LOCUS       NZ_FWXV01000011        11812 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Kibdelosporangium aridum strain DSM 43828, whole genome shotgun
            sequence.
ACCESSION   NZ_FWXV01000011
VERSION     NZ_FWXV01000011.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kibdelosporangium aridum
  ORGANISM  Kibdelosporangium aridum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Kibdelosporangium.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900176515.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:02:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,283
            CDSs (total)                      :: 11,193
            Genes (coding)                    :: 11,032
            CDSs (with protein)               :: 11,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 3, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 38 of 161
            Pseudo Genes (incomplete)         :: 135 of 161
            Pseudo Genes (internal stop)      :: 6 of 161
            Pseudo Genes (multiple problems)  :: 17 of 161
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:58:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 19577
            Orig. end                         :: 31389
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FWXV01000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11812
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11812
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11812
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6812](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6812
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    104..117
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.71"
                     /tool="antismash"
     gene            266..1399
                     /locus_tag="B9C43_RS42995"
                     /old_locus_tag="SAMN05661093_08772"
     CDS             266..1399
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018330563.1"
                     /locus_tag="B9C43_RS42995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08772"
                     /product="MFS transporter"
                     /protein_id="WP_084433168.1"
                     /transl_table=11
                     /translation="MQTGTGVRWALVCAGTALIGTCYGFARFAYGLFAPEFQTQFQISS
                     TVSGIIGSGSYIGYCVAIVASLVLTERLGARRIAVSAGVVATFGIAMITFAPSAPVLAA
                     GVLIAGSSTGLASPPMAAAVSRWIHAPAQDRAQSIVNAGTGLGVLVSGPIALALIDEWR
                     WAWAVFTVISAAVTVWLSKAIPFTESEGHTDTAGNGWRPGTFLLIAGAFLMGFSSVAMW
                     TFGRDLVTSVGHVSDVVSTSMWAVLGAAGFVGALSGDLVARAGMARSWTTVMVAMAGAT
                     LLLAFLPGTPVPIFIAAAVFGASYVSLCGVILLWSTRIYPQRPSFGVGVSFLMIAVGQV
                     AGAPLAGVLTDVSGGTAAFYACAAIGLIGACIRPRPS"
     gene            complement(1365..1997)
                     /locus_tag="B9C43_RS43000"
                     /old_locus_tag="SAMN05661093_08773"
     CDS             complement(1365..1997)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025687.5"
                     /locus_tag="B9C43_RS43000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08773"
                     /product="DUF4386 domain-containing protein"
                     /protein_id="WP_084433169.1"
                     /transl_table=11
                     /translation="MTIRKTSARVVGALFVMATAAGVVSAVLLGPGDQASAPASAAALM
                     VLIMAVAIAMIPPVLFPILKEHNEALALGYVVARTLEVVLVLPATVGPLMSLSGAPDDI
                     VRIVTGTYDVWGHPGSMVFFCLGAAILNVLLFRSGLVPRWISGWALIGVLPYLADAGLV
                     MFGALAPFSAIHSVLVIPLALNEMVLAGWLLTRGFAVTTAGAGYKRR"
     gene            1996..4803
                     /locus_tag="B9C43_RS43005"
                     /old_locus_tag="SAMN05661093_08774"
     CDS             1996..4803
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.5"
                     /locus_tag="B9C43_RS43005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08774"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_084433170.1"
                     /transl_table=11
                     /translation="MGLTVDDTGVLPVWAGFAEGVRCDRLGGRSTSGSSAVVRIGLLGG
                     VRVTSDDGEPVDIGSAKSQAVLAALALSPGTSVTVSRLVELVWADEPPQTAHKALQWHI
                     AQLRKGLGSEAIVRVGAAYRLDVAADAVDVARFQRHFRDGDFSAALAEWGGTPLAGLDA
                     PGLAAAVAGLTEQWLNAVEADLERRVGNDPRGVIGSLAELAERYPLRENVWALLMTALY
                     RVDRQADALAAFRQARHHLVTELGVEPGPALRELESRILDQDTRLRERAAHEGYVPRRV
                     GPLFGRDEDLQAIADALARSAVVTLVGPGGIGKTQLALAAAADHGQLIELAEITSPADV
                     PRAVADALGVAQRQGRTLTQSIVAAFRSRSALLVVDNCEHVIDGAAELIRAVVSGCPQV
                     HVLATSRERLSLAAEQVLAVGPLDLHAGAELFNARATAADRTYDAAAHRDHVTEICRQL
                     DGIPLAIELAAARTISHQPADLVARLNDRLRATGSRRTGAARHRTLRAAIQWSYDLLTP
                     AEQTLFQQLSVFSAPFDLSAAEAVADGADGLISALVERSVITVDNGPFGRRFRLLEPMR
                     QFAAEHLRDRDVIAERHARWCVSEVTHIHRLLTGPDEIEGVARLAELWPNLRAAVTWTR
                     DVGLADALVRPIVTELPLRGRQEIGVWAEHILAMTSDADVRAFWLVWVAERYTQNANPA
                     GYREVAEHYGTDRPLSRYADAYACGDGEALWQCLPDAVAGLHSDDLAAFLEMTSAGILL
                     GTGRFEQVDKSVTVLADRYRVHGPPTLLHWALQTLGYRASFQGRAEDADRYFDEASRVS
                     LPAGTLSANKSTEARSAFRRGERQRAFQLLRSHIDELIDTDNVVAASIVCIEFVTMMAK
                     IDRITEAAHMLRYLKAVNEFGALAARTLVAEAATRIAEHSADTTPAVDDRAALAYMRDV
                     LVELE"
     gene            4850..4993
                     /locus_tag="B9C43_RS57100"
                     /old_locus_tag="SAMN05661093_08775"
     CDS             4850..4993
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9C43_RS57100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05661093_08775"
                     /product="hypothetical protein"
                     /protein_id="WP_160097110.1"
                     /transl_table=11
                     /translation="MEEQILTIKPMLPADRTPVSNGVRISATPSAGLDECTLDRAPVDA
                     PD"
     gene            5001..6812
                     /locus_tag="B9C43_RS43010"
                     /old_locus_tag="SAMN05661093_08776"
     CDS             5001..6812
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03975.1"
                     /locus_tag="B9C43_RS43010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08776"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_084433466.1"
                     /sec_met_domain="TIGR03975 (E-value: 5.2e-167, bitscore:
                     551.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRTTLVCMPWHALSRPSLALGVLSSACRREGLMPPAEYHGGLRF
                     AEFLLDQTNGVVTPSDYAAVAETGFPHALGDWVFAGVVNGDEFGLDGMADYAARHGIAM
                     RTLRAMRDLAASFVELVVDEVLATDPELVGFSTTFMQNVPSLAVAKQLKHRRPELTVLF
                     GGGNCDGPMGVALHREFEFVDMVLRGEADETFPRLLRALDGDGELADVPGLCWRDTVNP
                     ARLVPPARMSAPHFEGWFGAFDASPVSRYAEPELVVESARGCWWGEHHHCTFCGLNGTS
                     MAFRAKPAETFVDEVDGLIRQHRVLDVMVVDNILAPGYLRTALPELARRGWDLRLHYEV
                     KANLTGAQIEVLRDAGVYSVQPGIESLVDDVLGRMNKGVRAVRNVRTLRDCESAGLTVA
                     WNWLYGFPGEREEDYKAVVDQLPALVHLQPPDGVTRIQLERFSPYFEDPSLGFPDRSPA
                     EAYRYVYALPAETLQDLVYLFDTTPRGLTEQQASPLWTAVRTWTAQHAASTLVRKHIDG
                     VTVLRDRRIGWPEEDHVLENPRQQRAWTELEYGRSLAGIARRLADAGLSWEVYDLARWL
                     SELCERGLLFTEGGYYVALATTWAGPR"
     misc_feature    6480..6482
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6809..7372
                     /locus_tag="B9C43_RS43015"
                     /old_locus_tag="SAMN05661093_08777"
     CDS             6809..7372
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.4"
                     /locus_tag="B9C43_RS43015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08777"
                     /product="DUF5825 family protein"
                     /protein_id="WP_084433171.1"
                     /transl_table=11
                     /translation="MNHWPDVTVLDTIPSNDADIDTADRNCQRFRLRVPLMFGANPAQD
                     AAALRFLVSAAERYVRVEWHLVGELPWPLHTVVHLPPPATADDAASDIARQWREQSGLA
                     LCTYRYGPDFVVLRDNRPGKDRFRGLLGADWVQPFRDLVARIAVDNRLLDELVAADLAI
                     RLGDGEHVVLAVRLLRWPVPYFAV"
     gene            complement(7377..8051)
                     /locus_tag="B9C43_RS43020"
                     /old_locus_tag="SAMN05661093_08778"
     CDS             complement(7377..8051)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102146.1"
                     /locus_tag="B9C43_RS43020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08778"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_084433172.1"
                     /transl_table=11
                     /translation="MAAEPTDTPRRNPLSKETVLRAAIELADEAGGGVPSMRKLAERLG
                     VEAMSLYHHFRNKDLILDGMIDTVFGEIELPQDDVGWQTAMRRRAVSMRGALIRHPWAI
                     SLMDSRTNPGHATLRHHNAVVGCLRAGGFSIAGAAHALSVLDSYIYGFVLQELSVPFKT
                     PVDLENVASSILDEMPRDEFPHLAEMIVDRALKPGYAYAEEFDIGLDLILDGLQRQREN
                     WA"
     gene            8255..8971
                     /locus_tag="B9C43_RS43025"
                     /old_locus_tag="SAMN05661093_08779"
     CDS             8255..8971
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102148.1"
                     /locus_tag="B9C43_RS43025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08779"
                     /product="DUF4386 domain-containing protein"
                     /protein_id="WP_084433173.1"
                     /transl_table=11
                     /translation="MSTPRGLARTAGLLYLIVASSTIFAGLVNSRIVESGNAAATAGNI
                     EASATLYRIGFVSELVGATAFLLTSMTLYLLLKHVNQMAAAAMVVFVAVSVAIQTLNLL
                     NQNTALTIATSQDYTTAFGQPVAAQLTMLFADMQSNGFLIAQTYFGLWLLPLGYLVMKS
                     GYFPKALGVLLVIGCCGHLVDVFSRFLAPDFGAGISPFALTFAAVAELSFIAWLLVKAP
                     VTYGRRRTAVAGRLDG"
     gene            complement(9059..9775)
                     /locus_tag="B9C43_RS43030"
                     /old_locus_tag="SAMN05661093_08780"
     CDS             complement(9059..9775)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227440.1"
                     /locus_tag="B9C43_RS43030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08780"
                     /product="heparin lyase I family protein"
                     /protein_id="WP_084433174.1"
                     /transl_table=11
                     /translation="METLRRFLAVPLTAVLALSLLANPAHAATIWSGDPSGGLRVFGNM
                     NCDSPGSVTAVDDPAHGRVWRYNKPSGSNRCENHGIAVGGKRYEFRNGSTYYLGWRSKL
                     SSAVNNNATFQWKSYGNHIQNFPVVLKVISGRISILQRQPGGVERITWSRPITANTWHT
                     YVLGLHLSSATTGGWVEFWFDGQKQTFTNNSQRWACRTWDSINEPKWGIYGASGTSVAN
                     YVDALKVGTAYSDVAP"
     gene            complement(9932..10804)
                     /locus_tag="B9C43_RS43035"
                     /old_locus_tag="SAMN05661093_08781"
     CDS             complement(9932..10804)
                     /NRPS_PKS="Domain: Abhydrolase_1 (23-276). E-value:
                     2.4e-19. Score: 61.9. Matches aSDomain:
                     nrpspksdomains_B9C43_RS43035_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.5"
                     /locus_tag="B9C43_RS43035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08781"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_160097112.1"
                     /sec_met_domain="PF00561 (E-value: 1.5e-12, bitscore: 42.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.2e-16, bitscore:
                     56.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFEEIVIRTDRLDFPALAVGDGPVVVCWHGFPDHPATFGPLAEH
                     LVAAGRRVVAPFLRGHHPVTADQMTYADSITLAADAAAVAEALSPDAGVDMIGHDIGAG
                     VVARLAGAWPERLRRGVTMAVPPPKALPPILLDPAQQQRFFYLWLFQLPNVAETVLESD
                     RRLIDYLWATWSPGLDPGEHRVRVHELYGDPTLLRNALRIYRGNFDMTLHDPELAALAA
                     RTEAPATVPLLVLAGADDGCIPPEHFANAQTGLAPGSSVQVVANAGHFMHLDQPGKVAK
                     AVLDWFSAD"
     aSDomain        complement(9977..10735)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9C43_RS43035_Abhydrolase_1.1"
                     /evalue="2.40E-19"
                     /label="B9C43_RS43035_Abhydrolase_1.1"
                     /locus_tag="B9C43_RS43035"
                     /protein_end="276"
                     /protein_start="23"
                     /score="61.9"
                     /tool="antismash"
                     /translation="PVVVCWHGFPDHPATFGPLAEHLVAAGRRVVAPFLRGHHPVTADQ
                     MTYADSITLAADAAAVAEALSPDAGVDMIGHDIGAGVVARLAGAWPERLRRGVTMAVPP
                     PKALPPILLDPAQQQRFFYLWLFQLPNVAETVLESDRRLIDYLWATWSPGLDPGEHRVR
                     VHELYGDPTLLRNALRIYRGNFDMTLHDPELAALAARTEAPATVPLLVLAGADDGCIPP
                     EHFANAQTGLAPGSSVQVVANAGHFMHLDQP"
     gene            complement(10862..11605)
                     /locus_tag="B9C43_RS43040"
                     /old_locus_tag="SAMN05661093_08782"
     CDS             complement(10862..11605)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1197:
                     autoinducer-binding transcriptional regulator,"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="B9C43_RS43040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08782"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_084433176.1"
                     /transl_table=11
                     /translation="MVDLAADDLRRALDFVGALYEDIDDVAIGSETLAILGDLVGCDLV
                     SATSMDHTDRRVLESTIDRTERESLLDRQGFAEAVSEHPGFGAYRSGALRLGTSVALTD
                     LAAPSVLRRFQFYVDFYRPEGTADQLVCAIRSTGRLGTVITFNRDRYGFSDRDRAVVDL
                     IAPHVSSALAVRERIAALRAPDVDLADCTPREREVIALVASGATDREVARALSISPRTV
                     HKHLERIYRKFDVTSRTSLIARLTS"
ORIGIN
        1 ctgtcaaccg tcgtgtgcgt cagctgccca tggaaagcct ctggagttaa cggccgtgcc
       61 gacacgtgca cgaacgcgtc acagacgacg tcggcccagt agccgaacgc ctctttgtcc
      121 ggaacgtccg cagtggacca cacagtctgc cccactcccc catcatgacc actgaccagc
      181 aacgatgcca attcccttgt ggacactggc gactagtcgc cgttctcgct tcgcggcctg
      241 accgaggcgc gaatacactg atcgtgtgca aaccgggact ggggtgcggt gggcgctggt
      301 atgtgcgggc acggcactga tcggtacctg ctatgggttc gcgcggttcg cctacggcct
      361 gttcgcgccc gagttccaga cgcaattcca gatctcctcc accgtttcgg gcatcattgg
      421 ttcgggcagc tacatcggtt actgcgtggc gattgtggcc agtcttgtgc tcaccgagcg
      481 gttgggtgcg cgcagaatcg cggtcagcgc gggtgtcgtg gcaacgttcg ggatcgccat
      541 gatcaccttt gccccttcgg cgcctgtgct cgcggcaggt gtgctcatcg ccgggtccag
      601 caccggcctg gcatccccac cgatggccgc ggcggtgagc cgatggattc acgccccagc
      661 gcaggatcgg gcgcaaagca tcgtcaacgc gggcacagga ctgggagttc tggtctccgg
      721 tccgatcgcg cttgccctga tcgacgagtg gcggtgggcg tgggcggtgt tcaccgtgat
      781 ctcagccgcc gtcacggtct ggctgtccaa ggcgatcccg ttcacggagt ccgaagggca
      841 caccgacaca gccggaaacg gttggcggcc aggcactttc ctactgatcg ccggggcttt
      901 cctgatgggg ttcagcagtg tcgcgatgtg gacgttcggc cgtgatctgg tcacctcggt
      961 cggtcatgtc agtgacgtcg tgtccacgtc gatgtgggca gtgctcggcg cagccggttt
     1021 cgtcggcgct ctcagcggcg atttggtcgc acgcgcaggg atggcccgct catggacgac
     1081 ggtgatggtg gcaatggcag gtgccacact gcttctcgcc ttcctgccag gtacccctgt
     1141 gcctattttc attgccgcag cggtgttcgg ggcctcatac gtgagcctgt gcggcgtgat
     1201 tctgttgtgg agcacccgga tctacccgca acgtccatct ttcggggtgg gcgtgtcatt
     1261 cctgatgatc gcagtcggcc aggtggccgg tgccccactg gccggggtgc tcaccgatgt
     1321 gtcgggtggc accgcggcgt tctacgcatg cgccgcgatc gggctcatcg gcgcttgtat
     1381 ccggccccgg ccgtcgtgac agcgaagccg cgcgtgagca gccatcctgc cagcaccatt
     1441 tcgttcagcg ccaacgggat gacgagtacg gaatggatcg ccgagaacgg cgcgagcgca
     1501 ccgaacatca ccagacctgc gtcggcgaga tacggcagca ccccgatcag cgcccagccg
     1561 gagatccacc ggggaacgag ccctgaccgg aacaacagca cgttgagaat cgccgcaccg
     1621 aggcagaaga agaccatgct gcccgggtgg ccccacacgt catacgtccc ggtcacgatc
     1681 cggacgatgt catcgggtgc gccggacagg ctcatgagcg gcccgacggt cgccggaagc
     1741 accagcacga cctcgagagt tctggccacg acgtagccga gcgcgagcgc ctcattgtgc
     1801 tccttgagga tcgggaacag caccggcggg atcatcgcga tcgcaacggc catgatcagc
     1861 accatcaagg ccgctgccga tgccggcgcg ctggcttgat cacctggccc gagcagcacc
     1921 gcgctgacca ctcccgcagc cgtcgccatg acgaaaaggg caccgaccac tcgtgctgac
     1981 gttttcctga ttgtcatggg cctcacggtc gacgacaccg gtgtgctgcc ggtgtgggcc
     2041 gggtttgctg agggtgtgcg ctgtgacagg cttggcggaa ggtcaacgtc tgggagcagc
     2101 gctgtggtgc ggatcggtct gctcggtggt gtccgcgtca cctccgacga cggcgagccg
     2161 gtcgatatcg gctcggcgaa gtcgcaggcg gtgctcgcgg cgctggccct gtcaccgggc
     2221 acgtccgtaa cggtgtcacg cctggtcgag cttgtctggg ctgacgagcc cccgcaaacc
     2281 gcgcacaagg cgctgcagtg gcacatcgcc cagttgcgta agggtcttgg ttccgaggcg
     2341 atcgtgcgcg tcggtgccgc gtaccgcctt gacgtagcgg ctgatgcggt cgatgtggct
     2401 cgtttccagc gccacttccg cgatggtgat ttcagcgcgg ccctcgccga gtggggcggc
     2461 actcccctgg ccggtctgga cgcaccaggc ctcgctgcgg cggtggctgg gctgaccgag
     2521 cagtggctga acgcggtcga agcggacctt gagcggcgag tcggaaacga cccgcgaggc
     2581 gtcatcggtt cgcttgcgga gctcgcggaa cgctatccac tgcgcgaaaa cgtgtgggcc
     2641 ctgctgatga ccgcgctgta ccgtgtggac cgtcaggcgg acgctctcgc ggcgttccgg
     2701 caggcacggc accatctcgt cacggaactc ggcgtcgaac ctgggcccgc gttgcgtgag
     2761 ctcgagtcgc ggatcctcga ccaggacacg cgcctgcgcg aacgtgccgc acatgagggg
     2821 tacgtacccc gtcgcgtggg accgctcttc ggccgcgacg aggacctaca ggccatcgcc
     2881 gacgccctgg cgcgatcagc tgtcgtgact ttggtgggac cgggcggaat cggcaagacc
     2941 cagctcgcgc tggcagcagc cgccgatcac ggacagctga tcgagttggc ggagatcacc
     3001 tcgcccgccg acgtgccccg cgcggtcgcc gacgcactgg gtgtcgcgca gcgtcagggc
     3061 cgcaccttga cccagtcgat cgtcgcggcg ttccggtcac gttcggcact gctggtcgtc
     3121 gacaactgcg aacacgtcat cgacggcgcg gccgaactca tccgagccgt cgtgtccggc
     3181 tgcccgcagg ttcacgtcct cgccacgtca cgggaacgtc tttcccttgc agcggaacag
     3241 gtactggccg tcgggccgct ggacctccac gccggtgccg agctgttcaa cgcccgcgcg
     3301 accgccgcgg atcgaactta tgacgctgct gcgcatcggg atcacgtcac ggagatctgc
     3361 cgtcagcttg acgggattcc gctggccatc gagctggccg cggcacggac gatcagccat
     3421 cagcccgccg acctcgtcgc caggctcaac gaccgcctgc gggcgaccgg cagccgcagg
     3481 accggcgccg cgcggcatcg cacgttgcgg gcagccatcc agtggtcata cgacctgctc
     3541 acccccgccg aacagacgct gttccaacag ctttcggtgt tcagcgcccc gttcgacctc
     3601 agcgcggcgg aagcagtggc tgacggcgcg gacggcctga tcagcgctct ggtcgagcgg
     3661 tcggtgatca ccgtcgacaa tggaccattt ggacggcgtt tccgtttgct ggagccgatg
     3721 cgtcagttcg ccgccgaaca cttgcgggac cgggacgtca tcgccgaacg tcatgcccgt
     3781 tggtgcgtca gcgaagtcac ccacatccac cgtctgctca ccggaccgga cgagatcgaa
     3841 ggcgtcgccc ggctcgccga gctctggccg aacctgcgcg cggcggtcac atggacgcga
     3901 gacgtcggtc tggccgacgc actggtccgg ccgatcgtca ctgaactgcc cttgcggggg
     3961 cggcaggaaa tcggcgtgtg ggccgaacac atcctggcca tgacgtcaga tgcggacgtg
     4021 cgcgccttct ggctcgtctg ggtcgccgaa cgctacaccc agaacgccaa tccggcgggc
     4081 tatcgcgagg tcgccgagca ttacggcacg gaccggccgc tgagccgcta cgccgacgcg
     4141 tacgcctgcg gcgacggcga ggctttgtgg cagtgtctgc cggatgccgt cgctggtctg
     4201 cacagcgatg atctggctgc cttcctcgaa atgacgtccg cggggatttt gctgggcacc
     4261 gggcgcttcg agcaggtcga caaatcggtc acggtcctgg cggatcggta tcgagtccac
     4321 ggcccgccaa cgctcctgca ctgggcgctg cagaccctcg gctatcgcgc gtcgttccag
     4381 ggcagagccg aggacgccga ccggtatttc gacgaagcgt cccgtgtcag cctgcccgcg
     4441 ggcacgctct cggccaacaa gagcaccgaa gcccggtcgg ctttccggcg cggcgagcga
     4501 cagcgagcgt tccaactcct gcgctcccac atcgacgaac tgatcgacac cgacaacgtg
     4561 gtcgcggcca gcatcgtctg catcgagttc gtcaccatga tggccaagat cgaccggatc
     4621 accgaggccg cccacatgct caggtacctc aaggctgtca acgagttcgg cgcgttggcc
     4681 gccagaactc tcgtcgcgga ggccgcgacc aggatcgctg agcacagcgc cgatacgaca
     4741 ccggccgtcg acgaccgcgc ggcgctcgcc tacatgcgcg acgtcctcgt cgaactcgag
     4801 tgaccgggaa gtgacccgga agtgagcacc ccggggcagc atgcgcgtca tggaagaaca
     4861 gatcctgacg atcaagccga tgctgccggc tgaccgcacg ccggtgagca acggtgtacg
     4921 catcagcgcc acaccatcag ccggactgga cgagtgcaca ttggaccgcg ccccggtcga
     4981 tgcgcctgac tgatcaggcc atgcccagga cgactcttgt ctgcatgccg tggcacgcgt
     5041 tgtcgcgacc cagtctggca ttgggcgtgc tgagttccgc gtgccgacgc gaagggctca
     5101 tgccgcccgc cgagtaccac ggcggactgc ggttcgcgga gttcctgctg gaccagacca
     5161 acggcgtggt gactccgtcc gactacgcgg cggtcgccga gaccgggttc ccgcacgcgc
     5221 tgggcgattg ggtgttcgcg ggtgtggtga acggcgatga gttcggtctc gatggcatgg
     5281 cggattacgc cgcacggcac gggatcgcca tgcgcacact gcgcgcgatg cgcgacctcg
     5341 ccgcgtcctt tgtcgaactt gtcgttgacg aggtactggc cactgacccg gagctggtcg
     5401 ggttcagcac cacgttcatg cagaacgtgc ccagcctcgc cgtggcgaag caactcaagc
     5461 accgcagacc ggaactgacc gtgctcttcg gtggcggcaa ctgcgacggg ccaatgggag
     5521 tggcgctgca ccgtgagttc gagttcgtcg acatggtgct gcgtggcgag gccgacgaga
     5581 cctttccccg gctgctgcgg gctttggacg gcgacggcga actcgccgac gtgccagggc
     5641 tgtgctggcg cgacaccgtc aatcccgctc ggctggtgcc accagcacgc atgagcgcac
     5701 cgcacttcga gggttggttc ggtgcgttcg acgcctcacc ggtgagccgg tacgccgaac
     5761 cggaactggt ggtggaatcc gcgcgcggat gctggtgggg cgaacaccac cattgcacgt
     5821 tctgcgggct caacggcacg tcgatggcct tccgggccaa gcctgccgag accttcgtcg
     5881 acgaggtgga cggcctcatc cgacaacacc gggtactcga cgtgatggtc gtggacaaca
     5941 tcctcgcacc gggctatctg cgcactgcgt tgccggaact tgccaggcgg gggtgggacc
     6001 tgcgcttgca ctacgaggtg aaggcgaatc tgaccggggc gcagatcgag gtgctgcggg
     6061 acgccggtgt gtacagcgtc caacccggca tcgagtcgct cgtcgacgac gtgttggggc
     6121 ggatgaacaa aggtgtccgg gctgtccgca acgtccgcac gttgcgcgac tgcgaatcgg
     6181 ccgggctgac tgtggcgtgg aattggctct acggctttcc tggtgagcgg gaagaggact
     6241 acaaagcggt ggtcgaccaa ctgcctgcgt tggtccactt gcaaccgccg gacggggtga
     6301 cacggatcca gctggaacgc ttcagtccgt acttcgagga tccgtccctc gggttcccgg
     6361 atcggtcgcc tgcggaggcg taccggtacg tgtacgcgtt gccggcggaa acgttgcagg
     6421 acttggtcta cctgtttgac acaactcccc gtggtctcac cgagcagcag gccagtcctt
     6481 tatggaccgc agtgcggacg tggacagccc agcatgccgc gagcaccctt gtgcgcaaac
     6541 acatcgacgg cgtaaccgtg ctgcgcgacc gccgcatcgg gtggccggag gaagaccacg
     6601 tacttgagaa tccccggcaa cagcgagcgt ggacagaact ggagtacggc cggtctttgg
     6661 cgggcattgc ccgccggctc gccgacgcgg gactgagctg ggaggtctac gacctggcac
     6721 gctggctgtc cgagttgtgc gagcgcggcc tgttgttcac cgagggcggg tactacgtcg
     6781 cgctcgccac gacctgggcg ggtccccgat gaatcactgg ccggacgtca cggttctgga
     6841 caccatcccg tcgaatgacg ccgacatcga caccgcagac cggaactgcc aacgctttcg
     6901 gttgcgtgtc ccactgatgt tcggagcgaa ccctgcgcag gacgcggccg cactccggtt
     6961 ccttgtctcg gccgcggagc ggtacgtacg ggtcgagtgg caccttgtcg gcgagttgcc
     7021 gtggcccttg cacaccgttg tgcacctgcc gccaccggcc acagcggacg atgcagccag
     7081 tgacatcgca cggcaatggc gggaacagtc cggtctggcc ctgtgcacct accggtacgg
     7141 cccggatttc gtggtgctgc gcgacaatcg ccctggcaag gatcgtttcc gcggcctttt
     7201 gggtgccgac tgggtgcagc cgttccgcga cttggtagcg aggatcgctg tggacaaccg
     7261 gttgcttgac gaactggtgg ccgcggatct tgcgatacgg ctgggcgacg gcgaacacgt
     7321 cgtgctggcc gtgcggctgc tccgctggcc ggtgccctat ttcgccgtct gatcgcctag
     7381 gcccagtttt cgcgctggcg ctgcagtccg tccagaatca ggtcaaggcc gatgtcgaac
     7441 tcctcggcgt acgcgtaacc aggcttcagc gcacggtcga cgatcatctc ggcgaggtgc
     7501 gggaactcgt cgcggggcat ctcatccagg atcgagctcg ccacgttctc caggtcgacc
     7561 ggggttttga acggcacgct gagctcctgg agcacgaacc cgtagatgta gctgtccagc
     7621 accgagagcg cgtgtgccgc accagcgatc gagaagcctc cagcccgcag gcacccgacg
     7681 accgcgttgt ggtgtcgcag agtcgcatgg ccaggattgg tccgtgagtc catcaggctg
     7741 atcgcccacg ggtggcggat cagcgcgcca cgcatagaca ctgcccgcct gcgcatcgcg
     7801 gtctgccagc cgacgtcgtc ctgcgggagc tcgatctcgc cgaagacggt gtcgatcatg
     7861 ccgtcgagga tcaggtcctt gttgcggaag tggtggtaca gcgacatcgc ctcgacaccg
     7921 agccgctcgg cgagtttgcg catgctcggc acgcctccgc ccgcttcgtc cgccagctcg
     7981 atggccgcgc gaagaaccgt ttccttgctg agcgggttgc gtcgaggcgt gtcggtcggc
     8041 tcggcggcca caaggtcctc ccgtctgact gcttgacaac cttacaccat aaggctgtac
     8101 cttacggcgt aaggccagac gcacggttgt tcccgtgtgg ctggcacatc atccgcggcg
     8161 gaaaggacgt gtacgtggac tacgcgcagt tcatggtcga ggccattgtc ggccggctgg
     8221 ccccatcgac cctcgctcac gccggcgagc cagcatgagc accccacgcg ggctcgcgag
     8281 gaccgcgggg ttgctgtact tgatcgtcgc ctcgtccacc atcttcgccg ggctggtgaa
     8341 ctcgcggatc gtggagtcag gcaacgcagc ggccacagca ggcaacatcg aagcgtcggc
     8401 gacgctgtac cgcatcggct tcgtcagcga actggttggc gccacggcct ttctgctgac
     8461 gagcatgacg ctgtacttgc tgctcaaaca cgtcaaccag atggccgccg cggcgatggt
     8521 cgtcttcgtc gccgtcagcg tcgcgatcca gactctgaac ctgctcaacc agaacacggc
     8581 gctgaccatc gccaccagcc aggactacac cactgcgttc ggccaaccag tcgccgccca
     8641 gctgaccatg ctgttcgccg acatgcagag caacggattc ctcattgccc agacgtattt
     8701 cggcctgtgg ctgctgccgt tgggctacct ggtcatgaag tcgggctact tccccaaggc
     8761 gttgggcgtc ctgctggtga tcggatgctg cgggcacctc gtggacgtgt tctcccgctt
     8821 cctcgcaccg gactttggcg ccggcatctc accgttcgcc ctgaccttcg cggccgtcgc
     8881 ggaactttcg ttcatcgcat ggcttttggt caaggctcct gtcacttatg gtcgccgtag
     8941 gactgcagta gccggtcggc ttgacggatg atgtgaacca cgcaacgcgg gcacgcccga
     9001 agcgcccacc aggccacagc agacctcggg tcagtggatg gtcgacctgg tgttcgtctc
     9061 agggtgcgac gtcggagtag gccgtcccga ccttgagagc gtcgacgtag ttggcgacag
     9121 acgtgccgct ggcaccgtag atgccccact tgggttcgtt gatgctgtcc cacgtacggc
     9181 aagcccagcg ctgcgagttg ttggtgaagg tctgtttctg gccgtcgaac cagaactcga
     9241 cccacccgcc ggtggtcgca ctggacaagt gcaggcccag cacataggtg tgccaagtgt
     9301 tcgcggtgat cggccgggac caggtgatgc gttcgactcc cccgggttgc cgctgcagga
     9361 tggagatccg gccgctgatc accttgagca cgacgggaaa gttctggatg tggttgccgt
     9421 aggacttcca ctggaaggtg gcgttgttgt tcaccgcgct ggacagtttg ctccgccagc
     9481 cgaggtagta ggtcgacccg ttccggaact cgtaccgctt gcccccgaca gcgatgccgt
     9541 ggttctcgca ccgattgctg ccactgggtt tgttgtaccg ccaaacccga ccgtgggcgg
     9601 ggtcgtcgac tgccgtcacg ctgccgggcg agtcgcagtt catattgccg aacacgcgca
     9661 acccgcctga cggatcaccg ctccagatcg tcgcggcgtg cgccggattc gccagaaggg
     9721 acagcgccag caccgccgtc aacggcacag cgagaaatct acgcagagtt tccatccgcc
     9781 atcgaacctt tcatgcgaag gttgcggcgg acactgtgca ttatttcggc cgtgtcaacc
     9841 gcacaccggc agcggttcgg catcatcgga ttcgatcttc aactcgtcgg cacggaccgc
     9901 cagctacggc cagcactggt gtgcagcggt gtcagtcggc ggaaaaccag tccaggacgg
     9961 ctttggcgac cttgcccggc tgatcgaggt gcatgaagtg acctgcgttc gccacaacct
    10021 gcaccgacga gccgggagcc agacctgttt gtgcgttggc gaaatgctca gggggaatgc
    10081 agccgtcatc cgcgccggca agtacgagca gcggcactgt tgctggtgct tcggtccgag
    10141 cggccagtgc ggccaactca ggatcgtgca atgtcatgtc gaagttgccg cgatagatcc
    10201 gcaatgcgtt acgcaacagc gttggatcac cgtagagttc gtgcacccgc acccggtgct
    10261 cgccgggatc caggccgggc gaccatgttg cccagaggta gtcgatcagt cgccggtcac
    10321 tttccagcac ggtttccgcc acattcggca gctggaacag ccacaggtag aagaaccgtt
    10381 gctgttgtgc cggatcgagg agtatcggcg gcagagcctt gggcggtggc acggccatcg
    10441 ttacgccgcg gcggagtcgt tcgggccagg cgcccgccag ccgggccacc acgcccgcgc
    10501 cgatgtcatg tccgatcatg tcgacaccgg cgtccggcga cagtgcctcg gcgaccgcag
    10561 cggcgtcggc cgcaagcgtg atgctgtcgg cgtaggtcat ctggtccgct gttacgggat
    10621 ggtggccgcg gaggaacggc gcaaccactc ggcggcctgc ggcgaccagg tgctcggcga
    10681 gcggcccgaa ggtggcgggg tggtcgggaa agccgtgcca gcacaccaca actggcccat
    10741 cgcccacggc gagcgcggga aagtcaagtc ggtccgtgcg aatcacgatc tcttcgaagt
    10801 ccacagccgc aatctatcgc ccagtcgccg tacggacgcc tggttccggc gatcccgctg
    10861 atcacgacgt cagccgggcg atcaggctgg tgcggctggt cacgtcgaac ttccggtaga
    10921 tccgttccag gtgcttgtgc acggtgcgcg ggctgatcga cagggcacgg gcgacttcac
    10981 gatcggtcgc ccccgaggcg acgagggcga tcacctcacg ttcgcgtggt gtgcagtccg
    11041 cgagatccac gtcgggcgca cgtagcgccg cgatgcgctc acggaccgcg agtgctgagg
    11101 acacgtgggg cgcgatgagg tcgaccacgg cgcgatcacg gtcggagaag ccgtatcggt
    11161 cccggttgaa ggtgatcacc gtgcccagcc tgccggttga ccggatcgcg cagaccaatt
    11221 ggtcggcggt gccctccggc cggtagaagt ccacatagaa ctgaaaccgg cggagtacgg
    11281 acggcgcggc cagatcggtc agcgccaccg acgtgcccag ccgcagcgcg cccgaccgat
    11341 aggccccgaa ccccgggtgc tcgctcaccg cttcggcgaa cccttgcctg tccagcaagg
    11401 attctcgctc cgttcggtcg atcgtcgact cgagcacccg gcggtccgtg tggtccatcg
    11461 aagtcgctga caccaggtca cagccgacca gatcgcccag gatcgccagg gtttccgacc
    11521 ctatggcgac atcgtcgatg tcctcgtaca gcgcaccgac gaaatccaac gccctacgca
    11581 ggtcgtcagc agccaagtcc accatgtgct cccctcagac agaagtcccc acggaaaaga
    11641 ggcgcccggc gccggtttga tactccgcaa aattgcgtat tgcccgggag ttccgccgct
    11701 tggtgtcgta tggccccgac cacgccaccg agcggaagta ccggttgccc atgaaccacg
    11761 cgaacagatt catcctggtc cggccgagcg accaggtacg cgtcgaagtc ga
//
