LOCUS       NZ_LT906439            24218 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Streptococcus merionis strain NCTC13788 chromosome 1, complete
            sequence.
ACCESSION   NZ_LT906439
VERSION     NZ_LT906439.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus merionis
  ORGANISM  Streptococcus merionis
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JUN-2017) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900187085.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 13:40:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,228
            CDSs (total)                      :: 2,160
            Genes (coding)                    :: 2,111
            CDSs (with protein)               :: 2,111
            Genes (RNA)                       :: 68
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 27 of 49
            Pseudo Genes (incomplete)         :: 28 of 49
            Pseudo Genes (internal stop)      :: 10 of 49
            Pseudo Genes (multiple problems)  :: 16 of 49
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:09:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 478516
            Orig. end                         :: 502734
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT906439.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24218
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24218
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24218
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14218](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14218
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            723..2507
                     /locus_tag="CKV83_RS02180"
                     /old_locus_tag="SAMEA4412692_00441"
     CDS             723..2507
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373775.1"
                     /locus_tag="CKV83_RS02180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00441"
                     /product="glycoside hydrolase family 3 protein"
                     /protein_id="WP_018373775.1"
                     /transl_table=11
                     /translation="MTHLVDLKKMPYNLDDEAINWVEETLASMSLEEKIGQLFVNMGAS
                     RTEEYLTEMVDKYHIGAVRYNPGTSEEVYDQNWILQTKSKVPLLIAANTEAGGNGACTD
                     GTEVGKEVKIGATDNRRYAYEMGRVSGVEAAAIGCNWSFAPIVDLNRNWRNPIISSRSW
                     SDDADRVLEMSLAYMEGIQESGILPAAKHFPGDGVDERDQHLSFSVNSYSTKEWDASFG
                     KVYKGLIDAGLPSIMAGHIHLPSYEKELDPTVTDNDILPATLSKPLLDGLLRGKLGFNG
                     LVVTDASHMLGMTSIMSRREAVPTAIEAGCDLFLFYNDPDEDIAYMLEGYQKGILSDDR
                     LHDALRRALGLKAKLGLHKKAKTAILPPKEEALAKIGLPENKAIFREVADQAITLVKDK
                     QKDLFPVTPERYKRVLLVPIKGIEGGFGAMINHGKPKSVDLLKEILEEKGFEVSIWEAV
                     EDKIKKLPPEEQFAAIRNVYAQKQSIASLTENYDLIINLADVNTGATVQRIVWPASKGT
                     PDIPFYVHEVPTIFVSVQSPYHLADVPQVGTYINAYDGNRETLEELTKKLMGESSFKGI
                     DPVDAYCGLIDTHIWRSH"
     gene            2521..4245
                     /locus_tag="CKV83_RS02185"
                     /old_locus_tag="SAMEA4412692_00442"
     CDS             2521..4245
                     /EC_number="3.2.1.-"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001137776.1"
                     /locus_tag="CKV83_RS02185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00442"
                     /product="glycoside hydrolase family 3 protein"
                     /protein_id="WP_018373774.1"
                     /transl_table=11
                     /translation="MSKIVDLTQKPYNLSPSQIAWVEDTLADLSDEEKIGQLFVNLFFF
                     GGDMFSGNNLSNQEILKKYHIGGARYMNGTPEQVQGLINELQEHSKVPLLVAANCDSGG
                     DGAVKGGTYISSGAQSEASRDTRVPYLAGLVSAREETALGVNVNFDPCVDILENWRNTI
                     VNTRAYGTTAKDVITYTNAYLDGLTAEREVIQCIKHFPGDGTEERDQHLVLGVNELSPT
                     EWEDSFGEVYRNHIKRGVEMIMAGHIALPHYQKQLNPDLKDEDILPATLAPELINGLLK
                     TDLEFNGLVITDASHMLGMTAAMRREDYVPQAIAAGCDMFLFFNDMEEDFNFMLNGYRK
                     GIITEERLNDAVRRILGLKAKLNLHVKKAEGTLLKSAEELSIIGCEEHLAWQREAADKA
                     ITLLKDTQKNLPISPETHKRIRLYYLEGEKGGIMEASNEVVDNLKAALERRGYEVTIND
                     GNTRIKGSTLKYREEVDLALTVANVVGYGAQNNYRIQWKMAMSNEVPWYVHEVPTIFVS
                     LNYTTHLHDATMVKTAINAYHHNPNTIESLIDKLEGKSDFVGVPNDLVWADKWQAKL"
     gene            complement(4382..5494)
                     /gene="ald"
                     /locus_tag="CKV83_RS02190"
                     /old_locus_tag="SAMEA4412692_00443"
     CDS             complement(4382..5494)
                     /EC_number="1.4.1.1"
                     /GO_function="GO:0000286 - alanine dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042853 - L-alanine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ald"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004253293.1"
                     /locus_tag="CKV83_RS02190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00443"
                     /product="alanine dehydrogenase"
                     /protein_id="WP_018373773.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3.2e-09, bitscore:
                     33.4, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIGIPKEIKNNENRVALTPAGVYALVQAGHQVLIETQAGLGSGF
                     ADADYVAQGAQIAPSAAETWAAELVVKVKEPLKSEYPYLREDLILFTYLHMAAAPDLAE
                     AMLLSKVNSVAYETVTNAQGQLPLLTPMSEVAGRMAVQIGSHFLTRQEGGSGVLLSGVP
                     GVPKGKVAIIGGGVVGTHAARIALGLGAQVTILDISAKRLSELEEVFGSQIQTLMSNPL
                     NIAEVVKESDLVIGAVLIPGAKAPKLVTEDMVKTMRPGSVIVDVAVDQGGVIETADQTT
                     THDEPVYVKHGVLHYAVANIPGAVPRTSTIALTNVTLPYILDLANLGFIDALNGNDGLR
                     AGATTFQGKLVSQPVARDLGLNYVPIEELI"
     gene            5794..6480
                     /locus_tag="CKV83_RS02195"
                     /old_locus_tag="SAMEA4412692_00444"
     CDS             5794..6480
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373772.1"
                     /locus_tag="CKV83_RS02195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00444"
                     /product="response regulator transcription factor"
                     /protein_id="WP_018373772.1"
                     /transl_table=11
                     /translation="MYKILAIDDDKEILKLMKTALEIENYHVTIYQEIQLPINVDDFKG
                     YDLILLDIMMPTISGIEFCQKIREKVYSPIIFVSALDTDKEIIQALNIGGDDFIVKPFS
                     LKQFTAKVNSHLKREERTKSKSEKNAREKRSFPPIEIYLEERMLYIEKEPLPLTYREYD
                     ILELLSRHPYKVFSKEEIYEQVYNEESSALFHSISEYIYQIRIKFSSFGINPIKTIRGV
                     GYKWDV"
     gene            6473..7828
                     /locus_tag="CKV83_RS02200"
                     /old_locus_tag="SAMEA4412692_00445"
     CDS             6473..7828
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373771.1"
                     /locus_tag="CKV83_RS02200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00445"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_018373771.1"
                     /transl_table=11
                     /translation="MFKKYSIRNRVWRTVFEIALGTFVTILMVVIMSLSFLKLNIVTSH
                     NVGERYRTEDKKTVKQLTNYMKSLGLDYVIFDKETNKIMEGKYLSKEISLFKKVVEEKS
                     NLTLNSVHYDLYTNNNYYVVIRYNEIPEFSNHYFRNISYNMLTFYFLGFGMSISIIVAL
                     TRFVKEISLNFKKIKRAANKMGRDSISEQESYSKIIEFDDILRTLHAKGDNLKNLIDRE
                     KLEKQDLSFQIAALSHDIKTPLTVLKGNLELLELTVLSTSQQDYTLSMNNSISVLEGYF
                     NSLISYTRMLSEERPAKLIIIEKLLNELHFEVNDLLNMNKVTYSLCNRLTSTSFYGDGS
                     HLMRALSNLLVNAIRFTPVSNKKIEVTLSESSNQIYFEIWNNGQPFSENTLKNGNKLFY
                     TEDYSRGSQHYGIGLAFVNGVATKHGGSLRLFNPARGGASAILSIKKNLQKL"
     gene            7978..8118
                     /locus_tag="CKV83_RS02205"
                     /old_locus_tag="SAMEA4412692_00446"
     CDS             7978..8118
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984803.1"
                     /locus_tag="CKV83_RS02205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00446"
                     /product="lantibiotic streptin"
                     /protein_id="WP_083903311.1"
                     /sec_met_domain="TIGR03731 (E-value: 8e-08, bitscore: 29.2,
                     seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNTIKDFDLDLKTTKNNSAEPLVGSRYLCTPGSCWKLVCFTTTI
                     K"
     gene            8227..10017
                     /locus_tag="CKV83_RS02210"
                     /old_locus_tag="SAMEA4412692_00447"
     CDS             8227..10017
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418808.1"
                     /locus_tag="CKV83_RS02210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00447"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_018373770.1"
                     /transl_table=11
                     /translation="MIKAQLKNLMKTINLVKEAGFSLLMFSIGISLFQGILPIFSMLLV
                     QNMLNIIASNIDRFHTLMISFTLYVILTLLTIIVGEVDGYIDTKLQILLHYKMNHLVMQ
                     KTVKLTLAEFETPEIYDDITRIQNQISYKPFQIYKSIISVLSSLVLFISSFIILLNWKI
                     SIFPLLIVLPIISIYIYLRIGKNEFEMLYRRSSDERANWYISHILTHDFAVKELRLGIL
                     ENYFLKKFDKNNQLFISQENSINKSKMKYGILLGILEITVESIIMFLAVREAFLGILLI
                     GNVTTFIRSLSTMQTSTQNIVNNIYSLYNGSLYMELLYDFTHDEIGYNNLTENIVEDIQ
                     SIEFEHVSFSYNGKENVINDISFSITSGEKLAIVGENGSGKSTIFKLVCGLYDNYEGNI
                     YINGINLRSIQKKSYYKRISALFQDFLKYELTLRENVGLGELSKLYSDEDLISTLKRTG
                     IDSIFYAKQEKTNQLDLEQQLGNWFEDGRQLSGGQWQKIALSRVYLKEADCYFLDEPSS
                     ALDPESETKIFKTFFELSQNKIGIFITHKPSITQFVDEILYLEDGGVVEIGNFNDLNTK
                     GMKFKNLLDKEIGIVYDTSN"
     gene            10001..11242
                     /locus_tag="CKV83_RS02215"
                     /old_locus_tag="SAMEA4412692_00448"
     CDS             10001..11242
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989896.1"
                     /locus_tag="CKV83_RS02215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00448"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_018373769.1"
                     /sec_met_domain="LANC_like (E-value: 7.8e-70, bitscore:
                     232.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPQIEQILGYVAGSFTNYERVVAESANKALINIEPKYQNTFFEK
                     SLSHGIPSLILMYSSLYKVTKQEKYIALSNIHIEKLVEIISKDGIESPSLYAGTAGISL
                     AIREASISGKYYTKLLSSLHCLLKEQTQEKLIISLSNIDKRIIEPFDYDMVNGFSGIVN
                     YLILEREYFFEELKQIGTYLLKYVETILYKVTNCSVDTKNELDLGIAHGIVGPMLTLAK
                     LKSERILKEDVEILNKAIKLVFLCRREDKLWPGKIYSDNILNFDFKNLPTRMAWCYGTP
                     GTALALFKICQLMDLNYTDNIVESLVAQMNSTEKNIYSPSMCHGLSGVAFIYDLIGRSY
                     SNVELANFADYLRQEIIMQFSEQKIFGYTDREKLGEVEVELESVGILQGVSGIVLFLLN
                     PYSDEELLWERMFI"
     gene            11261..14218
                     /locus_tag="CKV83_RS02220"
                     /old_locus_tag="SAMEA4412692_00449"
     CDS             11261..14218
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373768.1"
                     /locus_tag="CKV83_RS02220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00449"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_018373768.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3e-90, bitscore:
                     300.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.6e-11,
                     bitscore: 41.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8e-17, bitscore:
                     58.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYNIFPRGMIRIPLQKQEFYNKGYEELINDKVFMEQLLVASPSLY
                     NSVINIDKCNEKKKQNVKVSLKSYAKRAAFRTTPFGIFTAINVVDLTNENNSNVQKISF
                     AKKAAPDYLWVYSLVKSYEIKNIEKLDFKINTAAFIQGDRYVLPFTVNEFEEDRNISLL
                     KPVQILIEKCQKDYVSYEALINILKNSYPEVALEVLTSFIYNLVENDFLISDLRPPICN
                     INSLDYLLSKLEKGKLINDLHNLKNMIEDYNDLKIGEGSNLLLRIFDVMKNIHKYDNGG
                     NYLKVDSLAKFDGDFDILSEKSSETIKQFAGMFVKLNASVKRRGGRKNSFEEYQLKFIG
                     KYGENCAIPFVEVINKDIGIGFPEYYKDESGEEIELSDPIMQMFEKKYEDALLNGSGIE
                     FSSRDLDDFEIDQNNSLESFELNFNIKKLNNDVKLYLGANIGSGQAGRSFGRFYTLSER
                     LRTTIKKLNQQNCMNVELSFVPKQIRIANVMQNYSDESFNTSFFTTSWDSTNEIRLEDI
                     YIRYSEGKFHFTTRDGENELKFTMNNMLNSDSQSKVLRLLVDISEFEYGLSHWSLFPWD
                     ILAQERVYIPEISFEGITIATAQWNLSVMREQLLTQNKFTDKKVIFDNFRKTYKVPKDS
                     ILKYADNELRLDLSMDDDLEILFKNIKKYALVSLREIEKGESIFKEYLGNYNAEIVVPI
                     IKNLNKKVSRETKVIFKNEIKKTYLPFCDWLFLKLYGPKERQNELLSYWNHFFANRVPE
                     NCNQTKMFYMRYNDINDHVRIRVNCNSIENNFSLYLSVVHDLLPQLIENGIISDIEVSS
                     YKPEVNRYGGPDLISYAEEIFCKESILLMNNTIEFSDNERLICATYLVLHYLNYFFKDK
                     ETRLSFLFENYTGKYKKEFKNLPIDLPIEYMKSLNGVASALDKYDFFQEMDKYLASYME
                     EYNQFGSSNTIYNTKFNLVGSFLHLSMNRLNGIDREFEEKVYCFAYYTLNAQQYI"
     aSDomain        11663..11917
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CKV83_RS02220_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.40E-13"
                     /identifier="RREFam001.1"
                     /label="CKV83_RS02220"
                     /locus_tag="CKV83_RS02220"
                     /protein_end="219"
                     /protein_start="134"
                     /score="41.1"
                     /tool="antismash"
                     /translation="NTAAFIQGDRYVLPFTVNEFEEDRNISLLKPVQILIEKCQKDYVS
                     YEALINILKNSYPEVALEVLTSFIYNLVENDFLISDLRPP"
     gene            14233..14925
                     /locus_tag="CKV83_RS02225"
                     /old_locus_tag="SAMEA4412692_00450"
     CDS             14233..14925
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373767.1"
                     /locus_tag="CKV83_RS02225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00450"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_018373767.1"
                     /transl_table=11
                     /translation="MLKVQNLKKSYGKRTVLDNVNMNIPKGKVYALIGPNGAGKSTIMK
                     ILTGLINKTSGSIMFEGREWSRRDLRKIGSIIEEPPLYKNLSAYDNMKVVTTMLGISDS
                     TILPLLKKVGLGNIDKRPVKQFSLGMKQRLGIAISLINSPNLLILDEPTNGLDPIGIQE
                     LREIIESFKSEGMTIMISSHILSEVEHLADFIGFIYEGKIILEKEYDGSENLEQLFNGL
                     ILSERRLG"
     gene            14928..15677
                     /locus_tag="CKV83_RS02230"
                     /old_locus_tag="SAMEA4412692_00451"
     CDS             14928..15677
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984791.1"
                     /locus_tag="CKV83_RS02230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00451"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_026216959.1"
                     /transl_table=11
                     /translation="MTKIILSNLLKIKNTSIYKLVFLFPIICIMLSLLFSALGGESILR
                     LTAETTLNQWGIIWINVIISVNSGLLNKLEKDSNKYSIFLSRDVDLKKVEYTRVILIAF
                     INLTISIILGLMLVVVSLVIPTPSITSLGRILLTILLLWLTTLWQIPLTLWLSRKTNLY
                     FVMIINTISPLIIGTSFSLLDKWYLFPYDWSMKLLEPMTGMRINGIPFGSDFIPDYSLV
                     FISLSLGIFFFILLTELAAISFKRQVR"
     misc_feature    complement(14949..14963)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 24.34"
                     /tool="antismash"
     gene            15680..16402
                     /locus_tag="CKV83_RS02235"
                     /old_locus_tag="SAMEA4412692_00452"
     CDS             15680..16402
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373765.1"
                     /locus_tag="CKV83_RS02235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00452"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_018373765.1"
                     /transl_table=11
                     /translation="MKSYLQSNFIKIKNTSYLLVHILATLLFPLLLFFYWIQRGDIQNN
                     IALFSYFQIVGVLLPFASSIVTIQLKSLEEEAGKFKYLLGYSLSSYMPFFIELIFLWMC
                     YCIVLLVSFALFGIFVIMSGAIVNFQVVFLNISFYIILAFATYIINHIISYLCSIGVAL
                     GISMIGVIVAAFCETSLGDKVWFFIPWSWPLRISDVLFNQQKIASIHLIVMAIISIAML
                     LLHRRVFQNWNQDRLTES"
     tRNA            16771..16843
                     /anticodon=(pos:495320..495322,aa:Thr,seq:ggt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CKV83_RS02240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SAMEA4412692_00453"
                     /product="tRNA-Thr"
     gene            16771..16843
                     /locus_tag="CKV83_RS02240"
                     /old_locus_tag="SAMEA4412692_00453"
     gene            16912..17331
                     /locus_tag="CKV83_RS02245"
                     /old_locus_tag="SAMEA4412692_00454"
     CDS             16912..17331
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373764.1"
                     /locus_tag="CKV83_RS02245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00454"
                     /product="low molecular weight
                     protein-tyrosine-phosphatase"
                     /protein_id="WP_018373764.1"
                     /transl_table=11
                     /translation="MKKVCFVCLGNICRSPMAEFVMKSLTDELEIESRATSGWEHGHPI
                     HEGTQGILKQYGIAYDVKKDSTKMSSDDFEYFDVIIGMDASNVENLKAMSDPKYHNKIV
                     QFAEESVPDPWYTGDFEDTYQRVLSGCQEWVKKLT"
     gene            17402..17815
                     /locus_tag="CKV83_RS02250"
                     /old_locus_tag="SAMEA4412692_00455"
     CDS             17402..17815
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373763.1"
                     /locus_tag="CKV83_RS02250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00455"
                     /product="hypothetical protein"
                     /protein_id="WP_018373763.1"
                     /transl_table=11
                     /translation="MELIQYYYERLKPHLHRRNLEMAAAGLVVLCGLFVVLSGFPKTVK
                     TSYKDGAIVYEGQVVRQKMNGQGKLTFSNGDVYKGNFSNGTFQGKGKFTAKSGWVYEGD
                     FVNGVAHGQGKLTTENGVVYEGKFEKGAYQDAN"
     gene            17805..19634
                     /locus_tag="CKV83_RS02255"
                     /old_locus_tag="SAMEA4412692_00456"
     CDS             17805..19634
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373762.1"
                     /locus_tag="CKV83_RS02255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00456"
                     /product="acyltransferase family protein"
                     /protein_id="WP_018373762.1"
                     /transl_table=11
                     /translation="MRIKWFSLVRILGMSMVLLYHFLPSVFGGGFFGVDIFLVFSGFLT
                     TAIFLDEFGKTDAIDLVGFYRRRLYRILPPVLLMIGVVLPLTLLIRSDFRAGIGSQIAA
                     AIGFITNYFEIAQGGSYENQFVPHLFVHTWTLGIEVQLYLLWGALTWGLSRVAKSKEQF
                     RAYLFGLSSLFFLVMFGRFIWSSFNADNLSAIYYATGKHGFTFFIGAILATLSGIGQTT
                     AAFKQLSQKLDTKKVFGGILLALLVLGILTLVLTFENLWTYWIGFILASLAAVALILAF
                     RVLHEKTPNIAEPGVLIFLANISYGVYLFHWPFFIIFSEMTNKGVAIGLTLLLSVAFAS
                     LSFYILEPLVMGRAVKFAGVELDLTSAKKPLAIVAGVFALFALGLSLFSPRIGALEKDL
                     MIQGLEQADTKMAQTRQIVDGRIASDYGVYEGTLVIGDSVALRASDGLTDAIDGVVVEG
                     EVSRTLEGAYAFLQESIKNRTLPRDVVIAAGTNTIANYEEVLDNIIKAVPQGHRLILVT
                     PYDGRVAGNPASLANLTRDYELKLAEKYDWVTVADWYKVAINSPQIWHFTDYVHFGNDS
                     DSIREGQEIYAKTVTDALAKASKSSVRLTTKSE"
     gene            complement(19916..20629)
                     /gene="rsmG"
                     /locus_tag="CKV83_RS02260"
                     /old_locus_tag="SAMEA4412692_00457"
     CDS             complement(19916..20629)
                     /EC_number="2.1.1.170"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0031167 - rRNA methylation [Evidence IEA]"
                     /GO_process="GO:0046118 - 7-methylguanosine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="rsmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004187966.1"
                     /locus_tag="CKV83_RS02260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00457"
                     /product="16S rRNA (guanine(527)-N(7))-methyltransferase
                     RsmG"
                     /protein_id="WP_018373761.1"
                     /transl_table=11
                     /translation="MTPELFYKLLAEQGFELTSQQKVQFERYFELLVEWNAKINLTAIT
                     DKEEVYLKHFYDSLAPVLQGLIFNEPIHLLDIGAGAGFPSLPMKILCPELDVTIIDSLN
                     KRITFLNYLADELGLAKVHFLHGRAEDFAQQPTFRAQFDLVTARAVARMQVLSELTIPF
                     LKIKGQLIALKASSAEEENLAAKNALNTLFCHIVLSKDYRLPNGDPRNITLVEKKKETP
                     KKYPRKAGIPNKNPL"
     gene            20792..21361
                     /locus_tag="CKV83_RS02265"
                     /old_locus_tag="SAMEA4412692_00458"
     CDS             20792..21361
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002925599.1"
                     /locus_tag="CKV83_RS02265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00458"
                     /product="LemA family protein"
                     /protein_id="WP_018373760.1"
                     /transl_table=11
                     /translation="MAFIVSLIILVVLVAWGIGMYNGLVRSRMHTEEAWSQIDVQLKRR
                     NDLIPNLIETVKGYGRYEQETLEKVIKLRNQVASASNPTEKMAASDELTRQVSGLMAVA
                     EAYPDLKASANYTKLQEELTNTENKIAYSRQLFNSTTGNYNAKLQTFPSNLFAKFFGFQ
                     PSIFLAIPEEEKVVPKVDFGPNGLGD"
     gene            21363..22262
                     /gene="htpX"
                     /locus_tag="CKV83_RS02270"
                     /old_locus_tag="SAMEA4412692_00459"
     CDS             21363..22262
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="htpX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000895736.1"
                     /locus_tag="CKV83_RS02270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00459"
                     /product="zinc metalloprotease HtpX"
                     /protein_id="WP_018373759.1"
                     /transl_table=11
                     /translation="MLFDQISANKRRTIVLLLAFFSLLALVGYGVGYLWLQSGPTGTIL
                     ALVVGLVYALAMIFQSTNVVMSMNNAREVTADQAPELYHIVEDMALVAKVPVPRVFIIE
                     DDALNAFATGSKPENAAVAATTGLLRVMNREELEAVMGHEISHIRNYDIRISTIAVALS
                     SAITMLASMSQRMMWYGGGRSRRRDDRDGGDGVQVMILVLSLLAVVLAPLAATLVQLAI
                     SRQREYLADASSVELTRNPEGMIRALQKLEQSKPMSQPVDDASAALYINDPMKKGSLQK
                     LFYTHPPIADRIARLRQM"
     gene            22271..22804
                     /locus_tag="CKV83_RS02275"
                     /old_locus_tag="SAMEA4412692_00460"
     CDS             22271..22804
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002907072.1"
                     /locus_tag="CKV83_RS02275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00460"
                     /product="DUF177 domain-containing protein"
                     /protein_id="WP_018373758.1"
                     /transl_table=11
                     /translation="MFHLLDIKKNPEGLSFSEKLDLKANLQSRNPEILNIEEVTANGQV
                     KYENKMYFLDYSLSYKLTLPSSRSMEPVLLEQSYPVTEIFMEEADLRNLAGDIDEELVL
                     VIEGEQIDLSESVADNILLSIPLKVLTPEEEASAAFPEGEDWQVLSEEDYAASQAEQKK
                     ANSPFAGLAGLFEE"
     misc_feature    complement(23863..23877)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 cttagtaaat tgggcagagt caactacttc cctgtctaat gcttcgcttg agcaggcctt
       61 gcgtgacaat ccttcagagg atttagaaaa agctctagcg tggtcaaatg atgtcaatca
      121 tcatatcaag cattaccaag gagatgctct ggcctttcca aatgtgcgcg aggggcttga
      181 aaaactcagc cagctaggat cggtttatgt ggtcagctca gccaatcgcg aagcagtagc
      241 agaagaatgg gaagaccagg gtctcgtgcc ttttgtgacc gacctttact gtcaagaccg
      301 tggcaaaaaa gaggatgtct tggctgaatt gctcagtctg gtggacagtc cagatcagtt
      361 gctcatgatt ggtgattcgc caggagattg tcaggctgct gagctcaatc aggtccagtt
      421 ttatccgatt atcgttggag atgaggggca ctcatggcag caattaatgg cagttgaggc
      481 agatgctttt gtcgctggta actataacca agaccagtac aagcagctct tctggcaaaa
      541 tttagatcgt tgagagtggg atagacagcc atgacgacgc aagtgtagtt ataggttaag
      601 cttggtgata agagtctagg ggaatttgat ttctattctc attctttcaa aaacatcatc
      661 aagctgagtc aaggacagca gactttgact gttaacacct atatcttaat aaaggagaag
      721 acatgacaca tttagttgat ttgaaaaaaa tgccttataa tctagatgat gaggcaatta
      781 actgggtaga agaaacccta gcctcaatga gtctggaaga aaaaattggc cagctttttg
      841 tcaatatggg ggctagccga actgaggaat acctgaccga gatggttgac aagtaccata
      901 ttggagctgt tcgctataat cctggcacat cagaagaggt ctacgaccaa aactggattt
      961 tacaaaccaa aagcaaggtt cctttactga ttgcagccaa tacagaagct ggaggaaacg
     1021 gtgcttgtac agacggtact gaagtcggta aggaagtcaa gattggtgca actgataatc
     1081 gccgttacgc ctacgagatg gggcgtgtgt ctggcgttga agccgcagcc attggctgta
     1141 actggtcctt tgcaccgatt gtggacctca atcgtaactg gcgcaatcct attatttcca
     1201 gccgttcgtg gtctgatgat gcagatcgtg tgctggagat gagtctggcc tacatggagg
     1261 ggattcagga gtctggtatt cttcctgcgg ccaagcattt cccaggtgat ggcgtggacg
     1321 agcgcgatca gcatttgtca ttttcggtaa actcttattc cacaaaagag tgggacgcgt
     1381 cttttggtaa ggtttataag ggattgattg atgctggttt gccgtctatc atggcaggac
     1441 acattcatct gccatcttac gaaaaagagc ttgatccaac ggtgacagat aatgacatcc
     1501 tgcctgcgac tttgtcaaaa ccgcttttag acgggttatt acgtggcaag ctcggcttta
     1561 acgggcttgt ggtgacagat gcgtctcata tgttgggaat gacttctatc atgtcacgcc
     1621 gtgaagctgt tccgacagcg attgaagcgg gttgtgatct attcctcttc tataacgatc
     1681 cagacgagga cattgcctac atgcttgaag gttatcaaaa ggggattctc tcagacgatc
     1741 gcttgcatga tgcccttcgc cgtgctttag gattgaaggc taagttaggc ctgcataaga
     1801 aagctaaaac ggctattttg ccacctaagg aagaagcctt agctaagatt ggtttgccag
     1861 aaaataaggc cattttccgt gaggtagcag atcaggcgat tactttagtc aaagacaagc
     1921 aaaaagacct attccctgta acacctgagc gttataagag agttctctta gttcctatca
     1981 aggggatcga aggtggtttt ggagctatga tcaatcatgg caagccgaaa tctgtggatt
     2041 tgttgaaaga aattcttgaa gaaaaaggtt ttgaagtgag catctgggaa gccgttgagg
     2101 ataagatcaa aaaactgcca ccagaggagc agtttgcagc gattcgcaat gtctacgctc
     2161 agaaacaatc gattgccagc ctaactgaaa attatgacct gattatcaac cttgcagatg
     2221 tcaatacagg tgcaacagta cagcgcatcg tttggccagc ttcaaaagga acaccagaca
     2281 ttccgtttta tgtgcatgag gtgccaacca tttttgtttc tgttcaatcg ccttatcatc
     2341 tggcagatgt tccacaggtt ggaacttata tcaatgccta tgatggcaat cgggagaccc
     2401 tagaagaatt gactaagaag ctgatgggag agtcttcttt taaaggaatt gatcctgttg
     2461 atgcttactg tggcttgatc gatactcaca tttggcgaag ccactgagaa aggaattacc
     2521 atgtcaaaaa tagttgattt aacccaaaaa ccttacaatc ttagtccatc gcaaatcgct
     2581 tgggtggaag acactctggc tgatttgagc gatgaggaaa agatcggcca actctttgtc
     2641 aatctcttct tctttggcgg agatatgttt agtggcaata acttgagcaa tcaagaaatt
     2701 ctcaagaaat accacatcgg tggtgctcgt tatatgaatg ggacgcctga gcaagtacaa
     2761 ggactgatta acgaattgca agagcattcc aaagtgccgc ttctagttgc ggctaattgt
     2821 gattcgggtg gtgacggcgc tgttaaaggc ggaacctaca tttcctctgg cgcccagtca
     2881 gaggccagtc gagacacgcg tgtgccttat ctagccggtc ttgtttctgc tcgtgaggag
     2941 acagctctcg gtgttaatgt caattttgac ccttgtgtgg atattctaga aaactggcgc
     3001 aatacgattg tcaatacccg tgcttacggt acaacagcaa aagatgtgat cacctatacc
     3061 aatgcttatt tagatgggtt gacggctgaa agagaggtta tccagtgcat caagcacttc
     3121 ccaggtgatg gcaccgaaga gcgcgaccag cacttggtgt taggtgtgaa tgaactatcg
     3181 cctactgagt gggaggattc ctttggagaa gtgtatcgta accacataaa acgcggtgtt
     3241 gagatgatta tggctggtca tattgccttg ccacactatc aaaagcagct caatccagac
     3301 ctgaaagacg aggacatttt gccagcgacc ttggcgccag agttgatcaa cggccttttg
     3361 aagactgatt tagagttcaa cggtctggtc atcacagatg cttctcacat gttaggcatg
     3421 acagcagcca tgcgccgtga agactatgtg cctcaagcta ttgctgcggg ctgtgacatg
     3481 tttctcttct ttaacgatat ggaggaggat ttcaacttta tgctcaatgg ttaccgaaaa
     3541 gggattatca ctgaagagcg cttgaatgat gctgttcgcc gtatcttggg actcaaggct
     3601 aagctcaact tgcatgtcaa aaaggcagaa gggacgcttc tgaaatctgc tgaggagctg
     3661 tctatcattg gctgtgagga acatttggct tggcagagag aagctgctga taaggcaatt
     3721 actctgctca aagacacgca gaaaaatctg ccaatcagcc ctgaaactca taagcgcatc
     3781 cgcctttatt accttgaagg ggaaaaaggt gggattatgg aagctagcaa tgaggttgta
     3841 gataacttga aagctgcgct tgaacgtcgt ggctatgagg tgaccatcaa tgacggaaat
     3901 acccgcatta aaggcagcac cctcaagtat cgcgaggaag tagatctagc tttgaccgtg
     3961 gctaatgttg taggttatgg tgcgcaaaac aactaccgta tccaatggaa gatggccatg
     4021 tctaatgaag tgccttggta tgtccatgag gtgccgacaa tctttgtttc cctcaattac
     4081 acgacgcacc tgcacgatgc aactatggtt aagactgcta tcaacgctta tcaccacaat
     4141 cctaacacca ttgaatctct gattgataag ttagaaggca aatcagactt cgtaggtgta
     4201 ccaaatgatt tggtctgggc ggacaagtgg caagctaaac tatgattatt taaaagttcc
     4261 tactcaaaaa tcggacctgc ttaattaaac agatccgatt ttttgtcttt ttatattaag
     4321 aatatgaact tgcagataga actgaaattt actcagacga gttaacgatt ttcaaagagt
     4381 attaaattaa ttcttcaata ggaacatagt taaggcctaa atcacgagcg acgggttggc
     4441 tgacaagttt gccttggaaa gttgtagcac ctgctctcag gccatcattg ccattgagag
     4501 catcgataaa tccgagatta gctaagtcaa ggatataagg aagggtcaca ttagttagcg
     4561 caatggtaga tgtgcgagga acagcgccag ggatattagc aacagcgtag tgaaggacgc
     4621 cgtgcttgac gtagacaggc tcatcatgcg ttgttgtctg atctgcagtt tcgatgacac
     4681 cgccttggtc aactgccaca tccacaatca cagaaccagg acgcatcgtt ttgaccatat
     4741 cttctgttac aagtttaggt gctttagccc ctggaattaa gactgcaccg ataactaagt
     4801 cggactcttt cacgacttcc gcgatattga gcgggttaga catgagagtc tggatttggc
     4861 tgccgaagac ttcttccaat tcagataagc gtttagcaga gatgtccaaa atggtcactt
     4921 gagcgccgag acctaaggcg atacgtgcag catgagttcc tacaacgcca ccaccgatga
     4981 tggctacctt gcctttagga acgcctggaa caccgctaag aagcacacca gaaccgccct
     5041 cttgcctagt caagaagtgg gacccgattt gcaccgccat gcgtccagca acttcgctca
     5101 taggtgtgag aagggggagc tggccttggg cattcgttac agtttcataa gcaacgctat
     5161 tgaccttgct gaggagcatg gcttcagcta agtctggcgc agctgccatg tgaaggtagg
     5221 tgaagagaat taaatcttca cggagataag gatattcaga tttaagcggc tctttgacct
     5281 tgacaacgag ttctgcggcc cacgtctcag cagcacttgg agcaatctga gcgccttgag
     5341 cgacataatc tgcgtctgca aagccagatc caagcccagc ttgagtttca atcaaaacct
     5401 gatgtccagc ttgaacaagg gcgtaaacac cggcaggtgt caatgccaca cgattttcat
     5461 tgtttttaat ttctttagga ataccaatta gcatacgatt cccctttctt tctcatatat
     5521 ctattctagt ggaaaattga agcgatttca agttagagcc tgaaaaatga aaaactcata
     5581 acttacttta ggaagttgct caataaaaaa ttctaattga attatctaga tgaaatatga
     5641 aggaagtaat tatggtataa tataaattga taccttttgt attaaatgtt gaaaggttat
     5701 tgttattcag ttaataattt tatttgggaa acggttcatg ctttactact tacatttggt
     5761 tagtggacga ttgattgttc caaagaggta atgatgtata agattttagc cattgatgat
     5821 gataaagaaa ttttaaagct catgaagaca gctttggaga ttgaaaatta tcacgtaaca
     5881 atttaccagg aaatacaatt accaataaat gttgatgatt tcaagggtta tgatttaatt
     5941 ctcctagata tcatgatgcc tactattagc ggtattgaat tctgtcagaa aatccgtgaa
     6001 aaagtgtatt ctccaattat ttttgtcagt gccttagata ctgataagga aattattcag
     6061 gctctaaaca taggaggaga cgactttatc gtaaaaccat ttagccttaa acaatttaca
     6121 gctaaggtta actctcattt gaagagggag gagaggacaa aatcaaagag tgaaaaaaac
     6181 gcgagagaga agcgtagctt cccaccgata gaaatttatc tagaggaacg catgctgtat
     6241 attgagaagg aacctttgcc actgacatat cgagagtacg atattctaga gttactttca
     6301 cgtcatccgt ataaagtttt ctcgaaagaa gaaatatatg aacaagtata taatgaggaa
     6361 tcttcggctt tatttcattc tatttcagag tatatttatc aaattagaat aaaattttca
     6421 agttttggaa ttaatccaat aaaaacaatt cgtggagttg gttataaatg ggatgtttaa
     6481 aaaatattca ataagaaatc gtgtttggcg tacagttttt gaaattgccc ttggaacttt
     6541 tgttacaatt ttaatggttg taattatgtc actttctttc ttaaaactaa atatagtgac
     6601 atctcataat gttggagaaa ggtatcgtac tgaagataaa aagacagtca aacaactgac
     6661 aaactatatg aaatcattgg gattagatta tgtcattttt gataaagaaa caaataagat
     6721 tatggaaggg aagtacctgt ctaaagaaat ttctttgttt aaaaaagttg tcgaagaaaa
     6781 aagcaattta actttaaact cggtgcatta tgatttgtat acaaacaata attattatgt
     6841 tgttatcaga tataatgaga taccagaatt ctctaaccac tactttagaa atatttcgta
     6901 taatatgctt actttttatt ttctaggttt tggaatgagt attagtatca tagttgcttt
     6961 aacacggttt gtaaaagaaa tttctttaaa tttcaagaaa attaagagag cagccaataa
     7021 aatggggaga gatagcatat ctgaacaaga aagttattct aaaataatcg aatttgacga
     7081 tatcctgaga accttacatg caaaaggaga taacttgaaa aatttgattg atagagaaaa
     7141 attagaaaag caagatttat ccttccaaat tgctgcgctt tctcatgata ttaagacacc
     7201 gttgactgtt ctaaaaggaa atttagagtt actagaatta actgtcttat ctaccagtca
     7261 acaagattat acactttcta tgaataacag tatttcggtt cttgaaggat atttcaattc
     7321 tttaatttcc tatacacgaa tgctctcaga agagagacca gcgaaactga ttatcattga
     7381 gaagctatta aatgagttgc attttgaggt caacgacctt ttgaatatga acaaggttac
     7441 atattccctt tgtaatcgac ttacaagcac ttctttttat ggagatggga gccatttgat
     7501 gagggcactt tctaatcttt tagttaatgc aattagattt acgccagtat caaataagaa
     7561 aatagaggtc acattgtctg agtcaagcaa tcaaatttat tttgaaatat ggaacaatgg
     7621 tcagcccttt agtgaaaaca ctctgaaaaa tgggaataag ttattttata cggaagatta
     7681 tagcagagga agccagcatt atgggattgg attagctttt gtcaacggag ttgctactaa
     7741 gcatggtgga agcctccgat tgtttaatcc agctagagga ggagcgagtg caattttatc
     7801 cattaaaaag aacctccaga aactatgatg gaatttgaag tattttaagc agaaatcata
     7861 aagaattttt tgattatctg cttaaaatac tttttttctg aacaaattct gaacttgaaa
     7921 tgacataatg atagtgtaaa tatatcggtt acttaaatga aagcgaggaa gtggaaaatg
     7981 aagaacacaa ttaaagattt cgacctagat ttaaaaacaa ccaaaaataa ctctgctgaa
     8041 ccacttgttg gtagtcgcta tctttgcaca cctggttcat gttggaaatt agtttgcttt
     8101 acaacaacta ttaaataatt caattactat tattactgta gtttcaaata atccgatata
     8161 tttataagtt tagaggagta gactgttttt agtttgctcc tttattagta gataaggaag
     8221 ttatatatga ttaaagctca actgaagaac ttaatgaaga caatcaatct tgtaaaagaa
     8281 gcaggatttt cattgttaat gttctcaatt ggtattagtc tgtttcaagg gatcttacca
     8341 atttttagta tgctattagt gcaaaatatg ttaaatatta ttgcaagcaa tattgatcgt
     8401 tttcacacat tgatgatttc ttttaccctt tatgttattt taacattatt gactattata
     8461 gttggagaag tcgatgggta tattgatact aaattacaga tacttttgca ttataagatg
     8521 aatcatttgg tcatgcagaa aactgtaaag ttaacattag ctgaatttga aacaccagag
     8581 atatatgatg acattacacg tatacagaat caaatatcct ataaaccgtt tcaaatatat
     8641 aaatctatta tttctgtact atcttcatta gtattattta tttcttcctt tatcattctg
     8701 ttgaattgga agatatcaat ttttccactt ttgattgttc ttcctataat ttcaatttat
     8761 atatacttaa gaataggtaa aaacgaattt gaaatgttat atagacggag tagtgatgaa
     8821 agggcaaatt ggtatattag tcatatttta acacatgatt ttgctgttaa ggaattaagg
     8881 ttaggcatat tagaaaacta ttttttaaaa aaatttgaca aaaataatca attatttatt
     8941 agtcaggaaa atagtataaa taagtctaaa atgaaatatg gtatattatt gggaattttg
     9001 gagattactg tagaatcaat tataatgttc cttgcggtta gagaagcatt tttaggaata
     9061 cttttaattg gaaatgtaac gacttttata agatctttat ctacaatgca aacaagtaca
     9121 caaaatatag tgaacaatat ttattcttta tacaatggct cactgtacat ggagttactg
     9181 tatgatttta ctcatgatga gataggatac aataatctaa cagaaaatat agttgaggat
     9241 attcagtcta ttgagtttga acatgtttct ttttcatata atggtaagga aaatgtgata
     9301 aatgacataa gtttttcaat tacttcagga gaaaaactag caattgttgg tgaaaatggt
     9361 tctgggaaaa gtactatttt taaattagtc tgcggacttt atgataatta tgaaggaaat
     9421 atttatataa atggtataaa tcttcgttca atacagaaaa aatcatatta taagaggata
     9481 tcagcgttat tccaagattt cttgaaatat gagttgacac ttcgtgaaaa tgttggatta
     9541 ggtgagctat caaagttgta tagcgatgag gatttaataa gcacattaaa gcgtacggga
     9601 attgattcaa tattttatgc taagcaggaa aaaactaatc agctagactt agaacagcaa
     9661 ttaggaaatt ggttcgagga tgggagacag ctttctggtg ggcagtggca aaaaattgca
     9721 ttatcaagag tttatcttaa agaagctgat tgttattttt tggatgagcc tagttctgct
     9781 ttagatccag aatctgaaac aaaaattttt aaaacatttt ttgaattatc acaaaataaa
     9841 attggtattt tcattacaca taagccaagc attactcaat ttgtagatga aattttgtac
     9901 ttggaggatg gtggcgtagt cgagatagga aatttcaatg atttaaacac taaaggtatg
     9961 aaattcaaaa atttgttaga taaggagatt ggaattgtat atgacacctc aaattgaaca
    10021 aattttaggt tatgttgctg gtagtttcac gaactatgaa cgggtagtag cagaaagtgc
    10081 aaataaagcg ctaattaaca tagaacctaa ataccaaaat actttttttg agaaatcttt
    10141 aagtcacggt ataccatcat taatcttaat gtatagttca ctatataaag taacaaaaca
    10201 agagaaatat atagcgttgt ctaacataca cattgagaaa ttagttgaaa tcatctccaa
    10261 agatggcata gaatccccat ctctttatgc gggaactgct ggtatttcat tagctattag
    10321 agaagctagt atatcaggaa aatattatac aaagctgttg agctctttac attgcctgtt
    10381 gaaagaacaa actcaagaaa aattgattat aagtttatca aatattgata agaggattat
    10441 tgagccattt gactatgata tggttaacgg ttttagtgga atagttaatt acttaatact
    10501 tgagagagaa tatttttttg aagaattaaa acaaataggg acttatcttt tgaagtacgt
    10561 tgagacaatt ttgtataaag taacaaattg ttctgtagac acaaaaaatg aattagattt
    10621 gggtattgct catggaattg ttggcccaat gttaacatta gcaaaattaa aatcagaaag
    10681 aatcttaaaa gaagatgtag agatattgaa taaagctatt aagctagtgt tcttatgtag
    10741 aagagaagat aaactgtggc ctggaaaaat atattctgat aatattttga attttgattt
    10801 taaaaatctt cctactagga tggcgtggtg ctatggtact cctggaacag cactcgcttt
    10861 atttaaaata tgtcaattga tggatttaaa ctatactgat aatattgtcg aaagtttggt
    10921 tgctcagatg aacagtacag aaaaaaatat ttattcaccg tcaatgtgtc atggattatc
    10981 aggtgttgcc tttatatatg atttgattgg tagaagctat tcaaatgtgg aattagcaaa
    11041 ttttgcagat tacctacgcc aagaaataat aatgcaattc tcagagcaga aaatatttgg
    11101 atatactgat agagaaaaat taggggaagt agaagttgaa ctggagtcag ttggtatatt
    11161 acagggggtg tcaggcatag tcttattttt attaaatcct tatagtgatg aggaattgtt
    11221 gtgggaaaga atgtttattt aattaaaaga ggagaacaag atgtataata tatttccaag
    11281 aggtatgatc cgcattcctt tgcaaaaaca agaattttat aataaaggat atgaggaact
    11341 gataaatgat aaagttttta tggagcaact tctagttgct agtcctagtc tctataatag
    11401 tgtaataaat attgataaat gtaatgaaaa gaaaaaacaa aatgtaaaag tatcattaaa
    11461 gagttacgca aaaagagcag catttcggac aactccgttt ggaattttta ctgcaataaa
    11521 tgtagttgac ctaacgaatg aaaataactc taatgtgcaa aaaattagct ttgctaaaaa
    11581 agcagcacca gattatcttt gggtatattc tttagtgaaa tcttatgaaa taaagaatat
    11641 tgaaaagctt gactttaaga taaatacagc agcgtttatc caaggagata gatatgtatt
    11701 accatttaca gtgaatgagt ttgaggagga tagaaatata agccttttga agccagttca
    11761 gatattgatt gaaaaatgtc aaaaagacta tgtaagctat gaagcattga taaacatact
    11821 taaaaatagc tatccagagg tagctttaga agtactaaca tcatttatct acaatttagt
    11881 tgaaaatgat tttttaattt cagatttgag gccaccaatt tgtaatatta attccctaga
    11941 ttatttattg tcaaaattag aaaaaggaaa actaataaat gatttacata atttaaaaaa
    12001 tatgattgaa gattataatg atttaaaaat cggtgaaggt agtaatttac ttcttcgaat
    12061 ctttgatgtt atgaaaaata ttcataaata tgataatggt ggtaattatc taaaggtaga
    12121 ttccttagca aagtttgatg gtgattttga tatattgtca gaaaaatctt ctgaaactat
    12181 aaagcagttt gcaggaatgt ttgtaaagtt gaatgctagc gtaaagagaa gaggaggtcg
    12241 gaaaaattcg tttgaagagt atcaattgaa atttattgga aaatatggag aaaattgtgc
    12301 aattccattt gtagaagtaa taaataaaga tattggcata ggatttccgg aatattacaa
    12361 agatgaatca ggagaagaaa tagagttaag tgacccaata atgcaaatgt ttgaaaagaa
    12421 atatgaggat gctcttttaa atggtagtgg tattgaattt agctcaagag atttagatga
    12481 ttttgaaata gatcaaaata atagtttaga atcatttgag ttaaatttta atatcaaaaa
    12541 gctaaataat gatgtcaagt tatatttagg tgccaacatt ggttctggtc aggctggtag
    12601 aagtttcggt agattctaca cattaagcga acgattaaga acaacaatta aaaagttaaa
    12661 tcagcaaaat tgtatgaacg tagagttatc attcgttccg aagcagataa gaatagcgaa
    12721 tgtaatgcaa aattatagtg acgaatcctt taatacctca ttttttacaa catcatggga
    12781 ttcaacaaat gagattagat tagaagacat ttatataagg tatagtgaag gtaagtttca
    12841 ttttacaaca agagatgggg agaatgagtt aaaatttact atgaataata tgttgaattc
    12901 tgatagccaa agtaaggtac tgagattgtt ggttgatata tcagagtttg agtatggttt
    12961 atcacattgg tctttatttc cgtgggatat tttggctcag gaaagagtct atattcctga
    13021 aatttcattt gagggaatta cgatagctac tgcacaatgg aatttatcag tgatgagaga
    13081 acagctacta actcaaaata aatttactga taaaaaagtc atatttgata attttagaaa
    13141 gacatacaaa gttcccaagg acagcatttt gaaatatgca gataatgaat taaggctaga
    13201 cttatctatg gatgatgact tagagatttt atttaaaaat attaagaaat acgcacttgt
    13261 ttcactaaga gaaattgaga aaggggagtc aatttttaaa gaatatttgg gtaactacaa
    13321 cgcagaaata gtggttccaa tcattaaaaa cttaaataaa aaagtaagtc gcgaaactaa
    13381 ggtaatcttt aaaaatgaaa ttaagaaaac atatttacca ttttgtgact ggctattttt
    13441 aaaattgtat ggtccaaaag aacgacaaaa tgaactatta agttactgga accatttttt
    13501 tgcgaataga gtaccagaaa attgtaatca aaccaaaatg ttctacatga gatataatga
    13561 catcaatgat catgtaagaa ttcgcgtaaa ttgtaattca attgaaaata atttttcttt
    13621 gtatttgtca gtagttcatg atttattacc ccaactgata gaaaatggta ttatctctga
    13681 tatagaagtg agtagctata agccagaagt taatagatat ggaggacctg atttaataag
    13741 ttatgctgag gaaatttttt gtaaagaatc tattttattg atgaataata caatagaatt
    13801 ctcagataat gaaagattaa tttgtgccac ttatttggtt ttacactatc taaattactt
    13861 ctttaaagat aaagaaacaa ggctttcttt tctatttgag aattatactg gaaaatataa
    13921 aaaagaattt aaaaatttac caattgattt acctattgag tatatgaaga gcctgaatgg
    13981 agtagcctca gcgttagata aatatgattt tttccaggaa atggataaat atctcgcatc
    14041 ttatatggaa gaatacaatc aatttggtag ttcaaatact atttataata ctaaatttaa
    14101 tttagtagga agttttttgc atttatcaat gaaccgatta aacggaattg atagagaatt
    14161 tgaagagaag gtatattgtt ttgcttacta cacactaaat gctcaacagt atatataatg
    14221 ggagtgatta atatgttaaa agtacaaaac ttaaaaaaat cttatggtaa gagaactgta
    14281 ttagataatg tcaatatgaa tattcctaaa gggaaagttt atgctttaat tggtccaaat
    14341 ggtgctggaa aatcaactat aatgaaaatt ttgacaggtt taattaataa gacgagtggt
    14401 tctattatgt ttgaaggcag agagtggtca cgtcgagatt tgcgcaaaat tgggagtatt
    14461 attgaagaac caccacttta caagaatttg agtgcctatg ataatatgaa agtagttaca
    14521 acaatgcttg gtatttcaga tagcaccata cttccattat taaagaaagt tggtctgggg
    14581 aatattgata agagaccagt aaaacaattc tctcttggga tgaagcaacg gttaggtata
    14641 gctatctctt taataaattc acctaattta cttatattgg acgagcctac taatggtttg
    14701 gatcctattg gaattcaaga attgagggaa attatagaat catttaaatc agaaggaatg
    14761 acaatcatga tttcaagtca tattctttcg gaggttgaac atctggctga ttttattggt
    14821 ttcatctatg aaggaaagat tatcctagag aaagaatatg atggctctga gaatcttgag
    14881 caactgttta atggtctaat tttatctgag aggaggttag gttgactatg acgaaaatca
    14941 tactgtctaa tttactgaaa ataaaaaata caagtatcta taagttggtc tttctttttc
    15001 ccatcatttg catcatgtta tctttgttat tttctgcatt aggtggtgaa agtatcttac
    15061 gtctaactgc agaaacaaca ttgaaccaat ggggaattat ttggattaat gttattattt
    15121 cagttaattc tggactgtta aacaaacttg aaaaggattc taacaagtat tcgattttct
    15181 tatcaaggga cgttgattta aaaaaggtag aatatacaag agtcatattg atagctttta
    15241 tcaatttaac aattagcata atcttaggtt taatgcttgt ggtggtcagt ttagttatac
    15301 cgacacctag tatcacaagt ctggggagaa tattgctgac tatattatta ctttggttga
    15361 ctacgttatg gcaaattccg cttactttat ggctgtcaag aaaaactaat ttgtattttg
    15421 ttatgattat taatactata tctccactaa ttattggtac aagtttttct ctcttagata
    15481 aatggtattt gtttccttat gattggtcaa tgaagcttct tgagccgatg acaggcatga
    15541 ggataaatgg tattcctttt ggttctgatt ttattcctga ctattcactt gttttcatat
    15601 ctcttagctt aggtatcttt ttcttcattt tattaactga gctagctgct atatctttta
    15661 aaaggcaggt gagatagcaa tgaaatctta tttacaatct aatttcataa aaataaaaaa
    15721 cacgtcttat ttactagtgc acattttagc tacattatta tttccactac ttctattctt
    15781 ttactggatc cagcgtgggg atatacaaaa caatattgca ttgttttcct atttccaaat
    15841 agtaggagta cttcttccct ttgcctctag tattgtaacc attcagttaa agagtttaga
    15901 agaagaagca ggaaaattca agtatttgct tgggtattca ctgtcgagtt acatgccatt
    15961 ttttatagaa ttgatatttc tatggatgtg ctactgtata gtattactgg tttcttttgc
    16021 tctattcggc atctttgtga taatgagtgg tgcaatagta aattttcaag ttgttttttt
    16081 gaacatttca ttttatatca ttcttgcttt tgcgacatat ataataaatc atatcattag
    16141 ttatttatgt agtataggag tagcactagg aatttctatg ataggggtga ttgttgcggc
    16201 attttgcgaa acaagtctag gtgacaaggt atggtttttt attccatggt catggccttt
    16261 aagaatatca gatgtcttat tcaatcaaca gaaaatagct agcattcatc ttattgttat
    16321 ggctattatt tcgatcgcaa tgctcttgct ccataggcga gtatttcaga attggaatca
    16381 agatcgatta acggaaagct gagtatatct atttttgagt tttatttatc tgttaataac
    16441 aaataccatt ttttccaagt tataaagact ctctaattta tctgactaaa aataggtata
    16501 aattttaatc gaataatata gtgagttttt atgattttgt ccaaaggagc ctttttgtct
    16561 taggctcttt taattttcct ctcatttctt ctaccgatag agtcacctgc cataatatta
    16621 agaaggaggg aattcagtaa cttcctacag taagttccac tagtggttta gatggacgtc
    16681 agtctgggag aaattgctct tgcgacatgc gtgaaaaatt gagtcaagct attgacagtc
    16741 tatagactct atgatatact tttcaagtac gctgatttag ctcagtcggt agagcgcatc
    16801 catggtaagg atgaggtcgc cggttcgatc ccggcaatta gcatttcccc cagccctgag
    16861 atgtttgtct cagggctttt tccaataata caataggata ggagtttcta tatgaaaaaa
    16921 gtatgttttg tttgcttggg taacatctgt cgcagtccta tggctgagtt tgtcatgaag
    16981 tctttgacag atgagttaga gattgagagt cgcgcaactt ctggatggga gcatggtcat
    17041 ccgattcatg agggaactca gggcatttta aaacagtacg ggattgctta tgatgtgaaa
    17101 aaagattcga caaagatgag ttcagatgac tttgagtatt ttgatgtaat tatcggtatg
    17161 gatgcttcaa atgttgaaaa cctcaaagcc atgtcagatc ctaaatacca taacaaaatt
    17221 gtccaatttg cagaagaatc ggtccctgat ccatggtaca cgggtgactt tgaagatacc
    17281 taccaacgtg tcctgtctgg atgtcaagaa tgggtaaaaa aattgacata aaactgtcat
    17341 ttatctcaaa aacgctctaa aatatagtat aatggttagt atataggagc aaaagagaca
    17401 tatggaattg attcagtatt attacgagcg cttaaaacca catttgcatc ggcgaaattt
    17461 agaaatggct gctgcgggat tagttgtcct atgtggttta tttgtggtat tgtctggttt
    17521 tccaaaaacg gtgaagacta gctacaaaga tggggctatc gtctatgaag ggcaagttgt
    17581 ccgccagaaa atgaatggac aaggcaagct gaccttttca aacggtgatg tctacaaagg
    17641 aaatttttcc aatggaacct ttcaaggcaa gggcaagttc accgctaagt ctggctgggt
    17701 ctatgagggc gactttgtca atggtgtcgc tcatggccaa ggaaagttaa caacagaaaa
    17761 tggtgttgtc tacgaaggca agttcgagaa gggagcctat caggatgcga attaaatggt
    17821 tttcactcgt ccgaatcttg gggatgagca tggttttgct ctatcacttt ctgccaagtg
    17881 tttttggagg cggttttttc ggggtagata tttttctcgt tttttctggt tttctgacaa
    17941 cagctatctt tttagatgaa tttggaaaga cagatgctat tgatctcgtt ggcttctata
    18001 gacgtcgtct gtatcggatt ttgccgcctg ttctcttgat gatcggagtg gttctgcctt
    18061 taacgcttct tattcgtagt gactttaggg cgggtatcgg ctctcaaata gccgcagcca
    18121 ttggttttat caccaattat tttgaaattg cacagggtgg ttcttatgaa aaccaatttg
    18181 tgccccatct tttcgttcac acgtggactt tgggcataga agttcagctt tacctcttat
    18241 ggggagctct aacctgggga ttgagccgtg ttgctaagag caaggagcag tttcgagcct
    18301 atctgtttgg cttatcgagc cttttcttct tggtgatgtt tggaaggttt atctggagca
    18361 gttttaatgc tgataatctt tcagctattt actatgcaac tggcaagcat ggcttcacct
    18421 tttttatcgg agcgattcta gcgaccttat caggtattgg acagacgaca gccgctttta
    18481 aacaattgag ccagaaattg gatacgaaaa aggtatttgg tggcatcttg cttgctcttc
    18541 tggttttggg aattttaaca cttgtcctga cttttgagaa cttatggact tactggattg
    18601 gttttatcct ggccagcctt gcagcagtag cgcttatttt ggcttttcgt gtcctgcatg
    18661 agaagacacc gaatatcgct gaaccaggtg tcctaatttt tctggcaaat atcagctatg
    18721 gtgtttatct ctttcattgg ccatttttca tcattttttc tgaaatgacc aacaaagggg
    18781 tggcgattgg gctgacattg ctcttatcag tggcctttgc gagcttgtct ttctacatac
    18841 tggagccttt agtgatggga agagctgtca agtttgctgg ggttgaactt gatttaacca
    18901 gcgctaaaaa acctctagcc attgttgcag gcgtctttgc tctctttgct ttaggtctat
    18961 cgctcttttc tcctcgtatt ggtgctttgg aaaaagactt gatgatccaa ggtctagagc
    19021 aagctgacac taaaatggca cagacccgtc agattgttga tggcagaatt gcttctgact
    19081 atggtgttta tgaaggaacg cttgtcattg gggattcggt agctttgcga gctagtgatg
    19141 gtctgactga tgcgattgac ggtgttgtcg tggaaggaga agttagtcgt acgcttgagg
    19201 gagcttatgc ctttttgcaa gaaagcatta aaaatcgcac tctacctaga gatgtcgtga
    19261 ttgccgcagg aaccaatacg attgcaaact atgaggaagt attagataac attattaaag
    19321 cagtacctca agggcatcgt ttgattttgg tgacgcctta cgatggtcga gtggccggaa
    19381 atcctgcatc tcttgcgaat ctgacgagag attatgaatt aaaattagct gaaaaatacg
    19441 actgggtgac tgtagctgat tggtacaaag ttgccatcaa ctccccacaa atctggcatt
    19501 ttacagatta tgttcatttt ggaaatgaca gtgacagtat ccgagaagga caagaaatct
    19561 atgccaaaac agtaacagat gctcttgcaa aagctagtaa gagctctgtc agattgacca
    19621 ccaagtcaga atagtcagcg tcaaaaggta tcgtcagtcc attttaaagc aatctaaaaa
    19681 atatttggtt agttgctcaa ggacacgctt tcgaaaattt ctgtaaaact agtataatag
    19741 attgaaacaa gattagggca aacttgtctc aaaatcagag cttcatctag tatgcttttc
    19801 tgaaccgaag ttatatcgtt cttgattcca ttgactatca aacatgtttt aaagtaaaaa
    19861 aactataaaa agattcgcac aggaggctta attcgtgcga atcttttgtt tatcattata
    19921 aggggttttt atttggaata cctgccttgc gcgggtattt tttgggtgtc tcttttttct
    19981 tttcgaccaa agtgatgttt cgaggatcac cattaggaag ccggtaatct ttagaaagga
    20041 ctatgtggca gaagagggta ttgagggcat ttttagcagc aaggttttct tcttcggcag
    20101 aactggcctt tagagcaatg agttgcccct tgattttgag aaagggaatg gtcagttcac
    20161 tgaggacttg catacgggcg acagctcggg ccgtaaccag atcaaattgg gctctaaagg
    20221 taggttgctg ggcaaaatct tctgcccggc catggagaaa atgcaccttg gctaagccta
    20281 gttcatcagc tagatagttg agaaaggtaa tgcgtttatt cagcgagtcg ataatggtca
    20341 catcaagctc aggacagagt atcttcatgg gcaggctagg aaagcctgcc ccagctccga
    20401 tgtccaaaag atggataggt tcattaaaaa tcaatccttg taagacaggt gccagcgagt
    20461 cgtagaagtg tttgaggtag acctcttctt tgtctgtgat ggctgttaga ttgattttgg
    20521 cattccattc gacgagcagc tcaaaatagc gctcaaactg gactttttgc tgacttgtca
    20581 gttcaaaccc ttgctcagct aaaagcttgt aaaatagttc tggtgtcatg gggcgtcctt
    20641 ttcttgtaaa ctatacccat tttatcataa atttaaggaa atttgatata atagaaataa
    20701 taactgagca gatttagcaa atttagctag gctttggtag ctaaatttgt cacttcaagg
    20761 ctcatttaaa ctcatcaaag gagacgttat aatggcattt atcgttagtc tgattatttt
    20821 agttgttttg gttgcttggg gtattggcat gtacaatggc ttggtgcgca gtcggatgca
    20881 caccgaagag gcttggagcc agattgacgt gcaactcaaa cgccgtaacg atctaattcc
    20941 gaacttgatt gaaacggtta aaggatatgg acgttatgag caagagacac ttgaaaaagt
    21001 gatcaaattg cgtaaccaag ttgctagtgc tagcaatcct acagaaaaaa tggcagctag
    21061 tgacgaatta acacgtcaag tctcaggctt gatggctgtt gctgaagcct atccagacct
    21121 caaagcctct gctaactaca ccaagttgca ggaagaattg accaatacgg aaaacaaaat
    21181 tgcctattca cgtcagctat ttaactctac tacagggaat tacaacgcca aattgcagac
    21241 gtttcctagc aacctttttg cgaaattctt tggttttcaa ccaagtattt tcctagcgat
    21301 tcctgaggaa gaaaaagtgg ttccaaaagt tgactttggc ccaaacggtt taggagacta
    21361 gtatgttatt tgaccaaatt tcagctaata aacgaaggac catcgtcctc ttgttggcct
    21421 tctttagctt gctagccttg gtaggctacg gtgtgggcta tctctggctg cagtctggtc
    21481 ccacaggtac aatcctagct ttagttgtcg gtttggttta cgctttggcc atgatttttc
    21541 agtcgactaa tgttgtcatg tctatgaata atgctaggga agttacggct gatcaagcac
    21601 ctgaacttta tcatatcgta gaagacatgg ctttggtggc caaagttcca gtaccaagag
    21661 ttttcatcat tgaagacgat gctctcaatg cctttgcaac gggttccaaa cctgaaaatg
    21721 cagcagtcgc tgcaacgaca ggtcttttgc gggtcatgaa tcgtgaggag cttgaagctg
    21781 ttatggggca tgaaatcagc cacattcgaa attacgacat ccgaatttca accatagcag
    21841 tagcgctcag ctcagccatc accatgctgg cttcgatgag tcagaggatg atgtggtatg
    21901 gtggcggaag aagccgcaga cgagatgata gagatggtgg agatggcgtt caagttatga
    21961 ttctagtatt gtctctgtta gctgttgttt tagctccctt ggcggcaacc ttagtccagc
    22021 ttgcgatttc tcgccagcgg gaatacttgg ctgatgcctc atcggtagaa ttaaccagaa
    22081 atccagaagg catgattaga gcccttcaaa aattggaaca gagcaagccc atgtcgcaac
    22141 ctgttgatga tgccagcgca gccctttaca tcaacgatcc gatgaaaaaa ggtagcctgc
    22201 aaaaattgtt ttacacccat ccaccgattg cagatcgcat tgcccgtctg cgtcaaatgt
    22261 aaggaaaaag atgtttcatt tattagatat taaaaaaaat ccagaaggtc tcagtttctc
    22321 agaaaagcta gaccttaaag cgaacttaca gtcccgcaat cctgagatcc tcaatattga
    22381 ggaagtcacg gcaaatggtc aggtcaaata tgaaaacaag atgtacttct tggattattc
    22441 cttgtcctac aaactgacct tgccatcaag tcgctccatg gagcctgtct tgttagagca
    22501 atcttatcca gtcacagaga tctttatgga agaggcagac ctcagaaact tagcaggaga
    22561 tattgatgag gagctagtct tggtcattga gggggagcag attgacttgt ctgaaagtgt
    22621 tgcggataat atcctgctca gcattcctct caaggtcttg acaccagaag aagaagcctc
    22681 agcggctttt ccagaaggag aggattggca agtattgtca gaagaggact acgctgctag
    22741 tcaagcggag caaaaaaagg ctaattcgcc gtttgcaggc ttggcaggac tatttgaaga
    22801 atagggacga aaatttagaa tatttaaaga ttcttgaaat gacctcccct aaagtgtata
    22861 atagagtaac tttcgaatga taagtgaatt cgacctaaat ttctagtgaa gagtcgtaaa
    22921 gtttctagag tcaatggcgt gagcagcaaa aatcggtgat ttaaggaact gcttaggcaa
    22981 tctgccttgc tgcgaggcta ggacaggctg ctatcatagt gaactgtcct gcttctcggc
    23041 ttagcgtctt acgatttgtt atcgcttttc ccgttttcac atggaacttt tatgggcacc
    23101 tatcttaata aaggagtatg atttaatgac aaaagcaaat tttggtgtag ttggaatggc
    23161 cgttatgggc cgtaacctag cacttaatgt ggaatcacgt ggctacaaag tggccattta
    23221 taaccgttca agcgataaga ccgaggatgt tgttgctagc aaccctggta aaaacctttt
    23281 gccaagctat gatgtggaga gttttgtcaa ctctattgaa aaaccgcgtc gcatcatgct
    23341 gatggtgcag gctggtaaag ggactgatgc gacaatccaa tccctcctgc cctaccttga
    23401 taagggtgat atcttgattg atggtgggaa tacttacttt gaagatacta tccgtcgctc
    23461 caaggaattg gctgactcag gcatcaactt catcggtacg ggcgtatctg gtggtgaaaa
    23521 aggagcactt gaaggccctt ctatcatgcc tggtggccaa aaagaagctt acgagcttgt
    23581 tgctgatgtc cttgaggaaa tctcagcgaa agctcctgaa gatggtgctc cgtgtgtgac
    23641 ctatattggt ccagatggtg ctggtcatta tgtgaagatg gttcacaatg gtattgagta
    23701 cggtgacatg caattgattg ctgagtccta tgatttgatg aaacacttgc ttggtctttc
    23761 gacggaagaa atggctgatg tctttaccga gtggaataaa ggcgaattgg acagttacct
    23821 gattgaaatc acagctgata ttttgacccg taaggatgac gaaggccaag acggcccaat
    23881 tgttgattac attatggatg ctgctggaaa caagggaacc ggtaaatgga ccagccaatc
    23941 gtccctcgat ttgggtgtac cactatcttt gattacggaa tccgtctttg cgcgttatat
    24001 ttcaacttac aaagaagagc gcctcaatgc tagcaaagtg cttccagcgc cagctgcata
    24061 caactacgat ggtgacaagg ctgagttgat cgaaaaaatc cgccaagccc tctatttctc
    24121 aaaaatcatg tcttatgcac aaggctttgc tcagctgcgt gtagcgtcta aggaaaataa
    24181 ctggaacttg ccgtttggcg agattgcttc tatctggc
//
