LOCUS       NZ_FZOF01000020        10228 bp    DNA     linear   CON 02-JAN-2025
DEFINITION  Actinacidiphila glaucinigra strain CGMCC 4.1858, whole genome
            shotgun sequence.
ACCESSION   NZ_FZOF01000020
VERSION     NZ_FZOF01000020.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinacidiphila glaucinigra
  ORGANISM  Actinacidiphila glaucinigra
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Actinacidiphila.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900188405.1-RS_2025_01_02
            Annotation Date                   :: 01/02/2025 02:14:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,793
            CDSs (total)                      :: 8,707
            Genes (coding)                    :: 8,547
            CDSs (with protein)               :: 8,547
            Genes (RNA)                       :: 86
            rRNAs                             :: 5, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1 (5S, 16S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 160
            CDSs (without protein)            :: 160
            Pseudo Genes (ambiguous residues) :: 0 of 160
            Pseudo Genes (frameshifted)       :: 47 of 160
            Pseudo Genes (incomplete)         :: 136 of 160
            Pseudo Genes (internal stop)      :: 6 of 160
            Pseudo Genes (multiple problems)  :: 29 of 160
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:25:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 57220
            Orig. end                         :: 67448
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FZOF01000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10228
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10228
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10228
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5228](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5228)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(1529..1542)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.87"
                     /tool="antismash"
     gene            complement(1835..4093)
                     /locus_tag="CHF15_RS29995"
                     /old_locus_tag="SAMN05216252_12047"
     CDS             complement(1835..4093)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558043.1"
                     /locus_tag="CHF15_RS29995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_12047"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_089227038.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.5e-38, bitscore:
                     125.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPTARPQQRPLPPDGRRRHRPEPARTRRQRPRRRPRTVRTPTV
                     LQMEAVECGAASLAMVLGHYGRHVPLEELRIACGVSRDGSRASNLLKAARGYGLQAKGM
                     QMETAALAEVQAPAILFWEFNHYVVYDGTGRRLGRRGVHVNDPDKGRRFVPVEDFDTSF
                     TGVVLTFEPGPDFHRGGRRPGVLGALPARLRGTSGTMLAALVASLLLVAVGAALPALSR
                     TYIDLFLIGEQTSLLGVLFASMAVLVALTAALTAVQQSNLLRGRIISSTLGSARFLRHL
                     LRLPVTFFTQRSPADLVQRLQSNDAVAETLARDLAAAAVDGVVVVLYALLMWTYDPQLT
                     VLGVGIALLNAVAMRVVTRLRATRTQKLRADSARLTNTSYTGLQLIETMKATGGENGYF
                     RRWAGQHASTLEEQQRLGVPSAWLSVVAPTLATLNSALILWIGGLRAVEGHISIGLLVA
                     FQALVTRFTAPITRLNGVAGRIQDFAADVVRLKDVENFPVDSLYARPESGASNRRLRGH
                     VTLEDVTFGYSPLDKPLLSGFSLSVAPGRQVALVGGSGSGKSTVSRLIAGLYSPWEGTI
                     RIDGTRLEDIPRGALAASVSFVDQDVFLFEGTVRDNVALWDPSIPDGDVEAALRDACLY
                     EVVARRPGGLHSRVEQDGRNFSGGQRQRLEIARALVRRPSVLVLDEVTSALDAETEQAI
                     IDNLRRRGCACVVIAHRLSTVRDSDEILVLDHGTVVERGRHEELIAAGGAYAALVKEH"
     gene            complement(4090..4896)
                     /locus_tag="CHF15_RS30000"
                     /old_locus_tag="SAMN05216252_12048"
     CDS             complement(4090..4896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="CHF15_RS30000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_12048"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_089227039.1"
                     /transl_table=11
                     /translation="MQFRQKALAKLQSPEALDLPVRFARPQGRLVLAVAILVIAAASSW
                     AVNGSVSSKLSVPGIIGYGQGSYVLQSPVAGQVTRVLAEEGQRLPADAPLLNVRTARGD
                     TVVRTVAAGRVTALVASIGTVVTVGADVAAVERVARTGDPLVATLYVPATGASSVPVGA
                     AVDLTVESAPQARYGVLRGHVQTVGRTSRTARQIAADLGDPQLAAQLTRGGRPVAVVVR
                     LDASSRTPTGYRWSKGDGPSYELDSMTLATGAVHLAAQRPIDWLLP"
     gene            complement(5001..5228)
                     /locus_tag="CHF15_RS30005"
                     /old_locus_tag="SAMN05216252_12049"
     CDS             complement(5001..5228)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157700.1"
                     /locus_tag="CHF15_RS30005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_12049"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_089227040.1"
                     /sec_met_domain="strepbact (E-value: 9.6e-29, bitscore:
                     93.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTSQVETREISDADLDNVSGGLVGGLVASATGTVESIAPVAGT
                     VSGVVGTVEGISGVNTGAVTGLATGLIAGL"
     gene            complement(5645..6364)
                     /locus_tag="CHF15_RS30010"
                     /old_locus_tag="SAMN05216252_12050"
     CDS             complement(5645..6364)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.5"
                     /locus_tag="CHF15_RS30010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_12050"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_089227041.1"
                     /transl_table=11
                     /translation="MGDTRGDELLIGDPADLPTTGGASGPAPARTPGRAATTRQALLKA
                     AREVFGESGYAAAGIAEVVRRADASVGGLYHHFDGKVDLFLALWEEFRTAQAQTTARAV
                     ARLRETGESRPRALFLTGTRAYLEHTRARREMARLFYTGDTPPGFDLLGRQNLRTWISH
                     NATLLGITHERPGDRALLIALTTTIAEIGRELVVCDDAREAADLTDTALELIGRLCDFG
                     LSGTEGDAAGRARPATA"
     gene            complement(6444..7760)
                     /locus_tag="CHF15_RS30015"
                     /old_locus_tag="SAMN05216252_12051"
     CDS             complement(6444..7760)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1282:
                     extracellular ligand-binding receptor"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558047.1"
                     /locus_tag="CHF15_RS30015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_12051"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_089227042.1"
                     /transl_table=11
                     /translation="MRRSHRHGLRLRGGAALAVLALVLTACSGGSGGGSAAPGVTEDSI
                     VIGSHQPLTGPAAPGYSNVSAGAKAYFDHVNANGGVNGRKIDFRYKDDAYNPTQTVKVT
                     KELVLEDKIFAMVGGLGTPTHTKVVDFLNSRRVPDLFVSSGCRCWDQPDKHPQTFGWQP
                     DYLVEGKILGQYIKENFAGKKVAYFYQGDDFGKDGVEGLDQYIPKESVVSRQSYQPGGT
                     DIAPQVTAIAQSKADVVVLFTIPTYTALFKLTSLKLQYNPQMVVTNVGSDPTTLAGLLQ
                     SFAKQAGGTADPAALMDGIITDTYMPPTNDASNSWIKLFRGIHDKYIPKLPFDGNVEFG
                     MSMAYTFVQALQGAGKNPTRESLVKAVEKGGFTGPGLVPFRFSGDSHAGYTGVQIGILK
                     GSTEVALQGTPLVTDDEQGAITPYTTAPPEAPANGIPAS"
     gene            complement(7849..8943)
                     /locus_tag="CHF15_RS30020"
                     /old_locus_tag="SAMN05216252_12052"
     CDS             complement(7849..8943)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1113:
                     inner-membrane translocator"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558048.1"
                     /locus_tag="CHF15_RS30020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_12052"
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="WP_179280027.1"
                     /transl_table=11
                     /translation="MTDTTDTSKDLGSPLGGPAAAGLAARLRGPMDRTAVRHLVPALLG
                     LLVVCGVSALLSPFQNLEVATVATYVCAVAGLTVLTGTNGQISLGHGALMAAGAYGTGL
                     FLTELGWSLAVSLLAGTAVAAALGALVGAAAARLQGPYLAGATLTLAVGLPALANYRHL
                     TDLLGGENGLVVDSPPPPEALGPYFPMERWQAWVCVLCAVVVLVLLADLGRSRVGRSWR
                     AIRDDEVSAALAGIHVARLRVLAFVVSAACAGLGGALLAVVSSLAAPGAFPLALSLSLL
                     TAAVLGGLGSLAGAVYGSVLLVLLPNWTGDVADALHLSRGFYANLPLALYGLALVLSML
                     LFPQGIQGALIRLVRRLRTRGSGT"
     gene            complement(8951..9826)
                     /locus_tag="CHF15_RS30025"
                     /old_locus_tag="SAMN05216252_12053"
     CDS             complement(8951..9826)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0015658 - branched-chain amino acid
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558049.1"
                     /locus_tag="CHF15_RS30025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_12053"
                     /product="branched-chain amino acid ABC transporter
                     permease"
                     /protein_id="WP_089227043.1"
                     /transl_table=11
                     /translation="MYFINLTLGGVSSGIVYAAVALALVLIWRATRIVNFAQGGMLMIT
                     TFVALGVIDATGSYWLGLLAALVSGFVLGAVVERVLVRPIENGPPMNAVIVTLGLLLFL
                     QAVAGMVWGGSPRSFPPLLGIKGFTVGDARLLLSPSDLFVIGAVLVVMALLVLLFRVTP
                     VGLRMRAAAFSPEVARMFGVRVGRVLTLGWALAGAVGALAGVLVAPATFVGPNQFDAVL
                     VFGFAAAVVGGLDSPPGAVVGGLVVGLTLSYVSGYLGSEVALLGALAVLMTVLMIRPNG
                     LFSRTSVRRV"
ORIGIN
        1 gcgggcccac gcggcatacg cgaagctctc cgcggcggcg acgcggagct tgggcaggcc
       61 gcgcagggtc tggaaggcct cgttgttgag cttgttgccg agttccacca gccttcgctg
      121 ccagcgcagt tcccacaggc cgagcccgag gagcaggacg ccgatgacga cgagcatgcc
      181 gagggcggcg agcgccagcg ggacgctgta caggagcagc aggacgaggt tcatcgcgcc
      241 gaccgtcgtc gcctggaccg cgaccgggcc gacccccgcg agcacgcggc ggatggcgct
      301 gatgcccatc gcggcactgg cgagctcacc cgtggagcgc ccggcgaaga acccggtcgg
      361 cagacgcagc aggcggtccc acaccgcggg ctgcagggtg gcctcgatac ggccctcgat
      421 gcggagcacg gtgaggttct gcgtcagcat gaacgcggcg cacaccaggc cggtgacggc
      481 gacggcgagc gcggcctgga cgatgagccc gctctcggcg tcgggtacgt acgtgcccag
      541 cacctgcccg gtcgcgatgg gcacgagcgc gccgaggccg acggtgacca tgctgctgag
      601 gacgaggttg cgcagatcgc ccgtggagcc ccggaggctg aagcgcagca gccgcgccag
      661 cccggctccc cgttcgggga gcggccggta gagcatgtcc gcgcgctgct cgaagtcctc
      721 cgcgttgtac tcggcgaccc gtacgcggct gccgccgccg ggcccgaccg cctcgtagcc
      781 gccgcgccgc cacagcaggg ccaccggcgc gccggacgcg gcgcgccggc cgacgagggg
      841 gccggtgttc tcccgccacc actcgccgtc gaggcgcacc gggcggctgc ggatgccgga
      901 ggtgagcgcg acccgctcga cggggtccat gcggtcgctg acggcaccgc tgcgcgaggg
      961 cgggacgagg gtgatcccgg cggcctcggc gacctggcgg cagacggcgt acgtcgcgtc
     1021 gtcggaaggg gccgcggcgg tacgcgaggg ggctttgcgg gaggtggcga tggaggccag
     1081 cagatcgcgg tccgcctgtt cccggacggc ctccccggcc ttgatgcccg cggccgtacg
     1141 gtcctcgtgg gcgcgttcca tgccctcgat ccagccgtcg agcgtggaca gcaaccggta
     1201 ctgctggttg accatgctct gccacatcgt gccgtcgatc agcaggtcgc ccgccgcctc
     1261 cgcggagtac gcggcaccgt actgcacgct gcccggcagg accggcagcc acaggatgtc
     1321 gtcgtcggcg acgtgctcgg cgccggtggc gcggccggtc aacggggcct cgtacagcac
     1381 gcgctggctg cggccgacgc cgagcgcgaa ggcgtgctcg aggaggctga gggcgagctc
     1441 ccgggtgtcg tggccggcgc cgtacgggcc ctgccggtcc cagccgtcgc cgtacgccgc
     1501 ctgctgcggg tggggcggcc ggtacagctc gcgcagcggg acgcggcgca ggtggcagcc
     1561 ctgcagcggg cggccgacga gggtgtgccg gggcccctcg accgggccga gcaggagggt
     1621 gccgggttcc aggcggccca ggtagtgcca gtggccctgc tgggccgcgt cgaccgcgaa
     1681 caggtcgagc gcgcccgcca ccacgagcca cagcacgtgc ggcccctcca gcgggaggct
     1741 gcgcaggccg gtgcagtcga ggggggtgcc cagcccgccg agggcggcca ggaccgggtc
     1801 gtcggcggcg gtgccgggct ccacgggggt caactcagtg ctccttgacc agtgcggcgt
     1861 acgcgccgcc cgcggcgatg agttcctcgt ggcgcccgcg ctcgacgacc gtgccgtggt
     1921 cgaggaccag gatctcgtcg ctgtcgcgga ccgtgctgag ccggtgcgcg atcaccacgc
     1981 aggcgcagcc gcggcgccgc aggttgtcga tgatggcctg ctcggtctcc gcgtcgaggg
     2041 cgctggtcac ctcgtcgagc accagcacgc tgggccgccg gaccagggcc cgggcgatct
     2101 ccagccgctg ccgctggccg ccggagaagt tgcggccgtc ctgttcgacg cggctgtgga
     2161 ggccgccggg gcgccgcgcg accacctcgt acaggcaggc gtcgcgcagc gctgcctcca
     2221 cgtccccgtc ggggatggag gggtcccaca gcgccacgtt gtcgcgcacc gtgccctcga
     2281 agaggaagac gtcctggtcg acgaacgaga cggacgcggc cagcgcgccg cgcgggatgt
     2341 cctccaggcg cgtcccgtcg atgcggatcg tgccctccca ggggctgtag agccccgcga
     2401 tgagccggga gacggtggac ttgccgctgc ccgagccgcc gaccagcgcg acctggcggc
     2461 cgggggcgac ggagagcgag aagccggaca gcagcggctt gtcgaggggg ctgtagccga
     2521 aggtgacgtc ctccagcgtg acgtggcccc tcagacggcg gttgctcgcc ccggactccg
     2581 gacgcgcgta cagcgagtcg acggggaagt tctcgacgtc cttgagccgc accacgtcgg
     2641 cggcgaagtc ctggatgcgg ccggcgacgc cgttgagccg ggtgatgggc gcggtgaacc
     2701 gggtgaccag ggcctggaag gcgacgagca gaccgatcga gatgtgaccc tccaccgccc
     2761 gcagtccgcc gatccacagg atgagcgcgc tgttgagcgt ggcgagcgtc ggggcgacga
     2821 ccgacagcca ggcgctgggc acgccgagcc gctgctgctc ctccagggtg gaggcgtgct
     2881 gcccggccca gcggcggaag tagccgttct cgcccccggt ggccttcatc gtctcgatca
     2941 actgcaggcc ggtgtacgag gtgttggtga gccgggcgct gtcggcgcga agtttctgcg
     3001 tccgggtggc gcgcagccgg gtcaccacgc gcatggcgac cgcgttgagc agggcgatcc
     3061 ccaccccgag gacggtgagc tggggatcgt acgtccacat cagcagcgcg tagagcacca
     3121 cgacgacgcc gtcgacggcc gccgcggcca ggtcgcgggc gagggtctcg gcgaccgcgt
     3181 cgttggactg caggcgctgt acgaggtcgg ccgggctgcg ctgggtgaag aaggtgaccg
     3241 gcagccgcag caggtggcgc aggaagcggg cgctgccgag ggtggaggag atgatgcggc
     3301 cgcgcagcag gttggactgc tggaccgcgg tgagcgcggc ggtgagcgcg accaggacgg
     3361 ccatcgacgc gaacagcacg cccagcaggg aggtctgctc gccgatcagg aacaggtcga
     3421 tgtaggtgcg gctgagcgcg ggcagcgctg ctccgaccgc gaccagcagg aggctggcca
     3481 ccagcgcggc gagcatggtg ccgctggtgc cgcgcagccg ggccggaagg gcgccgagga
     3541 cgccgggcct gcggccgccg cggtggaagt ccgggcccgg ctcgaaggtg agcacgacac
     3601 cggtgaagct ggtgtcgaag tcctccaccg gaacgaaacg ccgccccttg tcggggtcgt
     3661 tgacgtggac gccgcgccgg ccgaggcggc ggcccgtgcc gtcgtagacg acgtagtggt
     3721 tgaactccca gaagaggatg gccggtgcct gcacctcggc gagggccgcg gtctccatct
     3781 gcatgccctt ggcctgcagg ccgtagccgc gggcggcctt gagcaggttg ctggcgcggg
     3841 agccgtcgcg ggagacgccg caggcgatgc gcagttcctc cagcggcacg tgccggccgt
     3901 agtggccgag caccatcgcc agggaggccg cgccgcactc caccgcctcc atctgcagca
     3961 cggtcggcgt gcggacggtg cgcggcctgc ggcgcggacg ctgccggcgg gtgcgtgcgg
     4021 gctcggggcg gtgtctgcgg cggccgtcgg gcggcagcgg ccgctgctgg ggccgggcgg
     4081 tcggcgcggt caagggagca gccaatcgat cgggcgctgt gcggccaggt ggacggcgcc
     4141 ggtggccagg gtcatggagt ccagctcgta cgagggaccg tcgcccttgg accagcggta
     4201 tccggtcggg gtgcgggagg aagcgtcgag tctcacgacg acggccaccg ggcgtccccc
     4261 gcgggtgagt tgcgccgcga gctgggggtc gccgaggtcg gcggcgatct gccgggcggt
     4321 gcgcgaggtg cggccgacgg tctgcacatg gccgcgcagc accccgtacc gggcctgggg
     4381 cgcggactcg acggtgaggt caaccgcggc gcccaccggt acagaggagg caccggtcgc
     4441 cgggacgtag agggtcgcga cgagcgggtc gccggtgcgg gcgacgcgtt cgacggccgc
     4501 cacgtccgcg ccgacggtga cgacggtgcc gatcgaggcc accagggcgg tgacccggcc
     4561 cgccgccacg gtgcggacga cggtgtcgcc gcgcgccgta cggacgttga gcagaggggc
     4621 gtcggcgggc aggcgctgcc cttcctcggc gaggacccgg gtgacctgtc cggcgaccgg
     4681 actctgcagg acgtaactgc cctgcccgta gccgataatt cccggtacgc tcaatttcga
     4741 ggacacggaa ccgtttaccg cccaggaact cgcggcggcg atcacgagaa tggcgacggc
     4801 cagtacgaga cggccctgcg ggcgcgcgaa acgcaccggg agatcgagcg cctccggtga
     4861 ttggagcttg gcaagggcct tttggcgaaa ctgcacggaa ctcttccctc agccgcatcc
     4921 ctcgccattg ggacacaagg ccgcaatggc gtccgcgggt cccggaaggg aggcatccgg
     4981 gacccgcgga tccatttgtg tcagagaccc gcgatcaggc cggtggccag gccggtcacg
     5041 gcgccggtgt tgacgccgga gatgccctcg accgtgccga cgacaccgga gacggtgccg
     5101 gcgaccgggg cgatcgactc gacggtgccg gtggcgctgg ccacgaggcc gcccacgaga
     5161 ccgccggaga cgttgtccag gtccgcgtcg gagatctcgc gggtctcaac ctgggaggtg
     5221 aagtccatgg ggggtttccc ttcgtgtgaa cacatttcat gtggcgaatc atcagggggg
     5281 caacctcttc gccacggcac gggatacaag catgggagcc ggtggcgcgg ccaattgccg
     5341 atcagggcgt tcgaatttgg ttcggatcca tggcttcacc ggtgtgcgct gtttcccacc
     5401 tcgcggtggc aattccttca cacccgggga gggcgccgga gtcgcggaac cgggcactcc
     5461 ggatcaaacc gcgcgcaccg gtgcggggtg tcccgtgcgg acgtgcgggc gtatgtcgcc
     5521 cacgtgtgcg gtgtgcagat ttaccggagg taatgttcag ccctgcgctt gagccgggcc
     5581 tgccgccccg tgagcagggg tgatccacgg tgcgcgggca ccgggggccg atggcgggac
     5641 gggctcaggc ggtggccgga cgggcccggc cggcggcgtc tccctcggtg ccggacagcc
     5701 cgaagtcgca gagcctgccg atgagttcca gagcggtgtc ggtcaggtcc gcggcctcgc
     5761 gggcgtcgtc gcagacgacg agctcccgcc cgatctcggc gatcgtcgtc gtgagcgcga
     5821 tcagcagggc gcggtcgccc ggccgttcgt gggtgatgcc gagcagcgtc gcgttgtggc
     5881 tgatccaggt cctgaggttc tgccggccga gcaggtcgaa gcccggcggg gtgtccccgg
     5941 tgtagaagag cctggccatc tcccgccggg cccgggtgtg ctccaggtac gcgcgggtgc
     6001 cggtcaggaa gagggcgcgc gggcggctct cgccggtctc ccggagccgg gccaccgccc
     6061 gggccgtggt ctgcgcctgc gcggtgcgga actcctccca cagggccagg aagaggtcca
     6121 ccttgccgtc gaagtggtgg tagagcccgc cgacgctggc gtccgcgcgg cggaccacct
     6181 cggcgatgcc ggccgccgcg taccccgact ccccgaagac ctcgcgggcc gccttgagga
     6241 gcgcctgccg ggtggtcgcc gcccggccgg gcgtccgggc cggggccggc ccggacgccc
     6301 caccggtcgt gggaaggtcc gcgggatcgc cgatgagcag ctcgtcaccg cgtgtgtcgc
     6361 ccatcccggg accttccgtc cgtcacggtc gcgtcgcgcc gtgaacccac tgcctggagg
     6421 ggcagcacac tacccctggt cgttcaggac gccgggatgc cgttggccgg ggcctccggc
     6481 ggcgccgtgg tgtacggcgt gatggcgccc tgctcgtcgt ccgtcaccag cggcgtgccc
     6541 tgcagggcga cttcggtgct gcccttcagg atgccgatct ggacgccggt gtagcccgcg
     6601 tgggagtccc cgctgaaccg gaacggcacc agcccgggcc cggtgaatcc gcccttctcc
     6661 acggccttca ccagcgactc gcgcgtgggg ttcttcccgg cgccctgcag cgcctggacg
     6721 aaggtgtagg ccatggacat cccgaactcg acgttgccgt cgaagggcag cttcgggatg
     6781 tatttgtcgt ggatcccgcg gaagagcttg atccagctgt tggaggcgtc gttggtgggc
     6841 ggcatgtagg tgtcggtgat gatgccgtcc atgagcgccg ccgggtcggc cgtgccgccc
     6901 gcctgcttgg cgaaggactg cagcaggccc gccagggtgg tcgggtcgga accgacgttg
     6961 gtcaccacca tctgcgggtt gtactggagc ttgagcgagg tgagcttgaa cagcgcggtg
     7021 tacgtcggga tggtgaacag caccaccacg tccgccttgg actgggcgat ggccgtgacc
     7081 tgcggggcga tgtcggtgcc gccgggctgg tagctctgcc ggctgaccac cgactccttg
     7141 gggatgtact ggtccaggcc ctcgacgccg tccttgccga agtcgtcgcc ctggtagaag
     7201 taggcgacct tcttgcccgc gaagttctcc ttgatgtact ggccgaggat cttgccctcg
     7261 acgaggtagt ccggctgcca gccgaaggtc tgcgggtgct tgtcgggctg gtcccagcag
     7321 cggcagccgg aggacacgaa caggtccggc acgcggcggc tgttgaggaa gtcgaccacc
     7381 ttggtgtggg tcggcgtgcc gaggccgccc accatggcga agatcttgtc ctccaggacg
     7441 agttccttgg tgaccttcac cgtctgggtc gggttgtagg cgtcgtcctt gtaccggaag
     7501 tcgatcttcc ggccgttgac cccgccgttg gcgttgacgt ggtcgaagta cgccttggcg
     7561 cccgccgaga cgttgctgta cccgggtgcc gcgggcccgg tgagcggctg gtggctgccg
     7621 atgacgatgc tgtcctcggt gacgcccggc gcggcggaac cgccgccgga gccgcccgaa
     7681 caggcggtga gcaccagggc cagcacggcc agcgcggcgc cgccgcgcag acgcaggccg
     7741 tgtcggtgac ttcttctcat gacccctcct ggaaccgaat cggattcggt gggttttgaa
     7801 cggatttcac gtgacgtgcc ggtggttgac ggaacgggat gtggacggtc aggtaccgga
     7861 accccgggtg cggagccgcc ggaccagacg gatgagggcc ccttggatcc cttgcgggaa
     7921 caggagcatc gacaggacga gggcgaggcc gtacagggcc agcggcaggt tcgcgtagaa
     7981 gccccgggac aggtgcaggg cgtccgccac gtcccccgtc cagttgggca gcaggacgag
     8041 gagcaccgag ccgtacacgg cgcccgccag gctgcccagg ccgccgagca cggccgcggt
     8101 cagcagggac agcgagagcg ccagcgggaa cgcgccgggc gcggccagcg agctgaccac
     8161 cgcgaggagt gcgccgccca ggcccgcgca ggccgcgctg accacgaagg cgagcacccg
     8221 cagccgggcc acgtggatgc cggccagcgc cgcggagacc tcgtcgtccc ggatcgcccg
     8281 ccacgaccgg ccgacgcggc tgcgcccgag gtcggcgagg agcaccagca ccaccaccgc
     8341 gcacagcacg cagacccagg cctgccagcg ctccatcggg aagtacgggc ccagcgcctc
     8401 gggcggcggg ggcgagtcca ccacgagccc gttctcgccg ccgagcagat cggtcaggtg
     8461 ccggtagttg gcgagcgccg gcagcccgac ggccagggtg agggtcgcgc ccgcgaggta
     8521 cgggccctgc agccgcgccg cggcggcgcc caccagcgcg ccgagggcgg ccgcgaccgc
     8581 cgtgcccgcc agcagcgaga cggccagcga ccagcccagt tcggtgagga agaggccggt
     8641 cccgtaggcg cccgccgcca tcagcgcgcc gtgccccagc gagatctggc cgttggtccc
     8701 ggtcaggacg gtcagcccgg cgaccgcgca cacgtacgtg gcgacggtgg cgacctccag
     8761 gttctggaac ggcgacagca gcgcgctgac gccgcagacc accagcagcc cgagcagcgc
     8821 gggcaccagg tgccgtaccg cggtgcggtc catcggaccc cgcagccggg ccgccaggcc
     8881 ggcggccgcc gggcccccga gcggggaccc caggtccttc gaggtgtcgg tcgtgtcggt
     8941 catgtgcccc tcacacccgt cgcacggagg tacgcgagaa caggccgttg ggcctgatca
     9001 tcagcaccgt catcagcacc gccagcgcgc ccagcagcgc gacctcggac cccaggtacc
     9061 ccgagacgta ggagagggtg agcccgacca cgagcccgcc gaccaccgca ccgggcgggc
     9121 tgtccagccc cccgacgacg gcggcggcga aaccgaacac cagcaccgcg tcgaattggt
     9181 tgggcccgac gaaggtcgcc ggcgccacca ggaccccggc gagcgccccg accgcccccg
     9241 ccagcgccca gcccagcgtg agcacccgcc cgacccgcac cccgaacatc cgggccacct
     9301 cgggggagaa ggccgccgca cgcatccgca gccccaccgg ggtgacccgg aagagcagca
     9361 cgagcagcgc catcaccacc agcacggccc cgatgacgaa caggtccgag ggcgacagca
     9421 gcaaccgggc gtcgcccacc gtgaagccct tgatgcccag cagcggcggg aaggagcgcg
     9481 gcgaaccgcc ccacaccatc ccggccaccg cctgcaggaa cagcagcaga ccgagggtga
     9541 cgatcaccgc gttcatcggc ggcccgttct cgatcgggcg gaccagcacc cgctccacga
     9601 ccgcccccag gacgaacccc gagacgaggg cggccagcag cccgagccag tacgaacccg
     9661 tcgcgtcgat cacgccgagc gcgacgaagg tcgtgatcat cagcatgccg ccctgggcga
     9721 agttgacgat ccgggtcgcc cgccagatga gcaccagggc cagcgcgacc gcggcgtaga
     9781 cgatgccgct gctcaccccg cccagcgtca gattgatgaa gtacattcag aaccccagat
     9841 aggcgtggcg gaggtcgtcc gcggtggcga ggctcgcggc cgcgtcggac gcgaccaccc
     9901 gccccaggtt cagcacgacg ccgtggtccg cgacggacag ggcgctgcgc gcgttctgct
     9961 ccaccaggag cacggtgagc ccctgccgct cccgcaactc ccgcaggacc gcgaggatct
    10021 gcgcggtgac ccggggagcg agccccagcg acggctcgtc gagcagcagc agccgcggcc
    10081 gggtcatcag cgccctgccg atggccagca tctgccgttc gccgccggag agcgtctccg
    10141 cgagccgtgc gcgccgctcg gccagcgcgg ggaacagggc gtacacctcg tccagcccgg
    10201 tggactgcag cgccctgcgc tcgcgccg
//
