LOCUS       NZ_FWXV01000006        22081 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Kibdelosporangium aridum strain DSM 43828, whole genome shotgun
            sequence.
ACCESSION   NZ_FWXV01000006
VERSION     NZ_FWXV01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kibdelosporangium aridum
  ORGANISM  Kibdelosporangium aridum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Kibdelosporangium.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900176515.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:02:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,283
            CDSs (total)                      :: 11,193
            Genes (coding)                    :: 11,032
            CDSs (with protein)               :: 11,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 3, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 38 of 161
            Pseudo Genes (incomplete)         :: 135 of 161
            Pseudo Genes (internal stop)      :: 6 of 161
            Pseudo Genes (multiple problems)  :: 17 of 161
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:58:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 47251
            Orig. end                         :: 69332
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FWXV01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22081
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="1"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22081
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22081
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12081](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12081)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(1473..1488)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    1589..1602
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.96"
                     /tool="antismash"
     misc_feature    complement(1648..1661)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.39"
                     /tool="antismash"
     gene            1797..5300
                     /locus_tag="B9C43_RS30825"
                     /old_locus_tag="SAMN05661093_06281"
     CDS             1797..5300
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024972.5"
                     /locus_tag="B9C43_RS30825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06281"
                     /product="M12 family metallo-peptidase"
                     /protein_id="WP_200825771.1"
                     /transl_table=11
                     /translation="MARSSLPTRGRSLAALAIAGMSLALLPVFGTVAPAESENPWTKVE
                     GNPVAARSARQADIRTDKFAGFTLDRDAMQADLSLAPRAATAGKQVLLPTPEGTFERFA
                     LLDAPVMEEKLAAAHPEIKTYSGRGIDDPTATVRADLTPLGFHASVRSKRGQYYVDPYY
                     HKDQSLYASYYGHNLRNDAGPLVENEEIEEVLQDALPTDAGPIVKLRTYRLALVTDPSY
                     ANYFGAENVTAAKVTLVNRVAQIYEDETAIRLVLINDTDKTNLNTPAQATGANGPCGAA
                     PCFTTTQLAGCSSTLLNRNQIVLGQLVGAGNYDVGHIGLGLDGGGVAGLGVVGGSGKAR
                     GCTGLPTPVGDFFAVDYVAHELGHQFAGNHTFNGTQGSCSGANRSAANSYEPGSGSSIM
                     AYAGICAQDNLQPHSDPYWSQRSFTEISTFISTPRAAINEVQNVGLREFDGTDSFTLSY
                     NGQASAPIVRGTNYTAAGIKAAIEGIQGWPAGATVTVSGFGGSLFNDTGFQVTFQSGPV
                     AAVDVPALGFTGTGTSAVVGETVDGGPQENTGFKVEDTTNHAPVVTTAPQYTIPLRTPF
                     SLTGSATDADGDKLTYLWEQNDRGGSAGTGLVNNVKTNGPLFRQFGTAAIVSDEDSLKY
                     HSPGQNAVNDNPTRVFPDMLQVSLNNTNAEAGTCPAAPAPPAVVPAAVVDCYSEFLPTA
                     DWVGFNNDRTLHFRLTARDYRAGGGGVGSADTALVLAPNTGPFLVTSQGANVTYPGGSA
                     QEITWDVAGTNAAPINATDVKISLSTDGGVTFPHVLSERTANDGSETVSLPDVATQKAR
                     IKIEAVGNVFFDLNNADFTILGAPKIASPSGASVQYSDAASFPVTATDPDSPVEGLTAT
                     AAGLPAGLSLTQAGPGSWTVSGTATAAPGDYQVSVSVTDQTGVVGKSAFAIKVAPEDAA
                     VTYTGDSMVDGGTVQLRATVQDNTDATPGDVLSGTLTFTAGDQTLCTAALALLGTGPTD
                     ASGNCTATLPAGVHEVTASVGGNYTGKAPGRVEVTNSQNRLVIGDGSVPLSKAYGADNG
                     SKADFTLAVAHFKGQSSGASLVTFTSGGKKYQIRSIRVDSFGSNATGAIDMRSRADLVD
                     VTDHWRPKTVATGLTLRVTGKVKDGLAFTLIDGSKLVFSTAWTGASTAVTKLARGSLVV
                     L"
     misc_feature    1812..1814
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5342..6163)
                     /locus_tag="B9C43_RS30830"
                     /old_locus_tag="SAMN05661093_06282"
     CDS             complement(5342..6163)
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-260). E-value:
                     4.2e-28. Score: 90.5. Matches aSDomain:
                     nrpspksdomains_B9C43_RS30830_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006349518.1"
                     /locus_tag="B9C43_RS30830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06282"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_084430444.1"
                     /sec_met_domain="PF00561 (E-value: 1.9e-21, bitscore: 72.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.3e-19, bitscore:
                     65.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPVAEGVELNVAVQGSGSPIVLLHGFPQTHLMWRHVAADLAAD
                     HTVICPDLRGYGDSDKPKTGYDKRTMAQDIVEVARHLGFEKFALAGHDRGAHVAFRAGL
                     DHPDTVTHLAMLDILPTLDMWDVLHGANAAVGFHLYLMAQPPGLPEQMINAAPDAFFGY
                     FLDAWSNSPFPEDIREAYLKASRDAVESIVADYRATATVDIEHDTQDLGKTLKMPVTVM
                     QQDWGAALSYDAKARWQKWAPELTHITVNSGHFMAEESPAEVIKALRDLLA"
     aSDomain        complement(5384..6103)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9C43_RS30830_Abhydrolase_1.1"
                     /evalue="4.20E-28"
                     /label="B9C43_RS30830_Abhydrolase_1.1"
                     /locus_tag="B9C43_RS30830"
                     /protein_end="260"
                     /protein_start="20"
                     /score="90.5"
                     /tool="antismash"
                     /translation="PIVLLHGFPQTHLMWRHVAADLAADHTVICPDLRGYGDSDKPKTG
                     YDKRTMAQDIVEVARHLGFEKFALAGHDRGAHVAFRAGLDHPDTVTHLAMLDILPTLDM
                     WDVLHGANAAVGFHLYLMAQPPGLPEQMINAAPDAFFGYFLDAWSNSPFPEDIREAYLK
                     ASRDAVESIVADYRATATVDIEHDTQDLGKTLKMPVTVMQQDWGAALSYDAKARWQKWA
                     PELTHITVNSGHFMAEES"
     gene            6227..9139
                     /locus_tag="B9C43_RS30835"
                     /old_locus_tag="SAMN05661093_06283"
     CDS             6227..9139
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005153615.1"
                     /locus_tag="B9C43_RS30835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06283"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_084430445.1"
                     /transl_table=11
                     /translation="MGSSVWFGVLGPLVASDSAGPIDLKGPRHRAVLARLLVARGRVVP
                     VDMLVNDLWDDPPDGAVGAIQTFVAALRKALEPDRPPRTPAQLLVTSGPGYALRAESVD
                     AWDFEAALGGSLSDLDSALALWRGPAYAEFTDQPWARAEIARLDELRLLAIERRAEALL
                     GLGRAAEAVPELQAHVDGHPWREDAWRLLALAQYRAGRQGDALESLRRARQVLSAELGV
                     DPGPALRQLEADVLAQAPELTPADVPVLVGRSHEMEQLSDAAAEVLRTGRLGLALISGE
                     AGAGKTALASAFQARLGWPSRWSSNLEDAPAGWFLDPIEVTDPSTARFQRYQAARTQLA
                     SAGRLLIVLDDLHWADEETLSLVASVVADPVDAPVLLVGTYRTTDAPTAFLGRVARSEP
                     TRVYLSGLSMSDIPAVVHSAVGLDVDDDTASVIHRRSGGNPFFVRELARLVAAGSDLSA
                     VPAGVRDVVKYRLSRLPAEVQSVLRTASVVGESFTLDVAGSLDAVEVAVQHGFLVEVAA
                     QEFRFSHALVRDTLYQDLSQTRRAHLHLAVGSALERVRPDDVAALAHHFSLASDPRAAG
                     YARAAASLAEARFDFGEAARLWRIALASASADRLELIMGLVRALSFTGSLGQARELRAS
                     ALDLLGPVDDPELAARVIASFDVPAIWTTPDDPALAARVVAVTERVLPSVTSASRSRLL
                     ATIAMELRSSGGHRAVAAASEAVAIARTLDDPAVLAFALNAQFMQSFSRAGLAPQRVRI
                     GTELVDVASRNSLVTFEVLGHMILMQAHSALAAFAEADTHAAEVTRLGRDYQLPLAEVF
                     VQWYRALRTSVAGGDAAPLYRAAFLAGTEMPGLGDGILSFALLCHQLRNGLPVSRDLDF
                     GVYEPWCRPGGVIPPSPHDLLFEARTCLHAIAAVERGDRESMAELYDVLLPAAGELAGA
                     GSGLLTLKPVAYYLGGLARGLGRHREAAQHDKQAAALATP"
     gene            complement(9129..10004)
                     /gene="pqqB"
                     /locus_tag="B9C43_RS30840"
                     /old_locus_tag="SAMN05661093_06284"
     CDS             complement(9129..10004)
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079182.1"
                     /locus_tag="B9C43_RS30840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06284"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_033381766.1"
                     /transl_table=11
                     /translation="MKVLLLGTAAGGGFPQWNCACRMCEAGLPARTQDCIAISADGTGW
                     YLVNASPDIRTQILSTPALAAGPGPRDTPLRGALLTDAELDHSLGLTMLREGAGLSVWA
                     PAAVLHALRTDFPLQEIVSRYGAWNWRPAAGNFEIDGLTVTVFPISDKKPKYVQSTVDG
                     PWVVAYKISDPSGGAVVYAPCLKTWPEGFDELIADASCVILDGTFYSPDEMSGATNKGV
                     GSGAQRAMGHIPIAGPEGSLAQIARHPGKRWIYTHLNNTNPILDPESKEYKEVLAAGAQ
                     APFDGTVITV"
     gene            complement(10001..11095)
                     /gene="pqqE"
                     /locus_tag="B9C43_RS30845"
                     /old_locus_tag="SAMN05661093_06285"
     CDS             complement(10001..11095)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680417.1"
                     /locus_tag="B9C43_RS30845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06285"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_143446771.1"
                     /sec_met_domain="PTHR43273 (E-value: 2e-32, bitscore:
                     107.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 6.8e-24, bitscore: 80.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9.3e-07, bitscore: 24.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.4e-13, bitscore: 46.4,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-12, bitscore:
                     43.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAQPPLGMLAELTHRCPLHCPYCSNPIELVTRENELSTDEWLSV
                     IDQARELGVLQVHMSGGEPLARPDLPVLVERASDLGCYVNLVTSGLGLTEERLTDLVDR
                     GLAHVQLSVQGADAEMANRIAGVKAHAHKLAAARAVKKLDMPLTVNVVLHRANHHQVAD
                     LIALAEEMGADRLELANTQYYGWGLRNRSALMPTAEQLAEAEPIVRAAIERLRDTMQIV
                     YVVADYYEPYPKPCMYGWGSRQLTVAPNGDVLPCPAASSITTLKLDNVRSQSLEEIWYR
                     SESFNAYRGDHWMPDPCRSCSRKGIDFGGCRCQAFLLTGDAGATDPVCSKSPDRGVIDT
                     ILAGTPSEPPELVMRKNTIKVVSS"
     gene            complement(11092..11364)
                     /gene="pqqD"
                     /locus_tag="B9C43_RS30850"
                     /old_locus_tag="SAMN05661093_06286"
     CDS             complement(11092..11364)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336984.1"
                     /locus_tag="B9C43_RS30850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06286"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_407657132.1"
                     /sec_met_domain="PqqD_RRE (E-value: 9.1e-26, bitscore:
                     84.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.7e-13, bitscore: 43.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMIGLDSAPRLRRGVRLTYDKTRETHVLLFPEGVLVPNQTAAAV
                     LKLCDGTATVAQITAELGKNYDGVRADDVQNVLKRLEERRVVEWK"
     aSDomain        complement(11101..11358)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B9C43_RS30850_PqqD_RRE.1"
                     /evalue="4.30E-27"
                     /identifier="RREFam006.1"
                     /label="B9C43_RS30850"
                     /locus_tag="B9C43_RS30850"
                     /protein_end="88"
                     /protein_start="2"
                     /score="84.7"
                     /tool="antismash"
                     /translation="MIGLDSAPRLRRGVRLTYDKTRETHVLLFPEGVLVPNQTAAAVLK
                     LCDGTATVAQITAELGKNYDGVRADDVQNVLKRLEERRVVE"
     gene            complement(11368..12081)
                     /gene="pqqC"
                     /locus_tag="B9C43_RS30855"
                     /old_locus_tag="SAMN05661093_06287"
     CDS             complement(11368..12081)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631254.1"
                     /locus_tag="B9C43_RS30855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06287"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_235038945.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.3e-81, bitscore:
                     268.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSISPSTSNTLLPADEFVGQLRGLSHRYWGTHPFHRRLHDGSLSE
                     FELRTWAANRWYYQCMLPQKDAAIISNCPVPRIRRDWLARIVYHDGTAEGEGGRERWLR
                     LCEAVGLTREEVLDERHVAPGVRFAVDAYVTFARTKPWVEAVASGLTEMFSGHLMRQRV
                     TDMLSNYAWIRREDLAYFTNRIDVVSGEGQATVDIVVEYCKTRAEQEKAIAALSFKCNV
                     LWSMLDAIEQAAKKE"
     misc_feature    complement(12147..12160)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     gene            complement(12161..12262)
                     /gene="pqqA"
                     /locus_tag="B9C43_RS30860"
     CDS             complement(12161..12262)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="B9C43_RS30860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_033381771.1"
                     /transl_table=11
                     /translation="MIENTEREVWTTPDFVEYETPMEVTAYAARMDD"
     misc_feature    complement(12227..12242)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.23"
                     /tool="antismash"
     gene            12567..13556
                     /locus_tag="B9C43_RS30865"
                     /old_locus_tag="SAMN05661093_06288"
     CDS             12567..13556
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631253.1"
                     /locus_tag="B9C43_RS30865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06288"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_033381772.1"
                     /transl_table=11
                     /translation="MTFRRKLAVAAASATTVMLAAGTATAAPADVQPLAIKQVASGLNQ
                     AWAVDFLPDGTALFTEKDSRKIRKIAPNGQVSDVQTISGVSVTKEAGLLGIAVSPTYAT
                     DQLVFIYYTTSSDNRIAKLKLGQAPTPIVTGIPRGSQYHHGGRIKFGPDGYLYAGTGDG
                     QNGANAQNRNSLGGKVLRVDKNGAAAPGNPFNSRVYSLGHRNVQGLAWVGTQLYISDIG
                     ASKVDELNKITPGGNYGWPSCEGPCSNPAYTNPVKTWPTSQATPSGLTYYKGSLFMASL
                     KGGTFKLNTSGAGGKLYTNLGRTRDEVAGPNNVLWVVTPGGIYNADGS"
     misc_feature    13639..13654
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     gene            13877..14245
                     /locus_tag="B9C43_RS30870"
                     /old_locus_tag="SAMN05661093_06289"
     CDS             13877..14245
                     /EC_number="7.1.2.2"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150340.1"
                     /locus_tag="B9C43_RS30870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06289"
                     /product="F0F1 ATP synthase subunit epsilon"
                     /protein_id="WP_033381773.1"
                     /transl_table=11
                     /translation="MAEISVELVAVERRLWSGKATMVIAQTTEGELGVMPGHEPLLGQL
                     VEGGVVKVRTTDGETVIAAVYGGFLSITGDGVSILAENAELAEEIDIDQARADVAAAQD
                     ADERARAEARVRAAGQTV"
     gene            14271..14738
                     /locus_tag="B9C43_RS30875"
                     /old_locus_tag="SAMN05661093_06290"
     CDS             14271..14738
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020640979.1"
                     /locus_tag="B9C43_RS30875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06290"
                     /product="DUF2550 domain-containing protein"
                     /protein_id="WP_033381774.1"
                     /transl_table=11
                     /translation="MEILWFIGTLLAVAAATLLLLGIRRVRLIRMGGINVALRTHLDNP
                     RGWHLGVARYHGDEFTWYRALSLRNGPNRIIQRDGFEIDDRREPEAQELYGVPNGAIIL
                     RCRAELDPPRSKRAFGGPDTVVEIAMTPDALTGFLSWLESAPPGRRLPYAS"
     gene            complement(14735..15484)
                     /locus_tag="B9C43_RS30880"
                     /old_locus_tag="SAMN05661093_06291"
     CDS             complement(14735..15484)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021604.5"
                     /locus_tag="B9C43_RS30880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06291"
                     /product="anti-sigma factor domain-containing protein"
                     /protein_id="WP_084430448.1"
                     /transl_table=11
                     /translation="MNNDVHTLTGAYVLDALSEMERRAFEDHMSGCPACHQEVAELRET
                     TARLGTATAAAPPPQLWHKVHAAIGNVRQLPPMSFDEPQRLRPRRGSSRFAVFAAAASL
                     LVAAGLGVGWVVTNNDVKDELAQTQTELSRLQTLLSAPDAKIVTGPVKGGGTATAVVSP
                     SQNGMVMTLKGAPALPGTSVYQLWYVRHLNAGGQTSAGTLPVPNGAISSNDLRPAQGAV
                     ALAITVEPAGGSTTPNLDALVVKLDLA"
     gene            complement(15481..16071)
                     /gene="sigK"
                     /locus_tag="B9C43_RS30885"
                     /old_locus_tag="SAMN05661093_06292"
     CDS             complement(15481..16071)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene="sigK"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020660631.1"
                     /locus_tag="B9C43_RS30885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06292"
                     /product="ECF RNA polymerase sigma factor SigK"
                     /protein_id="WP_033381776.1"
                     /transl_table=11
                     /translation="MRERAQRSREPGGPRPATLDELLPRVARGDETAFEQLYRHLSAPI
                     FGLVQRILRDPAQSEEVAQEVFLELWRSATRYSPERGSVLSWAMTIAHRKSVDRVRSAQ
                     ASTDRDSRVARAETARPFDEVTEVVAGRMEREQVRRCLGTLTELQRESVMLAYYQGYTY
                     REVAHLLDSPLGTVKTRLRDGLIRLRDCMGVTA"
     misc_feature    complement(16108..16123)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 25.13"
                     /tool="antismash"
     gene            complement(16271..16627)
                     /locus_tag="B9C43_RS30890"
                     /old_locus_tag="SAMN05661093_06293"
     CDS             complement(16271..16627)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010315918.1"
                     /locus_tag="B9C43_RS30890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06293"
                     /product="hypothetical protein"
                     /protein_id="WP_084430449.1"
                     /transl_table=11
                     /translation="MDDFEAQLKELIARGFSFAHPRDATGEVAAVVGVRVHHGVVDVVQ
                     IYGEHDADATRIPGDEMDIFFPYKVFWRSSGTSAAVVAELLALPDPEPGDVPKVNGCWV
                     PARPGRSKWLSASA"
     misc_feature    16638..16654
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.59"
                     /tool="antismash"
     gene            complement(16641..16877)
                     /locus_tag="B9C43_RS30895"
                     /old_locus_tag="SAMN05661093_06294"
     CDS             complement(16641..16877)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944996.1"
                     /locus_tag="B9C43_RS30895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06294"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_084430450.1"
                     /transl_table=11
                     /translation="MTAVHNGVSADRLGGVDWRRSRMSGAVGNCVEVATLESGEIAVRN
                     SRFPDGPALIYTRAEMAAFLAGAKDGEFDDVLL"
     misc_feature    16968..16981
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.23"
                     /tool="antismash"
     misc_feature    17252..17265
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            complement(17669..18535)
                     /locus_tag="B9C43_RS30900"
                     /old_locus_tag="SAMN05661093_06295"
     CDS             complement(17669..18535)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944997.1"
                     /locus_tag="B9C43_RS30900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06295"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_033380832.1"
                     /transl_table=11
                     /translation="MPTGEPAGSGPTARRMVLGSQLRRLREAKGISREDAGYAIRGSGS
                     KISRVELGRVSFKERDVADLLTLYGVTDQSDRDIFLALVRESNQPGWWQRYNDLMPHWF
                     QDFVGLEESASRIQTYEVQFIPGLLQTEDYARAVMLRGRPDAPPEEIDRRVNLRMQRQR
                     LLASPQAPRLWAVVEEACIHRQMGGRKVLRDQLEHLLDLTKMSNISLQILPFELGGSAA
                     ETPFTLLRFAEPELPDIVYLEHLCGALYLDKTDEVEVYNKAAHRLVVEAETPEQTRRTI
                     SKVLKSL"
     gene            complement(18614..19192)
                     /locus_tag="B9C43_RS30905"
                     /old_locus_tag="SAMN05661093_06296"
     CDS             complement(18614..19192)
                     /EC_number="2.5.1.17"
                     /GO_function="GO:0008817 - corrinoid adenosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229518.1"
                     /locus_tag="B9C43_RS30905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06296"
                     /product="cob(I)yrinic acid a,c-diamide
                     adenosyltransferase"
                     /protein_id="WP_033380818.1"
                     /transl_table=11
                     /translation="MAVHLTRIYTRVGDDGTTGLGDFSRVSKTDPRLAAYADVDEANAA
                     IGVVVATGNLPDEIVTVLRAVQNDMFDVGADLCNPIVEDPKYPPLRITSDYITRLENWC
                     DEFNERLPKLTSFILPGGTPGAAYLHVARTVTRRAERATWALIEADADRTNVLAAKYLN
                     RLSDLLFILCRLANPDGDVLWQPGGAGTN"
     misc_feature    complement(19354..19367)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 22.87"
                     /tool="antismash"
     misc_feature    19411..19427
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.95"
                     /tool="antismash"
     gene            19484..20203
                     /locus_tag="B9C43_RS30910"
                     /old_locus_tag="SAMN05661093_06297"
     CDS             19484..20203
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019349.5"
                     /locus_tag="B9C43_RS30910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06297"
                     /product="FadR/GntR family transcriptional regulator"
                     /protein_id="WP_160096788.1"
                     /transl_table=11
                     /translation="MKVKSAAEQLVDRLITAIALGALLPGQKLPPEREFAARLNVSRTT
                     LRDALHQLESLGYVGITRGRSGGVRVHSTWGPESGSHIRSMLLPRWQHLTWLFDLTRSL
                     LPMIAGLAAERRTDEHIRKIWAAVEAYEKAEDRDVMRTADHTLHSAVAEATGNPYYVSI
                     DSQLRIQLTFGTDSLPYDTEIRQRALDDHRAIAEAIEAGDSARAADLTMHHFVELAEKP
                     MLRLRQRVEAAGASESE"
     gene            20261..21532
                     /gene="murA"
                     /locus_tag="B9C43_RS30915"
                     /old_locus_tag="SAMN05661093_06298"
     CDS             20261..21532
                     /EC_number="2.5.1.7"
                     /GO_function="GO:0008760 - UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019277 - UDP-N-acetylgalactosamine
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="murA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657302.1"
                     /locus_tag="B9C43_RS30915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_06298"
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="WP_033380817.1"
                     /transl_table=11
                     /translation="MSEHFRVHGGARLVGEVDVVGAKNSVLKLMAAALLAEGTTTLTNC
                     PQILDVPYMADVLRSIGCEVSVDGDTVVITTPSELNHKPDAASMGKLRASVCVLGPLVG
                     RCRRAVVALPGGDAIGSRPLDMHQNGLRQLGATSEIEHGSVVAEAEGLHGAQIWLDFPS
                     MGATENILMAAVLADGTTVIDNAAREPEIVDLCTMLQQMGAKIEGAGTSTLTVHGVETL
                     QPTEHRVIGDRIVGATWAFAAAVTRGDLTVRGVDPHHLDLVLDKLRTAGAEVTVYDDKA
                     FRVVMAERPKSVDFVTLPYPGFATDLQPFAIALCAVSEGTAMITENLFEARFRFVEEMM
                     RLGADARTDGHHAVIRGVEKLSSAPVWASDIRAGAGLVLAGLCADGVTEVWDVFHIDRG
                     YPGFVENLVRLGANVERVTQAPER"
ORIGIN
        1 ggcgaccggc accgcactga cgaacaacgt caagaaggac ggcccgctgt tccgccagtt
       61 cggcacgtcg gcgctggtca gcaccgagga cagcttgaag tactactcgc cggggcagaa
      121 cgcggtgaac cgcaacccca cgcgggtctt cccggacatg gaccagatcc tggcgaacaa
      181 caccaacgcc aagaccggtg cgtgcccgcc ggtgccgccg ccaccgacgc cgacgacccc
      241 agtgcctcag ccgctggtcg actgctattc ggagttcctg cccacggcgg actgggtcgg
      301 catcggcaac gaccggacca tgcacttccg cctgaccgca cgtgacgcca aacaaggcgg
      361 cggtgggatc ggattcgacg acaccgcgct gacgatcgcg cccagcgccg gtccgttcct
      421 ggtgacgtcg cagggtgctg ccggtgcgct ggccggaggt tcgaagcaga cgatcacgtg
      481 ggatgtggcc ggcaccaatg ccgcgccggt caacgcgaag aacgtgaaga tctcgctgtc
      541 caccgacggc ggcaagacct tcccgcacgt gctcgcccgc agcacgccga acgacggcag
      601 cgagcaggtg cggctgaccg acgaggcgac gaccaaggcg cggatcaaga tcgaggcggt
      661 cgggaacgtc ttcttcgacg tcagcgacgc cgatttcacg atcaacgcct cgccgcgggt
      721 gaccagcccg cagaacatcg ctgtccagta cagcgacgct ctcgcgccgg tcacgatcac
      781 cgccgaggac ccggacagca agggggcggc gctgaccgct gccgtcaccg gcctgcccga
      841 agggctttcg gtggctgagg gcacggccgc ggacaacaag cggacgtgga cgatttccgg
      901 gaccaccaag gcgaaagccg gtgactaccc ggtcgcgttc acggtcaccg acgacaccgg
      961 tgtggcgagc acgctcaccg tgccgatcaa ggtgaagccg gaggacgtcg aggtcacgta
     1021 caccggagat tcgttggtgt acggcgattc cgtgctgttc cgggcgactg cccgggacaa
     1081 caccgacgcc actcctggcg acatcaagac cgcgaacgtg acgttctcgg ccggtggcaa
     1141 ggccttgtgc accgcgacca tcggtctgct tgggactggt gcgtccgacg ggtcgggtag
     1201 ctgcgtcggc aagctgccgg ccggcgtgac ctctgtaacc gttgcggcgg gcgggaacta
     1261 cgcggccagt gcgaccgctt cagtggagac acaggcttcg cagaagcgga ccgtgctcgc
     1321 cgccggtgtg atcaccgcga ccaagtcggc cggaacgtac aaggccgatc atggcacgcc
     1381 ggtcaacgtc acggcgttgc tggtgcacaa cgacgccaag acgaaaggcc tgagcacgct
     1441 gaagttccgc tcgggtggcc gtgagtacgt cgcgttcggc aacggcgtcg agtccttcgg
     1501 ggcgaagacg tccggttcgc tcgacgtgcg cacgaaggtt ctgctcagcg acgtgaccag
     1561 cggccaggcg atgttcgtcg cggcgaacgt cacgctgcgg gtgacgcaga ccgggcgcaa
     1621 cgtctcggtg accctgctgc agggcgacaa actgttgttc tcgtccgact ggacgggcgc
     1681 gaagacgcag gaaatcccgc tggcgaccgg tggattcctg atcgcataac ccattcacct
     1741 cgtgggtggt caccgcgctg gtgaccaccc acgaggtttt tcaaggagat agtcacttgg
     1801 cgagatcctc gttacccaca cgtggccgca gtctggccgc gctcgcgatc gcgggtatgt
     1861 cactcgcgct cttgccggtg ttcggcacgg tcgcaccggc ggagtcggaa aacccttgga
     1921 ccaaggtcga aggcaatccg gtcgcggcta gatcggcgag acaggccgac atccggacgg
     1981 acaagttcgc cgggttcacc ctggaccgcg acgcgatgca ggcagacctg tcgctcgcgc
     2041 cccgcgcggc cacagcgggc aaacaagtcc tgctgccgac gccggaaggc accttcgagc
     2101 ggttcgcact cctcgacgcg ccggtgatgg aggagaagct cgccgcagcc cacccggaga
     2161 tcaagaccta ctccggcagg ggaatcgacg acccgaccgc gaccgtacgc gcagacctga
     2221 cgccactggg gttccacgct tctgtgcggt cgaagcgcgg tcagtactac gtcgacccgt
     2281 actaccacaa ggatcagagc ctctacgcca gctactacgg ccacaacctg cgtaacgacg
     2341 ccgggccgct ggtggagaac gaggagatcg aagaggtcct gcaggacgcc cttcccacgg
     2401 acgcaggccc aatcgtcaag ctccggacct accgcctcgc gctcgtcacg gatccctcgt
     2461 acgccaacta cttcggcgcc gagaacgtga ccgccgcgaa ggtgacgctg gtcaaccgag
     2521 tcgctcagat ctacgaggac gagaccgcga tccgtcttgt cctgatcaac gacacggaca
     2581 agaccaacct gaacacgccg gcccaggcga ctggtgcgaa cggtccgtgt ggtgcggcgc
     2641 cgtgcttcac cacgacccag ctcgctggct gcagcagcac cttgttgaac cgcaaccaga
     2701 tcgtgctcgg ccagctggtc ggcgcgggca actacgacgt ggggcacatc ggcctcggtc
     2761 tggacggcgg cggcgtcgcc ggtctcggcg tggtcggcgg cagcggcaag gcccgtggtt
     2821 gcaccggttt gccgacgccg gtcggtgact tcttcgccgt ggactacgtg gcgcacgagc
     2881 tcggccacca gttcgcgggc aaccacacgt tcaacggcac ccagggctcc tgctcaggtg
     2941 cgaaccgcag cgccgccaac tcctacgagc cgggtagtgg ttcgtcgatc atggcgtacg
     3001 ccggtatctg cgcgcaggac aacctgcagc cgcactcgga tccgtactgg tcgcagcgca
     3061 gcttcaccga gatctccacg ttcatctcga ccccgcgggc ggcgatcaac gaggtgcaga
     3121 acgtcggcct gcgtgagttc gacggcaccg actcgttcac cttgtcctac aacggccagg
     3181 cttccgcgcc gatcgtgcgt ggcaccaact acaccgccgc cgggatcaag gccgcgatcg
     3241 agggcatcca gggctggccg gcgggcgcga ccgtgacggt gtccggcttc ggcgggtcgc
     3301 tgttcaacga caccggcttc caggtgacct tccaaagtgg accggttgcc gcggttgacg
     3361 ttccggcgct cgggttcacc ggtaccggaa ccagcgcggt ggtcggtgag actgtggacg
     3421 gtggtccgca ggagaacacc gggttcaagg tcgaggacac caccaaccac gctccggtcg
     3481 tgaccacggc gccgcagtac acgatcccgt tgcgcacacc gttctccttg accggcagcg
     3541 cgaccgacgc cgacggcgac aagctcacct acctgtggga gcagaacgac cgtggcggca
     3601 gcgcgggcac gggcctggtg aacaacgtca agacgaacgg tccgctgttc cgccagttcg
     3661 gtaccgcggc gatcgtcagc gacgaggaca gcctgaagta ccactcgccc ggccagaacg
     3721 ccgtgaacga caacccgacg cgcgtcttcc cggacatgct gcaggtgtcg ctgaacaaca
     3781 ccaacgccga agcgggtacc tgcccggccg caccggctcc gccagcggtt gtcccagccg
     3841 ctgtggtcga ctgctactcg gagttcctgc cgacggcgga ctgggttggc ttcaacaacg
     3901 accgcacgct gcacttccgt ctgaccgctc gggactaccg cgcgggtggc ggtggcgtcg
     3961 gcagcgccga caccgctctg gtgctggcgc cgaacaccgg cccgttcctg gtgacctcgc
     4021 agggcgccaa cgtgacctac ccgggtggtt cggcgcagga gatcacgtgg gacgtggcgg
     4081 gcacgaacgc cgcaccgatc aacgccaccg acgtgaagat ctcgctgtcc accgacggcg
     4141 gcgtgacctt cccgcacgtg ttgtctgagc gcacggccaa cgacggcagc gagaccgtca
     4201 gcctgccgga tgtggcgacc cagaaggccc ggatcaagat cgaggcggtc ggcaacgtct
     4261 tcttcgacct gaacaacgcc gacttcacca tcctcggcgc gccgaagatc gccagcccgt
     4321 ctggtgcttc ggtgcagtac agcgacgcgg cctcgttccc ggtgaccgcg accgacccgg
     4381 acagcccggt ggagggcctg accgcgaccg ctgcgggcct gcccgctggt ttgtcgctga
     4441 cccaggccgg acctggctca tggaccgtct cggggacggc cacggccgca cccggtgact
     4501 accaggtgtc cgtctcggtg acggatcaga ctggtgtcgt tgggaagtcc gcgttcgcga
     4561 tcaaggtcgc acccgaggac gccgctgtga cctacaccgg agactccatg gtggacggcg
     4621 gaaccgtgca gttgcgcgcg accgtccagg acaacacgga cgccacgccc ggcgatgtcc
     4681 taagtggaac gttgacgttc accgcaggcg accagacact ctgcacggcc gctttggccc
     4741 tgctgggcac tggccccacg gatgcttccg gcaactgcac ggccaccttg ccggccggtg
     4801 tgcacgaggt gacagcttcg gtcggtggca actacacggg aaaagcacct gggcgggttg
     4861 aggtcaccaa ctcgcagaac cgtctggtga tcggtgacgg ctcggtgccg ctgagcaagg
     4921 cctacggcgc cgacaacggg tccaaagcgg acttcacact ggcggtggcg cacttcaaag
     4981 ggcagtcctc cggggcaagc ctggtgacgt tcacctccgg cggcaagaag taccagatcc
     5041 gcagcatccg cgtcgactcg ttcggctcga acgccacggg tgcgatcgac atgcgcagcc
     5101 gcgccgacct ggtcgacgtg acggaccact ggcggccgaa gaccgtggcc accggcctga
     5161 ccctgcgggt gaccggcaag gtcaaggacg gcctggcgtt cacgctcatc gacggctcga
     5221 agctggtctt ctccaccgcg tggaccggtg cgtcgaccgc cgtgaccaag ctggcccgcg
     5281 gctccctcgt ggtgctgtaa gccctgttca aggaaggccc ccggtccgcc gggggccttt
     5341 ctcatgccag caggtcgcgc aatgccttga tcacctcggc cggggactcc tcggccatga
     5401 agtgcccgga gttgacggtg atgtgggtga gctcaggcgc ccacttctgc cagcgggcct
     5461 tcgcgtcgta gctcagcgcg gcaccccagt cctgctgcat gaccgtgacc ggcatcttca
     5521 gcgtcttgcc caggtcctgt gtgtcgtgct cgatgtccac tgtggctgtt gcccggtagt
     5581 ccgcgacgat ggattcgacc gcgtccctgg aggctttgag gtaggcctcg cggatgtcct
     5641 ccgggaacgg gctgttggac cacgcgtcga ggaagtagcc gaagaacgcg tccggtgccg
     5701 cgttgatcat ctgctcgggc aggccgggtg gctgggccat caggtacagg tggaagccga
     5761 cggccgcgtt ggcgccgtgc agcacgtccc acatgtccag cgtgggcagg atgtcgagca
     5821 tggccaggtg ggtgacggtg tccgggtggt cgagaccggc ccggaaggcg acgtgtgccc
     5881 cgcggtcgtg tccggccaga gcgaacttct cgaagccaag gtggcgggcg acctcgacga
     5941 tgtcctgagc catcgtgcgc ttgtcgtagc cggtcttggg cttgtcgctg tcgccgtatc
     6001 cgcgcaggtc agggcagatg acggtgtggt cggcggccag gtcggcggcg acgtgccgcc
     6061 acatcaggtg ggtctgtggg aagccgtgca gcaggacgat cgggctgccg gagccctgga
     6121 ccgccacgtt caactcgacg ccttcggcga ctggaatctt catggcacca gcgtgcgcgc
     6181 ggtcaatcag cagcggatca gcgtccgctg agtacagtgc tgagtgatgg gttcctcggt
     6241 gtggttcggc gtgctgggtc cgctggtggc gtcggactcc gcgggcccga tcgacctcaa
     6301 aggaccccgg caccgcgccg tgctcgctcg tctgctcgtc gccagaggcc gggttgtgcc
     6361 ggtcgacatg ctggtcaacg acctgtggga cgacccgccg gacggtgccg tcggcgccat
     6421 ccagactttt gtggccgcgt tgcgcaaggc actggagccg gatcgcccgc cacgcacccc
     6481 ggcccagttg ctcgtcacgt ccggtcccgg ttacgccctg cgcgcggaat cggtggacgc
     6541 gtgggacttc gaggccgcac tcggtggttc gttgtctgat ttggactccg cgctcgcgtt
     6601 gtggcgtggg cccgcctatg ccgagttcac ggaccagccg tgggccagag ccgagatagc
     6661 ccgcctggat gagctccgcc tgctggcgat agaacggcga gccgaggcct tgctggggct
     6721 cggccgtgcc gctgaggctg tgcctgaact ccaggcccat gtggacggac atccgtggcg
     6781 cgaggatgcg tggcggctgt tggctttggc gcagtatcgc gcggggcggc agggcgatgc
     6841 gttggaatct ctgcggagag cccgccaggt gctgtccgcg gagttgggag tcgaccctgg
     6901 cccggcgttg cgacagctgg aagctgacgt tctcgctcag gcgcctgagc tgacgcctgc
     6961 tgatgtgccg gtgctggttg ggcgttcgca tgagatggag cagttgagcg acgccgcggc
     7021 tgaggtgctg cgcaccgggc ggctggggct ggcgttgatc agcggggaag ccggtgccgg
     7081 gaaaaccgca ctggcgtcgg cttttcaggc ccgcctcggc tggcccagcc ggtggagcag
     7141 caacctcgaa gacgcgcccg caggctggtt cctcgatccc atcgaggtca cggacccgtc
     7201 gacagcacgt ttccagcgct accaagcggc gcggacgcag ttggcttcgg ccggacggct
     7261 gttgatcgtg ctggacgatc tgcattgggc cgacgaggaa acgctgtccc tggtggcttc
     7321 ggtggtcgcc gacccggttg acgcaccggt gctgctggtg gggacatatc ggacaaccga
     7381 tgcgcccacg gcgtttctcg gccgtgtcgc acgatccgaa ccgactcgcg tctacctcag
     7441 tggactgtcc atgtcggaca ttccggcagt cgtacattcg gctgtcggct tggatgtgga
     7501 tgacgacaca gcgtcggtga ttcaccggcg cagtggcggg aacccgttct tcgtcaggga
     7561 actcgcgcga ttggtcgcgg caggcagtga tctctcggca gtgcccgccg gtgttcggga
     7621 cgtcgtgaag taccggctgt cccgcttgcc cgccgaggtc cagtcggttc ttcgcaccgc
     7681 ctcggttgtc ggcgagtcgt tcaccctcga cgtggccggc tcgctggatg ccgtggaagt
     7741 cgccgtacag cacgggtttc tggtcgaggt cgcggctcag gagttccggt tctcgcacgc
     7801 cttggtccgt gacacgctct accaggacct ttcgcagacc cgccgggctc atttgcacct
     7861 cgcggtcggc tcggcccttg aacgggtccg gcccgatgac gttgccgcct tggcacacca
     7921 cttttcactg gcctcggacc cgcgagcggc tggatatgcg cgtgcggctg cttctttggc
     7981 cgaggcgcgt ttcgacttcg gtgaggccgc tcgcctgtgg cgcatcgctc ttgccagtgc
     8041 ctcggcggat cggcttgagc tgatcatggg cttggtccgt gccttgtcgt tcaccggatc
     8101 gctcgggcag gcccgggaac ttcgggcttc ggcgctcgac ttgctcggcc cggtcgacga
     8161 tccagagttg gccgcgcggg tgatcgcgtc tttcgacgta cccgcgatct ggacaacgcc
     8221 ggacgatccc gccttggcag ctcgcgttgt cgctgtgact gagcgagttc tgccttcggt
     8281 gacgtctgct tcccgtagcc gtctgctggc cacgatcgcc atggaactac gcagctcagg
     8341 cggtcatcgc gcggttgcag cggcgtcgga ggccgtggcg atcgctcgga ccctggacga
     8401 tcccgcggtg ttggcgttcg ccctgaacgc ccagttcatg cagtccttct cccgggcagg
     8461 gcttgccccg cagcgagtgc gcatcggtac tgagctcgtc gatgtggctt cacggaattc
     8521 gctggtgacg ttcgaggtcc tcggccacat gatcctgatg caggcacact cggcgcttgc
     8581 tgcgttcgcc gaagcggaca cccatgccgc cgaggtcacc cggctggggc gtgactatca
     8641 gttgccactg gccgaggtct tcgttcagtg gtatcgggcg cttcgcactt cggtggccgg
     8701 cggagatgcc gcgcctttgt accgcgcggc tttcctggca ggcaccgaga tgcctggcct
     8761 cggtgacggc atcctgtcgt tcgccttgct gtgtcatcag ctccgcaacg ggctgcccgt
     8821 gtcccgtgac ctggacttcg gcgtctacga gccttggtgc cgacctggcg gcgtgattcc
     8881 gccttcacca cacgacctgc tgttcgaggc ccggacttgc ctgcacgcga tcgccgctgt
     8941 cgaaagaggc gatcgtgagt cgatggccga gctctacgac gtgctgctgc cagctgctgg
     9001 ggagctcgcc ggggccggaa gcgggctgct cacgctgaag ccggtcgcgt actacctcgg
     9061 cggactggct cgaggcctgg gacgtcaccg cgaggctgct cagcacgaca agcaagctgc
     9121 tgcgttggct acaccgtgat cactgtgccg tcgaagggcg cttgcgctcc cgcggccagg
     9181 acctctttgt attccttcga ctccgggtcg aggatcgggt tggtgttgtt gagatgcgtg
     9241 tagatccagc gcttgcctgg gtgccgggcg atctgggcga ggctaccctc cggaccggcg
     9301 atcgggatgt ggcccatcgc ccgttgcgcg cctgatccca cgcctttgtt cgtggcgccc
     9361 gacatctcgt cgggcgagta gaacgtgccg tccaggatca cgcaggacgc gtccgcgatc
     9421 agctcgtcga agccctcggg ccatgtcttc aagcacggcg cgtacaccac ggctccgccg
     9481 gacggatccg agatcttgta cgcgaccacc cacggaccat ccactgtgga ctggacgtac
     9541 ttgggcttct tgtcgctgat cgggaagacc gtgacggtca acccgtcgat ctcgaaattc
     9601 ccggcggctg gccgccagtt ccatgcgcca taacgagaga cgatttcctg caacggaaaa
     9661 tccgtgcgca aggcgtgcaa gacagcagca ggagcccaca ccgaaaggcc tgcgccctca
     9721 cgcagcatgg tcaggccaag ggagtggtcg agttccgcgt ctgtcagcaa cgcgccacgc
     9781 aaaggcgtgt cgcgcgggcc tggacctgcg gccaacgcgg gcgtcgaaag gatctgcgtg
     9841 cggatgtccg gcgaggcgtt gaccaggtac cagccggtgc cgtccgcact gatcgcgatg
     9901 cagtcctggg tccgggcagg cagacccgcc tcacacatcc ggcaggcgca gttccactgc
     9961 gggaatccgc cgcccgcggc cgttcccagc agcagaacct tcaactggag accaccttga
    10021 tcgtgttctt gcgcatcacg agctccggcg gctcggatgg cgtgccggcc aggatcgtat
    10081 cgatcacgcc acggtccggg gacttcgagc agaccgggtc cgtcgcgccc gcgtcaccgg
    10141 tcagcaggaa cgcctggcag cggcagccgc cgaagtcgat gcccttgcgt gaacagctgc
    10201 ggcacgggtc gggcatccag tggtcgccgc gataggcgtt gaacgactcc gagcggtacc
    10261 agatttcttc cagcgactgg gaacggacgt tgtccagctt caacgtggtg atcgacgacg
    10321 ccgccgggca ggggagcacg tcaccgttcg gtgccactgt cagctgccgc gaaccccagc
    10381 cgtacataca gggtttggga tacggctcgt agtaatccgc gaccacgtag acgatctgca
    10441 tggtgtcgcg cagtcgttcg attgccgcgc gcacgatcgg ctccgcctcg gcgagctgtt
    10501 cggccgttgg catcagggcg gaccggttgc gcaggcccca gccgtagtac tgcgtgttcg
    10561 ccagttccag gcggtccgcg cccatttctt cggccagcgc gatcaggtcc gcgacctggt
    10621 ggtggtttgc gcgatgcagg accacgttca cggtcagcgg catgtcgagt ttcttcaccg
    10681 cgcgcgccgc ggcgagtttg tgggcatggg ctttgacgcc ggcgattcgg ttggccatct
    10741 cggcgtcggc gccttgcacg gacagctgga cgtgggccaa accgcggtcg accaagtcgg
    10801 tcagccgttc ctcggtcagg ccgagcccgc tggtcaccag gttcacataa catccgaggt
    10861 ctgatgctcg ctcgaccaga accggcaaat cggggcgtgc caacggttcc ccgccggaca
    10921 tatgcacctg cagcacaccg agctcgcgcg cctggtcgat caccgacagc cattcgtccg
    10981 tcgacagctc gttttccctg gtcaccagct cgatcgggtt ggagcagtac gggcagtgca
    11041 gcgggcatcg atgggtcagc tcggcgagca tgcccaaggg cggctgcgcg atcacttcca
    11101 ctcgacaacc cgccgttctt ccaaccgttt cagcacgttc tgtacgtcgt cggcccggac
    11161 accgtcgtaa ttcttgccca gctcagcggt gatctgcgcg accgtggcgg tcccgtcgca
    11221 gagcttgagc accgcggccg cggtctggtt gggcaccaga acaccttcag ggaacagcag
    11281 aacgtgcgtt tcacgggtct tgtcgtacgt gagccgaacg ccacggcgga gccgcggcgc
    11341 ggagtccagc ccgatcatcg tcatcggcta ctccttcttc gcggcctgct cgatggcgtc
    11401 caacatggac cataggacgt tgcacttgaa ggacaacgcc gcgatggctt tctcttgctc
    11461 agcacgggtt ttgcagtact cgaccacgat gtccacagtg gcctgtcctt cgccggagac
    11521 cacgtcgatc cggttggtga agtacgcgag gtcctcccgg cggatccatg cgtagttcga
    11581 cagcatgtcg gtgacgcgct ggcgcatcag gtgaccggag aacatctcgg tcagaccgga
    11641 cgcgaccgcc tcgacccatg gcttggtgcg tgcgaacgtc acgtacgcgt cgacggcgaa
    11701 ccggacaccg ggtgcgacgt gtcgctcatc aagaacttct tccctggtaa ggccgactgc
    11761 ctcgcacagt cgcaaccacc gctcgcggcc gccttcgcct tccgctgtgc cgtcgtggta
    11821 cacgatcctg gccagccagt cgcggcggat ccgcggaacg gggcagttgc tgatgatcgc
    11881 cgcgtccttc tgcggcaaca tgcattggta gtaccaccgg ttcgcagccc acgtgcgcag
    11941 ctcgaattcc gagaggctgc cgtcgtgcag tctgcggtgg aacggatgtg ttccccagta
    12001 acggtgggaa aggccacgca actggccgac gaactcgtcg gcaggcagca gagtgttcga
    12061 agtggacggt gagatcgaca cagtcgactc ctccatgcag ggaaacggag aggtggcgag
    12121 ggccgtggta gggcttcggc cctcgcgcaa cggatgtgcc tcagtcgtcc atccgggccg
    12181 cgtaggccgt gacctccatc ggcgtttcgt attcgacgaa gtccggagtg gtccagacct
    12241 cgcgctccgt gttttcgatc atctctgcac tcctcggatc agtgacggtc ctggtggatc
    12301 gtcctggcaa aggacctgtg tcgagcatca cgactgtagg agctgaatgg tttagaaagc
    12361 tagcccccta tgttttctgt ggcgcgcgga cactccgatc cctgtcaacg ggacatcatc
    12421 tgtctacctt gttaccgatt gtgacgacaa tggtcggagg tctgggccct tgttagctca
    12481 gtcggtggta ggacgatcga caccctgtgt gtttgtatgc actcgccgcc gtgtgaagcc
    12541 caagggatgc tccaggaggc aaacccatga catttcgtcg caaactcgct gtcgctgccg
    12601 cgtcggcgac gaccgtgatg ctggccgcgg gcaccgcgac agccgcgccc gcggacgtgc
    12661 aaccgttggc gatcaagcaa gtcgcgagtg gactcaacca ggcctgggca gtggatttcc
    12721 tgcctgacgg cacggctttg ttcaccgaga aggactcgcg caagatccgg aagatcgcgc
    12781 cgaacggcca ggtgtcggac gttcagacga tctcgggggt cagcgtcacc aaggaagcgg
    12841 gtctgctcgg catcgcggtg tccccgacgt acgcgaccga ccagctcgtc ttcatctact
    12901 acacaacgag ttcggacaac cggatcgcga aactcaagct gggccaggca ccgaccccga
    12961 tcgtgaccgg aattccccgt ggctcgcagt accaccacgg cggccggatc aagttcggcc
    13021 cggacggcta cctgtacgcc ggaaccggtg acgggcagaa cggcgccaac gcccagaacc
    13081 gcaattcgct gggcggaaag gtgcttcgcg tcgacaagaa cggcgcggcc gccccaggaa
    13141 acccgttcaa cagccgggtc tactcactgg gacaccgcaa cgtgcagggc cttgcctggg
    13201 tcggaaccca gctgtacatc tcggacatcg gtgccagcaa ggtggacgag ctgaacaaga
    13261 tcacgcccgg cgggaactac ggctggccga gctgtgaagg cccgtgcagc aacccggcgt
    13321 acaccaaccc ggtcaagaca tggccgacct cccaggcaac gccaagcggc ctgacgtact
    13381 acaagggcag cctgttcatg gcctcgctca agggcggcac gttcaagctg aacaccagcg
    13441 gtgcgggcgg caagctctac accaacctgg gccgcacacg ggacgaggtc gcagggccga
    13501 acaacgtgct gtgggtcgtg acgcctggcg gcatctacaa cgctgacggc tcgtgagaac
    13561 cggggtggct tcgccttccc tgcacgggcg aagccacccc ttacccgagg gtccactgtg
    13621 ggggttcaca gacatatttg tgagcggtgt ctcagttacg cgtcttgatc gtcggcgcca
    13681 acggttggcc gacgcgttcg ccagcgcaaa gcacgtactc ctgatcggca ggccacgaac
    13741 tgcccgaaat caccccttgt ccgcccatcc gcgacccctg atcccacctt cggcccgcat
    13801 cacaccggga ggggcgtcga ggttgcgaac ccgcgccgtt tagacttgcc gacaagggga
    13861 cacgaaggag aagcgcgtgg ccgagatttc cgttgaactt gtcgccgtcg agcgccggct
    13921 ctggtcgggc aaagcgacga tggtcatcgc acagaccacc gagggcgaac tcggtgtgat
    13981 gcccggccac gaaccgctgc tcggccagct cgtcgagggt ggtgtcgtca aggtccgcac
    14041 cacggacggc gagaccgtca tcgcggccgt gtacggcggc ttcctgtcca tcaccggcga
    14101 cggcgtgagc atcctcgcgg agaacgccga gctcgccgag gagatcgaca tcgaccaggc
    14161 gcgggctgac gtagccgcgg cacaggacgc ggacgagcgg gcaagagcag aagcccgggt
    14221 tcgcgccgcc ggacagacgg tctgatccgc gggactgggc gggggcggcc gtggagatcc
    14281 tctggttcat cgggacgctc ctggcggtcg cggccgccac attgctcttg ctcggcatcc
    14341 gccgggtcag actgatccgg atgggcggca tcaacgtcgc cctgcggacg cacctggaca
    14401 atccacgagg ctggcacctc ggagtcgcgc ggtatcacgg tgacgagttc acctggtacc
    14461 gcgcgttgag tttgcgcaac ggcccgaacc ggatcatcca gcgcgacggc ttcgagatcg
    14521 acgaccggcg cgagccagaa gcccaggagc tctacggcgt gccgaacggc gccatcatcc
    14581 tgcggtgccg cgccgagctg gacccgccgc gttccaagcg ggctttcggc ggcccggaca
    14641 ccgtcgtcga gatcgcgatg accccggacg cgctgaccgg cttcctctcc tggctcgaat
    14701 cagcgccccc aggtcgtcgt cttccttacg cctcctaggc cagatccagc ttgacgacca
    14761 gcgcgtccag gttcggcgtt gttgagccgc cagcgggctc aaccgtgatc gcgagagcca
    14821 ccgcaccttg cgcgggcctc aagtcattcg atgaaatggc gccgttgggg accggcagag
    14881 ttccagccga cgtctggcca ccagcattca ggtggcggac gtaccagagc tgatacacgg
    14941 aggtccccgg cagcgctggc gcgcccttga gcgtcatcac catgccgttc tggctcggcg
    15001 aaaccactgc tgtcgccgtc ccgccacctt tgacagggcc tgtgacgatc ttcgcgtccg
    15061 gcgcgctcaa cagcgtctgc agccgggaca actcggtctg cgtctgcgcg agctcgtcct
    15121 tcacgtcgtt gttcgtcacg acccagccca cgccaagtcc tgccgccaca aggaggctcg
    15181 cggccgcggc gaacaccgcg aaacgagaac tcccgcgtct cgggcgaagt ctctgcggct
    15241 cgtcgaacga catcggcggg agctgcctga cgttcccgat cgccgcgtgc accttgtgcc
    15301 acagctgcgg cgggggagct gccgcggttg ctgtgccaag gcgtgcggtc gtttcccgca
    15361 gctcggcgac ttcctggtgg cacgcggggc agccggacat gtggtcctcg aacgccctgc
    15421 gctccatttc ggacagcgcg tccagcacgt acgcacctgt cagtgtgtgt acatcgttgt
    15481 tcacgccgtc acccccatgc agtcacgcag cctgatcagc ccgtcccgca atcgtgtttt
    15541 gactgtgcca aggggtgagt caagcaaatg cgcgacttcc cggtaggtgt agccctggta
    15601 gtacgcgagc atgaccgact cgcgttgcag ttcggtgagt gtgccgagac atcggcgcac
    15661 ttgttcgcgt tccatccggc ctgccacgac ttcggtgact tcatcgaacg gacgcgcggt
    15721 ttcggcacga gccacgcgtg aatcgcggtc ggtgctcgcc tgcgcggagc gcacgcggtc
    15781 gacggatttg cggtgcgcga tcgtcatcgc ccacgacaac acggaaccac gttccgggct
    15841 gtagcgagtg gctgagcgcc agagctcgag gaagacttcc tgcgcgacct cttccgactg
    15901 cgctggatcc cgcaggatcc gctgcacgag cccgaaaatc ggggccgaga ggtggcggta
    15961 gagctgttcg aacgcggttt cgtcgccacg cgccacgcgg ggcagcagtt cgtcgagggt
    16021 ggccggcctc ggtcccccgg gctcccgtga ccgctgcgcc cgttcccgca tgctcacccc
    16081 tcctcgtacc tcagcctgcc cgccaggtat tcgctcccgg cgtacaagcg gattggtaga
    16141 agaggttagt ggtttgtttt ggcgccgcgg gagcgactca gtcgagtcac ccctgcggca
    16201 agtcgtactc ccagttcacg gatgaaggct cgagggcccg agctgccttc gcgcggcagc
    16261 acggctggac tcacgcggac gcggacagcc atttcgacct gccaggacgg gccggaaccc
    16321 agcacccgtt gaccttcggg acgtcaccgg gctcgggatc cggcagggcg agcaattctg
    16381 cgacgaccgc ggccgacgtg ccgctggagc gccagaaaac cttgtaggga aagaagatgt
    16441 ccatctcgtc acccgggatg cgggtggcgt cggcgtcgtg ttcgccgtag atctgcacca
    16501 cgtcgaccac gccgtggtgc acgcgcacac cgacgacagc ggccacctcc cccgtggcgt
    16561 cgcgcgggtg cgcgaagctg aacccgcgcg cgatcagctc cttgagctgg gcttcgaagt
    16621 catccatgtc gccacctttg tcacaacagg acgtcgtcga attcgccgtc cttcgcccca
    16681 gcgaggaagg cagccatctc agcccgggtg tagatcagtg cgggtccgtc agggaaccgc
    16741 gagttgcgga ccgcgatctc gccagactcg agcgtcgcga cttcgacaca gttaccgacc
    16801 gcgccgctca tccggctgcg tcgccaatcg acgccgccga ggcggtccgc ggaaaccccg
    16861 ttgtgtactg ccgtcatgga gtgctcccac cttttccccg acttgccttg gcggcggcac
    16921 gtctggatct tcgtgcataa gcaaggtagc acggccggtt gcccgtgcgc atgcacgtgc
    16981 atctgcacga atttcacagt tggtggcgtg ggcagtgatc ttgacgagtt ttgtcgacag
    17041 ggagtagttc ctggtcgctc agggtgagat cgattgcact cctacgcccg cgtagggccc
    17101 gattcgtgcc acacataacc ctcgcgaggg ggaaaatgtg atgactgtcg ggcgtgtcgc
    17161 gagtggacag cgggccgtga tcatcgggtg tttgcccgat tgggcaaacg ggtgcccgca
    17221 acccctgacg ggttaagacc agataacgaa tcgaacgaac ggtccgttcg cgaatctggt
    17281 tgtccacagc ccctcagaaa ccctttgacc agcccatatc cccgatagac tggcctgggg
    17341 tcgtcccccc gggagtggtg ggggatgccc tttggttggg ggtgggggtc gttgatgtcg
    17401 gttgctgcag cgcgatgagg tctttcctgg cgtggagggt tctggtgcgg ctgcacagtg
    17461 gtcggcttcg ttggggcttt gctgaccacg gggtgccggg aggttggttt tcgacaacaa
    17521 ccctgagtcg agtccgctcg ccacgcccgc aaggcaagga caagccgggc tttgacggag
    17581 tcctgctggg agtggtgggg gatgtcctgg gttggggcgg gctgcctggt ggtgatgggt
    17641 ctggtcgcgg ttgggacccg aagcgttgtt acagcgactt gaggaccttc gagatggtcc
    17701 ggcgcgtctg ctcgggtgtc tccgcttcga caaccagccg atgtgcggct ttgttgtaga
    17761 cctcgacctc gtcggtcttg tccaggtaga gcgcgccgca caggtgctcg aggtagacga
    17821 tgtccggaag ttccggttcg gcgaaccgca gcagggtgaa cggcgtctcc gcggccgacc
    17881 cgcccagctc gaacggcagg atctgcagcg agatgttgga catcttggtc aggtcgagca
    17941 ggtgctccaa ctggtcgcgc agtaccttgc ggccgcccat ttgccggtgg atgcacgctt
    18001 cctcgacgac cgcccacagt cgaggcgcct gcggcgaagc cagcaaccgc tgccgctgca
    18061 tccgcaggtt gacgcgccgg tcgatctcct ctggcggcgc gtccggtctg cctcgcagca
    18121 tcaccgcgcg ggcgtagtcc tcggtctgca gcaggccagg gatgaactgc acctcgtacg
    18181 tctggatccg ggacgccgac tcctcgaggc cgacgaagtc ctggaaccag tgcggcatca
    18241 gatcgttgta gcgctgccac cagcccggct ggttcgactc gcggaccagg gcgaggaaga
    18301 tgtcccggtc gctctggtcg gtcacgccgt agagcgtcag caggtccgcg acatcgcgtt
    18361 ccttgaagct cacgcggccc agttcgaccc ggctgatctt cgagccggaa ccacggatcg
    18421 cgtagccggc gtcttcgcgg ctgatgccct tcgcctcacg cagccgacgc aactggctgc
    18481 ccaggaccat tcggcgcgcg gtgggaccac tacctgcggg ctcacccgtg ggcatggtca
    18541 cctcctactc gcccctgctg ctcgcagcca cacactctaa gaccaaaagg aacacaaagc
    18601 gcggatgtcc tcgctaattg gttcccgcac cacccggttg ccacaggacg tcaccgtccg
    18661 ggttggccag gcgacagagg atgaacagca ggtcggagag gcggttgagg tacttggcgg
    18721 cgagtacgtt cgttcggtcg gcgtctgctt cgatcaatgc ccacgtcgcg cgttcggccc
    18781 gtcgcgttac ggtccgggcg acatgcaggt aggccgcgcc gggcgtaccg ccgggcagga
    18841 tgaaggacgt cagcttgggc aggcgctcgt tgaactcgtc gcaccagttc tcgagccggg
    18901 tgatgtagtc cgaggtgatc cgcagcggcg ggtacttcgg gtcctcgacg atcgggttgc
    18961 acaggtccgc gcccacgtcg aacatgtcgt tctgcacggc ccgcagcacg gtgacgatct
    19021 cgtcgggcag gttgccggtc gcgacgacga caccgatggc cgcgttggct tcgtcgacgt
    19081 cggcgtacgc ggcaagccgc gggtcggttt tggacacgcg ggagaagtcg ccgagtcccg
    19141 tcgtgccgtc gtcgccgact cgggtgtaga tgcgggtgag gtgcacggcc atgccctgaa
    19201 ccttatgtga cggaggcata gcaggtcagc gggcgcgcga tgtcgcttat gcgtggaata
    19261 ccgggcgctg tcatatacca ctttctttct gcgtcacgcg gcttggatga cgatcggact
    19321 aaatactggt ccttaacttt cccagcccct aaagtgatct gggtcaactg tccaatgggc
    19381 tatgttcgat gctcggctgc gcagggagcg ttggactttg agaacaagtg ctagcgatgg
    19441 gccgtccctg agactgagcc tcgacctggc gccagctggg ccgatgaaag tcaagtcggc
    19501 tgccgaacag ctggttgacc ggctgatcac ggcgatcgcg ctcggcgcgt tgctgccggg
    19561 gcaaaagctg ccgccggaac gggaattcgc cgcccggctc aacgtcagcc gtaccactct
    19621 gcgggacgct ctgcaccaac tcgaatcgct tggctatgtc gggatcacgc gcggccgcag
    19681 cggcggagtg cgcgtgcata gcacatgggg accggaatcc gggtcgcata ttcggagcat
    19741 gctgttgcct cgatggcaac acctcacatg gttgttcgac ctgacccggt cattgctgcc
    19801 gatgatcgcc ggattggcgg ccgaacggcg tactgacgaa cacatccgca agatctgggc
    19861 ggcagtcgag gcgtacgaaa aagccgaaga ccgtgatgtc atgcggaccg cggaccacac
    19921 gttgcattcc gcggtcgccg aggcaaccgg caacccttat tacgtgagca tcgactcgca
    19981 gctgcgtatc cagctcacgt tcggcactga ttccctgccc tatgacaccg agatcaggca
    20041 acgcgcgctc gacgaccacc gcgcgatcgc cgaagccatc gaggcaggcg acagcgcacg
    20101 ggccgccgac ttgaccatgc accacttcgt tgagctcgcc gagaagccga tgttgcgcct
    20161 gcggcaacgg gttgaggcag cgggagcctc cgaatccgag tgaccaaacg gacagccgta
    20221 cgattggcgc tcatccaagg gtcattcatc gggagggtgc gtgtctgagc acttccgggt
    20281 tcacggcggc gcgagactcg tcggcgaggt cgacgtcgtc ggtgccaaga acagtgtgct
    20341 caagctgatg gcggcggcgt tgctcgccga gggcacgacc acgctgacca actgcccgca
    20401 gatccttgac gtgccgtaca tggcggacgt cctgcgcagc atcggctgcg aggtgagcgt
    20461 cgacggcgac acggtcgtca tcacgacgcc gtcggagctg aaccacaagc cggacgcggc
    20521 ttccatgggc aaactgcgtg cttcggtgtg cgtgctcggg ccgcttgtgg gccgttgccg
    20581 ccgtgctgtg gtcgcgttgc cgggcggtga cgcaatcggg tcacgtccgc tggacatgca
    20641 ccagaacggc ctgcgtcagc tcggcgccac tagtgagatc gagcacggtt cggtcgtcgc
    20701 cgaggcggaa ggcctgcacg gcgcccagat ctggctggat ttcccgagca tgggcgcgac
    20761 cgagaacatc ctgatggccg cggtcctcgc ggacggcacc acggtgatcg acaacgccgc
    20821 acgcgaaccg gagatcgtcg acctctgcac gatgctccag cagatgggcg ccaagatcga
    20881 aggcgcgggc acgtccacgc tcaccgtgca cggcgtcgag acgctgcagc cgaccgagca
    20941 ccgcgtgatc ggcgaccgga ttgtcggtgc gacctgggca ttcgccgccg ccgtcacccg
    21001 cggcgacctg accgtccgtg gtgtcgaccc gcaccacctc gacctggtcc tcgacaagct
    21061 gcgcacggcc ggtgccgagg tcacggtgta cgacgacaag gccttccgcg tcgtgatggc
    21121 cgagcggccg aagtccgtgg acttcgtgac gctgccctac ccggggttcg ccacggacct
    21181 gcagccgttc gcgatcgcgc tctgcgcggt ctccgaaggc accgcgatga tcaccgagaa
    21241 cctcttcgag gcccggttcc ggttcgtcga ggagatgatg cggctcggcg cggacgcacg
    21301 gacggacggg caccacgcgg tcatccgtgg cgtggagaag ctgtcgagcg cgccggtttg
    21361 ggcgtcggac atccgcgcgg gcgctggtct cgtgctcgcg ggactgtgcg cggatggcgt
    21421 gacggaggtg tgggacgtgt tccacatcga ccgcggctac cctggtttcg tggagaacct
    21481 cgtgcggctc ggcgcgaacg tggagcgtgt cacgcaagcg cccgagcggt agaccttgag
    21541 cggtagacgc ggagcgccca agcggtagac gccgccgccc gcacgccttc cgatctcggc
    21601 aacgagcagg gtggccattc agttccaacg cggacacggc tggcactgag tgccaactca
    21661 gtgccagccg acgcgccgaa gctggaccgg ctcctcagcg ccaacagcca atggatcagc
    21721 gccaacagcc aatggacagg tcttccacag gcggcacata actcgtggcg tgagcatggt
    21781 gtccatgacc gaacccgaac tgacttacga gggccgccgc ctgccccgcc cccacgacga
    21841 agtggtggac caaggcctcg gcttcgacat cgccacgctg ttcgaccgcc gacgtgcgct
    21901 tcgtctgctc gggcttggcg ccgcaggcgc ggccgtggcc gcgtgcagtc ccagcacacc
    21961 acccagtacc agcacgccga cgtccaccgc tcccaccaca ggcgcgacgt cgggctcagc
    22021 cgctccggcc gcgttgagtg aaatcccgga ggagacggca gggccgtatc ccggtgatgg
    22081 c
//
