LOCUS       NZ_FZOF01000003        11386 bp    DNA     linear   CON 02-JAN-2025
DEFINITION  Actinacidiphila glaucinigra strain CGMCC 4.1858, whole genome
            shotgun sequence.
ACCESSION   NZ_FZOF01000003
VERSION     NZ_FZOF01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinacidiphila glaucinigra
  ORGANISM  Actinacidiphila glaucinigra
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Actinacidiphila.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900188405.1-RS_2025_01_02
            Annotation Date                   :: 01/02/2025 02:14:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,793
            CDSs (total)                      :: 8,707
            Genes (coding)                    :: 8,547
            CDSs (with protein)               :: 8,547
            Genes (RNA)                       :: 86
            rRNAs                             :: 5, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1 (5S, 16S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 160
            CDSs (without protein)            :: 160
            Pseudo Genes (ambiguous residues) :: 0 of 160
            Pseudo Genes (frameshifted)       :: 47 of 160
            Pseudo Genes (incomplete)         :: 136 of 160
            Pseudo Genes (internal stop)      :: 6 of 160
            Pseudo Genes (multiple problems)  :: 29 of 160
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:25:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 329177
            Orig. end                         :: 340563
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FZOF01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11386
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11386
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11386
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6386](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6386
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    395..411
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.59"
                     /tool="antismash"
     gene            1326..1949
                     /locus_tag="CHF15_RS08210"
                     /old_locus_tag="SAMN05216252_103296"
     CDS             1326..1949
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563197.1"
                     /locus_tag="CHF15_RS08210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103296"
                     /product="LysE family translocator"
                     /protein_id="WP_089222971.1"
                     /transl_table=11
                     /translation="MLSVLLPFLGACTLVAAAPGPSTVLIIRHSLRSRRAGFATVLGNE
                     TGVFVWGLCAAFGLTALLAASQLAYDAVRIVGAAVLVWFGVQALRAARRGADPGRAAAG
                     EDVTVTPWAAYRAGLGMNLANPKAAVFAMSFLPQFVPSGAPQLPAMVGLAALWAVYEVG
                     YYGAYVWFVDRLRSVFGRAAVRRRLEAVSGTVLVALGVRMALEG"
     gene            complement(1976..2647)
                     /locus_tag="CHF15_RS08215"
                     /old_locus_tag="SAMN05216252_103297"
     CDS             complement(1976..2647)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563198.1"
                     /locus_tag="CHF15_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103297"
                     /product="ABC transporter"
                     /protein_id="WP_089222972.1"
                     /transl_table=11
                     /translation="MTATLHYRTALLLRSFRWLPPLLLHLAVMAIGLAAGPRPLLDSLG
                     WSAAALLPAAAWLVRVSVTAEPPAARACVAAATGPGRAHTAGVLAALLCSVVLGAVSTA
                     VVVAVADPHTTDHLKAVPVVPAAAAGLLAALVTALLGTAVGALTNPPVLLRPGWAVPVT
                     ALTAVLVLVAAGSPANAAVTGLVTGSRTGVVPFPPAPLLLAAFAACGATWLAATLSGRR
                     G"
     gene            complement(2644..3468)
                     /locus_tag="CHF15_RS08220"
                     /old_locus_tag="SAMN05216252_103298"
     CDS             complement(2644..3468)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563199.1"
                     /locus_tag="CHF15_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103298"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_089222973.1"
                     /transl_table=11
                     /translation="MRLEAVGRRYGARGPWVLRGVDLDVPGGQVLRVEGANGSGKSTVL
                     RILAGIDRPTTGRVSGRPRTAYVPERFPPALPFDAHGYLVHLGRVHGLGGRTAARRAER
                     WLECFGIAGYARTPLAQLSKGTCQKVAVAQALVAEPELLVLDEAWTGLDEDARAVLDDA
                     VRARSAAGGTVVFVDHDPRRLAADTTAAHRVQDARLVPVPPDAAGGPRVVIEATGGGVP
                     PAGLAYEPAAPGTLQVTVPAAESDAVLRRLLAAAPPWHIRSVRPAQPPTEPA"
     gene            complement(3470..4144)
                     /locus_tag="CHF15_RS08225"
                     /old_locus_tag="SAMN05216252_103299"
     CDS             complement(3470..4144)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378552.1"
                     /locus_tag="CHF15_RS08225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103299"
                     /product="AIM24 family protein"
                     /protein_id="WP_089222974.1"
                     /transl_table=11
                     /translation="MHSDLFATENTAQPATEPGMTLQNAKSIKYAVNGECLARQGSMIA
                     FRGNLQFEVKGQGVGKFLKRAFTGEGLPLMSVRGQGEAWFAHEAANCFVVDLDPGDSLT
                     VNGRNVLVFDSTLSYEIKVVKGAGMAGGGLFNSVFTGHGRLGVMCEGNPIVIPVTPQAP
                     VYVDTDAVVGWSAQLQTSLHRSQSFGSMLRGGSGEAVQLMLQGEGFVIVRPSESTPHQP
                     SN"
     gene            4213..4893
                     /locus_tag="CHF15_RS08230"
                     /old_locus_tag="SAMN05216252_103300"
     CDS             4213..4893
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554825.1"
                     /locus_tag="CHF15_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103300"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_089222975.1"
                     /transl_table=11
                     /translation="MTTDPRDAAPQFVLPLVVRIERAAPPARTDALETAARAVLLLRSD
                     ERATLADGEWAEAVRGWEDARIRKVVRRARGAEWRRAETLPGITVTGKSAEIRVFPPVP
                     LDGWPKDLARLQVSGTELEDPEPPVAPEGGTPVLWLNPGVQMSAGKAMAQAGHGAQLAW
                     LALSAAERAHWRDTGFPLAVRTAPQDRWEALTASGLPVVRDAGFTEIAPGSCTVVADHP
                     ALRR"
     gene            5001..6386
                     /locus_tag="CHF15_RS08235"
                     /old_locus_tag="SAMN05216252_103301"
     CDS             5001..6386
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563202.1"
                     /locus_tag="CHF15_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103301"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_089222976.1"
                     /sec_met_domain="DUF692 (E-value: 2.9e-96, bitscore: 316.6,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHSYLGTGIGWRPEIAAAVEALAEAGRVDWVEAVAENVCPGALP
                     DSLLRLRERGVTVVPHGVSLGLGGAERPGADRLAALAQRAQALGAPLVTEHIAFVRGGG
                     ELTGSARLEAGHLLPVPRTRDALDVLCENVRIAQDALPVPLALENIAALVAWPDEEMSE
                     GAFLAELVERTGVRLLIDVANLHTNHVNRGEDPLAALDALPVHAIAYVHVAGGFEKDGV
                     WHDSHAHPVPEAVLEVLAALYERACPPGVLLERDDDFPSDGELAGELAAIRRVVDAGTG
                     VRPEVPPDVPGRAAAAPGASGAAGASGAARQRLALRQTALLSALVAGTPVPEGFDRTRI
                     GVQSRALAAKRAGVVAKVAPELPEILGAAYRPAFLRYAVVRPFAGGYRRDALDFAAYVL
                     DGRGGTHGPTVTRQLAAWWRERSGPAPLPARRPRLRGRVFPGPRQPSHVFIRMRDTLRS
                     KLP"
     gene            6548..7285
                     /locus_tag="CHF15_RS08240"
                     /old_locus_tag="SAMN05216252_103302"
     CDS             6548..7285
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563203.1"
                     /locus_tag="CHF15_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103302"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_089222977.1"
                     /transl_table=11
                     /translation="MRSTRYATGLSLVVGALVVTLAALAYPVMSGLNSPAVTAAGAQTV
                     STQYGPLTQLDRTFVTKVRLAGLWEFPAGQMGLQKGTTPAVKRAGQHLIDGHTSLDATC
                     RTIAPQLGITLPNQPTQQQMGFLATMSSASGQDFDQKFANILRLAHGQVFSVVAQVRAT
                     TRNSLVRELADQANATVLDHITVLEKTGMVNFDQVAVDTTASPTNPAAAVPVSPAPGEP
                     TLIVTPSPTYSLPPAASSPQPSQ"
     gene            7300..8457
                     /locus_tag="CHF15_RS08245"
                     /old_locus_tag="SAMN05216252_103303"
     CDS             7300..8457
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563204.1"
                     /locus_tag="CHF15_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103303"
                     /product="DUF1996 domain-containing protein"
                     /protein_id="WP_245938723.1"
                     /transl_table=11
                     /translation="MPTRQHMNHRRRLSTKQLVLIAVLALLGSGGTFALVTGSASAHWR
                     SNSGHSGGWQSPSPGNSTKADNGGQNNGGQNGSAAPSASASASASAPAGGGSQTNGPSR
                     EDFADIRSVKPNVQRAANQRGASRGTFTARCGRNENKHHNPDNFIVAPGVANGAHHVHD
                     YVGNLSTDGFSTNESLAAAGTTCARGDKSTYFWPVLRTRSANDAPDADGNTGTILQATS
                     VQLVFGGSPTSKVTAMPSTLRVIMGDAKSFTNGVANAKASWSCTGFENRQLTDKYPLCP
                     QGSRVVRTLNFPNCWDGTNADSANHRTHIVFADGAGRCQAGFKAVPQLKMRLTYKVPQG
                     PNFALDSFPEQLHKPVTDHADFANFMPTRLMNQVVSCINGNRNCG"
     gene            8730..9479
                     /locus_tag="CHF15_RS08250"
                     /old_locus_tag="SAMN05216252_103304"
     CDS             8730..9479
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563205.1"
                     /locus_tag="CHF15_RS08250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103304"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_089222979.1"
                     /transl_table=11
                     /translation="MWMLFLLVAWAAAIVSCTRLCRAAVAAADLPDGAAAPAADHTLGL
                     YEMAFLSGGPRRVTELTMVMMGRERRLLLARTGWATVVDPDGRDAVERSLIAATGPEGQ
                     APVPSIRAAHATSDGVRALAQRLTDAGLAVPTAARESISAAIREVRAAAALVLVMPAAA
                     TTLSPADRSVLPWFALPLPAALGCLAVARFEIHAYTRWAAPAGRDLLRAVDVPHGPAPD
                     DSRQILTALAVRGPSTLPDPALRAALS"
     gene            complement(9782..10513)
                     /gene="hemQ"
                     /locus_tag="CHF15_RS08255"
                     /old_locus_tag="SAMN05216252_103305"
     CDS             complement(9782..10513)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563206.1"
                     /locus_tag="CHF15_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216252_103305"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_018563206.1"
                     /transl_table=11
                     /translation="MTDSTASAAPAKAPNAGKKAKDLNEVIRYTLWSVFRLRDVLPDDR
                     IRYAEEVEELFAQLAEKDVTVRGTYDLSGLRADADVMIWWHSETADALQDAYNRFRRTL
                     LGRRLEPVWSNMALHRPAEFNKSHIPAFLADETARDYVSVYPFVRSYDWYLLPDEDRRR
                     MLADHGKMARGYPDVRANTVASFSLGDYEWILAFESDELHRIVDLMRHLRASEARMHVR
                     EEVPFYTGRRKSVADLVAGLA"
ORIGIN
        1 ttcgccgtac gaggaggcct accgggagac ccccggcaat ccgcaccgca aggtgctggt
       61 gatcggcgcg ggcaacggca acgacgtggc cgtcgcgctg gccaacggcg cgcagcacgt
      121 ggacgccgtc gagatcgacc cgcggctgca ggagatcggg gcgcagctgc accccgcgcg
      181 gccgtacgag aacccgcggg tgcacgtcca catcaacgac ggccgggcct tcctggagcg
      241 gacggacacg aagtacgacc tgatcgtgct ggccctgccg gactcgctca cgctggtgtc
      301 gggggcgagc aacctgcggc tggagagcta tctcttcacc aagcaggcct tcgagtcggc
      361 gcgtgaccac ctcgcgcccg gcggcgcgtt cgccatgtac aactactacc ggcagcaatg
      421 gctgatcgac cgcttcgccg ggagcctgga ccaggtcttc gggcacgcgc cgtgcatgac
      481 ggagtacagc aagcgcgccg cggtcctggt ggccgggctg acgccggcgg accagcgctg
      541 cgggaaggcc tggcaggcct ccggggcggt gcccccgccc gccgacgacg accacccctt
      601 cccgtacctg ctgaaccgca ccgtgccgag cctctacctc ggcgcgctcg gactgatcct
      661 gctggtcacc gtgatctcgg tgcggctggc cggggtgcgg ctgcgcggga cgctgcgcta
      721 cgccgacatg ttcctgatgg gcgcggcctt cctgctgctg gagacgaaga acgtcatcgg
      781 cttcgcgctg tacttcggca ccacctggct ggtgaacgcg ctggtcttca tcggggtgct
      841 gctggcggtg ctggccgccg tcgaggtgcg gcgccgcatg cgccggctca accagacggc
      901 gctgcagatc ctgctcttcg tcacgctcgc cgtcggctgg ctcgtcccgg tgcaggccgt
      961 gctgtcgctg cccttcgcgg cacgcctggc ggcagccgtc gcgctggcct tcgcgccgat
     1021 cttctgcgcc aacctgatct tctccgaccg cctcgccagg tcaccggacc cgacctccgc
     1081 cttcggcgcc aacctgctgg gcgccctgac gggcggtgcc ctggagtacc tggcgctgct
     1141 caccggctac cgggcgctgc tgatcctggt cgcggtgctg tacgccgggg cctgcgtggc
     1201 gatgcggctg tccggcggcg gcggtcccgg ggacggcgcg gacggcgcgg ggaagggcgg
     1261 gcaggacgtg gcggcgcagg ggaaccgtct ggtgcgcgag gggcccgctg cagcaccatg
     1321 acgggatgct gagcgtcctg ctgcccttcc tcggtgcctg caccctcgtc gccgcggccc
     1381 ccgggccgag cacggtgctg atcatcaggc actccctgcg cagccgccgg gccggcttcg
     1441 cgaccgtcct cggcaacgag accggtgtgt tcgtctgggg cctgtgcgcc gccttcgggc
     1501 tcaccgcgct cctggcggcc tcccagctcg cctacgacgc cgtacggatc gtcggcgccg
     1561 cggtcctggt ctggttcggc gtgcaggcgc tgcgtgccgc ccgccgcggc gcggaccccg
     1621 ggcgggccgc ggcgggtgag gacgtgacgg tgaccccgtg ggcggcctac cgcgcggggc
     1681 tcgggatgaa cctggccaat cccaaggcgg cggtcttcgc gatgtccttc ctgccgcagt
     1741 tcgtgccctc gggcgcgccc cagctccccg ccatggtcgg gctcgcggcg ctgtgggcgg
     1801 tctacgaggt cggctactac ggggcgtacg tctggttcgt cgaccgcctg aggtcggtgt
     1861 tcggccgcgc cgcggtgcgg cgccgtctgg aggcggtgtc cggcacggtg ctggtggcgc
     1921 tgggtgtccg gatggcgctg gagggctgag cgtcccccgt acccgcccgg gcccctcagc
     1981 cgcggcggcc gctgagcgtc gccgcgagcc aggtggcgcc gcaggcggcg aacgccgcca
     2041 gcaggagcgg cgccggcggg aacgggacga cgccggtacg ggaaccggtg acgagcccgg
     2101 tgaccgcggc gttggcgggc gatccggcgg ccacgaggac caggaccgcg gtgagggccg
     2161 tgacgggcac cgcccatccg gggcggagca gcaccggggg gttggtgagg gcgccgacgg
     2221 cggtgccgag cagcgcggtc accagggcgg ccaggagacc ggccgcggcc gccgggacga
     2281 ccggtacggc cttcaggtgg tccgtggtgt gcgggtcggc gacggcgacg accacggcgg
     2341 tgctcaccgc gcccaggacc accgagcaca gcagcgccgc caggacgccc gccgtgtggg
     2401 cccgccccgg tccggtggcg gccgccacac aggcacgtgc ggccggcggc tccgccgtca
     2461 cgctgacccg caccagccag gccgcggccg ggagcagcgc ggcggcgctc cagccgaggg
     2521 agtccagcag cggtcgcggc cccgcggcga gaccgatcgc catgacggcc aggtgcagca
     2581 gcagcggcgg cagccagcgg aaggaccgca ggagcagggc ggtccggtag tgcagggtcg
     2641 cggtcatgcg ggctccgtgg gcggctgcgc gggacgtacc gagcggatgt gccagggcgg
     2701 ggccgcggcg agcagccgcc gcaggacggc gtcggactcg gcggccggga cggtcacctg
     2761 cagcgtgccg ggcgcggcgg gctcgtacgc gagcccggcc ggcggcaccc cgccgccggt
     2821 ggcctcgatg acgacgcgcg gcccgccggc ggcgtccggc ggcaccggca cgagccgggc
     2881 gtcctggacg cggtgggccg ccgtggtgtc ggcggccagc cggcgcgggt cgtggtcgac
     2941 gaagacgacg gtgccgccgg cggcgctccg ggcgcgcacg gcgtcatcga ggacggcgcg
     3001 tgcgtcctcg tcgagcccgg tccacgcctc gtcgaggacg aggagttcgg gctcggccac
     3061 cagtgcctgg gcgaccgcca ccttctggca ggtgcccttg gacagctggg cgagcggggt
     3121 acgggcgtac cccgcgatgc cgaagcactc cagccagcgc tcggcccgcc gggcggcggt
     3181 gcggccgccg agcccgtgca cccgcccgag gtgcacgagg tagccgtgcg cgtcgaaggg
     3241 cagcgccggc gggaagcgct cgggcacgta cgcggtgcgc gggcgtccgc tgacccggcc
     3301 cgtggtgggg cggtcgatgc cggcgaggat ccgcaggacc gtggacttgc cgctgccgtt
     3361 cgccccctcg acgcgcagca cctgtccccc gggcacgtcg aggtcgaccc ctcgcagcac
     3421 ccagggcccg cgcgccccgt accggcggcc gaccgcctcc agccgcacgt cagttggagg
     3481 gctggtgagg tgtggactcg ctgggccgga cgatcacgaa gccctccccc tgcagcatca
     3541 gctgcacggc ctcgcccgag ccgccgcgca gcatcgagcc gaagctctgc gagcggtgca
     3601 gggaggtctg cagctgcgcg ctccagccga cgacggcgtc ggtgtcgacg tagaccgggg
     3661 cctgcggggt gaccgggatg acgatcgggt tgccctcgca catgacgccg aggcggccgt
     3721 gcccggtgaa gacgctgttg aacaggccgc cgccggccat cccggcaccc ttcacgacct
     3781 ttatctcgta ggagagggtc gagtcgaaga ccagcacgtt gcggccgttg acggtgaggc
     3841 tgtcgcccgg gtcgaggtcg acgacgaagc agttggcggc ctcgtgcgcg aaccaggcct
     3901 cgccctggcc gcggaccgac atcagcggca ggccctcgcc ggtgaaggcg cgcttgagga
     3961 acttgccgac gccctggccc ttcacctcga actgcaggtt gccgcggaag gcgatcatcg
     4021 agccctggcg ggccaggcac tcgccgttca ccgcgtactt gatcgacttg gcgttctgga
     4081 gggtcatgcc gggctcggtg gccggctgcg ccgtgttctc ggtcgcgaag aggtcgctgt
     4141 gcaccccggc atcctggccc ggagggatcg gctccgacaa gctcttccgg ggtcgggtgg
     4201 cagactgtcg aggtgacaac cgatcctcgt gacgccgcac cccagttcgt cctgcccctg
     4261 gtcgtccgca tcgagcgggc cgccccgccg gcgcgcaccg acgcactgga gacggccgcc
     4321 cgcgccgtgc tcctgctgcg ctccgacgag cgcgccaccc tcgcggacgg ggagtgggcc
     4381 gaggcggtac gcggctggga ggacgcccgc atccgcaagg tcgtacggcg ggcgcgcggc
     4441 gccgagtggc ggcgggccga gacgcttccc ggcatcacgg tcaccggcaa gtccgccgag
     4501 atccgcgtct tcccgccggt gccgctggac ggctggccca aggacctggc gcggctgcag
     4561 gtgtccggga cggaactgga ggacccggag ccgcccgtgg cgccggaggg cgggacgccg
     4621 gtgctctggc tcaacccggg ggtgcagatg tcggccggca aggccatggc gcaggccggg
     4681 cacggcgccc agctcgcctg gctcgcgctg tccgccgccg agcgcgcgca ctggcgcgac
     4741 accggtttcc cgctggcggt gcgcacggcg ccgcaggacc gctgggaggc gctcaccgcc
     4801 tccgggctgc ccgtggtgcg cgacgcgggg ttcaccgaga tcgccccggg gtcgtgcacc
     4861 gtcgtggcgg accatcccgc gctgcgccgc tgaggccgca ggctcggggc cccaagctca
     4921 aatcaagctc tgaaacccgc ctccccgggg ttcaccggcc ccgcgccggg cgagaacccc
     4981 cgcaggagga aggggggcgc atggagcact cgtatctggg cacgggcatc ggctggcggc
     5041 cggagatcgc ggcggcggtc gaggcgctcg cggaggccgg ccgcgtcgac tgggtcgagg
     5101 cggtcgccga gaacgtctgc cccggcgctc tgcccgactc cctgctgcga ctgcgcgagc
     5161 gcggtgtcac ggtcgtcccg cacggagtct cgctcggcct cgggggcgcc gagcggcccg
     5221 gcgcggaccg gctggccgcg ctcgcgcagc gcgcgcaggc gctgggcgcg ccgctggtca
     5281 ccgagcacat cgccttcgtc cgcggcggcg gggagctgac cggctcggcg cgcctggagg
     5341 cggggcacct gctgcccgtg ccgcggaccc gggacgcgct ggacgtgctg tgcgagaacg
     5401 tgcgcatcgc gcaggacgcg ctgccggtgc cgctcgcgct ggagaacatc gcggcactgg
     5461 tggcctggcc cgacgaggag atgagcgagg gcgccttcct cgccgagctc gtcgagcgga
     5521 ccggggtacg tctgctgatc gacgtcgcca acctgcacac gaaccacgtc aaccgcggtg
     5581 aggaccccct cgcggcgctc gacgcgctgc cggtgcacgc gatcgcctac gtccatgtgg
     5641 cgggcggttt cgagaaggac ggcgtgtggc acgacagcca cgcgcatccc gtccccgagg
     5701 cagtcctgga ggtgctggcg gcgctgtacg agcgggcctg cccgcccggt gtgctgctgg
     5761 agcgcgacga cgacttcccc tcggacgggg agctggccgg cgaactggcc gcgatacgcc
     5821 gcgtggtgga cgccggaacc ggcgtgcgcc cggaggtgcc gccggacgtg cccggcaggg
     5881 ccgccgcggc gcccggggcg tccggggcgg ccggggcgtc cggggcggcc cgccagcgcc
     5941 tcgcgctccg ccagaccgcg ctgctgtccg cactcgtggc cgggacaccg gtgccggagg
     6001 gcttcgaccg gacccggatc ggcgtgcaga gccgcgcgct ggccgccaag cgcgcgggcg
     6061 tcgtcgccaa ggtggcgccc gaactgccgg agatcctggg ggccgcgtac cgcccggcgt
     6121 tcctgcgcta cgccgtcgtg cggccgttcg cgggcggcta ccgccgcgac gccctggact
     6181 tcgccgcata cgtcctcgac ggccggggcg gaacgcacgg tcccacggtc acgcggcagt
     6241 tggccgcgtg gtggcgggaa cggtcgggcc cggcaccgct cccggcccgc aggccgcggc
     6301 tgcgcggaag ggtttttcca gggccgcgac agccctcaca cgtattcata cgtatgcggg
     6361 acacgctccg ttcaaagctg ccataatctt tttcaagagg cctccgacct gcggcggaaa
     6421 tggcggcggg ggtcatcggg cgcgaaaagg caacaacgta tcaaggtccg ggccgcgatt
     6481 catggaattc gcgaatacgt gactgttcct cgccttggac ggttcaaacg cactaacgtg
     6541 cggtcccatg cgatccaccc gttacgccac cggactcagc ctcgtggtcg gggctctcgt
     6601 ggtcaccctc gccgcactgg cctaccccgt catgtccggg ctgaacagcc cggccgtgac
     6661 cgcggccggc gcccagaccg tgtccacgca gtacggtccg ctcacccagc tggaccgcac
     6721 cttcgtcacc aaggtccgac tggccggctt gtgggagttc cccgccgggc agatgggcct
     6781 gcagaagggg acgacacccg cggtcaagcg cgcggggcag cacctcatcg acgggcacac
     6841 gagcctcgac gccacgtgcc gtacgatcgc gccccaattg ggcatcaccc ttcccaacca
     6901 gcccacacag cagcaaatgg gctttctggc caccatgtca tcggcgagcg ggcaggattt
     6961 cgaccagaag ttcgcgaata tcctgaggct cgcccacggc caggtgttct cggtcgtggc
     7021 ccaggtgcgt gccaccaccc gcaattcgct ggtacgggaa ctggccgacc aggcgaacgc
     7081 gacggtgctc gaccacatca ccgttctgga gaagaccggg atggtcaact tcgaccaggt
     7141 cgccgtggac acgaccgcca gccccaccaa ccccgcagcg gcggtgccgg tctcgcctgc
     7201 ccccggtgag ccgaccctca tcgtcacccc ctccccgacg tactcacttc ccccagcggc
     7261 ctcatccccc cagccgtcgc agtagaaatg agcgatccca tgcccacacg acaacacatg
     7321 aaccaccggc gcaggttgag caccaagcaa ctcgtgctga tagccgtgct ggcactgctc
     7381 ggctccggcg gaaccttcgc cctggtcacc ggatcggcct cggcacactg gcggtccaac
     7441 tccggccact cgggcggctg gcagagcccg agcccgggga acagcaccaa ggcggacaac
     7501 gggggccaga acaacggcgg ccagaacggc tccgcggctc cctccgcgtc cgcctcggcc
     7561 tcggcgtccg cgcccgccgg cggcggctcg cagaccaacg gcccctcccg cgaggacttc
     7621 gccgacatcc gctccgtcaa gcccaacgtc cagcgggcgg cgaaccagcg gggcgcctcg
     7681 cgcggcacgt tcacggcccg ctgcggccgc aacgagaaca agcaccacaa ccccgacaac
     7741 ttcatcgtgg cccccggcgt cgccaacggc gcgcaccacg tccacgacta cgtcggcaac
     7801 ctgagcaccg acggcttctc gacgaacgag tccctggccg cggccggcac cacctgcgcc
     7861 cgcggggaca agtcgacgta cttctggccg gtccttcgca cccgctccgc gaacgacgcg
     7921 ccggacgccg acggcaacac cggcaccatc ctgcaggcga cctcggtcca gctggtcttc
     7981 ggcggcagcc cgacgtccaa ggtgacggcg atgccgtcca ccctgcgggt catcatgggt
     8041 gacgccaagt ccttcaccaa cggcgtcgcc aacgccaagg cgtcgtggag ctgcacgggc
     8101 ttcgagaacc gccagctcac cgacaagtac ccgctgtgcc cgcagggcag ccgcgtggtc
     8161 cgcaccctga acttccccaa ctgctgggac gggacgaacg ccgacagcgc caaccaccgc
     8221 acgcacatcg tcttcgccga cggcgcggga cggtgccagg ccggcttcaa ggccgtgccc
     8281 cagctgaaga tgcggctgac ctacaaggtc ccgcagggtc cgaacttcgc gctcgacagc
     8341 ttccccgagc agctgcacaa gccggtcacg gaccacgcgg acttcgccaa cttcatgccg
     8401 acgcgcctga tgaaccaggt cgtgagctgc atcaacggca accgcaactg cggctgacgc
     8461 cgtagcgcgc acggcccccg ccggcaccgg tccgcccgcc ccgatccggg accccgcggg
     8521 cggacctcct gcgggggtcc gctaggccgt gtcgtcaaac gagcgccggc cgcccggagg
     8581 gcgggccccg cggtgtctgg tgcggtgcat cgcaaggcgg agagtcgtcc tcgtagtggg
     8641 ctactcggac gattcgacaa cgcagcgagg tgccgtgcca ggcgccgcgg ggcaggcggg
     8701 cgtttgacga cacggcctag aactccccca tgtggatgct cttcctgctc gtggcctggg
     8761 ccgcggcgat cgtctcctgc acacgcctgt gcagggcggc ggtcgccgcg gccgatctgc
     8821 ctgacggggc cgccgcaccg gccgccgacc acacgctcgg gctctacgag atggccttcc
     8881 tgtccggcgg accgcgccgg gtcaccgagc tgacgatggt catgatgggc cgcgaacgcc
     8941 gtctgctgct cgccaggacc ggctgggcga cggtcgtgga ccccgacggc cgggatgccg
     9001 tggagcgctc cctgatcgcc gccaccggtc ccgagggtca ggcccccgtc ccctcgatac
     9061 gcgcggcgca cgccacctcc gacggcgtcc gcgcgctggc gcagcggctc accgacgcgg
     9121 ggctcgcggt gcccacggcg gcccgggagt cgatctccgc cgccatccgc gaggtccgcg
     9181 cggccgccgc cctcgtcctg gtcatgcccg cggccgcgac gaccctcagc cccgccgacc
     9241 ggtcggtgct gccgtggttc gcgctccccc tgccggccgc cctcggctgc ctggccgtcg
     9301 cgcgcttcga gatccacgcg tacacccgct gggccgcgcc cgcgggccgg gacctgctgc
     9361 gcgccgtcga cgtcccccac ggcccggccc ccgacgacag ccggcagatc ctcaccgcgc
     9421 tcgccgtccg gggcccctcc accctccccg atcccgcact ccgcgcggcc ctgagctgac
     9481 gcgccgcgcg gggccgggcg tcaggccaga cccgccagca gcttgcggcg gccggtgggg
     9541 aagggcgcct catcgcggac gggcacacgc gcctccaaag cccgcagatg acgcatcagg
     9601 tccaccgata cggtgcagtt cgcccgcacg tcggggtcgc cccacgccag cttgccgcgg
     9661 cagaacctcc ttgcgcccgc ccccgcgctg ctcggccccg gagggcctcc caggcttcga
     9721 ccggcccgcc ggactccgtc cggaacgcgc caccccggga cagcccccgc ggggcagggc
     9781 gtcaggccag gcccgccacc agatccgcca ccgacttgcg gcggccggtg tagaacggca
     9841 cctcctcgcg gacgtgcata cgcgcctccg aagcccgcag gtgacgcatc aggtccacga
     9901 tgcggtgcag ttcgtccgac tcgaaggcca ggatccactc gtagtcgccc agcgagaacg
     9961 acgccaccgt gttcgcccgc acgtccgggt aaccccgcgc catcttgccg tggtcggcca
    10021 gcatgcggcg gcggtcctcg tcgggcagga ggtaccagtc gtaggagcgg acgaaggggt
    10081 agacggagac gtagtcgcgg gccgtctcgt cggcgaggaa ggcggggatg tggctcttgt
    10141 tgaactccgc cgggcggtgc agtgccatgt tcgaccacac gggctccagc cggcgcccca
    10201 gcagggtgcg gcggaagcgg ttgtaggcgt cctggagggc gtccgcggtc tcggagtgcc
    10261 accagatcat gacgtccgcg tcggcgcgca gcccggacag gtcgtacgtg ccgcggaccg
    10321 tgacgtcctt ctcggcgagc tgcgcgaaga gctcctccac ctcctccgcg tagcggatgc
    10381 ggtcgtcggg gaggacgtcg cgcagccgga acaccgacca gagggtgtag cggatgacct
    10441 cgttgaggtc cttggccttc ttgccggcgt tgggggcctt ggcgggggcg gcggaagcag
    10501 tggagtcggt catggggcta ttgtcccgcg ccgggttccg cggcccgccg cagggtgccc
    10561 aggacctgcg tggccgcgcc gcgcgcgctc gaaacgcagg ccgggatgcc cacgccctcg
    10621 tacagggcgc cgcacatctc gaggccgggc agcttcgcga cgtgctcgcg cagccgcgtg
    10681 acccgggcca ggtggccgac cgggtactgc ggcaggccgc cgtcccagcg ggtgacacgg
    10741 gccgcgacgg gggccgcggt gagtccgacg gcctcgccga ggtcctcgcg ggagaggcgg
    10801 acgagatcgg tgtcgtccca ggcgaggtcg gcctcctggc cgtgccgccc gatcgaggtg
    10861 cgcagcacgt agacgtcgga gtcggcggcg ccgctccagt gccacttctg gctggagaac
    10921 gtggacgcct tgatggtgcg cccgtccacc ggggggacga ggaagccgct gccgggcagc
    10981 gcgtgggcga tctcgcggcg ccggaaggcc atggtgacca gggcgacgct cgcgtactcc
    11041 accgccgaca gctccgtggc ggcgcccggc gactcggcgg ccagcagcct ggccgcggcc
    11101 ggggcgggca cggccagcac gaccgcgtcc gcggccagcg tctcgcgggt gccgtcgtgg
    11161 tcgaaggcga cctcccagcc gtcgggggtg cggcgcagcg tccggaccgg ggcgtcggtc
    11221 tcgatgcggg ccccggcgga gcggcaggcc tcggcgacgg cgaccgggag ccgcccgacg
    11281 ccgccgcgga tgccggcgaa gaccgggccg tcctgccggg cggcggcggc cttgcgctgg
    11341 ctctcgcgga cggtctcgat cagggagcgg ccgccgcgcg cgccct
//
