaccag
      481 cgccgggagg gtcttggccg ggcagtcgag caccagcccg ccgacgcaat acagcgaacc
      541 gtcttcgtcc agcacgccca gcggtccgtg ggcgaagcgt gggtcggtgt cggtcggagc
      601 ctcggccggc tttttgggtg gggtgttttt cggcggggcg tatttcggcg gggtcttctt
      661 cgggaggccg tttttcggcg gggcgttcct cgcggccggt cgctgtgacg ggggcggcgg
      721 ctcggtgtgg acggcctggc ggggcgcagc gtcggcggca gccggggcca gtgctggtgc
      781 ctgtgccgat gcctgttctg gagcagccgg ggccgggatg gcgggttcgg gggcgacggg
      841 ctgcggtgcg gtcggcgcgg aggcctccgg caccgtcggc gcggggcagt cggccgtggt
      901 ggcgacgtcg gggtatcggg cggcaaggcc ttccaagagc cgggcatatg cggctcgttt
      961 gggcggccgc ggctcggtcc tgcccacctc ccagctcgtc accgtctccc gccgtaccga
     1021 cagggcacgc gccacctgat cctggctcag gccgcccgcc tcacgcagcc gccggcgttc
     1081 cgccggatcc ggcagcgcgt cctggtccgc cacgtgctcc agcagcgcgt cgaccgatgc
     1141 gaacagcttg tcctgctcgt tgggcacagg atcacctcca ggccccactc tagttgaaac
     1201 acacctgccg tcgcgctgaa gcgcacggcc gacaccaggc agaatgccgt cccgccacgg
     1261 cagccaccga ccggttggct cttccgccgc gcacggcgca ggtggcggcg ccgtgcgcgg
     1321 ccttgcccga cctgagagga tcaaggcatg gcggacgcac ctatgcggat caatgccctc
     1381 atcgtcgatg ccaccgaccc cgagcggctt gccgcgttct ggtccgagct gctcggcagg
     1441 ccggtcgtgg ggcgcacggg accgtacgta tggctgcggc gtgagaacga cctgggcttg
     1501 ggcttccagc agaccgccga acccaagtcg ggcaagaatc gtatgcactt cgacatcact
     1561 tcacccgacc cggccgccga gcagcagagg gtcgaggcgc tcggcgggcg caggctggag
     1621 cagtacgccg acgggggttc ctggtgatgg ccgaccccga gggcaatgag ttctgcatca
     1681 tccccgaggg ctctttcgag ctcgacgacg agggacgcgc gcactacctc agctgaccga
     1741 cgtctcgacc gccgaggggt cagccctgcg gctccggcgg tttgacggcg gcctcgcgca
     1801 gcccctggtc cttgagttcg gtacgcgcct ccgtgcggtg gccgcgggca atgtagtcgc
     1861 gtacgaccag ttcgacggcg tcctggggcg atcccactcc ggccaggacc atcacctcca
     1921 ctaccagctc ggcatcgaga ctgatgttga ccttggccac ggctctcccc ttcgtcgcgt
     1981 cgctcccaga gtctcaccac tcaaggtgcc gtggcatcca ctcgggttcg atgccaggac
     2041 tcgatacggt cctcgaccga gagcggcggg agacgggcgg ccagcaacgg gcagccggcg
     2101 ggtcgcgtca tgtagcggga gcacggacct tcttgagcgc gcgcaggacg cggaaagtgg
     2161 ctgcgcacag cgcgcggtgc ctgttgagat caagccatgg agacgacttc accggaatgg
     2221 gaccactgtg gcgccggcgc aacggacgcc gacccggtgg ggtgccgggg cgtccgagcc
     2281 ggcgggcggg ccaggtgcct ggcgcacttg gcggcggatg cccgtgcggt gtatctcgcg
     2341 cagctggctg ccggggcaga cgtggactgc cggggagtca ccttcgacga cggcctgctg
     2401 gcggcggtgc tcgccggcct caccggtgag gacgtgtttc cggtgttcgg ttccgggctc
     2461 ttcgagcagg cgcgattcgc ggagagtgcg tccttcgccg gtgcggagtt ccggggcccg
     2521 gcctcttttc aagggaccag gttcgagggc gcggcggact tcggcagcgt tcgcttccgg
     2581 cacggcgcgt ggttcaaggg ggcgcgcttt gccggacctg ccgatttcgg cggggcccac
     2641 atcagcgacg acgcgggctt cgccgatacc tggttcggcg ggacggcgtg gttcggcggg
     2701 gtacggatcg agggcagact gtggctggag cgggcgcggt tcgccgagga tgccgtattt
     2761 ctccgtggcg tgttcggggc ggactgggtg ggtcctctga cgtgtgacgg ggcactgtcg
     2821 ttggccgagg cggaattcag gagccccttg cggttggcgt tggcggcgtc ccgggtcgat
     2881 gcgcgagcgg cgcggtgcga gggacccgtg accctcagtg tccgttacgc cgcgattgat
     2941 ctgaccggtg ccgtgctcct gcacccctgc cggatctcca cggacctggt caccgagctg
     3001 cggcagccgg cggcggcgcg cgcggacggc gcggatcaca cggcgtcgat cgtctccctg
     3061 cgcggcgtgg acgcggcgat gctcaccgtc gccgatgtcg acctccgcgg ctgccatttc
     3121 gccggtaccc accacctcga ccagctcggg ttcgaaggaa actggcagct cggcgcatct
     3181 ccgcggggcg tccggtggca ccgaggcgtg ccacgctcct ggacacgacg gctggtcctc
     3241 gaagaggaac ggcagtggcg tgcgctgccg ggccggggcg caacggcccg ccggggctgg
     3301 ggagcagccc ccgacaaccc cgatacggtc ccgggactgg ccaccctgac ctccacctac
     3361 cggcagctcc gcaaggcccg cgaagacgcc ctggaccagc ccggggccgc cgacttctac
     3421 tacggcgaaa tggagatgcg ccgccacagc cacacctggc ggcgcgccga gcgatggctc
     3481 ctccaggcgt actggctcct ggccggctac gggctgcgtg cgtcccgcgc actggggtgg
     3541 ctcgcctgtg cggtggccgg cacggtggtt ttgatgatgg gactcgggct ccccgacacc
     3601 gagccgcagc agcaggtcag acgggtgcag ggcggcggtt ccctacggat ggtcatggac
     3661 aaggccgaac ctcaactcac ccttcccgtg ggcgagcggt tcaccgggga gcggttcgag
     3721 aagtccctgc gggtcgttct gaactccgtc ctgttccggt cctcggggca ggatctcacc
     3781 ctctggggca cgtataccga gatggtctcc cggctcaccg aaccggtgct gctgggactt
     3841 gccgcacttg ccgtccgcgg acgcgtcaaa cgcggaagct gagggcccgt ccgggcctcc
     3901 ccttactgtc cgggcctccc ccgccggcac ggccacgcac cgcggcgagt ggccgtgccc
     3961 gcagagtcgg aagggtccgt agggcccgca gagcccgaag agccgtaggg cccgcacccc
     4021 gtgcgcaccg gcgcagtcgg ggcgaccttc ggcggcgaag gaggcgggct ccgcggtcag
     4081 gatccggccc ggacggagcc gcgatcaggc accttttacg gaccgaaatg tcatggacct
     4141 gtcactgata agtatagaac ttggtgtggt ccagcatgtc cgccggcgtg acgtcgttcc
     4201 atggcttcat cgtgtcgtgg aggtcgacga cgtcgggtgt gtcgccggtg ggcagatagc
     4261 ccgacttcgg gtgcatcccc tgccagtcgg cccagagctt gtcgatgaag cagtggtgca
     4321 gccagaagac cgggtcgttg ggtgacgctc cggtggtcat ctggccaccg acccagacgt
     4381 gcacccggtt gtgcagattc gggccgcgcc agccctcgat gttgttacgg aaaccgtcgg
     4441 aggagctgtt ccagggagcg gcgtcgtaga cgctcatggc aagcacccgg tcgacctcgg
     4501 cgcgcgtcgg cagttcgcgg acgccagtgc cgagcgagcg gcgcaagaac gtccggccgt
     4561 ccacccgtat gttcatcggc cacttgccgc tgccaaaggc gaacggcccg gaggtcaccc
     4621 ggccgtcgcc gctccgcccg tcgccgccca ggaagtcgtc ggcccacagg gagctgcggg
     4681 gcgtgcggtc ggcggtccag tcccagtagg gaagcatgac cgacggcgtg atgctctgca
     4741 gggcttgttc gaactgcagc aggaacctgc ggtgccaggg aaggaaggac ggtgaccggt
     4801 ggccggtgcg ctctccgtcg tcgctgtcac cgatgatgaa ggcgttgtgg gtgctgatga
     4861 actcgtcgta gcggccgctg cgcttgagct ccagcaccgc gtcgacgaag ttccgctttt
     4921 cggtggcggt gaggtccgcc tggttcttcc ggactgccat gtcgaggact cctcggtggg
     4981 gggacggtca ggggcaggcc tcagccggtg acgacgggga ccaggtcagc gccctggagt
     5041 tcacggacgg cggcgcgcgc cagggcgcgt ggcgtggtga acgtctcgta gtggttcacc
     5101 aggctgatcc aggtgccatc ggcgttccgc atcacatgga ggtcgtcgtt gtcgatgcgg
     5161 acgacgaagt ccatgccgtc gtgcgggccg gcgtggcgcc ccgcgtgggc tccgctgctg
     5221 ttgtgacctc cgttctgggc atctccttcg tctgccggcc agccctctat gtggcggccc
     5281 tcatacatct cgtcgaaggg ctccggcatc tcgtggccac cggagggccc gtctcccgcc
     5341 atctgcccgt ggccgtcggc ggggcgggcg gcagcggtgt cggcgaaggc gaccggtgcg
     5401 gcgagcgccg ctccggccag ggccgcggcg ctgccgtgca gtatctggcg ccgggtggga
     5461 cgcgacatgt tccactcctt ggttcgtctc ggctcccctc cggggccggg ccgcagaggg
     5521 ttgttgagcc ggcgcgccga cggtcggccc gcgccgccac atgctggcag ggacgaacgg
     5581 atcatcaagt tgcaccggcg aatcaagcag cgaacgagac aacacctggg cggaggtgca
     5641 gaattcaacg gcggtgatcg tactgatggg ccgtcagacc tctccgcgga accggatatt
     5701 ccgcgatgtg gggcgccctc ggccgcagat ccttctcccg cgcggtcgaa accgtgagac
     5761 cccgcacggg cggaactcgg cgcgaatgca gggggcttcg ggcctacggg gtttgagaag
     5821 cggtccggca gcgacgaggc caccaccgaa ccgagcaacg tgatgcccct gctggccgac
     5881 tgcggcaccg acggcggcgc gctgcccctc cttggtgagg gcgatctgct ggtcgtgccg
     5941 ccggggagca cgtcgagctg cccgagcgcc aggccggatc cgcgggggct ggccgcggtc
     6001 gcagagcgta cgcagaacca ttcacctaca ggctctcggt tcaacgccag cgtgacgtca
     6061 gtgttgatga cgagccgctg ctgatcgtcg agtgcgaagg ccgccgccca gctgctgtcg
     6121 gcccgggcga gagcacgcgt cagaggagtg tcttcctcgc cggctaccag ctggatgcgc
     6181 tgccgcgccc aagccatgca cgcgccgggc gtgtcaaacc cctttcctgg ctcgaaccgc
     6241 cactccattg ctgagcatgc agggtcaggg gcgtccgtac ggcgggcacc cctgactcaa
     6301 ctgcaacgcc accgccgcag cccacaccat ctggctccgc acgtgatcga ccgaacaagc
     6361 cctacggcgt gtccgacggg tcctatcagg ccgcgccggg caggcccatg ggctgctttc
     6421 ccggcggtgc tgaccagtct cgcggtcacc ggcggcctcg tcttcctcgc ggcgctgagc
     6481 ccggtcggtc gatgccgcgt tctgggtgag gtcagcgtac gtacggggtg gtggtggcca
     6541 gcggcacgaa cccgaggcgt cgcaggatcg gacggctctg gtcggacgcg tcgacctgga
     6601 ggtagcggta gccgtgttcg gctgcgacgc gggtgcggaa ggcgaccaag gcccggtaga
     6661 cgccccggcc gcgccactct ggcactgtgc ccccgcccca caggctcgcg aaggacgtac
     6721 ccgggtgcag ctccatccgt gcggcgctca ccggcacgtc accggccatg gcgacgaccg
     6781 cgggaggtaa gccagcggcc aactggccga gcaacagctg ccggtggtac ggccgcgctt
     6841 cgccgaacgc ccgctcctgc gcggccaccg cgagctcgac cccggcagca tcggtcaccg
     6901 ggagcaggcg aacaccctcg ggtagttcga cgctcgtgga caggtctttg atgtcggcga
     6961 ccatcagcgt ctcctcgggc tcgggtacga aacccgccgc ccgcagccgt ccgggtaggt
     7021 cggccggccg gtcgtgcccg tacagcttcc actcgaaccc gcgcccgagt gaggtgaagt
     7081 actccacctg ttccgcgacc gagccgtctg cagtggcttc gtccaggtcc gaccagacga
     7141 ttccgttcca gccgtcagcg tctgcgccga catggcgtac gacgccgccc acccgctcta
     7201 cccgggctcc gggcccatcg gcccggatgc cctgtcgcac ctcgcgatcg aagaccgcca
     7261 gcactgtgtc ctgatccatc cgctcactcc agcatcacca ggcgcaagag gcaacgaaaa
     7321 atgagcggac cgggccggcc cctacccgaa gcgggcccaa gccacggcct cgcggtagcc
     7381 gcccttggcc tgcgcggact tgaggcgacg acggcaagag tgcgcacaac gccgacgcca
     7441 tcaccgctgt aagtccgcta aggctgtcca gcaggtcacg aacgaagcca aagcggaatg
     7501 gggctgcctg gtgtgatgac gaacgcgagc agccgccggc cgccctcacc ggccagatgg
     7561 atcttgcacg tcagcccgcc acgggaacgc cccagggcct catctgaacg atgtcgaaca
     7621 ggtcgaccgc gtcgtccagg ggtgcgcggc gcgtcggtac gggcgccggc ggcgtgctga
     7681 tggacacggc aggtggtcga gtccacgctg accatgctcc agtcgatctg gccttccgca
     7741 tctgcatggg cctgaacagt cagcaggatc ctctcccacg tgccgtccgc cgaccacctg
     7801 cgatgcctgt cgtgcaccgt cttccacttc ccgaaccgtg ccggccgatc acgccacggg
     7861 acaccggtcc gctgccggaa aagaatgccg ttgatcaccc tgcgatgact tttccaacgc
     7921 ccgcctcgtc ccccgtcctt cggcaagtgc ggctccagcc gagcccactc ctgatccgac
     7981 agatcacccc gccccacacc gaccggaacg acgtcagcgc gagcaggtca cacgacccgt
     8041 cgaacagtgc ctagggcatc caccgtgtgc acctcgtggc tccgtcgtgg tgaccgcatg
     8101 cgcggaactc gcggtggtcg ctgccgctct gcaggtactg ggcggccacg gtgtgctggt
     8161 ccgaaccggt gtggacggtg gcggaacact ggtggcggcg gccccccagg ccgaagtctg
     8221 tccagtccag gcgcaccgtg tcaccacggc gtgcgccggt gatgcgcgcc cagaggtaga
     8281 tccggccgcc tcggtgaccg tcgcgtagcg acaccgtggc gcggccgatg cgggtggagg
     8341 tgatcgtttc ggggcgggag agggtgttcg ggttgacgct ggtcccgcag gtgaggctga
     8401 tccttgccgg caccgcagct ccggtcggca cgctgggcgg aggggacgct gcttctaccg
     8461 gggacgggct gagcagcagc agtgtgccga ccgcgactcc catcgtgata cgccggaatg
     8521 tcgtcgtcct gagcaagagc gagcccatcg cgtcctcccg taacttctgg accaactggc
     8581 cgacatagaa ggctatttga gctctgcggg aagctctacg gcgcgcgtgt gagcatgagg
     8641 tgcgttcagg ggcgctcttt cgggagcggc ggtccgtcgc ccgtctgcgg gtgcggcgcg
     8701 caggccgttt tccggcgacg cgcgtacggc gcccgcggca agcgccgccg tccccagccc
     8761 gccccggacc acgtttcgaa accccgttgc cgacagaagc ggctgcatac gatcctcctg
     8821 gcatggatct tccacagcag gtgatcgagc tggacggcct tacgctgcgc cgcttcaacg
     8881 gcgaggcgga cctcccggag ttcttccggg tcatcgagga gtcgctggag cacctgcgcc
     8941 cgtggatgcc ctgggtcgct gagcacagcc tggccaggac caccgacttc ctggcccaac
     9001 gcccggagcg ctgggcgagc ggcgaggagt tcacctacgc gatcgtgctg gacggggcga
     9061 tcgtcggcgc ctgcgggctg ttccggcgcg acgacgtccc ggacaacggc cgcgagatcg
     9121 gctactggct gcaccctggc gccaccggcc gtggtgtggc cacccggacc gcccgcgccc
     9181 tggtcgagca ggccttccgc ctccctggcg tcgacttcgt cgaggtcgtc catgacccgg
     9241 ccaaccgcgc cagcggcgct gtcccggccc ggctcggctt caccgaacac cttcgccgcc
     9301 ccgccgagcg cctcgccccg gccgagaccg gtgaggacca gatctggcgg ctgactcgcg
     9361 gtcagctgga ggcctcgtcg ccgagaccgg cacctcatcc tgatgccacc atcgcatcac
     9421 ctcgaagcga aaaccaagta gcgaactggg gccgtcagag gcgaacatgc cgcgcatgag
     9481 tgagcaaccc gcgcgatgga ccaaggcaac cgtctacccc gatatgtgga ccgatccgga
     9541 cgacgacccc cgcgatcaag gagtcagtcc ggacggcgag cttgcgacgc tgcaggactt
     9601 cctgacgggc taccgcatga ccctgcggat gaagtgcgag ggcctggatg cggagcagct
     9661 ggcccgtcgg tcggtgccgc cgtcgacgat gtcgctgctc ggcctggtgc ggcacctcgt
     9721 cgaggtggaa cgggactggc ggaactggat cagcgacggt gacccgctgc cgaagctgta
     9781 cggcaagcgt gacgcggact tcgacggagc tgtcgccgaa caggccgtgg tcgacgcggc
     9841 gtacgtcgat ctggagcgtg agcaggccgc gaccgacgcc gcgctggccg aacacccgga
     9901 cctgggcgag cgggtgggga aggaggggat cgcagtccgg gagctgatgg tgcacaggat
     9961 cgacgagtat gcccgccact gcgggcacgc cgacctgttg cgcgaatgca tcgacggaag
    10021 ggtgggtcag tgacgagggc cggagtttag gccctttacg cccatcaacg aatgaggatg
    10081 ggtgggatct gcctgcgcgg tcaggaccta atccccggcc gcgaagaacg ccgacagccg
    10141 gcggttgact tcctccgagt tcgacatcgg aaggccgtgg tgtgaggcat cctcgatgac
    10201 cgcgcactcg acgtccggca gcagttcctc cgccccggcc cgcacccgct cgatgtcgtg
    10261 caccttgctg tgccgggcca ggagcacgag cgtggggacg gtgagttcgc gcagccggtc
    10321 ggcgggcggg cgacgtgcca tgaccacctt cgcgggcggt gtgcgggccg cgcccagggc
    10381 gtacacctcc tgccagaccg cgtcgagcgg cagaccgccc gcctcccagg cgatgtgggc
    10441 gcgggcgcgg gcggcggtgg ggcggatg
//
