LOCUS       NZ_FZPH01000030        20442 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Asanoa hainanensis strain CGMCC 4.5593, whole genome shotgun
            sequence.
ACCESSION   NZ_FZPH01000030
VERSION     NZ_FZPH01000030.1
KEYWORDS    WGS; RefSeq.
SOURCE      Asanoa hainanensis
  ORGANISM  Asanoa hainanensis
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Asanoa.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900188485.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 02:44:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,204
            CDSs (total)                      :: 8,124
            Genes (coding)                    :: 7,995
            CDSs (with protein)               :: 7,995
            Genes (RNA)                       :: 80
            rRNAs                             :: 2, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 129
            CDSs (without protein)            :: 129
            Pseudo Genes (ambiguous residues) :: 0 of 129
            Pseudo Genes (frameshifted)       :: 20 of 129
            Pseudo Genes (incomplete)         :: 110 of 129
            Pseudo Genes (internal stop)      :: 8 of 129
            Pseudo Genes (multiple problems)  :: 8 of 129
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:45:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 39103
            Orig. end                         :: 59545
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FZPH01000030.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20442
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..20442
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20442
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:16428](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16428
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(2170..2184)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.54"
                     /tool="antismash"
     misc_feature    2331..2346
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.52"
                     /tool="antismash"
     gene            3316..3924
                     /locus_tag="CHC05_RS38830"
                     /old_locus_tag="SAMN05421812_13043"
     CDS             3316..3924
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024701.4"
                     /locus_tag="CHC05_RS38830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13043"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_218824818.1"
                     /transl_table=11
                     /translation="MDPSRVSYHHGGLRAALIAEGLRVARTGGAAALGMRELTRAVGVS
                     PNAAYRHFADRQALVLAVALEAQDLLADAMRARIAPSASPLDRLRAVGLGYIHFARTER
                     GWFELAILTRDDGPPGTNGPFPAPFQLLLDALDGLVASGGLPAARRAHAEWACWSTVHG
                     FADLTTRGPLRRQDPATLDALASYVVDTVIEGLTSGGST"
     gene            3921..4190
                     /locus_tag="CHC05_RS38835"
                     /old_locus_tag="SAMN05421812_13044"
     CDS             3921..4190
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020496.4"
                     /locus_tag="CHC05_RS38835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13044"
                     /product="DUF1905 domain-containing protein"
                     /protein_id="WP_089255663.1"
                     /transl_table=11
                     /translation="MTDQLDATFTAPIRVDGAFPTYIELPGSHELLGTRKPVKVSGTID
                     GHPFESTLMPSGQGPHWLPVRAALKKTVGKEAGAEVTVHLTARR"
     gene            complement(4204..6381)
                     /locus_tag="CHC05_RS38840"
                     /old_locus_tag="SAMN05421812_13045"
     CDS             complement(4204..6381)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072739.1"
                     /locus_tag="CHC05_RS38840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13045"
                     /product="MMPL family transporter"
                     /protein_id="WP_089255664.1"
                     /transl_table=11
                     /translation="MATLLYRLGRASYRRRRLVVLLWLVLLVALGGAALAFKGPTSSNF
                     TMPGTESQRAIDSLRQEFPEGAGAVGLIVVAAPEGRTLTDGPLTQAVHEVVEEAKQLPG
                     VVGAVDPFQSKAISQDTRYALIQVQFAERADELTEAQRTAYEETGAAAVKAGLRVGHAG
                     EVMNSPPEVGGTEAIGVAIALVVLLVTFGSLVAAGMTMLNALIGVAAGMAGLYALSSVV
                     ELTSVTPVLALMLGLAVGIDYSLFITSRHRQNLGEGVDPEEAAARAVGTAGSAVVFAGI
                     TVVIALAGLAIVGIPFLSAMGLAAAGTVAVAVLVAITLLPALLGFAGLKILPRKQRGTA
                     PQQHKEGFGFRWARLVRRGRIPVILVGILGLGALALPAADMRLALPDAGAGPEGTPARI
                     AADLVSEGFGPGFNGRITLVVSSDSADTTAAALAKVGPALDGTPNLVAVTPPTMSGDQR
                     TALLGIIPKEGPTAETTETLVHDVRAKTHGLGGADVSVTGQTAVGVDVSEKLADALPIY
                     LLIVVGLSVLLLMLVFRSILVPVKAALGFLLTVGATFGITVWIFQEGHLADLLGIGTPG
                     PLISFLPILLVGILFGLAMDYEVFLVSRMREDHVHGADAQHATISGMGHGARVVTAAAL
                     IMISVFAGFVLIDDPIIKSIGFALALGVAIDAFVVRMTIVPAVMSLLGRAAWWLPRWLD
                     RALPNVDIEGEKLRAELVEPEVREPVGAGHR"
     gene            complement(6384..6923)
                     /locus_tag="CHC05_RS38845"
                     /old_locus_tag="SAMN05421812_13046"
     CDS             complement(6384..6923)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="CHC05_RS38845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13046"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_176984862.1"
                     /transl_table=11
                     /translation="MVRIRTRDEILRVAGELFTRYGFKGTSLHDIAAEVGCSKATLLYH
                     FAHKDAILLALVEPARQSLIDLVARLAGVDDKGVRDAAIGGFIDLVLRYRREVALIYDV
                     TPQFLQEPAFVRVRELTDALVAGFAGRSADPNDQTAAKVLLAGIAAVVIDDKRDEVELR
                     PALVAVARRALIPGKD"
     gene            7060..7599
                     /locus_tag="CHC05_RS38850"
                     /old_locus_tag="SAMN05421812_13047"
     CDS             7060..7599
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CHC05_RS38850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05421812_13047"
                     /product="hypothetical protein"
                     /protein_id="WP_089255666.1"
                     /transl_table=11
                     /translation="MTAVAHPESGLQKATLTSDDLAETPWDYCRIHALAITDDEGPPDD
                     LTPEEFQEQNDLDPEAPSALELHLDLDYIVSRFDPGPMRDIRYWVAPATLTFSNVWNIS
                     GDLRSVCLPLELKSLRREPASPDGEPRWHLEGRDADLRFQASRYTLHLRKPPRYGNRVL
                     RMAERGGISFAPHPFI"
     gene            complement(7814..8146)
                     /locus_tag="CHC05_RS38855"
                     /old_locus_tag="SAMN05421812_13048"
     CDS             complement(7814..8146)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020525209.1"
                     /locus_tag="CHC05_RS38855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13048"
                     /product="PPC domain-containing DNA-binding protein"
                     /protein_id="WP_089255667.1"
                     /transl_table=11
                     /translation="MILIEVGAGQEVIRTLTDELAKQGVRNGAIVSMIGALEGCAISTM
                     AADDYAKDIVTEYTEPMELTGTGEVRDGAVHIHVVLGRQGDEARAGHLHWGNVNNFFVN
                     AYVIPM"
     gene            complement(8143..9189)
                     /locus_tag="CHC05_RS38860"
                     /old_locus_tag="SAMN05421812_13049"
     CDS             complement(8143..9189)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /locus_tag="CHC05_RS38860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13049"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_089255668.1"
                     /transl_table=11
                     /translation="MDNGQQLRHARRAANLTLSQVGAIGEVSASHLSRIENGERAVTPA
                     TVALYQRAVNEALGEGASPTFSAVRRKDFLALAGATVAGAVAAGPATAVDADECADWLA
                     WETWTAGRDLHETEIPPDRRPGVSLIVRRRRVVRTADGLIRFPHPGLIDFHIGRRVFAG
                     VASGSSATLETAQTTHATDLVIREFVEHDPRAVAALNRWMTDGGTDVLRVNAAGILAKV
                     AAPEIADRVIAALRVDSAARTLYVTAVASRVLAIPWDAAAKLAGGTEAPPHDSAVRLAG
                     ELRNPRDAAARWCSAVLLHQTGGAAAEPVKAAVADALRAEASRENLRTMAALLAGSNPI
                     TTTNERRR"
     misc_feature    complement(8341..8343)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9245..9260)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            9777..9911
                     /locus_tag="CHC05_RS38865"
                     /old_locus_tag="SAMN05421812_13050"
     CDS             9777..9911
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016815038.1"
                     /locus_tag="CHC05_RS38865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13050"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_089255669.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.2e-15, bitscore:
                     48.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDYLDDVSDPFELDVQIVTEGPATAALLSSTDDGCDTVKGSDC"
     gene            10001..13039
                     /locus_tag="CHC05_RS38870"
                     /old_locus_tag="SAMN05421812_13051"
     CDS             10001..13039
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287251.1"
                     /locus_tag="CHC05_RS38870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13051"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_089255670.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.6e-181,
                     bitscore: 594.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.7e-19,
                     bitscore: 60.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-26, bitscore:
                     84.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATAFRRVDAATIRISAHRWPTSLPVAWPPSGDATAILSWLRAT
                     WSTVGLADAVWTASPQFAARVEAVCSGAEQDTDRIWRVVLTLARYVVRAQRRATPFGLF
                     SGVSAVRFGTAAVVASAGVAATRVRPDAAWLASLVHQLEADPEGRRRLRVQSNNLAVVQ
                     GSRVIVQRRPHASVRGEGTCSIRYTPAVRFALSSAAAPMLWSELVDTIAAAFPESPHES
                     AQTLVSDLVDQGVLVSALRPPSTCTDPIGHVLGHLDSFQTGDGNSQRPVLLRSRAAHGE
                     AGAARPAELRALAAQMRGLARADQPLAVDLRLPDRVTLPEQVAADIVVATEILRRLTPD
                     PTGRPQWRAYRARFVDRYGTAAVVPLAEVVDPVTGLGFPTHFHSPTDQAVPLVSARDER
                     LLALAQQASIDGVREVVLDDAAVLALAGSDHLGHRVSSHVDVSAEIRAVSLGDLSAGRY
                     TVAVTGMGRSALATSGRFLDLLPSVDQERMSREFAALPVAVEGAMPAQVSFPPHNLHSQ
                     NVLRARQVLPWLISLGEYRPPAVNAIDLDDLGVAAGCDRLVLVSMSRRRVVEPTVAHAA
                     AVHTMPLIARLLVELPRATDARLVPFAWGTATCLPFLPALRYGRVLLAAARWLVDPAVL
                     PNVKVADAEWSAAFDALRHRLGLPGWVQVGHGDQRLRLNLDHAMDRALLRAHLHNSPAA
                     VTITEAAGRDDFGWLSGRAHEIVLPVASTAAPVPAPAAVIARSTWPPPMPAQPIMPGSC
                     GLVSASLACDPATMDTVLIRGVPALLAEWVEPPSWWIVRLRHPVPHLRLRLHTDDYGDT
                     ARKLGRWAAVLRQQGLVGDLTLDTYQPESGRYGDEPALTAAHELFAADSRAALAQLSTT
                     VDRRVDRQALTAVSMVDLASAMLGSCDSGYEWLVAEREQPGLPPMDRAVLRQVINLHRG
                     AVPPPVRQAWQERAAAAARYADALAASGGAVSADSVLASLLHLHHIRVFGPTGPAEQST
                     HRLARQVALAASRSRRAAEAAFG"
     aSDomain        10463..10729
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CHC05_RS38870_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.40E-19"
                     /identifier="RREFam001.1"
                     /label="CHC05_RS38870"
                     /locus_tag="CHC05_RS38870"
                     /protein_end="243"
                     /protein_start="154"
                     /score="60.8"
                     /tool="antismash"
                     /translation="QSNNLAVVQGSRVIVQRRPHASVRGEGTCSIRYTPAVRFALSSAA
                     APMLWSELVDTIAAAFPESPHESAQTLVSDLVDQGVLVSALRPP"
     misc_feature    11348..11350
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13036..14304
                     /locus_tag="CHC05_RS38875"
                     /old_locus_tag="SAMN05421812_13052"
     CDS             13036..14304
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018794744.1"
                     /locus_tag="CHC05_RS38875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13052"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_089255671.1"
                     /sec_met_domain="LANC_like (E-value: 2.1e-42, bitscore:
                     136.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNALSDPALDRAAGSLAARIADELAQPPVPDFRPDDYGPRSSRW
                     YAQSLSKGAAGVAILHGVRAQTGLGEWKPVHQWLRQATADQLNNTGGAGLWFGVPAVAH
                     ALTIAMPHAHPRTLDILDHAVADLVQRRLKDAAVRLEQQARPSLAEFDLVRGLTGLGAH
                     LLRRNRDGHLLRQVLTYLVRLAEPVAAADETGAAAPGWWTTDPADREAAVPGGHANLGM
                     AHGIAGPLALLALTARQNITVPGHLDAIGRICTWLDTWRQVGPTGPWWPEKLTAAELHA
                     GQPAAPGPNRPSWCYGTPGLARAQQLAAIALDDHHRQRAAEDALIHSLNDPEQTGRVID
                     PSLCHGWAGIAATTWYAAADARSTGLASALPLIVRRLIQHADTTAPARSGLIEGNAGAA
                     LTLHTIATGTGTDIRWATSLLIN"
     gene            14314..16428
                     /gene="fxlM"
                     /locus_tag="CHC05_RS38880"
                     /old_locus_tag="SAMN05421812_13053"
     CDS             14314..16428
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020609514.1"
                     /locus_tag="CHC05_RS38880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_13053"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_089255672.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.7e-24, bitscore:
                     78.0, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 9.5e-43, bitscore: 138.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTDHEPDIEQPPDPQPTSRWRQINLTFADWQTAEHYGTTRLAPT
                     LSAAEDTGAVVAYWFIRKNNTWRLRLLPGDRLGTIYAVLAAIMNDERICRVAEPLYRPE
                     IHAFGGTEAMTVAHTLFHADSRHLLHHLATAGGSHRRELSILLATGLMRAAGLDFYEQG
                     DVWHHVAIHRRPPKAAQPSLRLIAAVKRLITATDHAPHSPLSTNPDWPNAYQHAGHELA
                     HLDRHSALTRDLRGVLTQHTLFLHNRLGINAAHTGLLAAAAANVIFEQRHPAAERRAID
                     DLASTDSRVEAMKTVNTTPEASAPAELRERLITTLKQAGHLGLPAVEDAFRTVPREQFL
                     PGVELETVYTRRQIVTKRDATGAALSSASSPSLVADMLEQLAPRPGDRILEIGAATGIN
                     AALLAHLTGPNGTVVTIELDQDLADGAAAGLDRAGYSTVEVVCGDGALGHPEHAPYDRI
                     IVTAGAWDISAEWWNQLTPSGRIVVPLRLHESGLTRCIAFDRKGTDQLFSATSPLVCGF
                     VPMRGTTEHADHHVRLDTEVVLKLDAADKPDREALGQALTHPPHKRWSGITVTDADSIH
                     HLDLWLLVHTTTAFGRLGVSDNARSSGLVTPAYRWAGAALYQGGTIAYPAFNTTNNDHH
                     ELGVIAHGPDAEPLAAYLTELLERWDAQGRPDQPTITAHRTAMAPTQTAHTGTRRHTIS
                     RPDTTLTVVF"
     gene            complement(16412..>16741)
                     /locus_tag="CHC05_RS41920"
     CDS             complement(16412..>16741)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CHC05_RS41920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_179266580.1"
                     /transl_table=11
                     /translation="PNGVPLRPAAEPGEDRNDGLDVALTGTVTELRTAIGSGEDRNQVI
                     DATNNESLRPAIASGEDRNIQWANVVGSQAVGRAQPSSQAKTTPLRGCSAAQALAPGHR
                     VRRRP"
     assembly_gap    16742..16995
                     /estimated_length=254
                     /gap_type="repeat between scaffolds"
     gene            complement(<16996..17197)
                     /locus_tag="CHC05_RS41925"
                     /old_locus_tag="SAMN05421812_13054"
     CDS             complement(<16996..17197)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CHC05_RS41925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05421812_13054"
                     /product="hypothetical protein"
                     /protein_id="WP_179266581.1"
                     /transl_table=11
                     /translation="MGLDRLRPATEPREDRNIGPTRCGPADNVFLRLATEPGEDRNTRD
                     QCIGWQAYQLLRPATEPGEDRN"
     assembly_gap    17258..17754
                     /estimated_length=497
                     /gap_type="between scaffolds"
     misc_feature    complement(18041..18051)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     assembly_gap    18233..20165
                     /estimated_length=1933
                     /gap_type="between scaffolds"
     gene            20254..>20442
                     /locus_tag="CHC05_RS42220"
     CDS             20254..>20442
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CHC05_RS42220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_218824819.1"
                     /transl_table=11
                     /translation="MVAILARLGGRAQQPSPWVQRASSWWLRSSPGSVAGRSARRPCPH
                     GREPLVAILARLGGRAQR"
ORIGIN
        1 ccgggtacga ggacggcaac agcgcctgcg actcgtcgaa gagccggcgg gcgttggcct
       61 gcgggctgtt cgacagactc tcggtgtcgt cggtcgtgcc gtagagccag ctgttgcgcg
      121 acgacagggt cagcttctgc acgaactggt cgttggcgta gaggctgatc gtcgccgtgg
      181 tgccgccacc gctcgcggag tccgggatcg agttgcgcac cacgatcgag ttcgtctgca
      241 cggtcgaggt gaactgcacg tactggccct ggctggtcaa ccgcaccgac ttgcggcccg
      301 acgactcggt gccgaagttg gtgtgcccga acgtccgcag cgcgtcggcc tcgaccagcg
      361 tgccggtgta ctggccgttc tcggcctcgt acgacgtgaa cggggtggcg gcaccccgac
      421 cgaccacgat ggcctgggta cgggtgttgt tggtctcgtt ggtctccgcc accacgttgg
      481 tcgcgtcggc cgtggccgtg atggtcgcgc cgccgctggt cgccgtccag gtgccgctga
      541 cggccaccgt cgcggtggca ccggcggcga tcgtgccggt gttggtgttg agcgtcgtcg
      601 agccaacggt caggcgggtc acggacgcgg ccgcggcggt cgtgccgcgg ttgttgacac
      661 tgacggtgaa ggagactgcc gcgccgaccg ccgggttcga cgggttgttg gtgatgcccg
      721 tgacctgcag gtccggcccc ggcgcctggg cgacgacgag ctgcgccgac gccgtggcgc
      781 tgttgttggt gtcgttctgc tcgatgaccg tgttggtcgg gtcgaccacc gcgctcaccg
      841 cgtagctgcc ctgcgagcgg gtgcccgcgt tgaaggtgac ggtctgggac gcacccgccg
      901 cgagcccgcc gacgttcgcc gagccgacga ccaggccgcc gaggctgaag ttgacggtgg
      961 tcgcgccggc cgccgcggtg cccgcgttgc gcacggtcgc cgacagcgtg atcgcgctgc
     1021 tctcgttcgg ggaggccggg ctccagctca ccgagtcgac caccaggtcc gggttgggtg
     1081 ccggggtgcc gcagacctcg agctccgcga cctgaccgcc cggggcgccg gtgttggagg
     1141 tgaaccgcag ccgcacgtcc gcggccgtcg ccgagaccgg gatcgccacg acgttgttgc
     1201 cctggacgaa ctggtacgcg gtcgccgcca ccaggctggt gaaggtcgag ccggcctggt
     1261 cacgaccgag gacctggatc gtctgggtac gggtgcccca cgcgccgtcc gggttcagct
     1321 tgacgttgac gccggtgatg ccgtggttgg cgccgagggc aacggtcagg tcctgcgggt
     1381 agccgccacc gccctcccag taggtgccga gctgaccgtc gttggccttc tccggcgtga
     1441 aggtgaaggt cgagccggtc gcgctcatgg tcttgccggc ggccacgttg gtgcagcccg
     1501 gcggctgagt gccggtgcgg gtgacggtgt tgctgttgcc ggacaggttg ccggcgccgt
     1561 cgcgggcccg cacgtagtag gacacggtcg ccgtcgccgg ctgagtgtcc tggtaggacg
     1621 tcgcggtgcc ggcggtcgcg atctgcgtgc cgttgcggta gacgttgtag ccggccaggc
     1681 cgctgccgcc ggtgtcggtg gacgcgcccc agctcagcgt gatcgtggtc ccgttggtgc
     1741 tgtggctgag cgtgccgggc gtgctcggcg gcgtggtgtc accgggctgg gtgccggtgc
     1801 gggtgaccgt gttgctgttg cccgacaggt tgccggcgtt gtcccgcgcc cgcacgtagt
     1861 aggacacggt cgccgtcgcc ggctggctgt cctggtagga cgtcccggtg ccggccgtcg
     1921 cgatctgcgt gccgtcgcgg tagacgttgt agccggccag gccgctgccg ccggtgtcgg
     1981 tggacgcgcc ccagctcagc gtgatggtcg tccctgacac cgtgtacgag agcgtgccgg
     2041 gcacgctcgg cggggtggtg tccggcgtgg tgccgcccgg gccgtagacc tcgacctcgg
     2101 agagctgccc cgccggccac gcgctgttgg cggtgacgtt gatccgcacg taccgcgtgg
     2161 tggcctggtt gaacgtgatg gtcaccgagt tgccggccac ggccgggttg aacgtgtagg
     2221 tctgcgagcc ggccaggtcc gtgaacgacg tgccgttggt gctgccctgc acgctcaacg
     2281 tctgggtgcg ggtgccccag ccgctggtcg ggagcttcag cacgacccgg ttgacggtct
     2341 gggcggagcc gaggtcgacc tgcacccact cggggaacga gttgttggtg ctctcccagt
     2401 aggtgccctg gttgccgtcg acgacgttgc cggagccgta gacgtcggcg tgcccgctct
     2461 cggcggtcgc cttgccctgc gcgaggttgc ccgtgccgcc ggtgccggcg ccgtagacct
     2521 ccagctcgga cagctgcgcc gcaccccagc cggtgttggc ggagatgctc gcacgcacgt
     2581 accgggtgct ggtcgcggtg aagttgatcg tcacggtgtt gccgctgccc gggttgaagg
     2641 cctggctcgt cgggccgctc agcgtgctga acgacgtgcc gttggtgctg ccctggagcg
     2701 tgacggtctg gttgcgggcg ccccagccgg cgggcagctt gagcaccacc tggtcgatgc
     2761 tggtgctggc gccgaggtcg atctgggccc attgcggcaa cgcgccggag ctctcccagt
     2821 agctgcccgc gttgccgtcg ttgacgttgc cggcgccgaa gccgccgttg gtcgagctgg
     2881 ccgaggcggt cttgccgagc gcgaggttgg gaccaccggc cgcggaggcc ggcacctgcc
     2941 aacccacggt gaccagggcc gccgcgaggg cgacggccag aatccgggta cgtctcatcg
     3001 ctgtcctttt cgcagagggg gacggggatg cgctgcgcga aaattccaga ggtgcacgac
     3061 agagttttca tgactctgtc gcaatcttgc ggcaagttgg gcgtcaggtt accgacgtgc
     3121 tacggaaacc gtcaacacgt ggacgccaat cgatgcttcg cctggggaaa gactcggggc
     3181 ggcactcacg cggaccgccc ccgtgtgggc gttcctgacc ggcgacgccg gcctccccgg
     3241 tcgccccggt ccgcgcgggc cgctctggtg tggacgatgt ccacccgagc aatgttgaca
     3301 ccgtacacca gagtcgtgga cccttccagg gtgtcgtacc accacggtgg cctacgggcc
     3361 gcgctgatcg cggagggcct ccgggtggcg cgcaccggtg gcgccgcggc cttggggatg
     3421 cgcgagctga cccgcgcggt cggtgtctcc cccaacgccg cgtaccggca cttcgccgac
     3481 cgccaggcgt tggtgctggc ggtcgccctg gaggcgcagg acctgctggc ggacgcgatg
     3541 cgcgcccgga tcgcgccgtc ggcgtcgccc ttggaccggc tacgcgcggt cggtctcggc
     3601 tacatccact tcgcgcgtac ggaacgcggc tggttcgagc tcgccatcct gacccgcgac
     3661 gacggcccgc ccgggacgaa cggcccgttc cccgctccgt tccagctcct gctcgacgcg
     3721 ctcgacgggc tggtggcgtc gggcgggctg ccggctgctc ggcgcgcgca cgccgagtgg
     3781 gcgtgctggt cgacggtgca cggcttcgcc gacctgacca cccgcggtcc gctccgccgc
     3841 caggacccgg ccacgctgga cgcgctggcg tcctatgtgg tcgacaccgt catcgaaggc
     3901 ctgacctctg gaggatccac atgaccgacc agctcgacgc caccttcacg gccccgatcc
     3961 gggtggacgg cgcgttcccg acctacatcg aactgccggg ctcccacgaa ctcctcggca
     4021 cccgcaaacc ggtcaaggtc agcggcacga tcgacggcca cccgttcgag tcgaccctga
     4081 tgccgtcggg ccagggccca cactggctcc cggtgcgcgc ggcgctgaag aagacggtgg
     4141 gcaaggaagc cggagcggag gtcaccgtgc acctgacagc gcgccggtga cctccgctcg
     4201 gggtcagcgg tgaccggccc ccaccggctc gcggacctcg ggctcgacga gctccgcgcg
     4261 gagcttctcg ccctcgatgt cgacgttggg cagcgcccgg tcgagccagc gcggcagcca
     4321 ccaagcggcc cgaccaagca gcgacatcac ggccgggacg atggtcatcc ggacgacgaa
     4381 cgcgtcgatc gcgacgccga gcgccaacgc gaacccgatc gacttgatga tcgggtcgtc
     4441 gatcagcacg aaccccgcga acacgctgat catgatcagg gccgcagccg tcaccaccct
     4501 tgctccgtga cccatgcccg agatcgtggc gtgctgggcg tcggctccgt gcacgtggtc
     4561 ctcgcgcatc cgggacacga ggaagacctc gtagtccatc gcgagtccga acaggatgcc
     4621 caccagcagg atcggcagga agctgatcag cggcccgggc gtaccgatgc cgagcaggtc
     4681 ggccagatgc ccctcctgga agatccagac ggtgatgccg aacgtggcgc cgacggtcag
     4741 caggaaaccg agcgcggcct tgaccggcac caggatcgac cggaagacca gcatcagcag
     4801 cagcaccgac agcccgacga cgatcagcag atagatcgga agcgcgtcgg cgagcttctc
     4861 cgagacgtcg acacccacgg ccgtctgccc ggtcaccgag acgtccgcgc cgccgaggcc
     4921 gtgcgtcttg gcccgcacgt cgtgcaccag cgtctcggtg gtctcggcgg tcggcccttc
     4981 cttggggatg atgccgagca gcgcggtccg ctggtcgccg ctcatcgtgg gcggggtgac
     5041 cgcgacgagg ttgggcgtgc catccagcgc cggaccgacc ttggccagcg ccgcggccgt
     5101 cgtgtcggcc gagtcgctgg agacgacgag cgtgatccgg ccgttgaagc cgggcccgaa
     5161 gccctccgag accaggtcgg cggcgatgcg ggcgggcgtg ccctccgggc cggcgccggc
     5221 gtccggcagc gcgagccgca tgtcggcggc gggcagcgcc agggcgccga ggccgaggat
     5281 gccgaccagg atcaccggga tgcggccgcg ccgcaccagc ctcgcccacc ggaagccgaa
     5341 gccctctttg tgctgctgcg gtgccgtgcc ccgctgcttc cgcggcagga tcttgagccc
     5401 ggcgaacccg agcaacgcgg gcagcagcgt gatcgcgacc agcacggcga cagccacggt
     5461 gccggccgcg gccagaccca tcgcgctgag gaacgggatc cccacgatgg ccagaccggc
     5521 cagcgcgatg acgacggtga tgcccgcgaa gacgacggcc gagccggcgg tgccgaccgc
     5581 acgggccgcc gcctcctctg ggtcgacgcc ctcacccagg ttctggcggt gcctcgacgt
     5641 gatgaacagc gaatagtcga tgccgaccgc gagaccgagc atcagcgcga ggaccggggt
     5701 cacgctggtg agctcgacga cgctgctgag cgcgtacagc ccggccatgc ccgccgcgac
     5761 gccgatgagc gcgttgagca tcgtcatacc ggcggccacg agcgagccga aggtcaccaa
     5821 cagcacgacg agcgcgatgg cgacgccgat cgcctcggtg ccaccgacct cgggcggaga
     5881 gttcatcacc tcgccggcgt gcccgacccg cagcccggcc ttcacggcgg cggcaccggt
     5941 ctcctcgtac gcggtgcgct gcgcctcagt gagctcgtcg gcgcgttcgg cgaactggac
     6001 ctggatcagc gcgtaccgcg tgtcctggga aatggccttg ctctggaagg ggtcaaccgc
     6061 gccgacgacg ccgggcagct gcttggcctc ctccaccacc tcgtgaacgg cctgggtaag
     6121 cggcccgtcg gtcaacgtgc gcccctcggg cgcggcgaca acgatgagcc cgacggcccc
     6181 ggccccttcc ggaaactcct gccgcaacga gtcgatagcc cgctgcgact cggtcccggg
     6241 catggtgaag ttgctggacg tcggcccctt gaaggcaagc gccgcacccc cgagcgcgac
     6301 aagcaaaacc agccagagca ggacaaccag cctgcggcga cggtacgagg cgcggccgag
     6361 ccgatagagc aaggtagcca ttgtcagtcc ttcccgggga taagagcgcg acgagcaacg
     6421 gcaacgagcg cgggccgcag ctccacctcg tcgcgcttgt cgtcgatgac cacagcggcg
     6481 atgccggcca gcaaaacctt ggccgcggtc tggtcgttgg gatcggccga acgcccggca
     6541 aacccagcca cgagcgcgtc ggtcagttca cgcacgcgca cgaacgcagg ctcctgaaga
     6601 aactgcggag tgacgtcgta gatgagcgca acctcgcgcc gataacgaag aacaaggtcg
     6661 atgaaccccc cgatggcagc gtctcggacc cctttgtcat cgacgccggc gaggcgagcg
     6721 acaaggtcga tcagcgactg cctggcgggc tcgacgaggg caagcaggat cgcgtccttg
     6781 tgggcgaagt ggtagagcag ggtggccttg gaacacccca cctcagcagc gatgtcatgc
     6841 agcgaggtgc ccttgaagcc gtaccgggtg aacagctccc cggcgacccg caagatctcg
     6901 tcacgcgtcc ggatgcgaac cacccacaca ttctccctga ccgctcggtc agaacctgac
     6961 cgagcggtca gttcggtggc ccaggtcaca cgtgtgagtg acacccatcg ctgatcaaca
     7021 tctatcgccg tcaacacgct gggcggcgat aatcactgga tgacggcggt cgcgcacccc
     7081 gagtccgggc tccaaaaggc cacgttgacg tccgacgacc tggcggaaac gccgtgggac
     7141 tactgccgaa tccacgcgct agccatcacc gacgacgagg gcccacccga cgacctaacc
     7201 cctgaagagt tccaggaaca gaacgaccta gacccagagg ccccgtcggc cctagaactc
     7261 cacctggacc tggactacat cgtgagccgc ttcgacccag gcccgatgcg agacatccgc
     7321 tactgggtag ccccggcaac cctgaccttc agcaacgtct ggaacatctc cggcgaccta
     7381 cggtcggtat gcctgccgct ggagctaaag agcctgcgcc gagagcccgc ctcacccgac
     7441 ggcgagcccc gctggcatct cgagggccgc gacgcggacc tacgcttcca ggcgtcgcgc
     7501 tacaccctgc acctgcgcaa acccccgcgc tacggcaaca gggtgcttcg aatggccgaa
     7561 cgcggcggca tcagcttcgc cccacacccg ttcatctgac ggtccgcgcc agtttctgac
     7621 cgactggtca gctccccata atctcgtcga tctccgccaa gcccgaccca gcgcgttgta
     7681 ggtgctcagg cccggcagcg cacagctatc cgttcacccc cggaccttca ggtgagtcgc
     7741 gtccgctcat cgcccatgaa agtccatcta gctgcgccgg ctcggtacat cgggatccgc
     7801 tcaggtgctg ggcctacatg ggtatgacgt aggcgttgac gaagaagttg tttacgttgc
     7861 cccagtggag gtgaccggcc ctcgcttcgt cgccttgtcg gcccagtacg acgtggatgt
     7921 ggacggctcc gtcgcggacc tcaccggttc cggtcagttc catgggctcg gtgtactcgg
     7981 tgacgatgtc ctttgcgtag tcgtctgccg ccatggtgga gatcgcgcac ccctcgaggg
     8041 ctccgatcat tgacacgatg gcgccgttgc ggacgccttg cttggcgagc tcgtccgtca
     8101 gggtccggat gacttcttgg ccggctccga cctctatcag gatcatcggc gtctctcgtt
     8161 cgtcgtggtg atcgggttgg agcctgctag gagggcggcc atggttcgga gattctcgcg
     8221 ggacgcctct gctcggaggg cgtccgcgac cgccgccttc acgggttcgg cggctgctcc
     8281 gccggtctgg tggagcagca ccgctgagca ccaccgcgcg gccgcgtcac gcggattgcg
     8341 taactcgccg gcaagccgga ctgccgagtc gtgaggcggc gcttccgtcc caccggcgag
     8401 cttcgcggcg gcatcccaag ggatggccag gactcgactt gcgacggcgg tcacgtagag
     8461 cgtgcgcgct gcggagtcga cccgcagggc cgcgattacc cggtctgcga tttcaggagc
     8521 cgcgaccttc gccagaatgc cggccgcgtt gacccgaagg acatcggtac cgccgtcggt
     8581 catccaccgg ttgagggcgg cgacggctcg tgggtcgtgt tcgacgaatt cgcggatcac
     8641 gaggtcggtc gcgtgggttg tctgggccgt ttcgagggtg gcggaagatc ccgaggcgac
     8701 gccggcgaag acgcgccgcc cgatgtggaa gtcgatgagc ccgggatgcg ggaaccgaat
     8761 gagcccgtcc gcggtccgca cgaccctgcg gcggcgtacg atcagtgata cgcccggccg
     8821 ccggtccggc gggatctccg tctcgtgcag gtcgcgcccg gccgtccagg tctcccaggc
     8881 gagccagtcc gcgcactcgt ccgcgtctac ggctgtcgcc gggccggctg cgaccgcgcc
     8941 ggccactgta gcgccggcga gggccagaaa gtctttacgc ctcacggcgc taaaggtagg
     9001 cgatgcgccc tcgcccaggg cctcgttcac cgctcgttgg tagagcgcga ccgtggccgg
     9061 tgtgacggca cgctcgccgt tttcgatccg ggacagatgg ctcgcggaca cctcaccaat
     9121 ggcccccacc tgggaaagcg tgagattcgc tgcccggcgt gcgtgcctca gctgctggcc
     9181 gttgtccatg ccttccgtcc ccttgcggca actttcttgc ggcacacgtt gctgctgact
     9241 gcgggtgacg caaacgtcac cctcgaaggt aggaccacgg ggcgggcgct atgcagcgtc
     9301 gcagggtgag ttgatcgaga cgtgcggcgc cacggccccg tctcgtggtc tgtccagctc
     9361 acacggtagg ccagtgcccg ggacgtgtcg atacgccccg cgtgcgccat cagacccggg
     9421 gagacggaaa tggcggtttg tctagtgcgt cgcggaccac gcattgttgc ggccaggtgc
     9481 agctggagcc agggacgccc cgctgccacg tccgcgtcgt tcgaatgtcg tggttgagct
     9541 cggatgccgg cccgaatcgt caggacgctg gccatgcgat gggcaggtgc gcgtgcggat
     9601 caggtgtggc tgtctcgagt gatagcagga atccaagcca gttcgtgcct atggcagacg
     9661 ccgacaagac cccttcgctc gattcgtttc gcgtcttggt cgcggcacat cgtcatcgcg
     9721 ccggtagctg cgggggctac ccgcccgtca cctggaatcc cctttggagg gaaggcatga
     9781 acgactacct cgacgacgtc agtgacccgt tcgagctcga cgtgcagatc gtcacggaag
     9841 gtcctgcgac ggcagcgttg ctgtccagca cggacgacgg ctgcgacacg gtgaagggca
     9901 gcgactgcta gtcccaccta cgtgccggcc cgctcggcga cccgaacccg atcgggccgg
     9961 cacatgcccc gaacgccgac gattagggag gtgcccgact atgagcgcca ccgcatttcg
    10021 aagggtcgat gccgcgacga tccgcatctc cgctcatcga tggccaactt ctcttccggt
    10081 cgcttggccg ccaagcggtg atgccacagc gatcctcagc tggcttcggg cgacgtggtc
    10141 gacggtcggg ctggccgatg ccgtctggac cgccagcccg cagttcgccg cccgggtgga
    10201 ggcggtttgc tcgggcgcgg agcaggacac agatcgcatc tggcgggtcg tgttgacgtt
    10261 ggcccgatac gtcgtgcgag ctcagcgtcg ggcgacaccg ttcggactgt tctccggcgt
    10321 atctgccgta cgtttcggca cggccgcggt agtcgcgtcc gcgggggtgg cggctacgcg
    10381 ggtacgcccg gacgcagcct ggctcgcatc gctggttcac caacttgagg ccgatccgga
    10441 gggtcgccgc cgcctgcgag ttcagtcgaa caacctggcc gttgtgcagg gatctcgcgt
    10501 catcgtgcaa cgacggccgc acgcgtcggt gcggggagag gggacctgct cgattaggta
    10561 cacgccagcg gtgcggtttg cgctttcttc ggccgcagcg ccgatgctgt ggtcggagct
    10621 ggtcgacacg atcgccgcag cctttcccga gtctccccat gagtccgcgc agacgctggt
    10681 ctccgatctc gtcgaccagg gcgtgttggt ctccgcactg cgaccgccgt cgacctgtac
    10741 ggaccccatc ggtcatgtcc tcggccacct cgacagcttt cagaccggtg acggcaacag
    10801 ccagcggcca gtcctgctga gatcgcgcgc cgcgcatggc gaggcagggg ccgcgcggcc
    10861 ggccgagctg cgtgcccttg ccgcgcagat gcgcggcttg gcaagagctg accaacctct
    10921 tgcggtcgat ctgcggctcc ccgatcgcgt cacgcttccc gaacaggtag ccgccgacat
    10981 cgtggtggca acagagatcc tgcgacggtt gacgccggac ccgacaggtc ggccgcagtg
    11041 gcgcgcctac cgcgcccggt tcgtcgaccg ctacgggacg gccgctgtcg tccccctcgc
    11101 ggaggtggtc gatcccgtca ccggtctggg gttcccgacg cactttcatt caccgaccga
    11161 ccaggccgtg ccattggtgt cggctcgaga cgagcggttg ttggcgctgg cacagcaggc
    11221 gtcgatcgac ggcgtacgtg aggtcgtact cgatgacgcg gccgtgctgg cactggccgg
    11281 ctccgaccac ctcggtcacc gcgtcagctc acacgttgat gtctcggccg agatacgggc
    11341 ggtctcgtta ggcgacctct cagccgggcg ttacaccgtc gcggtgaccg ggatgggccg
    11401 gtcggcgctg gcgacgtcag ggcggtttct tgatctgctg ccttcggtgg accaggaaag
    11461 gatgagccgg gagttcgccg ccctgccggt ggccgtcgag ggagcaatgc cagcgcaggt
    11521 gagctttcct ccgcacaacc tccactcgca gaacgttctg cgtgccaggc aggtactccc
    11581 gtggctgatc tcgctcggcg aatatcgccc tccggcggtg aacgcgatcg acctcgacga
    11641 tctcggggtc gcggccggct gcgatcggct cgttctggtg tcgatgtcac gccggcgggt
    11701 ggtcgaaccc accgtggctc atgccgccgc ggtgcacacg atgcccttga tcgcccggct
    11761 tcttgtcgag ctgccacggg ccactgatgc gcggctcgtc ccgttcgcct ggggaacagc
    11821 gacgtgcttg ccgtttctgc ccgcgttgcg gtacggacga gtcctgctcg ccgctgcgcg
    11881 atggctcgtc gatccggccg tcctgccaaa cgtcaaggtc gcagacgccg aatggtcggc
    11941 tgcgttcgat gcgctacgcc acaggctcgg cctgccgggg tgggttcagg tcggtcacgg
    12001 cgatcagcgg cttcgactca acctggatca cgcgatggac cgggcactcc tgcgcgccca
    12061 cctgcacaac agcccggcag ccgtcacgat cacggaggcg gcaggccggg acgacttcgg
    12121 ctggctgtcc ggccgggcac acgagatcgt gctgcctgtc gcctccaccg ccgcgcccgt
    12181 cccagcgcca gccgcagtga tcgcacggtc gacgtggccg ccgcctatgc cggcccagcc
    12241 gatcatgcca ggatcttgcg gcttggtgtc ggcgtcactc gcctgcgatc ccgccacgat
    12301 ggacacggtg ctgatacgag gggtgccggc actgctcgcc gagtgggtcg agccgccatc
    12361 gtggtggatc gtgcgtctgc gacatccagt cccgcatctg cggcttcgcc tgcacaccga
    12421 cgactacggt gacaccgctc gcaagctcgg tcggtgggcc gccgtgcttc gacagcaggg
    12481 gcttgtcgga gacctcacgc tggacaccta tcaaccggag tccggacggt acggcgacga
    12541 gccggcgctg acggccgccc acgagttgtt cgccgccgac tcccgcgcgg ccctggctca
    12601 gctgagcact acggtcgacc gccgcgtcga caggcaggcg ctgaccgccg tcagcatggt
    12661 cgacctggcc tccgcgatgc tcgggagctg cgacagcggc tacgaatggc tggtcgctga
    12721 acgagagcag ccaggactgc cgcccatgga cagagcggtc ctgcgccagg tcatcaacct
    12781 ccatcgaggc gccgtgccac cgccagtccg ccaagcgtgg caggaacggg ccgcggcggc
    12841 cgcccgctac gcggacgcgc tcgccgcctc cggcggggct gtttccgcgg actcggtgct
    12901 cgcctcgctg ctccacctgc accacatccg tgttttcggc ccgaccggcc ccgccgagca
    12961 gtcgacccac cggctcgcgc gccaggtcgc gttggctgca tcgcgctcac gccgcgcagc
    13021 tgaggcggcg ttcggatgac caacgcgcta tctgatcccg cactcgatcg tgcggccggc
    13081 agcctggccg cccgcatcgc ggacgagttg gcccagccgc ccgtaccgga cttcaggccg
    13141 gatgactacg gcccacgaag tagtcgctgg tatgcccaat cactgtccaa aggggccgcc
    13201 ggggtcgcca ttctgcacgg cgtacgcgca cagacgggcc tcggagaatg gaagccggtc
    13261 caccagtggc tgcgacaagc cacggccgac cagctgaaca acaccggcgg agccgggctc
    13321 tggtttggtg tccccgccgt cgcccacgct ttgacgatcg ccatgccgca cgcccacccg
    13381 cgcactctcg acatccttga ccacgccgtc gccgacctgg tgcagcgccg gctcaaggac
    13441 gccgcggttc gtctcgagca acaggcacgg ccgtcgctgg cggagttcga cctcgtacgc
    13501 gggctgaccg ggctgggtgc ccacctgctg cgccgcaacc gcgacggaca cctcttgcgc
    13561 caggtgctga cctaccttgt gagactcgcc gaacccgtcg ctgccgccga cgaaactggc
    13621 gcagccgccc ccggctggtg gaccaccgac ccagccgacc gcgaagccgc tgtgcccggc
    13681 gggcacgcca acctcgggat ggcacacggc atcgccggcc ctctggcgtt gctggccctc
    13741 acagcgcgcc agaacatcac cgtccctgga cacctcgacg cgatcggccg catctgtacc
    13801 tggctggaca cctggcggca ggtcggcccg actggaccat ggtggccaga gaagctcacc
    13861 gccgctgaac ttcacgccgg acaaccagcc gcgcccggac cgaaccgacc ctcctggtgc
    13921 tacgggaccc cgggcctggc ccgcgcccag cagctcgccg cgatcgccct cgacgaccac
    13981 caccggcaac gggcggcaga ggacgccctc atccactctc tgaacgaccc cgagcaaacc
    14041 ggccgcgtca tcgatccgtc gctgtgccac ggctgggcag ggatcgcggc cacgacctgg
    14101 tacgccgccg ccgacgcccg ctccaccggc ctcgccagcg ccctgccact gatcgtgcgg
    14161 cggctgatcc agcacgccga caccaccgcc ccggcgcgat ccggcctcat cgaaggaaac
    14221 gcgggagcgg ccctcaccct ccacaccatc gccaccggca ccggcaccga catccgctgg
    14281 gccaccagcc tactgatcaa ctaggagacc gccgtggaca ccgaccacga gcccgacatc
    14341 gagcaaccac ctgacccgca gccgaccagc cggtggcgtc agatcaacct caccttcgcc
    14401 gactggcaga ccgccgagca ctacgggacg acacgactgg ccccgaccct gtcagcggcc
    14461 gaagacaccg gcgccgtcgt cgcgtactgg ttcatccgca aaaacaacac gtggcggctg
    14521 cgattgctac ccggcgatcg gctcggaacc atctatgccg tcctggccgc gatcatgaac
    14581 gacgaacgca tctgtcgcgt cgccgaaccc ctctaccggc ccgagatcca cgccttcggc
    14641 ggcaccgagg ccatgaccgt cgcccacacc ctcttccacg ccgacagccg ccacctgctc
    14701 caccacctcg cgaccgccgg cggcagccac cgccgcgaac tcagcatcct gctcgccacc
    14761 ggcctcatgc gcgccgccgg actcgacttc tacgaacagg gcgacgtctg gcaccacgtc
    14821 gccatacacc gtcgaccgcc gaaggcagcc cagccgtcac tccgcctcat tgccgccgtc
    14881 aagcgactga tcaccgccac cgaccacgca ccccatagcc cgctgagcac aaaccctgac
    14941 tggccgaacg cgtaccagca cgcgggccac gagctggcgc accttgaccg ccacagcgcc
    15001 ctgacccgcg atctgcgcgg tgtcctcacc cagcacacgc tgtttctgca caaccgactc
    15061 ggtatcaacg ctgctcatac cggtctgctc gccgcagcgg ccgcgaacgt catcttcgag
    15121 caacgccacc cggcagcaga gcgccgcgcc atcgacgacc tggcgagcac cgacagtagg
    15181 gtagaagcga tgaaaacggt caacacaacc ccggaagcgt ccgctcccgc tgagctccgc
    15241 gaacgcctga tcacgacact caaacaagcc ggccacctcg gcttgccggc cgtcgaagac
    15301 gcattccgca ccgtgcctcg cgagcagttc ctccctgggg tcgagctgga aaccgtctac
    15361 acccggcgcc agatcgtgac caagcgagac gccacgggag cggcgctgtc atctgcgtcg
    15421 agccccagcc tcgtcgcgga catgctcgaa caactcgccc cacgccccgg tgaccgcatc
    15481 ctcgaaatcg gcgccgccac cggcatcaac gccgccctcc tcgcccacct gaccggcccg
    15541 aacggcacgg tcgtcaccat cgaactcgac caggacctcg ccgacggggc cgccgcaggc
    15601 ctggaccgtg ccggctactc caccgtcgag gtggtgtgcg gagacggcgc cctcggccac
    15661 ccggaacacg cgccctacga ccggatcatc gtcaccgccg gagcctggga catcagcgcc
    15721 gaatggtgga accagctcac acccagcggc cgcatcgtcg tacccctgcg cctgcacgaa
    15781 agcggactga cccgctgcat cgccttcgac cgcaagggca ccgaccaact cttcagcgct
    15841 acatcaccgc tggtctgcgg attcgtcccc atgcgcggca ccaccgagca cgctgatcat
    15901 cacgttcggc tcgacaccga ggtagtcctc aaactcgacg ccgccgacaa acccgatcgc
    15961 gaagccctcg gccaggcgct cacgcatccg ccacacaagc gctggtccgg catcaccgtc
    16021 acggacgccg actccatcca ccacctcgac ttgtggctac tcgtccacac caccacagca
    16081 ttcggccgcc tcggcgtgag tgacaacgcc cgatccagcg gcctggtcac ccccgcctac
    16141 aggtgggccg gtgccgctct atatcagggg ggcaccatcg cttacccagc cttcaacacc
    16201 acgaacaacg accaccacga actcggcgta atcgcccacg gacccgacgc cgagccactc
    16261 gccgcctacc tgaccgaact gctcgagcga tgggacgcac aagggcgacc cgaccagccc
    16321 actatcaccg cccatcgaac cgcgatggca cccacccaaa ccgcccacac tggcacccga
    16381 cggcacacca tcagccgtcc ggacaccaca ctcacggtcg tcttctgact cgatgcccgg
    16441 gagcgagcgc ttgggccgct gagcacccgc gaagtggcgt agttttcgcc tggctcgatg
    16501 gctgggcgcg gccaacagcc tggctgccaa cgacgttcgc ccattggatg ttgcgatcct
    16561 cgcctgacgc gatggccggg cgcagcgatt cgttgttcgt ggcgtcgatg acctggttgc
    16621 gatcctcgcc cgacccgatg gccgtgcgca gctcggtgac ggtgccggtg agagcgacgt
    16681 ccaggccgtc gttgcgatcc tcgcccggct cggcggccgg gcgcagcggt accccgttcg
    16741 gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16981 nnnnnnnnnn nnnnnagttg cgatcctcgc ccggctcggt ggccgggcgc aggagctggt
    17041 aggcctgcca gccgatgcac tggtcgcggg tgttgcgatc ctcgcccggc tcggtggcca
    17101 ggcgcaggaa cacgttatcg gcggggccgc accgggtcgg cccgatgttg cgatcctcgc
    17161 gcggctcggt ggccgggcgc agccggtcga ggcccaccag gtggcgagcg acctcggccc
    17221 gttgcgatcc tcgcccggct cggtggccgg gcgcagcnnn nnnnnnnnnn nnnnnnnnnn
    17281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    17341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    17401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    17461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    17521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    17581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    17641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    17701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnacggcg
    17761 cacgatcgct gcgatcctcg cccggctcgg tggccgtgcg cagccatccc ccgatggtct
    17821 cgatgctgtg ccgcgtgccg ttgcgatcct cgcccggctc ggtggccggg cgcagccgcc
    17881 gaccgcgatc gcgtacggga gcaggtgcca ccggttgcga tcctcgcccg gctcggtggc
    17941 cgggcgcagc ccgcgtcgga tgacgacgac cgttcggccg tcccgctggt tgcgatgctc
    18001 gcccggctcg gtggccgggc gcagcgcgat cgagtccttc gtgaccttgc acagggcctc
    18061 gatgttgcga tcctcgcccg gcttgtggcc gggcgcagcg cctgcgccgc ctccacaagg
    18121 gaccagggcc gctgcaagtt gcgatcctcg cccggctcgg tggccgggcg cagcgctgat
    18181 cgcgcagggc atcacacccg ccatggccgc cgttgcgatc ctcgcccggc tcnnnnnnnn
    18241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    18961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19741 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19801 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19861 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    20041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    20101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    20161 nnnnngatcg ggtcggggtt gcgatcctcg cccggctcgg tggccgggcg cagcaacctc
    20221 tccgagagcg gccatccgcg cggtagcact ggcgtggttg cgatcctcgc ccggctcggt
    20281 ggccgggcgc agcagccctc gccgtgggtg cagcgggcca gctcgtggtg gttgcgatcc
    20341 tcgcccggct cggtggccgg gcgcagcgcc cggcgtccgt gtccgcatgg ccgcgaacca
    20401 ctggttgcga tcctcgcccg gctcggtggc cgggcgcagc gc
//
