LOCUS       NZ_LT906439            22490 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Streptococcus merionis strain NCTC13788 chromosome 1, complete
            sequence.
ACCESSION   NZ_LT906439
VERSION     NZ_LT906439.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus merionis
  ORGANISM  Streptococcus merionis
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JUN-2017) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900187085.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 13:40:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,228
            CDSs (total)                      :: 2,160
            Genes (coding)                    :: 2,111
            CDSs (with protein)               :: 2,111
            Genes (RNA)                       :: 68
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 27 of 49
            Pseudo Genes (incomplete)         :: 28 of 49
            Pseudo Genes (internal stop)      :: 10 of 49
            Pseudo Genes (multiple problems)  :: 16 of 49
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:09:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1197810
            Orig. end                         :: 1220300
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT906439.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22490
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="6"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22490
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22490
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12490](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12490)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            complement(166..501)
                     /locus_tag="CKV83_RS05530"
                     /old_locus_tag="SAMEA4412692_01108"
     CDS             complement(166..501)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373443.1"
                     /locus_tag="CKV83_RS05530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01108"
                     /product="MazG nucleotide pyrophosphohydrolase
                     domain-containing protein"
                     /protein_id="WP_018373443.1"
                     /transl_table=11
                     /translation="MNITIPQLQAYLAQHYQGDQDEQGFFMKLVEEVGEVAEVLNQRAG
                     RKVQDKADLDLELVTELADILHYTVAIAAVNGLDLNRIILEKDKRAAVKYQHEMDLETF
                     LKAQRKS"
     gene            complement(644..1165)
                     /locus_tag="CKV83_RS05535"
                     /old_locus_tag="SAMEA4412692_01109"
     CDS             complement(644..1165)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.5"
                     /locus_tag="CKV83_RS05535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01109"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_018373444.1"
                     /transl_table=11
                     /translation="MKKWIIRDAELLVNPDNKREAVRGLLLTEDRSQMLLLYYRKHHFY
                     TLPGGGLEPDEDAVTAFWREVKEETGFDCDCLQELGIVEEHRTFVSTVQVNYIYFAQVS
                     SKQSAKQLDEKENLDGLELEILPIFEAYQKVFEQATSTEQQRFLSQRDKIVLQEGLKMI
                     GQSGLLLEER"
     gene            complement(1219..1722)
                     /locus_tag="CKV83_RS05540"
                     /old_locus_tag="SAMEA4412692_01110"
     CDS             complement(1219..1722)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024952.5"
                     /locus_tag="CKV83_RS05540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01110"
                     /product="2'-5' RNA ligase family protein"
                     /protein_id="WP_018373445.1"
                     /transl_table=11
                     /translation="MEVRHFWRELEDAKISNYASRVSNRCPHLTLGSYNHLTDRADFIQ
                     RLHDFCQGQSAIVLTLPLLSSFAQSGALLLTPQVNRELLNFHQDLHATLAQFDSDRVSF
                     YQPQSWIPHVTLANYLTARDLMAAFGYCEKRLDPLRGRITGVSLLEIFEDKQVVKVCEF
                     DLKA"
     gene            complement(1760..2230)
                     /locus_tag="CKV83_RS05545"
                     /old_locus_tag="SAMEA4412692_01111"
     CDS             complement(1760..2230)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004186788.1"
                     /locus_tag="CKV83_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01111"
                     /product="8-oxo-dGTP diphosphatase"
                     /protein_id="WP_018373446.1"
                     /transl_table=11
                     /translation="MVFLATICYVDNGESLLLLHRNKKPNDVHKGKWIGVGGKFETGES
                     PEDCAKREILEETGLLATEMKLAGVITFPEFTPDNDWYTYVFRVTGFEGQLIEDCPEGE
                     LAWISYDQVLQQPTWEGDKTFLGWILDNKPFFSAKFSYKDNELVSEEVTFYE"
     gene            complement(2315..2968)
                     /locus_tag="CKV83_RS05550"
                     /old_locus_tag="SAMEA4412692_01112"
     CDS             complement(2315..2968)
                     /EC_number="3.2.2.27"
                     /GO_function="GO:0004844 - uracil DNA N-glycosylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006284 - base-excision repair [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001841111.1"
                     /locus_tag="CKV83_RS05550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01112"
                     /product="uracil-DNA glycosylase"
                     /protein_id="WP_018373447.1"
                     /transl_table=11
                     /translation="MQHSAWHELIKAKLPDHYFGRINAFLDQVYSEGLVYPPREKVFAA
                     VQHTALQDVKVVILGQDPYHGPDQAQGLSFSVPDTIPAPPSLQNILKELSDDIGVKSSH
                     DLTSWGDQGVLLLNACLTVPAGQANGHAGRIWEPFTDAVISVVNDLETPVVFILWGAYA
                     RKKKGLITNRHHLILESAHPSPLSSHRGFFGSRPFSKANAFLAENGRAEIDWLR"
     gene            complement(2981..3679)
                     /locus_tag="CKV83_RS05555"
                     /old_locus_tag="SAMEA4412692_01113"
     CDS             complement(2981..3679)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003076949.1"
                     /locus_tag="CKV83_RS05555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01113"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_018373448.1"
                     /transl_table=11
                     /translation="MLPAYIQIHNQIKEEIDQGIWKIGQRLPSERDFADRFQVSRMTLR
                     QAMTLLVEEGVLERKVGSGTYVAGNRIQEKMRGTTSFTEIIKSQGKQPSTQLISYLSGK
                     PNKKEQAHLELRPMESVVRMERVRFADDVPVVYEVAVVPKKFIARISEEEVTQHFFKAL
                     TEAGYKIGKSQQTIYARLAQGIVTDYLGVEPGQAILGLTQVSYFEDGQPFEYVKSQYAG
                     ERFEFYLENN"
     gene            3799..5361
                     /gene="guaA"
                     /locus_tag="CKV83_RS05560"
                     /old_locus_tag="SAMEA4412692_01114"
     CDS             3799..5361
                     /EC_number="6.3.5.2"
                     /GO_function="GO:0003922 - GMP synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016462 - pyrophosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006177 - GMP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="guaA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373449.1"
                     /locus_tag="CKV83_RS05560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01114"
                     /product="glutamine-hydrolyzing GMP synthase"
                     /protein_id="WP_018373449.1"
                     /transl_table=11
                     /translation="MTSIAKDFTDVEKIIVLDYGSQYNQLITRRIREFGVFSELKSHKL
                     SAEEIRAINPIGIVLSGGPNSVYAENSFGIDEEIFELGIPILGICYGMQLLTDRLGGKV
                     VPAGEAGNREYGQSELTQTGSALFANTPEKQVVLMSHGDAVTEIPAGFVRTGQSADCPF
                     AAIENTDKQIFGIQFHPEVRHSEYGNDILRNFAINICGAKADWSMDNFIDMEIEKIRAT
                     VGDKKVLLGLSGGVDSSVVGVLLQRAIGDQLTCIFVDHGLLRKGEADQVMEMLGGKFGL
                     NIIKADAAKRFLDKLAGIADPEQKRKIIGNEFVYVFDDEASKLQDVKFLAQGTLYTDII
                     ESGTETAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRALGTALGMPDDIVWRQPFP
                     GPGLAIRVMGEITEEKLETVRESDAILREEIAKAGLDRDIWQYFTVNTGVRSVGVMGDG
                     RTYDYTIAIRAITSIDGMTADFAKIPWEVLQKISVRIVNEVDHVNRIVYDITSKPPATV
                     EWE"
     gene            complement(5782..7557)
                     /locus_tag="CKV83_RS05565"
                     /old_locus_tag="SAMEA4412692_01115"
     CDS             complement(5782..7557)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.5"
                     /locus_tag="CKV83_RS05565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01115"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_018373450.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.6e-28, bitscore:
                     96.1, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKITNKFIRLSILVIGLICITSSETVTADSNVLMQEEVAGTTYSL
                     ANIKPDSFDEISYNHSMNVELPQSLDRGTSNFLEEITEIKNFSTESVPTIDDNLNYLEG
                     EAGNKNGVAEQTDRSSDRHAVSSKVDIAISSTEVEKLNTTDEFNKTDKVTLRLFNKSNS
                     EGQESEEQNLWKYQWDMQRLTDNGRYYKHYWPLDDIRVAVIDSGISYEHAELVKYLGSN
                     SKDLVHNKVDEHAFQDNIGHGTSVVSLIVSNDYIKGIIPGATYNMYKSIDLDINDDQLT
                     IDAIKQAADDGNQIINISLGRYLMISGQYEDGTNDYPLYLKYKQAVDYATLKGSIIVAS
                     MGNDSLNLLDNNQLLEFLSRTKKIREPGQIVDVPAYFDNVISVGGIDRFDNLSNFSNYG
                     YNAIYTYAGSTEFLYSVTDLDLLRKKIAENWILTAQKTGFSYLFGNSLATPKVSGAIAL
                     LVSKYKTSNFNVIKSYLIDKTIQKDGLAILNLENIIFSDEIISLNFNKIEHSEFINSIY
                     SNTVIVEKIEYNPDMQKDYYVNYEKELSMEIRFLPKTNSSDFPSYTISLAGLIIIISVI
                     ITTSPMNRIYKREVE"
     gene            complement(7541..7897)
                     /locus_tag="CKV83_RS05570"
                     /old_locus_tag="SAMEA4412692_01116"
     CDS             complement(7541..7897)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CKV83_RS05570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMEA4412692_01116"
                     /product="hypothetical protein"
                     /protein_id="WP_018373451.1"
                     /transl_table=11
                     /translation="MIENILKNILVNNILIILLITIFTLSFLKVVIDKIQQSNLHIVIT
                     TNNINIKFTSFIVSKFIVALLLLLNITLISFLVFPHIKLVLISQVLVKVLILVFYITMF
                     LLFIKKEFLNENHK"
     gene            complement(7894..9498)
                     /locus_tag="CKV83_RS05575"
                     /old_locus_tag="SAMEA4412692_01117"
     CDS             complement(7894..9498)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="CKV83_RS05575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01117"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_018373452.1"
                     /transl_table=11
                     /translation="MKIVYKYIGNQRLVFSIYNIIVFISFILELLFPLLTGQFLNQLVS
                     HDLNNLKTTIFYMFLVGLLNQLLQFINKFLAIHFSEKVSQTVRIDILNILRKLNYNEIT
                     KIKASELTQRVNLDLGQITTFLLDNFIIYFLRIIQTAMILIYLLREQYLIFLVFVMVTF
                     FYVNIYIYFRKKIFDASNSLKNSTSIYYNQFHYQVDNLSYIIHKANYYLENKRFNNSFN
                     LYFASLDRFTKINSKFRFLQSILSLLLNVVMFSIVAFYVMRDNLEIGIVNVSLSYFSII
                     LSNIEYFFDFGGNLQAFKASIQNIEGFWLLSTDREGNIELHKKIHSISGSITRAYDKSY
                     PPLSFDISNNGLWSIIGENGSGKSTFYKLITGILKDKGNIINVDGYSITDLNTVFLRRN
                     NFTIVEQKFPIFDLTVQDFFTMNTSCATVDDILYLLHDKNIDTDIINEVLVTKWSEVDS
                     SLSGGELQVLRIIESFLSNVNVKIYDEPTSNLDKVYTDWFIESVKQLKRDNIIIIITHD
                     PAIIASSDRIITVGGIS"
     gene            complement(9754..9918)
                     /locus_tag="CKV83_RS11410"
                     /old_locus_tag="SAMEA4412692_01118"
     CDS             complement(9754..9918)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CKV83_RS11410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMEA4412692_01118"
                     /product="hypothetical protein"
                     /protein_id="WP_156809068.1"
                     /transl_table=11
                     /translation="MSKNIPQVTSVLDLQKLPVSGATQGIDPRFPTTVTFTVTTVTGFW
                     STQSVRCKG"
     CDS_motif       complement(9838..9918)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSKNIPQVTSVLDLQKLPVSGATQGID"
                     /locus_tag="CKV83_RS11410_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9754..9837)
                     /prepeptide="core"
                     /locus_tag="CKV83_RS11410_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-1.10"
                     /molecular_weight="2825.2"
                     /monoisotopic_mass="2823.5"
                     /core_sequence="PRFPTTVTFTVTTVTGFWSTQSVRCKG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSKNIPQVTSVLDLQKLPVSGATQGID"
                     /leader_location="[9837:9918](-)"
                     /alternative_weights="2843.2"
                     /alternative_weights="2861.2"
                     /alternative_weights="2879.3"
                     /alternative_weights="2897.3"
                     /alternative_weights="2915.3"
                     /alternative_weights="2933.3"
                     /alternative_weights="2951.3"
                     /alternative_weights="2969.4"
                     /alternative_weights="2987.4"
     gene            complement(10001..12490)
                     /gene="lanKC"
                     /locus_tag="CKV83_RS05580"
                     /old_locus_tag="SAMEA4412692_01119"
     CDS             complement(10001..12490)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="CKV83_RS05580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01119"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_145955184.1"
                     /sec_met_domain="Pkinase (E-value: 4.3e-16, bitscore: 56.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.7e-15, bitscore:
                     51.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENSRYLVADDDFFVDSLNNINVTEIFELLNIPKDYDCIISENKF
                     WVYYTSKADELPLQGWKLHISVKYEESEEVLREVASYLFENRISFKHIYSKIDLLDTLS
                     KNGNRLLSGKFITIYPQEDMLATVLENLYNILKKFTKACYVLTDRRYKDSNIFFRYGAF
                     QRIENQGELCILDPEGNYYPDKREPFFDIPNFVNIPKCLEESINSVHSEVLENQDRFND
                     YIFLKSLKYTTSGGIYVAKKRSSDRKVVIKEGRSSTGFDSQKKSIIERLKSEYNVLERL
                     KDNEYVVNSIEAFEYWENYYLVEEFITGITLTQWCTINFEYTSETDKTDYILKVRRIAN
                     ELEYILSTIHEDGIGLSDLQPSNIMINDDLECRLIDFETAGDVNEKYSGLATYGFSNND
                     CTRKENDKKSLKKIIRYLLLPIAPIDNFDNRQHNIQDSYINHIYGKEIIRKYFSDYVGI
                     HDRELFNYDLEDIERRLVSGIVNNVIQEDIFSYGELDAYLDSYGKINYLTGGLGMLYAL
                     HMGGANVHSYKNWIISQKDLIKKCDLGLLTGRTGIINVLYSIGEIEIADDLSRSLLEEL
                     DSFEVTSDLSLKSGVSGIVLGLLSIGNYNSEIHESIRIKTENLFIKHKFYIEEEIKKFD
                     NLDLLTGVSGIALMLLVLFSETGNQSYYEIAILILNKMEMKLIEDVPTGVIQLTVSENR
                     LMPYLESGSVGVSLVWYYLKYILNDNSFDEKLKKIKNNLKLITFYDGNFLSGAFGQILL
                     LAILEEKDVPKEIMLLLNLYLVNRGETLVLPGRGAVRLSLDILTGNSGAILAIEAWKRQ
                     NPFLWLPILIKGVFKMY"
     misc_feature    12558..12574
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.92"
                     /tool="antismash"
     misc_feature    12619..12633
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.42"
                     /tool="antismash"
     gene            complement(12787..12951)
                     /locus_tag="CKV83_RS11710"
     CDS             complement(12787..12951)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040904.1"
                     /locus_tag="CKV83_RS11710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PhrA family quorum-sensing system peptide"
                     /protein_id="WP_095114566.1"
                     /transl_table=11
                     /translation="MKKNTIIKSLACLLLGYTLLCDTVHYQQLFNNTRFDVQIQPTKKT
                     NGLDVGKAD"
     gene            13146..14009
                     /locus_tag="CKV83_RS05590"
                     /old_locus_tag="SAMEA4412692_01120"
     CDS             13146..14009
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373454.1"
                     /locus_tag="CKV83_RS05590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01120"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_018373454.1"
                     /transl_table=11
                     /translation="MNMVAEKFRLKRKELGLSQKVLSEGICEQSQISKIERGNFMPSAD
                     LLFKLSQRLDVPLDYFFNEQIEVPSNLSNFKHLSSRLLDDRNYDDLEYLYKVETDRNTF
                     LSSEDRMYLEWVKLIIDFYKYDLKDKAISSLESMLSKISPKTQVYLKVLNTLSNFYSLV
                     GREQDYESNYSLLMKIYQTKNLDHQEFLFGYIRVRYNYAHYLVFKEKYNEAIQEALETI
                     EFCKSKQTSYQLAPLLILVGNSGEQFLDKEQVKNYYLEARELCKIYGNPLMLMKIENYL
                     KELDNN"
     gene            complement(14130..14600)
                     /locus_tag="CKV83_RS05595"
                     /old_locus_tag="SAMEA4412692_01121"
     CDS             complement(14130..14600)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373455.1"
                     /locus_tag="CKV83_RS05595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01121"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_018373455.1"
                     /transl_table=11
                     /translation="MEEVHLIRIAISDAEKLLLLQKEAFKDLLDKYHDFETNPGNESLE
                     KIEAKLKQKETYFYYICADSAIVGAVRVVDRKDGSRKRVAPIFIMKDYRGKGFAQKAFY
                     QIEKIHGQNHWKLDTILQEAGNCYLYEKLGYQKTGEIETINEKMDIVYFEKD"
     gene            14872..15486
                     /locus_tag="CKV83_RS05600"
                     /old_locus_tag="SAMEA4412692_01122"
     CDS             14872..15486
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373456.1"
                     /locus_tag="CKV83_RS05600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01122"
                     /product="hypothetical protein"
                     /protein_id="WP_018373456.1"
                     /transl_table=11
                     /translation="MLLSLQGSMAVGKSTAIDYIQQHAPDIRILPEDNRDIIQKLRLLD
                     LDKTQFEDYVTIQRYWIAHEIERYQLAKDSLYTLVDWGAEEMAYYTLHFPKSIGKDWDI
                     ATALAPELTALKACFPERTLFLQTGQETLQERKDSDRTRRRNFFNHYTQHLLPGKLAWL
                     QTQLPVDVLAVDQLSSDQVGQAVLAWCQKHFGLNNQSDQVF"
     gene            15568..16791
                     /gene="pepT"
                     /locus_tag="CKV83_RS05605"
                     /old_locus_tag="SAMEA4412692_01123"
     CDS             15568..16791
                     /EC_number="3.4.11.4"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0045148 - tripeptide aminopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="pepT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000222047.1"
                     /locus_tag="CKV83_RS05605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01123"
                     /product="peptidase T"
                     /protein_id="WP_018373457.1"
                     /transl_table=11
                     /translation="MTYPHLLERFLTYVKVNTRSDETSTTTPSTQSQVDFAHNVLLPEM
                     KRVGLQDVHYLPNGFAIGTLPANDTSLTRKIGFIAHMDTADFNAENVSPQVIENYDGST
                     IALGSSGYELNPKDFPQLTNYHGQTLITTDGTTLLGADDKSGIAEIMTAIEFLVENPDI
                     KHCEIRVGFGPDEEIGVGADKFDVEDFNVDFAYTVDGGPLGELQYDTFSAAEAHLEFIG
                     RNVHPGTAKGSMINALQLAIDFHNQLPADDRPELTEGHEGFFHLMKMEGTVDHATSSYI
                     IRDFEDQDFQNRKALMQSIADQMNANLDTERVVLNMHDQYYNMKKIIEKDMTPINIAKA
                     VMETQGIEPLIEPVRGGTDGSKISFMGIPTPNLFAGGENMHGRFEFVSLQTMEKAVDVI
                     IGIVSYND"
     gene            16906..17568
                     /locus_tag="CKV83_RS05610"
                     /old_locus_tag="SAMEA4412692_01124"
     CDS             16906..17568
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012657988.1"
                     /locus_tag="CKV83_RS05610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01124"
                     /product="DNA alkylation repair protein"
                     /protein_id="WP_026216926.1"
                     /transl_table=11
                     /translation="MKTQKSCEILLSRFENARNLTKAQSMSAYMRHQFDFYGIPTPERR
                     KIYKDIISKAKESEMIDWDLLDIMWNQPKRECHYFVCDYLVAVTAHLTIADLPKLMYFA
                     QTQQWWDTIDHLDYVFGHIADEKMPEILLAMSLSDDFWLRRIAIDHQLGKKEQTDTELL
                     QNIILNNLGSQEFFINKAIGWSLRDYSKTNPDWVRNFIDQHHEKMAPLSIREATKYL"
     gene            complement(17628..18947)
                     /locus_tag="CKV83_RS05615"
                     /old_locus_tag="SAMEA4412692_01125"
     CDS             complement(17628..18947)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373459.1"
                     /locus_tag="CKV83_RS05615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01125"
                     /product="uracil-xanthine permease family protein"
                     /protein_id="WP_018373459.1"
                     /transl_table=11
                     /translation="MESSTSRVNLLLDVDQNPPFAKGLLLSIQHVFAMFGATILVPLIL
                     GMPVSVALFASGLGTLIYMVATQFRVPVYLGSSFAYISAMAFAIEQMGGDIKAAQTGVI
                     LVGLIYVIVAAMVRVLGTRWIDRILPPIVIGPMIMVIGLGLAGSAVTNAGFVANGNVKN
                     IIVAIVTFLITAFINTKAKGFLKIIPFLFGIIGGYIVAIFFGLVDFTPVLEANWFELPG
                     FYLPFETGGLFNTYDLYFGPETWAILPVAVVTIAEHIGDHTVLSEICGRQFLKSPGLHR
                     TLIGDGVATAVSAFMGGPANTTYGENTGVIGMTRIASVSVIRNAAVIALGLSFFGKFTA
                     LISTIPNAVLGGMAILLYGVIASNGLKVMIEKRVDFRQVRNLIIASSMLVLGLGGAILE
                     IGAVTLSGTALSAIAGILLNLILPHEEAFDDHKVEELLEN"
     misc_feature    19020..19032
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.49"
                     /tool="antismash"
     misc_feature    complement(19065..19081)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 23.99"
                     /tool="antismash"
     gene            complement(19356..21572)
                     /locus_tag="CKV83_RS05620"
                     /old_locus_tag="SAMEA4412692_01126"
     CDS             complement(19356..21572)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01363.1"
                     /locus_tag="CKV83_RS05620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_01126"
                     /product="pneumococcal-type histidine triad protein"
                     /protein_id="WP_018373461.1"
                     /transl_table=11
                     /translation="MNKKKLLISSAVLSLCLASSAGAYYLGHQQGQDEAGSNQVSYVDA
                     SGKDSKVVTNTKGMTPDEVSAKEGISAEQIVIKITDDGYVTAHGDHFHYYTGKVPYDAI
                     LSEELIMKDPNYVFKQSDVINEVKDGYIIKVEGKYYLYLKEGSKSENIRSKAEVAEQQA
                     RASKKSGHRENGGTLSSVSTSGRYTTDDGYVFSPTDVIDDLGDAFIVPHGDHFHYIPKA
                     DLSASELAAAQEYWDKKVGKGNPVRPPYANAQGQMNQSIHYQPANPDGTPNLIQSGTNS
                     VNQAVQPGETLAGLLAQLDRTPLSERHVEVDGLVYDPRTITRFSSTGVAVPHGNHYHFI
                     PYSSMSALELKITKLLAAGHPIDDKSIIAPTQPTQPKPKQPIQPIVKPSKPEKPIVKPA
                     KPNVPTPPSPDKPKDDHGVTPLNERKGKPNSQIVYSPEEIAKAKAAGKYTTSDGYIFDA
                     KDIIDDMGDAYLTPHMGHTHWIPKKNLSAEELAAAEAFWKAKKGEQSEVPAVPETPENP
                     SDGSRKKSTPEIYETVKAAKIVPVDKIPYRADQAVAYRNGMLIIPHHDHYHNLDLNYFD
                     GPRAIYEAPEGYTIEELMATIKYYVENPSERPLKEGWGNDSDHDKPGNKEDNNYDINEE
                     PEEDTEDEVDDHTLKMQKLAKQYHMDQKEFEKRIGTLCFRYWASEDNLEFINETEVRIT
                     KPDGTIVLVNLHTMEEVVTEPSDSATSELSVADSVITQAEESLE"
     misc_feature    22186..22197
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.75"
                     /tool="antismash"
ORIGIN
        1 agccctgtag cgtctataac atcagcacct tctctgacga tttcatggcc catctgaaca
       61 atctgcctat cttgaaccaa aatatccatt ttctgatcca gacccgattt cggatcaacc
      121 acacgaccat tcttaattaa aagcatttat tcaccactgt tctttctagg acttcctttg
      181 agctttgaga aaagtctcca aatccatctc atgctggtac ttgacagcag ctcgcttatc
      241 cttttcaagg ataatccgat tgagatcaag gccattaact gccgcaatcg ccactgtgta
      301 atgcaaaata tccgctaact ctgtcaccag ctccaagtcc aaatcagcct tatcttgaac
      361 cttgcgccct gctcgctgat tgaggacttc agccacttcg ccaacctcct ctaccaactt
      421 cataaaaaag ccctgctcat cttgatcacc ctgataatgc tgagctaagt atgcttgtaa
      481 ctgtgggata gtgatattca tgttagcctc ctttgaatta aaacataaag cctgttagaa
      541 aaagcgtagg agcagggaaa attaatgatg agcgcagaca ctctggaaaa ttttagagtg
      601 ttttctggct tttttaggac gtgttcaatt aaagtgcttc tttctatcgc tcttccaaca
      661 gcaatcctga ctgaccgatc atttttaaac cttcttgcag tactatctta tcccgctgag
      721 ataaaaagcg ttgttgctct gtagaagtag cttgctcaaa cactttttga taggcttcaa
      781 agattggcag aatttcgagt tcaagtccat ccaaattttc tttttcatct aattgtttag
      841 ctgattgctt acttgagact tgagcaaagt agatataatt gacttgaaca gttgacacaa
      901 aggtccgatg ttcctcaaca atccctaatt cctgtaaaca gtcacaatca aaccctgttt
      961 cttctttaac ttcccgccaa aaagctgtca ccgcatcttc atcaggctct aatcctccac
     1021 caggcaaagt gtaaaaatgg tgtttccgat aatataacag taacatctga cttctatcct
     1081 ctgttaatag cagtccacga acagcctcac gtttgttatc aggattgacc aataactctg
     1141 catctctgat gatccatttt ttcatctttt cgattcttcc tccgctgcac actagctttt
     1201 ttgaatatgt catctacact aagctttcag gtcaaactca caaaccttta caacctgctt
     1261 gtcctcaaaa atctctagta atgatactcc tgttatccgt cctcttagag gatctagtct
     1321 tttttcgcaa tagccaaagg ctgccatcaa gtcacgcgct gtcagatagt tcgccaaagt
     1381 tacatgagga atccagctct ggggctggta gaaagacacc ctgtcgctat caaactgcgc
     1441 cagcgtcgca tgcaagtctt gatgaaaatt cagtaactcc cgattgactt gcggtgtcaa
     1501 aagcagagct cctgactgag caaaagaact gaggagtggt aaagttaaga ctatcgcaga
     1561 ttgcccttga cagaaatcat gcaacctctg gataaaatca gctctatcgg ttaaatgatt
     1621 gtaacttccc aaggtcaaat gaggacagcg attagaaacc ctgctggcat agttagaaat
     1681 ctttgcatct tccagctctc gccagaaatg acgcacttcc atatccagat cttaatcaaa
     1741 aaaggcaact accgcaaact cactcataaa aggtaacctc ctcactcacc aattcattat
     1801 ccttgtagga aaatttggct gaaaagaacg gcttattatc caaaatccag ccgagaaagg
     1861 tcttgtcacc ctcccaagtt ggctgctgca agacttggtc ataggaaatc caagccagtt
     1921 ctccctcagg gcagtcctcg atcaattgac cttcaaaacc cgtcactcga aaaacgtagg
     1981 tataccaatc attatctggc gtaaattcag gaaaggtaat cacgcccgcc aacttcatct
     2041 ctgttgccaa aagccccgtt tcttctaaaa tctcgcgttt cgcacagtct tctggactct
     2101 ctcctgtttc aaatttgcca ccaacaccaa tccatttgcc cttatggaca tcatttggct
     2161 tcttattacg atgaaggagc aagagagact ctccattatc cacatagcaa atcgtcgcta
     2221 aaaataccat ttcatctcct ccagtccata ctataacaaa agtgccgata gaacagctga
     2281 gctaacgacc ttaaatttta atttttgaca agttttagcg taaccaatca atctccgctc
     2341 tgccattttc cgccaaaaat gcattagcct ttgaaaaggg acggctacca aaaaagccac
     2401 gatgactaga caaggggcta ggatgagccg actctaatat caagtggtgt ctattagtga
     2461 tgaggccttt tttcttgcgg gcataggcac cccaaaggat gaaaactaca ggagtttcca
     2521 gatcattgac cacactgatg acagcgtctg taaagggctc ccaaatgcga ccagcatgtc
     2581 cattggcttg gccagcagga acagtcagac aagcgttcaa caaaagaact ccctgatctc
     2641 cccatgaggt caaatcgtga gaacttttga caccaatatc atcactcagt tccttgagga
     2701 tattttgtaa agatggcggt gcaggaatgg tgtctggaac cgaaaaagat aggccctggg
     2761 cttgatctgg gccgtgatat ggatcttgtc ccaagataac taccttgacg tcctgaaggg
     2821 cagtgtgttg aactgccgca aagaccttct cacgtggtgg gtagaccagt ccctcagaat
     2881 aaacctgatc taaaaaggca ttgatccttc caaaataatg gtctggcaat ttagccttga
     2941 tcaactcgtg ccaagcagaa tgttgcatgg taaaatctcc ttaattattt tctaagtaaa
     3001 actcaaatcg ctcccctgca tactgacttt tcacatactc aaagggctga ccgtcttcaa
     3061 agtatgacac ctgagtaagg cctaaaatgg cctgccccgg ctccacaccc agatagtctg
     3121 tgacaatgcc ctgagctaga cgagcataga tagtctgctg actcttgcca attttgtagc
     3181 cagcctcggt caatgctttg aagaaatgct gcgtcacttc ctcctcagaa atccgagcaa
     3241 taaacttctt aggcactaca gccacttcat aaaccacagg aacatcatca gcaaaccgca
     3301 cccgctccat acgcacgacg ctctccattg ggcgtaactc cagatgagcc tgctctttct
     3361 tattgggttt gccactgaga taggaaatca actgggttga aggctgcttg ccctgagact
     3421 tgataatttc cgtgaaagat gtcgtccctc tcatcttttc ttgaatccga ttgccagcta
     3481 cataagttcc agatccgact ttacgctcca agaccccttc ttcaacaagc aatgtcatcg
     3541 cctgacggag agtcattcgg ctgacttgaa aacgatccgc aaaatcacgc tcacttggta
     3601 gcctctggcc gattttccag atgccttggt caatttcttc cttaatttga ttatgaattt
     3661 gtatatatgc tggtaacata agcacctctt tcacactaat cttatcaaat ttctaacaat
     3721 aaatccattt taccatagaa aattccggtt tttgtggtag aatagggata tcatattgct
     3781 ttttgagaaa ggaaagacat gactagcatt gcaaaagact tcacagacgt ggaaaaaatc
     3841 atcgtcttgg actacggtag ccagtacaat cagctcatta cgcgccgtat ccgtgagttc
     3901 ggtgttttct cagaactcaa gagccataag ctctctgctg aggaaatccg cgccattaac
     3961 cctatcggta tcgtcttgtc cggtggtcct aattccgttt acgctgagaa ctccttcggt
     4021 attgacgaag aaatctttga gcttggcatt cctatcttgg ggatttgcta cggcatgcaa
     4081 ctcctgacag accgtctcgg aggtaaggtc gttcctgctg gtgaagctgg taaccgcgag
     4141 tacggtcaat ctgaactgac ccaaacaggc tcagctctct ttgctaatac acctgaaaaa
     4201 caggtcgtgc ttatgagcca tggcgatgca gtcactgaaa ttccagcagg ctttgttcgc
     4261 accggtcaat ccgctgactg tccttttgcg gctattgaaa atactgacaa acaaattttc
     4321 ggtatccaat tccaccctga agttcgccat tcagagtacg gcaatgatat cttgcgcaac
     4381 tttgctatca acatctgtgg cgctaaggct gactggtcaa tggataattt cattgatatg
     4441 gaaattgaaa aaatccgcgc gactgtcggt gataaaaaag ttcttttagg actatctggc
     4501 ggagtagatt cgtctgtcgt tggggtcctc cttcagcgcg cgattggtga ccaattgact
     4561 tgtatctttg tcgatcatgg cttactccgc aaaggcgagg cagatcaggt catggaaatg
     4621 ttgggtggta aatttggtct taatatcatc aaagctgacg ctgcaaaacg cttccttgac
     4681 aaattagcag gcattgctga cccagagcaa aaacgcaaaa ttatcggtaa cgaatttgtc
     4741 tacgtctttg acgacgaagc cagcaagctc caagacgtga aattcttagc tcagggaact
     4801 ctctataccg acatcatcga atctggaacg gagaccgcac agaccattaa gtctcatcac
     4861 aatgtcggtg ggctaccaga ggacatgcaa ttcaaactca tcgagccgct caataccctt
     4921 ttcaaagatg aagttcgcgc acttggtact gctctaggca tgcctgatga cattgtttgg
     4981 cggcaaccat tcccagggcc aggtcttgct atccgcgtga tgggtgaaat caccgaagaa
     5041 aaattagaaa cggtgcgtga gtccgatgcc atcctccgcg aggaaatcgc taaagctggt
     5101 cttgaccgcg atatctggca atactttact gtcaacacag gtgtccgttc tgtcggtgtt
     5161 atgggcgatg gcagaaccta cgactacacc atcgctatcc gtgccatcac ttccattgac
     5221 ggcatgaccg cagactttgc caagattccg tgggaagttc tccagaaaat ctctgtccgt
     5281 atcgtcaatg aagttgacca cgtcaaccgt atcgtctatg acatcaccag caaaccacca
     5341 gcaacggttg agtgggaata gagtttataa tagttagagt tcttaaaaag ttaatttaac
     5401 agcttttgaa gctatttaaa aaattaaaaa ataccaacta aataattgat tcactactaa
     5461 atccccacca gaagattcat ctgatgggga ttttttacat aatcattagt caatcaaggt
     5521 aaccgcccac tcaactaaat aaaattttac gatgcatagt ctatagaaat agtcataata
     5581 caacaatatt gagaaaaata aaaagctata aatcaatttc tagtactcat tctattattg
     5641 attaaaccta taatagcaag ttactttcag aatagagtaa agaaactaaa ttaaagtaac
     5701 aacaattgta tattatttta gattccgaat attttctaaa ataatcaatt atctagttga
     5761 aaatatacaa tattcattca gttactctac ttccctttta taaatacgat tcattggact
     5821 cgttgtaata atcactgaga taataataat caatcctgct aacgaaattg tatatgatgg
     5881 aaaatcactc gaatttgttt tcggaagaaa cctaatttcc atagataatt ctttttcata
     5941 attaacataa taatcttttt gcatgtctgg attatattcg attttctcaa ctattacagt
     6001 attagaatag atagaattta tgaactctga atgctctatc ttgttgaaat ttaaacttat
     6061 tatctcatca ctaaagatta tattctcaag atttaaaata gctagtccat ctttttgtat
     6121 tgttttatct atgaggtaac tctttattac attgaaatta ctagtcttat atttacttac
     6181 caatagtgca atagcacccg atactttggg tgtcgccaac gaattaccaa ataaatatga
     6241 aaatcctgtt ttttgtgctg tcaatatcca gttttcagct atttttttac gtagcaaatc
     6301 aaggtcagtt acagagtaca aaaattctgt agaaccagca tatgtataga ttgcattata
     6361 gccataattg gaaaaatttg ataaattatc aaatctatca attcctccaa ctgatattac
     6421 attatcaaaa tatgctggta catcaacaat ttgaccgggt tcacgaatct tctttgttct
     6481 agataaaaac tctaataact gattattatc taagaggtta agtgagtcat ttcccattga
     6541 agctacaatt atactccctt tcaatgtcgc ataatcaact gcctgtttat actttaggta
     6601 tagtggataa tcattggtac catcttcata ttgaccactt atcattaaat atcttcctag
     6661 actgatattt attatttgat tcccgtcatc cgcagcctgt ttaatagcat caatagttaa
     6721 ttgatcatca ttgatatcta ggtcaataga cttgtacata ttataagtag cgcctggtat
     6781 tataccttta atataatcat tactaacaat caaagaaacc acagacgtac catgtccaat
     6841 attatcctga aaagcatgct cgtccacttt attatgcact aaatccttcg aattagaacc
     6901 tagatattta actaattctg catgctcata gcttattcct gagtctatta cagcaactct
     6961 aatatcatct aacggccaat aatgcttata atatcttcca ttatcagtaa gtcgttgcat
     7021 atcccactga tatttccata aattttgttc ttccgattct tgtccttcag agttgctttt
     7081 gttaaacaat cttagcgtta ctttgtcggt tttattaaac tcatcagtag tattcagttt
     7141 ctcaacctct gtacttgaaa tagctatatc aacttttgat gaaactgcat gcctgtcaga
     7201 acttctatct gtttgctcag caacaccatt cttatttccc gcctcccctt ctaaataatt
     7261 caaattatca tcaatagtag gtactgattc cgtagaaaaa tttttaattt ctgtaatctc
     7321 ttctaagaaa tttgaagtgc ctctatctaa actttggggt aactctacat tcatgctatg
     7381 attataagaa atttcatcaa atgaatcagg ttttatattc gctaaactat aagtagtccc
     7441 agcaacttct tcctgcatca agacattgct atcagcagta acagtctctg aggaagttat
     7501 acaaattaaa ccaattacta atatagatag ccttataaat ttatttgtga ttttcattta
     7561 aaaattcttt cttgataaat aacaaaaaca tagttatata gaaaactaaa attaaaactt
     7621 ttactaaaac ttgagaaatt aaaactaatt ttatatgtgg aaacactaaa aatgaaatta
     7681 atgttatatt taataatagt aatagtgcaa caataaattt agatacaata aaactagtaa
     7741 atttaatatt tatattatta gttgtaataa ctatatgtag attagattgc tgaattttat
     7801 caataacaac cttcagaaat gaaagagtaa aaattgttat caacaatatt attaaaatat
     7861 tattcactaa tatatttttt aaaatatttt ctatcatgag attcctccta cggtgataat
     7921 tctatcactc gatgctataa ttgctggatc atgtgtaata attataatta tattatcacg
     7981 ttttaattgt tttactgatt ctataaacca atcggtataa actttatcaa ggttggatgt
     8041 tggctcatca taaattttaa cgtttacatt agataaaaag ctttctataa tacgtaatac
     8101 ttgcagttcc ccgcctgata aagatgaatc aacttcactc cattttgtta ccaaaacttc
     8161 gttaattata tctgtatcaa tatttttatc atgtaacaaa tataaaatgt catcaacagt
     8221 ggcacaagaa gtattcatag taaaaaaatc ctgaacagtt aaatcaaata taggaaattt
     8281 ttgttcaact attgtaaaat tgtttcttct aagaaaaaca gtatttaaat ctgtaattga
     8341 atatccatca acattaataa tgttaccttt atcttttagt atgcctgtaa ttaatttata
     8401 aaatgtactt ttaccacttc cgttttctcc tataatagac cacaaaccat tgttggaaat
     8461 atcaaagctt aatggcggat atgacttgtc ataggccctt gtaatactgc ccgaaattga
     8521 atgaattttt ttatgtaatt caatatttcc ctctctgtca gttgataaca accagaaacc
     8581 ttcaatattt tgaatcgatg ctttaaaagc ctgtaaattt cctccaaaat caaaaaaata
     8641 ttcaatattt gacaagatta tagaaaagta agataaagaa acatttacaa taccaatttc
     8701 cagattatcc ctcataacat aaaaagcaac gattgaaaac ataacaacat taagcaacaa
     8761 cgatagtata gattgtaaaa atctaaattt agagttaatt ttagtaaatc tatctaacga
     8821 tgcaaaatat aaattaaagc tattgttaaa tcttttattt tctaaataat agttcgcttt
     8881 atgtattata taacttagat tatcaacctg ataatgaaat tgattataat aaatcgatgt
     8941 actatttttt agtgaattgc tggcatcaaa aatttttttt ctaaaataaa tatatatatt
     9001 tacataaaaa aatgttacca taacaaatac aagaaaaata agatactgtt ctcgtaaaag
     9061 atatatcaaa atcattgctg tttgaataat tcttagaaaa tatattataa aattatctaa
     9121 taaaaatgta gtaatttgcc ctaaatccag atttactctt tgggttagct cgctagcttt
     9181 tatcttagtt atctcattat aatttaactt cctaagaata tttaaaatat ctattcttac
     9241 agtttgactc actttttcag aaaaatgaat tgctaaaaac ttatttataa attgtaataa
     9301 ctgatttaat agtcctacta aaaacatata aaatattgtt gttttcaggt tgttcaagtc
     9361 atgactaact agctgattta gaaattgccc agttaataat ggaaataata attctaaaat
     9421 aaaacttata aatacgatta tgttgtaaat agaaaatacc agcctctgat tccctatata
     9481 tttatatact atcttcatat atcttaaatc cttgctgagg ataactatga aaataagatg
     9541 agatgcatcg caaaacttaa aaaattagca atatatctca tcttatccta ccattttatt
     9601 atattctata aactaataaa aattttagac ttgttcagaa acatactata tttataaagc
     9661 atataaagct attaatataa cttttttgca atgcttatac agtacactta gcagacaaca
     9721 atacctacat ttctatttat tttcaatata aagtcaacct ttacatctca cactttgagt
     9781 agaccagaag cctgtaacag tagtcactgt aaaggtaaca gtggtaggga agcgtggatc
     9841 gataccttgg gttgcaccag atactggtaa tttctgtaaa tcaagtacag atgttacttg
     9901 gggaatattt tttgacataa ctaaatcctt tctaaagtag aaaatacact aagaaattta
     9961 aacaactaaa agaaatttaa acagctaaaa aacattcttc ttagtacatt ttaaacaccc
    10021 cctttattaa tattggtaac cagagaaatg gattttgcct tttccaagct tcaatagcta
    10081 gtatagctcc tgagttacct gtcagaatat ccaatgataa ccggacagcc ccacgacctg
    10141 gcaaaacaag tgtctcccct ctgttaacca aatataaatt taaaagtaac ataatttctt
    10201 tcggaacatc tttttcttct aaaattgcta ataatagtat ttgtccaaat gctcccgata
    10261 aaaaattacc atcataaaat gtaataagtt ttaaattatt ctttattttt tttaattttt
    10321 catcgaatga attatcattc agaatatact tgagataata ccaaactaat gagaccccaa
    10381 cactgcccga ttctaaatag ggcatcaatc tattttcaga aactgtcagt tgaataacac
    10441 cagtaggcac atcctcaatt aacttcattt ccattttatt taaaattaat atagcaattt
    10501 cataataact ttgatttcca gtctcagaaa agagtaccaa taacattaaa gcaattcctg
    10561 aaactcctgt tagcaaatct aaattatcaa atttttttat ttcttcctct atataaaatt
    10621 tatgcttgat aaataaattt tcagttttta ttctgatact ttcatgaatc tctgaattat
    10681 aattgccaat acttaataac cctagaacaa tcccacttac tcccgatttt aaagataaat
    10741 ccgaagttac ttcaaacgaa tccaactctt ccaataagct gcgagataaa tcatccgcta
    10801 tttctatctc cccaattgag tacaaaacat taattattcc agttcttcca gtaagaagtc
    10861 ctaagtcaca tttttttatc aagtcctttt gagatattat ccaattttta taactatgta
    10921 catttgcccc acccatatgc aaagcgtata acattcccaa gccacctgtt aaatagttta
    10981 tttttccata actatctaaa tacgcatcca gctctccata tgaaaaaata tcttcttgaa
    11041 taacattatt cacaatacca ctaactaatc ttctctcgat atcttcaaga tcataattga
    11101 atagttctct atcgtgaata cctacataat cagaaaaata ctttctaatt atctccttac
    11161 catatatatg gtttatatag ctatcttgaa tattatgttg tctgttatcg aagttatcaa
    11221 taggtgctat cggcagaagt aagtatcgaa taattttctt aagagatttt ttatcatttt
    11281 cttttcttgt gcaatcatta ttagaaaaac catatgttgc tagtcctgag tatttttcgt
    11341 ttacatcgcc tgctgtttca aaatcaatca atcgacactc taaatcgtca ttaatcataa
    11401 tattactagg ttgtaggtct gacaaaccaa ttccatcttc atggatagta cttaaaatat
    11461 actcaagttc atttgcaatc cttctaactt ttaaaatata gtctgtttta tcagtttctg
    11521 aagtatattc aaaattaatg gtacaccatt gtgttaacgt aatccctgtg ataaattctt
    11581 caacaagata ataattttcc cagtattcaa aagcttctat tgagtttact acatattcat
    11641 tgtctttcag cctttcaaga acattatact cagattttaa cctttcgata atagattttt
    11701 tctgagaatc aaaaccagtt gaagaacgcc cctccttaat aacaactttt ctatcactac
    11761 ttcttttctt agcaacatat ataccaccgg aagtcgtata cttcaatgat ttcagaaata
    11821 tgtagtcatt aaatctatct tgattttcca gaacttctga atgtacgcta ttaatactct
    11881 cctctaaaca tttgggaata ttaacaaagt taggaatgtc aaaaaatggt tctctcttat
    11941 ctggataata gttcccctca ggatccagaa tacataattc accctgattt tctattcttt
    12001 ggaatgctcc atatctaaaa aaaatatttg agtccttata tcttctatcg gtcagaacat
    12061 aacatgcctt agtaaatttt tttaatatat tatataaatt ttcaagaact gtagcaagca
    12121 tatcttcctg aggatagata gtgataaact tgccagaaag taatctattt ccattcttcg
    12181 acaaagtgtc taaaagatct atctttgaat aaatgtgctt aaacgagatt ctattttcaa
    12241 acaaatatga tgcaacttct cttaaaactt cttcgctttc ctcatactta acactaatat
    12301 gtaatttcca gccctgaagt ggtagttcat ccgctttaga agtataatat acccaaaact
    12361 tattttctga aatgatacaa tcataatctt tagggatatt taacaattca aaaatctcag
    12421 tgacatttat attatttaac gaatcaacaa aaaaatcatc atctgctact aaataccttg
    12481 aattttccat atcattaaaa atgctcacaa caaactaaat atatacgatt ttgtgtagca
    12541 tcccttcttt tataattttt caattttatt acaacaccca tttaaacata tttaaaactc
    12601 ataaaaaaca agtccttatt ctctctttga aaacaaggga gaacctattg attttgctat
    12661 aataaaaata tctagtaaag tcatcaaata ataactttat tttaagctga ctaataataa
    12721 attaaatttt agtttgtaaa atagaattat tagcttttat tttgatttta agggagcagg
    12781 aataatctaa tctgcttttc ccacgtctaa accatttgtt tttttagtag gttgaatttg
    12841 tacatcaaac cttgtattat taaatagttg ctggtaatga acagtatcac ataataatgt
    12901 gtatcctaat aatagacaag ccaatgattt tattattgta ttctttttca taatctgaaa
    12961 accctttctt tttattgatt taattctatc atttcactat gcttccgtca atagttttta
    13021 tgaatatttt gcctcttttt ttattttatt actattaaga atataccgca tctagatatt
    13081 tgctatttta gactaaaagt aatataataa accgtgagat tatcataaaa ggaagtgaca
    13141 ttattatgaa tatggtagct gaaaaattca gattaaaacg aaaagaacta gggctctctc
    13201 agaaagtact ttcagagggt atctgtgaac aaagtcagat tagtaagatt gagcgaggaa
    13261 attttatgcc ttctgcagat cttttgttca aactttctca acgtttagac gttcctctag
    13321 attacttctt caacgaacaa attgaagtac cgtctaacct ttcaaacttt aaacaccttt
    13381 ctagtcgcct attagatgat agaaattatg acgatttaga atatctatac aaggtagaga
    13441 ctgataggaa tacatttcta tcttcagaag atcgtatgta tcttgagtgg gttaaactca
    13501 tcattgactt ctataaatat gatcttaaag ataaagctat ttcctcttta gaaagcatgt
    13561 tatcaaaaat ttctccaaaa actcaggtat acttgaaggt gctaaacaca ctatctaact
    13621 tctattcctt agttgggcgt gaacaagatt atgaatccaa ctattctttg ttaatgaaaa
    13681 tctatcaaac aaagaatctt gatcatcaag agtttctctt tggctatatc agagttcgct
    13741 acaactacgc tcattattta gtattcaaag aaaaatataa tgaagctata caagaggctc
    13801 ttgagactat tgaattttgt aaatcgaagc agacaagtta tcaactggct ccattactca
    13861 tactcgttgg gaactctggg gaacagttct tggataaaga gcaggtcaaa aactattatt
    13921 tagaagcaag agagttatgc aaaatatatg gtaacccatt aatgttaatg aagatagaaa
    13981 attatttgaa agagctggat aacaattagt ttatatttac ttttgaatac ctccttgcaa
    14041 tgtcacgttg cgctctaaga aagggagcct taaaaaagaa gcttggattg ggcttctttt
    14101 tctatcattt aaacgatgca ctagctgatt caatctttct cgaagtaaac gatgtccatc
    14161 ttctcattga tggtttcgat ttctcctgtt ttctgatagc ctagcttttc atacaggtag
    14221 caattccctg cttcttgaag gatagtgtct aatttccagt gattttgtcc gtgaattttc
    14281 tcgatttggt aaaaggcttt ttgagcaaag cccttacctc tgtagtcttt catgataaaa
    14341 attggcgcta cccttttcct acttccgtct ttcctatcta ccacgcgcac tgcaccaacg
    14401 atagcactat cagcacagat atagtagaag taagtttctt tttgctttaa cttagcctca
    14461 atcttttcta gagactcatt tccgggattg gtttcaaaat cgtgatactt gtccaagaga
    14521 tccttgaagg cttctttctg caataataac aacttctctg catctgaaat agctattctg
    14581 atcaaatgaa cttcttccat caacatttcc tcatccgata ttttttctag caaatttacc
    14641 gctattatac catgctcaaa catattttta aagggtcatt ttatcttgtc ggagcatttc
    14701 ctgagcgtgt tttttatggt agactaaaaa tagattagtt aaaatcttct tttgatgcta
    14761 taataactct aggtgttata gcaagaagct tttatagccc actaccccaa ttatttctga
    14821 aaacatattt gctgtttggc atttggattg gatactagca aggagggatt tatgttactc
    14881 agcttacaag gttctatggc tgttggtaaa agcacagcta ttgattatat acagcaacac
    14941 gcgcctgata tccgtattct tcctgaggac aatagggaca ttattcaaaa gctgcgtctc
    15001 cttgatttag acaagaccca gtttgaggat tatgtcacca ttcagcgcta ctggattgct
    15061 catgagatag aacgctatca gctggctaaa gactccctct atactctggt tgactggggc
    15121 gctgaggaaa tggcctacta tacccttcat tttccaaaat cgattggcaa ggattgggat
    15181 atcgcaactg ccttggctcc ggagttaacc gccttaaaag cttgctttcc tgagagaact
    15241 ctgtttttac aaactggaca ggaaaccttg caggagcgaa aagacagcga tagaacacgt
    15301 cgtcgaaact tcttcaacca ctacacccaa catctcctgc ctggcaaatt agcctggcta
    15361 caaactcagt tgcccgttga tgtgctagct gttgaccagc tcagctccga ccaagttggg
    15421 caggctgtcc tagcttggtg tcagaagcat tttggattga ataatcagtc tgatcaagtt
    15481 ttttagtcag gctgtttttc catctggcct tttccctcca tttgtggtag actaagagct
    15541 atgtgatagt acaagaaagg aagaaccatg acttatcctc atttactaga gcgttttttg
    15601 acctatgtta aagtcaatac gcgttctgac gagacatcaa cgacaacacc ttcaacccag
    15661 tctcaggttg attttgcgca caacgtctta ctacctgaga tgaagcgcgt tggccttcag
    15721 gatgtgcatt atttgccaaa tggttttgcc atcggaacac tgccagctaa cgatacaagc
    15781 ttaacccgta aaatcggttt tatcgctcac atggacacgg cagatttcaa cgcggaaaat
    15841 gtttcgcctc aggttattga aaactacgat ggctctacta ttgcccttgg aagctctggc
    15901 tatgaactca atcctaagga ctttcctcag ttgaccaact accacggcca gacattgatt
    15961 acgactgatg ggacgaccct tttaggtgcg gatgataaat ctggtatcgc cgaaatcatg
    16021 acggctattg aatttttggt ggaaaatcct gacatcaagc actgtgagat tcgtgtcggc
    16081 ttcggtccag atgaggagat tggtgtcggt gctgacaagt ttgatgtgga agactttaac
    16141 gtggactttg cctatactgt cgatggtggc cccttaggcg agctccagta cgacaccttt
    16201 agtgccgctg aagcacatct agaatttatc ggacgtaatg tccacccagg aactgccaag
    16261 ggtagcatga tcaatgctct acagttggct atcgactttc acaaccaatt gccagctgat
    16321 gatcgccctg agttgactga aggtcatgaa ggcttcttcc atttgatgaa aatggagggt
    16381 actgtggacc atgcaacctc tagctatatc attcgtgatt tcgaggatca ggatttccaa
    16441 aatcgcaaag ccttgatgca atccatcgca gatcagatga atgcgaatct agacactgaa
    16501 cgtgtggtct tgaacatgca cgatcagtat tacaacatga agaaaatcat cgaaaaagac
    16561 atgacaccga tcaatatcgc taaggcagtc atggaaacac aaggtatcga acccctaatt
    16621 gagcctgttc gcggtggcac cgatggttcc aagatttcat ttatgggcat tccgacacca
    16681 aacctctttg ccggtggaga aaatatgcac ggacgctttg aattcgtctc actccaaacc
    16741 atggaaaagg ctgttgacgt gatcatcggg attgtcagtt ataacgattg aggatgttac
    16801 cactcttcaa taccaaagaa gcctaaagac attgttctaa ggcttttttc tatcattact
    16861 ataaccaagc tggtatttct ctatgttttg tgttaccatc aacttatgaa aactcaaaaa
    16921 agttgcgaaa ttctcctatc acgctttgaa aatgccagaa atctcacaaa ggcacagtcc
    16981 atgtcagcct atatgcgcca ccagtttgac ttttatggca ttccaacacc agaacggcgc
    17041 aagatttata aggacatcat cagcaaggct aaagaatctg agatgattga ctgggatttg
    17101 ctcgacatca tgtggaatca acccaaacgc gagtgtcact actttgtctg tgactatctg
    17161 gtggctgtga ctgcccatct gactatagca gatctcccca agctcatgta ctttgctcaa
    17221 acccagcaat ggtgggatac tattgatcac ctagactatg tttttgggca tattgctgat
    17281 gaaaagatgc cagaaattct cctagctatg tccttatcag acgatttttg gcttcgtcgt
    17341 attgccattg accaccagct aggcaaaaaa gagcagacag atacagagtt gcttcaaaac
    17401 attattctca ataatctggg aagtcaggaa ttttttatca ataaggccat cggctggagt
    17461 ttgcgtgact actctaagac gaatcccgac tgggtgcgaa actttatcga ccagcaccat
    17521 gaaaaaatgg ctcccctatc aatcagagaa gccactaaat acttgtagca tagcgaaaac
    17581 ttggatgatt ttaactttga cttaaaccat ccaagttctt tttctgtcta attttccagc
    17641 aattcttcca ccttatggtc atcaaaggct tcttcgtgag gtaagatgag gttgagcaga
    17701 atacctgcaa tggccgagag cgctgtacca gacagagtca ctgcaccgat ttctagaata
    17761 gcgccaccga gaccaaggac aagcatggag ctagcaatga tgagattacg cacctgacgg
    17821 aagtcaacgc gcttttcaat catcaccttg agaccgttgc tggcgataac tccgtagaga
    17881 aggatggcca ttccacccaa gacagcattg ggaatggtcg agataagagc agtgaatttc
    17941 ccaaagaaac taagccccag agcaatcacg gctgcgtttc gaataaccga tactgatgca
    18001 atgcgcgtca ttccaatgac accagtattt tcaccataag tcgtgttggc aggaccaccc
    18061 atgaaagcag acactgctgt cgccacacca tcaccgatca aggtacgatg gaggccagga
    18121 gatttcaaga actgacgacc acaaatttca ctcaagaccg tgtgatcacc gatatgctca
    18181 gcaatagtca ccacagctac tggcaggata gcccaagtct caggtccaaa gtaaagatca
    18241 taggtgttga agagaccgcc tgtttcaaag ggcaggtaaa aaccaggcaa ctcgaaccaa
    18301 ttcgcttcga gaacaggagt aaagtctacc aagccaaaga aaatcgctac aatgtaacca
    18361 ccaattatcc caaataagaa gggaatgatt ttcaagaagc ccttggcttt ggtgttaata
    18421 aaagctgtaa ttaagaaagt cacgatagcc acgatgatat ttttcacatt gccatttgcc
    18481 acaaagccag cattggtcac agcagagcca gccaaaccaa ggccgataac cataatcatt
    18541 ggcccgatca caatcggtgg caagatgcga tcaatccatc tcgttcccaa gaccctaacc
    18601 atcgcagcca caatcacgta aatcagacca actaggataa cacctgtctg agccgccttg
    18661 atgtcaccac ccatttgctc aatagcaaag gccattgctg aaatataggc aaaagatgag
    18721 ccgaggtaga cggggactcg aaactgagtt gccaccatat aaataagcgt cccaagacct
    18781 gaagcaaaga gagccactga cactggcatg cccaagatga gcggcaccaa gatggttgca
    18841 ccaaacatgg caaagacgtg ctgtatactc agcaagagcc ctttagcaaa cggtggattt
    18901 tgatccacat ccaacaataa attcacgcgt gaagtgcttg actccatgat tcctcttttc
    18961 cgggcataca aaaagcccta ttttattgca atagggccta gtagttttcc ggattctacg
    19021 tgcctttgtc acctcacagg atgacattaa aagcccttcg ctgtatgata tattaccaca
    19081 aagatgatta aaaatctagt cttagcgtgt gaaaagtcgc caatctttta aagttcacca
    19141 atagcagagc gctaaataag gaaacaagtc ataccatgtg cgcaagtgaa tcagagctgc
    19201 tataatgaaa tttagttttc atcgcagtta ctcctagaaa aaatgttaaa cggaaataat
    19261 ctatgattaa gaaacaaact attttaatac cagttacaac gctcattctc tttatcttgg
    19321 gactccttta catcatcctc attgccaaat ctgagctact ctaacgattc ctcagcctga
    19381 gtgatcacac tatctgctac tgacaactca ctcgttgcac tgtctgatgg ttccgttaca
    19441 acttcttcca tggtatgcag gttgacaaga acaatagtgc catcaggttt ggtgatacgg
    19501 acttctgttt cattgatgaa ctcaagatta tcctcacttg cccaatatcg gaagcaaaga
    19561 gttcctatcc ttttctcaaa ctctttctgg tccatatgat actgtttggc cagcttttgc
    19621 atcttcaatg tatggtcatc gacctcgtcc tcagtatctt cttctggttc ctcgttgata
    19681 tcgtaattgt tgtcttcttt gttgccaggc ttatcgtggt cgctgtcatt gccccagcct
    19741 tctttcaatg ggcgctcaga tggattttca acgtaatact taatcgttgc catgagttcc
    19801 tcgattgtgt agccttctgg agcttcataa atagcacgtg ggccgtcaaa atagttgaga
    19861 tctagattat gataatgatc gtgatgcgga atgatcagca tcccatttcg ataagcaact
    19921 gcctgatcgg ctcggtaagg gatcttgtct actggcacaa tcttagctgc tttaactgtt
    19981 tcataaattt caggtgttga tttttttcta gagccatcag aaggattctc tggcgtttca
    20041 ggaactgctg gtacctctga ttgctcaccc tttttagctt tccagaaagc ttctgctgcc
    20101 gccaattcct cagcagacaa atttttctta ggaatccaat gcgtatggcc catatgaggc
    20161 gtcagataag cgtctcccat atcgtcaatg atgtccttag catcaaagat ataaccgtct
    20221 gaggttgtgt attttcctgc tgctttagct ttggcaatct cttcaggact gtaaacgatt
    20281 tgcgaatttg gtttcccttt tcgctcatta agcggtgtca caccatgatc atcttttggt
    20341 ttatctggtg aaggtggtgt tggtacattc ggcttggctg gcttaacgat gggcttttct
    20401 ggtttagatg gtttaacaat tggttgaatc ggctgcttag gttttggctg ggttggttgg
    20461 gttggagcga taatagactt gtcatcaatc gggtggcctg ctgctaacag tttcgtaatc
    20521 tttaactcca aagcagacat agaactataa ggtatgaaat gataatggtt accatgtgga
    20581 accgcaacac ctgtgctgct gaagcgcgta atagtcctag gatcatagac gagtccatct
    20641 acttcaacat gacgttcact taatggggta cgatccaact gtgccaaaag acccgctagc
    20701 gtttcaccag gttgaactgc ttgattaact gaattcgttc ctgactgtat cagatttggt
    20761 gtgccatctg gatttgcagg ttggtagtga attgactgat tcatttgacc ttgagcattg
    20821 gcatacggtg gacgaacagg gtttcctttt ccgacttttt tatcccaata ctcttgagct
    20881 gcagcgagtt cacttgctga aaggtcagct ttaggaatat agtgaaaatg atctccatgc
    20941 ggcacaatga atgcatctcc taaatcgtct atgacatccg tcggactaaa gacataacca
    21001 tcatcggtcg tatagcgacc tgatgttgaa acagaagaaa gtgttcctcc attttcacga
    21061 tgccctgact ttttactagc cctagcttgt tgctctgcca cctctgcctt gcttctaatg
    21121 ttttcagact tgctgccttc tttgaggtaa agatagtatt tcccttcgac tttgataata
    21181 tagccatctt taacttcatt aatcacatcg gattgcttaa aaacatagtt aggatccttc
    21241 atgatcagct cttcactcaa aatcgcatca taaggcacct taccagtata gtagtggaaa
    21301 tgatccccat gcgcagtgac gtagccatca tccgtaatct taatgacaat ttgctcagca
    21361 gaaatgcctt ctttagcact gacctcatca ggtgtcatac ctttagtatt cgtaacaacc
    21421 ttactgtcct ttccactcgc atccacatag ctgacttggt tagatccagc ctcatcttga
    21481 ccttgctgat ggccaaggta ataagcacca gcacttgatg ccaaacacag gcttaggact
    21541 gcgctactga ttaataattt ctttttattc atttatgctc ctttgttgtt tattggttta
    21601 acgttttaac gagaatctca aggtttttct ccagattctc taaataagtt ttaccgtttt
    21661 gagggtcaat ttcgagtgga ctgagctctg ctatctttgc ccctgtagcg gaggcgattg
    21721 tttcagcgat tttaggggaa acgccttgct caacaaagat cgtcttgacc tgataggctt
    21781 tgacaaactc ttcaatctca gctaattgac gggacgttgg ctcctgctca gtcgagatcc
    21841 cagcaatccc taactgttcc agaccaaatt gcttagccaa atatgaaaag gccgtgtgcg
    21901 aagtgacaaa gtgctttgat ttggcttttt taaattgagg ttgatatttt gccacaagct
    21961 gtttcgcttc atcctgaaat tgctgagcat ttttttgata aaccgaagca ttatctggat
    22021 ctatctttgc caactgaccc gctatcacct tagcttcttc tgctgctttg agtggatcat
    22081 tccacgtatg aggatcataa agcgttgact cgtccatgcc ttctctggct tctatatctt
    22141 ccaatccctt gaccttatcc aaaaccatgc cttctgtcgc ctccaagaca cgaacgctag
    22201 aaccttgcaa gtttggatcc agtgcccctg cccaactctc taaggtatga gaatggtaga
    22261 taaaaacgtc cgcatcataa atagcggcaa tatcattggc agatggctcg aagccatgaa
    22321 tcccctgacc ggactgaatc attttgacac tgttcaaatc tcctgaaaca atctttgtta
    22381 gcgcataaat aggataaaaa ctcgtcacaa tcttcaatcc aacttcttct tttttaggtt
    22441 ttgtttgccc acatgccgca agtaataaac cagttaagca tatgattaaa
//
