LOCUS       NZ_FZOF01000020        18740 bp    DNA     linear   CON 02-JAN-2025
DEFINITION  Actinacidiphila glaucinigra strain CGMCC 4.1858, whole genome
            shotgun sequence.
ACCESSION   NZ_FZOF01000020
VERSION     NZ_FZOF01000020.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinacidiphila glaucinigra
  ORGANISM  Actinacidiphila glaucinigra
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Actinacidiphila.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900188405.1-RS_2025_01_02
            Annotation Date                   :: 01/02/2025 02:14:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,793
            CDSs (total)                      :: 8,707
            Genes (coding)                    :: 8,547
            CDSs (with protein)               :: 8,547
            Genes (RNA)                       :: 86
            rRNAs                             :: 5, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1 (5S, 16S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 160
            CDSs (without protein)            :: 160
            Pseudo Genes (ambiguous residues) :: 0 of 160
            Pseudo Genes (frameshifted)       :: 47 of 160
            Pseudo Genes (incomplete)         :: 136 of 160
            Pseudo Genes (internal stop)      :: 6 of 160
            Pseudo Genes (multiple problems)  :: 29 of 160
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:25:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 154101
            Orig. end                         :: 172841
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FZOF01000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..18740
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..18740
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..18740
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:16741](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16741
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(862..1851)
                     /gene="galE"
                     /locus_tag="CHF15_RS30460"
                     /old_locus_tag="SAMN05216252_120142"
     CDS             complement(862..1851)
                     /EC_number="5.1.3.2"
                     /GO_function="GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-207). E-value: 1.3e-09.
                     Score: 29.5. Matches aSDomain:
                     nrpspksdomains_CHF15_RS30460_NAD_binding_4.1"
                     /codon_start=1
                     /gene="galE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152793.1"
                     /locus_tag="CHF15_RS30460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120142"
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="WP_089227115.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.6e-17, bitscore:
                     56.8, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 4.4e-12,
                     bitscore: 39.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWLITGGAGFIGSHVVRAMSRAGERVVVLDDGSSGVPARVPADV
                     PVVTGSVLDRAVLDRAIAEQGVTGVVHLAARKQVGESVEQPLRYYRENLGGLGTLLEAV
                     ADAGVGRFVFSSSAAVYGLPDVPLVTESTPCLPLSPYGETKLAGEWLVRAAGRAHGIST
                     ACLRYFNVAGAAEPRLADTGVFNIVPMVFDKLTRGEAPQIFGDDYPTPDGTCVRDYIHV
                     EDLADAHLAAARWVGERDGGGADLTVNIGRGEGVSVRELIDIVLEVTGRKDVEPVIMPR
                     RAGDPASVVASSELIRRELGWAAGRGVREMVESAWQGWCLHHPEARGA"
     aSDomain        complement(1231..1839)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CHF15_RS30460_NAD_binding_4.1"
                     /evalue="1.30E-09"
                     /label="CHF15_RS30460_NAD_binding_4.1"
                     /locus_tag="CHF15_RS30460"
                     /protein_end="207"
                     /protein_start="4"
                     /score="29.5"
                     /tool="antismash"
                     /translation="ITGGAGFIGSHVVRAMSRAGERVVVLDDGSSGVPARVPADVPVVT
                     GSVLDRAVLDRAIAEQGVTGVVHLAARKQVGESVEQPLRYYRENLGGLGTLLEAVADAG
                     VGRFVFSSSAAVYGLPDVPLVTESTPCLPLSPYGETKLAGEWLVRAAGRAHGISTACLR
                     YFNVAGAAEPRLADTGVFNIVPMVFDKLTRGEAPQIFGDD"
     CDS_motif       complement(1762..1848)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CHF15_RS30460_0001"
                     /evalue="3.90E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="CHF15_RS30460"
                     /protein_end="30"
                     /protein_start="1"
                     /score="19.5"
                     /tool="antismash"
                     /translation="TWLITGGAGFIGSHVVRAMSRAGERVVVL"
     misc_feature    complement(2223..2237)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            2397..4166
                     /locus_tag="CHF15_RS30470"
                     /old_locus_tag="SAMN05216252_120143"
     CDS             2397..4166
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996269.1"
                     /locus_tag="CHF15_RS30470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120143"
                     /product="DUF5941 domain-containing protein"
                     /protein_id="WP_089227116.1"
                     /transl_table=11
                     /translation="MSTAILAGPPVAMSPIEGDLRNLGFEVVTAEDAASLATYLQAVPA
                     AERVAVVDPRLVGHVHALRLGLTDPRFDASALPGAVSVRPTARAALVRAVAETGEEGEG
                     ETLADRLAGRMEKDGVPVHRPELGVLVATVPADATGRAGAAAAVAAVDDEAVRLRSAVK
                     SRDGFFTTFFISPYSRYIARWCARRGLTPNQVTTASLLVAVIAAGCAATGTRPGFVAAG
                     ALLLASFVLDCTDGQLARYSLQYSTLGAWLDATFDRAKEYAYYAGLALGAARGGDDVWA
                     LALGAMVLQTCRHVVDFAFAETDQDARAGAAVLSRTLDRVGWTVWLRRMIVLPIGERWA
                     LIAVLTAVTTPRITLTVLIVASGLAACYTTVGRVLRSVRRRTPSGDAAARALADLADSG
                     PLAEGLTRLFRGRGVPAAALLGAAVMIATSLLAPAGSPWPVAAACCYAVTSALAVSGPL
                     KGALDWIVPPVFRAAEYTTILVLAAVSDVNGALPAAFGLVAAVAYHHYDTVYRIRGGTG
                     APPRRLVRATGGHEGRALLVTAAAAALAHNTGFTVALTVLAVALAVVVLTESIGFWVSS
                     QAPAVHDETGGPA"
     gene            4163..4912
                     /locus_tag="CHF15_RS30475"
                     /old_locus_tag="SAMN05216252_120144"
     CDS             4163..4912
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955403.1"
                     /locus_tag="CHF15_RS30475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120144"
                     /product="sugar phosphate nucleotidyltransferase"
                     /protein_id="WP_089227117.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 2e-11, bitscore:
                     37.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVDPAGEGTTTVLDLTLGN
                     FAEVGLTEAAIVVGYRKEAVYERQAALEAKYGVKLHLVENDKAEEWNNAYSLWCARDVI
                     KEGVILANGDTVHPVSVEKTLLAARGDGQRIILALDTVKQLADEEMKVITADGKGVQRI
                     TKLMDPASATGEYIGVTLIEAEAGADLADALKATFERDPQLYYEDGYQELVNRGFQVDV
                     APIGEVSWVEIDNHDDLNRAREIACRY"
     gene            4900..5961
                     /locus_tag="CHF15_RS30480"
                     /old_locus_tag="SAMN05216252_120145"
     CDS             4900..5961
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308910.1"
                     /locus_tag="CHF15_RS30480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120145"
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_089227118.1"
                     /sec_met_domain="Fe-ADH (E-value: 3.4e-22, bitscore: 72.0,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTRLIPSPVVVDIRAGALDDLASVLADQRISSSGRLAIAISG
                     GSGAVLRERLAPALPGADWYEVAGGTIDGAVKLADAMRGSRYDAVVGLGGGKIIDAAKY
                     AAARVGLPLVAVATNLSHDGICSPVSTLDNDNGRGSYGVPTPIGLVIDLDVIREAPVRY
                     VRSGIGDALSNISAIADWELSHRETGEPIDGLAAAMARTAGESVLRHPGGTGEDEFLTV
                     LSEALVLTGIAMSISGDSRPASGACHEISHAIDLLYPKRAAAHGEQVGIAAAFAMFLRG
                     AEEEAGLFAEVLHRHGLPTTPGEIGFTEAEFVTAVEYAPQTRPGRYTILEHLELSTDQI
                     RDAYADYAKTIGS"
     gene            5939..6724
                     /locus_tag="CHF15_RS30485"
                     /old_locus_tag="SAMN05216252_120146"
     CDS             5939..6724
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962488.1"
                     /locus_tag="CHF15_RS30485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120146"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_089227119.1"
                     /transl_table=11
                     /translation="MPKPSVAELRPVVHPSGLKDRRSGEHWAGRIYMREISLRWTRHLV
                     NSRVTPNQLTYLMIVAGIAAGAALLVPGLAGAVAGALLIQLYLLLDCVDGEVARWRKQT
                     SITGVYLDRVGHYLSEAALLVGFGLRAADLFHRDGATTQWGWAFLGTLAALGAILIKAE
                     TDLVDVARSRSGLPAVQDEASVPRSSGLAVARKAAAALKFHRLVGGVEASLLILAAGVA
                     DFVHGDLLFTRIVVCLLAAIAVLQTLLHLVSILASSRLR"
     gene            6778..7623
                     /locus_tag="CHF15_RS30490"
                     /old_locus_tag="SAMN05216252_120147"
     CDS             6778..7623
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983096.1"
                     /locus_tag="CHF15_RS30490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120147"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_179280038.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.3e-14,
                     bitscore: 47.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNRPEELRDLLDSVAKQRGSAIEIAVVGNGSPLPELPPGVRTVE
                     LPENLGIPGGRNVGIEAFGPDGGEVDVLLFLDDDGLLPNEDTAELVREAFAADPALGIV
                     SFRIADPESGSTQRRHVPRLRASDPLRSSRVTTFLGGANAVRTEVFREVGGLPGEFFYA
                     HEETDLAWRALDAGWMIDYRADMVLFHPLTAPSRHAVYHRMVARNRVWLARRNLPWTLV
                     PVYLGVWMLLTLLRRPSGPALRAWFGGFKEGWTAPSGTRRPMRWRTVWRLTRLGRPPII
                     "
     misc_feature    7684..7702
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            7696..8619
                     /locus_tag="CHF15_RS30495"
                     /old_locus_tag="SAMN05216252_120148"
     CDS             7696..8619
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964854.1"
                     /locus_tag="CHF15_RS30495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120148"
                     /product="ABC transporter permease"
                     /protein_id="WP_089227120.1"
                     /transl_table=11
                     /translation="MSETTHDGAVAVGPVPPAGGGLTPSQLAAKYGLSVSGARPGLAEY
                     VRQLWSRRHFISAFARARVSAQYTQARLGQLWQVLTPLLNAAVYYFIFGLLLGTDRGVD
                     NFIAFLVTGVFIFTFTQSSVLAGVRAVSGNLGLIRALHFPRASLPIAFTLVQLQQLLMS
                     MFVLLAIVLMTGEVPGPSWLLVAPALVLQCVFNAGLALVMARLGSKMTDLAQLMPFILR
                     TWMYASGVMYSISHFAAHAPAVVKIALDVNPAAVYIDLMRFALIESFTSEQLPPHVWAL
                     ALGWAVVMGVGGFVYFWKAEERYGRG"
     gene            8612..9406
                     /locus_tag="CHF15_RS30500"
                     /old_locus_tag="SAMN05216252_120149"
     CDS             8612..9406
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558133.1"
                     /locus_tag="CHF15_RS30500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120149"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_089227121.1"
                     /transl_table=11
                     /translation="MAEHNDTAPGGERVPTVIVDDLHIVYRVHGAGSGKGSAVGALSRL
                     VTRKGGNPNVRKVHAVRGVSFTAYRGEAIGLIGSNGSGKSTMLRAIAGLLPAESGRVFT
                     EGQPSLLGVNAALMNDLTGERNVILGGLAMGMSQDEVRERYEQIVEFSGINEKGDFISL
                     PMRTYSSGMAARLRFSIAAAKSHDVLMIDEALATGDRSFQKRSEARIRELRKEAGTVFL
                     VSHNNKSIRDTCDRVLWLEKGELRMDGPTAVVLKAYEEFTAK"
     gene            10001..10930
                     /gene="hpnC"
                     /locus_tag="CHF15_RS30510"
                     /old_locus_tag="SAMN05216252_120150"
     CDS             10001..10930
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558134.1"
                     /locus_tag="CHF15_RS30510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120150"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_378355778.1"
                     /sec_met_domain="phytoene_synt (E-value: 5.6e-42, bitscore:
                     137.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 4.9e-43,
                     bitscore: 140.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGFKPETRAITVPDPHSRAVLDKAARENFPVAPFFVPRSWRADL
                     MAVYGFARLVDDIGDGDLADGGRTDAVRLGLPAEAAEDRLAMLDAFEADLRRVFGDGPD
                     DVRHPLLRALRPTVRRHGLTPAPFLGLVEANRQDQVVRRYATYEDLLAYCELSANPVGR
                     LVLGITGTATPERIRRSDAICTALQIIEHLQDVAEDLGRDRIYLPAEDMKRFGVTETDL
                     TAATAGAQVRALVAYEAERARDLLNEGTPLVGSVHGRLRLLLAGFAGGGRAALRAIADA
                     GYDVLPGPPKAGRLSLLREVGSTLRREG"
     gene            10957..11865
                     /gene="hpnD"
                     /locus_tag="CHF15_RS30515"
                     /old_locus_tag="SAMN05216252_120151"
     CDS             10957..11865
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558135.1"
                     /locus_tag="CHF15_RS30515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120151"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_089227124.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.3e-58, bitscore:
                     190.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.2e-69,
                     bitscore: 226.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGPVLAAYRYCEVVTGHEARNFAYGIRLLPTPKRQAMSALYAFS
                     RRVDDIGDGDLDLPEKQRRLDGTRDLLTRVQEGAVTEDDTDPVAVALADAGRRFPIPLG
                     GLEELIDGVQMDLRGDTYETWEDLASYCRCVAGAIGRLSLGVFGTAPGAPGRERAAEYA
                     DTLGLALQLTNILRDLREDAANGRTYLPADDLAKFGCSAGFLTDTPPPGSDFAGLIEYE
                     VKRARALFAEGYRLLPMLDRRSGACVSAMAGIYRRLLERIAADPEAVLRGRVSLPGHQK
                     AYVAARGLAGLDARRAARRRV"
     gene            12052..13497
                     /gene="hpnE"
                     /locus_tag="CHF15_RS30520"
                     /old_locus_tag="SAMN05216252_120152"
     CDS             12052..13497
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558136.1"
                     /locus_tag="CHF15_RS30520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120152"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_089227125.1"
                     /transl_table=11
                     /translation="MAERTAVVIGGGLAGTTAALALADAGLRVTLLEARPRLGGLAFSF
                     QRGDLTVDNGQHVFLRCCVAYLRFLERIDAADLVTLQDRLDVPVLDVATPRPRLGRLRR
                     AGLPVPLHLAASLATYPHLSLAERASVGRAALALRSLDPADPALDDVDFGTWLREHGQS
                     ARTIEALWDLVGVATLNATADEASLGLAAKVFKTGLLSAPGAADIGWAARPLGELHDDR
                     ARTALDKAGVRTLLRTRATSLTRTDASEPVRSGDGGPGGGGPVWEVEAETGPGRAERFT
                     ADTVVLAVPQQEAHGLLPAGALADQDALLRIGTAPILNVHVVYDRQVMRQPFFAALGSP
                     VQWVFDRTEHSGLTGGGQYVALSQSAAQEEIDLPVAELRKRYLPELERLLPVAREAAVL
                     DFFVTRERTATFAPLPGVGALRPGARTRADGVWLAGAWTATGWPATMESAVRSGLQASR
                     AALTALRHPFDPRTFAIEGLEPV"
     gene            13494..14615
                     /locus_tag="CHF15_RS30525"
                     /old_locus_tag="SAMN05216252_120153"
     CDS             13494..14615
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964849.1"
                     /locus_tag="CHF15_RS30525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120153"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_179280035.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.3e-58, bitscore:
                     190.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMTSAIRGENVTAGNEQMTAGVDRATVTALLERGRELSTPVLRA
                     AVDRLAPPMDTVAAYHFGWIDAAGNPSHGDSGKAVRPALALLSAEAAGAAPEVGVPGAV
                     AVELVHNFSLLHDDLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALANEILLEQGTVE
                     AGRATRRITTATRKLIDGQAQDISFEHRERVTVEECLEMEGNKTGALLACACSIGAVLG
                     GASEADADALEEYGYHLGLSFQAIDDLLGIWGDPAATGKQTWSDLRQRKKSLPVVAALA
                     AGGSASRRLAELLAADAKAADSSERSDIESFDEEEFATRAALIEEAGGREWTSREARRQ
                     YATAIAALDKMDMPGEVRRKLVGLADFVVVREK"
     gene            14714..16741
                     /gene="shc"
                     /locus_tag="CHF15_RS30530"
                     /old_locus_tag="SAMN05216252_120154"
     CDS             14714..16741
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558138.1"
                     /locus_tag="CHF15_RS30530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120154"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_089227127.1"
                     /sec_met_domain="T2TS (E-value: 7.2e-154, bitscore: 506.5,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDGGPGGEAARGTPSARTKTSGAIPEPASGPGTGGLSGRTE
                     ELAAEAARRATGHLLARQHPDGWWKGDLETNVTMDAEDLLLRQFLGIQDETVTGAAGRW
                     IRSQQREDGAWPTFHGGPGDLSATVEAYVALRLAGDAPEEPWMAAASAFVRERGGIARC
                     RVFTRIWLALFGWWRWDDLPELPPELIYLPKWVPLNIYSFASWARQTIVPLTIVAAHRP
                     VRPAPFVLDELHTDPARPNPPVPRAPLSSWDGFFQRLDRALHAYRKVSVRPLRRAAMRS
                     AARWIIERQENDGCFGGIQPPAVYSVIALHLLGYDLDHPVLRAGLKALDEFAVWPDKDT
                     RMIEACQSPVWDTCLATIALADAGVPADDPALVKAVDWMLGEQITKSGDWAVQRPGLPS
                     GGWAFEFQNDTYPDIDDTAEVVLALIRVDHPEPERVKASVDRGVRWNVGMQSKNGAWGA
                     FDADNTSAFPNRLPFCDFGEVIDPPSADVTAHVVEMLAALGLEHAPHTRRGIDWLLAEQ
                     ERSGAWFGRWGVNYIYGTGSVVPALVAAGLPAAHPAIRRAVGWLESVQNEDGGWGEDLR
                     SYSLAEWAGRGESTASQTAWALLALLAAGEREGEAVRRGVRWLAGTQNEDGSWDEPYFT
                     GTGFPRDFSINYHLYRMVFPLTALGRYVRGEPFGGLRKGA"
     misc_feature    14760..14774
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            16741..17343
                     /locus_tag="CHF15_RS30535"
                     /old_locus_tag="SAMN05216252_120155"
     CDS             16741..17343
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330384.1"
                     /locus_tag="CHF15_RS30535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120155"
                     /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate
                     reductase"
                     /protein_id="WP_089227128.1"
                     /transl_table=11
                     /translation="MGPSGPALVIVCALRVERFALRGGDRSHAAGPVAFVRTGMGPQAA
                     ERAVTAALRDPALDGAAVLTTGFCAGLAPGMRPGDVVVADEPPDGESLAAALKAAGHTV
                     HVGRLAESDHVVRGPERAALRATGAVAVDMESAAMMRAALARGPRPVAAARVVVDTPEF
                     ELVRVGTLRTGITAFRVLRDLLPAFLDWHRSTALPWR"
     gene            17349..18377
                     /gene="hpnH"
                     /locus_tag="CHF15_RS30540"
                     /old_locus_tag="SAMN05216252_120156"
     CDS             17349..18377
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558140.1"
                     /locus_tag="CHF15_RS30540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120156"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_089227129.1"
                     /sec_met_domain="PF04055 (E-value: 4.5e-19, bitscore: 62.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.4e-10, bitscore: 33.0,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQSIRVGTYLFEQKMLRRREKFPLIVELEPLFACNLKCEG
                     CGKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYV
                     FLCTNAMLLRKKLENFTPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRG
                     FRVTTNSTFFNTDTPQTIIEVLNFLNDDLQVDEMMISPAYAYEKAPDQEHFLGVEQTRE
                     LFKKAFSGGNRKKWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYV
                     TTYKELVEDTDWSKYGRGKDPRCANCMAHCGYEPTAVLATMTSLKESIRATRETVTGNR
                     GK"
     gene            18385..>18740
                     /locus_tag="CHF15_RS30545"
                     /old_locus_tag="SAMN05216252_120157"
     CDS             18385..>18740
                     /EC_number="1.17.7.3"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity (ferredoxin) [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018534474.1"
                     /locus_tag="CHF15_RS30545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_120157"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_179280036.1"
                     /transl_table=11
                     /translation="MKAVEPVALGLPSVPARPLAERRRSRRIQVGPVAVGGDAPVSVQS
                     MTTTLTADVNATLQQIAELTASGCQIVRVACPSQDDADALAQIARKSQIPVIADIHFQP
                     KYVFAAIDAGCAAVR"
ORIGIN
        1 ccacgtcctt gggcgcggcc tccagcagga cgtcgatcgc ctcgcgcagc agtttccacg
       61 tccgcgggac gatcatcagg ccgatcagga tcgaggcgac cgggtccgcc cgctgccagc
      121 cggtgaccag gatcaccagc gccgccacga ccacggccag tgagcccagg gcgtccgcca
      181 tgacctcaag gaaggcaccc cggacgttga ggctctcgcg ctgcccgcgc atcagcagca
      241 gcagggacac cgagttcgcc accaggccga tcgcgccgaa gacgacggtg agcccgccct
      301 cgacctcggt gggtgtgatg agccggcgga ccgcctcgta gaagatgaag gcacccacgc
      361 cgaacagcag caccgcgttg gccaccgccg acaggatctc ggcgcgcgcc agcccgaagg
      421 tgcggcgctc gctcggcggg cggttggcga agtggatggc gaccagcgcc atcgccaggc
      481 ccgccgcgtc ggtggccatg tgcccggcgt cggcgagcag ggcgagcgat ccggtcagcg
      541 cgctgcccgc gacctccgcc acgaggatca gcagcgtgat gccgagcgcc atgcgcagcc
      601 gcccgcggta cgcggcggcc gccgtgcccg tgggtacgga ccccggcccg tgcgggtggc
      661 cgtggccgtg cgcgtgtcct gcgcccatcg cccgacactc ccgtccgtcg ccccccgcgc
      721 gacggcgtgc ccgcgcgcgg agaccggcga gcccagtgaa caacggtcac cgtccgtggg
      781 caactcgccg ctggtgaccg ctgtcagcgg tggtgacctg cggcgatggg ccacggctcc
      841 accgcggggg aacgatcgtg gtcaggcgcc ccgcgcctcc gggtggtgca ggcaccagcc
      901 ctgccacgcg gactcgacca tctcgcggac gccgcggccg gccgcccagc ccagttcccg
      961 gcggatcagc tcggacgagg cgaccacgct cgccgggtcg ccggcgcgcc gcggcatgat
     1021 caccggctcg acgtccttgc ggccggtgac ctccaggacg atgtcgatca gctcccggac
     1081 ggagacgccc tcgccgcgtc cgatgttcac cgtcaggtcg gcgccgccgc cgtcccgctc
     1141 gccgacccag cgggccgccg cgagatgggc gtccgccagg tcctcgacgt ggatgtagtc
     1201 gcgcacgcac gtgccgtcag gcgtcgggta gtcgtccccg aagatctgcg gggcctcgcc
     1261 cctggtcagc ttgtcgaaga ccatcgggac gatgttgaac accccggtgt cggcgagccg
     1321 gggctcggcc gcccccgcga cgttgaagta gcgcaggcag gcggtggaga tcccgtgcgc
     1381 ccgcccggcc gcgcggacga gccactcgcc ggccagcttg gtctcgccgt acgggctcag
     1441 cggcaggcag ggcgtggact cggtcaccag cggcacgtcg ggcaggccgt acacggcggc
     1501 ggaggaggag aagacgaagc ggccgacgcc ggcgtccgcc accgcctcca gcaacgtccc
     1561 gaggccgccc aggttctccc ggtagtagcg cagcggctgc tccaccgact cgccgacctg
     1621 cttcctggcg gccaggtgca ccacacccgt cacgccctgc tcggcgatcg cgcggtccag
     1681 cacggcgcgg tccaggacgg agccggtcac caccgggacg tccgcgggca ccctggcggg
     1741 tacaccggac gagccgtcgt cgagcacgac cacgcgctcg cccgcccggc tcatcgcccg
     1801 caccacgtga gatccgatga agccggcccc gccggtgatc aaccaagtca tggcgccacc
     1861 ctagtggctc ggtgcacggc cgggtgagtg cggatccggc ccccctcgga ggtcaccggg
     1921 gcggggcgag accgacaggg cacggacgct cgcagcgccg tcggcgccct gtcccggctg
     1981 gtcacccgca agggcggcaa cccggacgtc cgcagggtgc acgcggtgcg gggtggcggc
     2041 ttcgccgccc acccgcggcg aggcgatcgg tctgatcggc tccaacgact cgggcaagtc
     2101 cacatgctca gggacgagtc ccgcacgccg gcggcggccg gccgtcctgc ggtgggcgct
     2161 cccggcactc accgtgaccc ccgctccacg cggtgtaccg ggcgttgtcg atcgcccgcg
     2221 tgatcaacca tgatgatcac gcccagcggc ccatcacagg ggaaacggcc ggtgaacgga
     2281 gccttccggg aatccgatag cctctgccga cacggccccc cgcggcgcgt cgcacccgtg
     2341 cggcggcgtc cccgtcggcg ccgagcacac tcgcaagtcc agggagatga gtccttctgt
     2401 cgaccgccat cctcgccggt ccgccggtcg cgatgtcgcc gatcgagggc gacctgcgga
     2461 acctcggctt cgaggtcgtc accgcggagg acgccgcctc gctcgccacg tacctgcagg
     2521 cagtccccgc ggccgagcgc gtcgccgtgg tcgacccccg cctcgtcggg cacgtgcacg
     2581 cactgcgcct cgggctgacc gacccccgct tcgacgcctc cgccctgccc ggcgccgtct
     2641 cggtgcgccc caccgcccgc gccgccctgg tgcgggccgt cgcggagacc ggggaggagg
     2701 gcgagggcga gaccctcgcc gaccggctcg ccgggcggat ggagaaggac ggcgtgcccg
     2761 tccaccgtcc cgagctcggt gtcctggtcg cgaccgtccc ggccgacgcc acgggtcgcg
     2821 ccggcgccgc ggcggccgtc gccgccgtcg acgacgaggc ggtgcggctg cgcagcgccg
     2881 tgaagtcccg cgacggcttc ttcaccacgt tcttcatcag cccctactcc cgctacatcg
     2941 cgcgctggtg cgcccgccgc gggctcaccc cgaaccaggt gacgaccgcc tcgctgctgg
     3001 tggccgtgat cgcggccggc tgcgcggcca ccgggacccg gccgggcttc gtcgccgcgg
     3061 gcgcgctgct gctggcgtcc ttcgtcctgg actgcaccga cggccagctg gcccgctact
     3121 cgctgcagta ctccacgctc ggcgcctggc tggacgcgac cttcgaccgc gccaaggagt
     3181 acgcctacta cgcgggcctg gcgctcggcg cggcccgcgg cggcgacgac gtctgggcgc
     3241 tggcgctcgg cgccatggtg ctgcagacct gccgccatgt cgtggacttc gccttcgccg
     3301 agaccgacca ggacgcccgg gccggtgccg cggtgctctc ccgcacgctc gaccgcgtcg
     3361 gctggacggt gtggctgcgc cgcatgatcg tgctgcccat cggcgaacgc tgggcgctga
     3421 tcgcggtgct cacggcggtg accacgccgc gcatcaccct caccgtgctc atcgtcgcct
     3481 ccgggctcgc cgcctgctac accacggtcg gccgcgtgct gcgctccgtg cgccgcagga
     3541 cgccctcggg cgacgccgcc gcccgggcgc tggccgacct cgccgacagc gggccgctcg
     3601 ccgagggcct gacgcgtctc ttccggggcc gcggcgtgcc cgcggccgcg ctgctgggcg
     3661 cggcagtgat gatcgccacg tccctgctcg ccccggccgg cagtccgtgg ccggtggccg
     3721 ccgcctgctg ctacgccgtg acctcggcgc tcgccgtctc cgggccgctc aagggagccc
     3781 tcgactggat cgtgccgccg gtcttccgcg ccgccgaata caccaccatc ctggtgctgg
     3841 cggcggtctc cgacgtgaac ggagcattgc ccgcggcttt cgggctggtg gccgcggtcg
     3901 cctaccatca ctacgacacg gtgtaccgca tccgcggcgg gaccggggcg cccccgaggc
     3961 gcctggtccg cgcgaccggc ggtcacgaag gccgggcact gctggtcacc gcggcggccg
     4021 cggccctggc gcacaacacg ggtttcacgg tcgcgctgac ggttctcgcc gtcgcgctgg
     4081 cggtggtggt gctcaccgag agcatcggct tctgggtgtc ctcgcaagca cccgctgtac
     4141 acgacgaaac tggaggacct gcatgatcgg cctcgtgctg gcggccggcg ccggacggcg
     4201 actgcgcccc tacaccgaca ccctgccgaa ggccctggtg ccggtggacc cggcgggtga
     4261 gggcaccacc accgtcctcg acctcaccct gggcaacttc gccgaggtcg gcctgaccga
     4321 ggccgccatc gtcgtgggct accgcaagga ggccgtctac gagcggcagg ccgcgctgga
     4381 ggccaagtac ggcgtgaagc tccacctcgt cgagaacgac aaggccgagg agtggaacaa
     4441 cgcctactcc ctgtggtgcg cccgtgacgt catcaaggaa ggcgtcatcc tcgccaacgg
     4501 cgacaccgtg cacccggtct ccgtggagaa gaccctgctc gccgcccgcg gcgacgggca
     4561 gcgcatcatc ctcgccctcg acacggtcaa gcagctcgcc gacgaggaga tgaaggtcat
     4621 caccgcggac ggcaagggcg tccagcggat caccaagctg atggacccgg cgtccgcgac
     4681 cggtgagtac atcggcgtca ccctcatcga ggccgaggcc ggcgccgacc tggcggacgc
     4741 gctgaaggcc accttcgagc gcgacccgca gctgtactac gaggacggct accaggagct
     4801 ggtcaaccgc ggcttccagg tcgacgtcgc ccccatcggc gaggtctcct gggtcgagat
     4861 cgacaaccac gacgacctga accgggcccg ggagatcgcg tgccggtact gacgaggctc
     4921 atcccctcgc cggtcgtcgt cgacatccgt gccggagccc tggacgacct ggcgagcgtg
     4981 ctcgccgacc agcgcatctc cagctccggc aggctcgcca tcgcgataag cggcggctcc
     5041 ggggccgtac tgcgcgagcg gctcgccccg gcgctgccgg gcgcggactg gtacgaggtg
     5101 gccgggggca ccatcgacgg tgccgtgaag ctcgccgacg ccatgcgcgg cagccgctac
     5161 gacgcggtgg tcgggctcgg cggcggcaag atcatcgacg ccgccaagta cgccgccgcg
     5221 cgcgtcggcc tgccgctggt ggcggtggcg acgaacctgt cgcacgacgg catctgctcg
     5281 ccggtgtcca ccctggacaa cgacaacggc cgcggctcct acggcgtgcc gacccccatc
     5341 gggctcgtca tcgacctcga cgtgatccgc gaggcgccgg tccgctacgt gcgctccggc
     5401 atcggcgacg ccctgtccaa catctcggcg atcgccgact gggagctgtc ccaccgcgag
     5461 accggggagc cgatcgacgg actggcggcc gccatggcgc gcaccgccgg cgagtcggtg
     5521 ctccggcacc cgggcggcac gggcgaggac gagttcctga ccgtgctgtc cgaggcgctg
     5581 gtgctcaccg gcatcgcgat gtcgatcagc ggcgacagcc gccccgcctc cggggcgtgc
     5641 cacgagatca gccacgcgat cgacctgctg taccccaagc gggccgccgc ccacggcgag
     5701 caggtcggca tcgccgccgc cttcgcgatg ttcctgcgcg gcgccgagga ggaggccggc
     5761 ctcttcgcgg aggtcctgca ccgccacggg ctgcccacca cgccgggtga aatcggcttc
     5821 accgaagccg agttcgtcac ggccgtcgaa tacgctccgc agacccgccc cgggcgttac
     5881 accatcctgg agcacctgga gctctccacc gaccagatca gggacgcata cgccgactat
     5941 gccaaaacca tcggtagctg agctgcggcc ggtcgttcac ccctccgggc tgaaggaccg
     6001 tcgcagcggt gagcactggg ccgggcgcat ctacatgcgg gagatctcgc tgcgctggac
     6061 ccggcacctc gtcaacagcc gggtgacccc caaccagctc acgtacctca tgatcgtcgc
     6121 gggcatcgcg gccggcgcgg cgctgctggt gcccggcctg gccggagccg tggccggcgc
     6181 gctgctgatc cagctgtacc tgctgctgga ctgcgtcgac ggcgaagtcg cccgctggcg
     6241 caagcagacc tcgatcaccg gcgtctacct cgaccgggtg gggcactacc tgtccgaggc
     6301 ggcgctgctg gtcgggttcg ggctgcgcgc ggcggacctc ttccaccgcg acggcgccac
     6361 cacccagtgg ggctgggcgt tcctcgggac gctggccgcg ctcggcgcga tcctgatcaa
     6421 ggccgagacg gacctggtgg acgtggcccg ctcccgcagc ggcctgcccg ccgtccagga
     6481 cgaggcctcc gtgccccggt cctccggtct ggcggtggcc cgcaaggccg ccgccgcgct
     6541 gaagttccac cggctggtgg gcggtgtcga ggcctcgctg ctgatcctcg ccgccggcgt
     6601 cgcggacttc gtccacggcg acctgctctt cacccgcatc gtcgtctgcc tcctggccgc
     6661 catcgccgtg ctgcagacgc tgctgcacct ggtgtcgatc ctcgcgtcga gcaggctgag
     6721 gtgagcgccg tggggacgtc ggccggaacg atccgcctcg gcgcggtgat catcaccatg
     6781 ggcaaccgcc ccgaggagct gcgcgacctg ctggactcgg tcgccaagca gcgcggctcg
     6841 gcgatcgaga tcgccgtggt cggcaacggg tcgccgctgc ccgagctgcc ccccggcgtg
     6901 cggaccgtcg agctgcccga gaacctgggc atccccggcg gccgcaacgt cggcatcgag
     6961 gccttcggcc ccgatggcgg cgaggtcgac gtgctgctgt tcctggacga cgacgggctg
     7021 ctgccgaacg aggacaccgc ggagctggtc cgtgaggcct tcgccgcgga ccccgcgctc
     7081 ggcatcgtca gcttccggat cgccgatccg gagtccggga gcacccagcg ccgccacgtc
     7141 ccccggctgc gggcctccga ccccctgcgc tcctcgcgcg tcacaacctt cctcggcggc
     7201 gccaacgcgg tccgcacgga ggtcttccgg gaggtcggcg gcctgcccgg cgagttcttc
     7261 tacgcccacg aggagaccga cctcgcctgg cgggccctcg acgcgggctg gatgatcgac
     7321 taccgcgccg acatggtgct gttccacccg ctgaccgccc cgagtcggca cgcggtctac
     7381 caccgcatgg tggcccgcaa ccgcgtgtgg ctggcccgcc gcaacctgcc gtggaccctg
     7441 gtccccgtct acctcggcgt gtggatgctg ctgaccctgc tgcgcagacc ctcgggcccc
     7501 gcgctgaggg cgtggttcgg cggtttcaag gagggctgga cggccccgag cggcacgcgc
     7561 cggcccatgc ggtggcggac ggtgtggcgc ctcacccgac tggggcgacc cccgatcatc
     7621 tgacaagctc ggacgagagt gaccccgcgc gacgggcagg gccccaggcg cgccaagagg
     7681 acgaaagtgt caactgtgag cgagacaacg cacgacggtg cggtcgccgt gggccctgtg
     7741 cccccggcgg gcggcggcct cacgccgtcc cagctggcag ccaagtacgg cctgtccgtc
     7801 agcggcgccc ggccgggcct cgccgagtac gtacggcagc tgtggagccg ccgtcacttc
     7861 atctcggcgt tcgcccgggc ccgcgtgtcg gcgcagtaca cccaggcccg gctgggccag
     7921 ctgtggcagg tgctgacgcc gctgctcaac gcggccgtct actacttcat cttcggcctg
     7981 ctgctgggca ccgaccgcgg tgtcgacaac ttcatcgcct tcctggtcac cggcgtcttc
     8041 atcttcacct tcacccagtc ctcggtgctc gcgggggtgc gcgccgtctc gggcaacctc
     8101 gggctgatcc gcgcgctgca cttcccgcgg gcgagcctgc cgatcgcctt caccctggtg
     8161 cagctccagc agctgctgat gtcgatgttc gtgctgctgg cgatcgtgct gatgaccggc
     8221 gaagtgccgg gcccgtcctg gctgctcgtg gcgcccgcgc tcgtcctgca gtgcgtcttc
     8281 aacgccggcc tggcactggt catggcccgg ctcggcagca agatgaccga cctcgcgcag
     8341 ctgatgccgt tcatcctgcg cacctggatg tacgcatccg gtgtcatgta cagcatcagc
     8401 cacttcgcgg cgcacgcacc ggccgtggtc aagatcgccc tggacgtcaa cccggcggcc
     8461 gtctacatcg acctgatgcg cttcgccctg atcgagagct tcacctcgga gcagctgccc
     8521 ccgcacgtgt gggcgctggc gctgggctgg gccgtggtca tgggcgtcgg gggcttcgtc
     8581 tacttctgga aggccgagga gaggtacggc cgtggctgag cacaacgaca ccgccccggg
     8641 cggcgagcgc gtccccaccg tgatcgtgga cgacctgcac atcgtgtacc gggtgcacgg
     8701 cgccggctcg ggcaagggca gcgccgtcgg cgccctgtcc cggctggtca cccgcaaggg
     8761 cggcaacccg aacgtccgca aggtgcacgc cgtgcgcggc gtgagcttca ccgcctaccg
     8821 cggcgaggcg atcggcctga tcggttccaa cggctcgggc aagtcgacca tgctgcgcgc
     8881 catcgccggc ctgctgcccg ccgagagcgg cagggtcttc accgagggcc agccctcgct
     8941 gctcggcgtg aacgccgccc tgatgaacga cctgaccggc gagcggaacg tcatcctcgg
     9001 cggcctcgcc atgggcatgt cgcaggacga ggtgcgggag cgctacgagc agatcgtcga
     9061 gttctccggg atcaacgaga agggcgactt catctcgctc ccgatgcgga cctactcctc
     9121 cggcatggcg gcccgcctgc ggttctcgat cgccgcggcc aagagccacg acgtgctcat
     9181 gatcgacgag gcgctcgcca ccggcgaccg ctccttccag aagcgctcgg aggcgcggat
     9241 ccgcgagctg cgcaaggagg ccggcaccgt cttcctggtc agccacaaca acaagtcgat
     9301 ccgcgacacc tgcgaccgcg tgctctggct ggagaagggc gaactgcgca tggacggccc
     9361 gacggccgtc gtcctgaagg cgtacgagga gttcaccgcc aagtgacccc gcggaccggc
     9421 ccgcgctccc gaccgggtgc gcgggccggc gcatgcctgc ggtcggaggc gagcccgcag
     9481 ggcgcaccgg cgtgcgcccg ggcccggcgg cccggcgaac tcacccacct ccgcgcgccg
     9541 ttcggccgcg ctcccgcgcc ggtcgcgccc cccgtcccgc ggaacgccgt ccgggcccgg
     9601 tacggatacg ccaagtgagt gggcgcgcgc ccggcgcatc cgcggcgcgc ggttcgcggg
     9661 gcgaatgggg ccgatgattt tcccgggatt ttgcgagaca ccggggacgc gaacccgagg
     9721 tttgtgcgtt cctgctttcg gatcggcata ggtccgcccc ccggcgcacg ccggagcgga
     9781 tccgcgccgt aagctgtagc ggtactcaat cgccggatct cgggcgatac gtccggagag
     9841 ccggtcgggt gcggggacag ccgggagcag gaattatagg agcggcgtgt ccgaaattgg
     9901 gtgtaatggg ctatcggtgt agaacggggg atgtgacgga aatggctctg tggacccctg
     9961 gggagaaaac gcccaccgcc cgcacgccgg gatgtccacg gtgaccggat tcaagcccga
    10021 gactcgggcg atcacggtgc cggaccccca ttcacgtgcc gtcctcgaca aggcggcccg
    10081 cgagaacttc cccgtcgcgc ccttcttcgt accccgctcc tggcgcgccg acctgatggc
    10141 ggtctacggc ttcgcccggc tcgtcgacga catcggcgac ggggacctgg ccgacggcgg
    10201 ccgcacggac gccgtgcggc tggggctgcc cgcggaggcg gccgaggacc gcctcgccat
    10261 gctcgacgcc ttcgaggcgg acctgcgccg ggtcttcggc gacggccccg acgacgtccg
    10321 ccacccgctg ctccgcgcgc tgcggcccac cgtccggcgg cacggcctga cgccggcccc
    10381 cttcctcggc ctggtcgagg ccaaccgcca ggaccaggtc gtccgccgct acgccaccta
    10441 cgaggacctc ctcgcctact gcgagctgtc ggcgaacccg gtcggccgcc tcgtgctcgg
    10501 catcaccggc acggcgacac ccgagcggat ccgccgctcg gacgcgatct gcaccgcgct
    10561 gcagatcatc gaacacctcc aggacgtggc cgaggacctc ggccgcgacc gcatctacct
    10621 gcccgccgag gacatgaagc gcttcggcgt caccgaaacc gatctcaccg ccgcgaccgc
    10681 gggcgcacag gtgcgcgcac tggttgcgta cgaagcggaa cgcgcccgag acctcctgaa
    10741 tgaaggcacc ccgttggtgg gtagcgtcca cggcaggctc aggctgttgc tcgccgggtt
    10801 cgccggagga ggccgcgccg ccctgcgggc gatcgcggac gcggggtacg acgtgctgcc
    10861 cgggccgccc aaggcgggca ggttgagcct gctgcgcgag gtggggtcga cattgcgaag
    10921 agaggggtga gccggactgt gaacggctcc gatcgcatgt ccggacctgt gctcgcggcc
    10981 taccgctact gcgaggtcgt caccggccac gaggcaagga acttcgccta cggcatccgg
    11041 ctgctgccca cccccaaacg ccaggcgatg tccgccctct acgccttctc ccggcgggtg
    11101 gacgacatcg gcgacggcga cctcgacctc ccggagaagc agcggcggct cgacggcacc
    11161 cgggacctgc tcacccgggt ccaggagggc gccgtcaccg aggacgacac cgacccggtg
    11221 gccgtcgcgc tcgccgacgc cggccgccgc ttcccgatcc cgctcggcgg gctggaggaa
    11281 ctgatcgacg gcgtccagat ggacctgcgc ggtgacacct acgagacgtg ggaggacctc
    11341 gcgtcctact gccgttgcgt cgccggcgcc atcggcaggc tctcgctcgg cgtcttcggc
    11401 accgcgcccg gcgcacccgg ccgggagcgc gcggcggagt acgcggacac cctgggcctc
    11461 gccctgcaac tcaccaacat cctgcgggac ctgcgcgagg acgccgccaa cgggcgcacc
    11521 tacctgcccg cggacgacct cgcgaagttc ggctgttccg ccgggttcct caccgacacc
    11581 ccgccgcccg ggtccgactt cgcgggcctg atcgagtacg aggtgaagcg ggcccgcgcc
    11641 ctgttcgccg aggggtaccg gctgctgccg atgctggacc gccgcagcgg cgcctgcgtc
    11701 tcggccatgg ccggcatcta ccgccgcctc ctggaacgca tcgccgccga tcccgaggcc
    11761 gtcctgcgcg gccgggtctc gctgcccggc caccagaagg cgtacgtcgc ggcgcgcggc
    11821 ctcgccggtc tcgacgcccg acgtgccgcc aggaggcgcg tgtgacaccc gcgccaccgg
    11881 ccgcgggccc cttcacccgc accggcaaaa gcaccgcaac cggcacggga gcggcagcat
    11941 cgcggaaaac cactgttttc cgccgccgtg aggcaaccgc cgccgtgccg gcggcgtcac
    12001 tgtcggcaat ggtgcgccgc gccacgcgcg gcggcacccg ggggagggcg catggctgag
    12061 cgaacggccg tcgtgatcgg cggcgggctc gcggggacga cggcggcact ggcactggcc
    12121 gacgccggac tgcgcgtcac cctgctcgag gcccggcccc ggctgggcgg gctcgccttc
    12181 tccttccagc gcggcgacct gaccgtcgac aacgggcagc acgtcttcct gcgctgctgc
    12241 gtcgcctacc tgcggttcct tgagcgcatc gacgcggccg acctcgtcac cctccaggac
    12301 cggctcgacg taccggtact cgacgtggcg accccgcggc cccggctcgg ccggctgcgc
    12361 cgcgcggggc tgcccgtacc gctgcacctg gccgcgagcc tggccacgta cccgcatctc
    12421 tccctggccg agcgggcgtc cgtcgggcgc gccgcgctcg cgctgcgctc gctcgacccc
    12481 gccgacccgg cgctcgacga cgtggacttc ggcacctggc tgcgcgagca cggccagtcg
    12541 gcccgcacca tcgaggcgct gtgggacctg gtcggcgtgg ccacgctcaa cgccacggcc
    12601 gacgaggcgt cactgggcct ggccgccaag gtcttcaaga ccggcctgct ctccgccccg
    12661 ggcgccgcgg acatcggctg ggccgcccgg ccgctcggcg agctgcacga cgaccgcgcc
    12721 cgcaccgccc tggacaaggc gggcgtgcgc accctgctgc gcacccgcgc cacctcgctc
    12781 acccgcacgg acgcgtccga gccggtacgg tccggcgacg gcggccccgg gggcggcgga
    12841 ccggtctggg aggtcgaggc cgagaccgga cccggacgcg ccgagcgctt cacggcggac
    12901 acggtcgtcc tggccgtgcc ccagcaggag gcccacgggc tgctccccgc gggcgccctg
    12961 gccgaccagg acgcgctgct gcgcatcggc accgcgccga tcctcaacgt gcacgtcgtg
    13021 tacgaccgcc aggtcatgcg gcagccgttc ttcgccgccc tcggcagccc cgtgcagtgg
    13081 gtcttcgacc gcacggagca ctccggactc accggcggcg gccagtacgt cgccctgtcc
    13141 cagtcggcgg cccaggagga gatcgacctc ccggtggccg agctgcgaaa gcgctacctg
    13201 ccggagctgg agcggctgct cccggtcgcg cgcgaagccg ccgtactgga cttcttcgtc
    13261 accagggaac ggaccgcgac cttcgcgccc ctccccggtg tcggcgccct ccgcccgggt
    13321 gcccgcaccc gggcggacgg cgtctggctc gccggcgcct ggaccgccac cggctggccc
    13381 gcgacgatgg aaagcgcggt ccgcagcggt ttgcaagcct cccgagcagc tttgaccgca
    13441 ctccgccatc ccttcgaccc acgtaccttc gcaatcgaag gcctggagcc ggtatgagca
    13501 tgaccagtgc aatcagagga gagaatgtga ccgctggcaa cgagcagatg accgcgggcg
    13561 tcgacagagc gaccgtgacc gcgctcctgg agcgcggccg cgagctgtcc acgccggtgc
    13621 tgcgcgccgc cgtggaccgc ctcgcacccc cgatggacac cgtcgccgcc taccacttcg
    13681 gatggatcga cgccgcgggc aacccgtccc acggcgacag cggcaaggcc gtacgtcccg
    13741 cactcgccct gctgtccgcc gaggcggcgg gcgccgctcc ggaggtgggc gtccccgggg
    13801 cggtcgccgt ggagctggtg cacaacttct ccctgctgca cgacgacctg atggacggtg
    13861 acgagcagcg ccgccaccgc gacaccgtct ggaaggtgca cggccccgcc caggccatcc
    13921 tggtcggcga cgcgctcttc gccctcgcca acgagatcct gctggagcag ggcaccgtcg
    13981 aggccggccg ggccacccgc cggatcacca ccgcgacccg caagctgatc gacggtcagg
    14041 cccaggacat ctccttcgag caccgcgagc gggtcaccgt cgaggagtgc ctggagatgg
    14101 agggcaacaa gaccggcgcc ctcctggcct gcgcctgctc catcggcgcg gtgctcggcg
    14161 gcgcctccga ggccgacgcc gacgccctgg aggagtacgg ctaccacctc ggtctgtcgt
    14221 tccaggccat cgacgacctg ctgggcatct ggggcgaccc ggccgccacc ggcaagcaga
    14281 cctggagcga cctgcggcag cgcaagaagt ccctgccggt ggtcgccgcg ctggccgcgg
    14341 gcggctccgc ctcgcggcgc ctcgccgaac tcctggccgc ggacgcgaag gccgcggatt
    14401 cgtcggaacg cagcgacatc gagtccttcg acgaggaaga gttcgccaca cgcgcggcgt
    14461 tgatcgaaga agccggcggc cgggagtgga cttcccggga agcccgccgg cagtacgcca
    14521 ccgcgatcgc cgcactcgac aaaatggaca tgccgggaga agttcgccgt aagctcgtgg
    14581 gtctggcgga tttcgtggtg gttcgcgaga agtaaagaca caactggagc gcagtacgtc
    14641 gccggccggg cgcgcgtgac ggccgacggc agccccaaca ccgcagacgg aacgactgtg
    14701 caaaggggaa gccatgacag cgacgaccga cggcggtccc gggggcgagg cggcccgcgg
    14761 gacaccctcg gccagaacga agacctcggg cgcgatcccg gagccggcgt caggtcccgg
    14821 gaccggcggc ctctccggcc ggaccgagga gctcgcggcc gaggccgcgc gccgggccac
    14881 cggccacctg ctggcccgcc agcatcctga cggctggtgg aagggcgacc tcgagaccaa
    14941 cgtcacgatg gacgccgagg acctgctgct ccgtcagttc ctcggcatcc aggacgagac
    15001 ggtcaccggg gccgccggcc gctggatcag gtcccagcag cgtgaggacg gcgcctggcc
    15061 caccttccac ggcgggcccg gcgacctgtc ggccaccgtc gaggcctacg tcgcgctgcg
    15121 gctcgcggga gacgccccgg aggagccgtg gatggccgcc gcgtcggcct tcgtgcgcga
    15181 gcggggcggc atcgcccggt gccgggtctt cacccggatc tggctcgcgc tgttcggctg
    15241 gtggcgctgg gacgacctcc cggagctgcc gcccgagctc atctacctgc ccaagtgggt
    15301 cccgctcaac atctactcct tcgccagctg ggcccggcag accatcgtgc cgctcaccat
    15361 cgtcgccgcc caccggccgg tacggcccgc cccgttcgtc ctcgacgagc tgcacaccga
    15421 ccccgcgcgg cccaacccgc cggtcccgcg ggcgccgctg tccagctggg acgggttctt
    15481 ccagcggctc gaccgggccc tgcacgccta ccgcaaggtc agcgtccgtc cgctgcggcg
    15541 ggccgcgatg cgctcggcgg cgcgctggat catcgaacgc caggagaacg acggctgctt
    15601 cggcggcatc cagccgcccg ccgtgtactc cgtcatcgcg ctccacctgc tcggctacga
    15661 cctcgaccac cccgtgctgc gcgccggact caaggcgctc gacgagttcg cggtctggcc
    15721 ggacaaggac acgcggatga tcgaggcgtg ccagtccccg gtctgggaca cctgcctcgc
    15781 caccatcgcg ctggccgacg cgggtgtgcc cgccgacgac cccgcgctgg tcaaggcggt
    15841 ggactggatg ctgggagagc agatcaccaa gtccggggac tgggccgtgc aacggcccgg
    15901 gctgccctcg ggcggctggg cgttcgagtt ccagaacgac acctaccccg acatcgacga
    15961 caccgcggag gtcgtcctcg ccctgatcag ggtcgaccac ccggagccgg agcgggtgaa
    16021 ggcctcggtc gaccgggggg tgcgctggaa cgtcgggatg cagtcgaaga acggcgcctg
    16081 gggcgccttc gacgccgaca acaccagcgc cttccccaac cggctgccct tctgcgactt
    16141 cggcgaggtc atcgacccgc cgtcggccga cgtcacggcc cacgtggtcg agatgctggc
    16201 cgccctcggc ctggagcacg ccccgcacac ccggcgcggg atcgactggc tgctcgccga
    16261 acaggagcgc agcggtgcct ggttcggccg ctggggcgtc aactacatct acggcaccgg
    16321 gtcggtggtc ccggccctcg tggcggccgg cctcccggcg gcccaccccg cgatccggcg
    16381 ggcggtgggc tggctggagt ccgtgcagaa cgaggacggg ggctggggcg aggacctgcg
    16441 ctcgtactcc ttggccgagt gggccggccg cggcgagtcc acggcctccc agacggcctg
    16501 ggcgctgctg gccctgctgg cggccggcga acgcgagggg gaggcggtac ggcgcggggt
    16561 gcgctggctg gccgggaccc agaacgagga cgggtcctgg gacgagccgt acttcaccgg
    16621 caccggcttc cccagggact tctccatcaa ctaccacctc taccggatgg tcttcccgct
    16681 caccgcgctc gggcgctacg tgcgcgggga gccgttcggc gggctacgga agggggcctg
    16741 atggggccgt ccggcccagc cctggtcatc gtctgcgcgc tgcgggtgga acggttcgcc
    16801 cttcgcggcg gcgaccgcag ccacgcggcc ggcccggtcg ccttcgtgcg cacgggcatg
    16861 gggccgcagg ccgcggaacg cgccgtcacc gccgcgctgc gcgatcccgc cctggacggt
    16921 gcggcggtcc tcaccaccgg cttctgcgcc ggtctggccc ccgggatgcg gccgggcgac
    16981 gtggtcgtcg ccgacgagcc gcccgacggg gaatcactcg ccgccgccct caaggcggcg
    17041 ggacacaccg tgcacgtggg ccggctcgcg gagtcggacc acgtcgtacg gggcccggag
    17101 cgggcggcgc tccgggccac cggtgccgtc gccgtcgaca tggagtcggc ggcgatgatg
    17161 cgggccgcgc tcgcccgggg tccacgcccg gtcgccgcgg cccgcgtggt cgtcgacacg
    17221 cccgagttcg agctcgtgcg ggtcggcacg ctccgcacgg ggatcaccgc tttccgcgtg
    17281 ctgagggacc ttcttcctgc ctttctcgat tggcaccgct ctactgcgct cccctggagg
    17341 tgagctagat ggccatgccg cttcgacagt ccatcagggt cggcacctac ctcttcgaac
    17401 agaaaatgct ccgcaggcgt gagaagttcc ctctcatcgt cgaactcgag ccgcttttcg
    17461 cctgcaacct gaaatgcgag ggctgcggga agatccagca cccggcggga gtgctgaagc
    17521 agcgcatgcc ggtggcacag gccgtgggcg ccgtcctgga atcgggcgca ccgatggtct
    17581 cgatcgccgg cggcgaaccg ctgatgcacc cgcagatcga cgagatcgtg cggcagctgg
    17641 tggcgaagag gaagtacgtc ttcctctgca ccaacgccat gctgctgcgc aagaagctgg
    17701 agaacttcac accctcgccc tacttcgcgt tcgccgtgca catcgacgga ctgcgcgagc
    17761 ggcacgacga gtcggtcgcg aaggaaggag tcttcgacga ggcggtcgag gcgatcaagg
    17821 aggccaagcg gcgcggtttc cgggtcacca ccaactcgac cttcttcaac accgacaccc
    17881 cgcagaccat catcgaggtc ctcaacttcc tcaatgacga cctgcaggtc gacgagatga
    17941 tgatctcgcc ggcctacgcc tacgagaagg ctcccgacca ggagcacttc ctcggcgtgg
    18001 aacagacccg cgaactgttc aagaaggcct tctcgggcgg caaccggaag aagtggcggc
    18061 tcaaccacag ccctctcttc ctggacttcc tcgagggcaa ggtcgacttc ccgtgcaccg
    18121 cctgggcgat tcccaactac tccctgttcg gctggcagcg cccctgctac ctgatgagcg
    18181 acggttacgt gaccacgtac aaggagctcg tcgaggacac cgactggagc aagtacggcc
    18241 gcggcaagga tccgcggtgc gccaactgca tggcgcactg cggctacgag ccgaccgccg
    18301 tcctggccac gatgacctcc ctcaaggagt ccatcagggc gacccgggag accgtcaccg
    18361 gcaaccgcgg gaagtgacgt cgcgatgaaa gctgtcgagc ccgtcgcgct cggcctgccg
    18421 tccgtgccgg cccggccact cgcggagcgc cgccgttcgc ggcgcatcca ggtcgggccg
    18481 gtggcggtgg gcggcgacgc ccccgtctcg gtccagtcga tgacgaccac gctcaccgcc
    18541 gacgtcaacg cgacgctgca gcagatcgcc gaactgacgg cgtccggctg ccagatcgtc
    18601 cgtgtggcct gcccgtcgca ggacgacgcg gacgcgctgg cgcagatcgc gaggaagtcg
    18661 cagatcccgg tgatcgcgga catccacttc cagccgaagt acgtgttcgc ggcgatcgac
    18721 gcggggtgtg cggcggtgcg
//
