LOCUS       NZ_LT906439            23359 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Streptococcus merionis strain NCTC13788 chromosome 1, complete
            sequence.
ACCESSION   NZ_LT906439
VERSION     NZ_LT906439.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus merionis
  ORGANISM  Streptococcus merionis
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Streptococcaceae; Streptococcus.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (19-JUN-2017) WTSI, Pathogen Informatics, Wellcome Trust
            Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900187085.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 13:40:18
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,228
            CDSs (total)                      :: 2,160
            Genes (coding)                    :: 2,111
            CDSs (with protein)               :: 2,111
            Genes (RNA)                       :: 68
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 27 of 49
            Pseudo Genes (incomplete)         :: 28 of 49
            Pseudo Genes (internal stop)      :: 10 of 49
            Pseudo Genes (multiple problems)  :: 16 of 49
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:09:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 115986
            Orig. end                         :: 139345
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LT906439.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23359
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="2"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..23359
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23359
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13359](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13359
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            384..899
                     /gene="lacB"
                     /locus_tag="CKV83_RS00540"
                     /old_locus_tag="SAMEA4412692_00109"
     CDS             384..899
                     /codon_start=1
                     /gene="lacB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012027025.1"
                     /locus_tag="CKV83_RS00540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00109"
                     /product="galactose-6-phosphate isomerase subunit LacB"
                     /protein_id="WP_018373003.1"
                     /transl_table=11
                     /translation="MKIAVGCDHIVTNEKIAVVDYLKTQGYDVIDCGTYDNVRTHYPIF
                     GKKVGEAVASGQADLGVCICGTGVGINNAVNKVPGIRSALVRDMTSAVYAREELNANVI
                     GFGGKITGGLLMTDIIEAFIHTEYKPTEENKALIDKIAKVESLNQEQADPHFFDEFLEK
                     WDRGDYHD"
     misc_feature    complement(403..418)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.68"
                     /tool="antismash"
     gene            912..1844
                     /locus_tag="CKV83_RS00545"
                     /old_locus_tag="SAMEA4412692_00110"
     CDS             912..1844
                     /EC_number="2.7.1.144"
                     /GO_function="GO:0009024 - tagatose-6-phosphate kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262465.1"
                     /locus_tag="CKV83_RS00545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00110"
                     /product="tagatose-6-phosphate kinase"
                     /protein_id="WP_018373004.1"
                     /transl_table=11
                     /translation="MILTITMNPSMDIAYQLDGFCLDTVNRPLETYKTAGGKGLNVTRV
                     LSQLGESVIASGLLGGKIGEFIQEELDKVTIAHDFYPISGDTRSCIAMLHGEQQTEILE
                     KGPTILKSEAQGFLEKFEERVQTVSIISISGSLPNGLPVNFYEKIITICQKYDKPIVLD
                     SSGDSLKSVLTSEQKPTVIKPNREELSQLLGRNITGDIASLKKALQEELFNGIEWVIVS
                     LGANGAFARHIDRFYKVSIPKIEVVNPVGSGDSTVAGITSALAHAASDEDLLKKSNVLG
                     MLNAQEKQTGYVNMENYAALFEKIKVEEV"
     gene            1847..2827
                     /gene="lacD"
                     /locus_tag="CKV83_RS00550"
                     /old_locus_tag="SAMEA4412692_00111"
     CDS             1847..2827
                     /EC_number="4.1.2.40"
                     /GO_function="GO:0009025 - tagatose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000244542.1"
                     /locus_tag="CKV83_RS00550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00111"
                     /product="tagatose-bisphosphate aldolase"
                     /protein_id="WP_018373005.1"
                     /transl_table=11
                     /translation="MVLTEQKRRYMEKLSDENGIISALAFDQRGALKRLMAQHQDDEPS
                     VAQMEELKVLVAEELTPFASSMLLDPEYGLPATKALHKGAGLLLAYEKTGYDTTSTKRL
                     PDCLVDWSVKRLKEEGADAIKFLLYYDVDSDEATNRQKQAYIERIGSECTAEDIPFYLE
                     ILAYDEKIADASSADYAKVKPRKVIEAMKVFSDERFGIDVLKVEVPVNMNFVEGFANGE
                     TVYTKEEAASYFKQQNDATPLPYIYLSAGVSAKLFQDTLVFAKASGANFNGVLCGRATW
                     AGSVKAYIEKGEAAAREWLRTTGFQNIDELNKVLKETATPWTARV"
     misc_feature    complement(2888..2903)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 25.08"
                     /tool="antismash"
     gene            3311..4144
                     /locus_tag="CKV83_RS00555"
                     /old_locus_tag="SAMEA4412692_00112"
     CDS             3311..4144
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373006.1"
                     /locus_tag="CKV83_RS00555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00112"
                     /product="PRD domain-containing protein"
                     /protein_id="WP_018373006.1"
                     /transl_table=11
                     /translation="MYRVLQALNNNVALVKDEHNQQFVVMGLGITFQKRKGDLIIEEKI
                     EKVFSLKSTESRENFMTLLKDVPLDFITVTYDVIETLSDKYDYPFQEYLYVTLTDHIHC
                     AYRAVLDDNYQESKLPNISQEYSIEYVMAKEALAMFRQKILDDFPDDEIGRIALHFINA
                     KGVTAVEKTPKVKLTRSVLKKVQEELERLGIRRTRENSNFYDRLMIHLTYFLQYLDRSP
                     NENAPLMDMGKHIQIAYPEAYDIGSKIYEMIASEAGVEIYESEKFYIVLHIQRLL"
     gene            4171..4488
                     /locus_tag="CKV83_RS00560"
                     /old_locus_tag="SAMEA4412692_00113"
     CDS             4171..4488
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373007.1"
                     /locus_tag="CKV83_RS00560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00113"
                     /product="PTS lactose/cellobiose transporter subunit IIA"
                     /protein_id="WP_018373007.1"
                     /transl_table=11
                     /translation="MNREEITLLGFEIVSYAGEARSKLLDALKAAQNGEFEKAEELVES
                     ANSSIVEAHHAQTSLLQKEAAGEDLAFSVTLMHGQDHLMTTLLLKDMMKHMIELYKRGT
                     N"
     gene            4488..6182
                     /locus_tag="CKV83_RS00565"
                     /old_locus_tag="SAMEA4412692_00114"
     CDS             4488..6182
                     /EC_number="2.7.1.207"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0019197 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase complex [Evidence IEA]"
                     /GO_function="GO:0015155 - lactose transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373008.1"
                     /locus_tag="CKV83_RS00565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00114"
                     /product="lactose-specific PTS transporter subunit EIIC"
                     /protein_id="WP_018373008.1"
                     /transl_table=11
                     /translation="MDKLIAQIEKGKPFFEKLSRNIYLRAIRDGFIAGMPVILFSSIFL
                     LIAFVPNSWGFYWSDDVVAFLMKPYGYTMGILALLVAGTTAKSLTDSVNRDLEQTNQIN
                     FMSTMLASVCGLLILAADSLEGGFANGFLGTKGLLSAFLAAFITVAVYKFCVKNNVTIR
                     MPEEVPPNIAQAFKDVFPFAGTILSLYALDLLARNTVGTGVAEAIGKFFEPLFSAADSY
                     VGITIIFGAFAFFWFIGIHGPSIVEPAIVAVTYANAELNLGLLQAGQHADKILTSGTQM
                     FIVTMGGTGATLVVPFMFMWLCQSKRNRAIGRASVVPTFFGVNEPILFGAPLVLNPIFF
                     IPFIMAPIVNVWLFKFFVDTLGMNSFTANLPWTTPAPLGLVMGTNFQVLAFVLAVTLIV
                     VDTLIYYPFLKVYDQQILAEEQTGLASNDALKEKVAANFNTKKADAILEKAGVVEAKEI
                     TEQTNVLVLCAGGGTSGLLANALNKAAKEYGAPVTAAAGSYGAHREILPQYQLVILAPQ
                     VASNYEDMKLETDKLGIQLAKTEGAQYIGLTRDGQGALDFVKQQLAN"
     gene            6241..7647
                     /gene="lacG"
                     /locus_tag="CKV83_RS00570"
                     /old_locus_tag="SAMEA4412692_00115"
     CDS             6241..7647
                     /EC_number="3.2.1.85"
                     /GO_function="GO:0033920 - 6-phospho-beta-galactosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019512 - lactose catabolic process via
                     tagatose-6-phosphate [Evidence IEA]"
                     /codon_start=1
                     /gene="lacG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002290548.1"
                     /locus_tag="CKV83_RS00570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00115"
                     /product="6-phospho-beta-galactosidase"
                     /protein_id="WP_018373009.1"
                     /transl_table=11
                     /translation="MTKTLPKDFIFGGATAAYQAEGATKTDGKGPVAWDKYLEDNYWYT
                     AEPASDFYNRYPVDLKLAEEYGVNGIRISIAWSRIFPVGKGQVNPKGVAYYHKLFTECH
                     RRGVEPFVTLHHFDTPEALHSNGDFLNRENIDHFVDYAAYCFEEFPEVKYWTTFNEIGP
                     IGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVAHARAVRLYKDKGYTGEIGVVHALPTKY
                     PYDPENSDDVRAAELEDIIHNKFILDATYLGHYSDRTMEGVKLILEANGGELDLRDEDF
                     EVLKAAKDLNDFLGINYYMSDWMQSFDGETEIIHNGKGEKGSSKYQIKGVGRRQAPTNI
                     PKTDWDWIIYPQGLYDQIMRVKNDYPNYKKIYITENGLGYKDEFVDNTVHDNARIDYVK
                     KHLDVISDAITDGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAHWY
                     KKVAETQVIE"
     misc_feature    complement(7845..7863)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.52"
                     /tool="antismash"
     misc_feature    7875..7886
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.53"
                     /tool="antismash"
     gene            7917..9431
                     /gene="glpK"
                     /locus_tag="CKV83_RS00575"
                     /old_locus_tag="SAMEA4412692_00116"
     CDS             7917..9431
                     /EC_number="2.7.1.30"
                     /GO_function="GO:0004370 - glycerol kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006072 - glycerol-3-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="glpK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1210: glycerol kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003052247.1"
                     /locus_tag="CKV83_RS00575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00116"
                     /product="glycerol kinase GlpK"
                     /protein_id="WP_018373010.1"
                     /transl_table=11
                     /translation="MSKEKYIMAIDQGTTSSRAIIFNKNGENVASSQKEFPQLFPQAGW
                     VEHDANQIWNSVQSVIAGAFIESGIKPSQIEAIGITNQRETTVVWDKKTGIPIYNAIVW
                     QSRQTAPLAEKLKKEGYVDFFHKKTGLVIDAYFSATKVRWILDHVSGAQERAEKGELLF
                     GTIDTWLVWKLTDGRAHVTDYTNAARTMLYNIKELKWDDDILDLLNIPKAMLPEVKSNS
                     EVYGYTRPYHFYGGQVPISGMAGDQQAALFGQLALEPGMVKNTYGTGSFIIMNTGEDMQ
                     LSENNLLTTIGYGVNGKVFYALEGSIFIAGSAIQWLRDGLRMIETSPESEGLAAASGND
                     DEVYVVPAFTGLGAPYWNSNARGSVFGLTRGTSKEDFVKATLQSIAYQVRDVIDTMKID
                     SGIAIPQLRVDGGAAMNDFLMQFQADILGIDIARAKNLETTALGAAFLAGLSVGYWKDL
                     DAIKELNETGQLFEPSMDESRKEQLYKGWKKAVKATQVFADIDEED"
     gene            10001..11206
                     /locus_tag="CKV83_RS00580"
                     /old_locus_tag="SAMEA4412692_00118"
     CDS             10001..11206
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.5"
                     /locus_tag="CKV83_RS00580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00118"
                     /product="PqqD family protein"
                     /protein_id="WP_018373012.1"
                     /sec_met_domain="PF05402 (E-value: 1.9e-12, bitscore: 44.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4.1e-09,
                     bitscore: 33.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYIITCTKASLRYRWESEVLLTNLQKHGSYDIIFLLYGEDRSMGP
                     YLQEKYGISYYHFEDNRSQKQYPTSIRPYLWYQFLSQHPQMEKEVFFYIDTDIIFREMI
                     AFDKIPVDAQNWYGADSYCVKASYLRAKHPLYLQGLQTILSVTDEELKWTEDSPAGAQW
                     LIAQPTAAFFNEMYVHCERVYDFLVTMERIPHLQKEERLEEYGKWLTDMWCMAWLAPKY
                     GITVHISSELDFSWPTYSAEHWERYKILHNAGVTSENADAFYKAKWTHIPPFFFNHDNV
                     SSKLGSIYYVKAVQAVTIRPQDYDKVKILGTFITNQVKDTYIAIPLDEAKQKVSGYIEL
                     NDSSYLLWTLIQEKGSIQEIIEAYSQTFEIEKDQAKQDLFDFIAYLDTMKIIQFECGVS
                     TD"
     misc_feature    complement(10023..10043)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.86"
                     /tool="antismash"
     aSDomain        11006..11179
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CKV83_RS00580_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.40E-11"
                     /identifier="RREFam002.1"
                     /label="CKV83_RS00580"
                     /locus_tag="CKV83_RS00580"
                     /protein_end="393"
                     /protein_start="335"
                     /score="33.4"
                     /tool="antismash"
                     /translation="GYIELNDSSYLLWTLIQEKGSIQEIIEAYSQTFEIEKDQAKQDLF
                     DFIAYLDTMKIIQ"
     misc_feature    complement(11262..11278)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.12"
                     /tool="antismash"
     misc_feature    complement(11301..11316)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 25.31"
                     /tool="antismash"
     gene            11460..12131
                     /locus_tag="CKV83_RS00585"
                     /old_locus_tag="SAMEA4412692_00119"
     CDS             11460..12131
                     /EC_number="2.7.7.-"
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014409.5"
                     /locus_tag="CKV83_RS00585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00119"
                     /product="acylneuraminate cytidylyltransferase family
                     protein"
                     /protein_id="WP_051071081.1"
                     /transl_table=11
                     /translation="MTAQSFIAIITARSGSKALPNKNIQKVGNRTLIEITAEEALASGI
                     FSEIVFSTDSEEYAEILRPYGVTIDLRPQYLAEDTTPHLDTLRYVLRRYPDHQDYMLLQ
                     PTSPFRRAEHMIEAYKLYQTGQFDSVVSFTQVDKPTRLITRLVDDKPVDIYGNDKAYTR
                     QGQEKEYTTNGAIYISSKGNYLKKGSYLDEHCGVYLMNKRDSLDIDDEIDLLLANVLNN
                     Q"
     gene            12336..13088
                     /locus_tag="CKV83_RS00590"
                     /old_locus_tag="SAMEA4412692_00120"
     CDS             12336..13088
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CKV83_RS00590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMEA4412692_00120"
                     /product="hypothetical protein"
                     /protein_id="WP_018373014.1"
                     /transl_table=11
                     /translation="MERFRIGLAGLVIQITCRFDSTRIFCKDYLTDAEPDFEINVEQKD
                     IDFERARGGEKARHFSGNYLEQIALYRLICEVLPAYDRLLIHGSAIVLDDQAYLFTAPS
                     GTGKSTHSQLWLKVFGDRARILNDDKPLLHITGEQILIYGTPWDGKHSRSYNGSAPLEA
                     ICFLNQGLENAAIRLSETVAFDALVTQTYRPLQSIDQLKKTLALLQKVSHLPTYQLTCT
                     ISTEAVDVIYEKMTHKNHSNKINNNEEK"
     gene            13090..13359
                     /locus_tag="CKV83_RS00595"
                     /old_locus_tag="SAMEA4412692_00121"
     CDS             13090..13359
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.5"
                     /locus_tag="CKV83_RS00595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00121"
                     /product="PqqD family protein"
                     /protein_id="WP_018373015.1"
                     /sec_met_domain="PF05402 (E-value: 1.6e-10, bitscore: 38.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.3e-08,
                     bitscore: 31.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLKEGILRHHDRNDEYIGVTTGDLAETFNGMIRYNTTTHFILEK
                     LQADTTKEELITSLCQEYDVTPTEASADLTPLLQELTTLGLLEK"
     aSDomain        13192..13353
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CKV83_RS00595_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.70E-10"
                     /identifier="RREFam002.1"
                     /label="CKV83_RS00595"
                     /locus_tag="CKV83_RS00595"
                     /protein_end="88"
                     /protein_start="34"
                     /score="31.8"
                     /tool="antismash"
                     /translation="YNTTTHFILEKLQADTTKEELITSLCQEYDVTPTEASADLTPLLQ
                     ELTTLGLLE"
     gene            complement(13528..14454)
                     /locus_tag="CKV83_RS00600"
                     /old_locus_tag="SAMEA4412692_00122"
     CDS             complement(13528..14454)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019535.5"
                     /locus_tag="CKV83_RS00600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00122"
                     /product="glycosyltransferase family 52"
                     /protein_id="WP_018373016.1"
                     /transl_table=11
                     /translation="MKKYICFTNMQVMISLMKKQKGESIALFLHFNVRGHQELAERIKA
                     FFPDIWVEILTGKIIQTKQYFDWLEEEDHVYLFNDADQVGQEFRDRKYPYHLIEDGLNF
                     HYHYAQLAGLSDVDSSLEHYGFNPACLDIEVNDISKIKDNSFYARFLDKFIEVPRRELF
                     ERQEETHLKKLFALYQVEDINLISPSYLILTQPLADDFWSTFKKEDKSPDYAKQYYFYF
                     KMAQEAKEAGYHVYLKPHPRDDLDYHGIPEVTILPRYTPMEMIDLRLSTSFDVAATLMS
                     SSIEGITKVKEKRVIYTEQLTNSQNRP"
     gene            complement(14478..15587)
                     /locus_tag="CKV83_RS00605"
                     /old_locus_tag="SAMEA4412692_00123"
     CDS             complement(14478..15587)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.5"
                     /locus_tag="CKV83_RS00605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00123"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_018373017.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 8.5e-36, bitscore:
                     120.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSKTHEDIIYLLRYYLQRKPINHDIIAKMNLENLAQFAQFHSLS
                     AMVAMILEDYIELPKELQEAKNQGIRRELLFDHERQKITQWLSRSGIWYMELKGILLKT
                     YYPKLGMREMSDNDILFDESFQKEVKHFFTEEGYSFTYEINVDAYMKKPIFHFEMHRKL
                     IDPLSRIDSDYYDDVKSRLLPDQDRPFAYHFSLEDFYLYQMLHDYKHYSQSGTGIRSLV
                     DLFLFLETEYDNLDWSYIKKELFKLNLTDFEQQQRKLAFKLFGAHAVSLTDLTDDDRNV
                     LSYMLSSGTYGLMENQIINEVNYSNGNQWLYWKERFFPPVKTMQLRFPTLQKHRYLLPL
                     FYLYRLIPTSKRWRNFSLAVCLLSRKKEK"
     gene            complement(15599..17302)
                     /locus_tag="CKV83_RS00610"
                     /old_locus_tag="SAMEA4412692_00124"
     CDS             complement(15599..17302)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="CKV83_RS00610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00124"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_018373018.1"
                     /transl_table=11
                     /translation="MKDLQRLSLKKILTWLFFTLPTSYKLQVALLCTLELVLSVLSVVF
                     VVYFRNIIDAAVSKNSQFFWFSAMMLLMIVLTQLILQSLQRYQEEATKANIENYLKAYL
                     LTTLLQREFQAISQIHTGEWLSRLTSDTGIISRGVATIVPGLVGIFSKLFAVLLMVGYI
                     DSKFLWLIFLMGLLYIMIGLGLKLKLRYLYHNIQKKVSQLQVFYQDYLSSLLVINAFSL
                     QRKVTKQAQQYLDEHKKARLEQATFSNINITGLNAVLELAYLFVAVYCAYGIYIGTMSY
                     GTFIAITRLVTQVSYPFANATVYIPSFYSMLVSCERLMEVEELKVLKTELKTHSEITKF
                     YRKLDAIVFEQASFSYTDRKLLENIQFEIQKGDYIAFLGPSGCGKSTLTKLLLSIYELQ
                     KGELFLRLTNGEKVALDSSFHRLFAYVPQVKLLMVGTIRQVITFSDSLTAEEESRLWQA
                     LNLVCARELVEQLPQGLDFVLGEDGSGLSEGQLQRLSIARAIYSQSPILVLDESTSALD
                     EETEKAILENMKALTDKTIIIVTHRPAALEICNKQLHFSDSEIALHTKHS"
     gene            complement(17299..17757)
                     /locus_tag="CKV83_RS00615"
                     /old_locus_tag="SAMEA4412692_00125"
     CDS             complement(17299..17757)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CKV83_RS00615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMEA4412692_00125"
                     /product="S26 family signal peptidase"
                     /protein_id="WP_145955166.1"
                     /transl_table=11
                     /translation="MHNSLIRKELEAGRSIIYFTQGVSMRPLLYDKNHPKATQIYLEPL
                     THHQLAIGDIPIFQKQSNGQLVLHRLIASDDDYYYTRGDNCVSGEKVPREYVFGYVTKI
                     YRNGKWLSTDSKIYQAYVLVWLHSFWVRKPLMLLRQQLSKLKRKMIGK"
     gene            complement(18372..19451)
                     /locus_tag="CKV83_RS00620"
                     /old_locus_tag="SAMEA4412692_00126"
     CDS             complement(18372..19451)
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000040814.1"
                     /locus_tag="CKV83_RS00620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00126"
                     /product="Xaa-Pro peptidase family protein"
                     /protein_id="WP_026216884.1"
                     /transl_table=11
                     /translation="MEKIHQIVAHLDSENAGLAIFSDPVSINYLTGFYSDPHERHLFLF
                     VFRDREPLLFLPALETAGAKNKVPFEVIGYQDSENPWTKIADAIGQLSSNKVLAEFDSL
                     NLTRYHGLRQAISADFADLTPLINRMKLIKSADEVAKLMYAGSFADKAMQIGFQAISLE
                     KTETDIITEIEFGMKKAGVSKMSFETMVLSADNAANPHGHPGNNLIQNDALLLFDLGTE
                     NNGYMSDMTRTVAVGQPDQFKKDIYHLCLEAQLTAIDTIKPGVTAAEVDAAARNVIAKA
                     GYGEYFNHRLGHGIGSSVHEFPSIMEGNDLVLEPGMAFSVEPGIYIPGKVGVRIEDCGV
                     VTETGFDLFTQTPKELLYF"
     misc_feature    19494..19507
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.37"
                     /tool="antismash"
     gene            19624..20628
                     /gene="ccpA"
                     /locus_tag="CKV83_RS00625"
                     /old_locus_tag="SAMEA4412692_00127"
     CDS             19624..20628
                     /GO_function="GO:0001228 - DNA-binding transcription
                     activator activity, RNA polymerase II-specific [Evidence
                     IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="ccpA"
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636430.1"
                     /locus_tag="CKV83_RS00625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00127"
                     /product="catabolite control protein A"
                     /protein_id="WP_018373021.1"
                     /transl_table=11
                     /translation="MLNTDETVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEV
                     IERLDYRPNAVARGLASKKTTTVGVVIPNIANAYFSTLAQGIDDIAEMYKYNIIIANSD
                     ENDDKEVNVVNSLFAKQVDGIIFMGYHLTDKVRAEFSRSRKPIVLAGTVDLEHQLPSVN
                     IDYKQATADAVKLLAKNNKKIAFVSGPLLDEINGKVRLKGYKEGLKSSKISFNEGLVFE
                     AKYKYQEGYALAERVLKSGATAAVVAEDEIAVGLLNGVEDAGIKVPEDFEIITSNDSTL
                     TKFARPNLTSISQPIYDIGAIAMRMLTKIMLKEDLEDREVILNHTIAERKSTK"
     gene            20731..21726
                     /locus_tag="CKV83_RS00630"
                     /old_locus_tag="SAMEA4412692_00128"
     CDS             20731..21726
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373022.1"
                     /locus_tag="CKV83_RS00630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00128"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_018373022.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3.3e-11,
                     bitscore: 40.1, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILLYLEGEKLISKSGIGRAIKHQERALALAGIAYTTNPKEDYD
                     IVHINTYGFKSLHLLRRAKKQGKRVIVHAHSTKEDFENSFKGSNWLAPFVKNYLTFFYQ
                     QADHIITPTPYSESLLRSYGITRPISAISNGIELSKYQPNEAKEQAFRQYFNLSAEDKV
                     VVSAGLYFKRKGIVDFVKVAERMPHVRFIWFGQINKHLIPRDVVDIVEKNHPENVSFPG
                     YIKGPVFEGAMSGANAFFFPSYEETEGIVVLEALASYQHVLVRDIPVYRGWLDESAVVM
                     GSCNDDFVAALDAILAGQLDRREAGYGVAESRSIEAVSKQLAQVYHRVME"
     gene            21730..23061
                     /locus_tag="CKV83_RS00635"
                     /old_locus_tag="SAMEA4412692_00129"
     CDS             21730..23061
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373023.1"
                     /locus_tag="CKV83_RS00635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMEA4412692_00129"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_018373023.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1e-31, bitscore:
                     106.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGLFTDTYFPQVSGVATSIKTLKTELEKLGHTVFIFTTTDKHV
                     NRYEDWQVIRIPSVRFFAFKDRQIAYAGFTDAVKIAKRYHLDIIHTQTEFSLGILGKMI
                     ARELKIPVVHTYHTNYEDYVHYLAKGKIIRPSMVKYIVRSYCTQLDGVICPSEIVEDML
                     TDYKINAPKRVIPTGIDLEKFRRPELTDGDIRAIRDQLGILDDETFLLSLSRVSYEKNI
                     QAIIKAMPSVLSQGLQAKLVIAGDGPYLTDLKHLVSELGLEEVVQFTGMIAPGETALYY
                     KAADFFVSASTSETQGLTYLEALATGTPVIAHANPYLNQLITNRMFGTLYPYNQDLADA
                     IVDAIITTPDMTQEALEEKLYEISAENFGRTVAEFYLDTIMNHEARRANGEFAPIPVVI
                     ARKATKTGIVVARKSIYLPKRILMKSTVRSRRFIRDLSKRIEKD"
ORIGIN
        1 aggtcatgat gtgcaggatg tttctaaaga aggagctgat ttcgttgata cgactttggc
       61 tgttgttaag gaagtgactg ccaacgatgt caatcttggt attgtcattg atgcttatgg
      121 tgtaggtccc tttatgactg cgactaagat caaagggatg gttgcagcag aagtgtcaga
      181 tgaacgctca gcctatatga cacgtagtca caacaattcg cgcatgatca caatgggagc
      241 ggagattgta ggacctggtg tggcaagaaa tattgctaag ggttttgtag agggtgagta
      301 cgatggcggt cgccaccaaa tccgtgtgga tatgctcaat aaaatgtgct aaacaattaa
      361 aaaaaggaat tgaggacaaa ctcatgaaaa ttgctgttgg ttgtgaccat atcgtaacaa
      421 atgaaaaaat tgcagttgtt gattatctta aaacacaggg gtatgacgtc attgattgtg
      481 gaacttacga caatgttcgt acccactacc caatctttgg taaaaaagtt ggtgaagctg
      541 ttgcaagtgg ccaagcagat ttaggcgtat gtatctgcgg gactggtgtt ggcatcaaca
      601 atgctgttaa caaagtacct ggcattcgtt ctgctttggt tcgagacatg acgtcagccg
      661 tctatgctag agaagagttg aatgctaatg tcatcggctt cggaggtaaa atcacaggtg
      721 gtctcttgat gactgatatt atcgaagcct tcatccatac agaatacaaa ccaactgaag
      781 aaaacaaggc tttgattgac aaaattgcca aagttgaaag cctgaaccaa gaacaggctg
      841 atccacactt ctttgatgag tttttagaaa aatgggatcg cggagactat cacgactaag
      901 gggatataga catgattctg accattacaa tgaatccgtc tatggatatt gcttatcagt
      961 tggacggttt ctgcctagac actgtgaata gaccgcttga gacctacaag acagccggtg
     1021 gcaaagggtt gaatgtgacc cgtgtccttt cgcaactagg cgagtccgtt atagcaagtg
     1081 gcctcttggg cggtaaaatt ggcgagttta tccaagaaga attagataaa gttactattg
     1141 ctcatgattt ttacccaatt tcaggagata ctaggagttg tattgcaatg cttcatggtg
     1201 agcagcaaac tgaaatttta gaaaaagggc caacaattct caaaagcgaa gctcaaggct
     1261 tcttagagaa atttgaagaa cgggttcaaa cagtatctat tatttctatc tcaggtagtc
     1321 taccaaatgg cttgccagta aacttttatg aaaaaataat aaccatttgt caaaagtatg
     1381 acaagccaat tgtcctagat agttctggtg acagtttgaa atctgtcctg acaagtgaac
     1441 agaagccaac agtcatcaag ccaaatagag aagagctttc acagctgtta ggacgaaaca
     1501 tcacaggcga cattgctagt ctgaaaaagg ctcttcaaga ggaacttttt aatgggattg
     1561 agtgggtgat cgtatcgtta ggggccaacg gtgcctttgc taggcacatt gataggtttt
     1621 ataaggtttc tattcctaaa attgaagtgg ttaatcctgt tggttcagga gattccacag
     1681 tcgctggcat tacgtctgct ctggctcatg cagcatcaga cgaagatttg ttgaaaaaat
     1741 caaacgttct tggtatgctc aatgctcaag aaaaacaaac aggctacgtc aacatggaga
     1801 attacgcagc attatttgaa aaaatcaaag tagaagaggt ataatcatgg ttttaacaga
     1861 acaaaaacgt cggtatatgg aaaaactaag cgatgaaaat ggcatcattt cagcccttgc
     1921 ttttgaccag cgtggtgctt tgaagcgctt gatggcacaa caccaggatg atgagccgtc
     1981 agtagcacaa atggaggaat tgaaggtttt ggtggcagaa gagctgacac cgtttgcctc
     2041 ctcaatgctc ttagatccag agtatgggct tcccgcgact aaagcccttc ataaaggagc
     2101 aggtctgctc ttggcttacg agaaaacagg atatgatacg accagcacaa agcgcctacc
     2161 ggattgtttg gtagattggt ctgtcaagcg cctgaaagaa gagggggcag atgcgattaa
     2221 gtttttgctt tactatgacg ttgatagtga tgaagcaacg aatcgtcaaa aacaggccta
     2281 tattgagcgc atcgggtcag aatgtacagc agaagatatt cctttttatc ttgaaatttt
     2341 ggcttatgat gaaaagattg cggatgcttc aagtgcagac tatgctaagg tgaagccgcg
     2401 caaagtcatc gaagcgatga aagttttctc tgatgaacgt tttggtattg atgttctcaa
     2461 ggttgaagtg ccggtcaata tgaactttgt agagggcttt gcaaatggcg aaacagttta
     2521 cacgaaagaa gaagctgcct cttacttcaa acagcaaaac gacgccacac ctcttcctta
     2581 tatctacttg agtgctggtg tttctgccaa actctttcag gatacacttg tttttgcgaa
     2641 agcatctggt gcaaacttta acggggtatt gtgtggtcgc gcaacatggg ctggcagtgt
     2701 caaagcctat attgaaaaag gcgaggcagc tgctcgtgaa tggttgcgta caactggatt
     2761 ccaaaatatt gacgagttaa ataaggttct aaaagaaact gcaacccctt ggacagctcg
     2821 tgtttagaca ataaacaaca taaagtaaac aatttttgaa aaaattatta ttttttaaac
     2881 agaaagggtt tacatttata atcctttgtg ctataatgaa ctcatcaatc aaatatgggt
     2941 agatcgtaac tagataaata ggcgagacta caaatgaaca aaagggctaa tactctgggt
     3001 ttatttgtgg tctctttttg tacccaatag gatgaaacac catgggctaa aatgctaaat
     3061 ttggtagaac cgtagccgtc tggattttct tcgatttcat ctgtgaaaat cctcgtcgtc
     3121 ttggtcgggg tgcgtcgacg ccatttttcg tcgcatttct taacgggctt tgtatcttaa
     3181 taaactgaat tcggcctaaa atcctcgata aaattcaaaa acttcctcaa gtccagagac
     3241 ttgtcgtctg ttttctcatt tttcatcgga ttttttcacg gcctcatatc ttaataaaag
     3301 gaggatctgc atgtatcgtg ttttacaggc gctcaataat aatgttgccc ttgtaaagga
     3361 tgagcataac caacaatttg ttgtcatggg gttgggcatt acgtttcaaa aacgaaaagg
     3421 agatctcatc attgaggaaa aaattgaaaa agtcttttcg ctcaaaagta cagaatcaag
     3481 agagaacttc atgacgctct tgaaagatgt gccacttgat ttcattactg ttacttatga
     3541 tgttattgag acgctttctg acaagtatga ttatcctttt caggaatacc tctatgtgac
     3601 cttgacagac cacattcact gtgcctatag ggctgttttg gatgacaatt atcaggaaag
     3661 caagttgcct aatatttctc aggaatacag tattgaatat gttatggcaa aagaagcttt
     3721 agcaatgttt cggcaaaaga ttttagatga ttttcctgat gatgaaattg ggcgaattgc
     3781 ccttcatttt attaatgcaa aaggtgtgac agcagttgag aaaacaccaa aagttaagtt
     3841 gacacgatcg gtattaaaaa aagtacagga ggagttagaa cgcttaggta tcagacggac
     3901 tagggaaaat agtaatttct atgatcgtct catgattcac ttgacttatt ttctgcaata
     3961 cttagatcgt agtccaaatg agaatgctcc cttgatggat atggggaaac acattcaaat
     4021 cgcttaccca gaagcctatg acattggtag taaaatctat gagatgatcg cttcggaagc
     4081 aggagttgaa atttacgaaa gtgaaaaatt ttatattgtc cttcatatac aacgcctact
     4141 ctaatcacta aaaataaagg agaaaacaaa atgaatagag aagaaattac cctcttgggc
     4201 tttgagattg tatcatacgc tggtgaagca cgctcgaagt tgttggatgc tttaaaggct
     4261 gctcaaaatg gagaatttga aaaagctgaa gagctagtag aatcagcaaa ttcaagtatt
     4321 gttgaggcac atcatgcaca aacgagccta cttcaaaaag aagctgctgg tgaggattta
     4381 gcctttagcg tgacattgat gcacggtcaa gaccacttga tgacaacttt gctgttgaaa
     4441 gacatgatga aacacatgat tgaactttac aagagaggta ctaactaatg gataagttaa
     4501 ttgctcaaat tgaaaaagga aagccattct ttgaaaaact ttcccgtaat atctacttac
     4561 gcgctatccg tgatggattt atcgctggta tgccagtaat cctgttctca agtatattct
     4621 tacttattgc ctttgttccc aattcatggg ggttctactg gtcagatgac gttgttgcat
     4681 ttttaatgaa accttatggc tatacaatgg ggattctagc tttgctagta gcaggaacaa
     4741 ctgcgaaatc gttaacggac tcagtcaacc gtgatttgga gcaaacgaac caaatcaact
     4801 ttatgtcaac gatgctagca tcagtctgcg gtctactaat cttggctgct gatagtcttg
     4861 aaggtggctt tgcaaatggt ttccttggga caaaaggtct tttgtcagcc tttcttgcag
     4921 catttatcac ggttgcggtt tataaattct gtgtgaaaaa taatgtaacc attcgcatgc
     4981 ctgaagaagt gccaccaaat attgcccaag cttttaaaga tgtctttcca tttgcaggaa
     5041 caatcctttc actttatgct ctagatttat tagcccgcaa tactgttgga acaggtgttg
     5101 cagaagcaat tggtaaattc tttgaaccat tgtttagtgc agcagacagc tatgttggga
     5161 ttaccattat ctttggtgct ttcgcctttt tctggttcat aggaatccac ggcccgtcaa
     5221 tcgtagagcc agctattgta gcggtgactt atgctaatgc tgaactgaac ttgggcctct
     5281 tacaggcagg tcagcatgct gataagattt tgacttcagg tactcaaatg tttattgtaa
     5341 ccatgggtgg tactggcgct accttagttg ttccattcat gttcatgtgg ctgtgtcaat
     5401 caaaacgaaa tagagctatt ggacgtgcct cagtggttcc aactttcttt ggcgtcaacg
     5461 aaccaatctt gtttggtgcg ccacttgttt taaacccaat cttctttatc ccatttatca
     5521 tggcaccaat tgttaacgta tggttattta aattcttcgt tgacactttg ggaatgaact
     5581 catttacagc taacttgcca tggacaacgc cagcaccact tggtttggtc atggggacaa
     5641 acttccaagt attagcattt gtccttgctg ttactttgat tgtagtagat accttgattt
     5701 actatccatt cttaaaggtt tatgaccagc aaattcttgc agaagaacag acaggtcttg
     5761 cttcgaatga tgcgctcaaa gaaaaagttg ctgctaactt taatacgaaa aaagctgatg
     5821 ctatccttga aaaagcaggt gtagtcgaag cgaaagaaat cacggaacaa acgaacgttt
     5881 tggtgctctg tgctggcggt gggactagcg gcttattggc taatgctctt aataaagcgg
     5941 cgaaagaata tggtgcgcca gtgacagctg cagctggaag ctatggcgct caccgtgaaa
     6001 ttcttcctca ataccagttg gtcattctgg cccctcaagt agcctctaac tatgaagata
     6061 tgaaactgga aacagataaa cttggtattc aattagccaa aacagagggg gctcagtaca
     6121 ttggcttaac gcgtgatgga caaggtgctt tagactttgt taaacaacaa ctagcaaact
     6181 aaacattttg ttgaggacgg ttgaagcgat caatcatcct aacttagaag aggtgtcaac
     6241 atgacaaaaa cattgccaaa agattttatt tttggtggcg caacggccgc ttatcaagca
     6301 gaaggtgcta ccaaaacaga tggaaaaggc ccagttgctt gggacaaata tcttgaagat
     6361 aactattggt atacagcaga gccagctagt gatttttata atcgctatcc cgtagacttg
     6421 aaattagccg aagagtatgg tgttaacggt attcggatct ctattgcttg gtctcgtatc
     6481 tttccagttg gcaaaggcca agtcaatccc aaaggagtag catactatca caaactcttt
     6541 accgaatgtc acaggcgtgg tgttgagcct tttgttaccc tccatcactt tgatacacca
     6601 gaagccctgc attctaacgg agattttcta aaccgtgaga acatcgatca ttttgtggac
     6661 tacgcggctt actgttttga agagttccca gaagttaagt attggacaac gtttaatgaa
     6721 attggtccta ttggagatgg ccaatacttg gttggtaaat ttcctccagg gatacagtat
     6781 gacttggcca aagtcttcca gtcacatcat aacatgatgg tggcccatgc acgagccgtt
     6841 agactttata aagacaaagg atatactggc gaaattggtg tggttcacgc gcttccaact
     6901 aaatacccgt atgatcctga aaattctgat gatgttcgtg cagctgagct agaagatatt
     6961 atccataaca aattcatttt agatgcgact tatcttggac attactcaga taggacaatg
     7021 gaaggtgtca agcttatctt agaagctaac ggtggagaac tggatctccg agatgaagat
     7081 tttgaagttt tgaaagcggc caaagattta aatgactttt tggggataaa ttattatatg
     7141 agcgactgga tgcaatcctt tgatggtgaa actgaaatca ttcataacgg taaaggggaa
     7201 aaaggaagtt ctaaatatca gattaaaggt gtcggacgca gacaagctcc aaccaatatt
     7261 ccaaaaacag actgggattg gattatttat cctcaaggtc tttatgacca aatcatgcgc
     7321 gtcaaaaatg actatccaaa ctacaagaag atttacatca ctgaaaatgg acttggttac
     7381 aaggacgagt ttgttgacaa tactgttcat gacaatgcgc ggattgacta tgtcaagaag
     7441 caccttgacg tgatttcaga tgcgattaca gatggcgcta atgtcaaagg ttactttatc
     7501 tggtcactta tggatgtctt ctcttggtca aacggctatg aaaaacgcta cggtcttttc
     7561 tatgtcgatt ttgagacaca agagcgttat cctaagaaat ctgctcattg gtataagaaa
     7621 gtcgctgaaa cacaggtaat tgaatgagct tgaagctcag agtttagagt cccaataaaa
     7681 taataaaaga atagcaagtg ctgattgttc cattactgga gaagatgagc cttgctattt
     7741 ttgattggct gaacataccg agacatcaat agtagctgac gaagtatgct tttgattttc
     7801 aaagagtact ggtgtttctg tgaaattttt gataggacag cctgactgtt tttgtatata
     7861 atagaactag tgaagaaagc gtttactgat taagcggtaa aacaggagga agaccgatgt
     7921 ctaaagaaaa gtatattatg gccattgacc aggggacaac tagttcgcga gcgattattt
     7981 tcaataagaa cggtgaaaac gtcgcttcta gtcaaaagga atttcctcaa ctctttccgc
     8041 aagctggttg ggtggagcat gatgctaatc agatttggaa ctcggttcaa tccgtcattg
     8101 caggggcttt tatcgaaagt ggtatcaaac ccagccagat tgaagcgatt gggattacca
     8161 atcagcgtga gacgactgtt gtctgggaca agaaaacggg tattccaatc tacaatgcta
     8221 tcgtttggca atcgcggcag acagctcctt tggctgagaa gttgaaaaaa gagggatatg
     8281 tggatttttt ccacaaaaag acgggtttgg tcattgatgc ttatttctca gcgaccaagg
     8341 tccgctggat tttggaccat gtatctggcg cgcaggagcg tgctgaaaaa ggggaattac
     8401 tctttggcac gattgatacg tggttggttt ggaaattgac agacggtcgt gcgcatgtga
     8461 cagattatac caatgcagca cgaaccatgc tctacaacat caaggaactg aagtgggacg
     8521 atgacatcct agacttgctc aatattccaa aagccatgtt accagaagtg aaatcgaact
     8581 cagaagtgta tgggtatacg aggccttatc acttctacgg tggtcaggta ccaatctctg
     8641 gtatggcagg cgatcagcag gcggctctct ttgggcagct ggccttagag ccaggcatgg
     8701 tcaaaaatac ttacggaaca ggttccttta tcatcatgaa tacgggagaa gatatgcagc
     8761 tgtctgaaaa caatctcctg acaacaattg gctacggagt gaatggtaag gttttctatg
     8821 ctcttgaagg gtcaatcttt atcgcaggga gcgctattca gtggttgcgt gatggtcttc
     8881 gtatgattga aacgtcacca gagtcagaag gtttggcagc tgcttctggc aatgatgatg
     8941 aagtttacgt ggtaccagcc tttacagggc tcggtgcgcc ttattggaat tccaatgctc
     9001 gcggttcggt ctttggcttg accagaggaa ccagcaagga agactttgta aaagcaacgc
     9061 ttcaatcgat tgcctatcaa gtccgtgatg ttattgacac catgaagatt gactcaggta
     9121 ttgctatccc acagcttcgt gtggacggcg gtgcagccat gaacgatttc ctcatgcaat
     9181 ttcaggcgga tatcttgggg attgacattg ctcgtgctaa aaatctggaa acaacagcac
     9241 ttggtgcagc cttcttagca ggtctttcag ttggttattg gaaagattta gatgcgataa
     9301 aagaactcaa tgaaactggt cagcttttcg agccaagcat ggatgaatcc cgtaaggaac
     9361 agctttacaa gggctggaag aaagcagtca aagcaactca agtctttgca gacattgatg
     9421 aagaagatta gaagctgctg ctttctaaac gcaggctata atcaggaaag cacagggaaa
     9481 atactacctg tgaaaaagca aaaacgactg ataacaattc tttgagacat aaagattgtc
     9541 tatcaatcgt ctttttgcag ttaatttcta gttttttaaa cattattttt attagattgc
     9601 agtgaattca gaacagacag cctcttcttg ctgtgcctat aatttaaaaa ccagccaatt
     9661 tagctggttt tagtattatt gctggttaat accaggtttt ggaggtgttt caacacctcc
     9721 agaagttgta atcacatctt ctttttcaaa agtgacagtc ttaaactcgg gtttttgata
     9781 gtcttttgtc ataaaaaact ccttttacta atttaattta cctagagtct atcatataat
     9841 aaatgggttg tcaagaacta ctgcaaaaaa acagattaaa tacagaaggg gtctgcattt
     9901 tttagcaggt tcaacctatg agagcatctt gatgctcctt gaatttacct ctgtttttgt
     9961 gtataatagg agaacaggtt cattgaaagt gaggagaaaa atgtacataa tcacctgtac
    10021 aaaagctagc ctgcgctatc gttgggaaag cgaggtgctt ctaacgaatc ttcaaaagca
    10081 cgggtcatat gacattatct tcctgctgta tggagaggat cgttccatgg gcccttactt
    10141 acaagaaaag tacggaatca gttattacca ttttgaagat aatcgctctc aaaaacagta
    10201 tccaacctct attcgcccct atctctggta tcaattttta agccaacatc cccagatgga
    10261 aaaggaagtt ttcttttaca tagacacaga tatcattttt cgagaaatga ttgcttttga
    10321 caagatccct gttgatgctc aaaattggta tggagctgat agttattgcg tgaaagcaag
    10381 ttatttgcga gctaagcatc ccctttattt acaggggctg caaactattt tatctgtgac
    10441 agatgaggaa ttgaagtgga cagaagatag cccagccggt gcacagtggc ttattgctca
    10501 gccaacagca gcttttttta atgaaatgta tgtgcattgc gaacgcgtct atgactttct
    10561 agtcaccatg gaacggattc cacatttaca aaaagaggag cgattagaag agtatggaaa
    10621 atggttgaca gacatgtggt gcatggcatg gttggcacct aaatacggca ttactgttca
    10681 tatatcatct gaattggatt tttcatggcc aacttattcc gctgagcatt gggagcgcta
    10741 taagatactc cataatgcag gagtcactag tgaaaatgca gatgcttttt acaaggccaa
    10801 atggacacat attcctcctt tcttttttaa tcatgataac gtctcttcta aacttggttc
    10861 catttattac gtaaaggcgg tacaagctgt gactatcaga ccacaagact acgataaggt
    10921 taaaatccta ggaactttta ttactaatca ggtgaaagac acctatattg cgattccttt
    10981 ggatgaggca aagcaaaaag tttctggcta cattgaactc aacgacagta gctatttgct
    11041 ttggacattg attcaagaaa agggttctat acaagaaatt attgaagctt atagtcaaac
    11101 ctttgagatt gagaaagacc aagccaagca agatttattt gattttatcg catatttgga
    11161 tacgatgaag attattcagt ttgagtgtgg agttagcact gattaagtta gaaaatttcc
    11221 cttgttttag aatggcgtag gcagtgattg aatgactgtt ttgcccactt ctacagaacc
    11281 taacatttct atttttgctg gtcaaaaaaa cgttggtatc agcatttcgg attttcacaa
    11341 ataggttttt agaggtgtcc ttttcaaaaa tgcctaaagt taataagttt taacgggaga
    11401 cgttaaaggg ctcaaaatca ttatttagcg ttttcctcac taatgaaagg atgttgtatt
    11461 tgacagcaca gtcgtttatt gcgattatca ctgcaagaag tggttcaaag gcgctaccta
    11521 ataaaaatat tcaaaaagta ggaaatcgga cgctgattga aatcactgcg gaagaagctc
    11581 ttgcttctgg tattttttct gagattgtct tttcaacgga ttccgaggag tatgcagaaa
    11641 tcctacgtcc ttacggtgtt acaattgact tacgtcccca gtatcttgct gaggatacca
    11701 cgccacattt ggatacacta cgctatgtct tacggcgtta tccagatcat caggattata
    11761 tgcttttaca accgacttct ccattcagac gggcagaaca tatgattgaa gcatataaac
    11821 tatatcagac gggacaattt gacagtgtgg tcagttttac tcaggttgat aagccaacac
    11881 gcctaatcac acgcttagtt gatgataagc ctgttgatat ttatggtaat gacaaggctt
    11941 acacgcgcca aggtcaagaa aaagagtaca ccacaaacgg tgctatctat atctcatcaa
    12001 agggaaacta tctgaaaaaa ggctcctatt tggatgaaca ttgcggtgtc tatctgatga
    12061 ataagcgtga ctctctcgat attgacgatg agatagatct gctgctagca aatgttttaa
    12121 acaaccagta aacccagaca actattgcgt cgaataggtc aaactagaaa agaaacgaga
    12181 cggagtattt tatacgtaat ctttaacgat tatacgcttt tgtgatgagg ggaagccgtc
    12241 atggtggtct gtttcagccg cattagattt gatttcatac gttaagaagc caaaattttt
    12301 agacatagat accctaaaag gatcaggagg aaacagtgga gcgatttcgt attggtttgg
    12361 caggtctggt gatccagata acttgccgtt ttgattcaac acggatattt tgcaaagatt
    12421 acctaacgga tgctgaacct gattttgaaa tcaatgttga gcagaaagac attgactttg
    12481 agcgagcaag aggcggtgaa aaagctcggc atttttcagg aaactattta gaacaaattg
    12541 ccttatatcg attgatctgc gaagtattgc cagcttatga tcgactactc attcatgggt
    12601 cggcaatcgt attagatgat caagcctatt tatttacagc accaagtgga acagggaaat
    12661 caactcacag ccagctatgg ctgaaagtct ttggtgatag agcccgtatc ttaaacgatg
    12721 ataagccctt gttacatatc acaggtgagc aaattttgat ctatggaacg ccttgggatg
    12781 ggaaacatag taggtcttac aatggttctg cgccattaga agccatctgt tttttaaacc
    12841 aaggcttaga aaacgcggct atccggttat ctgaaacagt tgcttttgat gctttggtaa
    12901 cgcaaactta cagacccctg caatcaattg accaactgaa aaaaacatta gctttgctgc
    12961 aaaaagtaag ccatctaccg acttaccaat taacctgtac gatctctaca gaagcggtag
    13021 atgttattta cgagaaaatg acacataaaa atcattccaa caaaataaac aacaacgagg
    13081 agaaataaaa tgaagttaaa agaagggatc ttgcgccatc acgatcgtaa cgatgagtat
    13141 attggcgtta caacaggaga tttggcagaa acgttcaatg gcatgattcg ctacaatacg
    13201 acaacccatt tcattttaga aaaacttcag gctgatacta caaaagaaga attaattact
    13261 agcctttgtc aagaatatga tgtcactcct acagaagcca gtgctgactt gacgccatta
    13321 cttcaagaat tgacgacgct gggtttatta gagaaataaa ctaaatatag agtaaaacac
    13381 tgaaaatagg gaagcggccc ttgttttcag tgtttttaga ttacgtgact ttaagccgtt
    13441 ttattggtta ggcaatattt tctcaaaagt gggaagggta actaattgtt tttcaacttc
    13501 ctgacttttt agtgagcttt taattgttta cgggcggttt tggctgttgg taagctgctc
    13561 tgtataaatc acacgttttt ctttaacctt tgtgattcct tcaatagaag aagacattaa
    13621 ggttgcagcc acatcaaacg aagttgaaag ccgtaaatca atcatttcca tcggtgtata
    13681 tctcggtaaa atcgttacct ccggaattcc atgatagtca agatcgtctc ttggatgcgg
    13741 cttgaggtag acatgataac ctgcctcttt tgcttcttgg gccatcttaa agtagaagta
    13801 gtactgcttt gcataatccg gacttttatc ttcttttttg aaagtagacc aaaaatcgtc
    13861 agctaaaggc tgagttaaaa tcagataaga cggtgaaata agattaatat cttctacttg
    13921 ataaagcgca aataactttt tcagatgggt ttcttcctga cgctcaaaca attctctacg
    13981 agggacttca ataaatttgt ccaaaaaacg ggcgtagaag ctgttatctt taatcttact
    14041 aatgtcatta acttcaatat ccaaacaagc cgggttgaat ccgtaatgtt ctagagaaga
    14101 atcaacatct gataagccag cgagttgggc ataatgatag tgaaaattta aaccgtcttc
    14161 tattagatgg taagggtatt ttctatcccg aaattcctga ccaacctgat cagcatcatt
    14221 aaaaagataa acatgatcct cttcttcaag ccaatcaaaa tactgcttgg tctgaatgat
    14281 tttgcctgtt agaatttcaa cccaaatatc agggaaaaat gcttttatac gctccgctaa
    14341 ttcttgatgt ccacgaacat taaaatggag aaagagcgct atggattctc ctttttgttt
    14401 tttcatcaag gaaatcataa cttgcatatt ggtaaaacaa atatattttt tcatcgtggc
    14461 tcctctttat ttaagcgcta tttttctttt ttccggctta gtaaacatac tgctaatgaa
    14521 aaatttcgcc atcttttgga tgttggaatc aagcgataaa gataaaagag aggcaaaaga
    14581 taacgatgct tttgcaaggt aggaaaacgc aactgcatcg tctttaccgg aggaaagaag
    14641 cgctctttcc agtagagcca ttgattgcca ttagaatagt ttacctcatt gataatctgg
    14701 ttttccatca aaccataggt accggatgac aacatgtagg aaaggacgtt tctgtcatca
    14761 tctgtcaagt cagtcaaaga gacggcgtgt gccccaaata atttaaaagc caattttcgt
    14821 tgttgctgtt caaagtcagt caggttgagt ttaaacaact ctttcttgat ataactccaa
    14881 tctaagttgt cgtactcagt ttctaaaaat aagaaaagat caaccaagct acggatacca
    14941 gtccctgatt gcgaataatg tttgtaatca tgaagcattt gatagagata aaaatcttcc
    15001 aagctgaaat ggtaagcaaa gggcctatct tgatctggca ggagacgaga tttgacatca
    15061 tcataataat cactatctat tctactcagc ggatctatta actttcgatg catttcgaaa
    15121 tgaaaaatag gctttttcat ataagcatca acattaattt cataggtaaa gctatatccc
    15181 tcttctgtga aaaaatgctt aacttctttt tgaaaggatt catcaaagag aatatcatta
    15241 tcggacatct cacgcatccc tagtttggga taataggttt ttaaaagaat gccctttaat
    15301 tccatatacc aaattcctga acggcttagc cattgggtta ttttttgacg ttcatgatca
    15361 aacagtaatt ctcttcgaat accttgattt ttagcttctt gaagctcctt tggtagttca
    15421 atatagtctt ctagaatcat tgctaccata gcagatagac tatgaaattg agcaaactga
    15481 gcaagatttt ctaagttcat ctttgctatg atgtcatgat taatcggctt tctttgaagg
    15541 taatacctta ataaatagat gatatcttcg tgtgtttttg aaaacatatt ctttcttcct
    15601 aactgtgttt ggtatgcagt gctatttcag agtctgaaaa atgcagttgt ttgttacata
    15661 tttctagggc agctggtcta tgggttacaa taatgatcgt tttatctgtc agagctttca
    15721 tattttctaa aatagctttt tcagtctctt cgtctaaagc actggttgat tcatctagta
    15781 ccaaaattgg cgattgagaa tagatagcac gtgctattga caaacgctgc aattgacctt
    15841 ctgataaacc tgaaccatcc tcccctaaga caaaatccaa tccttgagga agttgctcaa
    15901 ccagttcacg tgcacaaacc aaattaagtg cctgccaaag acggctttct tcttctgcag
    15961 tcaaactgtc agaaaaggta atcacttgac gaattgttcc aaccatgagg agcttcactt
    16021 gggggacata ggcaaataaa cgatgaaagc tcgaatctaa ggctactttt tccccatttg
    16081 tcaggcgtaa gaaaagttct cccttttgaa gctcatagat ggagagaagc aatttagtca
    16141 gagtactttt cccacagccg gatggaccta agaaagcaat ataatctcct ttttgaatct
    16201 caaattgaat attttccaag agttttcgat ctgtataaga aaaacttgct tgttcaaaaa
    16261 caatagcatc aagctttcta taaaattttg taatttcgga atgtgtcttc aactctgttt
    16321 tcagaacttt aagctcttct acttccatta agcgttcgca actaactaac atggaataaa
    16381 aactcggaat atagacagtt gcatttgcaa atgggtaact aacttgggta accaagcgag
    16441 taatcgctat aaaagtccca taagacatcg ttccgatata aatgccgtag gcacagtaaa
    16501 ccgctacgaa taggtaggct aactctagaa cagcattgag acctgtaatg ttgatgttgg
    16561 agaatgtagc ctgttctaat ctggcttttt tgtgttcatc caaatactgt tgagcctgtt
    16621 tagtcacttt tctctgaaga gagaaggcat taatcactaa gagactgctc aaataatcct
    16681 gatagaagac ttgcagttga ctaacttttt tttggatatt atggtataga taacgcagct
    16741 ttaattttaa tcccagacca atcataatat aaagcagtcc catcagaaaa atgagccata
    16801 aaaatttgct atcaatatag cccaccatca gtagaaccgc aaagagtttg ctaaagatac
    16861 caactaaacc tgggacgatt gtagccacgc ctcgtgaaat gataccagta tctgatgtaa
    16921 ggcggctaag ccattcgcca gtgtggattt gagaaatggc ttggaactcc ctttgaagca
    16981 gagtcgtcaa taagtaagcc ttaagatagt tttcaatatt agctttagtt gcttcttcct
    17041 gataacgttg tagcgattga aggatgagtt gagtaagtac aatcatcagg agcatcatgg
    17101 ctgaaaacca aaaaaactga ctattttttg aaacagccgc atcaatgata ttgcgaaagt
    17161 aaaccacaaa tacgactgat aaaacggata gaaccaattc taaagtacag agtaaagcaa
    17221 cctgtaattt gtaagacgta ggtaaagtga aaaataacca tgtcaagatt tttttaagag
    17281 acaagcgttg taaatctttc atttccctat catctttctt ttaagtttag agagttgctg
    17341 gcgaagaagc attaatggtt tacgaaccca gaagctgtgt aaccagacca gaacataagc
    17401 ttggtaaatc ttgctatctg ttgacaacca tttcccattt cgataaattt ttgttacata
    17461 gccaaacacg tattctcgtg gtactttttc accagacaca cagttgtccc cgcgcgtgta
    17521 gtaataatca tcatctgaag caatgagacg atgcagaact agctgaccat tggattgttt
    17581 ttggaaaata ggaatatcac cgatggctag ctgatgatgc gtcagcggtt ctaaataaat
    17641 ttgggtggct ttcggatggt tcttgtcgta caagagcgga cgcatactaa ctccttgggt
    17701 aaaataaatg atcgatcgtc ccgcttctaa ttcttttcga ataagtgagt tatgcacaat
    17761 tctgtcctcg ctgatgtgat tgttgatatt aaaaatagtt ttttgggggg cctgcaatgc
    17821 ctgcttctag gttaaatttt tacaaactgt tcaagaatat cttgataccc gactaactga
    17881 gccccttgtg gtgatatttg acttgaaaga atgatataga ggggctatta tagaaagata
    17941 aggcaagcaa ctctatcaat cgctaactta cttgcaactt aaaaagaata ctcattcctg
    18001 attccatcat ctggtacgtt gtattttgat gcacttataa cgataccgct tctctatacc
    18061 tttgtcaaga gacaatagta aaatattaga acctgtagtc acagttcaac actttgattc
    18121 aaggataaat ttccacactc gtcgttcgtt ttttcaaaat atagtttgta ttttgaaaaa
    18181 cttgccttga tgatcgaaaa atgatttcct gaattaaaga atcttactga tgtctacagg
    18241 ttcttagact tgtttggaga cgataagtct cttgaatcgg tggagaaagc atttcactga
    18301 cgttagtgaa atcacggctt ttgtctcact ccccagtcaa atattcccaa attagatttg
    18361 gtgaggtgct cttaaaaata taataattct ttaggtgtct gggtgaagag gtcaaaacct
    18421 gtctcggtta caacaccgca gtcttcaata cggacaccga ccttgcctgg gatatagatc
    18481 cctggttcaa cggagaaggc catccctggc tcaagaacca aatcattacc ctccataatg
    18541 gatgggaatt cgtggacgct gctcccaatt ccatgtccca gacgatgatt gaaatactca
    18601 ccgtagccag ctttagcaat gacgtttcgg gcagcggcgt caacttctgc tgcagtcaca
    18661 ccaggtttga tggtatcaat agctgtcagc tgcgcttcca agcagagatg gtagatgtct
    18721 tttttgaact ggtctggctg accaacagct acggttcgtg tcatatcaga catgtagcca
    18781 ttgttttccg ttccaagatc aaagagcaaa agggcatcat tttggatcag gttattgccg
    18841 ggatgaccgt gcggatttgc agcattgtcg gctgatagaa ccatggtctc aaagctcatc
    18901 ttggacacac cagctttttt catgccaaat tcaatctcgg tgatgatgtc tgtctccgtt
    18961 ttttccaatg aaatcgcctg aaatccgatt tgcatagcct tgtcagcaaa gcttcctgca
    19021 tacataagtt tggccacctc atcagctgat ttgatcaatt tcatacggtt gattaacggg
    19081 gttaggtctg caaagtcggc cgagatagcc tgacggagac cgtggtatct agtcagattg
    19141 agactgtcaa actctgccaa gactttattt gaggagagct gaccaatagc gtctgcaatc
    19201 ttagtccacg gattttctga gtcttgatag ccgatgacct caaaagggac cttgtttttt
    19261 gcgccagcgg tttccagagc tggtaggaaa agtagcggtt cgcggtctct aaagacgaag
    19321 aggaagagat gacgttcgtg cggatcgctg taaaatccag tcaggtaatt gatggagaca
    19381 ggatctgaaa aaatagctag accagcattt tcactgtcca agtgggcgac gatttgatgt
    19441 attttttcca taaaatagac caactttcta atcttagaaa ttaagttatt cccatttttc
    19501 caaaaaatct ctgaaaaagc aaggaaaaag agcgttttca cttgaaagac attctataaa
    19561 atgttaaact aaaggataga atgtaagcga aattttcaaa aacgatagaa aggacattca
    19621 tttatgttaa atactgacga aacagtcacc atttatgacg ttgctcgtga agcaggagtt
    19681 tctatggcaa cggttagccg tgtcgttaac ggcaacaaaa acgttaagga aaatacccgt
    19741 aagaaagtcc tcgaagttat cgagcgcttg gactaccgtc ccaatgccgt tgcgcgtgga
    19801 ctggcaagta agaaaacaac gacagttggg gtcgtgattc caaatatcgc taatgcctat
    19861 ttctcaactt tagcgcaagg gatcgacgat atcgccgaaa tgtataagta caacatcatc
    19921 attgcgaaca gtgatgaaaa cgatgataag gaagtgaacg tagtcaattc tctttttgca
    19981 aaacaggttg atgggattat cttcatgggc taccatttga cagataaggt acgtgctgaa
    20041 ttttcgcgct cccgcaagcc gatcgttctt gcaggaacgg ttgatttgga acatcaattg
    20101 ccaagtgtta atattgacta caagcaagcc acagctgacg ctgttaagct cttggcgaaa
    20161 aacaataaga aaattgcctt tgtatctggc cctcttctgg atgagattaa tggtaaggtg
    20221 cgcttaaagg gttataaaga agggctaaaa tctagcaaga tttcctttaa cgaggggctt
    20281 gtctttgaag ctaagtataa gtatcaagaa ggttatgcac tggcggagcg tgtgcttaag
    20341 tcaggtgcca cagcagcagt ggtggcagag gatgaaattg ctgtcggtct tttgaatggt
    20401 gttgaggatg cggggattaa ggttcctgaa gactttgaaa tcatcaccag caacgattca
    20461 acgctcacta agtttgcgcg tccaaacttg acctctatta gccaaccaat ctacgatatt
    20521 ggtgccattg ctatgcggat gttgactaag atcatgctca aagaagacct agaagaccgc
    20581 gaagtgatcc ttaaccacac gattgcagag cgcaagtcaa ctaaataaac aataaaatcc
    20641 agctcagttg tgagttggat ttttaaggtc catagccatt gtaatcacct gtccattgtc
    20701 tttttgtctt gaaaaagcta taataaaacc atgaagattt tgttgtattt agagggagaa
    20761 aagttaatct ctaagtcagg gattggccgc gctatcaaac atcaggagcg ggctctggct
    20821 ttggctggga ttgcttatac gactaaccct aaggaagact atgacattgt ccacatcaat
    20881 acctatggat ttaagagttt acaccttttg cgccgtgcta aaaagcaggg gaagcgtgtg
    20941 attgtacacg cccattcgac taaagaagat tttgaaaact cctttaaagg ctcgaactgg
    21001 ttggctcctt ttgttaaaaa ttatctgact ttcttttatc agcaggcgga tcatattatc
    21061 acgccgaccc cttattcaga gagtcttttg cgcagctatg ggattactcg cccgatttcg
    21121 gctatttcaa atggcattga actcagtaaa tatcagccaa acgaggccaa agagcaagcc
    21181 tttcgccagt attttaattt gagtgctgag gataaggttg tcgttagtgc agggctttat
    21241 tttaagcgca aggggatagt ggattttgtc aaggtggccg agcgaatgcc tcatgtgcgc
    21301 tttatttggt ttggtcagat taataaacac ttgattccgc gggatgttgt cgatattgtg
    21361 gagaaaaatc atcctgaaaa tgttagtttt cctggctata tcaaaggccc tgtttttgag
    21421 ggtgctatga gtggtgcgaa tgctttcttt ttcccgtctt atgaggagac tgaagggatt
    21481 gtggtgctag aagctttggc tagttaccag catgtgctgg ttcgagacat tcctgtttat
    21541 cggggctggc tggatgagtc ggctgttgtg atgggaagct gcaatgacga ttttgttgcc
    21601 gcacttgatg ctattctagc tggccagttg gaccgccgag aggcgggata cggtgtggct
    21661 gagagtcgct ccattgaagc agtttccaaa caattagctc aggtttacca tcgcgttatg
    21721 gagtaagata tgcgtattgg actttttaca gatacttatt ttcctcaggt ttcaggtgtt
    21781 gcgacatcaa tcaagaccct gaaaacagag ctggaaaagt taggtcatac ggtctttatt
    21841 ttcacaacta cagataagca tgtcaatcgt tacgaggatt ggcaggtgat tcgtattcct
    21901 agtgtgcggt tttttgcctt taaagaccgt caaatcgcct atgctggatt tacggatgcg
    21961 gtcaagattg caaagcgtta tcatctagac attattcata ctcagacgga gttcagtctg
    22021 gggattttag ggaaaatgat tgcccgggaa ttgaaaattc cagtggttca tacctaccat
    22081 accaactatg aggattatgt ccactatttg gctaagggaa aaattattcg accgagcatg
    22141 gtcaagtaca tcgtgcgttc ttactgtact cagctagatg gggtaatctg tccgagtgag
    22201 attgtcgaag acatgctgac agattacaag attaatgcac caaagcgtgt catcccaaca
    22261 ggtattgacc tagagaagtt tcgcaggcca gaattgacgg acggggacat tcgagctatt
    22321 cgcgatcaac tgggcattct tgatgatgag acctttttac tcagtctatc gcgtgtctct
    22381 tatgagaaga atattcaggc tattatcaag gccatgccgt ctgtattgag tcaaggtttg
    22441 caagctaaat tggtcattgc aggcgatgga ccctacctga ctgacttaaa gcacttggta
    22501 agtgaattag ggcttgagga ggtcgttcag ttcacaggca tgattgcgcc aggagagact
    22561 gcactctact acaaggcagc agactttttc gtatcagctt ctacgtctga aactcaggga
    22621 ttaacctatc ttgaagcgct tgctacaggg acgccagtga ttgctcatgc caacccttac
    22681 ctcaatcagc tcattacgaa tcggatgttc ggcacgcttt acccttacaa tcaagatttg
    22741 gccgatgcta tcgtggatgc tatcatcaca actccagata tgactcaaga agctttggag
    22801 gaaaagctct acgaaatttc agcagaaaat tttgggcgta ctgttgcgga attttatctg
    22861 gataccatta tgaaccacga agcccgtagg gctaatggcg agtttgctcc tattcctgtt
    22921 gtcattgcca gaaaagcaac caagacaggt attgtcgttg ctagaaagag catttaccta
    22981 cccaaacgga tcttgatgaa atccacagtt cgctccagac ggtttattcg tgatttgagc
    23041 aaacggattg agaaagacta ggagacttgc catgaagaag tacggatctt atcttactgg
    23101 actgaggaga tttatcggct tttggcttat ctaggagtga ttgtttatga tgagatgaca
    23161 gcgaaagctt ggatggtctc tagccttgtt tttcacaacc cgttttgatt gcttttttct
    23221 ctctgctgtt cgggttaagg cgaggatttg cttggacttt cccaattcta gtcagtttgt
    23281 tatttgtgcc atctgtgatt tacacatatg tcgcttatcc tgctgaggga atggaagctt
    23341 acctgttgcc ttatggcct
//
