LOCUS       NZ_FWXV01000008        24358 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Kibdelosporangium aridum strain DSM 43828, whole genome shotgun
            sequence.
ACCESSION   NZ_FWXV01000008
VERSION     NZ_FWXV01000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kibdelosporangium aridum
  ORGANISM  Kibdelosporangium aridum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Kibdelosporangium.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900176515.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:02:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,283
            CDSs (total)                      :: 11,193
            Genes (coding)                    :: 11,032
            CDSs (with protein)               :: 11,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 3, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 38 of 161
            Pseudo Genes (incomplete)         :: 135 of 161
            Pseudo Genes (internal stop)      :: 6 of 161
            Pseudo Genes (multiple problems)  :: 17 of 161
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:58:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 317471
            Orig. end                         :: 341829
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FWXV01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24358
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24358
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24358
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14358](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14358)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    22..37
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     gene            complement(1426..2175)
                     /locus_tag="B9C43_RS37305"
                     /old_locus_tag="SAMN05661093_07610"
     CDS             complement(1426..2175)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662498.1"
                     /locus_tag="B9C43_RS37305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07610"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_235039074.1"
                     /transl_table=11
                     /translation="MIKTRNLTLGLAGLLLLTSACSNQSNSATTDTTAGAGLSKVLFLG
                     DSIAAGEALPLAAAFQASGVGFQSIASEGGGNVVGPFSDKNWEKLPGQITSAKPAVVIY
                     QLTTYDWGSEQEQQAAYGKLLTTVTGAGAKLVFVTAPPIRPDDFYKPHMAALDRSPNVA
                     RAVAANAPGQANVLDASAVWGATYLQVKDGKADRSADGIHTCPQGAARFTHWLLAELAR
                     LFPGFTPAAAQAWANTGWSADNHFKGC"
     misc_feature    2215..2225
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            2289..2963
                     /locus_tag="B9C43_RS37310"
                     /old_locus_tag="SAMN05661093_07611"
     CDS             2289..2963
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225617.1"
                     /locus_tag="B9C43_RS37310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07611"
                     /product="response regulator transcription factor"
                     /protein_id="WP_084431567.1"
                     /transl_table=11
                     /translation="MAAILLIEDDPLVRRGLQLALGRHGHEVRTADTGEDGLREFRAST
                     PDLVVLDLMLPGIDGLDVCRHIRAAGEVPVIMLTARGDDFDIVGGLEAGADDYVVKPAQ
                     PTVLDARIRAVLRRSTGTSEGVRVHRDLQVDTTALTVSLHGKPVSLTPTELRLLLTLSR
                     APGRVFSRQQLLEEVWEHDYLGDSRLVDNCVQRLRAKIETNPAVPEYVQTVRGFGYRFG
                     PV"
     gene            2960..4366
                     /locus_tag="B9C43_RS37315"
                     /old_locus_tag="SAMN05661093_07612"
     CDS             2960..4366
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662500.1"
                     /locus_tag="B9C43_RS37315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07612"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_084431568.1"
                     /transl_table=11
                     /translation="MTRWFWPRGLRVRLLVAFALVTVLGAAAAAWSSAGSASTALVSSA
                     QQRITETVVGQIRAITPQLTYPPGQDALDRLRAAVVGDTLVTYQDLRSANFTGPDLVTA
                     ELRTAVRTRNRLVTQRITVNGTPWLLVGTPIMITAPDGARTPSGIEVYSVHDLTSVEEE
                     INGLTRSAVSTAALALPLAVLLALLAAGSVLRPVRQLRNTARRLAAGDLNARSAPQGAD
                     ELAELTVTINEMAESVQTSMAAMRRMQADARRFAADVSHELRTPLSTLTAVVEVLATTA
                     DGMEPDARESAQLAITETHRLVRLVEDLMEVSRFDAGTAHLRVEDVDVAGAVRDCLRAR
                     GWLDQVEVSAPNEIVLRLDRRRLDVIVANLVGNALRHGGPPVRVRVSASREQVRIEVTD
                     SGPGLPEHVLPHVFDRFYKADAARARTPGSGLGLAIALENARLHGGDLTASNTAAGGAR
                     FVLSLPREDA"
     gene            4363..4833
                     /locus_tag="B9C43_RS37320"
                     /old_locus_tag="SAMN05661093_07613"
     CDS             4363..4833
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225619.1"
                     /locus_tag="B9C43_RS37320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07613"
                     /product="hypothetical protein"
                     /protein_id="WP_084431570.1"
                     /transl_table=11
                     /translation="MNRLWLAVAALLLAGCGVHPSGVTDAGDAPTGVAPGVTLYFVNAR
                     NELEPDLRPTERLGSISEAMSLLLTGPGNSDLHTEIASNAPRQVVVTTTPEVIQLTVPL
                     AIREVTPRGIDQIVCTALGVHVQSGGSRDTKVQVHFTLTTPESDKLRTCPVR"
     gene            complement(4781..6010)
                     /locus_tag="B9C43_RS37325"
                     /old_locus_tag="SAMN05661093_07614"
     CDS             complement(4781..6010)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225620.1"
                     /locus_tag="B9C43_RS37325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07614"
                     /product="acyltransferase"
                     /protein_id="WP_084431572.1"
                     /transl_table=11
                     /translation="MTQLQPTGIARKAHQPALDGLRGVAILGVLLFHSDYLSGGFLGVD
                     LFFALSGYLITDLLLREIEVTGAVSLVAFWGRRIRRLLPALATMLAVTAVVVWAAGSPE
                     MVRTTLSDGPWVQLNLVNWHLLAQEASYWDRFGEGEARVFEHLWSIAVEEQFYLVWPAL
                     LLAIAWCGRRRVDGRVAVIAALASVASLVLMIALVNSVDPTRVYTGTDTRAFSLLLGAM
                     VATRSARAMLARVVGRRGVVVLTLTVGIGTAWLLVDGVNSVWLFTGGLFAHSLASALLI
                     GLCVQAPQALVAKVLAWQPIRWLGLISYSLYLWHWPVFVLLSPQRGWVQTVAALAMSIA
                     LAALSKYLVEDPIRFRARWAVGRSGLFAFVALMIGLAALWILLPAPAPATIDITELGMS
                     AACPTPGWSG"
     misc_feature    complement(5948..5950)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6136..6849)
                     /locus_tag="B9C43_RS37330"
                     /old_locus_tag="SAMN05661093_07615"
     CDS             complement(6136..6849)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009950998.1"
                     /locus_tag="B9C43_RS37330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07615"
                     /product="flavodoxin family protein"
                     /protein_id="WP_084431574.1"
                     /transl_table=11
                     /translation="MSSRFEGLRALFFNGTLKRSPEPSNTEGLIRVSADLMAREGVEVE
                     VIRTIDHDIAVGVYPDMTEHGWASDEWPALYEKVLAADILVLCGPIWLGDNSSETKKLI
                     ERLYACSHLLNDAGQYAYYGRVGGCLITGNEDGVKHCAMNVLYSLQHLGYTIPPQADAG
                     WIGAIGPGPSYLDAGSGGPDNDFTNRNTTFMTWNLMHLASMLKAHGGIPAHGNQRAAWD
                     RGERFDFINPNPGYR"
     gene            7048..8643
                     /locus_tag="B9C43_RS37335"
                     /old_locus_tag="SAMN05661093_07616"
     CDS             7048..8643
                     /EC_number="1.6.5.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019604.5"
                     /locus_tag="B9C43_RS37335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07616"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_084431576.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2e-49, bitscore:
                     163.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDLVVGAVVGLLCAVPVLAVQGMSIGWYSLYAVVAGVVVALVSG
                     HGRSNAAVVASSGVLVGVLGWLLVVLTLEPLLRGETPTWSATAVLQSYPFLVGDVLHGG
                     LTGLVLAVVPNVHKEQPVREAARIVIVGGGFAGVAAAKRFEQLAARGAPIDVTLISDSN
                     FLLFTPMLAEVASGALEPAHISAPIRSAVAHTRFRNGRVRKFDTGSRTVQLGDDVIPYD
                     HLVLAVGSVPHSFDLPGVSEHAWTLKNLADSTRLRNHVIRQLELADSEPDPVQRRQLLT
                     FVVAGAGFAGTEMIAELFDLVYRTAHYFPGVGLDEPDFLLVHPGDRILPEMSAELADYA
                     LERLRARGIRCRLGVRVAEATADAVRLDDGEWIATNTFVWTAGNRPSPLVGAKAIATDS
                     RLRAAGLENLWAVGDCARIPDPDGTYYPPTAQHALRQGKAVADNIAAVLSGREPAEFRF
                     RTLGLLVALGHRTAAADIRGRRFSGLAAWLLWRGIYLAKLPGLEKRIRVAFDWGLDLVF
                     PRDIVVTSPDEVPR"
     gene            8640..9971
                     /locus_tag="B9C43_RS57815"
                     /old_locus_tag="SAMN05661093_07617"
     CDS             8640..9971
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9C43_RS57815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05661093_07617"
                     /product="hypothetical protein"
                     /protein_id="WP_084431577.1"
                     /transl_table=11
                     /translation="MNAAARGAIAGVAGGLVFGVSMAVYGMLPTVASIVRTDSAVVGFA
                     VHMVFAVIIGAGFGLIVSRQRELVLWGLLYGAFWWFLGPLTLLPLFRGEPVSWDLSSAR
                     ALLPSLIGHLCYGMAVALVYMVLRGDQPSTRPPATALVRGGLAGVIAGMLSHLGWGWLI
                     GLAAGLLYPYLFRDRENTGPALVRGAVYGFLWWVLFGLTAEPLLLNVKLDWARPPVDQL
                     PGYLLLGGLTAVLYTWLGSVARGLFVDDVRMFPVESPGARGFRAVGYGAVAGLVGGALF
                     TVVMVVVGVLPLVASMVGSSEPVVGLIVHLVISQIIGASYAVLFRRQSFDAVSGIGWGL
                     CYGFFWWILGNLTLLPVFTGSPVRWDPAALAAGFPSLAGHLAYGAALGAVYYWLESRTN
                     PWWMTRNAAEQARVQGRRQQSLGSAPALWTLTVFIALTVPVLIP"
     gene            complement(10001..11305)
                     /locus_tag="B9C43_RS37345"
                     /old_locus_tag="SAMN05661093_07618"
     CDS             complement(10001..11305)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="B9C43_RS37345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07618"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_084431579.1"
                     /sec_met_domain="LANC_like (E-value: 6e-53, bitscore:
                     174.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHIVTELADRLVDPARVAVTTDAPGNALRTDNGDLTLWTPVGL
                     SDGHPALALLYAELSASDPGLREHTHAHLRAAIASTAPRPGGGLFGGLAAVAFAAHAAA
                     TESGGYQAMLTQFDQAISRECQALAARDRAKIANGQAIGGWSGYDVPVGITGVGRHLLA
                     RYQLTGSQAVLAALEDVLATLVDIALAGDIDVRGRRMPAWWNHHDTAGIPAEGGGHLNF
                     GMAHGVGGPLALLALAWQAGVAVSRHDEAMLRILSLMRKWQLDDESGPFWPYSVTLDGP
                     SPPGRYREVWCYGAAGIGRALFLAGTALDDASWRETAHDALRGAFTIALTGHNRIRDSG
                     LCHGWAGLLQIASRMAFDTGDRYYTETADELAVRLEKAYDPEAPFGFRYDYPGSVRPLD
                     RPGFLEGAAGIALALHCHATGRPPVTGWDAPLLIS"
     gene            complement(11302..14358)
                     /locus_tag="B9C43_RS37350"
                     /old_locus_tag="SAMN05661093_07619"
     CDS             complement(11302..14358)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="B9C43_RS37350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07619"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_084431581.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.9e-175,
                     bitscore: 579.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.2e-18,
                     bitscore: 61.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.4e-38, bitscore:
                     126.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTSTRFRALDFAIVRLSARSSGDGDYPAPQELDRPEAVNAFLRE
                     VCADPYVREAIEVSSPSLAAALDKISSGALTDPARRRRAALSLNRYLARMTQRPTPFGL
                     MAGVAAAQFDDQPKIRVGTGHRRHVRVDLSWLAEVIRPRETDPAVLCRLRVVRNDLCFL
                     RGDRLVLPLVPEESGVRGPDDRERTVRHTRPVRAALAAAHTPITFPVLLARLGAEFPQA
                     GEEVLTKLVTQLVALEFLVTDLRPPATTEDPIAHVLARGGPAPELAKVRDELDRYAATP
                     VGQGLDALRAVTATMRGIHDQAQLLHVDLGMDADLVLPAAVADELAAAAEVAWRVAPPR
                     LAPADPLAAYRMDFIERYGTGTVVGIKDLLDAERGIGPPAGYLLPPGNRSVSTGRPGES
                     ERDVTLLALAEQAVARDKREVLLDEDTIERLARPGAPGERGSYAEICAQLLADSEDALR
                     RGEFRLVGGGDVNFTRVGALFGRFLPLVPQLRDKVGAVAADLVAEDGVTPAQVVTPPLH
                     PRMANVTQVPRLTSEAMVFGAYAERPSELSLDHLGITADFDRFAVVSLRDGREIAPLVF
                     HSLNPNLAVPNAVRLLIEIGESRTPSWPLWHWGAAADLPYLPRIRHGRTVLSPARWLPD
                     PRLRADLGRGEWSRLFERWRADWSVPRIVYATTAADRRIRLDLDSAAAVELLRADLRKR
                     PALVLREEPAGGEFGSGWARGHAAEVVVPVVPLRPARPRARAAAASRPFVSRSYPPGGE
                     WLYLKVYAHRGRHTELLTHHLPVLVARAQPLSDRWFFLRYADPAHHLRVRFHGDPDALN
                     SELLPIAHRWAAELIEAGLIAELATGTYQPEITRYGGPSAIDAAERAFHADSQCVLEQL
                     ILREQGKLELPMGLLLAANHLELARLLHGDDGWQDWLLATFAKDKHHKAFQQCRREAVR
                     LLDPSDLTALPGGQELLDSWRRRAPLLRDYARALRDADSGEVSSAFASMLHVHHNRLSG
                     ASLDEERDAYAIARGVVQAHQDRERQERR"
     aSDomain        complement(13618..13896)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B9C43_RS37350_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.40E-19"
                     /identifier="RREFam001.1"
                     /label="B9C43_RS37350"
                     /locus_tag="B9C43_RS37350"
                     /protein_end="247"
                     /protein_start="154"
                     /score="61.5"
                     /tool="antismash"
                     /translation="VVRNDLCFLRGDRLVLPLVPEESGVRGPDDRERTVRHTRPVRAAL
                     AAAHTPITFPVLLARLGAEFPQAGEEVLTKLVTQLVALEFLVTDLRPP"
     gene            complement(14504..14680)
                     /locus_tag="B9C43_RS56990"
                     /old_locus_tag="SAMN05661093_07620"
     CDS             complement(14504..14680)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9C43_RS56990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05661093_07620"
                     /product="hypothetical protein"
                     /protein_id="WP_160096951.1"
                     /transl_table=11
                     /translation="MGEFDLDLKIEGVAGAGWAAHLNESGVALAEHPEHDSAALNTCTS
                     PCTSVACTHSGSC"
     CDS_motif       complement(14624..14680)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGEFDLDLKIEGVAGAGWA"
                     /locus_tag="B9C43_RS56990_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14504..14623)
                     /prepeptide="core"
                     /locus_tag="B9C43_RS56990_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-0.50"
                     /molecular_weight="3729.0"
                     /monoisotopic_mass="3726.7"
                     /core_sequence="AHLNESGVALAEHPEHDSAALNTCTSPCTSVACTHSGSC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGEFDLDLKIEGVAGAGWA"
                     /leader_location="[14623:14680](-)"
                     /alternative_weights="3747.0"
                     /alternative_weights="3765.0"
                     /alternative_weights="3783.1"
                     /alternative_weights="3801.1"
                     /alternative_weights="3819.1"
                     /alternative_weights="3837.1"
     misc_feature    complement(14789..14804)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    14858..14869
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    14921..14936
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.49"
                     /tool="antismash"
     gene            complement(15103..15363)
                     /locus_tag="B9C43_RS37355"
                     /old_locus_tag="SAMN05661093_07621"
     CDS             complement(15103..15363)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645616.1"
                     /locus_tag="B9C43_RS37355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07621"
                     /product="hypothetical protein"
                     /protein_id="WP_084431583.1"
                     /transl_table=11
                     /translation="MDPYTPAPDPRGWRRGYLAAWVAIPFTVIQIWAMAIVLTTARFDG
                     PAAVAVPLALSGTMVAVLAGWRWAWRLGRKTSEQRRPALIT"
     misc_feature    complement(15418..15431)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            15581..16597
                     /locus_tag="B9C43_RS37360"
                     /old_locus_tag="SAMN05661093_07622"
     CDS             15581..16597
                     /NRPS_PKS="Domain: PKS_ER (16-334). E-value: 4.1e-55.
                     Score: 179.0. Matches aSDomain:
                     nrpspksdomains_B9C43_RS37360_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667094.1"
                     /locus_tag="B9C43_RS37360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07622"
                     /product="medium chain dehydrogenase/reductase family
                     protein"
                     /protein_id="WP_143446871.1"
                     /sec_met_domain="ADH_N (E-value: 1.8e-11, bitscore: 38.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 7.2e-15, bitscore:
                     49.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTTQMRAVNRDAANCLQVRETELPAPPAGQVRVRVEAAGVSYGD
                     LLFQRGVVPGGPKTPFIPGCDLVGVVDAVGSGVTDLEPGQRVCALVVSGGYADGMNLPA
                     ERVVPVPDGMSAVDAAAVSLNYFIAHQMLHRVGKVTSGSRILVHGASGGVGLAFLQLAE
                     HIGGVTVFGTASAANLDLLRRHGAIAIDYRADDFANVIRDNGGKVDVAYDPIGGTHFIR
                     SYSVLRRGGRLVAYGQNDALRNGKPSLRIGAIGFLAGIAAPKLIPDGRTTGFYNALALE
                     KTQPHAYREDLTEVLSLAAANKIAVRELITVPLRDAEEALQRVEAGVAGKIVLDCTA"
     aSDomain        15629..16582
                     /ASF="ER domain putatively catalyzing 2R-configuration
                     product formation"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9C43_RS37360_PKS_ER.1"
                     /evalue="4.10E-55"
                     /label="B9C43_RS37360_PKS_ER.1"
                     /locus_tag="B9C43_RS37360"
                     /protein_end="334"
                     /protein_start="16"
                     /score="179.0"
                     /tool="antismash"
                     /translation="LQVRETELPAPPAGQVRVRVEAAGVSYGDLLFQRGVVPGGPKTPF
                     IPGCDLVGVVDAVGSGVTDLEPGQRVCALVVSGGYADGMNLPAERVVPVPDGMSAVDAA
                     AVSLNYFIAHQMLHRVGKVTSGSRILVHGASGGVGLAFLQLAEHIGGVTVFGTASAANL
                     DLLRRHGAIAIDYRADDFANVIRDNGGKVDVAYDPIGGTHFIRSYSVLRRGGRLVAYGQ
                     NDALRNGKPSLRIGAIGFLAGIAAPKLIPDGRTTGFYNALALEKTQPHAYREDLTEVLS
                     LAAANKIAVRELITVPLRDAEEALQRVEAGVAGKIVL"
     CDS_motif       16004..16066
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B9C43_RS37360_0001"
                     /evalue="5.00E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="B9C43_RS37360"
                     /protein_end="162"
                     /protein_start="141"
                     /score="25.3"
                     /tool="antismash"
                     /translation="GSRILVHGASGGVGLAFLQLA"
     misc_feature    16627..16641
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    16758..16770
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.63"
                     /tool="antismash"
     gene            16791..17036
                     /locus_tag="B9C43_RS37365"
                     /old_locus_tag="SAMN05661093_07623"
     CDS             16791..17036
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9C43_RS37365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05661093_07623"
                     /product="hypothetical protein"
                     /protein_id="WP_084431585.1"
                     /transl_table=11
                     /translation="MSWSVSGGVALYSWQAGCVVAALSLGVDVVRLVAEWRRDRVVLDL
                     VERAPCGTVVNIYPAELLQVWVGSVERQVRDAPPDQ"
     gene            17017..17625
                     /locus_tag="B9C43_RS37370"
                     /old_locus_tag="SAMN05661093_07624"
     CDS             17017..17625
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="B9C43_RS37370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07624"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_084431587.1"
                     /transl_table=11
                     /translation="MPHRISEWDAREVGDFYRQEAKALFRYGYRLMQGNRAAAEDIVQE
                     TFQEAAKRWTMLRALEDSRRRAWLFTVARNKVADRWRIDLREAPVLDVLSPADKMCDGV
                     DVHQRVIDSIVLDKCWKAIKQMPSRQHQVAWLRWHDGCDTAQIGKLLGINSSTVRVHLR
                     NARTALKSAVGPEVRFLDEAADRNQEDADCRDPIGGAEA"
     misc_feature    17107..17109
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17772..18359
                     /locus_tag="B9C43_RS37375"
                     /old_locus_tag="SAMN05661093_07625"
     CDS             17772..18359
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9C43_RS37375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05661093_07625"
                     /product="hypothetical protein"
                     /protein_id="WP_143446873.1"
                     /transl_table=11
                     /translation="MPLADIYRRLGDAVERDIDEFDVDRGAERLAAWMQAPADAEPVPD
                     LSATALSSRAIGVKAVDSQDPLAVDNPIRAKAIIVHLLSANTPLPADSGPYPFSTAVRN
                     QRLLEIEIWEQTGPVESSDVEHNIQIGRGVLRLPPGLPAHSSIEITFSLSEAGTLGVHA
                     VEPNSGAQGRFELQIGETVAAVRADIVGVELK"
     gene            complement(18391..20418)
                     /locus_tag="B9C43_RS37380"
                     /old_locus_tag="SAMN05661093_07626"
     CDS             complement(18391..20418)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020500749.1"
                     /locus_tag="B9C43_RS37380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07626"
                     /product="AAA family ATPase"
                     /protein_id="WP_084431591.1"
                     /transl_table=11
                     /translation="MHSVEPEIRAERDYMDVCRAQLARMREEVSTMLATGAGEGEAVGD
                     KYFNHVLRQFRIQVVEELSDVEGAPLFFGRLGYPNSDFVYVGRRGVRDDDGEPMVIDWR
                     APLARAFYEASRQDPMGVKVRRRYGFDHEGVVTAFEDEPIDRQVESSRLLAAEIERPRK
                     GPMRDIVATIQPEQMSLVRAPIDRTVCIQGAPGTGKTAVGLHRLAYLLYTEGQRLRKGG
                     GVAVIGPNHSFLSYIRNVLPALGEVAVSQTTIDELIGEGIAVERVDDPQAARVKGDARM
                     AEVIRRHLWSRIRPLDETVEIKHQHRTWRLSTEDLAEQIDDVLGREVDYGAGRELLAQR
                     LAHLVLRQMEQAGNASATLHQLRRHRVINRAVGKMWPAIDPARVVFDLLTDQAHLARAA
                     DSVLSVDEQRALLFTPRPRSVRAMRWSSLDLALRDEVAALVDRPGKLGHVVIDEAQDLS
                     PMQIRAISRRMAGSCTVLGDLAQATSPSAVQGWTEVLTHLDRPGGHIEELTRGYRVPAQ
                     VIDFAARLLPHIAPELGSPASFRQSDDALRIVETTPDEKIAATITTCASALAREGSVGL
                     IAADDDIAELHRALSANGLQHTVLGVDGTNLDRLTLAPVTLSKGLEFDTVVVVEPASII
                     QAEQRGLQRLYVALTRAVSTLHVIHTGRLPEPLAQEPAMT"
     gene            20520..21164
                     /locus_tag="B9C43_RS37385"
                     /old_locus_tag="SAMN05661093_07627"
     CDS             20520..21164
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006236470.1"
                     /locus_tag="B9C43_RS37385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07627"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_084431593.1"
                     /transl_table=11
                     /translation="MEELGLRERKKRRTRDAIAEAALALFQESGFDNVTVADVAAAAEV
                     SKPTLFAYFPTKEDLVLHPFLDTTSPAEVVRNNSGVPALTALRQSFLDRLANRDPLTGL
                     NDSPSTITFHDLLYSTPTLMARLAFYMIDQEKELVAELRAAVPDAFTARVLAAQVFGTQ
                     RILSTHNAQEIRNGRTADTVYPAAVARTEAAYTFLESGLAALGASTTTARN"
     misc_feature    21330..21344
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.6"
                     /tool="antismash"
     misc_feature    21622..21634
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.01"
                     /tool="antismash"
     gene            21747..23162
                     /locus_tag="B9C43_RS37390"
                     /old_locus_tag="SAMN05661093_07628"
     CDS             21747..23162
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="B9C43_RS37390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07628"
                     /product="ATP-binding protein"
                     /protein_id="WP_084431595.1"
                     /transl_table=11
                     /translation="MVNNHYLNTLLQNSRLARRYRPVVEKVRATYQREGLEGLVRQGRR
                     VTARLLMPKDPAPGSAGARGAAHTAIDPAVVNDILSNLAIRDWRIVGRLLALFDEMHRQ
                     NPDPRVTQMLFQLDELVTQLRHDHRKKLVLAGRRPPGGQPVAQPMLAVIRGGMSSAPGY
                     ARVRIRDLVPLAVVGDAAKDVSGILTELMTNALHFSPPESPVTVHARMADGGAVLLRVE
                     DEGIGIDQAELDRLNGELLRPPVRSLLDLRDRQILQHLGLVTATILAKPHGIGLSLARR
                     DPAGVVASVLLPPDLLCDPAMAEAETSAARAEAETKPAGRPQIALTSDHAEREHETTPL
                     GLPKRTTRPSPRVGTTPEDDATEPGSQGRHARTTDLPEDARTTAGGLPVRRPGRVREFS
                     AADTDPGLAEREPVEYTELDPAQLRRRAAAMTRVRHAAADDPSDKPARPTPYPKAKPDT
                     NPLFTSSEDRNDA"
     misc_feature    23013..23015
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            23152..23607
                     /locus_tag="B9C43_RS37395"
                     /old_locus_tag="SAMN05661093_07629"
     CDS             23152..23607
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015232.5"
                     /locus_tag="B9C43_RS37395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07629"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_033392965.1"
                     /transl_table=11
                     /translation="MTPNAAQIPDALREEFGWLADNFVSDVPGVVHVLVVSADGLKVAK
                     SKGLHDDAADQFSSLVAMMLSIAKASAGLFGRGGFQYSDIVMGDSFIVFQQISEHSGVA
                     VLASEHDGGQLETVCFELAKFVNQSRRVLNPGMRRQSHTTATPTGQG"
     gene            23627..24019
                     /locus_tag="B9C43_RS37400"
                     /old_locus_tag="SAMN05661093_07630"
     CDS             23627..24019
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159021.1"
                     /locus_tag="B9C43_RS37400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_07630"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_033392966.1"
                     /transl_table=11
                     /translation="MDTTESPEGEWVRPFAVTGGRAIIEQDLLLETIISGSNGRGDDDF
                     AASLDPETRAVYHHVSRTSLSLAELSAQLRLPLGVVRVLVDDLSRAGRVRVHPNAQGRE
                     RDPQVYLRVINGLKRKLEEDRASHAI"
     misc_feature    24031..24045
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.93"
                     /tool="antismash"
ORIGIN
        1 tgggcggtcg tcacaacgct ggtcacgatc gcgtttctgg tgctgctcgg gaccgccgtt
       61 ccgggagtgt ggttcgaggt tctctttctg gtgtggtggg ctgcgctcgt cgcgcatggg
      121 tggtacctcg cgcgtatccc cgcccgcctg ccatctgtgc ggtggcccag gacggttgcc
      181 ttgctcatcg cggttccggt gctggtgggt atcgggtaca tgcggttcga cgccgccagc
      241 atcgaggaca ggatcaccga ggcacgcgac agcggagact gcgggaaagc tcagtccgct
      301 ttggacatga tctggttcgg tcatcatgtc gtggacggcc cgatgacggt tcgcggtgag
      361 cggaccgccc aagcgtgcgc ccgcttggca gataccaagg gagcactcga agtcgcggca
      421 tcgaaacgtg atacccaagg cttgcgatcg agttacgacg aactcggtgc ggtgctcacc
      481 gacctgcccg gccacgacag gatggtcagc actgtcctcg acggcttcct cgacagcctg
      541 tccggccgcg aaccgtgcga cgtcgccgaa ctcgccgact ggctgcggca acgccctgcg
      601 agcaacaacc tgctcgaccg gtccgccgac gtcctgccga agatcgcacc ggccgcgctc
      661 gtggggtgcg gggacaaacg ggcggaagct cgcgactggg ccgccgcaaa ggcgcgttac
      721 cagcagatgt tggaccagta tcctggccac gagctcaccg ccaaggccca ggagggcgtc
      781 aagcaagcca cgctggggct cgagctacag aacctcgcca ggctgggcaa gggctactgc
      841 aagacaccag tggtctatag cggcgcggcc ccatacgcga agggagccac gaaccgcgcg
      901 gtcgtctacc acgacgacga tttcgacgac atgtacatca agaagctgcc cgccgagtgg
      961 caagcagaca acagccaggc cgtgatggtc gtctgcatcg gcgagcggga ggcgggcgca
     1021 ccggtcagga cgtgcccata ccgggacagg tcggacggcc gggtgcggaa cgtgacgttc
     1081 agcaagatgg catatccggt caaggcctac gagctgcgga ccggcaacct cgtggccgac
     1141 accagggtgg agatcgccgg tgcggcctgt ccgccgacgg tcaccagctt tggtgacaac
     1201 gacccattgc ggatggtcgt tgaaccgtcc gactcggata ttcgggctgc gttcgctcca
     1261 gtgttcacgc cgtaacggga ggcgtcaggt gggattccgg cgccacggcg aagtaagccg
     1321 tggcgccgga cgatcaagcc acctcatctt tcggtggtgg tgatgccagg tgacgtgagt
     1381 gcatccgtcg acctcggtgg gcacggtgtg ggccttggca gcgggtcagc agcccttgaa
     1441 gtggttgtcg gcggaccagc cggtattggc ccaagcctgc gcggccgcgg gggtgaagcc
     1501 ggggaacagt ctcgccagtt cggcaagcaa ccagtgggtg aagcgagcgg cgccttgtgg
     1561 gcaggtgtgg atgccgtcgg cgctgcggtc ggccttgccg tccttgacct gcaggtaggt
     1621 ggcgccccac accgcgctgg cgtcgagcac gttcgcctgg cccggggcgt tcgccgcgac
     1681 ggctcgggcg acgttggggg agcggtccag ggcggccatg tgtggtttgt agaagtcgtc
     1741 aggcctgatc ggcggcgcgg tgacgaagac cagtttcgca ccggccccgg tcactgtggt
     1801 cagcagcttg ccataggcgg cctgctgctc ctgctcactg ccccagtcgt aggtggtgag
     1861 ctggtagatg accacagccg gtttggctga ggtgatctgc cctggcagtt tctcccagtt
     1921 cttgtcggag aaggggccga ccacgttccc gccaccctcg gaggcgatgg actggaaccc
     1981 cacgccgctt gcctggaacg cggcggcaag gggcagcgcc tcgcctgccg cgatggagtc
     2041 gccgaggaac agaactttgg acagtcccgc tccggcggtc gtgtcggtgg tcgcggagtt
     2101 ggactggttg gaacaggcac tcgtcagcag gagcaacccg gccaggccca gcgtgagatt
     2161 tcgtgtcttg atcatgtctt cgacggtgcc gtcgccgtgt cgcggcgtct ccgctgccat
     2221 gtcgcggttg tgtcgcaggc atccaccacg accggcggcc gggccctgga tttgtccata
     2281 ctcgacgggt ggcggcgatt ttgctcatcg aggacgaccc ccttgtccga cgtggtctcc
     2341 agctggcgct gggcagacac ggtcacgaag tccgcacggc ggacaccggc gaggacgggc
     2401 tgcgagagtt ccgagcgtcc acaccggact tggttgtgct cgacctgatg ctgccgggca
     2461 tcgacgggct cgacgtgtgc cgccacatcc gggcggcagg cgaagtaccg gtgatcatgc
     2521 tgaccgcgcg tggcgacgat ttcgacatcg tcggcgggct cgaggcggga gcggacgatt
     2581 acgtggtcaa gcccgcgcaa cccactgtgc tcgacgcgcg tattcgcgcg gtgctgcgtc
     2641 gcagcacggg gacatccgag ggtgtgcgag tacaccgtga tttgcaggtc gacaccacgg
     2701 cgttgacagt ctcgttgcac ggcaagccgg tgtccttgac gccgaccgag ctgcggctgc
     2761 tgctgacgct gtcccgggct cctggccggg tgttcagccg gcagcaactg ctggaggagg
     2821 tatgggagca cgattacctc ggtgactccc ggttggtcga caactgcgtg cagcggctgc
     2881 gggcgaagat cgagaccaac ccggcggtac cggagtacgt gcagaccgta cgagggttcg
     2941 gctaccggtt cggaccggta tgaccagatg gttctggccg cgggggctcc gcgtccggtt
     3001 gctggtcgct ttcgcgctgg tgaccgtgct cggcgccgcc gcagcggcct ggtcgagtgc
     3061 cggatcggcg agcaccgcac tggtctcctc ggcccagcaa cggatcactg agaccgtcgt
     3121 cggccagatc cgtgcgatca cccctcagct gacctatccg ccgggccagg acgcgctcga
     3181 ccggctgcgc gcggccgtcg tcggggacac gctggtgacg tatcaggacc tgaggtctgc
     3241 caatttcact ggccccgatc tggtcaccgc tgaactgcgc accgctgtgc gcacccggaa
     3301 ccggcttgtg acgcaacgga tcaccgtcaa cggtacgcct tggctcctgg ttggcacgcc
     3361 gatcatgatc accgcgccgg acggcgcgcg tacgccgtcc ggcatcgagg tgtactccgt
     3421 gcacgacctc accagtgtcg aggaagagat caacggcctc accaggtccg ccgtcagcac
     3481 tgccgcattg gcgttgccgc tggctgtact gctggcgctg ttggctgcgg gcagcgtgct
     3541 gcgcccggtg cgccagcttc gcaacaccgc gcgtcgattg gccgcgggtg acctcaacgc
     3601 gcgctcggca cctcagggcg ccgacgagtt ggccgaactg accgtcacca tcaacgagat
     3661 ggctgagtcg gtgcagacct cgatggcggc gatgcggcgg atgcaagccg acgccaggag
     3721 attcgccgcc gacgtctcgc acgaattgcg caccccgctg agcaccctca cggcagtcgt
     3781 ggaggtactg gcgaccacgg ctgacgggat ggagccggac gcccgggagt ccgcgcagtt
     3841 ggcgatcacc gagacccacc ggctggtccg gctcgtcgag gacttgatgg aggtgtcccg
     3901 gttcgacgcg ggcacggctc acctccgggt cgaggacgtg gacgtggccg gcgcggtgcg
     3961 ggactgcctg cgcgcccgag gctggctgga ccaggtggaa gtgtcggcac caaacgagat
     4021 cgtgctgcgg ctggaccggc ggcggctgga cgtcatcgtg gccaacctgg tcggcaacgc
     4081 gctgcggcac ggtggaccgc cggtccgcgt gcgcgtctcg gcgtcacgcg agcaggtgcg
     4141 gatcgaggtc acggacagtg gacctggcct gcctgaacac gttttgccgc acgtgttcga
     4201 ccgcttctac aaagccgatg ccgctcgtgc ccgcacgcca ggcagtgggc tcgggttggc
     4261 gatcgcattg gagaacgcgc gcttgcatgg cggtgatctc accgcgagca acacagctgc
     4321 gggcggggca cggttcgtgc tgtccctgcc gagggaggac gcgtgaatcg gttgtggctg
     4381 gcagtagccg ctttgttgct cgcgggctgt ggagtccatc cttctggtgt gaccgatgcc
     4441 ggtgacgccc cgacgggcgt cgcgcctggc gtgactttgt acttcgtcaa cgcgcgcaac
     4501 gaactcgagc cggatctgcg gccaaccgag cgcttgggct cgatctccga ggcgatgtcg
     4561 ttgctcctga ctgggcctgg caactcggac ctgcacacag agatcgcgtc aaacgcgcca
     4621 aggcaggtcg tggtgaccac cacgccggag gtgatccaac tgactgtgcc attggcgatt
     4681 cgcgaagtga ccccgcgggg catcgaccag atcgtgtgta ccgcgcttgg tgttcacgtg
     4741 cagagcgggg gatcgaggga caccaaggtg caagtccact tcaccctgac caccccggag
     4801 tcggacaagc tgcggacatg cccagttcgg tgatgtcgat ggtggccgga gccggggcag
     4861 gcagcagaat ccacagcgcg gccagtccga tcatcagcgc cacgaacgcg aacaacccgc
     4921 ttcgtccaac ggcccacctg gcgcgaaacc gaatcgggtc ttctacgagg tacttcgaca
     4981 acgccgccaa agcaatcgac atggccaacg ctgccaccgt ctgcacccaa ccgcgttgcg
     5041 gcgacagcaa cacgaacacc ggccagtgcc acaggtacaa gctgtaggag atcaacccca
     5101 accaccggat cggttgccaa gcaaggactt tggcgaccaa cgcctgcggt gcctgtacgc
     5161 acagcccgat cagcagtgcc gaggccagcg agtgcgcgaa gagcccgccg gtgaacaacc
     5221 acaccgagtt gaccccgtcg accagcaacc acgccgtgcc gatgccgacc gtcaaggtca
     5281 acacgacaac cccccgccgg ccgaccacac gggccagcat ggcgcgcgcc gatcgcgtgg
     5341 cgaccattgc tcccaacaac aaggagaacg ctcgagtgtc agtgccggtg tagacgcggg
     5401 tcgggtcgac ggaattcacg agggcgatca tcaacaccag cgaggccaca gaggccaggg
     5461 cagcgatgac cgcgacccgg ccgtccaccc gtcgtcggcc acaccacgcg atggcgagca
     5521 ggagcgccgg ccagaccagg tagaactgct cctccaccgc gatgctccac aggtgttcga
     5581 acaccctggc ttcgccttcg ccgaacctgt cccaatagct ggcctcctgg gcgagcaggt
     5641 gccagttgac caggttcaac tgcacccacg ggccgtctga gagagtcgtg cgcaccatct
     5701 ccggcgaccc cgccgcccag accaccacgg cggtaacggc gagcatcgtc gccagcgcgg
     5761 gcagcagccg gcggatccgc ctgccccaga aggcaaccag tgacaccgcc ccggtcacct
     5821 cgatctcgcg cagcagcaga tcggtgatga ggtagccgga caaagcgaag aacaggtcca
     5881 cgccaaggaa accaccggac aggtagtccg agtggaacag aagcactccg aggatcgcga
     5941 cacctcgtaa cccgtccaac gcgggctgat gcgccttgcg agcgattccg gtcggctgga
     6001 gctgtgtcat ggggccgact ctgcagcctc cgtgtcgacg tgacgtccct gtcaagtcgc
     6061 agtcttgtcg ttgtcggtag gtgcggcgct ccgcaccaag cctggcttag ctcatccagg
     6121 tggagcgggc ctctttcagc ggtatccggg attggggttg atgaagtcga accgctcacc
     6181 ccggtcccag gccgcccgct ggttgccgtg cgccgggatt ccgccatggg ccttcagcat
     6241 cgaagccagg tgcatgaggt tccacgtcat gaacgtggtg ttgcggttgg tgaagtcgtt
     6301 gtccggtcca ccggacccgg catccaggta ggacggtcca ggtccgatcg cgccgatcca
     6361 ccccgcgtcg gcctgcggcg gaatggtgta gcccaggtgc tgaaggctgt acagcacatt
     6421 catcgcgcag tgcttcacgc cgtcctcgtt gccggtgatc aggcagccgc cgacccggcc
     6481 gtagtaggcg tactggcctg cgtcattgag caggtgcgag cacgcgtaca accgctcgat
     6541 cagcttcttg gtctccgacg agttgtcacc aagccagatc ggtccacaca ggaccaggat
     6601 atcggcggcc aacacctttt cgtacaacgc gggccattcg tcactggccc atccgtgctc
     6661 ggtcatgtcc gggtacacgc cgaccgcgat gtcgtggtcg atggtccgga tcacctcgac
     6721 ctcgacgcct tcccgcgcca tcaggtccgc gctcacccgg atgagaccct ccgtgttgct
     6781 gggctcaggc gaccgcttca acgtcccgtt gaagaacagg gcacgcaacc cctcgaaccg
     6841 agaactcact ggtcactcct attgcgacgg ttggtcgcct gccgagacgc ctgtgccagg
     6901 catggtccga ccgactctag gcatcgtcca gcgccctgac cattaaccac tgattacgct
     6961 acgccgtgag tgttctgtaa ggactttccc gagcggatcg tgtcaggctt tcttctgttg
     7021 accggtgtga cgggagggtg ctggctcatg cgtgacctgg tggtcggcgc ggtcgttggg
     7081 ttgctttgtg ccgtaccggt gttggctgta caggggatgt caatcgggtg gtacagcctt
     7141 tatgcagttg tggccggtgt cgtcgtggcg ctggtgagcg ggcacgggcg gtccaacgcg
     7201 gcggtcgtcg cctccagcgg tgtgctggtg ggtgtgctcg gctggttgct ggtcgtgctg
     7261 acgctggagc cgttgctgcg gggtgaaaca ccgacctggt cggctacggc cgtactgcag
     7321 tcctatccat ttctggtcgg tgacgtgttg cacggcgggc tgaccgggct ggtgctggcc
     7381 gtcgtgccga acgtccacaa agaacaaccc gtgcgggaag cggccaggat cgtgatcgtg
     7441 ggtggcggat tcgctggtgt ggctgcggca aagcgcttcg agcagctcgc cgcccgcggt
     7501 gcgccgatcg atgtgacgct gatcagcgac tcgaacttcc tgctgttcac gccgatgctc
     7561 gccgaggtgg cgtccggagc gttggaaccg gcacacatca gtgcaccgat ccggtcggcc
     7621 gtcgcgcaca ctcgttttcg aaacggacgt gtgcggaaat tcgacaccgg gtcccgaact
     7681 gttcagcttg gtgacgacgt gatcccgtac gaccacttgg tcctcgcggt cggttctgtg
     7741 ccgcattcgt tcgatctgcc tggcgtgtcg gagcacgctt ggacattgaa gaacctcgcc
     7801 gactcgactc ggttgcgcaa tcacgtgatc aggcagctgg aactggccga cagcgaaccc
     7861 gatcccgtgc agcgcaggca gttgctgacg ttcgtggtcg ccggtgccgg gttcgcgggc
     7921 acggagatga tcgcggaact gttcgacctg gtgtaccgga ccgcgcacta cttcccgggg
     7981 gtcggcctcg acgagccgga tttcctgctc gtgcaccccg gcgaccggat tctgcccgag
     8041 atgtcggcgg aactggccga ctacgccttg gagaggctgc gcgcacgagg aatccgctgt
     8101 cggctcggtg tacgcgtcgc cgaggcgacc gccgatgctg tcaggctgga cgacggcgag
     8161 tggatcgcca cgaacacctt cgtgtggacc gcgggcaacc gcccgagtcc tctggtaggc
     8221 gccaaggcga tagcgacgga ctcgcgactg cgcgctgccg gccttgaaaa tctctgggct
     8281 gtgggtgact gtgcccggat tcccgacccg gatggcacgt actacccgcc gaccgcacag
     8341 cacgcactgc ggcaaggcaa ggcggtcgcc gacaacatcg cagcagtcct cagtggacgc
     8401 gagcctgcgg agttccgatt ccggactctc ggcctgctcg tcgcactcgg acatcgaacg
     8461 gcggcggcgg acatccgtgg ccgccggttc tcaggcttgg ccgcatggct gctgtggcgc
     8521 gggatctacc tggcgaagct gccagggctg gagaaacgga tcagagtggc gttcgactgg
     8581 ggactggacc tggttttccc tcgcgacatc gtagtcacga gcccggatga ggtgccccga
     8641 tgaacgcggc ggcgcggggt gccatcgcgg gcgtcgctgg cggactggtg ttcggcgtct
     8701 ccatggcggt gtacggcatg ctgccgacag tcgcctcgat cgtgcgaacc gactctgccg
     8761 tcgtgggatt cgcggtgcac atggtgttcg cggtgatcat cggcgccggg ttcgggctga
     8821 tcgtgtcccg gcaacgagag cttgtcctct gggggctgct gtacggggcc ttctggtggt
     8881 tcctcggccc gctgacgttg ctgccgctgt tccgcggcga acctgtgagc tgggatctct
     8941 cctcggcgcg ggccttgctg cccagcctga tcggccacct ctgctacggc atggccgtgg
     9001 cacttgtcta catggtcctg cgaggtgacc aaccctcaac tcgaccgcct gccaccgcac
     9061 tggtccgtgg tggcctcgca ggtgtgatcg cgggaatgct cagtcacctt ggttggggct
     9121 ggttgatagg actggccgcc gggctgctct acccgtacct gttccgcgat cgggagaaca
     9181 ccgggcctgc cttggtccgc ggcgcggttt acgggttcct ctggtgggtc ctgttcggac
     9241 tgaccgccga acccttgctg ctcaacgtga aactggactg ggcaaggccg ccggtcgacc
     9301 agttgccggg ctacctcctg ctgggcgggc tgaccgcggt gctctacacg tggctgggtt
     9361 cggtggcacg tgggctcttc gtcgacgacg tgcgcatgtt cccggtcgaa tcgccaggag
     9421 cccgggggtt ccgcgcggtt ggctacggcg ccgtggcagg cttggtgggc ggtgccctgt
     9481 tcaccgttgt catggttgtg gtgggcgtac tgccgttggt cgcgagcatg gtcggatcgt
     9541 ccgagccggt cgtcggcctg atcgtgcacc tggtgatctc gcagatcatc ggggcgtcct
     9601 acgcggtgtt gttccggcgc cagagcttcg acgcggtctc cggcatcggg tggggcctgt
     9661 gttacgggtt cttctggtgg atcctgggca acctcacatt gctgcccgtc ttcaccggaa
     9721 gcccggtccg ctgggatccg gccgcactgg ccgcgggttt cccgtcactg gccgggcacc
     9781 tggcgtacgg agcagcactc ggtgcggtct actactggct ggaaagccgt acgaacccct
     9841 ggtggatgac gcgcaacgca gcggaacagg cccgagtgca aggccgtaga cagcagtcac
     9901 tgggatcggc gccagccctg tggacgttga ccgttttcat cgccctcacc gtgcctgtac
     9961 tgatcccgtg acgccaagga tcagcgagac ccggtaaccg tcagctgatc agcagcggtg
    10021 cgtcccagcc ggtgaccggt ggcctgccgg tggcgtggca gtgcagggcg agcgcgatgc
    10081 ccgccgcgcc ttccaggaaa ccggggcggt cgaggggcct gaccgagccg gggtagtcgt
    10141 accggaagcc gaacggtgcc tccgggtcgt aggccttctc aagccgcaca gcgagttcgt
    10201 ccgcggtttc ggtgtagtac cggtccccgg tgtcgaacgc catccgcgag gcgatctgca
    10261 gcaagcctgc ccagccgtgg cacagcccgg agtcccggat ccggttgtgt ccagtgaggg
    10321 cgatggtgaa cgcgcctctc aacgcgtcgt gtgcggtttc gcgccacgac gcgtcgtcca
    10381 gcgcggtccc ggccaggaac agtgcgcgtc cgataccggc ggcgccgtag caccacacct
    10441 cgcggtacct gcccggggga gagggcccgt ccagggtgac cgaatacggc cagaacgggc
    10501 ctgattcgtc gtcgagttgc cacttccgca tcaacgacag gatgcgcagc atggcctcgt
    10561 cgtgccggga cactgccacc ccggcctgcc aggcgagcgc cagcagtgcc agcggaccac
    10621 ccacgccgtg tgccatcccg aagttgaggt gtccgccccc ttcggccggg attcccgccg
    10681 tgtcgtggtg gttccaccac gccggcatgc gccgtccccg tacgtcgatg tcgccggcga
    10741 gcgcgatgtc caccagtgtt gccagcacat cctccagggc ggccagcacc gcctggctcc
    10801 ccgtcaactg gtagcgggcc agcaggtgcc tgccgacacc ggtgatgccc acgggcacgt
    10861 cgtaacccga ccacccgccg atcgcctggc cgttggcgat cttcgcacgg tcacgggcgg
    10921 cgagtgcctg gcattcccgg ctgatcgcct ggtcgaactg cgtgagcatc gcctggtagc
    10981 caccggactc cgttgctgcc gcatgtgccg cgaacgccac tgccgcaagg ccgccgaaca
    11041 gaccgccgcc cggtcgtggg gcggtcgagg cgatcgcggc ccgcagatgg gcgtgggtgt
    11101 gctcacgcag cccgggatca ctcgcgctga gctcggcgta cagcagtgcc agcgcgggat
    11161 gaccgtctga caatcccacc ggggtccaca gcgtgaggtc gccgttgtcc gtccgcaacg
    11221 cgttgccagg agcgtctgtc gtcaccgcca cccgggccgg gtcgacgagc cggtcggcca
    11281 gttcggtcac gatgtgcgtg gtcatcggcg ttcctgtcgt tcgcggtcct ggtgggcctg
    11341 cacgacaccg cgggcgatgg cgtaggcgtc acgttcctcg tcgaggctgg cgccgctcag
    11401 gcggttgtgg tgcacgtgaa gcatcgaggc gaacgcgctc gacacctcgc cgctgtcggc
    11461 gtcgcgcagc gctcgcgcgt agtcccgtag cagcggagcc cgacgtcgcc agctgtccag
    11521 cagttcctgg ccgcccggca gtgcggtgag atcactggga tcgagcagcc ggacggcctc
    11581 gcgccggcac tgctggaacg ccttgtggtg cttgtctttc gcgaaggtgg cgagcagcca
    11641 gtcctgccac ccgtcgtcgc cgtgcagcag ccgcgccagt tcgaggtggt tggcggcgag
    11701 cagaagaccc atcggcagct ccagttttcc ttgctcgcgc aggatgagct gctccagtac
    11761 gcactgcgag tccgcgtgga acgcgcgttc ggcggcgtcg atcgcactcg gcccgccgta
    11821 tcgggtgatc tccggctggt aggtgccggt cgccagctcc gcgatcagtc cggcctcgat
    11881 cagctcggcc gcccatcggt gcgcgatggg cagcagttcg ctgttgagcg cgtccgggtc
    11941 accgtggaac cggacgcgca gatgatgagc cgggtcggcg tagcgcagga agaaccaccg
    12001 gtcgctgagc ggctgtgccc gcgccaccag tacgggtagg tggtgggtga gcagctcggt
    12061 gtgtctgcca cggtgggcgt acaccttgag gtacagccat tccccacccg gtgggtacga
    12121 ccggctgacg aaggggcgag aggcggccgc ggcccttgcc cgtggccggg ccgggcgcag
    12181 tggcacgacc ggcacgacca cctcagcggc gtgcccgcgt gcccagccgg agccgaactc
    12241 accgccggcg ggttcctctc gcaggaccag tgccggacgc ttcctgaggt ccgcgcgcag
    12301 cagctccacg gcggcagcgg agtcaaggtc gagccggatc cggcggtcgg ccgcggtggt
    12361 ggcgtacacg atccgcggca cagaccagtc ggctcgccag cgctcgaaga gccgggacca
    12421 ctcgccgcgg ccgagatccg cgcgcagccg ggggtcgggc agccagcgcg ccgggctgag
    12481 cactgtgcgg ccgtggcgga tccggggcag gtacggcaga tccgcggcgg cgccccagtg
    12541 ccatagcggc caggagggag tgcggctctc gccgatctcg atcagcaggc gcaccgcgtt
    12601 cggcacggcg aggttcgggt tgagcgagtg gaacaccagg ggcgcgatct cccgtccgtc
    12661 ccgcagcgac accacggcga accggtcgaa gtccgcggtg atcccgaggt ggtcgagact
    12721 cagctcggac gggcgctcgg cgtacgcgcc gaacaccatc gcctcactgg tcaacctggg
    12781 cacctgcgtc acgttggcca tccggggatg cagcggcggc gtgaccacct gtgccggggt
    12841 caccccgtcc tcggcgacga ggtccgcggc caccgcgccg accttgtccc gcagctgcgg
    12901 gaccaacggc aggaaccggc cgaacaacgc gccgacccgg gtgaagttca cgtcaccacc
    12961 gccgacgagc cggaactcgc cacgccgcaa ggcgtcttcg gagtcggcga gcagctgcgc
    13021 gcagatttcc gcgtacgagc cccgctctcc gggggcgccc gggcgggcga gccgctcgat
    13081 ggtgtcctcg tccagcagca cctcacgctt gtcccgcgcg accgcctgct cggccagtgc
    13141 gagcaaggtg acatcgcgct cggattcgcc ggggcgcccg gtgctgaccg accggttgcc
    13201 cggcggcaac aggtacccgg ccggcgggcc gataccacgt tccgcgtcga gcagatcctt
    13261 gatgcccaca acggttccgg tgccgtaccg ctcgatgaaa tccatgcggt aggccgcgag
    13321 cgggtcggca ggggccagcc gcggcggggc cacccgccag gcgacttcag cggcggcggc
    13381 cagctcgtcc gcgacggcgg cgggcagcac gaggtcggca tccatgccga gatcgacgtg
    13441 cagcagctgc gcctggtcgt ggatgcctcg catggtggcc gtcacggcgc gcagcgcgtc
    13501 gagtccctgg ccgaccgggg tggcggcata gcggtcgagt tcgtcacgga cctttgccag
    13561 ctcgggcgcg ggaccgccgc gggcgagcac gtgcgcgatc ggatcctcgg tggtcgcggg
    13621 cgggcgcagg tcggtgacca ggaactccag tgccaccagt tgcgtgacca gtttggtgag
    13681 cacctcctcg cctgcttgcg ggaactccgc gccgagccgc gcgagcagta ccggaaaggt
    13741 gatcggggtg tgtgcggccg ccagtgcggc acgcaccgga cgggtgtgcc ggacggtgcg
    13801 ctcgcggtcg tccgggccgc gaacgccgct ttcctccggt accaagggaa gcaccagccg
    13861 gtcgccccgg aggaagcaga ggtcgttgcg gaccactcgt agccggcaga gcaccgccgg
    13921 atcggtctcg cggggccgga tcacctcggc cagccagctc aggtcgacgc gtacgtgcct
    13981 gcggtgcccg gtcccgacgc ggatcttcgg ctggtcgtcg aactgggcgg ctgccacgcc
    14041 ggccatcagt ccgaacgggg tcggccgctg cgtcatcctg gccaggtacc ggttgagtga
    14101 cagcgcggcg cggcgccgcc tggccggatc ggtgagtgca ccagagctga tcttgtccag
    14161 agcagcggcg agcgacgggc tggacacctc gatcgcctcg cggacatagg gatcagcaca
    14221 cacctcgcgc aggaacgcgt tcaccgcctc ggggcggtcc agttcctgcg gtgccgggta
    14281 atccccgtcg cccgacgatc gtgctgaaag ccgcacgatc gcgaagtcga gcgcgcgaaa
    14341 ccgggtgctg gttaccatca cagccctcct gggtcgtttg ctcgaagtgg acggccgttg
    14401 ctcggtgatc cggctggcgg aacgcctcga cgcgggcccg gacgtgggcc cggacgcacc
    14461 gtcggcgcgt ccgggccgtc acacggtcgt ccggctcaac tggtcagcac gaaccggaat
    14521 gagtgcacgc gacagatgtg cacggggatg tgcaggtgtt gagcgcggcg ctgtcgtgct
    14581 cggggtgttc cgccagcgcg acaccggact cgttgagatg cgcggcccag cctgcgcccg
    14641 ccacaccttc gattttcagg tcgagatcga attcacccac ggagttcact cctttacttc
    14701 ggctgccgcg tccgcgcctc ccggtacgaa ttccggcagc tgtgaaacga ggacagccag
    14761 cccgccagtg ctatttccgc tggcgccccg tgactcgcat cacaccccga tagtgcttgt
    14821 ccgtcaacga cattcaggct tgagtgaaag cgcgtcggga aaggtttacg gcccggccgg
    14881 agtggttaca cgctggcgaa tgcggctgcc ggtccgacgt tcgaatgtgc ctgcgaaagg
    14941 cgaagaaggg gccaccggcc cgccgacatc aacgtgcacg cacaaaacgg acgctacgat
    15001 tggcgtccgc gtctttcgct gaggtgagga tcgacaacgc ggcgcagacc gttctcagga
    15061 gtcgctcatg caggcgacga tcttcatgtc cgcactcgta gctcaggtga tcagcgccgg
    15121 acgtcgctgc tcgctggttt tgcgcccgag tcgccaggcc cagcgccatc cggccaggac
    15181 ggcgaccatc gtgccactga gcgcgagcgg gactgcgacc gcggctggcc cgtcgaagcg
    15241 ggcagtggtc agcacgatgg ccattgccca gatctgtatc acagtgaatg ggatagccac
    15301 ccatgcggcg aggtatccgc gtcgccatcc tcgcgggtcc ggtgcgggag tgtacgggtc
    15361 catgatctgt acctcctcgt gatgtcgtta ccgatcatga gaccgcatgc gcgccatctg
    15421 atctgcgtca cgtgacacac agatccacat ccgccgtccg gctggcgagc tgctcgtgtc
    15481 caggtaggac agtcgcgccg tgccagcgtg acgatttccc tgaggaaacc cggcgcaacc
    15541 ttcagtcttg acgacgtaat gtccgttcca ggaggcctag atgcagacca cccagatgcg
    15601 cgcggtcaac cgggacgcgg ccaactgcct gcaggtgcgc gaaaccgagc tgcctgcacc
    15661 cccggccggg caggtccggg tccgggtcga ggcggccggt gtgtcctacg gcgatctgct
    15721 gttccagcgc ggagtggtcc cgggcggccc gaaaaccccg ttcatacccg gctgtgacct
    15781 cgtcggtgtt gtcgacgcgg tcggctccgg ggtcactgac ctcgaaccgg ggcaacgggt
    15841 gtgtgcgctc gtcgtctccg gcggttacgc ggacggcatg aacctgccgg ccgagcgggt
    15901 ggtgccggtg ccggacggca tgagcgccgt cgacgctgcg gccgtatccc tcaactactt
    15961 catcgcgcac cagatgctgc accgcgtcgg caaggtcacc agcggttccc gcattctcgt
    16021 gcacggcgcg tccggtggcg tcggcctcgc gttcctgcag ttggccgagc acatcggcgg
    16081 cgtgaccgtg ttcggcaccg catcggcggc gaacctcgac ctgctgcggc gccacggcgc
    16141 catcgccatc gactaccgcg ccgatgactt cgccaacgtg atccgggaca acggcggcaa
    16201 ggtcgacgtc gcctacgacc cgatcggcgg cacccacttc atccgctcgt actcggtcct
    16261 gcgccgcggc ggcaggctgg tcgcctacgg ccagaacgac gcactgcgca acggaaagcc
    16321 gtccctgcgg atcggcgcta tcggtttcct ggcaggcatc gccgccccga agctgatccc
    16381 cgatggccgc acgaccggct tctacaacgc gttggcgctg gagaagacgc agccgcacgc
    16441 ctaccgcgag gacctgaccg aggtcctgtc cctcgcggcc gcgaacaaga tcgccgtccg
    16501 cgagctgatc accgtccccc tgcgcgacgc cgaggaggcg ctacagaggg tggaggcggg
    16561 cgtcgcgggc aagatcgttc tcgactgcac cgcctgagcc acgacggttc cgtgattttt
    16621 gtatagatca agtctatcga caccctgaag gatctggtga acgctctgcg accttccgtc
    16681 gcacccggcg tcgctggtac ccagcggtca gaagtgtcca actaaacggt tcaggcgtgg
    16741 cattggacgt atcgagtgtg acgatgtcag cagcgacgat tcgtggtctg atgtcctggt
    16801 ctgtcagtgg tggtgtggcg ctgtactcct ggcaggccgg gtgcgtggtc gcagcactgt
    16861 cgttgggagt ggacgtggtg cggttggtgg ccgagtggcg gcgggatcgg gtcgtgttgg
    16921 atctcgtgga gcgggcgccg tgcggcactg tcgtcaacat ttaccccgct gagctgctac
    16981 aggtgtgggt gggatcagtg gagaggcagg tgcgcgatgc cccaccggat cagtgagtgg
    17041 gacgcgcgcg aggtaggtga tttctaccgt caggaggcga aggcgctgtt tcgatacgga
    17101 taccgattaa tgcaaggaaa ccgtgccgct gccgaggaca tcgtccagga gactttccag
    17161 gaggcagcaa agcgctggac gatgctgcgt gctctggaag atagccgtcg acgggcctgg
    17221 ctgttcacgg tggcgcggaa caaggtcgcg gacaggtgga ggatcgacct tcgagaggct
    17281 ccagttctgg acgtactgtc cccggccgac aagatgtgcg atggcgtgga tgttcaccag
    17341 cgcgtcatcg actcgatcgt gctggacaag tgctggaagg ccattaaaca gatgccgtcg
    17401 cgtcagcacc aggtcgcgtg gttgcggtgg catgacggct gcgacacagc acaaatcggg
    17461 aaactgctgg ggatcaactc ttcaaccgtt cgcgtacatc tgcggaacgc ccgaacggca
    17521 ttgaagtcgg cggtcggacc tgaggtccgt ttcctcgatg aagctgccga cagaaatcag
    17581 gaggacgccg actgcagaga tccgattgga ggcgccgaag catgaacgaa gggcaagagg
    17641 gcgtcgggtc gaggccgagg tgcccagagc acgggccgca ggagccagcc caggtgatct
    17701 gtccggcgtg cctgaagcca ctcgagacac gcgacgatgc gcagcgggtg tcgggcgcaa
    17761 gtatcgggtc ggtgccactg gccgacatct atcggcgtct cggcgacgcg gtggaacgag
    17821 acatcgacga gttcgacgtg gacagaggag cggaacggct cgcggcttgg atgcaagcac
    17881 ctgccgacgc cgaaccggtg ccggacttgt cggcgactgc tctgtcgtcc agagcgatcg
    17941 gggtgaaggc cgttgactcc caggatcctc tggccgtgga caacccaatc agagccaagg
    18001 cgatcatcgt tcacctgcta tcagcgaaca cgccactgcc cgctgattcg ggtccatatc
    18061 cctttagcac agccgtgcgg aaccagcgtt tgctggagat cgagatttgg gagcagacag
    18121 gtcccgtcga atcgtcagac gtggagcaca atatccaaat cggacgtggg gtgttgcgcc
    18181 tgccgcccgg gctgcccgcc cactcgtcga tcgagatcac tttctccctg tccgaggctg
    18241 gcaccctggg cgtgcacgct gtcgaaccga attcaggtgc acagggccgc ttcgaactgc
    18301 aaatcggtga gacggtagcg gccgtgcggg ccgacattgt tggtgtggaa ctaaaatgat
    18361 cagactcact ggagtcgcgg gatgcattgg tcacgtcatc gccggttcct gcgccagtgg
    18421 ttcgggcaga cggccggtgt ggatgacatg cagggtgctg accgctcgcg tcaacgcaac
    18481 gtagagccgt tgcaagccac gctgttctgc ctggatgatg ctggccggtt cgacgactac
    18541 gaccgtgtcg aactcaaggc ccttgctcag ggtgaccggc gcgagggtga ggcggtcaag
    18601 gttcgtgccg tcgacgccca gcacagtgtg ctgaagtccg ttggccgaca aggctcgatg
    18661 aagttctgcg atgtcgtcgt cggcagcgat gagccctact gatccttccc gtgccagagc
    18721 ggaagcacag gttgtgatgg tcgccgcgat cttttcgtct ggcgttgtct cgacgatccg
    18781 gagggcatcg tcagactgac gaaacgaggc cggggaaccc aattccgggg cgatgtgcgg
    18841 cagaagacgc gccgcgaagt cgatgacctg cgccggcacg cggtagccgc gagtcagctc
    18901 ctcgatgtgg ccgcccggtc gatcgaggtg tgtgaggacc tcggtccacc cttgaacggc
    18961 cgacgggctc gtcgcctgtg ccaggtcgcc aaggacagtg cacgagccag ccatgcggcg
    19021 ggagatcgcc cggatctgca tcggactgag gtcttgtgcc tcgtcgatca cgacgtggcc
    19081 gagttttccc ggccggtcga ccaatgccgc gacctcgtca cggagagcca agtcgaggct
    19141 gctccaccgc atcgcccgca cactgcgcgg ccgaggcgtg aacaacaggg cgcgctgctc
    19201 gtcgacagag aggacgctgt ccgcggcacg agccaaatgt gcttggtcgg taaggagatc
    19261 gaagaccacg cgggctggat cgattgccgg ccacatcttt ccgacggccc ggttgatcac
    19321 cctgtggcga cggagctgat gcagcgtggc gctcgcgttc ccggcctgct ccatctgacg
    19381 cagcacgaga tgtgccagcc gctgagccag caactcgcgt ccggcaccgt aatcaacctc
    19441 gcggccaagg acatcgtcga tttgctcggc aaggtcctca gtggacagac gccacgtgcg
    19501 gtgctgatgc ttgatctcga ccgtctcgtc cagggggcgg atccgtgacc acaggtgacg
    19561 tcggatgacc tcagccatcc gggcatcacc cttgacccgg gccgcctgcg gatcgtcgac
    19621 tcgctcgacc gcgatgccct cgccgatcag ctcgtcgatg gtcgtctgtg aaaccgcgac
    19681 ttcaccaaga gcgggcagca cattgcggat gtacgagagg aacgagtggt taggcccgat
    19741 gacggcaacc ccaccgccct ttcgcaagcg ttgcccctcg gtgtagagca ggtatgccag
    19801 acggtgtagc cccactgcgg ttttgcctgt cccgggcgct ccctggatgc acaccgtacg
    19861 gtcgattggc gcgcgtacca ggctcatctg ctcgggctgg atcgtggcca cgatgtcgcg
    19921 catcggtcct ttacgcggac gttcgatctc cgcggccagc aatctgctgg actcgacctg
    19981 acgatcgatc ggttcgtcct cgaaggcggt caccacacct tcgtggtcga agccgtaccg
    20041 ccgacgaacc ttgacgccca tcggatcctg acggctggcc tcgtagaacg cccgcgccaa
    20101 cggggcacgc cagtcgatga ccatcggctc gccgtcgtcg tcacggacac cacggcgccc
    20161 gacgtacaca aagtcgctgt tcgggtagcc gagacgcccg aagaacagcg gcgcgccttc
    20221 cacgtcggac agttcctcga cgacctggat gcggaactgg cgcaacacgt ggttgaagta
    20281 tttgtcccca acggcttcgc cctcgcccgc gccggtggcc agcatcgtgc tgacctcctc
    20341 gcgcatgcgg gcgagttggg cacgacagac gtccatgtag tcgcgttcgg cgcgtatctc
    20401 gggctcgaca gagtgcatgg ccgtgccaga cctcacagtg cgggaaggaa aacttaactt
    20461 agtcaagtat acgacttggt caagttgttt actggggaaa gcgggactac gctcttcaca
    20521 tggaggaact cggcctgcgt gagcgcaaga agcgccgtac ccgtgacgcg atcgcggagg
    20581 cagctcttgc cctgttccag gagtcaggct tcgacaacgt cacggtcgcc gacgtcgcag
    20641 cggccgcaga ggtgtccaaa ccgacgctct tcgcctactt cccgaccaag gaagacctgg
    20701 tcctgcaccc gttcctggac acaacgagcc ccgcggaggt cgtccggaac aactccggtg
    20761 tgcccgcgct caccgccctg cgtcagagct tcctcgatcg cctcgccaac cgggatccgt
    20821 tgaccggcct gaacgactcg ccgtcgacga tcactttcca tgacctgctg tactcaacgc
    20881 caaccttgat ggcccgcctg gccttctaca tgatcgacca ggaaaaagag ctggtcgcgg
    20941 aactgcgggc cgccgtcccg gacgccttca cggcccgggt gctggccgcc caggtcttcg
    21001 gcacccagcg aatcctctcc acgcacaacg cgcaggagat tcgaaacggc cgcaccgccg
    21061 acactgtcta ccccgcggcc gtcgcccgga cggaagccgc ctacacgttc ctggaatccg
    21121 gcctggcagc actcggcgcc tcgacgacga cggcccgcaa ctgacgagat cacgtaggca
    21181 ggtcggccgc gccgacagtt ccggcggtag ccgctcggtc acataccgct ggggatctgt
    21241 cacgcaaggg aagaggcgcg cgtgatgttc ttcatcctat cgagggacaa gtgaatcgtt
    21301 tcccggattc ggctgccccg gcggccctgt tctcaagtgg acattcgaat tgatcgagtg
    21361 cggaccctgg gattcagaag atcgtttctg atcgaatcgt ccgtcaggcg acaccttatg
    21421 gagatatatg cagctgttat atgcgaatac cgtccgaaaa ggacattgaa gaccggttgt
    21481 gccggtttca cgttgtccat ggtgggaagt ttccggagaa tggtcttctg gggcgctggg
    21541 gcagggcggc tgtggttgtg gcgcacttcg ccgatggagt ctgtaacggt gtgacggtac
    21601 gacgttttgg tcacgatgag tgtgcaattt gcaacgcttt cgggtggacg taatgcacga
    21661 acggagtacc gtcccggcgg actaaccggg ggtactgtga cgcggacgtg gaacgccgac
    21721 gaccgacacg aatctgacga gtgcgaatgg tgaataacca ctacctgaac acgttgttgc
    21781 agaatagtcg cctggcgcgc cgatatcgcc ccgtggtgga aaaggtccgt gccacctatc
    21841 agcgtgaagg tctcgaagga ctggtgcgac agggccgacg ggtcaccgcc cggctgctga
    21901 tgcccaagga ccccgcccct ggctccgccg gagcccgcgg cgcggcgcac accgccatcg
    21961 accctgccgt cgtcaacgac atcctgtcga acctggccat ccgggactgg cggatcgtgg
    22021 gccggctgct ggcgttgttc gacgagatgc accggcagaa cccggacccg cgggtgaccc
    22081 agatgctctt ccagctggac gagctggtca cgcagttgcg gcacgaccat cgcaagaagc
    22141 tcgtgctggc aggcaggcgg ccacccggcg ggcagccggt cgcccagccg atgctcgcgg
    22201 tgatccgcgg cggcatgtcc agcgccccgg ggtacgcgcg ggtgcggatc cgtgatctgg
    22261 tgccgctggc cgtggtcggc gatgccgcca aggacgtcag cggcatcctc accgaactga
    22321 tgaccaacgc gctgcatttc tccccgccgg agtccccggt caccgtccac gccaggatgg
    22381 ccgacggtgg cgccgtgttg ctccgcgtgg aggacgaggg catcggcatc gaccaggccg
    22441 agctcgatcg gctcaacggc gagctgctgc ggccgccggt gcgcagcctg ctcgacctgc
    22501 gggaccggca gatcctgcag cacctgggct tggtgaccgc gaccattctg gccaagccgc
    22561 acggcatcgg gctcagcctg gcccgccggg acccggccgg tgtcgtggca tccgtcctgc
    22621 tgccaccgga tctgctgtgc gatccggcga tggccgaagc cgagacgagc gcggcccgcg
    22681 ccgaagccga gacgaagccc gcaggccgtc cccagatcgc actgacgtcc gatcatgccg
    22741 agcgcgagca cgagacgact ccgttgggcc tgcccaaacg gacgacgcgt ccttctcccc
    22801 gcgtagggac gacgcccgag gacgacgcca ccgagccggg gtcgcaaggg cgccatgccc
    22861 gcacaaccga tctgccggag gacgcgcgca ccactgcagg cgggctgccc gtgcgcaggc
    22921 ccggccgggt gcgtgagttc tccgccgcgg acaccgatcc tggcctggcc gagcgtgagc
    22981 ccgtcgagta caccgaactg gacccggcgc agttacgacg gcgtgcggcc gccatgacgc
    23041 gcgtccggca cgcggccgcc gacgacccgt cggacaagcc cgcgcggccg acgccctacc
    23101 cgaaggccaa acccgacacg aatcccttgt tcacgagttc cgaggaccgt aatgacgcct
    23161 aacgccgcac agattcccga cgcactgcgg gaggaattcg ggtggctcgc agacaacttc
    23221 gtcagtgatg ttcccggtgt cgtccacgta ctggtcgtct ccgccgacgg gctgaaggtc
    23281 gccaagagca agggtctgca cgacgacgcc gccgaccagt tctcgtcact ggtggccatg
    23341 atgctctcca tcgccaaggc gtcggccggg ctgttcggcc gcggtggctt ccagtacagc
    23401 gacatcgtca tgggggacag cttcatcgtc ttccagcaga tcagtgaaca cagcggcgtc
    23461 gcggtgctgg ccagtgagca cgacggcggg cagctggaga cggtctgctt cgagctcgcc
    23521 aagttcgtca accagtcccg tcgggtgctc aaccccggga tgcgcaggca atcgcacacc
    23581 acagccacgc caacgggaca aggctgactg ccgaggagga catccggtgg acaccaccga
    23641 gtcgcctgag ggcgaatggg tccggccgtt cgccgtcacc ggcgggcgcg ccatcatcga
    23701 gcaggacctg ctgctcgaaa cgatcatctc cggatcgaac ggccgggggg acgacgactt
    23761 cgccgcgtca ctggacccgg agacgcgtgc ggtctaccac cacgtcagcc ggacgagctt
    23821 gtcgctggcc gaactgtcgg cgcagctgag gctgccgctc ggcgtggtgc gcgtgctggt
    23881 cgacgacctg tcgcgtgccg gccgcgtccg ggtgcacccg aacgcacaag gacgggaacg
    23941 cgatccgcag gtctacctcc gggtcatcaa cgggctgaag cgaaagctgg aggaggacag
    24001 ggccagccat gcgatctgac ccggcgtcag tgaagatcgt gatcagcggc ggtttcgggg
    24061 tcggcaagac cacgctgatc gggtcgatct ccgagatccc gcccgtgcac accgaagagg
    24121 tgatgaccga ggcgtcggaa ggcgtcgacc cggcaccggt cgagggcaag accaccacca
    24181 cggtcgcgtt cgacttcggc cggctcaccc tcgacgagaa cttccagttg ttcctgttcg
    24241 gcacgcccgg gcagggccgg ttctggttca tgtgggacga cgtgtgccgc ggtgcgctgg
    24301 gtgcgctcgt gctcgccgac gtcaaccgga tcacagacgc gttcgcggtg atcgacta
//
