LOCUS       NZ_FZPH01000012        23033 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Asanoa hainanensis strain CGMCC 4.5593, whole genome shotgun
            sequence.
ACCESSION   NZ_FZPH01000012
VERSION     NZ_FZPH01000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Asanoa hainanensis
  ORGANISM  Asanoa hainanensis
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Asanoa.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900188485.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 02:44:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,204
            CDSs (total)                      :: 8,124
            Genes (coding)                    :: 7,995
            CDSs (with protein)               :: 7,995
            Genes (RNA)                       :: 80
            rRNAs                             :: 2, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 129
            CDSs (without protein)            :: 129
            Pseudo Genes (ambiguous residues) :: 0 of 129
            Pseudo Genes (frameshifted)       :: 20 of 129
            Pseudo Genes (incomplete)         :: 110 of 129
            Pseudo Genes (internal stop)      :: 8 of 129
            Pseudo Genes (multiple problems)  :: 8 of 129
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:45:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 258334
            Orig. end                         :: 281367
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FZPH01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23033
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX) and not alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..23033
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23033
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20000:>23033](-)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..>23033)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     gene            57..746
                     /locus_tag="CHC05_RS27175"
                     /old_locus_tag="SAMN05421812_112246"
     CDS             57..746
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286590.1"
                     /locus_tag="CHC05_RS27175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112246"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_245871240.1"
                     /transl_table=11
                     /translation="MTHDVVSVAPDASYREVVNVLVDSGVSAAPVVDARGHVVGVVSEA
                     DLLHKVEAVGDEAHRRHFAGRRRSHALTVGAVAADLMTAPAVVIAPDASIAAAARRLES
                     ERIKRMPVVDVQRRLVGIVSRRDLLWIHTRTDADVRSEIVDHVLLRTLWIDPAAVEVDV
                     VDGVVSLAGRLESRSLAGLVASLVSKVAGVVEVIDRLAWDQDDSRVVRAAGYPFGTPER
                     LMRPSTN"
     gene            complement(807..1487)
                     /locus_tag="CHC05_RS27180"
                     /old_locus_tag="SAMN05421812_112247"
     CDS             complement(807..1487)
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012383.4"
                     /locus_tag="CHC05_RS27180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112247"
                     /product="phosphoribosyltransferase family protein"
                     /protein_id="WP_089253403.1"
                     /transl_table=11
                     /translation="MAFRDRADAGRRLANRLDHLRGCDAVVLGVTRGGVPVALEVARAL
                     DLPLDVVVVERIQDPFVSAVTLGAVAEGGISVFDDSALSSAWISEGAFGALVAGLVAEV
                     ERRARAVRAGRASLMLARRTALLVDDGVATGATALAAVRTVRARGAQRVVLAVPVAEAD
                     AMASLDDEVDETVCVDRQPWVPSIGRLYREYPPTTYEEVAEILHRAGIRSPYRGPRSAS
                     DRAA"
     gene            complement(1853..2185)
                     /locus_tag="CHC05_RS42720"
     CDS             complement(1853..2185)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CHC05_RS42720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_245871241.1"
                     /transl_table=11
                     /translation="MPVITAEQTRTLLGACASRSFMDLRDQAIIRLFYNTGGPPRFGGR
                     VSLVVVFVDDDRDRRCLRVCHGDPLVLSSPSVRPLTQATGRGQGPARDGTTCRRAGAGR
                     GVEPRM"
     gene            complement(2228..2575)
                     /locus_tag="CHC05_RS42725"
                     /old_locus_tag="SAMN05421812_112248"
     CDS             complement(2228..2575)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CHC05_RS42725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05421812_112248"
                     /product="phage integrase N-terminal SAM-like
                     domain-containing protein"
                     /protein_id="WP_245871242.1"
                     /transl_table=11
                     /translation="MPTIDIRKITAGLSPTWSGYLRDWDRTLRAANHPETTRYSYLLAA
                     AQLGRYLATECDEFDAAEAADDPCLVGRGHIEGFQAWMVDIRSASIALNKHKCLQQFFK
                     WLTLDEEAIRR"
     gene            complement(3044..3337)
                     /locus_tag="CHC05_RS42730"
                     /old_locus_tag="SAMN05421812_112249"
     CDS             complement(3044..3337)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CHC05_RS42730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05421812_112249"
                     /product="hypothetical protein"
                     /protein_id="WP_245871243.1"
                     /transl_table=11
                     /translation="MACAQGNAILALEVQVDDDPRQAAVVRPEPNLDTRVQWIYPWQAT
                     LGTHTLRVRAVDRTAPADVRVALMHDGSEFVGVYRAGVALQRDTATPCRGGP"
     gene            3995..4828
                     /locus_tag="CHC05_RS27195"
                     /old_locus_tag="SAMN05421812_112250"
     CDS             3995..4828
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018823369.1"
                     /locus_tag="CHC05_RS27195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112250"
                     /product="metallophosphoesterase"
                     /protein_id="WP_089253404.1"
                     /transl_table=11
                     /translation="MRPGVYAISDLHVGFRDNRTIVEELRPRHPEDWLLVAGDVGDYAS
                     DVAWTFATLRRNFGTVIWAPGNHELWTLPDDPVQLRGVERYEHLVSVARQLGVRTPEDP
                     YAVWRGSDGPVTVAPLFLLYDYTFRPAGCPDAASAIARAYAAGVVCTDEVFLHPDPHAT
                     RQEWCAERLRLTEQRLSRCDPSIPTLLVNHFPLVRQPTLALRHPEFAIWCGTDRTSDWH
                     LRFGACAVVYGHLHIPRSTRYDGVPFEEVSVGYPYEWRRRHGGSPAAKAILPPPE"
     gene            5361..7049
                     /locus_tag="CHC05_RS27200"
                     /old_locus_tag="SAMN05421812_112251"
     CDS             5361..7049
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012312.4"
                     /locus_tag="CHC05_RS27200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112251"
                     /product="MFS transporter"
                     /protein_id="WP_179266398.1"
                     /transl_table=11
                     /translation="MPSSDSGEVGEASSVWQRWNRRSSSGASFEHPFAFWLGITITTVG
                     VILQLPMYFMAGMEHYHLAGMPVTTEMAIGMVMLFIGVGLTAWGLYPKQVPGTAKMSKV
                     RVGALDDAPIRPAHIALLLVLAAAITIDVMKPVSFAFLAPGAAMEYGLKSPLNPGSDAL
                     PIGLYPLSGITGTMIGSFIWGYLGDRIGRRASILLAGVIFIATSTCGTMPEYWMNLITC
                     FAMGLGVGGMLPITFALMSEAVPKRHRGWMMVLIGADIAGAYIIVSWLSATLASPDQFG
                     WRMLWLIGLPTGLILLVLNRWIPESPRFLLQQGREEEARAVMRRYGAVIIEDTESELVV
                     EKNLHGNFRQLFTGPFIGLSAALVLLALSIGMTQYGFQQWMPSNLQKLGFSEVASSELL
                     RNAALIGFPLSVPIALLYGFWSSKKTVIMVTALMGAALAAFATLGDNVVNNRTLLYVLL
                     VVPVWGVSILNSVLAAYSAEVYPTVVRARGSGLSAGATKLGGVLILATVVVAIAAPSVR
                     ITAALGVIPMALALIVLMIYGPETRHKQLESITAEELNVRSAAVG"
     misc_feature    6945..6947
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7042..7557
                     /locus_tag="CHC05_RS27205"
                     /old_locus_tag="SAMN05421812_112252"
     CDS             7042..7557
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016843.4"
                     /locus_tag="CHC05_RS27205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112252"
                     /product="HPP family protein"
                     /protein_id="WP_144022793.1"
                     /transl_table=11
                     /translation="MGKSTTARRAELFGGLRGRFREALLDAGIATVGGTLGIAAIVALG
                     VVFSNPLLIAPFGSTCMMIFGAPETPFARPRNVLGGHLICTATGLAALEWLGDRAWVAA
                     IAVGVAMGLMKLTRTFHPPAGGDPIVVILSSPAWLFVVVPVLLGCVTLICVAFVFHKLS
                     KRASYPLW"
     misc_feature    complement(7686..7701)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.12"
                     /tool="antismash"
     misc_feature    7728..7746
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.53"
                     /tool="antismash"
     misc_feature    7976..7994
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.14"
                     /tool="antismash"
     gene            8325..9530
                     /locus_tag="CHC05_RS27210"
                     /old_locus_tag="SAMN05421812_112254"
     CDS             8325..9530
                     /EC_number="2.8.2.-"
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050656 - 3'-phosphoadenosine
                     5'-phosphosulfate binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_3: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024860.4"
                     /locus_tag="CHC05_RS27210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112254"
                     /product="sulfotransferase"
                     /protein_id="WP_089253407.1"
                     /transl_table=11
                     /translation="MTKAFSGFSDKPLAAAAGEPALDPTRLAELAATRGGVLPATSRFL
                     PGLVRLCEALEKEAALTPSGRVSAQRSLVNALVTQADLHRLQSGRPQVRRQPVGRPLFI
                     TGLHRSGTTLLQWLLSRHPQVRAPRLWELLAPSAASAPDELVGAADGYVRDYHRAAPTF
                     AAIHPLSATEPEECHRLLGNAFLSEIYALRFHIPSYMDWLGSQDREPAYQFHLEQLRAI
                     LWRVPGEQVVLKCPFHLWHGGALRRVYPHARVVRLHRDPVEAIASACSLTRAVRAARSD
                     AVDPLAIGDFWIDRARSGVARLADLGPTANGGLPTLDLRYRDLIADPIAAVRRVCRFLR
                     LPLSAEIEGRIQAALRSGHLRKQSEHTYRLQDFGLRPARLEAMFADYRVSLDLASRRVL
                     SP"
     misc_feature    complement(8330..8341)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.7"
                     /tool="antismash"
     gene            9623..10849
                     /locus_tag="CHC05_RS27215"
                     /old_locus_tag="SAMN05421812_112255"
     CDS             9623..10849
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1282:
                     extracellular ligand-binding receptor"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020217514.1"
                     /locus_tag="CHC05_RS27215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112255"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_089253443.1"
                     /transl_table=11
                     /translation="MSLVRVEVDAVNEHAGDDPIKIGIVSPMSRPGDAMAGVLVSRGAR
                     LGAEYLREHGGVLGGRNVRLIAYNDMATATEDGFAKSAVAQMAKLAFVDDVIAALGQWH
                     LRTTDPVANLCEAVGLPMFVENGHSTVTRGRRSIFRTYFSIADRAPLMMDCLKGTGARR
                     VAILAADTVFGQTMANTLQQEGEARGLEFLRIDFEQEVVVDWRDDLRRIKEWQPDVFIN
                     GGLNVIAGGGPVGNSYHILQQAIEVGLLPGVAMMVTFGFPMRSLDYWRMAGEPGNGVMW
                     PATKFRPSWPEMTAIGRWFTERFTERYGFAPPDTCLSAFTDVTIIGQALDHAGTYSRAA
                     LLDALEEAEFDTWRGPLRFERGQHHNPPELVIMQYQTPNQTFDEAAIIHPPSLADSKYL
                     PPNVTVESA"
     gene            10852..12552
                     /locus_tag="CHC05_RS27220"
                     /old_locus_tag="SAMN05421812_112256"
     CDS             10852..12552
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018827973.1"
                     /locus_tag="CHC05_RS27220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112256"
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_179266399.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2e-48, bitscore:
                     158.3, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.6e-40, bitscore:
                     130.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPTRSAAGSVADTLVAGLRAQGVDRVFCVAGESYLPILDRLYDT
                     AEIEVVTCRHEASAAFAAVADAKLTGHAGVCLVSRAPGATNAAIAAHSAAEDATPLVLI
                     VGDVSTDERGRDSFQEIDCGQLFGGFTKGVWQLAHPPAAAEFLGRAFRVAESGTPGPVV
                     LTVPEDVLYQRDPGPMSLTPVLAASATVRSADLAAVASTVRRARRPLLVAGGLLGSAKA
                     RATLRETSERLLLPILTSNKHQDLFDNRHPHYAGHLHNNTQAGQRALFERADVVLAVGT
                     RLDATTTLGHRFPSGSVPDQALIHVYPDPARLGARHRPAIALAADPGTFLGSLAQTDPP
                     TDPARVDWIDELHAFEVEKGRWQQHQADDGVPFGAVITALDDVTGGDIVVTVDSGTFTS
                     WLYRYLRLTGNARMLGVTSSAMGFGVPAAVAAAMRLRRPVVAVVGDGGFLMTGSELATA
                     VAHDLPLIVLIANNASYGTIRLHQERTYPGRVIATDLRNPDFARLAEAYGCLGLSIAEE
                     ADVAPVLRRAMGHGGPVVVDVRTSLQWITAYRRLALTQPLVAATSPRSL"
     gene            12552..13967
                     /locus_tag="CHC05_RS27225"
                     /old_locus_tag="SAMN05421812_112257"
     CDS             12552..13967
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018742048.1"
                     /locus_tag="CHC05_RS27225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112257"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_089253409.1"
                     /sec_met_domain="PALP (E-value: 2.7e-64, bitscore: 211.4,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHYQNSLLELIGNTPLVRLKRVAAGLPATVLAKVEYLNPGGSVKD
                     RIAVRMVEAAEADGRLRPGGTIIEPTSGNTGVGLAIVAQEKGYRCLFTCPDKVAADKIR
                     VLRAYGATVVICPATVPVDDPRSYRSVAARLERETQGAVLLDQYSHPENPRSHYLGTGP
                     ELWRQTDGRITHFVAGIGTGGTISGAGAYLKKVSHGRVRIIGADPEGSIYSDPEGPVRP
                     YLLEGVGQPQLPRSYDPTVPDEIIRVSDHEAITMTRRLAREEALLTGGSCGMAAVAALR
                     VAERLTPDDLVVVLLPDSGRGYLAKIFDDQWVARLGLFDDPADTGPRLRELLPLSVERP
                     RAIVLQPEVSLLRAATLLDHYPGGTHIVVTAGAPPLRLAEVVGLVAAHTLRDALTDPRR
                     SAIDPISSVATVRPHVGAGQSASAAACHLDAHDAAVVIERGFVCGVVTGDELDDLTRAD
                     TARTSRETALETT"
     gene            13964..15115
                     /locus_tag="CHC05_RS27230"
                     /old_locus_tag="SAMN05421812_112258"
     CDS             13964..15115
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012183082.1"
                     /locus_tag="CHC05_RS27230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112258"
                     /product="Glu/Leu/Phe/Val dehydrogenase dimerization
                     domain-containing protein"
                     /protein_id="WP_089253410.1"
                     /transl_table=11
                     /translation="MSTVLEYVDPLEGFRGWLVYDGGSCRIAAGGCRVQQGLTRDTLVS
                     LASRMTLKERLLGINVDGAKCGIDYDPRSPGKAAAVRRFLAFLREELVHRFSMGSDMGT
                     RWDELERLAAAEGIPSIKYAVRRAQEFTDDEFFARLRTLQAPVGALTLAQRRAGHALAE
                     AAVGAARAAGLGPRATCALQGFGNLGRAAACTLAEVGMTVVAVSDEFGCVADHHGLDIP
                     GMLAAPFGTPVQASVRRGEQLPSTALFKIPADISILAATENAISLPQVGELPTPVVVVG
                     ANCGLTPDVEAALDRAGVLVIPDFVGGIGGSASVEALFGPEHRPTEVHVLGGVTQIMRQ
                     LVDHLISEARRRGTSARSVALHLAQTTIPVPDRRPYGRSRFLA"
     gene            15162..16565
                     /locus_tag="CHC05_RS27235"
                     /old_locus_tag="SAMN05421812_112259"
     CDS             15162..16565
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012183083.1"
                     /locus_tag="CHC05_RS27235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112259"
                     /product="adenylosuccinate lyase family protein"
                     /protein_id="WP_089253444.1"
                     /transl_table=11
                     /translation="MTADRPTTSTCRHPRGHITDSRFYGDRFATPASRRIFCDICRKQR
                     WLDIEAALATVQAELGMIPAAAAEGIVAAAKLEFIDLDAVEAETNRTGHSLIGLLRVLQ
                     DACPEGSGEFIHFGATTQDIQDTGQVLEMRDVLDDLDTTLRAIVHRLVELAEEHTETVA
                     VGRTHARAALPMAFGLKIASWLDEVLRHVERIADLRNRALVAQLFGGAGTMAGFGDLGL
                     VLVERFADRLGIGVPTIGWHVARDRVVDYVTTLAMLAGTMGRIAEEVRILGRPEFGEVS
                     EAWQYGKVGSSTMPHKRNPERCEQTVVMAKLAAGQAAVAYGAMVGDHERDSRALRVEWA
                     CVPDVSHYCLAACEIGREILEGLTVHPERLSLNVREVADQIASERLMLALGEHLGKQTA
                     HERVYEISQRAFEVDSTIREVFRETEDLRDMLDDATLDAIFNPSGYLGASTALTLRAVA
                     EGRKWLSNR"
     gene            complement(16579..17331)
                     /locus_tag="CHC05_RS27240"
                     /old_locus_tag="SAMN05421812_112260"
     CDS             complement(16579..17331)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (4-178). E-value: 8.7e-09. Score:
                     27.5. Matches aSDomain:
                     nrpspksdomains_CHC05_RS27240_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012180648.1"
                     /locus_tag="CHC05_RS27240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112260"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_089253411.1"
                     /transl_table=11
                     /translation="MGRRLVVISGGGTGIGYAIADALADDDDVVIIGRRSQVLTAAAEA
                     INERIGEPRVRPVVADLTDPKAVEYAAAEAATAHGVVDVLVNNAGGNFAPHGADDLTQL
                     SEQYVTNYRSNVLPTVLLTHALLPHLRRGGGGRIITITSIAAFRGNASYGAAKAALHPW
                     SAELATQLGPDGITVNVVAPGYIGDTEFYRERMTPEFHQARSRQSLIGRGGTPTDVAGV
                     VRYLAGHGSEFVTGQVIQINGGALLGRG"
     aSDomain        complement(16798..17319)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHC05_RS27240_PKS_KR.1"
                     /evalue="8.70E-09"
                     /label="CHC05_RS27240_PKS_KR.1"
                     /locus_tag="CHC05_RS27240"
                     /protein_end="178"
                     /protein_start="4"
                     /score="27.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVVISGGGTGIGYAIADALADDDDVVIIGRRSQVLTAAAEAINER
                     IGEPRVRPVVADLTDPKAVEYAAAEAATAHGVVDVLVNNAGGNFAPHGADDLTQLSEQY
                     VTNYRSNVLPTVLLTHALLPHLRRGGGGRIITITSIAAFRGNASYGAAKAALHPWSAEL
                     ATQLGPDGITV"
     CDS_motif       complement(17257..17313)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHC05_RS27240_0001"
                     /evalue="2.40E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="CHC05_RS27240"
                     /protein_end="25"
                     /protein_start="6"
                     /score="10.6"
                     /tool="antismash"
                     /translation="VISGGGTGIGYAIADALAD"
     gene            17470..17952
                     /locus_tag="CHC05_RS27245"
                     /old_locus_tag="SAMN05421812_112261"
     CDS             17470..17952
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018742768.1"
                     /locus_tag="CHC05_RS27245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112261"
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="WP_089253412.1"
                     /transl_table=11
                     /translation="MRLSARVDYAIRAVVELAARTDPDAAPTGAALQPSVRASELAAIQ
                     DISPKYLEGILLSLRQGGVVAARRGSVGGYRLARPAKDISLADIIRIVDGPLTNIRGFR
                     PEQLDYVGPAATLQMVWIALRARERQILEGVTVAEIVRNDLPERVRSLTRDPRAWH"
     gene            18011..18772
                     /locus_tag="CHC05_RS27250"
                     /old_locus_tag="SAMN05421812_112262"
     CDS             18011..18772
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03083.1"
                     /locus_tag="CHC05_RS27250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112262"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_144022794.1"
                     /transl_table=11
                     /translation="MRLPFAPADYIQPLTDAMAGFAAIAATTDLDAPIALNKKWALAGL
                     VRHLGGIHRWAAAIVETGKRVSGAPKPPLGADLARWYQESAEALSSAIAKSRPDSTCWN
                     FTKDPRVTAFWYRRQLHETIIHGRDADAATGTIRAIPLGVAADGVDEVFTVMLPTVRRW
                     GTKLPPRLTGPVLVHATDSGHRWLLTPTDDVHPAVKRQPGATVLADATVRATADSLLMA
                     LWGRATVAEADVTVDGDVEMARAFLDARLTP"
     misc_feature    18242..18244
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18779..19990)
                     /locus_tag="CHC05_RS27255"
                     /old_locus_tag="SAMN05421812_112263"
     CDS             complement(18779..19990)
                     /EC_number="2.3.1.-"
                     /NRPS_PKS="Domain: PKS_AT (88-365). E-value: 2.1e-86.
                     Score: 281.9. Matches aSDomain:
                     nrpspksdomains_CHC05_RS27255_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012901.4"
                     /locus_tag="CHC05_RS27255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112263"
                     /product="acyltransferase domain-containing protein"
                     /protein_id="WP_089253414.1"
                     /sec_met_domain="PKS_AT (E-value: 9.2e-86, bitscore: 281.9,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAADSWHVLRLAGDDAEELERATTEAYERLRKPNASFADLRRPAD
                     SQRHRRVVLCQTVDDAVTTLRKQPSRFVRTAEAPRPAPDRIGFMFPGGGAQHAGMATQL
                     YEREPVFRGHFDDCARRFRDALDLDVHACLDPDVALSAMERPPLGLGSLFATSYALAQV
                     WLARGLRPSLLIGHSLGEYVAATLAGVLELGDAVRLVALRAQLMDGLPSGEMLIVQLGH
                     AGLEPLMRPGVSVAAINSPTQCVVSGHVEAVRALELDLAQREVTVRRLRFGAAAHSELI
                     EDVLDEFDRLARSIRTRPPSIPVVSNLSGGWLSSAEAIDPSYWTHHLRSPVRFADGLAA
                     ATGAGQVVLLEVGPGTTLSTLARQNGVSPDPVSSLRHPLDPRPEAAVFALSSGELWIRG
                     VDVD"
     aSDomain        complement(18896..19726)
                     /ASF="Neither malonyl-CoA or methylmalonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHC05_RS27255_PKS_AT.1"
                     /evalue="2.10E-86"
                     /label="CHC05_RS27255_PKS_AT.1"
                     /locus_tag="CHC05_RS27255"
                     /protein_end="365"
                     /protein_start="88"
                     /score="281.9"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="MFPGGGAQHAGMATQLYEREPVFRGHFDDCARRFRDALDLDVHAC
                     LDPDVALSAMERPPLGLGSLFATSYALAQVWLARGLRPSLLIGHSLGEYVAATLAGVLE
                     LGDAVRLVALRAQLMDGLPSGEMLIVQLGHAGLEPLMRPGVSVAAINSPTQCVVSGHVE
                     AVRALELDLAQREVTVRRLRFGAAAHSELIEDVLDEFDRLARSIRTRPPSIPVVSNLSG
                     GWLSSAEAIDPSYWTHHLRSPVRFADGLAAATGAGQVVLLEVGPGTTLSTLARQN"
     CDS_motif       complement(18989..19024)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHC05_RS27255_0004"
                     /evalue="1.30E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="CHC05_RS27255"
                     /protein_end="334"
                     /protein_start="322"
                     /score="15.3"
                     /tool="antismash"
                     /translation="YWTHHLRSPVRF"
     CDS_motif       complement(19247..19285)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHC05_RS27255_0003"
                     /evalue="1.20E-05"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="CHC05_RS27255"
                     /protein_end="248"
                     /protein_start="235"
                     /score="18.3"
                     /tool="antismash"
                     /translation="AAINSPTQCVVSG"
     misc_feature    complement(19361..19363)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       complement(19370..19489)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHC05_RS27255_0002"
                     /evalue="7.90E-21"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="CHC05_RS27255"
                     /protein_end="207"
                     /protein_start="167"
                     /score="66.3"
                     /tool="antismash"
                     /translation="GLRPSLLIGHSLGEYVAATLAGVLELGDAVRLVALRAQLM"
     CDS_motif       complement(19676..19729)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHC05_RS27255_0001"
                     /evalue="1.60E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="CHC05_RS27255"
                     /protein_end="105"
                     /protein_start="87"
                     /score="17.3"
                     /tool="antismash"
                     /translation="FMFPGGGAQHAGMATQLY"
     gene            complement(20001..>23033)
                     /locus_tag="CHC05_RS27260"
                     /old_locus_tag="SAMN05421812_112264"
     CDS             complement(20001..>23033)
                     /NRPS_PKS="Domain: AMP-binding (74-463). E-value: 1.2e-98.
                     Score: 322.3. Matches aSDomain:
                     nrpspksdomains_CHC05_RS27260_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (571-640). E-value: 5.2e-19. Score:
                     60.2. Matches aSDomain: nrpspksdomains_CHC05_RS27260_PCP.1"
                     /NRPS_PKS="Domain: TD (671-897). E-value: 1.3e-62. Score:
                     203.1. Matches aSDomain: nrpspksdomains_CHC05_RS27260_TD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: NAD_binding_4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="CHC05_RS27260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05421812_112264"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_144022795.1"
                     /sec_met_domain="AMP-binding (E-value: 2.6e-111, bitscore:
                     366.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.6e-12, bitscore:
                     40.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.8e-49, bitscore:
                     161.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GLQFRVEFATDLFDRSRVHRLMSHLELVLRAAVADPSTRVSQVPL
                     VVGEERDRMLSDWQGQHVEQTTDPVHTQIAAIHPDVVAARFQGAELTYGELDNRAGILA
                     RHLRQLGVGHQDVVAVGLERGFDLLVALVGVLKTGAAFVVMDTSHPQQRLAFVLSDTAA
                     KVVLTTSTLQPRLPEPDGWSPLRMDTDWATIEHAAAEPLPELADENSLAYVLYTSGSTG
                     KPKGVMIEHHALTTFTIWLRNLFHFGPGTRMAHHMAMIFDFAVGEIFTGLVSGATLVFV
                     PEEARLSPPALGDLLLDEHINYLGGPPAVLGAIPPHPYPELTYMIAGGEAVPPDLVNRW
                     NTAPRRFINGYGPTEAAVGCIYHECEHRTWTEQPPIGRPMPRRVAYVFDQWDNLCPVGI
                     PGEVVVGAAGLARGYLNLPELTAEKFIPDPLNPNQRLYRTGDLGVWNETGTIEFLGRID
                     TQIKLNGLRIELEEIESTLTTHPHITAAAVTVREDTPGNKQLVGYIVPTNGTINTTDLR
                     THLAEHLPRYMIPNIFVTLPKLPLTTIGKIDRNALPHPEQHTTTRTPITPRTPTEQTIT
                     DTFTETLGLPNISVDDNFFALGGTSLQAARTVLALREVTGRDVALTLLYTKPTIRDLAA
                     ALDESAGTTTSKAVAAVRETASPAALPPRAPTRFQHILLTGATGYFGAFLLDELLSGTD
                     GTVTCLVRPVRGQRAADRVIANLARFGRHRDDLAERVRVREGDLTRQRLGLSEDEFARL
                     AAQLDVIVHSGAHVDILFPYEGLEGANVDGTRRIIELATTGQLKELLLVSTVSARLGEH
                     RDPSLPGYAASKWAAERLVVAARDRGAPASVFRLPRIAGDSRTGLSNDRDAVMGLLRRF
                     LAMGVAADLRFEEEWVPADLGARALVASASRRSDGGLFTIDPPTRVRVNEVIALLAERA
                     GLPVLPRAEFMDHIAARFPDQLELMKGILATGSRTDLPAPSAEVDKGFERVEAGGPDER
                     LLRRYVDALVTSVGNQPADMK"
     aSDomain        complement(20340..21017)
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHC05_RS27260_TD.1"
                     /evalue="1.30E-62"
                     /label="CHC05_RS27260_TD.1"
                     /locus_tag="CHC05_RS27260"
                     /protein_end="897"
                     /protein_start="671"
                     /score="203.1"
                     /tool="antismash"
                     /translation="ILLTGATGYFGAFLLDELLSGTDGTVTCLVRPVRGQRAADRVIAN
                     LARFGRHRDDLAERVRVREGDLTRQRLGLSEDEFARLAAQLDVIVHSGAHVDILFPYEG
                     LEGANVDGTRRIIELATTGQLKELLLVSTVSARLGEHRDPSLPGYAASKWAAERLVVAA
                     RDRGAPASVFRLPRIAGDSRTGLSNDRDAVMGLLRRFLAMGVAADLRFEEEWVPADLGA
                     RALV"
     aSModule        complement(20340..22808)
                     /complete
                     /domains="nrpspksdomains_CHC05_RS27260_AMP-binding.1"
                     /domains="nrpspksdomains_CHC05_RS27260_PCP.1"
                     /domains="nrpspksdomains_CHC05_RS27260_TD.1"
                     /final_module
                     /locus_tags="CHC05_RS27260"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     aSDomain        complement(21111..21317)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHC05_RS27260_PCP.1"
                     /evalue="5.20E-19"
                     /label="CHC05_RS27260_PCP.1"
                     /locus_tag="CHC05_RS27260"
                     /protein_end="640"
                     /protein_start="571"
                     /score="60.2"
                     /tool="antismash"
                     /translation="EQTITDTFTETLGLPNISVDDNFFALGGTSLQAARTVLALREVTG
                     RDVALTLLYTKPTIRDLAAALDES"
     CDS_motif       complement(21609..21674)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHC05_RS27260_0003"
                     /evalue="8.50E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="CHC05_RS27260"
                     /protein_end="474"
                     /protein_start="452"
                     /score="30.8"
                     /tool="antismash"
                     /translation="FLGRIDTQIKLNGLRIELEEIE"
     aSDomain        complement(21642..22808)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHC05_RS27260_AMP-binding.1"
                     /evalue="1.20E-98"
                     /label="CHC05_RS27260_AMP-binding.1"
                     /locus_tag="CHC05_RS27260"
                     /protein_end="463"
                     /protein_start="74"
                     /score="322.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AAIHPDVVAARFQGAELTYGELDNRAGILARHLRQLGVGHQDVVA
                     VGLERGFDLLVALVGVLKTGAAFVVMDTSHPQQRLAFVLSDTAAKVVLTTSTLQPRLPE
                     PDGWSPLRMDTDWATIEHAAAEPLPELADENSLAYVLYTSGSTGKPKGVMIEHHALTTF
                     TIWLRNLFHFGPGTRMAHHMAMIFDFAVGEIFTGLVSGATLVFVPEEARLSPPALGDLL
                     LDEHINYLGGPPAVLGAIPPHPYPELTYMIAGGEAVPPDLVNRWNTAPRRFINGYGPTE
                     AAVGCIYHECEHRTWTEQPPIGRPMPRRVAYVFDQWDNLCPVGIPGEVVVGAAGLARGY
                     LNLPELTAEKFIPDPLNPNQRLYRTGDLGVWNETGTIEFLGRIDTQIKL"
     CDS_motif       complement(21756..21845)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHC05_RS27260_0002"
                     /evalue="7.00E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="CHC05_RS27260"
                     /protein_end="425"
                     /protein_start="395"
                     /score="43.9"
                     /tool="antismash"
                     /translation="PVGIPGEVVVGAAGLARGYLNLPELTAEKF"
     CDS_motif       complement(22338..22397)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHC05_RS27260_0001"
                     /evalue="1.20E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="CHC05_RS27260"
                     /protein_end="231"
                     /protein_start="211"
                     /score="36.2"
                     /tool="antismash"
                     /translation="AYVLYTSGSTGKPKGVMIEH"
ORIGIN
        1 ggtggagggg agcggagaaa ggatcagaga tgagacagtg gaccgttcag gatgtcatga
       61 cacacgacgt cgtgtcggtc gcgcccgacg cctcgtaccg cgaggtggtc aacgtcctgg
      121 tggacagtgg cgtcagcgcg gcgcctgtcg tcgacgctcg cggccacgtc gtcggagtgg
      181 tgtcggaggc agacctgctg cacaaggtgg aagcggtcgg cgacgaggcg caccggcgcc
      241 acttcgccgg caggcgccgt agtcacgcgc tgacggtcgg tgccgtcgcc gccgatctga
      301 tgaccgcgcc ggccgtcgtc atcgcgcccg atgcctcgat cgccgcggcg gcccggcggc
      361 tggagtccga acgcatcaag cggatgccgg tggtggacgt gcagcgtcgc ctcgtcggca
      421 tcgtgtcgcg ccgggacctg ctgtggatcc acaccaggac ggacgccgac gtccgttccg
      481 agatcgtcga ccacgtcctg ctgcgcacgc tctggatcga cccggccgcg gtcgaggtgg
      541 atgtcgtcga cggagttgtg tcgctggcgg gccgcctcga gagccgcagc ctggccggcc
      601 tggtggccag cctcgtgtcc aaggtcgccg gcgtcgtcga ggtgatcgac cggttggcct
      661 gggatcagga cgactcacgt gtggtccgtg ccgccggcta cccgttcggc acgcccgagc
      721 gcctcatgcg gccgtccaca aactgaccgg cagggcccgc gaaagggtgc ggcggcctct
      781 tgccgccgca ccctcgttgg cccggctcag gcggctcgat cggacgcgga ccgtgggccg
      841 cgatacggcg agcggatgcc ggccctgtgc aggatctcgg cgacctcttc gtaggtcgtc
      901 ggcggatact cccggtacag gcggccgatg ctgggcaccc acggctgacg gtcgacacat
      961 acggtctcgt cgacctcgtc gtccaggctc gccatggcgt cggcctcagc taccggaacg
     1021 gcgagcacga cacgttgcgc gccgcgggct cggaccgtgc gtaccgcggc gagcgccgtg
     1081 gcaccggtgg cgacgccgtc gtcgacgagc agtgctgtgc gccgcgcgag catcagcgat
     1141 gcccgaccgg cccgcactgc acgcgcgcgt cgttcgacct cggctacgag tcctgcaacg
     1201 agcgcgccga acgcgccctc cgagatccag gcgctgctga gcgctgagtc atcgaacacc
     1261 gaaatgccgc cttcggccac ggcgccgagc gtgacggcgg agacgaatgg atcctgaatc
     1321 cgctcgacga caacgacgtc caacggcagg tccagcgcac gggccacctc cagcgccact
     1381 ggaacgccac cgcgggtcac tccgagcacg accgcatcgc aaccgcgcag gtggtccaag
     1441 cggttggcga ggcggcggcc ggcgtcagcc cgatccctga aagccatctg tcgtcacctc
     1501 cgtgtcgtcc ggacagctcc atcgaacgcc ggagcacccc ggcctcggca gggactttgg
     1561 tcccggaacc gtggtcccgc ggccccgatc cggtccccgg ttcccacgtg gacattcgcg
     1621 tgcgtgcgcc tcccgagggt cctgcgcggg agcggagtgc ggcggggacc tcggtcccgt
     1681 ttggcctgcc ggccggcccg ttcgccacgt ggccgtcgga ccacgccggg tcgggcacgt
     1741 cgaccctggt ggaggccgcc gtggcagacc atgctcagag atgaacatgg gctggtagac
     1801 acacggcaac tgcccgagca gggtggggcg gtccgagggc acgtccccgc gcctacatgc
     1861 gaggttcgac tcctcgccca gccccggcgc gccggcaggt ggtcccgtca cgagcgggac
     1921 cctggcctct gccggtggcc tgggtcagcg gtcgcacgct gggcgatgag agcacgaggg
     1981 gatcgccatg acacacacga agacatcgac ggtcacgatc gtcatcgacg aacacgacga
     2041 ccaacgacac acgtccgccg aagcgcggtg gcccgccggt gttgtagaac agccggatga
     2101 tcgcctggtc gcgcaggtcc atgaatgacc ggctggcgca ggcgcccagc agggtgcggg
     2161 tctgctcggc ggtgatgacc ggcaccagct tctcgggcct cttcggttgg cggacccttt
     2221 ccatcggcta gcggcggatc gcctcctcgt cgagggtgag ccacttgaag aactgctgca
     2281 ggcacttgtg cttgttcagc gcgattgacg ccgagcggat gtcgaccatc cacgcctgga
     2341 agccctcgat gtggccgcgg ccgaccagac acgggtcgtc ggccgcctcc gcggcgtcga
     2401 actcgtcgca ctcggtcgcg aggtagcggc cgagctgagc ggcggcgagc aggtagctgt
     2461 agcgggtggt ctccgggtgg ttggcggcgc gcagggtgcg gtcccagtcg cgcaggtagc
     2521 cggaccaggt gggggacaga ccggcggtga tcttacggat gtcgatggtc ggcatggtcg
     2581 tttaactccg agtcaagggg tctggcagcg gcgtgctaga cctgacatcg atgcagagct
     2641 atgaaaagag ggctcccgca agtcgctgac ctgcggaaac cctcacgctg tcgggacggc
     2701 gggattcgaa cccacgaccc cttgaccccc agctcctggc tgggggagcg gcatactcgg
     2761 caacgtatgc ccaggtcggg tgaagcgtat acctgccgag taaaggagtc gcgacacctt
     2821 gaccacctac gcgtccggcg gggtttaccg tcgacgaaga tgtcgaccag cccttggtcg
     2881 ggtggggccg cggtgatcca gtcgacgccg gtgccggtga aggtgcagga gactgagtcg
     2941 ccgttgcggg aggtggcgtg tacatcgtcc agatggtcgc ggaacgcgaa gtcgagttgc
     3001 gctgagccga gcggaaggtc ggcgaggtag gccgagcgga ccgtcacggt ccaccccgac
     3061 agggtgtagc ggtgtcccgc tggagcgcga cgccggcccg gtagacgccg acgaactcgc
     3121 tgccgtcgtg catcagcgcc accctcacat cggccggtgc cgtgcggtcg acggcgcgga
     3181 cgcgcagggt gtgggttccg agtgtcgcct gccacgggta gatccactgg acccgggtgt
     3241 cgagattcgg ttctgggcgc acgaccgccg cctgccgcgg gtcgtcgtcg acctggacct
     3301 cgagcgcgag aattgcgttg ccttgtgcgc acgccacacc ggcaacgacg acgcgcctcg
     3361 cacggacaca ggtgaacgag tctggccggt cgatgccgga gctcgtcttg aacacttacc
     3421 agcgacgagg gcgcttctca tgatcgccgc ccgcctcacc gacgccggac cacgactcca
     3481 cggaggcggt gaagaacggt tcgggcgact aggtccgctg gcttacggcg agcggtcgct
     3541 gctgaagcac ggacaccgac agcaagggct accggttcgc cgacttcatc gacctcgttc
     3601 gactggagcc ggcggcggcg gcagtcggag ccgcgggctg gccggcaaaa gcgcacccag
     3661 ggggaggaag cgtgatcgcg ggaccggagg gtaccccggc tggggcctcc gtgaggacgg
     3721 cccggctgag ctcgccgaag ttcccgccta ccgcgccgcg gtcgagcgga tcacaccgga
     3781 cgagaccgcg gcgtcggccg gtccgcgacc gacagccgga gacgacgtac ctcgcacaga
     3841 acgcagcgtc gaacgcctcg gccaacacgg cctgctgctg ggtgtcgcgg ggggcatccg
     3901 tctccgagtg tcgcggtggg aaagcgtggc ggagatcgac ccaggcgcct ctatcgtgaa
     3961 gaccgacagg gtttccggca tctgacggag cgtcatgcga ccaggcgtgt atgcgatcag
     4021 cgacctccac gtgggattcc gtgacaaccg gacgatcgtc gaagagctcc ggccgcgcca
     4081 ccccgaagat tggctgcttg tcgccggcga tgtcggcgac tacgcctctg acgtggcgtg
     4141 gacgttcgct accttgcggc ggaactttgg cactgttatc tgggcgcccg gcaaccacga
     4201 actgtggacg ttgccggacg acccggtgca actacgcggc gttgagcgat acgagcacct
     4261 ggtgagcgtg gcccggcagc tcggtgtccg tacacccgag gacccctacg cggtatggcg
     4321 aggaagcgac gggcctgtca cggtcgcgcc cctcttcctc ctctacgact acacgttccg
     4381 accagcgggc tgccctgatg ccgcttccgc gatcgcccgg gcctatgcgg ccggcgtggt
     4441 ctgcaccgac gaagtcttcc tgcacccgga tccgcacgcg acgcggcagg aatggtgcgc
     4501 ggagcggctg aggctgaccg agcaacgtct ctccaggtgc gatccgtcca tcccgacgct
     4561 gcttgtcaac cactttccgc tcgtgcggca gccgaccctg gctctccgcc atccggagtt
     4621 cgcgatctgg tgtgggaccg accgtacctc cgactggcac ctgcgtttcg gcgcgtgtgc
     4681 ggtggtgtat ggccacctcc acattccacg aagcacccgc tacgacggcg ttcccttcga
     4741 ggaggtgtcg gtgggctatc cgtacgaatg gcgacggcgt cacgggggca gccctgccgc
     4801 aaaggcgata cttcctccac cggaatagct gggtgtatac aaagtatgga agtcgcctgg
     4861 tcggtcgggt gcgcggcacg gtcgcggtgc ttctttcgcc atccgtcgga cgacacgtaa
     4921 agcgacaacc ggccaaaacc gccgacggta cggggtggcc cccgcaaaca ccgggcggcc
     4981 gacgcggcgc agaaggggtg gcccccggag gtcgacgaac ctaccgagac ccagctctag
     5041 cagccgatcg gtaggtatcg atcatgcgaa atgatcaata tctatgtggg ataggcgaca
     5101 gtcaacctgt tgagtgctgg acgagccgct gttgaccgtg cgcgatcagt ccaatacagt
     5161 caccaatcaa tcgcgtggct agtacagcca cgccgaggct tcttcgttcg ggggtgcggg
     5221 agctgtctgc tgcagtccgt ctatctgcgg gtcggtcgta ctccatgtag tcccggccaa
     5281 cgaatccact gccttgtcgt gcggtgcagc gcggcatgcg aacgcatggt gtcctcgacc
     5341 tgacaatggg ggagcaaact gtgcccagtt cagactctgg cgaggttggt gaagcatcat
     5401 cggtctggca aaggtggaac cggcggagct cgagcggtgc gtcgtttgag catccgttcg
     5461 ctttctggct gggcatcacc attactaccg tcggtgtcat cctccagctg ccgatgtact
     5521 tcatggccgg aatggagcat taccatcttg ccggcatgcc ggtcaccacc gaaatggcga
     5581 tcggcatggt gatgttgttt atcggtgtcg ggttgaccgc ttggggcctg tatccgaaac
     5641 aggtccccgg caccgcgaag atgtccaagg ttcgcgtcgg cgccctcgat gacgccccca
     5701 tccgtcccgc acacatcgcc ctcctgctcg ttctcgcggc tgcgatcacg atcgatgtca
     5761 tgaagccggt cagcttcgcc ttcctggcac cgggcgcggc aatggaatac gggctcaaga
     5821 gtcccctcaa tccgggttcc gacgcgctgc cgatcggtct ctacccactt tccggcatca
     5881 ccggcacgat gatcggctcg ttcatctggg gatatctcgg agacaggatc ggtcgcaggg
     5941 cctccattct tctggctggc gtcatattca tcgcgacctc cacctgtggc accatgccgg
     6001 aatactggat gaatttgatc acgtgcttcg ccatgggcct gggcgtcggc ggcatgctgc
     6061 cgatcacgtt cgccctcatg tccgaagcgg tgcccaagcg ccaccggggt tggatgatgg
     6121 tgctcatcgg tgccgacatc gcgggcgcct acatcatcgt gagctggctc tccgcgacgc
     6181 tggcctcgcc cgaccagttc ggctggcgaa tgctctggct tatcggcctt cccacgggac
     6241 tcatcctcct ggtcctcaac cggtggatcc ccgaatcgcc gcggttcctg ctccagcagg
     6301 gccgtgaaga ggaagcccgc gccgtcatgc gccgctacgg agccgtgatc atcgaggaca
     6361 cggagtccga gctggtggtg gagaagaacc tgcacggaaa cttccgccag ctgttcaccg
     6421 gcccgttcat cggcctgtcc gccgcccttg tcctgctcgc gctcagtatc ggcatgaccc
     6481 aatacggctt ccagcagtgg atgccctcca acctgcagaa actcggtttc tctgaggttg
     6541 cctcgagcga gcttctccgc aacgccgcac tgatcggatt cccgctcagc gtgcccatcg
     6601 cgttgctgta cgggttctgg agcagcaaga agaccgtgat catggtgacg gcactcatgg
     6661 gggcggcgct ggccgcgttc gcgacgctgg gtgacaacgt cgtcaacaat cgaaccctgc
     6721 tctacgtcct gctggttgtt ccggtctggg gtgtgagcat cctgaactcg gtcctcgccg
     6781 cgtactccgc agaggtctat ccgacggtcg tcagggcacg agggagcggc ctgtccgccg
     6841 gtgccaccaa gctcggcggc gtcctgattc tggctaccgt cgtggtcgcg atcgccgcgc
     6901 cgtctgtgcg gatcaccgcc gcgttggggg tcatccccat ggccttagcg ttgatcgttc
     6961 tgatgatcta cggtccggaa acgcgccaca aacagcttga gagcatcacg gctgaggaat
     7021 tgaatgtgag atcagcggcc gttgggtaaa tcgacgaccg cccgtcgggc agaactgttc
     7081 ggtggccttc gtggtcgctt ccgggaggct ctgctcgacg ctggaatcgc taccgttggc
     7141 gggacacttg gcatcgccgc gatcgtggcg ctcggtgtgg tgttttccaa cccgctgctg
     7201 atcgcaccgt tcgggtcgac gtgcatgatg attttcggcg ccccggaaac gccgttcgcc
     7261 cgtcctcgta atgttctcgg cggacacctg atctgcaccg cgacgggact ggccgcactt
     7321 gaatggctgg gggaccgggc ttgggtcgcg gcgatcgctg tcggcgtcgc gatgggactg
     7381 atgaagctga cccgcacatt tcatccaccc gccggcggcg atccgattgt ggtaattctt
     7441 tcgtcgccgg cctggctgtt cgtggttgtg ccggtgttgc tcggctgcgt aacgctgatc
     7501 tgcgtcgcgt tcgtctttca caaactgagt aaacgggcat cttatccatt gtggtgaacc
     7561 gcgcgcgtga cgaccaggtt tcgtcggatc gtggtagctg gtctgcactg cgcggcaatg
     7621 tccgatctgt cgcgtcgctc gcgagatagc aaatcgacca gggactttgt ccaccccgat
     7681 ggacagatca tggacatcaa tcccgcctct ttcccgatgg cggttttctc ggttatgctc
     7741 gcgtctggtc ctggggcgat cagctctgtt gggccgtgcg tagtgcaggc accttgtgtc
     7801 ggggggaagg agccgctggt gcgtaatcgc gtcgcgctga cctcccaaga tagagatcaa
     7861 actcggcccc gtcatttgtc ccgccaagcg gtaggaaatg cggaattcaa tggccgacac
     7921 ccccgccgcc gagtcgattc gacaggtccg ccagcgctca gtcggaagcc gggccaagtt
     7981 gtataccgtt gcgaaatccg gtcgcggcgc aagaccgcac gcgcgctcgg cggatcaacg
     8041 acacccaggt cccatgccgc gaagacggca cccgaaggca ccaccgggct gatcggcgat
     8101 ggctcacacg cgcacagtgc ttctaggcca cccggccagt tggcccaccg atcccgcgcc
     8161 gcgcggaggc atgggtccaa ccggcgcagg gcgcttgggt caccgaccgc gccagcgcaa
     8221 cggacgcctc gccatcagca gcccctgccg cgtggccaac cgtgtagacc gacgatccgg
     8281 ccgtgcttca gccgcctgat gcgccgacag cggaggtcaa ccacatgacg aaagcgttct
     8341 cgggcttttc tgacaagccc ttggccgccg ctgccggtga acccgcactt gacccgacgc
     8401 ggctggcgga actggccgcg acccgcggtg gcgtcctgcc ggcgacgtcg agattcctgc
     8461 cgggactggt ccggctctgc gaagcgttgg agaaggaagc cgcgctgacg ccctctgggc
     8521 gcgtctcggc gcagcgatcg ctggtgaacg cattggtgac gcaggcagat ctgcaccggc
     8581 tgcagagcgg gcgcccgcag gtgcggcgtc agcccgtcgg ccgccccttg ttcatcacgg
     8641 gcctccatcg cagcggaacc acattgctgc agtggctgct gtcccggcac ccgcaggtgc
     8701 gtgctccgcg gctctgggag ctcctcgcgc cgtctgcggc ctcagcgccc gacgagctcg
     8761 tcggcgcagc cgacggctac gtccgggact atcatcgcgc cgcgccgacc tttgcggcca
     8821 tccacccgct gtcggcgaca gaacccgagg agtgccaccg gttgctcggc aacgcgttcc
     8881 tctccgagat ctacgcgctg cgcttccata ttccgtccta tatggactgg ctggggtccc
     8941 aggaccggga gccggcgtat cagtttcatc tcgagcaact acgggccatt ctgtggcggg
     9001 ttccaggcga gcaggtcgtc ctgaaatgcc cgttccacct gtggcacggt ggcgcgctac
     9061 gacgcgtcta cccgcatgcg cgagtcgtcc ggctccatcg cgaccccgtc gaggcgatcg
     9121 cgtcagcctg cagtctgacg cgcgcggtgc gggcggccag gtccgacgcc gtggatccgc
     9181 ttgccatcgg cgatttctgg atcgaccggg cccggtccgg ggtcgcccgg ctcgccgacc
     9241 tcgggcctac cgccaacggc ggcctaccca ccttggacct gcggtaccgc gacctcatcg
     9301 ccgatccgat cgccgccgtc cgccgggtat gccgatttct gcggctacca ctgtcggcgg
     9361 agatcgaggg tcggatacag gccgcattgc gcagcggcca cctacgcaag caaagcgaac
     9421 atacgtaccg cctgcaggac ttcggactgc ggcccgcccg gctcgaagcg atgttcgccg
     9481 actatcgcgt gagcctcgat ctcgccagtc gccgagtgct atcaccctga tacgaggaga
     9541 cgccatgacg cagccggcca acccgacggt tcccgcacag cgaaacgcgg ccaacccacc
     9601 cacgaacacc gccccggacc cgctgagtct cgtccgggtc gaggtcgacg cggtcaacga
     9661 gcacgcgggc gacgacccga tcaagatcgg catcgtgtcg cccatgagtc gaccgggcga
     9721 cgcgatggcc ggcgtgctgg tctcgcgcgg cgcccggctg ggggccgaat acctccgcga
     9781 acacggcggc gtgctcggcg gccgcaacgt gcgactcatc gcctacaacg acatggccac
     9841 cgcgaccgag gacggcttcg ccaaatcggc cgttgcgcag atggcgaaac tcgccttcgt
     9901 cgacgacgtc atcgccgcgc tgggccaatg gcacctacgc acgaccgatc ccgtcgccaa
     9961 cttgtgcgag gccgtcgggt tgccaatgtt cgtcgagaac ggccacagca ccgtcacccg
    10021 gggacgccgg agcatcttcc gcacctactt ctccatcgcc gaccgcgcac cgctgatgat
    10081 ggactgcctc aaggggaccg gcgcacgccg tgtcgcgatc ctcgccgcgg acaccgtgtt
    10141 cgggcagacc atggccaaca cgctccagca agaaggtgag gcacgcggcc tggagttcct
    10201 gcgcatcgac ttcgagcagg aggtcgtcgt cgactggcgt gacgacctgc ggcggatcaa
    10261 ggaatggcag cccgacgtct tcatcaatgg cggactcaac gtcatcgccg gaggcggccc
    10321 ggtcggcaac agctaccaca tcctccagca ggcgatcgag gtcgggttgc tcccgggcgt
    10381 cgccatgatg gtgaccttcg gatttccgat gcgttcgctc gactactggc ggatggccgg
    10441 tgagccgggc aacggcgtga tgtggccggc gacgaagttc cgcccgtcct ggcccgaaat
    10501 gacggcgatc ggccgctggt tcaccgagcg gttcactgag cggtacgggt tcgcgccgcc
    10561 agacacctgc ctgagcgcct tcaccgacgt gacgatcatc gggcaagcgc tcgaccacgc
    10621 cggcacctac tcgcgtgcgg ctctgctcga cgccttggag gaagcggagt tcgatacctg
    10681 gcgcggaccc ctacgtttcg aacgcggcca gcaccacaac ccacccgagc tggtcatcat
    10741 gcaataccag acgccgaacc agacgttcga cgaggcggcg atcatccacc cgccgtcgct
    10801 ggccgacagt aagtacctgc cgccgaacgt gaccgtcgaa tcggcttagc ggtgagccct
    10861 acccgctcgg cggcaggatc ggtcgcggac acactggtgg caggcctgcg cgcgcagggc
    10921 gtggaccgcg tcttctgtgt ggcgggagag agttacctgc cgatcctcga ccgcctctac
    10981 gacacggcgg aaatcgaggt cgtcacctgc cggcacgagg cgtcggcggc gttcgccgca
    11041 gtggctgacg ccaagctgac cggacacgcc ggtgtttgcc tggtcagccg cgcgccaggc
    11101 gcgacgaacg ccgccatcgc cgcgcactcc gccgccgagg acgccacgcc gctggtgctc
    11161 atcgtcggtg acgtctcgac cgacgaacgg ggccgcgact cattccagga gatcgactgc
    11221 gggcagttgt tcggcggatt caccaaaggt gtctggcagt tggcccaccc gccggcggcc
    11281 gcggagttcc tcggccgcgc cttccgcgtg gctgagtcag gcacacccgg cccggttgtc
    11341 ctgaccgtcc cggaagacgt cctctaccaa cgtgatccgg gccccatgtc cttgacgccg
    11401 gttctagcgg cttctgccac ggtcaggtcg gccgacctgg cggccgtcgc gtcgacggtg
    11461 cggcgcgcac gacgaccgct gctggtcgcg ggcgggctgc tcgggtccgc aaaggcccgc
    11521 gccacccttc gcgagacctc cgagcggctg ctcctgccga tcctgaccag caacaagcac
    11581 caggatctgt tcgacaatcg ccatccgcac tatgccgggc acctgcacaa caacactcag
    11641 gccggccagc gcgcgctgtt cgagcgcgcc gatgtggtgt tggcggtcgg cacccggctc
    11701 gacgcgacga ccactctggg ccaccggttc ccgtccgggt ccgtccccga ccaggcgctg
    11761 atccacgtgt atccggaccc ggcacggctg ggcgcgcggc atcgtccagc aatcgcgctc
    11821 gccgccgatc cgggcacctt cctcgggtca ctggcgcaaa ccgacccgcc gaccgacccc
    11881 gcccgggtcg attggatcga cgaactgcac gcgttcgaag tcgagaaagg tcgatggcag
    11941 cagcaccagg ccgacgacgg cgtgcctttc ggagcggtta tcacggccct cgacgacgtg
    12001 accggcggcg acatcgtggt caccgtcgac tccggcacgt tcaccagctg gctctaccgc
    12061 tacctgcggc tcaccggcaa cgcccggatg ctcggcgtga cgtccagcgc catggggttc
    12121 ggcgtgccgg cggccgtggc cgccgcgatg cggctgcggc ggcccgtggt cgcggtcgtc
    12181 ggcgacggcg gattcctcat gaccggcagc gagctggcga ccgcggtggc acacgatctg
    12241 ccgctgatcg tgttgatcgc caacaacgcc agttacggga cgatccgact acaccaggag
    12301 cgcacctacc cgggccgggt catcgccacg gacctgcgca acccggactt cgcgcgattg
    12361 gccgaggcgt acggctgtct cggcctctcc atcgccgaag aggccgacgt cgcgcccgtc
    12421 cttcgtcgcg cgatggggca tgggggcccg gtcgtcgtcg acgtgcggac aagtctgcag
    12481 tggatcaccg cctaccggcg gctggcactg acccagcccc tggtcgcggc gacctccccg
    12541 aggagtcttt gatgcactac cagaactcgt tgctcgagct catcgggaac acaccgctgg
    12601 tgcgcctcaa gagggtggct gctgggctgc cggcaaccgt cctcgccaag gtcgaatact
    12661 tgaacccggg cggctcggtc aaggaccgga tcgccgttcg aatggtcgaa gccgccgaag
    12721 cggacggccg tctgcggcca ggcggcacga tcatcgagcc gacatcgggc aacaccggtg
    12781 tcggcctggc gatcgtcgca caggagaagg ggtatcgatg cctcttcacc tgtcccgaca
    12841 aggtcgcggc cgacaagatc agggtcctgc gcgcgtacgg cgcgaccgtg gtgatctgcc
    12901 cggcgacagt tccggtcgac gatccgcgct cataccggag cgtcgcggcg cgactcgagc
    12961 gggaaaccca gggcgcggtc ctgctcgacc agtattcgca cccggagaac ccccgttcgc
    13021 actatctcgg caccggcccc gaactctggc gacagacaga cggcaggatc acccatttcg
    13081 tcgccggtat cggcacgggc ggaaccatct ccggcgccgg cgcctacctc aagaaggtgt
    13141 cgcacggacg ggtccgcatc atcggagccg accccgaggg ctcgatctac agcgatccgg
    13201 agggaccggt ccggccctac ctcctggagg gggtcggcca gccccagttg ccgcgctcgt
    13261 acgacccgac ggtgcctgac gagatcatcc gcgtgtccga tcacgaggcg atcaccatga
    13321 cccggcgcct ggcccgtgag gaagccctcc tcacgggcgg ttcatgcgga atggcggccg
    13381 tcgccgccct ccgggtcgca gagcgactca cgccggacga cctggtcgtc gtgctgctgc
    13441 ctgactccgg gcgcggctac ctggcgaaga tcttcgacga ccagtgggtg gcacggctcg
    13501 gcctcttcga cgacccggcc gacacgggtc cgcggctacg ggagcttcta ccgctttccg
    13561 tcgaacggcc gcgcgcgatc gttctgcagc cggaggtatc gctgctgcgg gcggcgaccc
    13621 tgctcgacca ctacccgggc gggacacaca tcgtggtcac cgcgggagcg cctccgctgc
    13681 ggctggccga agtcgttggc ctcgtcgccg cacacacgtt gcgggatgcg ctgaccgacc
    13741 cccgccggtc cgccatcgac ccgatctcca gcgtcgcgac cgtgcgcccg cacgtcggcg
    13801 ccggacagtc cgcctccgcg gccgcttgcc acctcgatgc ccacgacgcc gctgtcgtga
    13861 tcgagcgagg cttcgtgtgt ggcgtggtca ccggcgacga gctcgacgac ctgacccggg
    13921 ccgataccgc tcggacatca cgagaaaccg cattggagac gacgtgagca ccgtcctgga
    13981 gtacgtcgac cccttggagg gctttcgcgg gtggctcgtc tacgacgggg gcagctgtcg
    14041 catagccgcc ggtggctgcc gcgtccaaca aggcttgacg cgggacaccc tggtctcgct
    14101 ggcgagccgg atgaccctca aagagcggct gctggggatc aacgtcgacg gggccaaatg
    14161 cggcatcgac tacgaccctc gttcaccggg taaggcggca gcggtacgcc ggtttctcgc
    14221 gttcctgcgc gaagagctcg ttcaccgctt cagcatgggc tctgacatgg gcacgcggtg
    14281 ggacgaactc gagcgactgg ccgcagcgga agggatcccg tcgatcaaat acgcggtgcg
    14341 ccgggcgcag gagttcaccg acgacgagtt cttcgcgcgg ctgcgcacct tgcaggcgcc
    14401 cgtcggcgcg ctcacattgg cccagcgtcg agcaggccac gcgctggccg aagcggcagt
    14461 gggcgccgcg cgggccgccg gtcttgggcc gcgcgctacc tgcgctctcc agggcttcgg
    14521 caatctcggg cgggcggcgg cgtgcaccct ggccgaagtc ggcatgacag tggtcgcagt
    14581 gtccgacgag ttcggctgcg tggccgacca ccacggcctc gacatccctg ggatgctggc
    14641 agcgccgttc ggcacaccgg tccaagcatc ggtgcggcga ggcgaacagc tgccgtccac
    14701 ggcgttgttc aagatccccg cagacatcag catccttgcc gcgaccgaaa acgcgatctc
    14761 actgccgcag gttggggaac tgccgactcc cgtggtcgtc gtcggcgcca actgcgggct
    14821 gactcccgac gtcgaggccg cgctcgatcg cgccggtgtt ctggtcatac ccgacttcgt
    14881 cggtgggatc ggcggttccg cgtccgtcga ggccctcttc ggccccgagc atcggcctac
    14941 ggaggttcac gtactcggtg gggtcaccca gatcatgcgg cagctggtcg accatctgat
    15001 cagcgaggcg cgcaggcgcg ggacatcagc gcgttccgtc gcgctgcacc tcgcgcagac
    15061 gacgattccc gtgccggacc gccgcccgta cggacgcagc cggttcctgg catgaagctt
    15121 caacctattc gctccagctc accggaggac attccgtgtc gatgacagcc gatcggccga
    15181 cgacaagcac gtgccgccac ccgcgcgggc acatcacgga ctcccgtttt tacggcgacc
    15241 gcttcgctac gccagccagt aggcgaatct tctgcgacat ctgtcgcaag caacgttggc
    15301 tggacatcga ggccgctctc gctactgtcc aggccgagct gggcatgatc ccggcggcgg
    15361 ccgcggaggg gatcgtcgcg gcggcgaagc tcgaattcat cgacctggac gcggtcgagg
    15421 ccgagacgaa ccgcacgggg cactcgctga tcggtttgct gcgggttctt caggatgcct
    15481 gcccggaagg cagcggcgag ttcattcact tcggggccac gacgcaggac atccaggaca
    15541 ccggacaggt cctcgaaatg cgcgacgtcc tcgacgatct cgacacgacg ctgcgtgcga
    15601 tcgtccaccg ccttgtcgag ctcgccgagg aacacaccga gaccgtggcg gtgggacgaa
    15661 cccacgctcg ggcagcgctg ccgatggcat tcggactgaa gatcgcgagc tggctcgacg
    15721 aggtgctgcg acacgtcgaa cgcatcgccg acctgcgcaa ccgggcgctg gtcgctcagc
    15781 tgttcggtgg agcgggcacg atggccggat tcggcgacct aggcctggta ctcgtcgagc
    15841 ggttcgccga ccgactgggc atcggcgtgc cgacgatcgg ctggcatgtc gcgcgcgacc
    15901 gggttgtcga ctacgtgacg acgctggcga tgctggccgg cacgatgggc cggatcgccg
    15961 aagaggtgcg catcctgggc cggcccgagt tcggtgaggt ctccgaggcg tggcagtacg
    16021 ggaaggtcgg ctcgagcacg atgccgcaca aacgcaaccc ggaacgctgc gagcagacgg
    16081 tggtcatggc gaaactggcg gcaggtcagg cggccgtcgc ctacggcgcc atggtcggtg
    16141 accacgaacg cgactcgcgt gccctgcgcg tcgagtgggc gtgtgtgccc gacgtctcgc
    16201 actattgcct ggctgcctgc gagatcggcc gcgagattct cgagggtctg accgtgcatc
    16261 cggagcgact gtcgctcaac gtgcgggagg tcgccgacca gatcgcctcc gagcgcctga
    16321 tgcttgcgct gggcgagcac ctcggcaagc agactgccca cgagcgggtg tacgagatca
    16381 gccagcgggc gttcgaggtc gacagcacga tccgcgaggt gttcagagag accgaggacc
    16441 tgcgcgacat gttggacgac gccacgctcg acgccatctt caatccgtcc ggctatctgg
    16501 gcgcctccac ggcgttgacg ctgcgcgccg tggccgaggg ccgaaagtgg ttgagcaatc
    16561 gctagcgcga tgcttcggtc agccgcggcc gagcagggca ccaccgttga tctggatgac
    16621 ctgcccggtc acgaactccg acccgtggcc ggcaaggtat cgcacgacgc cggcgacgtc
    16681 ggtcggtgtc ccaccgcgac cgatcagact ctgccgcgaa cgggcttgat gaaactcggg
    16741 cgtcatccgc tcccggtaga actcggtgtc gccgatatag ccgggcgcga ccacgttcac
    16801 cgtgatgccg tcggggccta gctgggtggc gagctccgcc gaccacgggt gcagcgctgc
    16861 cttcgcggcg ccgtacgaag cgttgccgcg gaaggcggcg atcgacgtga tcgtgatgat
    16921 ccgtccgcca ccaccccgac gcaggtgtgg cagcaaagcg tgcgtaagga gaaccgttgg
    16981 aagaacgttc gaccgatagt tggtgacata ctgctcgctg agctgcgtga gatcatcggc
    17041 gccgtggggt gcgaagttcc cgccggcgtt gttgacgagg acgtcgacga cgccgtgggc
    17101 ggtcgcggcc tcggctgcgg cgtattccac ggctttcggg tccgtcaggt cggccaccac
    17161 cggacgcact cgtggttcac cgatccgctc gttgatggcc tcggcggcgg cggtgagcac
    17221 ctgggagcgt cggccgatga tgaccacatc gtcgtcgtca gccaaggcgt ccgcgatggc
    17281 ataaccgatg ccggtgccac ctccggagat cacgaccagc cggcgtccca tctcataagc
    17341 agccgtcacg cttacggtcc tccgtcgttt tctcactcac cgcgtggtcc ctcatcgtat
    17401 cggaaatcca ttgataacaa acacatcgac gagcgccacc ggggcgccgg gatcggcgat
    17461 actgttcaca tgagactctc cgcgcgggtc gactacgcca tccgcgcggt cgtcgagctt
    17521 gccgctcgga cagatcctga cgctgccccg accggcgcgg cacttcagcc ctcggtaagg
    17581 gccagcgaac tcgccgccat tcaggacatc tcaccgaagt acctcgaggg cattctgctc
    17641 agcctccgcc aaggcggcgt cgtagcggcc aggcgcggct cggtcggcgg ctaccggctg
    17701 gcccgaccgg ccaaggacat ctcgctcgcc gacatcatcc gcatcgtcga tggtccgctg
    17761 acgaacatcc gtggcttccg gcccgagcag cttgactacg tcgggccggc agccacactg
    17821 cagatggtct ggatcgcgct gcgggcccgc gaacggcaga tcctcgaggg tgtcaccgtg
    17881 gcggagatcg tccgcaacga cctacccgag cgggtgcgat cattgacgcg cgacccgcgc
    17941 gcgtggcatt agtcagtagg atgacccggt gcagcgtcac agtccggtcg acaccacggt
    18001 cgatgcctcg ttgcggcttc cgttcgcccc ggcggattac atccagcctc tgaccgacgc
    18061 catggccggc ttcgcggcga tcgccgcgac caccgacctc gatgccccca tcgcgctcaa
    18121 caagaaatgg gcactggctg gccttgtccg ccacctcggc ggcattcacc ggtgggccgc
    18181 cgcgatcgtc gagacaggca agcgcgtcag cggcgctccg aaaccgccgc tgggcgcgga
    18241 tttagcccgg tggtaccagg agagtgccga agccctcagc tccgccatcg ccaagagccg
    18301 acccgactcg acgtgctgga acttcacgaa agacccgcgc gtcaccgcgt tctggtaccg
    18361 gcgccagctc cacgagacga tcatccacgg gcgtgacgcc gacgccgcga ccgggacgat
    18421 ccgcgcgatc ccgctcggcg tggccgcgga cggggtcgac gaggtcttca cggtcatgct
    18481 gcccaccgtt cgcagatggg gaacgaagct gccgccccgg ctcaccggtc cggttctcgt
    18541 ccacgcaaca gattccgggc atcgttggct gttgacgccc accgacgacg ttcaccccgc
    18601 cgtgaaacgc caacccggcg cgaccgtgct tgcagacgct acggtcaggg ccaccgccga
    18661 ctcactgctc atggcgctgt gggggcgtgc gaccgtcgcc gaggcggacg tcaccgtcga
    18721 cggcgacgtc gaaatggcgc gggcgttcct ggacgcccgc ctcaccccct gacgatcgtc
    18781 agtcgacgtc cacaccacgt atccatagct cgccgctgga cagcgcgaac accgcggcct
    18841 ccggccgcgg gtcgagcgga tggcgtagcg acgagaccgg gtcgggagac acgccgttct
    18901 gccgcgccag cgtgctcaac gtcgtgcccg gtccgacctc gagaagcacc acctgcccgg
    18961 cgccggtggc ggccgccaga ccatccgcga accgcaccgg cgagcgcagg tggtgcgtcc
    19021 agtacgacgg atcgatggcc tcggcactgc tgagccaccc tccactcagg ttcgacacga
    19081 ccgggatcga cggcggtcgc gtgcggatac tgcgggccag tcggtcgaac tcgtcgagca
    19141 cgtcctcgat aagctcggag tgcgccgcgg ccccaaaacg cagccgccgc acggttacct
    19201 ctcgttgggc gagatccagc tccagcgccc ggaccgcttc gacgtggcca gacactacgc
    19261 attgggtcgg tgagttgatg gcggccaccg agactcccgg ccgcatcagg ggttcgagcc
    19321 ccgcgtgccc caactggacg atgagcatct caccacttgg taagccgtcc atgagctgcg
    19381 cgcgcaacgc gaccagccgc acggcatcac cgagctcgag aaccccggcg agcgtggctg
    19441 cgacgtactc gccgagggaa tggccgatca acaacgatgg ccgcagcccg cgcgccaacc
    19501 acacctgggc caacgcgtac gatgtcgcga acaacgagcc gaggcctagc ggtggccgtt
    19561 ccatcgcgct cagcgccacg tcagggtcga ggcacgcgtg gacatcgagg tccaacgcgt
    19621 ctcggaagcg gcgggcacag tcgtcgaagt ggccacggaa caccggctcg cgttcgtaca
    19681 gttgggtggc catgccggca tgctgtgcac cgccgccggg gaacatgaag ccgatccggt
    19741 cgggcgccgg ccgcggcgcc tccgcggtgc gcacgaaccg ggagggctgc ttgcgcaacg
    19801 tcgtaaccgc gtcgtcgacg gtctggcaga gcaccacccg tcgatgccgc tggctgtctg
    19861 ccggccgccg caggtcggcg aacgaggcat tgggcttccg cagccgttcg tacgcctccg
    19921 tggtggcacg ctccagctct tcagcgtcat cacccgccag gcgcagcacg tgccagctgt
    19981 cggctgccat tcgcccgaac ctacttcatg tccgcgggtt ggtttcccac gctggtcacg
    20041 agggcgtcaa cgtagcggcg cagcaaccgc tcgtcggggc cgccggcttc gacccgctcg
    20101 aagcccttgt ccacctcggc cgacggcgcg ggcaaatctg tccgcgagcc ggttgccagg
    20161 atgcccttca tcagctcgag ctggtccggg aagcgcgcgg cgatgtggtc catgaattcc
    20221 gcacgtggta gcaccggcaa tcccgcccgc tccgccagca acgcgatgac ctcgttcacg
    20281 cgcacccggg tcggtgggtc gatcgtgaac aaccccccat cgctgcggcg cgacgcgctg
    20341 gccaccagtg cccgcgcacc caggtccgcc ggcacccact cttcttcgaa ccgcaggtcg
    20401 gccgctacac ccatggccag gaatcggcgc agcagcccca tcaccgcatc tcggtcgttg
    20461 ctcaggccgg tccgggagtc gccggcgatc cgcggaagcc ggaacaccga cgccggcgca
    20521 ccacggtcgc gtgcggcaac gaccaaccgc tccgcggccc attttgacgc cgcgtagccg
    20581 ggcagggagg ggtcgcggtg ctcgccgagg cgggccgaga ccgtcgacac cagcaacagc
    20641 tccttgagtt ggccggtggt cgccagctcg atgatccggc gggtgccgtc gacgttggcc
    20701 ccttcgagcc cttcgtacgg gaacagaatg tcaacgtgtg cgcctgagtg gacgatgacg
    20761 tccagttgcg cggccagccg cgcgaactcg tcctcgctca gacccagccg ctgcctggtg
    20821 aggtccccct cccgaacgcg gacccgttcg gccaggtcgt cccggtggcg accgaaccgg
    20881 gcgaggttgg caatgacacg gtcggcggcg cgctgacccc gcaccggccg cacgaggcag
    20941 gtcactgtgc cgtcggtgcc ggacaggagc tcgtcgagca ggaaggcgcc gaagtagccg
    21001 gtcgcaccgg tgagcaggat gtgctggaac cgggtcggcg cccggggcgg caacgcggcg
    21061 ggggatgccg tctcgcgcac ggcggcaacg gctttcgacg tggtcgtgcc ggccgattcg
    21121 tccaacgctg ccgcgagatc acgaatcgta ggtttcgtat agagcaacgt cagcgcgaca
    21181 tcgcgaccgg ttacctcgcg gagggcgagg acggtgcggg cggcttggag ggatgtgccg
    21241 ccgagggcga agaagttgtc gtcgacgctg atgttgggca ggccgagggt ttcggtgaag
    21301 gtgtcggtga tggtttgttc ggtgggggtt cgtggggtga tgggggtgcg ggtggtggtg
    21361 tgttgttcgg ggtggggtag ggcgttgcgg tcgattttgc cgatggtggt gagggggagt
    21421 ttggggaggg tgacgaagat gttggggatc atgtagcggg ggaggtgttc ggcgagatgg
    21481 gtgcgtaggt cggtggtgtt gatggtgccg ttggtgggga cgatgtagcc gacgagttgt
    21541 ttgtttccgg gggtgtcttc gcggacggtg acggcggctg cggtgatgtg ggggtgggtg
    21601 gtgagggtgg attcgatttc ttcgagttcg atgcgcaggc cgttgagttt gatttgggtg
    21661 tcgatgcggc cgaggaactc gatggtgccg gtttcgttcc agacgccgag gtcgccggtg
    21721 cggtagaggc gttggttggg gttcagtggg tcggggatga atttttcggc ggtgagttcg
    21781 gggaggttga ggtagccgcg ggcgaggccg gcggcgccga cgacgacttc gccggggatg
    21841 ccgacggggc agaggttgtc ccattggtcg aagacgtagg cgacgcggcg gggcatgggg
    21901 cggccgatgg gtggttgttc ggtccaggtg cggtgttcgc attcgtggta gatgcagccg
    21961 acggcggctt cggtggggcc gtagccgttg atgaatcgtc gtggggcggt gttccagcgg
    22021 ttgacgaggt cgggtgggac ggcttcgccg ccggcgatca tgtaggtgag ttcggggtag
    22081 gggtgtgggg ggatggcgcc gaggacggcg ggtgggccgc cgaggtagtt gatgtgttcg
    22141 tcgaggagta ggtcgccgag ggcgggtggg gacaggcggg cttcttcggg gacgaacacg
    22201 agggtggcgc cggagaccag gccggtgaag atctcaccga cggcgaagtc gaagatcatg
    22261 gccatgtggt gggccatgcg ggttcctggt ccgaagtgga acaggttgcg tagccagatg
    22321 gtgaaggtgg tcagggcgtg gtgttcgatc atcacgcctt tgggtttgcc ggtggagcct
    22381 gaggtgtaga ggacgtaggc gaggctgttc tcgtcggcga gttcgggtag tggctcggcg
    22441 gcggcgtgtt cgatggtcgc ccagtctgtg tccatgcgca gtgggctcca gccgtcgggt
    22501 tctgggagtc tgggctggag tgtcgaggtg gtcaggacga ctttggcggc ggtgtcggac
    22561 aggacgaacg cgagtcgttg ttggggatgg gaggtgtcca tgacgacgaa ggcggcgccg
    22621 gtcttgagga cgccgacgag ggcgacgagc aggtcgaagc cgcgttcgag gccgacggcg
    22681 acgacgtctt ggtggccgac gccgagctgg cgcaggtggc gggcgaggat cccggcgcgg
    22741 ttgtcgagct cgccataggt cagttcggcg ccctggaatc gggccgcgac gacgtctgga
    22801 tggatcgcgg cgatctgggt gtggaccggg tcggtggtct gctcgacgtg ctggccctgc
    22861 cagtcggaca gcatccggtc gcgttcctca ccgacgacca gtggcacctg cgagacccgg
    22921 gtgctgggat cggctaccgc ggcccgcagc accagctcca gatgcgacat caggcggtgg
    22981 accctggaac ggtcgaacag atccgtcgcg aactccaccc gaaactgcaa acc
//
