LOCUS       NZ_FWXV01000002        25124 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Kibdelosporangium aridum strain DSM 43828, whole genome shotgun
            sequence.
ACCESSION   NZ_FWXV01000002
VERSION     NZ_FWXV01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kibdelosporangium aridum
  ORGANISM  Kibdelosporangium aridum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Kibdelosporangium.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900176515.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:02:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,283
            CDSs (total)                      :: 11,193
            Genes (coding)                    :: 11,032
            CDSs (with protein)               :: 11,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 3, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 38 of 161
            Pseudo Genes (incomplete)         :: 135 of 161
            Pseudo Genes (internal stop)      :: 6 of 161
            Pseudo Genes (multiple problems)  :: 17 of 161
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:58:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1929144
            Orig. end                         :: 1954268
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FWXV01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25124
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="terpene"
                     /product="ectoine"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..25124
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /detection_rules="ectoine_synt"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="ectoine"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..21527
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21527
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11527](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11527
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(401..2938)
                     /gene="otsB"
                     /locus_tag="B9C43_RS18755"
                     /old_locus_tag="SAMN05661093_03820"
     CDS             complement(401..2938)
                     /EC_number="3.1.3.12"
                     /GO_function="GO:0004805 - trehalose-phosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="otsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018682468.1"
                     /locus_tag="B9C43_RS18755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03820"
                     /product="trehalose-phosphatase"
                     /protein_id="WP_084427876.1"
                     /transl_table=11
                     /translation="MTAEALPAELRRAIVQLARTPRLLVACDYDGTLAPIVEDPEKARP
                     QPESVHALRSLAGLHETTTAVISGRALRDLATMSRLPAEVHLVGSHGSEFDIGFVHSLN
                     GPARELHTKIEAELERLVDGAEGVHLEVKPASIAVHYRRAEQSIADRIAEAVRTGPCTW
                     EGVQVTEGKAVIELAVVQTDKGHALDVLRHQMGATAAIFVGDDVTDEKAFARLSGPDLG
                     VKVGGGETLAQFRIDDTPAVAAMLAFLLEERRNWLYGEQATPIERLTMLANERSVALLT
                     PEARVTWLCHPEPDSAAVFADLLGGPSAGHLSITPERGGLPLGQRYLPGTMTVETRWSG
                     LLVTDYLEHYAQPHRTDLIRTITGSSRAIVEFAPRPEFGQVPVKLVRNENGLRVVGTSD
                     PMALHSPGVDWEITSDGMHDTARAIVSPNGEPVLLELRCGTDDLAPDPIPEPERKNRAN
                     RYWTEWLGSLRFPEVERELVIRSALTLRGLCHSETGGIMAAATTSLPEEIGGIRNWDYR
                     YCWLRDGALTAKALVSLGSTAEAEAFLNWVHGVLATVPGPERLHPLYTLAGTGLGPEAV
                     IDTLPGYAGSRPVRVGNLANQQVQLDVFGPVVDLVAALSLARGKLTDDDWKMTNAMAEA
                     VARRWEEPDHGIWEERHRPRHHVYSKVMCWLTIDRAITLAETYGRQPNPEWHALRDKIA
                     TDILTKGWNDEVKSFTTAYDGTDLDAASLFVGLSGLLDPSDERFASTVTAIEAELRSGS
                     TVYRYHRDDGLPGNEGGFHLCAAWMIEAYLMCGRRTEAEDLFAQMVDCAGPTGLLPEEY
                     DPIAERSLGNHPQAYSHLGLIRCAQLLSGEKPV"
     gene            complement(3006..4430)
                     /locus_tag="B9C43_RS18760"
                     /old_locus_tag="SAMN05661093_03821"
     CDS             complement(3006..4430)
                     /EC_number="2.4.1.15"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787776.1"
                     /locus_tag="B9C43_RS18760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03821"
                     /product="trehalose-6-phosphate synthase"
                     /protein_id="WP_235038678.1"
                     /transl_table=11
                     /translation="MNSGADFIVVANRLPVDLERAEDGTQRWKHSPGGLVSALEPFLRS
                     KSGAWVGWPGVPDVDVEEFEDDGLRLIPVTLSAADVRDYYEGFSNATLWPLYHDVVEPP
                     VFDRAWWDSYVKVNHRFAEATAAVASPGATVWVQDYQLQLVPQLLREQRPDLRIGFFLH
                     IPFPPVELFMQLPWRTEIVRGLLGADLVGFHRPGGAQNFLWLARRLVGLEPSRAAVGVR
                     TRPGLIHVGDRPVRVGAFPISIDSAGLDGMARKRDTIQRAQQIRTDLGNPKKILLGVDR
                     LDYTKGIDVRLHALQELLIEGRVDPDEVTMVQLATPSRERVEHYQRMRQGIEQVVSRIN
                     GEFGKVGHPVVHYLHQSVDRRELVAFFSAADVMVVTPVRDGMNLVCKEYVACRHDLGGT
                     LVLSEFAGAAAELTSAFLVNPHDLDGVKNALHAALTIDPAEGRRRMRALRRQVLTHDVD
                     RWARSFLEALGSQGLN"
     gene            complement(4522..5901)
                     /locus_tag="B9C43_RS18765"
                     /old_locus_tag="SAMN05661093_03822"
     CDS             complement(4522..5901)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018682470.1"
                     /locus_tag="B9C43_RS18765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03822"
                     /product="threonine/serine exporter family protein"
                     /protein_id="WP_084427878.1"
                     /transl_table=11
                     /translation="MPRGKRGTGGVVVAQFVPAESVVNQVLDLALRIGEVQLSSGAGAS
                     DVTATIIAVANACGLEQCQVDVTFTSITACCHRGAEFAPVTSLRVVRSRGLDYTRLAAV
                     EQLVRDITRRRTTATEAARRLDRIVNARHPYPRWVATAAWAGMAASVTVLLGGGPLVAL
                     AAAVITAVIDRIGRILNRHNLPFFFQQVLGGALATGGALAVVSTGWLGESPTLVVAAAI
                     TVLLSGLSVVGTVQDAITGYNVTAAGRAMEVALMTAGLIGGVVLALNMASELGLPRVPM
                     AEALPPTALRLPLQTVAGAAAAGCFALASYATMRSMMVASAAGALGALGYGGLVLGGAG
                     PIVASAVAAAGIGFCGGVMARRLGVTPLVVAVSGMTPLFPGLTTYRSLYELAVDGTSAG
                     VVTLMTALGIALALGAGVVLGEYLAQPVRVSLGRLERRLGAIRLVGPTWQRLELETTAS
                     K"
     tRNA            complement(6110..6182)
                     /anticodon=(pos:complement(1935291..1935293),aa:Thr,
                     seq:tgt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="B9C43_RS18770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SAMN05661093_03823"
                     /product="tRNA-Thr"
     gene            complement(6110..6182)
                     /locus_tag="B9C43_RS18770"
                     /old_locus_tag="SAMN05661093_03823"
     misc_feature    complement(6133..6150)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.95"
                     /tool="antismash"
     gene            complement(6241..6876)
                     /locus_tag="B9C43_RS18775"
                     /old_locus_tag="SAMN05661093_03824"
     CDS             complement(6241..6876)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9C43_RS18775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05661093_03824"
                     /product="hypothetical protein"
                     /protein_id="WP_084427880.1"
                     /transl_table=11
                     /translation="MITRKLDPWQQALLRELRTRDLSSERIEQLLDSVEAYCADTGKTP
                     QQAFGDPASYARVFAPGLQPVKFVPAAIQGTLGIAGLVILASGVPAVMNELPTAVIRTG
                     AVVSFGAALVVFIAFLAVKRHLVISAGALSLGIVALVVPYFLWPTTFVEIPVWPAVTGS
                     LFLMSAAWAVSVYPDHVLDRDTKQRQINTMRWCLPTLMACGALLSWLR"
     misc_feature    complement(6826..6828)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6917..8266)
                     /locus_tag="B9C43_RS58505"
                     /old_locus_tag="SAMN05661093_03825"
     CDS             complement(6917..8266)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013717.5"
                     /locus_tag="B9C43_RS58505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03825"
                     /product="molybdopterin dinucleotide binding
                     domain-containing protein"
                     /protein_id="WP_235038680.1"
                     /transl_table=11
                     /translation="MSILEDLGVQQAPHSTLSSYLEKLLWALTGNFAKQGAVNTHSWLV
                     PVAKHDPRRDRRTPVTNTPMFANLVPCNVIPDEILTDHPKRFRAMIVESANPVHSLADS
                     PRMREALDALDLVVVIDVAMTETARHAHYVLPAASQFEKWEATFFNLEFPRNTFHLRAP
                     VLDPLPGTLNEAEIYARLIRALGLVTAEDLAPLHEAETREAFAQAMLRAMSGKLAPLAP
                     FVLYETLGPKLPNGARNAAVLWLAAQKCAMTYPDAVKRAGHADGEALFEAILNSRSGIT
                     LTLDEYADAWRYVGTDDGRIHLAIPSLLDEIRKLDTTQAWTSDEFPFVLSAGERRSFTA
                     NTILRDPAWRRRDTRGALRISPQDAEALGLQDDGTAIVTTTRGSVEAAVEINDRMQPGH
                     VSLPNGLGLNYDNKLTGTAPNELTDSNWRDPIAGTPWHKHVPAKIERLTA"
     gene            complement(8309..9121)
                     /locus_tag="B9C43_RS58510"
                     /old_locus_tag="SAMN05661093_03826"
     CDS             complement(8309..9121)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012602.5"
                     /locus_tag="B9C43_RS58510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03826"
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_235038681.1"
                     /transl_table=11
                     /translation="MDQWHKSVCILCACNCGIEVLTEDRLFKRIRGDKDHVASAGYTCN
                     KALRLDHYQNASDRLTSPLRRKDNGEFEEISWDTAIAEIAERLKAVRDAHGGESIFFYG
                     GGGQGNHLGGAYSAALMRGLRAWHRSNALAQEKTGEFWVDAQLHRGHTAPDFEHAEVSV
                     FVGKNPWQSHGFPRARVVLKEIARDPARSLIVIDPVRTETADLADIHLQVKPGTDAWCL
                     AAMVAVVVQEDLVDHTFLAEHTTDSAQVLEHMAHIKVAEYAQRCGVSE"
     gene            complement(9183..9746)
                     /locus_tag="B9C43_RS18785"
                     /old_locus_tag="SAMN05661093_03827"
     CDS             complement(9183..9746)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF047071.1"
                     /locus_tag="B9C43_RS18785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03827"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_200825569.1"
                     /transl_table=11
                     /translation="MAGDVRKAMVHSAVTLFRERGIAGTSLADVIEHSGAPRGSIYHHF
                     PGGKNQLAAEATAWAGEVMNRMIGKFDDPIELTRALFEFWRAELSENVQTSCPIVAAAL
                     GAAESVDAYRAAGEVFGKWERTIADLLVRRGVSEERAVSAATLLITSIEGATVVARARQ
                     DTRALDRVEREMTRMLGHLLVDSA"
     gene            10001..11527
                     /locus_tag="B9C43_RS18790"
                     /old_locus_tag="SAMN05661093_03828"
     CDS             10001..11527
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024640.5"
                     /locus_tag="B9C43_RS18790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03828"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_143446399.1"
                     /sec_met_domain="T2TS (E-value: 3.6e-13, bitscore: 45.6,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDRIPQGLVGTGRVPLVNLIISFDTYECFLVQLGPVGPSCPRVA
                     LAAGPGGLEQLGPGIESATKSALGLVVTYVGVMSFEVTSTAIDMYVLVSAREPATWPIG
                     TTLMTLPELVRAGADISLIGLFQAAASRAEAERFALKIGGPVRHALARTVEHLEERFTV
                     EDGRAGWSQYLSNDAVGVMSSAQGLLALAHASVASRYIEPVARCLEQAQNPDGGWQVKH
                     SLHGEPTQISITESTCYCLWALVESGRTEECIAVSSGAAWLMNTQRPSGGWGVSERSAE
                     AQVIATAFAVRMLARLGNRGAVGRGVQWLRDNQREDGSWPLDRAVVSPTEPDLSPPAPT
                     AHAVIALLSAGVPANDNAIIQGVAYLRRRFNSAGVEPWRSALSDTLVDPRTDSRLIFRH
                     YTTPWALVALSQAGASLSDPLVQRGILQLLAQQMPSGAWRCNATVPASPTMWAAHDTVF
                     ALKTVVSIGVRILQSAPVLGLTTASLESMMMSFLLTNGSPWPGAQEAMGA"
     misc_feature    10136..10138
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11893..12981
                     /locus_tag="B9C43_RS18795"
                     /old_locus_tag="SAMN05661093_03829"
     CDS             11893..12981
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038283.1"
                     /locus_tag="B9C43_RS18795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03829"
                     /product="viperin family antiviral radical SAM protein"
                     /protein_id="WP_160096563.1"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-08, bitscore: 32.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.4e-16, bitscore: 58.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSSGPPESPHVPSVNYHVWQACNMRCRFCFATFQGVRKNVLPAG
                     HLDRPDAMRIVRALARAGFTKINFAGGEPFLCPWLVDLVVYAKKLGMVTSVVTNGSYFD
                     RSVASDLLKHLDWLVLSVDSLHPATAIRIGRVKAHKPISKRQYLAICERVHAAGVNLKI
                     NTVVTSANYGEDFRDFIIRARPRRWKIMQMLPLQGPDSRCAEDLIVDRDGFNHFVAKNR
                     RVRKNGIVVVPETSSDMVGSYAMIDPAGRFYDNVSGQYKYSQPILDVGVRAAFSEVDVS
                     AARFLARDGLYDFWGGWKWRRVGSWAQLRGYLRNRWRPSAVSSATPLTTAATAEPVWLQ
                     ARISRRTDVLESGQATAVISST"
     gene            13040..13765
                     /locus_tag="B9C43_RS58515"
                     /old_locus_tag="SAMN05661093_03830"
     CDS             13040..13765
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669880.1"
                     /locus_tag="B9C43_RS58515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03830"
                     /product="Abi-alpha family protein"
                     /protein_id="WP_084427892.1"
                     /transl_table=11
                     /translation="MAEERDPVDRVVAQASRLAGWLAKTSWQAAGRLPGGEAAQRQFRK
                     AEKAVLDQVRKRLDEEGTFTGKLIEAPPAVVDGHVDPVRSAMAELLRLSTELDREQGRH
                     HLFMSIVRQLVPDEARILAALSDGEVYALVHVAGRSTLGGPQRIVLRNASSVGRAAGVM
                     LPDLVPDYVTRLLSLGVVQTGPEDQALSTQYDILLTEDRVRTAETEVRTVHKLSPRYLK
                     RTVKLSTLGTQFWDAARPG"
     gene            13762..15001
                     /locus_tag="B9C43_RS18805"
                     /old_locus_tag="SAMN05661093_03832"
                     /pseudo=""
     CDS             13762..15001
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669881.1"
                     /locus_tag="B9C43_RS18805"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03832"
                     /product="DUF445 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIDEIVADFQRNWHVYASMPLIAALIGYVTKVVAIRMMFRPIEFR
                     GIRPFFGWQGIVPRKAARMAAIACDTMTDRLISAGEVVRRLDPERGCQGVGAAAARGG"
     cand_cluster    14729..25124
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    14729..25124
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[19728:20124](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      19729..20124
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="2"
     misc_feature    14809..14811
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15097..15807
                     /locus_tag="B9C43_RS18810"
                     /old_locus_tag="SAMN05661093_03833"
     CDS             15097..15807
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012257.5"
                     /locus_tag="B9C43_RS18810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03833"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_160096565.1"
                     /transl_table=11
                     /translation="MGKIIPRRVAGGSLAYPQASLLGRLSERTREDFLAVGVSESRPAG
                     MTIISQGETDSSALLLLHGSVKVQATDPAGERTLLAIRVGGDLIGEMAALDVGPRSATV
                     IACTDIFFKRMTKAELRNFLARHPDAAIEVATMLSERLRWADRRRIEHGRPASVRVARV
                     LVDLYEAYGTRSGGHWDLSVPLTREELASIAGIKLSTAEKIIRTFQQEGLVSGRYRGIA
                     VLDMSRLRQRAEIA"
     misc_feature    15901..15919
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.24"
                     /tool="antismash"
     misc_feature    complement(15904..15917)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.25"
                     /tool="antismash"
     gene            15962..16696
                     /locus_tag="B9C43_RS18815"
                     /old_locus_tag="SAMN05661093_03834"
     CDS             15962..16696
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9C43_RS18815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05661093_03834"
                     /product="hypothetical protein"
                     /protein_id="WP_143446400.1"
                     /transl_table=11
                     /translation="MADTGFRRSLYVGVDIRGYGAAPEQRQQKWQETLLRSLDRAASSM
                     GLNRTRWSRQQHGDAELAVLPHDEPEPLVVDGFTRRLEAELRQHNEDMLPWARLRMRMA
                     VHHGVVVNGPNGYPCRDAVVVSRLLDSKPLRGVLEQWPEANLAVMLSDLVYRSVVEAGH
                     TSLRTDQFRRLAVREKEFKGYGWLWLPGCSDTIDMYARPIVSRWDSAGVQARPYVVSAD
                     EVSDVVVRGRHRTTAQRGFISG"
     gene            16760..17788
                     /gene="mgrA"
                     /locus_tag="B9C43_RS18820"
                     /old_locus_tag="SAMN05661093_03835"
     CDS             16760..17788
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0047834 - D-threo-aldose 1-dehydrogenase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="mgrA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005155093.1"
                     /locus_tag="B9C43_RS18820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03835"
                     /product="L-glyceraldehyde 3-phosphate reductase"
                     /protein_id="WP_084427898.1"
                     /transl_table=11
                     /translation="MVYQADERRYDKAEFRRSGRSGLKLPLISLGLWQNFGGARPYEHG
                     RQIARRAFDLGVTHFDLANNYGPPYGSAEENFGRILRDDLRPYRDELVISTKAGYDMWP
                     GPYGDHGSRKYLLASLDQSLGRMGLDYVDIFYSHRFDPETPLEETMGALVSAVQQGKAL
                     YAGISSYSPAKTKEAAELLKQAGVPLLIHQPSYSMLNRWIEPELLDTLEDVGAGCIAFS
                     PLAQGLLTDKYLTGVPEGSRASQHGSLQQDHLSEENLNRVRGLNGIAQQRGQSLSQLAL
                     TWVLRDPRVTSALIGVSSVEQLEQNLAALDGPPLTDAELTEIDKYAVESGLDLWRPSRV
                     AG"
     gene            17951..18457
                     /gene="ectA"
                     /locus_tag="B9C43_RS18825"
                     /old_locus_tag="SAMN05661093_03836"
     CDS             17951..18457
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018682485.1"
                     /locus_tag="B9C43_RS18825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03836"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_033392481.1"
                     /transl_table=11
                     /translation="MSGKTFGQAVVDVPSTSDGAGMWRLARDSRTLDLNSSYSYLLWCR
                     DFAGTSAVVKIDGEVIGFVTGYLRPNQPDTLVIWQITVADEHRGRGFATALLDSLVRRT
                     GARHLEATVTSDNDSSIAMFRALAARWGAGLTGNQLFSADQFPDDHAAEFLFRIGPFVP
                     VNAPS"
     gene            18482..19732
                     /gene="ectB"
                     /locus_tag="B9C43_RS18830"
                     /old_locus_tag="SAMN05661093_03837"
     CDS             18482..19732
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (22-358). E-value: 3.1e-74.
                     Score: 241.9. Matches aSDomain:
                     nrpspksdomains_B9C43_RS18830_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631928.1"
                     /locus_tag="B9C43_RS18830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03837"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_084427900.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.3e-77, bitscore:
                     257.2, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIFETLESEVRSYCRGWPTTFDKATGSLLYDETGKEYLDFFAGA
                     GSLNYGHNNPLLKRAVIDYMLADGITHSLDMHTAAKRDLLESFADIVLKPRNLDYKVMF
                     PGPAGANAVEAALKLARKVTGREAIINFTNAFHGMTLGALSVTGNSMKRSGAGIPLVHA
                     TPMPYDNYFDGQTPDFLFFERLLADSGSGLNEPAAVIVETVQGEGGINAARAEWLRGLA
                     DLCQRNGILLIVDDVQMGCGRTGPFFSFEIAGIQPDIVCLSKSIGGYGLPLALTLLKPE
                     LDVWEPGEHNGTFRGINPAFVAATEALKVYWQDDKLEKSTLAKGEQVGRALTGLVESYP
                     DVQMRAKGRGLARGLQFADAELADQVCKNAFEAGLLMETSGPDGEVVKLMPPLTISDDE
                     LEAGLSILAASVKGVLA"
     aSDomain        18548..19555
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B9C43_RS18830_Aminotran_3.1"
                     /evalue="3.10E-74"
                     /label="B9C43_RS18830_Aminotran_3.1"
                     /locus_tag="B9C43_RS18830"
                     /protein_end="358"
                     /protein_start="22"
                     /score="241.9"
                     /tool="antismash"
                     /translation="DKATGSLLYDETGKEYLDFFAGAGSLNYGHNNPLLKRAVIDYMLA
                     DGITHSLDMHTAAKRDLLESFADIVLKPRNLDYKVMFPGPAGANAVEAALKLARKVTGR
                     EAIINFTNAFHGMTLGALSVTGNSMKRSGAGIPLVHATPMPYDNYFDGQTPDFLFFERL
                     LADSGSGLNEPAAVIVETVQGEGGINAARAEWLRGLADLCQRNGILLIVDDVQMGCGRT
                     GPFFSFEIAGIQPDIVCLSKSIGGYGLPLALTLLKPELDVWEPGEHNGTFRGINPAFVA
                     ATEALKVYWQDDKLEKSTLAKGEQVGRALTGLVESYPDVQMRAKGRGLARGLQFA"
     gene            19729..20124
                     /locus_tag="B9C43_RS18835"
                     /old_locus_tag="SAMN05661093_03838"
     CDS             19729..20124
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787751.1"
                     /locus_tag="B9C43_RS18835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03838"
                     /product="ectoine synthase"
                     /protein_id="WP_084427901.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.6e-53, bitscore:
                     176.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRTTHEVTDTERDVQTPNWRSKRLVLAGEQVGFSVHETTLYPN
                     TVNDFWYANHVEAVFVVEGEGELEDKETGVVYQLAPGSMYLLDGHERHQLRPRTLMRTV
                     CVFNPPVTGREVHDENGVYPLIAEGAT"
     gene            20121..21032
                     /gene="thpD"
                     /locus_tag="B9C43_RS18840"
                     /old_locus_tag="SAMN05661093_03839"
     CDS             20121..21032
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230318.1"
                     /locus_tag="B9C43_RS18840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03839"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_033391015.1"
                     /sec_met_domain="PhyH (E-value: 1.4e-31, bitscore: 107.3,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTSTRAADRYPTRVIGEPGLIERTDPTVWANAPGPVDAATLAS
                     HDAKGYSVDEGVLSKQEVRTYWQELVRLTGDTRLRADERVVIEKESQEIRSIFEVHKIS
                     QLIAELIRDPRILDRARQLLGSEVYVHQSRVNFMPGFKGKGFYWHSDFETWHAEDGMPA
                     PRAVSMSLALTDNYPFNGGLMVMPGSHRTFVPCIGQTPANHYKESLKEQEIGVPSRENI
                     TALAAKHGIDQFTGEAGSALWFDANIMHGSGNNITPFPRSNIFVVFNSVENTLQEPFAA
                     PAPRPTFIASREFTPLARGPRV"
     misc_feature    complement(21232..21243)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.27"
                     /tool="antismash"
     gene            21303..23906
                     /locus_tag="B9C43_RS18845"
                     /old_locus_tag="SAMN05661093_03840"
     CDS             21303..23906
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="B9C43_RS18845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03840"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_084427903.1"
                     /transl_table=11
                     /translation="MRTGETGEDDHAVIRFGVLGPVQAVVNGEPVALGGPGVRGLLAML
                     LLRPNEVVPVEDILDGLWGDDPPLTARTIVQNYVSRLRRQLRLVDPTGSVWIDTQLPGY
                     QLIVDEDLIDVSQATWLLNRARHEHPVRRAEMLREALSLWRGPVLADVSPRISAPELED
                     LRFAVLEARIEADLELGRHAELIGELATFAEAYPFREQMIAHLMLALYRTGRRADALEA
                     YQRFARRAAEDLGIDPGPALRELHERVLNDDSTLLLPAPAPLVPPKVGVVVPAQLPPAP
                     VGFQGRDEELVWLDQLLAEDHGEATPIGVISGPAGIGKTALAALWGRMVDHEFPDGQLF
                     AGLRGFHPEHPPLDPGEVLGQFLLTLGVPANEVPTDTDDRAALYRSLLAHRRVLVMLDD
                     ARDSAQVRLLLPGGSRALVLITSRVRLEGMVARSGAWLLDLGPLPVADSVRVIDSIVGA
                     GRIEQARLDQLVELCGGWPQALRIVGARLAARQEWIADELIAELGDERTRLAALAAEHS
                     DTSVRAGFELTYRRLAEPDAFRLLGMFPGPSIGPGAMAALQSLDVAAARRNLRALADAF
                     LVTETSQDVFVMHDLIRLHAKELAPVGDERAAALDRLVSYYLGAADAARRFFGPMAYPA
                     GKTDNHDFGDVGQALAWFEREWPTLLALLDLAAPGDAWRLARMAHDFWTARPTRPSLVH
                     KGLSIAVSAGDLEGEAWLRHARCALGYSAETVSDAMRVIEIAGRLGDSRLAAVGHEALA
                     TVHSGEEALAELAKALEHYREVGEPELSVPTHARLALLHVEMGDDAAAERHARTAVEHS
                     DAVFTEAFSREVLGRVLSAQGAVSAAQQQWRRSLELYAQVNEHRAEQMRDLIDGV"
     misc_feature    21441..21443
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21558..21560
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    22275..22277
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23436..23438
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(24005..24790)
                     /locus_tag="B9C43_RS18850"
                     /old_locus_tag="SAMN05661093_03841"
     CDS             complement(24005..24790)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017985327.1"
                     /locus_tag="B9C43_RS18850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03841"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_084427905.1"
                     /transl_table=11
                     /translation="MGVGWGSWVAIGDSFTEGLSDVDESGGFRGWADRLAELLAERDPN
                     FRYANLAIRGKMMTEIIDEQVPLAIAAKPELVTICAGGNDLIVPGSDVDELAGQLEQAI
                     VDVQAAGTEVLIFAGPDPKAMPMVRRVRAKVAIYNEHLHAIADRHGVRIVDLWAMHVLS
                     DARAWSDDRLHFSSEGHRRIALRTAEVLGVPTDEDWREPWPPQERITSWFKLRKADLDW
                     TRVHLMPWVKRHIKGESMGDGVTPKRPELRPLGDIPVND"
     misc_feature    24885..24898
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.49"
                     /tool="antismash"
     misc_feature    complement(24886..24899)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
ORIGIN
        1 ccgacatcag cgcggccgat gtcacgtgca gtcgcccgta acccccgaac ttcgctacgg
       61 gcgtgccgac gtaacaggtt cgtggctatg ccgtagagcc atgcacggac tgttgcccgt
      121 tcaggctcgt agcggtcgcg ttgttcccac gcgagcagga acgtgtcgcc cacgagatcg
      181 tccgcagtcg ccgggtcgag ccgccgcgcc agatatcggt gcagaccacg cgcgtgctcg
      241 tcgtagagcc gcgcgagcac cctgtccgcg tcggagcccg tgagatccgg ccgttccacg
      301 ctcgccatcg tcacaacggg tattgcccgc agcctgcccg atcgttccga gaaaaaggcc
      361 gggaatcgaa actcgactcc cggcctctgt gctcagttgg tcagactggc ttctcgccgc
      421 tcaacagctg cgcgcagcgg atcaggccga ggtggctgta cgcctgcggg tggttgccca
      481 gtgagcgctc ggcgatcggg tcgtactcct ccggaagcag accggtcggg cccgcgcagt
      541 cgaccatctg cgcgaacagg tcctcggcct cggtccggcg gccgcacatc aggtacgcct
      601 cgatcatcca ggcggcgcac aggtggaagc cgccctcgtt gcccggcagg ccgtcgtccc
      661 ggtggtagcg gtacacagtg gacccactgc gcagctccgc ctcgatcgcg gtgacggtcg
      721 aggcgaaccg ctcgtccgac gggtcgagca ggccggacag gccgacgaac aacgacgccg
      781 cgtccaggtc cgtgccgtcg taggccgtgg tgaacgactt gacctcgtcg ttccagccct
      841 tggtcaggat gtccgtggcg atcttgtcgc gcagcgcgtg ccattccggg ttcggctggc
      901 ggccataggt ttccgccaac gtgatggccc ggtcgatggt cagccagcac atcaccttgg
      961 agtacacgtg gtggcgcggg cggtgccgct cttcccagat gccgtggtcc ggctcttccc
     1021 accggcgcgc gacggcctcg gccatcgcgt tggtcatctt ccagtcgtcg tcggtgagtt
     1081 tcccgcgtgc cagggaaagc gccgcgacca ggtcgacgac cgggccgaac acgtcgagct
     1141 gaacctgctg gttggcaagg tttccgacgc gcacgggccg cgaacccgcg tagccgggca
     1201 gcgtgtcgat cacggcctca gggccaagac cggtgccggc caacgtgtac agcgggtgca
     1261 gccgctccgg gccgggaacc gtggccagaa ccccgtgcac ccagttgagg aacgcctcgg
     1321 cctcggcggt ggaacccagc gacaccaacg ctttcgcggt cagtgcgccg tcacgcagcc
     1381 agcagtaccg gtagtcccag ttgcggatgc cgccgatctc ctcgggcagc gaagtggtgg
     1441 cggcggccat gatcccgccg gtctcgctgt ggcacaggcc gcgcagcgtc agcgccgagc
     1501 ggatcaccag ttcccgctcg acctccggga accgcaagga gccgagccat tccgtccagt
     1561 accggttggc gcggttcttg cgctccggct ccgggatcgg gtccggtgcc agatcgtctg
     1621 tgccgcaacg cagttccagc agcaccggct cgccgttcgg gctgacgatc gcccgggcgg
     1681 tgtcgtgcat gccgtccgag gtgatctccc agtccacgcc gggggagtgc agcgccatcg
     1741 ggtcggacgt gccgaccacg cgcaggccgt tctcgttgcg caccagcttg accggcacct
     1801 ggccgaactc cgggcgcggc gcgaactcga cgatcgcccg gctgctgccg gtgatcgtgc
     1861 ggatcaggtc cgtgcggtgc ggctgggcgt agtgctccag gtagtccgtg accagcaggc
     1921 ccgaccagcg ggtctccacg gtcatcgtgc ccggcaggta acgctgcccc agcggaagac
     1981 cgccgcgttc cggcgtgatc gacaggtgcc cggcgctcgg gccgccgagc aggtcggcga
     2041 acaccgcggc cgagtcgggc tccgggtggc acaaccaggt gacgcgagct tcgggtgtca
     2101 gcaacgcgac cgaacgctcg ttcgccagca tggtcagccg ctcgatcggg gtggcctgct
     2161 cgccgtacag ccagttcctg cgctcctcca acaggaacgc gagcatcgcg gccaccgcgg
     2221 gggtgtcgtc gatgcggaac tgcgcgagcg tctcgccgcc gccgaccttg acgccgaggt
     2281 ccggcccgga cagccgggcg aaggccttct catcggtcac gtcgtcaccg acgaagatcg
     2341 ccgccgtcgc acccatctgg tgccgcagca cgtccagggc gtggcccttg tcggtctgca
     2401 ccacggcgag ctcgatgacc gctttgcctt cggtcacctg cacaccttcc caggtgcacg
     2461 gaccggtgcg gacggcctcg gcgatccggt cggcgatcga ctgctcggcc cgccggtagt
     2521 gcaccgcgat gctggccggc ttgacctcga ggtggacgcc ttcggccccg tcgaccagcc
     2581 gctcgagctc ggcctcgatc ttggtgtgca gttcccgcgc gggtccgttg agcgagtgca
     2641 cgaagccgat gtcgaactcg gatccgtggc tgccgaccaa gtgcacctcg gcgggcagcc
     2701 gcgacatcgt cgcgaggtcg cgcagcgccc ggccggagat caccgcggtg gtggtctcgt
     2761 gcagaccggc aagcgaacgc agcgcgtgca cggattccgg ttggggccgt gctttctccg
     2821 ggtcttcgac gatcggcgca agcgtcccgt cgtagtcgca cgcgaccaac agtcgggggg
     2881 tgcgtgcgag ctgaacgatc gcccgcctca gttcggcggg gagagcctcg gcagtcacgc
     2941 cttctcctcg tgctccagcg tggcagccat tgccactatc gggtgaagtt acgatctgaa
     3001 ctgattcagt tcaacccctg tgaccccaga gcctccagga acgaccgtgc ccaacggtcg
     3061 acgtcgtggg tgagcacctg gcgtcgcaga gcgcgcatcc tacggcggcc ctccgcaggg
     3121 tcgatcgtaa gggccgcatg cagcgcgttc ttcaccccat caagatcatg tgggttgacc
     3181 aggaacgcgc tggtgagctc ggcggccgcg ccggcgaact cactgagcac aagggtgccg
     3241 cccaggtcat gccggcacgc cacgtactcc ttgcacacga ggttcatccc gtcgcgcacc
     3301 ggtgtgacca ccatgacgtc cgcggcggag aagaacgcga ccagctcgcg ccggtccacc
     3361 gactggtgca ggtagtgcac gaccgggtga cccactttgc cgaactcgcc gttgatccgg
     3421 ctgaccacct gctcgatgcc ctggcgcatc cgctggtagt gctcgacccg ttcgcggctg
     3481 ggggtggcca gctggaccat ggtcacctca tcggggtcca cccggccctc gatgagcagc
     3541 tcctgcaacg cgtgcagccg cacgtcgatg cccttggtgt agtcgaggcg atcgaccccg
     3601 agcaagatct tcttcgggtt gcccaggtcg gtcctgatct gctgggcacg ctggatggtg
     3661 tcccgtttgc gggccatccc gtccagtccg gccgagtcga tggagatcgg gaacgcgccg
     3721 acccggaccg gccggtcgcc gacgtggatc aggccgggcc tggtccgcac gccgaccgcg
     3781 gcacggctcg gctcaaggcc gaccaaccgc cgtgccagcc acagaaagtt ctgtgcgcca
     3841 cccggtcggt ggaacccgac caggtcagcg ccgagcagtc cgcgcacgat ctcggtccgc
     3901 cacggcagct gcatgaacag ctcgaccggc gggaacggga tgtgcaggaa gaaaccgatc
     3961 cgcaggtccg gccgctgctc gcggagcaac tgcgggacca gttggagctg gtagtcctgg
     4021 acccacacgg tcgcgcccgg cgaggcgacg gccgcggtgg cctcggcgaa ccggtggttg
     4081 accttgacgt agctgtccca ccacgcccgg tcgaacaccg gaggttccac cacatcgtgg
     4141 tacagcggcc acagggtggc gttggagaag ccttcgtagt agtcgcggac gtcggcggcc
     4201 gacagggtga ccgggatcag tcgcaggccg tcgtcctcga actcctccac gtccacgtcc
     4261 ggcacacccg gccagccgac ccacgcgccg ctcttggatc tcaagaacgg ctcgagggca
     4321 ctgaccagtc cgcctgggct gtgcttccaa cgttgcgtgc cgtcttccgc acgctcgagg
     4381 tcaaccggga gccggttggc cacgacgatg aagtccgcac cgctgttcac cgggagagag
     4441 cctccttgtg atgacactga ctaaaagaca gtagccagtt aggccgctga gcgcgtccgg
     4501 caaacggtca ggtggtaagt ctcacttaga cgccgttgtc tccagctcca gccgttgcca
     4561 cgtcggcccg accagtctga tggcaccgag ccgtcgctcc aacctaccga ggctcactcg
     4621 tacaggttgt gccaggtatt cgccgagaac cacgcccgcg cccagcgcca gggcgatgcc
     4681 gagggccgtc atcagcgtca cgacaccggc cgaggtgccg tcgaccgcga gctcgtagag
     4741 cgaccgatat gtcgtaagtc caggaaacag gggtgtcatc ccggagaccg cgacgacaag
     4801 aggagtgacg cccagtcgtc gcgccatcac tccgccgcag aacccgatcc ccgccgcggc
     4861 aaccgccgac gccacgatcg gcccggctcc accgagcacg agtccgccgt agcccaacgc
     4921 gccgagcgca cccgccgcgc tggcgaccat catcgaccgc atcgttgcgt agctcgccag
     4981 ggcgaagcag cccgccgcgg cagcaccggc cactgtctgc aacggcagcc gcagcgcggt
     5041 cggcggcagc gcctccgcca tgggcacccg tggcaagccc aactccgagg ccatgttcag
     5101 tgccagcaca accccgccaa tgaggcccgc ggtcatcaac gcgacctcca tcgcgcgccc
     5161 tgcggccgtc acgttgtagc ccgtgatggc gtcctgcacg gtgccgacga cgctaagtcc
     5221 ggacagcagg accgtgatgg cagcggccac gacgagcgtt ggtgactcac cgagccaccc
     5281 tgtcgacaca accgcgagcg ccccacccgt ggcgagggcg ccgccaagca cctgctggaa
     5341 gaagaacggc agattgtgcc ggttgagaat ccgtccgatg cggtcgatga cagcggtgat
     5401 gacggcggca gccaacgcga caagcggccc gccacccagc aacacggtga cgctcgcggc
     5461 cataccggcc catgcggccg tcgctaccca tcgtgggtag gggtgccgtg cgttgacgat
     5521 ccggtcgagc cgacgcgcag cctcggttgc cgtcgtcctg cgtcgcgtga tgtcccggac
     5581 aagctgctcg acggcggcga ggcgcgtgta gtccaacccc cttgaccgca cgactcgcaa
     5641 cgacgtcaca ggtgcgaact cagcgccccg atggcagcac gcggtgatgg aggtgaacgt
     5701 cacatccacc tggcactgct caaggccgca agcgtttgcg acagcaatga tcgtcgcggt
     5761 cacatcggag gcgcccgcac cggagctcaa ctgcacttct ccgatccgca acgccaggtc
     5821 gagcacctga ttgacaaccg actcggccgg cacgaactgc gccactacca ctcctcccgt
     5881 gcctcgtttc ccgcgtggca tcgcaggagg aagaagaggt gtaacagtgt cgtgcaccac
     5941 aaacaggttt agcgggaaac ggcccaacgc cccgggctgg ttcaagcgca acgtgcccag
     6001 cgctggatcg gaaggagctc gcaccgtggg gtctgggggc tcggccccca gaagacaccg
     6061 cgtcttgggc ggcccacgct gggagccggc cagcggctga cgccgcccga gccggtgacg
     6121 ggactcgaac ccgtaacctt tcgcttacaa ggcgagtgct ctgccaattg agctacaccg
     6181 gcgaactgtc cgacaacatc gtaagcagac agtcgagcgg ttaagtacac cggctcccgt
     6241 ttagcgcaac cagctcagca gggctccgca ggccatcagg gtgggcaggc accagcgcat
     6301 cgtgttgatc tggcgctgtt tcgtgtcgcg gtccagcacg tgatccgggt acaccgacac
     6361 cgcccaggcc gccgacatca agaacaggct cccggtgacc gctggccaca cagggatctc
     6421 gacaaaggtc gtcggccaca ggaagtacgg cacgaccaaa gcgacgatcc cgagcgacag
     6481 ggcacccgcc gagatcacca agtgccgttt cacggccagg aacgcgatga acaccaccag
     6541 ggcggcaccg aaggacacca ccgcaccggt cctgatgacc gccgtcggca gctcgttcat
     6601 cacggccgga accccggacg ccaggatgac cagaccagcg atacccaaag tgccttggat
     6661 cgcggcgggc acgaacttca ccggctgcag gcctggcgcg aacacccgcg cgtacgaggc
     6721 gggatcgccg aacgcctgct gtggtgtctt gccggtgtcg gcgcagtacg cctcgaccga
     6781 gtcgagcagc tgctcgatcc gttcgctgga cagatccctg gtgcgtaact cccgaagcag
     6841 ggcttgctgc cacggatcga gcttgcgggt gatcatcgtt gctccgagca gggcgggaac
     6901 tttccccaca acctagtcag gcagtcaacc tctcgatctt ggcgggaacg tgcttgtgcc
     6961 aaggagttcc ggcgatcgga tcccgccagt tcgagtcggt tagttcattg ggcgcagtgc
     7021 ctgtcagctt gttgtcgtaa ttcaggccaa ggccgttggg cagagagacg tggccgggct
     7081 gcatgcggtc gttgatttcc acggctgctt ccaccgatcc gcgtgtggtg gtgacgatgg
     7141 cggtgccgtc gtcttgcagg ccaagggctt cggcgtcctg cgggctgatg cgcagcgcgc
     7201 cacgcgtgtc cctgcggcgc catgcagggt cgcgcaagat tgtgttggcg gtgaacgacc
     7261 gtcgttcacc ggcggacagt acgaacggga attcgtcgct cgtccaggcc tgcgtggtgt
     7321 ccagcttgcg gatttcgtcc aacagactgg ggatcgcgag gtggatccgg ccgtcgtcgg
     7381 tgcccacgta gcgccaggcg tcggcgtact cgtcgagtgt gagcgtgatg ccggagcgcg
     7441 agttgagaat cgcctcgaac aacgcttcac cgtcggcgtg ccccgctcgt ttgacggcgt
     7501 cggggtacgt catcgcacac ttctgcgctg cgagccagag aaccgcggcg ttacgagcac
     7561 cgttgggcag cttcggaccc agcgtttcgt agagcacgaa gggtgcgagc ggcgcgagtt
     7621 tgccgctcat cgcccgcagc atcgcctggg caaaggcttc gcgggtttcg gcttcgtgca
     7681 gtggcgcgag atcctcggca gtgacgagcc cgagcgcacg gatcagacgg gcgtagatct
     7741 ccgcttcgtt gagtgtgccc ggcaacggat cgagcaccgg ggcccgcaag tggaacgtgt
     7801 tgcgcgggaa ctccaggttg aagaacgtgg cttcccactt ctcgaactgg cttgccgcgg
     7861 gcagcacgta atgtgcgtgc cgggcggttt cggtcatggc cacgtcgatc acgacgacaa
     7921 ggtcgagcgc gtccaacgct tcgcgcatcc gcggcgagtc ggcgagcgag tggacggggt
     7981 tggcggattc cacgatcatc gcccggaacc gcttggggtg atcggtgagg atctcgtccg
     8041 ggatcacgtt gcacggcacc aggttcgcga acatcggcgt gttggtgacc ggcgtacggc
     8101 ggtcgcggcg cgggtcgtgc ttggcgactg ggaccagcca cgagtgcgtg ttcaccgcgc
     8161 cctgcttggc gaagttgccg gtcagcgccc acagcagctt ttccagatag gagctcagcg
     8221 tgctgtgcgg tgcctgctgg acaccgagat cctccaaaat ggacatactg ctcgcggtgg
     8281 cgatctgcct ggcagccttg gtgatcagct actcggaaac accgcagcgc tgcgcgtatt
     8341 cggcgacctt gatgtgggcc atgtgctcga gcacctgggc ggagtcagtg gtgtgctcgg
     8401 cgaggaaagt gtgatcgacc aagtcctcct ggacgacgac cgccaccatg gcggcgagac
     8461 accacgcgtc ggtgcccggc ttgacctgca agtggatgtc cgcgaggtcg gcggtttcgg
     8521 tccggaccgg atcgatgacg atcaacgacc gcgctggatc ccgtgcgatc tccttgagca
     8581 cgacccgtgc gcgcgggaaa ccgtgtgact gccaagggtt cttgccgacg aagacggaga
     8641 cctcggcgtg ttcgaagtcg ggcgcggtat gtcccctgtg gagctgggcg tccacccaga
     8701 actcgccggt tttctcctgc gccaaggcat tcgaccgatg ccacgcgcga agcccacgca
     8761 tcagcgcggc gctgtaggcg ccgccgaggt gattgccttg cccgccaccg ccgtagaaga
     8821 agatcgactc tccgccgtgc gcgtcccgga ccgccttgag ccgctcggcg atctcggcga
     8881 tggcggtgtc ccagctgatc tcctcgaact cgccattgtc cttgcggcgc aacgggcttg
     8941 tcagccgatc ggacgcgttc tgataatggt cgaggcgcag tgccttgttg caggtgtatc
     9001 ccgccgacgc gacatggtcc ttgtcgcccc ggatccgttt gaacagccgg tcctcggtga
     9061 gcacctcgat accgcagttg cacgcgcaga ggatgcacac cgacttgtgc cactggtcca
     9121 tcgcagcgct ccggaagagt cgattatgcc aaccgtcata ctcgaccggt tccgcacggg
     9181 cgtcaagcgg agtcgacgag aagatgccca agcatccgag tcatctcccg ctcaacccgg
     9241 tcaagagccc tggtgtcctg ccgagcacgc gcgaccaccg tcgccccctc gatcgacgtg
     9301 atcagcaagg tcgccgcgga caccgcccgt tcttcggaga caccccgcct gaccagcaaa
     9361 tccgcaatgg tccgttccca cttgccgaag acctcacccg cagcccgata agcatcgacg
     9421 gactcggccg cgccgagagc ggcagcgaca atcgggcagc tggtctgaac gttctcggag
     9481 agctccgccc gccagaactc gaagagcgcc cgcgtcaact cgatgggatc gtcgaacttg
     9541 ccgatcatcc ggttcatcac ctcgccggcc catgcggtgg cctcggcggc aagctggttc
     9601 ttcccaccgg gaaagtggtg atagatcgac cctcgcggcg ccccactgtg ctcgatgacg
     9661 tcagcaaggg aagtacccgc gatcccccgc tcccggaaga gcgtcaccgc actgtgcacc
     9721 atcgccttac ggacatcgcc tgccacggcg accagcgtac tatgacgatc agcatagtga
     9781 aatgctctga cgtttcactg tcatcttttc aagccagctg aagccgaccg tcaattcagc
     9841 caattgcgtc acggagactt gccgcgttgt tctcttggta gccaagagat ttgtcagtag
     9901 aattgccgtg agtcagcgtg gccataccgt gagtcgggtc gcagtcttgg cgcacggtca
     9961 acctccctgc tgtcttcatc ttcgaggtgg ggaggtggag atgaacgacc gtatcccaca
    10021 gggcctggtc ggtaccggcc gagtgccgct ggtcaacctg atcatttcat tcgacaccta
    10081 cgagtgcttt ctcgtgcaac tcggaccggt tgggcccagt tgcccccgtg tcgcgttagc
    10141 cgccgggccc ggcggactgg agcaactggg cccgggcatc gaatccgcga ccaagtccgc
    10201 gctcggcttg gttgtgacct atgtcggggt gatgtccttc gaagtcacct caaccgcgat
    10261 agacatgtac gtcttggtca gcgcccgtga accggccacc tggcccatcg gtacaacgct
    10321 gatgaccctg ccggagctcg ttcgagcagg cgcggacatc tccttgatcg gcctcttcca
    10381 agcagccgcg agccgggccg aggccgaacg attcgctttg aagatcggcg gccctgtgcg
    10441 tcacgccctc gccagaactg tcgagcacct cgaggagcgc ttcacagtgg aggacggtcg
    10501 cgcaggttgg tcgcagtacc tgagcaacga cgccgtcggc gtaatgtcct ccgcgcaagg
    10561 actgctggcc ttggcgcacg cgtctgtcgc aagtcgttac atcgagcctg tcgcccggtg
    10621 cctcgagcaa gcgcagaacc ctgatggcgg ctggcaagtg aaacattcgc tgcacggcga
    10681 gcccactcag atctccatca cggagagcac gtgctactgc ctgtgggcct tggtcgagtc
    10741 gggacgtacc gaggaatgca tcgcggtctc aagcggggcc gcgtggctga tgaacaccca
    10801 acgaccgtca ggcggctggg gtgtctccga acgcagcgcc gaagcgcaag tgatagcaac
    10861 ggcttttgcg gtcagaatgc tggcccgtct cggcaaccgg ggtgcggtag gtcgaggagt
    10921 ccaatggctt cgtgacaacc aacgcgagga cggttcctgg ccactggacc gtgcggtggt
    10981 ctcaccaacg gagccagacc tctcgccacc ggcaccaacc gcccatgccg tcatcgcttt
    11041 gctgtcagca ggcgtgcccg ccaatgacaa cgccatcatc cagggcgtcg cgtacttgcg
    11101 tcgacggttc aacagcgctg gcgtcgaacc gtggcgttcg gcgctgtccg acacgcttgt
    11161 cgatcctcga accgactctc gcttgatctt tcggcactac acgacgccat gggcgctggt
    11221 ggccttgagt caggcaggcg cgagcttgag cgatccgctc gtccagcgcg gcatcttgca
    11281 actactcgcc cagcagatgc ccagcggtgc gtggcgatgc aacgccacag tgcccgcctc
    11341 gccgacaatg tgggccgcgc atgacacggt tttcgcgctg aagaccgtgg tttcaatagg
    11401 cgtacgaatt ctccaatcgg caccggtcct cgggctgacc accgcatcac tcgagtcaat
    11461 gatgatgagt tttctgttga ccaatggatc gccgtggccg ggtgctcaag aagcaatggg
    11521 agcgtgatcg tgcggccagc ccgatgatca ttttttcgtc caaatcggac gcgacgacgc
    11581 ctgaaggcct gcttcgagac ggtggtttta tcggatacga gcagtcgttg ggcgaggtgc
    11641 ctccacatgg gtaactcgca acgccgtggg tcgtagcgcg ttggttccgg cgggcgcccg
    11701 ccgatgtgag tacccgtcgc gctcgtgggc tgacggtgtg gtggaatcgg ccttcgcgaa
    11761 cgaacgtcac ctgctgttca ggggcaagtc gcagttcgac atgctcgcgg gtctctatgt
    11821 atcaaccctc tactttagcc ttgagcggct ggtgcgataa tcccgcgcat ggtctcgtcg
    11881 aggtttcgac ggatggtctc gtcgggaccg cccgagtcgc cacatgtgcc gtcggtcaac
    11941 tatcacgtgt ggcaggcgtg caacatgcgc tgccggttct gtttcgcgac attccaaggt
    12001 gtgcgcaaga atgtcctgcc tgctggacac ctggatcgtc ctgacgccat gcggattgtg
    12061 cgagcgctgg ccagggccgg attcacgaaa atcaatttcg caggcggcga accgttcttg
    12121 tgtccatggc tcgtcgacct ggtcgtctac gccaagaagc tcggcatggt gacctcggtg
    12181 gtcaccaacg gcagctactt cgaccgatct gtagcgtctg acctgctgaa acatctcgac
    12241 tggctggtgc tgagcgtgga cagcctgcat ccggcgacag ccattcggat cggccgggtc
    12301 aaggctcaca agccaatttc caagcggcag tatcttgcca tctgtgagcg agtgcacgcc
    12361 gccggtgtca atttgaagat aaataccgtc gtcacctcgg cgaactacgg tgaggacttc
    12421 agggacttca tcatcagggc ccggcctcgt cggtggaaga tcatgcagat gcttccactt
    12481 caaggtcccg attcgcggtg tgccgaggat ttgatcgtgg atcgcgacgg tttcaaccac
    12541 tttgtcgcga agaatcgccg agtgcgcaag aacggcatcg tcgtggttcc cgagacgagt
    12601 tcggacatgg tcggcagcta cgcgatgatc gacccggctg ggcgctttta cgacaatgtc
    12661 tccgggcagt acaagtacag tcagccgatt ctggacgtgg gagttcgcgc ggccttctcc
    12721 gaagtggacg tttcggccgc ccgatttctc gctcgtgacg gtttgtacga cttctggggc
    12781 gggtggaagt ggcgccgcgt cggcagctgg gcgcagctgc ggggctatct gcgcaacagg
    12841 tggcggccat ccgccgtgtc gagcgcaacg ccgttgacga ccgcggcgac ggccgaaccc
    12901 gtgtggctcc aggcccggat ttcgcggcgg accgatgtac tcgagtctgg tcaggctacg
    12961 gccgtaatat cctcaacctg agggcgctga cctgcgggga cgtgtggtac acctgggacg
    13021 ctgaagggtg ggaggcgtcg tggctgagga gcgggatccg gtcgaccggg tggtggcgca
    13081 ggcgagcagg ctcgcgggct ggctggccaa gacgagctgg caggcggctg gccgtctgcc
    13141 aggtggcgaa gccgcgcaac ggcagttccg gaaagccgag aaggccgttc tcgaccaggt
    13201 acgcaagcgc ctcgacgaag aaggaacctt cacgggcaag ctgatcgaag cccctcccgc
    13261 tgtggtcgat gggcacgttg atccggtgcg gtcggcgatg gccgagttgt tgcggctttc
    13321 caccgagctt gatcgggagc aggggcggca ccacctcttc atgtcgatcg tccgccagct
    13381 cgttcccgat gaggcgcgga tcctcgctgc gttgagcgat ggtgaggtgt atgcccttgt
    13441 gcatgtggct gggcggtcga cgttgggtgg accgcagcgg attgtgctgc ggaacgcttc
    13501 ctcggttggg cgggcggccg gtgtgatgtt gccggatctc gttccggact acgtcacgcg
    13561 gctgctgagt ctcggcgttg tccaaactgg acctgaggac caggctctca gcactcagta
    13621 cgacatcctg ctcaccgagg atcgggttcg taccgccgag accgaggttc gcactgtcca
    13681 caagctcagc ccgcggtacc tgaaacgaac cgtcaaactg tctactttgg gcacgcagtt
    13741 ctgggacgcg gcgcggccgg gatgatcgac gagatcgtcg ccgatttcca gcggaactgg
    13801 catgtttacg cttccatgcc gctcatcgcc gcattgatcg ggtacgtcac caaggtcgtc
    13861 gccatccgga tgatgttccg gcccatcgag ttccggggaa tccggccgtt cttcggttgg
    13921 caaggcatcg ttccgcgcaa ggccgcgcgg atggcggcca tcgcgtgcga caccatgacc
    13981 gatcggctca tctccgccgg tgaggtcgtg cgacgactcg atcccgagcg gggttgccaa
    14041 ggagttggag cagccgctgc tcgaggcggt tgacgagatc acccgcgaga tcgccgagga
    14101 gtaccagccc gcgctttggg agtccttgcc gccgcaggcg caggacctcg tcgtccgccg
    14161 ggtccaggcc gaggcgccca aggtcgtcaa gggcattctg gccactattc agtccgatgt
    14221 ggactctgtg ttcgacctca agggcatggt ggtcgagaac ctcgtcaagg acaaggaact
    14281 gctcaaccgg atctttctcg aggcgggcaa gcgggagttc cagttcatcg cgcggtccgg
    14341 catcgtgttc ggcttcgcca tcggcctcat tcaaatgctt gcttgggcca cgctgaaatc
    14401 gccgtgggtg atgccgatct tcggtggcct caccggttgg ttcaccgact ggctcgcact
    14461 gaaaatgatc ttccatccgc gtgagccgag gcgctacttc gggctgttca cctggcaggg
    14521 gctttttctc aagcgccgca aggaagtcgc ggctgactac ggcgcactga tcgccaagga
    14581 gatcatcaca ccgcacaacg ttctgcacgc tgtcctgcgc ggaccattgg ccgatcggct
    14641 gttcgcagtg gtggaacggc agatcaccaa cgccatggac cggcagacca ggctcgctcg
    14701 cccgcttgtg gcgatcacgg tcggcagccg ccgatatcaa cagctgaagc acagcgtcgc
    14761 cgagaaggtc atgcggcgga tgccggacac gctcgccttc atcgaggatt acgccgaaga
    14821 ggcgatggat atccgcaaca cgctcgtcca gaagatgcaa gagctttcgc ccgaggagtt
    14881 cgaagatctg atcaggccgg ccttccagca ggatgaatgg attttgatca ccgtcggcgc
    14941 cgtactcggc ttcgccgtcg gcgagctgca ggtcctgctc gtcgagaacc tggccaactg
    15001 acccgtgtta tccgtgtgcc actattgtta acagtccgcg gaaacgcgtc gatggtccgg
    15061 tggtcgcatt ctccggcaga ctcgacaatc ggcgaggtgg gaaagatcat tccaagacga
    15121 gtggccggtg ggtcgctggc gtacccacag gccagcctgc tcgggcggct gtcggaacgg
    15181 accagggagg atttcctcgc ggtcggcgtt tcggaaagca ggccggcagg tatgacaatc
    15241 atcagtcagg gggaaacaga ttcctcagca ctgttgttgc tgcacggatc ggtgaaagtg
    15301 caggccacgg acccggccgg ggaacggacc ctgctcgcga tcagggtcgg tggtgatctc
    15361 atcggcgaga tggcggcact cgatgtcggc ccgagatctg cgacagtgat cgcgtgcacc
    15421 gacattttct tcaagcggat gaccaaggct gagctgcgga acttcctggc ccgtcacccg
    15481 gatgcggcca tcgaggtggc gacgatgttg agcgaacgcc ttcgatgggc cgaccgtcga
    15541 agaatcgaac acggtcgtcc ggcgagcgtg cgggtggcaa gggttcttgt cgacctatat
    15601 gaggcgtatg gcacccgttc cggtggtcac tgggatctga gtgtgccgct caccagggaa
    15661 gaactcgcgt cgatcgccgg tatcaaactg tccaccgcgg aaaagatcat tcggactttt
    15721 caacaggaag gcctggtcag cggccgttac cggggcatcg cggttctcga tatgagcagg
    15781 ctgagacagc gcgccgaaat agcgtgactc ttgtactgtt aaaaagttga accaagcggg
    15841 cgagcttgtt gcgttaaatg gacacgaacc cgtaccagtg ccgctttcat acgaacgacc
    15901 tactgcatga ttacgcagag caccagcatc cctcggatcc gtccacgaag ggtctaattg
    15961 tatggcagat acgggcttcc ggcggtcgct ctatgtcgga gttgatattc gcgggtacgg
    16021 cgccgcgccg gagcagcgcc agcagaaatg gcaggagacc ctgctgcgat ctcttgatcg
    16081 cgccgcgtcg tcaatgggat tgaaccggac acgctggtct cgtcagcaac acggcgacgc
    16141 cgaactggcc gttcttcccc acgacgaacc tgagccgctg gtggtcgacg gcttcacccg
    16201 ccgtctggaa gccgaactgc gccagcacaa cgaggacatg ctgccgtggg cccggctgcg
    16261 gatgcggatg gcggtgcacc acggcgtggt tgtcaacggt cccaacggtt atccttgccg
    16321 ggacgcggtg gtggtgagca ggttgctcga ctccaagcca ctgcgcgggg tgctcgaaca
    16381 gtggccggag gccaacctcg cggtgatgct gtccgatttg gtctaccggt cggtcgtcga
    16441 agcggggcac acttcgctgc gtaccgacca gttccgccgg cttgccgtgc gggagaagga
    16501 attcaaggga tacgggtggc tgtggctgcc cggttgctcg gacacgatcg acatgtacgc
    16561 acgtccgatc gtgtcgaggt gggactccgc cggtgtgcaa gcgcggccct atgtggtcag
    16621 tgccgatgag gtgtccgatg tagttgtccg agggcggcac cggaccactg cgcagcgcgg
    16681 gttcatcagc ggatgaggtc ggggtggcct tgcccccaac gccaggccac ctcgcctttc
    16741 gcggcctata ttcagcgctg tggtgtacca agccgatgaa cggcgatacg acaaagcgga
    16801 attccggcgc agtgggcgca gcggactcaa actgccgctg atctcgctgg gcctgtggca
    16861 gaacttcggc ggtgcccggc cgtacgagca cggcaggcag atcgccaggc gcgcgttcga
    16921 cctcggtgtc acgcacttcg acctggccaa caactacggt ccgccatacg ggtccgccga
    16981 ggagaacttc ggccggatcc tgcgcgacga cctgcggccg taccgcgacg agctggtgat
    17041 ctccaccaag gcgggctacg acatgtggcc tggcccgtac ggcgaccacg gttcgcggaa
    17101 gtacctgctg gcctcgctcg accaatcgct tggccggatg ggccttgact acgtcgacat
    17161 cttctactcg caccggttcg acccggaaac accgctggaa gagacgatgg gtgcgctggt
    17221 cagcgccgtg cagcagggca aggcgctgta cgccggcatc tcctcgtact cgcccgccaa
    17281 gaccaaagag gccgctgagc tgctcaaaca ggccggtgtg ccgctgttga tccaccagcc
    17341 gtcgtactcg atgctcaacc gctggatcga gccggagctg ctggacaccc tcgaggacgt
    17401 cggcgctggc tgcatcgcgt tctcgccgct ggcgcagggc ctgctgaccg acaagtacct
    17461 gaccggcgtg cccgaggggt cgcgtgcgtc gcagcacggc tcgttgcagc aagaccacct
    17521 ctccgaggag aatctcaacc gggtgcgtgg cctcaacggg atcgcgcagc agcgtggtca
    17581 gagcctgtcg caactggcgt tgacctgggt tttgcgcgat ccgcgggtca cttccgcgct
    17641 gatcggcgtg agctcggtcg agcagctcga gcagaacctg gccgcgctgg acggcccgcc
    17701 gctgaccgac gcggagctga ccgagatcga caagtacgcc gtggagtccg ggttggacct
    17761 gtggcggccg tcacgtgtag ccggctgacg ttctggcaac gcgcgtgcgc gcgacgctaa
    17821 gcaagcgcgc acgcgccgtt caacagtctg tactgatcaa cacaggccgt ttcgcgttcc
    17881 cccaggtcgg ccgtccgggc gagacccgat gggctgatcg gtggaaacac ctctgttacg
    17941 ttcccttggc atgtccggaa aaaccttcgg ccaggcggta gtggatgtgc cgtccacttc
    18001 ggacggtgcg ggaatgtggc ggctggcgcg cgattcgcgc acgctcgacc tgaactcttc
    18061 gtactcctac ttgctgtggt gcagagattt cgccggtacc tccgcggtcg tgaagatcga
    18121 cggtgaggtg atcggcttcg tcaccggata cctgcgcccg aaccagcccg acacgctggt
    18181 gatctggcag atcaccgtgg cggacgaaca tcgcggcaga ggtttcgcga cggcgctgct
    18241 ggacagcctg gtgcgccgca ccggcgccag acatctcgaa gccactgtca cttcggacaa
    18301 cgactcgtcc atcgcgatgt tccgcgcgct cgccgcccgc tggggtgcgg gcctcaccgg
    18361 caaccagctg ttcagcgccg accagttccc tgacgaccac gcggccgagt tcctgttccg
    18421 aatcggcccg ttcgtgccgg tcaacgcgcc ttcctagctc atctgaatca cacggagaac
    18481 cgtgaacatt ttcgagacgc tcgaatccga ggtacgcagc tactgccgtg gctggccgac
    18541 caccttcgac aaggccaccg gcagcctgct ctacgacgaa accggcaagg agtacctgga
    18601 cttcttcgct ggagcgggat cgctcaacta cggtcacaac aatccgctgc tgaagcgggc
    18661 cgtcatcgac tacatgctcg ccgacgggat cacgcattcg cttgacatgc acaccgcggc
    18721 aaagcgcgac ctgcttgagt ccttcgcgga catcgtgctc aagccgcgga acctcgacta
    18781 caaggtgatg ttccccggcc cggccggtgc gaacgcggtc gaagcggcgc tcaagctggc
    18841 ccgcaaggtg accggccgtg aggcgatcat caacttcacc aacgccttcc acggcatgac
    18901 tctcggcgcc ctgtccgtga ccgggaactc gatgaagcgc agcggcgcag gcattccgct
    18961 cgtgcacgcg acgcctatgc cgtacgacaa ctacttcgac ggccagactc cggacttcct
    19021 gttcttcgaa cgccttcttg ccgacagcgg cagcgggctg aacgagcctg cagcggtcat
    19081 cgtcgagacc gtgcagggtg aaggcgggat caacgccgca cgagccgaat ggctacgcgg
    19141 actggccgat ctctgccagc gcaacggaat tctgctgatc gtcgacgacg tccagatggg
    19201 ctgtggccgg accgggccgt tcttcagctt cgagatcgcc ggcatccagc cggacatcgt
    19261 gtgcctctcc aaatccattg gcggatatgg gcttccgctc gcgctgactc tgctcaagcc
    19321 cgagctggac gtctgggaac cgggcgagca caacggaact ttccgcggca tcaaccctgc
    19381 cttcgtcgcg gcaaccgaag cgctgaaggt ctactggcag gacgacaagc tcgagaagag
    19441 cacgctggcc aagggcgagc aggtcggccg ggcgctgacc gggctcgtcg agtcctaccc
    19501 ggacgttcag atgcgtgcca aaggccgagg actggcaagg ggtttgcagt tcgcggacgc
    19561 cgaactcgcc gaccaggtgt gcaagaacgc cttcgaagca ggcctgctga tggagacgtc
    19621 cggaccggac ggtgaggtcg tgaagctgat gccaccgctc accatcagtg atgacgagct
    19681 ggaggccgga ctgtccattc tggcggcttc ggtgaaggga gtcctggctt gatcgtccgt
    19741 accacgcacg aggtcaccga caccgaacgg gacgtgcaga caccgaactg gcgcagcaaa
    19801 aggctggtcc tcgccggtga gcaggtcggg ttctcggtgc acgagaccac gctgtacccg
    19861 aacacagtca acgacttctg gtacgccaac catgtcgagg ccgtcttcgt cgtcgaaggc
    19921 gaaggtgagt tggaggacaa ggaaaccggc gtggtctacc agctcgcgcc tggctcgatg
    19981 tacctgctcg acgggcacga acggcaccag ctacggccga gaacgctgat gcgcacggta
    20041 tgcgtcttca acccacccgt caccggccgt gaagtccatg acgagaacgg tgtctacccc
    20101 ctgatcgcgg aaggagcgac atgacagtca ccagcacccg agctgcggac cgctacccga
    20161 cccgagtgat cggtgagccc ggcctgatcg agcggaccga tccgacggtc tgggcgaacg
    20221 cgccggggcc ggtcgacgcc gcgacgctgg cttcgcacga cgccaagggg tactcggtcg
    20281 acgagggcgt gctcagcaag caggaagtcc ggacgtactg gcaggaactc gtccggctga
    20341 ccggcgacac gcggctgcgc gcggacgagc gcgtggtcat cgagaaggag tcccaggaga
    20401 tcaggtcgat cttcgaggtg cacaagatca gccagctgat cgccgagctg atccgggatc
    20461 cgcggatcct cgaccgggcc cgtcagctgc tcggctcgga ggtctacgtg caccagagcc
    20521 gggtgaactt catgcccggc ttcaagggca aagggttcta ctggcactcg gacttcgaga
    20581 cgtggcacgc ggaggacggc atgccggcac cgcgtgcggt gagcatgtcg ctcgcgctga
    20641 ccgacaacta cccgttcaac ggcggcctga tggtgatgcc cggatcgcac cggacattcg
    20701 tgccctgcat tggccagaca ccggccaacc actacaagga gtcgttgaag gaacaggaga
    20761 tcggcgtccc cagcagggag aacatcaccg cgctcgccgc caagcacggc atcgaccagt
    20821 tcaccggcga ggcgggctcg gcgctgtggt tcgacgcgaa catcatgcac ggctccggca
    20881 acaacatcac gccgttcccg cggtcgaaca tcttcgtggt gttcaacagt gtggagaaca
    20941 ctttgcagga gccgttcgcg gcgcccgcgc cgcggccgac cttcatcgcc agccgcgaat
    21001 tcaccccatt ggcccgtggg ccccgggtgt gatggatcac atgcgctctg ttacggttag
    21061 tgcgtactga tctcgctcag ccggatgcgg tcacgagcca gtcggtcttc cactcggggt
    21121 ggggtcggcg aaacacgtga ccaggccgtg tgagtgtgac cccttgccaa ccggatcggg
    21181 accgggcggc aaggggtcga cttctgcctg gtgctttccg ccgattgcgc ggtaaacctt
    21241 tacttatccc cccttcttcg acgtaccttg gtcaccggca gtaagggacg ggggaggacg
    21301 aagtgcgtac gggggagact ggtgaagacg accatgccgt catccggttc ggtgtgctcg
    21361 gaccggtgca ggcagtggtc aacggggaac cggtggcgct gggcgggccg ggcgtgcgcg
    21421 gtctgcttgc catgcttttg ttacgcccca acgaggttgt cccggtagag gacatcctcg
    21481 acgggttgtg gggcgatgat ccgccactga ccgcgcggac catcgtgcag aactacgtat
    21541 cgcggttgcg cagacagtta cggctggtcg atcccactgg atcggtctgg atcgacacgc
    21601 agttgcccgg ctaccaactg attgtcgacg aggacctgat cgacgtcagc caggcgacgt
    21661 ggctgctgaa cagggcgcgg cacgaacatc cggtgcggcg tgcggagatg ctgcgggaag
    21721 cgctgagcct gtggcgtgga ccggttctcg ccgacgtgtc gccgcggatc agcgcgccgg
    21781 agctggaaga tctgcggttc gccgtgctgg aggcgcgaat cgaagccgat ctcgaactgg
    21841 gcaggcacgc cgagctgatc ggcgagctgg ccaccttcgc cgaggcgtat ccgttccggg
    21901 agcagatgat cgcgcacctg atgctggcgc tgtaccggac cggccgtcgg gcggacgctc
    21961 ttgaggcgta ccaacggttc gcgcgccggg cagccgagga cctcggtatc gatccaggcc
    22021 cggcactgcg ggaactgcac gagcgcgtgc tcaacgacga ctcgactttg ctgctgcccg
    22081 cgcccgctcc gctcgtgccg ccgaaggtcg gtgtggtcgt gcccgcgcag ttgccgcccg
    22141 cgccagtcgg attccagggg cgcgacgagg aactggtgtg gctcgaccaa ctgctcgccg
    22201 aggaccacgg cgaggcgaca ccgatcggtg tgatctccgg gcccgccggg attgggaaga
    22261 ccgcactggc ggcgttatgg ggccggatgg tcgaccacga gttccccgac ggccagcttt
    22321 tcgctgggct gcgcggtttt caccctgagc acccgccgct cgaccctggc gaggtgctcg
    22381 gccagttcct gctgaccctt ggcgtaccgg cgaacgaggt gcccacggac accgatgacc
    22441 gcgcggcgct ttaccgttcg ctgctcgcac accggcgcgt gctcgtaatg cttgatgacg
    22501 cacgggattc cgcgcaggtc aggcttctgc tgccgggcgg atcgcgggcg cttgtgttga
    22561 tcaccagccg cgttcgtctt gaagggatgg tggcccgcag cggtgcctgg ctgctcgatc
    22621 taggaccgct tccggtggcc gactcggtgc gggtgatcga ctcgatcgtc ggtgccgggc
    22681 ggatcgagca ggcccggctt gaccagctcg tcgagttgtg cggcggctgg ccgcaggcgt
    22741 tgcgcatcgt cggcgcacgg cttgccgcgc gccaggaatg gatcgccgac gagctgatcg
    22801 ccgaactcgg tgacgaacgc accaggttgg ccgcgttggc cgcggaacac tccgatacca
    22861 gtgtgcgggc cggtttcgag ctgacgtacc ggcggctggc cgagccggac gcgttccggt
    22921 tgctcggcat gttccccggg ccgtcgatcg gtcccggcgc gatggccgcg ctgcagtcgc
    22981 tcgacgtcgc cgcggcccgg cgaaacctgc gggcgctcgc cgacgcgttc ctggtgaccg
    23041 agaccagtca ggacgtgttc gtcatgcacg acctcattcg cttgcacgcc aaggagctcg
    23101 ctccggtcgg cgacgagcgt gcggccgcgc tcgaccggct cgtgtcttac tacctcggtg
    23161 ccgctgacgc cgctcggcgg ttcttcgggc cgatggcgta tcccgccggg aaaacggaca
    23221 atcacgactt cggcgatgtc ggccaggcgc tggcgtggtt cgagcgggag tggccgaccc
    23281 tgttggccct gttggacctt gctgcccctg gcgacgcatg gcgactcgcc cggatggcgc
    23341 acgacttctg gacggcccgg ccgacgcggc cgtccctggt ccataaggga ctgtcgatcg
    23401 cggtttccgc tggtgatctt gagggtgagg cgtggttacg gcatgcccgg tgcgctttgg
    23461 gttattcggc ggaaacagtt tcggacgcca tgcgggtcat cgagatcgcc ggtcggctcg
    23521 gcgactcccg ccttgccgca gtgggacacg aagcactcgc aactgtccac agtggagaag
    23581 aagcgctggc ggagttggcc aaggcccttg agcactaccg ggaagtagga gaacccgagc
    23641 tttccgtgcc cacgcacgct cgactcgcct tgctgcacgt ggaaatgggc gacgacgcgg
    23701 cagcggagcg gcacgcccgc accgcggtcg agcactcgga cgcggtcttc accgaggcgt
    23761 tcagccggga agtgctcggc cgcgtgctgt ccgcgcaagg cgcagtttcc gccgcacagc
    23821 aacaatggcg gcgatccttg gaactgtacg cgcaggtcaa cgagcaccgg gcggaacaaa
    23881 tgcgggattt gatcgacggc gtttagcgca cagttagtga tgttgattgc cgagctggca
    23941 ggctacccgc ggcgccacac cgggggcggc cggcacgccg agggggagtg ccggccgggc
    24001 accgtcaatc gttgacggga atgtcgccaa gtgggcgcag ttccgggcgc ttcggcgtca
    24061 caccgtcccc catggactcg cccttgatgt gccgtttgac ccacggcatc aggtgtaccc
    24121 gtgtccagtc cagatcggcc ttgcgcagct tgaaccatga cgtgatccgc tcctgcggtg
    24181 gccacggctc acgccagtcc tcgtcggtcg gcacaccgag cacctcggcc gtgcgcaacg
    24241 cgatccgccg atgcccctcg gaggagaagt gcagccggtc gtcgctccac gcccgcgcgt
    24301 cactgagcac gtgcatcgcc cacagatcca cgatccgcac accatgccgg tcggcgatgg
    24361 cgtgcaggtg ctcgttgtag atggcgacct tcgcgcgaac ccggcgcacc atcggcatcg
    24421 ccttggggtc cggaccagcg aagatcagca cctcagtgcc ggcagcctga acgtccacaa
    24481 tggcttgctc aagctggccc gccagctcgt ccacatcgct gcccggcacg atcaggtcat
    24541 tgccgcccgc gcagatggtg acgagctcag gcttggccgc gatggccaac ggcacctgct
    24601 cgtcgatgat ctcggtcatc atcttgccgc gaatggcgag gttggcgtac cggaagttcg
    24661 ggtcccgctc cgccaacaac tcggcaaggc ggtccgccca cccccgaaac ccgccagact
    24721 cgtcgacgtc gctcaacccc tcagtgaagc tgtccccgat cgcgacccag ctaccccagc
    24781 ccacgcccat ccctcccgaa ggtcgttgcc gcccccaacc aaaggccagg atgcctaatg
    24841 gacggctacc tacgccaccg tcggttgcga ctggcaacat cggagtcacg gtgagtgatt
    24901 tcccgtacat cgcgggaggc cggtttgtcc aggtgtcgac ggctttgacc agcgaagtcc
    24961 gtggcgaaca ccactcgctg cagccagctc gcccacagtg agagtcactg tcccattacg
    25021 actgcaggtg tatgccggaa ccgatcacgt cgtcccgaca tcacagttac gatgcggagt
    25081 tggagaggaa tcgcctaacc gggggacacg atgccagacg ggac
//
