LOCUS       NZ_FZOF01000075         4250 bp    DNA     linear   CON 02-JAN-2025
DEFINITION  Actinacidiphila glaucinigra strain CGMCC 4.1858, whole genome
            shotgun sequence.
ACCESSION   NZ_FZOF01000075
VERSION     NZ_FZOF01000075.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinacidiphila glaucinigra
  ORGANISM  Actinacidiphila glaucinigra
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Actinacidiphila.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900188405.1-RS_2025_01_02
            Annotation Date                   :: 01/02/2025 02:14:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,793
            CDSs (total)                      :: 8,707
            Genes (coding)                    :: 8,547
            CDSs (with protein)               :: 8,547
            Genes (RNA)                       :: 86
            rRNAs                             :: 5, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1 (5S, 16S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 160
            CDSs (without protein)            :: 160
            Pseudo Genes (ambiguous residues) :: 0 of 160
            Pseudo Genes (frameshifted)       :: 47 of 160
            Pseudo Genes (incomplete)         :: 136 of 160
            Pseudo Genes (internal stop)      :: 6 of 160
            Pseudo Genes (multiple problems)  :: 29 of 160
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:25:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 4250
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FZOF01000075.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..4250
                     /db_xref="taxon:235986"
                     /mol_type="genomic DNA"
                     /note="contig: Ga0079895_175"
                     /organism="Actinacidiphila glaucinigra"
                     /strain="CGMCC 4.1858"
                     /type_material="type strain of Streptomyces glauciniger"
     gene            complement(<1..>4250)
                     /locus_tag="CHF15_RS43705"
                     /old_locus_tag="SAMN05216252_1751"
     region          1..4250
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..4250
                     /SMILES="C=CC(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..4250
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[<0:4250](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..4250)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     CDS             complement(<1..4250)
                     /EC_number="2.3.1.-"
                     /EC_number="6.4.-.-"
                     /NRPS_PKS="Domain: PKS_AT (198-479). E-value: 3e-101.
                     Score: 330.6. Matches aSDomain:
                     nrpspksdomains_CHF15_RS43705_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (549-711). E-value: 4e-62. Score:
                     201.4. Matches aSDomain:
                     nrpspksdomains_CHF15_RS43705_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (1010-1186). E-value: 3e-58.
                     Score: 188.7. Matches aSDomain:
                     nrpspksdomains_CHF15_RS43705_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (1270-1356). E-value: 9.5e-34.
                     Score: 107.6. Matches aSDomain:
                     nrpspksdomains_CHF15_RS43705_PKS_PP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742167.1"
                     /locus_tag="CHF15_RS43705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_1751"
                     /product="type I polyketide synthase"
                     /protein_id="WP_143681806.1"
                     /sec_met_domain="mod_KS (E-value: 2e-50, bitscore: 157.9,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 5.1e-103, bitscore:
                     330.6, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.2e-64, bitscore:
                     203.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.8e-18, bitscore:
                     52.5, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 9.3e-14, bitscore:
                     37.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLWLGSIKSNMGHTQAAAGVAGIIKMVMAMRHGVLPRTLHVDEP
                     SPHVDWSEGAVSLLAEQTAWPETGRPRRAAVSSFGFSGTNAHAIIEQAPEPTPAPVEAR
                     KQAPTEVLPYVLSAKSSDALRDQAARLRSHLEDAVDVGAAVASSLATKRAAFEHRAAVV
                     ASDRDELLRGLAALEADSPAASVTRGTASTGKLAFLFTGQGSQRLGMGRELHEAYPVFA
                     QSLDAVRERLGLDALFGDDTEVLDRTEHAQPALFAIEVALFRLLESWGVRPDFLSGHSV
                     GEIAAAHVAGVLSLDDACTLVAARGRLMQALPAGGVMIALQASEDEVLPRLNERVSVAA
                     VNGPESVVIAGDEDAALAIAESFPDRKSKRLSVSHAFHSPHMDGMLDAFREVVAGLSFE
                     TPRIPVVSNLTGAVVTDEMASPDFWVRHVREAVRFLDGVRVLEAAGVTTFVELGPDGVL
                     SAMAQECATGEGAAFVPLLRKARPEAETVISALAHAHTRGVAVDWQAYFGGAGAGFADL
                     PTYAFQRQRYWLEAPAHALSGDVTSAGLGATDHPLLGAALELADADGRVFTGRLSMRSH
                     PWLADHVVFGSMLLPGTAFVELALHAGEQVGSRVLEELTLQAPLVLAESGAVQLQVVVG
                     EVDASGGRSVAVHSRPDDAESVWVRHAVGVLTDDVRPSAADLSVWPPAGAGVVEVDAAY
                     EALAEAGLVYGPLFQGLRAAWRRGDELFAEVAVPVEAQGDAEGFGVHPALLDAVLHTVA
                     LGGVLADSEGGARLPFSWNGVRLHAAGASAVRVRLAAAGDGAVSLELADTTGAPVASVE
                     SLALRAVSPEQIDAAHGTRQDSLFAVDWTALPSALASVNDPQKVVWLGSTGLVALADEG
                     QAVPEVVAVSLDAAAAVGLPDAVRAETGRVLGLVQEWLADERFAESRLVFVTRGAVAAV
                     PGEEVADLVHAPVWGLVRSAQSENPGRFGLIDLDGEIDADTVAAVLGSGEPEVAVRAGT
                     FLVPRLVRAVVAPEAEPLILDGTVLVTGASGELGALFARHLVVEYGVRDLLLVSRRGDA
                     APGAAELTAELAELGASVAWAACDVADRDALAAVLDAAPGLSAVVHTAGVLDDGVIASL
                     DQERLSAVLRPKVDAAWNLHELTQGMDLSAFVLFSSAAGVFGNAGQANYAAANAFLDAL
                     ARHRRSQGLAATSLAWGLWDGGMAGEVTRSGRSTVNALSEQEGLALFDTAAASPTAVLV
                     PLKLDLAALRSQASAGGMLPPLLSGLVRVPARRAAKAGVESVADRLAGLSVAEQEAHVL
                     ELVRSEVAAVLGHASPEGVEPDRSFRELGFDSLTAVELRNRLAAAIGLRLPATLVFDYP
                     TSAALAEYVQGELVGVATVVTAAVPVVLRDDEPIAIVGLGCRYPGGVESPEDLWRLVVE
                     GRDAISGFPEDRGW"
     aSDomain        complement(183..440)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHF15_RS43705_PKS_PP.1"
                     /evalue="9.50E-34"
                     /label="CHF15_RS43705_PKS_PP.1"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="1356"
                     /protein_start="1270"
                     /score="107.6"
                     /tool="antismash"
                     /translation="LAGLSVAEQEAHVLELVRSEVAAVLGHASPEGVEPDRSFRELGFD
                     SLTAVELRNRLAAAIGLRLPATLVFDYPTSAALAEYVQGEL"
     aSModule        complement(183..3656)
                     /complete
                     /domains="nrpspksdomains_CHF15_RS43705_PKS_AT.1"
                     /domains="nrpspksdomains_CHF15_RS43705_PKS_DH.1"
                     /domains="nrpspksdomains_CHF15_RS43705_PKS_KR.1"
                     /domains="nrpspksdomains_CHF15_RS43705_PKS_PP.1"
                     /locus_tags="CHF15_RS43705"
                     /monomer_pairings="mal -> ccmal"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(693..1220)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHF15_RS43705_PKS_KR.1"
                     /evalue="3.00E-58"
                     /label="CHF15_RS43705_PKS_KR.1"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="1186"
                     /protein_start="1010"
                     /score="188.7"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="GTVLVTGASGELGALFARHLVVEYGVRDLLLVSRRGDAAPGAAEL
                     TAELAELGASVAWAACDVADRDALAAVLDAAPGLSAVVHTAGVLDDGVIASLDQERLSA
                     VLRPKVDAAWNLHELTQGMDLSAFVLFSSAAGVFGNAGQANYAAANAFLDALARHRRSQ
                     GLAATSLAWGLWD"
     CDS_motif       complement(738..842)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0011"
                     /evalue="1.50E-21"
                     /label="PKSI-KR_m4"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="1171"
                     /protein_start="1136"
                     /score="69.0"
                     /tool="antismash"
                     /translation="AFVLFSSAAGVFGNAGQANYAAANAFLDALARHRR"
     CDS_motif       complement(870..899)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0010"
                     /evalue="3.00E-03"
                     /label="PKSI-KR_m3"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="1127"
                     /protein_start="1117"
                     /score="11.0"
                     /tool="antismash"
                     /translation="PKVDAAWNLH"
     CDS_motif       complement(1116..1217)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0009"
                     /evalue="2.80E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="1045"
                     /protein_start="1011"
                     /score="23.2"
                     /tool="antismash"
                     /translation="TVLVTGASGELGALFARHLVVEYGVRDLLLVSRR"
     CDS_motif       complement(1677..1709)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0008"
                     /evalue="1.60E+00"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="858"
                     /protein_start="847"
                     /score="2.6"
                     /tool="antismash"
                     /translation="ASVNDPQKVVW"
     aSDomain        complement(2118..2603)
                     /ASF="catalytic triad H,G,P found: False"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHF15_RS43705_PKS_DH.1"
                     /evalue="4.00E-62"
                     /label="CHF15_RS43705_PKS_DH.1"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="711"
                     /protein_start="549"
                     /score="201.4"
                     /tool="antismash"
                     /translation="HPLLGAALELADADGRVFTGRLSMRSHPWLADHVVFGSMLLPGTA
                     FVELALHAGEQVGSRVLEELTLQAPLVLAESGAVQLQVVVGEVDASGGRSVAVHSRPDD
                     AESVWVRHAVGVLTDDVRPSAADLSVWPPAGAGVVEVDAAYEALAEAGLVYGPLFQGL"
     CDS_motif       complement(2445..2519)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0007"
                     /evalue="1.60E-10"
                     /label="PKSI-DH_m2"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="602"
                     /protein_start="577"
                     /score="33.4"
                     /tool="antismash"
                     /translation="WLADHVVFGSMLLPGTAFVELALHA"
     aSDomain        complement(2814..3656)
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHF15_RS43705_PKS_AT.1"
                     /evalue="3.00E-101"
                     /label="CHF15_RS43705_PKS_AT.1"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="479"
                     /protein_start="198"
                     /score="330.6"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGSQRLGMGRELHEAYPVFAQSLDAVRERLGLDALFGDDTE
                     VLDRTEHAQPALFAIEVALFRLLESWGVRPDFLSGHSVGEIAAAHVAGVLSLDDACTLV
                     AARGRLMQALPAGGVMIALQASEDEVLPRLNERVSVAAVNGPESVVIAGDEDAALAIAE
                     SFPDRKSKRLSVSHAFHSPHMDGMLDAFREVVAGLSFETPRIPVVSNLTGAVVTDEMAS
                     PDFWVRHVREAVRFLDGVRVLEAAGVTTFVELGPDGVLSAMAQECATGEGAAFVPLLRK
                     "
     CDS_motif       complement(2949..2981)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0006"
                     /evalue="1.10E-03"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="434"
                     /protein_start="423"
                     /score="12.5"
                     /tool="antismash"
                     /translation="WVRHVREAVRF"
     CDS_motif       complement(3198..3236)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0005"
                     /evalue="2.70E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="351"
                     /protein_start="338"
                     /score="14.1"
                     /tool="antismash"
                     /translation="AAVNGPESVVIAG"
     CDS_motif       complement(3321..3443)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0004"
                     /evalue="1.50E-23"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="310"
                     /protein_start="269"
                     /score="75.1"
                     /tool="antismash"
                     /translation="GVRPDFLSGHSVGEIAAAHVAGVLSLDDACTLVAARGRLMQ"
     CDS_motif       complement(3453..3518)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0003"
                     /evalue="6.40E-05"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="266"
                     /protein_start="244"
                     /score="16.0"
                     /tool="antismash"
                     /translation="LDRTEHAQPALFAIEVALFRLL"
     CDS_motif       complement(3609..3659)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0002"
                     /evalue="1.90E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="214"
                     /protein_start="197"
                     /score="17.1"
                     /tool="antismash"
                     /translation="FLFTGQGSQRLGMGREL"
     CDS_motif       complement(4191..4235)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS43705_0001"
                     /evalue="1.50E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="CHF15_RS43705"
                     /protein_end="20"
                     /protein_start="5"
                     /score="11.2"
                     /tool="antismash"
                     /translation="GSIKSNMGHTQAAAG"
ORIGIN
        1 tcccagccgc gatcctcagg aaaaccggag atcgcatcac ggccctcaac cacaagccgc
       61 cacagatcct ccgggctctc caccccaccc ggataacggc agcccagacc cacgatcgcg
      121 atcggctcgt cgtcacgcag gacgacaggc acggctgccg tcaccacggt tgccacgccg
      181 accagttcgc cctgtacgta ctccgcgaga gcggcggagg tcggatagtc gaagacgagg
      241 gtggccggca ggcgcagccc gatcgccgca gcaaggcggt tgcgcagctc gacggcggtc
      301 agcgagtcga agcccagctc acggaacgac cggtccggct ccaccccctc cggactcgca
      361 tgtccgagca ccgccgcgac ttcggagcgc accagctcca ggacatgagc ctcctgctcg
      421 gccacggaca gtccggccag gcgatcggcc acggactcga cgccggcctt cgcggcgcgg
      481 cgggccggga cacggaccag gccgctcagc agcggcggca gcatgccgcc ggcggaagcc
      541 tgggaacgca gggccgccag gtcgagcttc agcggcacga gtacggcggt cggagaggcg
      601 gccgcggtgt cgaagagggc caggccttcc tgctcgctca gggcgttcac ggtgctgcgt
      661 ccggaacgcg tcacctcgcc tgccatgccg ccgtcccaca ggccccacgc cagcgacgtc
      721 gccgccagcc cctgcgacct gcggtgcctg gcaagcgcgt ccaggaaggc gttggcggcg
      781 gcgtagttcg cctgccccgc gttgccgaac acgcccgcag ccgacgagaa cagcacgaac
      841 gccgacaggt ccatgccctg cgtcagctcg tgcaggttcc acgccgcatc caccttcgga
      901 cgcaggaccg ccgacaaacg ctcctggtcc agggacgcga tgacgccgtc gtccaggaca
      961 cctgctgtgt gcaccaccgc cgacagcccc ggagccgcgt cgagcacagc ggccagcgca
     1021 tcccgatcgg ccacatcgca cgccgcccac gccaccgacg cacccagctc agccagctcc
     1081 gccgtcagct ccgcagcacc cggcgcggca tcaccccgcc ggctcaccaa cagcagatcc
     1141 cgcaccccgt actcgacgac aaggtgccgc gcgaacaacg cgcccagttc accactggca
     1201 cccgtcacca gcaccgtgcc gtccaaaatc agcggctccg cctccggcgc caccaccgca
     1261 cggaccagac gcggcaccag gaacgtcccc gccctgaccg cgacctccgg ctcacccgaa
     1321 cccaacaccg ccgcgacggt gtccgcgtcg atctcaccgt cgaggtcgat cagaccgaag
     1381 cggcccgggt tctccgactg cgccgaccgc accagacccc acaccggggc atgcaccaga
     1441 tccgcaacct cctcgcccgg cacagcagcc accgcacccc gcgtcacgaa caccagacgc
     1501 gactcggcaa agcgctcgtc ggccagccac tcctgcacca gacccagtac ccgaccggtc
     1561 tccgcacgca cggcgtcagg cagacccacg gctgcggcgg cgtccaagga caccgccacg
     1621 acctccggca cggcctggcc ctcgtcggca agggcgacga ggcccgtgct tccgagccag
     1681 accaccttct gcggatcgtt caccgacgcc agcgcggagg gcagcgccgt ccagtcgacc
     1741 gcgaagaggg agtcctgccg ggtgccgtgt gccgcgtcga tctgctcggg cgagaccgcg
     1801 cgcagtgcca gcgactccac cgacgcaacc ggcgcacccg tagtgtcggc cagctccagc
     1861 gacaccgcgc cgtccccggc cgccgccaac cgtacccgaa ccgccgacgc accagcggca
     1921 tgcaacctca caccgttcca cgagaacggc agccgcgcac caccctccga gtccgcaagc
     1981 acgccaccca gggccaccgt gtgcagcacg gcgtccaaca gcgccggatg cacaccgaaa
     2041 ccctcggcat ccccctgcgc ctccaccggc acggccacct cggcaaacag ctcatcaccg
     2101 cggcgccacg ccgcccgcaa cccctggaac agcggaccgt agacgagacc cgcctcagcc
     2161 aacgcctcgt acgccgcatc gacctcgacg acgcccgcgc cggcaggcgg ccacacggac
     2221 aagtcagccg cactcgggcg tacgtcgtcc gtcagcacac ccaccgcatg acgcacccac
     2281 accgattccg cgtcatccgg ccgtgaatgc accgccaccg aacgtccgcc ggatgcgtca
     2341 acttccccga ccaccacctg cagctgaacg gcaccggact ccgccagcac caagggcgcc
     2401 tgaagcgtca actcctccag aacccggcta ccaacctgct cgcccgcgtg aagagccagc
     2461 tccacgaacg ccgtacccgg cagcagcatc gagccgaaga ccacgtgatc cgccaaccac
     2521 ggatgcgaac gcatcgacaa ccgcccagtg aacacacgcc catcagcgtc cgcgagctca
     2581 agggccgcac caagcagcgg atgatcggtc gcgccgaggc cggcggacgt cacgtccccg
     2641 ctcagggcgt gcgcgggcgc ctccagccag tagcgctgcc gctggaaggc ataagtgggc
     2701 aggtcggcga accctgcgcc ggccccgccg aagtaggcct gccagtcgac cgcgacgccc
     2761 cgggtgtggg cgtgggccag ggcactgatg acggtctcgg cctccggtcg ggccttgcgc
     2821 aacaagggaa cgaaggcggc accttcgccg gtcgcacact cctgcgccat cgccgacagc
     2881 acgccgtccg ggccgagttc cacgaacgtg gtgacaccgg cggcctccag gacgcggacg
     2941 ccgtccagga atcgcacggc ttcgcggacg tgacgcaccc agaagtcagg cgaggccatc
     3001 tcgtcggtga ccacggcacc ggtcaggttg gacacgaccg gtatgcgcgg ggtctcgaac
     3061 gacagccccg caaccacctc acggaaggcg tcgagcatgc cgtccatgtg cggcgaatgg
     3121 aacgcatgac tgaccgacag ccgcttcgac ttgcgatccg ggaaggactc cgcgatcgcg
     3181 agcgcggcat cctcgtcgcc cgcgatgacg accgactccg gaccgttcac cgccgcgacg
     3241 ctcacccgct cgttcagccg cggcaggacc tcgtcctccg aggcctgcag cgcgatcatc
     3301 accccaccgg ccggcagcgc ctgcatcagc cgaccacgtg ccgcgaccag cgtgcacgcg
     3361 tcgtccagcg acaacacccc tgccacatga gcggccgcga tctcaccgac ggagtggccg
     3421 gacaggaagt ccggacgcac accccacgac tccagcagcc ggaacagcgc cacctcgatc
     3481 gcgaacagcg ccggctgggc gtgctcggtc cggtccagca cctcagtgtc atcgccgaac
     3541 agcgcatcca gcccgagtcg ctcacggacc gcgtccaacg actgagcgaa caccggatac
     3601 gcctcgtgca gttctcggcc catgcccagc cgctgactcc cctgcccggt gaagaggaag
     3661 gcgagctttc cggtgctcgc ggtgccccgt gtcaccgatg ccgccgggct gtcggcctcg
     3721 agtgcggcca ggccgcgcag gagttcatcc cggtccgagg ccacgaccgc cgctcggtgc
     3781 tcgaaagcgg cacgcttggt ggccagggag gacgcgacgg cggcaccgac atcgacggcg
     3841 tcttcgaggt gggagcggag ccgggccgcc tggtcgcgca gcgcgtccga ggacttcgcc
     3901 gacaggacgt acggcaggac ttccgtcggt gcctgcttcc gtgcttcgac cggtgcgggt
     3961 gtgggttcgg gggcctgttc gatgatggcg tgtgcgttgg tgccgctgaa gccgaacgac
     4021 gacacggcgg cgcgacgcgg gcggccggtc tccggccagg ccgtctgctc ggcaagcagc
     4081 gagaccgcgc cctccgacca gtccacgtgc ggggacggct cgtcgacgtg cagtgtcctg
     4141 ggcagcacgc cgtggcgcat cgccatgacc atcttgatga tgcccgcgac accagccgcc
     4201 gcctgggtgt ggcccatgtt cgacttgatc gaacccagcc acagcggctg
//
