LOCUS       NZ_FWXV01000009        10795 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Kibdelosporangium aridum strain DSM 43828, whole genome shotgun
            sequence.
ACCESSION   NZ_FWXV01000009
VERSION     NZ_FWXV01000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kibdelosporangium aridum
  ORGANISM  Kibdelosporangium aridum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Kibdelosporangium.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900176515.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:02:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,283
            CDSs (total)                      :: 11,193
            Genes (coding)                    :: 11,032
            CDSs (with protein)               :: 11,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 3, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 38 of 161
            Pseudo Genes (incomplete)         :: 135 of 161
            Pseudo Genes (internal stop)      :: 6 of 161
            Pseudo Genes (multiple problems)  :: 17 of 161
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:58:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 398984
            Orig. end                         :: 409779
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FWXV01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10795
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10795
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10795
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5795](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5795)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(43..58)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.27"
                     /tool="antismash"
     gene            complement(110..427)
                     /locus_tag="B9C43_RS59720"
                     /old_locus_tag="SAMN05661093_08176"
     CDS             complement(110..427)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039409.4"
                     /locus_tag="B9C43_RS59720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08176"
                     /product="DUF6328 family protein"
                     /protein_id="WP_268811609.1"
                     /transl_table=11
                     /translation="MLQPHRLAARRPRRCPAASAAPKAPAAFHQAVFQRRVKDHLARYS
                     TRFALSGLGQLMLALTSALLLLVTVVLGLHVGSWLAGGALAWFVFVWYLLPLRSRVRTR
                     R"
     gene            complement(316..633)
                     /locus_tag="B9C43_RS59725"
     CDS             complement(316..633)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039409.4"
                     /locus_tag="B9C43_RS59725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6328 family protein"
                     /protein_id="WP_327224400.1"
                     /transl_table=11
                     /translation="MSLVHIRDIMHSCTATSANTTAGTSPYEQEAGSSGSAGTTARIPR
                     KLRVARTGVQSLLAFPLTVAFTPRFSSLTGLPRDVHVAARQPARRRRPRQPFTRRCSSA
                     G"
     misc_feature    complement(463..465)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(719..3805)
                     /locus_tag="B9C43_RS40090"
                     /old_locus_tag="SAMN05661093_08177"
     CDS             complement(719..3805)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.5"
                     /locus_tag="B9C43_RS40090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08177"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_084432626.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6.3e-65, bitscore:
                     214.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEDAYSVHAIIPGKGREKLAFSTYKRDGHHYVVPQDAVSLIAQG
                     RVDERLFDVTLLSESDYRDGERNNTLPLIVSHAPGASIAGATTTANLAAINASAVTATK
                     GGAAWQSLTGATVKKVWLDGKRKASLDRSTAQIGAPAAWDAGFTGEGVKVAVLDTGVDQ
                     THPDLATREVAEKNFSDSPDAVDRYGHGTHVASTIAGTGAKANGKYKGVAYGANIIDGK
                     VLADGGYGYDSWIIGGMQWAVEQGAKVVNLSLGGGDTPDIDPLEEAVNTLSAKHGTLFV
                     IAAGNSGPREETVGSPGSADAALTVGAVDRDETLAPFSSRGPRIGDAAIKPDVTAPGVN
                     IAAAKAANGQMGTPVADGYVAASGTSMATPHVAGAAALLAQVHPDWSGEQIKATLTASA
                     KPNGKLNAFQQGSGRIDVAKAVTQAVTTTPTSISLGTQLWPHDDDQPVNKGLTYRNTGK
                     TDVTFDVTVNALGPDGKAAPAGLLTASPAKVTVPAGGEATVTITGNTKLEALDGIYSGT
                     LTATAGDLTVNTPVAINREPESYTLTINHIGLDGAPATGYRTALFGLDSGKYTSAFDPD
                     GSPSLRLPKGSYAVDSSLVGQQAINWLAFPAFTLTEDTTIDLDFRRTKPTKVTPVDPAS
                     LMRLADVTYQRIAGKTSFGFGWVLFGGDLSTLHTAHVGPELSPQELLTQINTQWDTPAG
                     DYYGLAFYQHGSMPTGFTKAVKKETLAHVHGTFGATVPGKSGLRYAFPYPKFGTGPGAW
                     AVLLPVKLPGERNEYYTTEDAAWSPGLYQLSADGRTLEAQLASPVKVFQGGRTYEESYN
                     RGVFAPVMPQTRFPNQYVTRTENKISVNIPLFGDASGNAGSSLVDKGSTVLYRDGKKIG
                     ESPNPAYGQFDVPADTGTYTLTAEAIRSGVSDVSTTVRGAWTFRSGPAGADPVRLPLST
                     VRYTPALDATNSAPAGESFIVPVSVQAQNSGQGTVPKSLTVEASFDGGQTWTAATVVAN
                     VFAIVQHPNDATSVSLRAKATDRAGNTVEQTIINAYKLN"
     gene            complement(4128..4637)
                     /locus_tag="B9C43_RS40095"
                     /old_locus_tag="SAMN05661093_08178"
     CDS             complement(4128..4637)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9C43_RS40095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05661093_08178"
                     /product="hypothetical protein"
                     /protein_id="WP_084432628.1"
                     /transl_table=11
                     /translation="MNRNLTAALALACTVLTGCGSTLQGAGVPCSGAAIRKGISLDIDP
                     AYAPKVGSARLTACWNGSCQDKDLELYPSTAASALPCTPTGPDTACGARMEPTGGKNSF
                     ADLPELPAGPVEVTLRLIDPARAEIGAPRLTVSPKVRYPSGPDCGGGTPQGGVLVSPDG
                     TVSERP"
     misc_feature    4633..4648
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.25"
                     /tool="antismash"
     gene            complement(4654..5004)
                     /locus_tag="B9C43_RS40100"
                     /old_locus_tag="SAMN05661093_08179"
     CDS             complement(4654..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099301.1"
                     /locus_tag="B9C43_RS40100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08179"
                     /product="hypothetical protein"
                     /protein_id="WP_084432630.1"
                     /transl_table=11
                     /translation="MTQPQRDRLAEQQAQLLHALLAEGPPPPGFDPRRLEVEAKALRSK
                     RRQIVAMIEPDVCADLEDRFVPLFTEYAKAHPRKDGSRMRDDAWAFVEWLRAEGHLPKV
                     RWWQRRRATKNR"
     gene            complement(5001..5795)
                     /locus_tag="B9C43_RS40105"
                     /old_locus_tag="SAMN05661093_08180"
     CDS             complement(5001..5795)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983665.1"
                     /locus_tag="B9C43_RS40105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08180"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_084432632.1"
                     /sec_met_domain="DUF692 (E-value: 1.1e-83, bitscore: 275.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDALGVGIGWRSEIDITVERLPGVDFVEVVAENLNPDRLPESVVL
                     LRERGLPVLPHAVSLSVGGAQPVDMKRVEHLARLADVLDAPVASDHVCFVRAGGLDSGH
                     LMPVPRTREALDVLVANVKTVQANLDVPFALENIAALLEWPDVELTEAQFLGELTERTD
                     CLLLVDVANMYANARNLNQDPVKLLDELPLERVAYVHVAGGEEHNGVYHDTHTHPVLPE
                     VLDLLAELVKRTKPPGVLLERDGDYPSDADLAAELQAIRERL"
     gene            complement(5799..6524)
                     /locus_tag="B9C43_RS40110"
                     /old_locus_tag="SAMN05661093_08181"
     CDS             complement(5799..6524)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="B9C43_RS40110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08181"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_084432634.1"
                     /transl_table=11
                     /translation="MTEFWLHLGVVVIATIATLVLRARLRSVDVPLAGLSPTVEDVAFL
                     QAGWQRMVETSIVTLSERKAIRIGREGVLSLGSRRNVKPRTELERVILGRVEAGTTINR
                     LKVTLQHHDAIKQAEMSLAQRGLLLRLTPIHLLKAASPLIVAAALGVVLFDPLLLVVTF
                     VVLIAALVPQRWMPYEIKRTTAGRYVIKTTEGTDAATLVALGGLANYPGPVAAKALRSK
                     VIDKDSPWSSGIGCGSGGV"
     gene            complement(6525..7415)
                     /locus_tag="B9C43_RS57845"
                     /old_locus_tag="SAMN05661093_08182"
     CDS             complement(6525..7415)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="B9C43_RS57845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08182"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_084432636.1"
                     /transl_table=11
                     /translation="MENPWGLSGPEFLWLYIGGLLVAGVVTVLLRRRIRSASTQRSHEP
                     LTVDETAFLSGGWVRVVESALANLVERNVIRVQRNGLLYPVSDTTARPESVLEERLVNR
                     ITKRQGRPLHYHLASMTNLPEYEAISTSLADKGLYYYGSSRRQVFVAALPLVALLVIGI
                     ARWINGINLGFPVGYLTGLLILTVIATLFAMREIKAGPTRAGRQALDERGNAVEAAATA
                     VARHGMRGYPDVTISRLLQEPRRVRSSRSRGSAYAGTSVATYGFFGGGGGDSSGGGGGS
                     SCGGGGGGGCGGGGS"
     gene            complement(7487..8194)
                     /locus_tag="B9C43_RS40120"
                     /old_locus_tag="SAMN05661093_08183"
     CDS             complement(7487..8194)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="B9C43_RS40120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08183"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_407657152.1"
                     /transl_table=11
                     /translation="MLTRSGAATTTAPIQALSAQELACLTGGPRRVVEAAVAQLVDTGQ
                     LRASRDGYLQLVGRSGGGDPVERTVVADVSRHGRRSISILTRRLAESDAVEEVVARLVG
                     AGYLVDDELAKRRKVISLVPVVVVFSVGVVRWLEGAAGDRPVGWLTVLLICSGVIGYAM
                     YRQAICPRTFEGANAVGRASVTAPAELVAAGGFTRHPDRMIRDALTGRRGVTSGGMSGC
                     VPISCGTEGNCKG"
     gene            complement(8404..8844)
                     /gene="msrB"
                     /locus_tag="B9C43_RS40125"
                     /old_locus_tag="SAMN05661093_08184"
     CDS             complement(8404..8844)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684638.1"
                     /locus_tag="B9C43_RS40125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08184"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_084432640.1"
                     /transl_table=11
                     /translation="MKPVTGVTPRVVKSDQEWREQLTAEEYAVLRKAGTERAFTGEYTD
                     TKTVGVYACRACGAELFRSSTKFDSHCGWPSFFSPLAGDAVILREDASLGMVRVEVLCA
                     TCHSHLGHVFEGEGYPTPTDQRYCINSISLTLRPDDGPDQQS"
     gene            complement(8851..9156)
                     /locus_tag="B9C43_RS40130"
                     /old_locus_tag="SAMN05661093_08185"
     CDS             complement(8851..9156)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800404.1"
                     /locus_tag="B9C43_RS40130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08185"
                     /product="hypothetical protein"
                     /protein_id="WP_033391977.1"
                     /transl_table=11
                     /translation="MAVNASPDEPASQRFREDLEGLDPHDPEVKAFAAHLERIETSRSG
                     YTVEGYLGGISDFADSANRLGGHYRMLALLFIGLILIGVGVAVWDSLVFILTSFGG"
     gene            complement(9174..10436)
                     /gene="hisS"
                     /locus_tag="B9C43_RS40135"
                     /old_locus_tag="SAMN05661093_08186"
     CDS             complement(9174..10436)
                     /EC_number="6.1.1.21"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004821 - histidine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006427 - histidyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684636.1"
                     /locus_tag="B9C43_RS40135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_08186"
                     /product="histidine--tRNA ligase"
                     /protein_id="WP_084432796.1"
                     /transl_table=11
                     /translation="MDNSPARGTRDLLPATVAVRDHVLARITEVYHRYGYQRIETPAIE
                     NIERLTGGQGGENEKLIYKILRRGLTELPDSLDELADLGLRFDLTVPLTRFYGNNHAAL
                     PVPFRSFQFGPVWRAEKPQKDRYRQFNQCDIDLIGEESVLAEAELIEATTDALAAAGLP
                     GTTVRLSDRRFLSALAEGAGVAPEAQGSFFITLDKLDKIGWDGVRKELTERAGFTAAQV
                     DGVQTAITALQGLDPAKLTDQLTDAVPNLAENVAEDLVTTTTALAELATTRELGWEFDP
                     TLVRGMGYYTGQIFEISHPGTSASVAGGGRYDKLIGRSLGKDVPACGFSIGFERIVNLL
                     DNAPRTDAVAVLHEADVTPAEVLAVARRLRAEGRQVTTIKRRGKFGTQLGRLEEWGYTS
                     FVHVRSGDVADERGLGSRESS"
ORIGIN
        1 ccaccccgaa gtcactggga acacctcgtc gtagcgtcgg gggtttccat gtcgagatgt
       61 tcgaagcgag gggctcaggc tggcacccgc cccggatccg cgactttcct catcggcggg
      121 ttcgtaccct gctccgcaac ggcagcaggt accaaacgaa cacgaaccac gccaacgcgc
      181 cgcctgccag ccatgagccg acgtgcaagc cgagcacgac ggtcacgagc agcagcagtg
      241 ccgacgtcaa cgccagcatc agctggccaa gcccggacag cgcgaatctg gtggaatatc
      301 gggcaaggtg atctttcacc cggcgctgga acaccgcctg gtgaaaggct gccggggcct
      361 tcggcgccgc gctggctgcc gggcagcgac gtggacgtcg cgcggcaagc cggtgaggct
      421 ggagaatctc ggggtgaagg ccaccgtcag cgggaacgcg agtaacgact gcaccccggt
      481 ccgcgccacg cggagctttc gcgggatcct cgcggtggtt ccggccgagc cactggatcc
      541 tgcttcctgc tcgtacggcg aggttccagc ggtcgtgttc gccgaggtcg cggtgcatga
      601 atgcatgatg tctcgaatat gaacgagaga catcggtcag ttgacgtaga tcggaagaag
      661 ggggcggagc ggccccgggt gtgggggcag gcccgaagcc gctccgcggg tgaacaggtc
      721 agttgagctt gtacgcgttg atgatcgtct gctcgacggt gttgcctgcc cggtcggtcg
      781 ccttggcccg caacgacacc gaggtggcgt cgttcgggtg ctggacgatg gcgaacacgt
      841 tcgccacgac tgtcgccgca gtccacgtct ggccgccgtc gaacgacgcc tcgacagtca
      901 gcgacttggg caccgtgccc tgtccgctgt tctgcgcctg cacggacacc ggcacgatga
      961 acgactcacc cgccggggcg gagttcgtcg cgtccaacgc gggcgtgtac cgcacggtgg
     1021 acaacggcag ccggaccggg tccgcacccg ccgggccgga ccggaaggtc cacgcaccgc
     1081 ggaccgtcgt ggacacgtcc gagacgccac tgcggatcgc ctcagcggtc agtgtgtacg
     1141 tgcccgtgtc ggcggggacg tcgaactggc cgtacgccgg gttcggcgac tcgccgatct
     1201 ttttgccgtc gcggtaaagc acggtcgacc ccttgtccac aagggacgaa ccggcgttgc
     1261 cggaggcgtc accgaacagc gggatgttga ccgagatctt gttctccgtg cgggtgacgt
     1321 actggttcgg gaaccgcgtc tgcggcatca ccggggcgaa cacgccacgg ttgtacgact
     1381 cctcgtacgt cctcccgccc tggaacacct tcaccgggct ggccagctgt gcctcaaggg
     1441 tccggccgtc cgcactcagc tggtacagac cggggctcca ggccgcatcc tcggtcgtgt
     1501 agtactcgtt gcgttcccca ggcagtttca ccggcagcaa gaccgcccaa gcgcctgggc
     1561 cagtaccgaa cttcgggtac gggaacgcgt accgcaggcc cgacttgccc ggcacggtcg
     1621 ccccgaaggt gccgtgcacg tgcgcgagag tctccttctt caccgccttg gtgaagccgg
     1681 tcggcatgga accgtgttgg tagaaggcca acccgtagta gtcaccagct ggcgtgtccc
     1741 actgggtgtt gatctgggtc agcagttcct gcggggagag ttcgggaccg acgtgcgcgg
     1801 tgtgcagcgt gctcaggtct ccgccgaaga gcacccagcc gaagccgaag ctggtcttgc
     1861 ccgcgatccg ttggtacgtc acgtcggcga gccgcatcag cgacgccgga tccaccggtg
     1921 tcaccttggt cggcttggta cgccggaagt ccaggtcgat cgtggtgtcc tcggtcagcg
     1981 tgaacgccgg gaacgccagc cagttgatgg cctgctggcc gaccagcgaa ctgtcgaccg
     2041 cgtagctgcc cttgggcaaa cgcagtgacg ggctgccgtc cggatcgaac gccgaggtgt
     2101 acttcccgga gtccaagccg aacagtgcgg tgcggtagcc cgtcgcgggc gcgccgtcca
     2161 gtccgatgtg gttgatggtc agcgtgtagc tctccggctc gcggttgatc gccaccggcg
     2221 tgttgaccgt gaggtcaccc gcggtcgcgg tcagcgttcc ggagtagatg ccgtccagcg
     2281 cttcgagctt ggtgttgccg gtgatggtca ccgtggcctc gccaccggcg ggcacggtca
     2341 ccttggcggg ggaggcggtc agcagaccgg ctggcgcggc tttgccgtcc gggccgagcg
     2401 cgttgaccgt gacgtcgaac gtgacgtccg tcttgcctgt gttgcggtag gtcaggccct
     2461 tgttgacggg ctggtcgtcg tcgtgcggcc acagttgcgt gccgaggctg atgctggtcg
     2521 gcgtggtcgt cacggcctgc gtgaccgcct tggccacgtc gatccggccg gatccctgct
     2581 ggaacgcgtt gagcttgccg ttcggcttcg cggacgcggt cagcgtcgcc ttgatctgct
     2641 cgccggacca gtccgggtgc acctgcgcga gcagggctgc ggcaccggcg acgtgcggcg
     2701 tggccatgga tgtgccggac gcggcgacgt aaccgtcggc gactggcgtg cccatctgac
     2761 cgttggcggc cttcgccgcc gcgatgttga cgccgggtgc ggtgacgtcc ggcttgatcg
     2821 ccgcgtcacc gatacgcggg ccacggctgg agaacggggc cagggtctcg tcgcggtcga
     2881 cagcgccgac ggtcagcgcg gcgtccgcgc tacctggcga gccaactgtc tcctccctgg
     2941 gaccgctgtt gcccgcggcg atgacgaaca gcgtgccgtg cttggccgac aacgtgttca
     3001 cggcttcttc gagcgggtcg atgtccggtg tgtctccgcc gccgaggctc aggttgacga
     3061 ccttggcgcc ctgttcgacc gcccactgca tgccgccgat gatccaggag tcgtagccgt
     3121 agccgccgtc ggcgagtacc ttgccgtcaa tgatgttggc gccgtacgcg acacccttgt
     3181 acttgccgtt cgccttggcg ccagtgcccg cgattgtcga cgcgacgtgc gtaccgtgcc
     3241 cgtagcggtc gacggcgtcg ggggagtcgc tgaagttctt ctcggcgacc tcgcgcgtcg
     3301 ccaggtctgg gtgcgtctga tcgacgccgg tgtccagcac ggcgaccttc acgccctcgc
     3361 cggtgaaccc agcgtcccaa gcggcagggg cgccgatctg cgcggtgctg cggtccagcg
     3421 aggctttgcg cttgccgtcg agccagacct tcttcacggt cgcgccggtc agcgactgcc
     3481 acgcggcgcc gcccttggtc gccgtgaccg cggatgcgtt gatcgcggcc aggttcgccg
     3541 ttgtggtggc acccgcgatg ctcgcgcccg gcgcgtggct cacgatcaac ggcagggtgt
     3601 tgttccgttc gccgtcgcgg tagtccgact cggacagcag ggtcacgtcg aacaggcgct
     3661 cgtccacacg cccttgcgcg ataagggaaa cagcgtcctg cgggacgacg tagtggtgac
     3721 cgtcgcgttt gtacgtcgag aatgcgagtt tctcccggcc tttgccggga atgatggcgt
     3781 gcacgctgta cgcgtcctcg accatgacaa ctcggtcgcc cgtgataagt gtgaccgacc
     3841 ggccgttggg ctgagctacc ggcgccgcac tggccacttg tgccgtgctg agcgccaccc
     3901 ccagaacgag agccccgacg cagatacgtc tagcggctcg tctcttggct gaatgcacct
     3961 gaaaaacctc ccgatcggtt ttctgcgcac gccccagaca tcgacggtat ggagtcgatg
     4021 aaccactgtc agtggtcacc gcaagctatc gggaccacca tggggtgaca agtcctcgac
     4081 aggacaatct cgaaagtaaa tttccccagc gagagatcac cgggtgttta cggacgttcg
     4141 ctgaccgtcc catcggggga caccagtacg ccaccttgcg gtgtgccgcc tccgcagtcc
     4201 ggaccagacg gatagcggac tttcgggctg accgtcagcc gtggcgcgcc gatctcggca
     4261 cgggctggat cgatcaaccg cagcgtgacc tcgaccggtc cggcgggcag ttccggcagg
     4321 tcggcaaagg agttcttgcc accggtcggt tccattcgcg caccgcacgc ggtgtccggg
     4381 ccggttggcg tgcacggcag cgcgctggca gcggtcgacg ggtacagctc aaggtctttg
     4441 tcctggcacg aaccgttcca gcatgcggtc agccgggccg agccgacctt cggcgcgtag
     4501 gccgggtcga tgtccagcga gatgcccttc cggatcgccg caccgctgca cggcacgccg
     4561 gcgccctgca gcgtggaccc gcatccggtc aggacggtgc aggcaagggc gagcgcggcg
     4621 gtgagattcc ggttcacgtt tcttggacgt gcgtcaccgg tttttcgttg cacgccttcg
     4681 ctgccaccac cgcaccttcg gcagatgtcc ttcagcccgc aaccattcca cgaacgccca
     4741 cgcgtcatcg cgcatccgtg aaccgtcctt gcggggatgc gccttggcgt actcggtgaa
     4801 cagcgggaca aatctgtctt cgaggtccgc gcacacgtcc ggctcgatca tcgccacgat
     4861 ctgccgccgt ttcgaccgca gtgccttggc ttcgacttcc agtcgtcgcg gatcaaatcc
     4921 cggtggcggt gggccttctg ccagcaaggc atgcagcaat tgtgcttgct gctcggcgag
     4981 acggtctcgt tgcggctgtg tcatagccgt tcccggatcg cctgcagctc ggcggcaagg
     5041 tccgcgtcgg acgggtagtc accgtcgcgc tccagcagga cgcccggcgg cttggtgcgt
     5101 ttcaccaact ccgccaacag gtccagtacc tccggcagca ctgggtgcgt gtgcgtgtcg
     5161 tggtaaacgc cgttgtgttc ctcgccgccc gcgacatgca cgtaagccac acgttccagt
     5221 ggcagttcgt cgaggagctt gactggatcc tggttcaggt tgcgggcatt ggcatacatg
     5281 ttcgcaacgt ccacaagcaa caggcagtcc gtccgctcgg tcagctcgcc gaggaactgc
     5341 gcctcggtca gctcgacgtc cggccactcc agcaaggccg cgatgttctc cagcgcgaac
     5401 ggcacatcca ggttcgcctg cacggttttc acattggcga caagcacgtc caacgcttct
     5461 ctggtccgcg gcaccggcat caggtgcccg gagtccaagc cgcccgcccg tacgaagcag
     5521 acgtggtcgc tcgcgaccgg cgcgtccaac acgtcggcga gcctggccag gtgctcgacc
     5581 cgtttcatgt caacgggttg tgcgccaccg acggacaacg acaccgcgtg cggcagcact
     5641 ggcagaccgc gttccctcag cagcacaacg gattccggta gccggtccgg gttcaggttc
     5701 tccgcgacga cctcgacgaa gtccacgcca ggcagccgtt ccacggtgat gtcgatctcc
     5761 gagcgccagc cgatgcccac tccgagagcg tccattcgct acacccctcc cgaaccgcac
     5821 ccgatgccgc tggaccaagg gctgtccttg tcgatcacct tgcttcgcaa tgccttggcg
     5881 gcgacagggc cagggtagtt cgcgagcccg cccaacgcga ccagagtcgc cgcgtctgtg
     5941 ccttcggtgg tcttgatcac gtacctcccg gctgtggtcc gctttatctc ataaggcatc
     6001 cagcgttgcg gaaccaacgc ggcaatgagc accacgaagg tgacgaccag cagcagtggg
     6061 tcgaacagga ccacgccgag cgcagcggcc acgatcaacg gtgacgctgc cttgagcagg
     6121 tggatgggcg tgaggcggag cagcaatccg cgctgcgcca acgacatctc tgcctgtttg
     6181 atcgcatcat ggtgctgcag cgtgactttc aggcggttga ttgtagtgcc cgcctcgacc
     6241 ctgccgagga tcacccgttc cagttccgtg cgtggcttga cgttgcggcg actgccgaga
     6301 ctgagcacac cctcgcggcc gatccggatc gccttgcgct ccgagagggt cacgatgctg
     6361 gtctcgacca tccgctgcca gcccgcctgg aggaaggcaa cgtcctcaac ggtcgggctg
     6421 aggccggcca acggcacgtc gaccgacctc aaccgggctc gtagcaccag tgtcgcgatg
     6481 gtcgcgatca ccaccacgcc caagtgcagc cagaactctg tcactcagga gcctccgcca
     6541 ccacaaccac cgccgcctcc tcctccgcag ctgctacctc cgccgccacc ggaactatcg
     6601 ccgccaccgc cgccgaagaa gccgtacgtc gcaacgctgg tcccggcgta cgccgagccg
     6661 cggctgcggg atgaccgcac ccgccgcggc tcttgaagaa gccgggagat cgtcacgtcc
     6721 gggtagcccc gcatcccgtg cctggccact gcggtcgctg ccgcttcgac cgcgttgccc
     6781 cgctcatcga gggcctgcct gcccgcgcgg gtcggaccgg ccttgatctc ccgcatcgcg
     6841 aacagagtcg cgatgacggt caggatcagc aatccggtca ggtaacccac cgggaagccg
     6901 aggttgatgc cgttgatcca ccgcgcgatg ccgatcacca ggagcgcgac caacggcagc
     6961 gcggcgacga aaacttggcg gcggctgctg ccgtagtagt acaggccttt gtccgcgagg
     7021 gacgtgctga tggcctcgta ctcgggcagg ttggtcatgg acgccaggtg gtagtgcagc
     7081 ggccgtccct gccgcttggt gatccggttg accaaccgct cctccagcac cgactccggc
     7141 ctggccgtgg tgtcgctgac cggatacagc aacccgttgc gctgcacgcg gatcacgttg
     7201 cgctccacca ggttcgccag cgccgactcg acgacgcgga cccagccgcc cgacaggaag
     7261 gcggtctcgt cgaccgtcag cggctcgtgc gatcgctggg tggacgccga gcggatccgc
     7321 ctgcgcagca gcacagtcac gactcccgcg accagcaggc caccgatgta cagccacagg
     7381 aattccggac cggacaggcc ccaagggttt tccatgaccc tctcccctct tgtgtgtacg
     7441 ggtaggcccg gggacgcgtg tccccgggcc tacccacctc cccctgctac cccttgcagt
     7501 tgccttccgt gccgcagctg atgggcacgc aaccgctcat ccccccggat gtgacacccc
     7561 tccggcccgt cagtgcgtcc cggatcatcc ggtcggggtg cctggtgaac ccacctgccg
     7621 ccaccagctc ggcaggtgcg gtcaccgagg cacgcccgac cgcattcgcc ccctcgaacg
     7681 tcctcgggca gatcgcctgc cggtacatgg cgtaaccgat caccccgctg cagatcagca
     7741 acaccgtcaa ccacccgaca ggcctgtcgc cggcggcccc ctcaagccac cgcacgactc
     7801 cgaccgagaa cacgacgacc accgggacca agctgatcac cttgcggcgc ttggccagct
     7861 cgtcgtccac cagatatccc gcgcccacaa ggcgagcgac cacttcctcg acggcgtcgg
     7921 actccgccag cctgcgcgtg aggatcgaga tcgacctgcg tccgtgcctg ctcacgtcgg
     7981 cgacgaccgt gcgctcgacc gggtcgccac ccccggacct gcccaccagc tgcagataac
     8041 cgtcccggga agcgcgcagc tggccggtgt cgaccagctg cgcgaccgcg gcctcaacca
     8101 ctcgccgcgg acccccggtc aggcatgcca gctcctgtgc cgacagtgcc tgaatgggtg
     8161 cggttgtggt ggccgcaccc gaacgagtga gaatgcgaac agcgaacgcg aacagcaaag
     8221 cgatcgaaaa cccgagcaga taaataccga tgaacgtcgg ctcgggtatt ccccaagtgt
     8281 cttccatgat cttccccctc tctcctagga gagccggaaa tcaagtggag acaccacttt
     8341 cttcgtaccg ggggcacccg gcaagacacc ttgactaaga tttagggttg tgttgggggt
     8401 aacttaggat tgctggtccg ggccgtcgtc cggccgcaac gtcagcgaga tgctgttgat
     8461 gcagtagcgc tggtcagtcg gggtcgggta gccctcaccc tcgaacacgt ggccaaggtg
     8521 gctgtggcac gtcgcacaca gcacttcgac gcggaccatg cccaatgacg cgtcctcgcg
     8581 gagaataaca gcgtcaccgg caagcggtga gaagaacgac ggccacccgc aatgcgagtc
     8641 gaatttcgtc gaactgcgga acagttccgc accgcacgcc cggcacgcgt acacaccgac
     8701 agtcttcgtg tcggtgtatt caccggtgaa ggcacgctcg gtacccgcct tgcggagtac
     8761 cgcgtactcc tcggcggtca gctgctcccg ccactcctgg tcggatttga ccacgcgcgg
     8821 agtgacaccg gtaacgggct tcatggacac ctagcctccg aagctggtca ggatgaacac
     8881 cagtgagtcc cacaccgcga cacccacccc gatcaggatc aacccgatga acagcagggc
     8941 aagcatccgg tagtggccac cgaggcggtt cgccgagtcc gcgaagtccg agatcccgcc
     9001 gaggtatccc tcgacggtgt accccgaccg gctggtctcg atccgttcga gatgggccgc
     9061 gaacgccttc acctcagggt catgaggatc aaggccttca aggtcctcgc gaaaccgctg
     9121 tgacgcgggc tcatcagggg acgcgttcac tgccatatca acaccgtagc cggtcagctt
     9181 gattcccggc tccccaaacc gcgctcgtca gccacatcgc cggaacggac gtggacgaaa
     9241 gaggtgtatc cccattcctc caacctgccc agctgcgtgc cgaacttgcc gcgccgcttg
     9301 atcgttgtga cctggcggcc ctcggcgcgc agccgccgcg ccacggccag tacctccgcc
     9361 ggggtgacat cggcttcgtg cagcacagcg acagcgtccg tacgcggagc gttgtcgagc
     9421 aggttcacga tccgctcgaa accgatagag aacccacagg cggggacgtc cttgccgagt
     9481 gaccggccga tcagcttgtc gtagcggccg ccgccggcca ccgacgcgct cgtgcccggg
     9541 tggctgatct cgaagatctg cccggtgtag taccccatgc cgcgcaccag agtcgggtcg
     9601 aactcccaac ccagctcacg ggttgtggcc agttcggcaa gcgccgtcgt ggtcgtcacg
     9661 agatcctcgg cgacgttctc cgccaggtta ggcacggcgt cggtcagctg gtcggtcagc
     9721 ttggccggat cgaggccctg caacgcggtt atcgccgtct gcacgccgtc gacctgggca
     9781 gcggtgaacc cggcgcgctc ggtgagctcc ttgcgcaccc cgtcccaacc gatcttgtcc
     9841 agcttgtcca gcgtgatgaa gaaggatccc tgtgcctccg gggcaacccc ggcgccctcg
     9901 gccaacgcgg agaggaaccg gcggtcggac aggcggacgg tcgtgccagg caggcccgcg
     9961 gccgcgagag cgtcggtcgt ggcttcgatc agctcggcct cggcgagcac ggactcctcg
    10021 ccgatcaggt cgatgtcgca ctggttgaac tggcggtagc ggtccttctg cggcttctcg
    10081 gcgcgccaca ccgggccgaa ctggaaggaa cggaagggaa ccggcagggc ggcgtggttg
    10141 ttgccgtaga agcgcgtcag cggaaccgtg aggtcaaacc gcagcccgag gtcggccagc
    10201 tcgtcgaggc tgtccggcag ctcggtcagg ccacggcgga ggatcttgta gatcagcttc
    10261 tcgttctcgc cgccctgccc gccggtcagc cgctcgatgt tctcgatggc tggggtctcg
    10321 atgcgctggt agccgtaccg gtggtagacc tcggtgatcc gggccaggac atggtcgcgc
    10381 acggcgactg tcgcgggcag caggtcacga gtgcccctgg cggggctgtt gtccatcttc
    10441 accggtagtc ctcatctcgc ggataggtcc tctaaaagta ccgggcgcac gcgaggtgtt
    10501 ttacgcctag ggttgccgca tggcgtcgaa ggcgatcgag ctgacagtcg gcgaacggac
    10561 cgtgcgcgtg tccaatccgg acagggtgta tttcccggag cgcgggatca ccaagcgcca
    10621 ggtggtcgag tactacgtct cggtggccga gccgttgctg aaagtgttgc gggacaggcc
    10681 gacaaccctg aaacgctacg tcgacggcgt gaccggggag gcgttctacc agaagcgcgt
    10741 acccaagggc gcgccttcct gggtggagac cgcgacgatc aagttcccgt ccggc
//
