LOCUS       NZ_FWXV01000002        10300 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Kibdelosporangium aridum strain DSM 43828, whole genome shotgun
            sequence.
ACCESSION   NZ_FWXV01000002
VERSION     NZ_FWXV01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Kibdelosporangium aridum
  ORGANISM  Kibdelosporangium aridum
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Kibdelosporangium.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900176515.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:02:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,283
            CDSs (total)                      :: 11,193
            Genes (coding)                    :: 11,032
            CDSs (with protein)               :: 11,032
            Genes (RNA)                       :: 90
            rRNAs                             :: 3, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 3, 5 (16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 161
            CDSs (without protein)            :: 161
            Pseudo Genes (ambiguous residues) :: 0 of 161
            Pseudo Genes (frameshifted)       :: 38 of 161
            Pseudo Genes (incomplete)         :: 135 of 161
            Pseudo Genes (internal stop)      :: 6 of 161
            Pseudo Genes (multiple problems)  :: 17 of 161
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:58:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1673447
            Orig. end                         :: 1683747
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FWXV01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10300
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="4"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10300
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10300
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5300](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5300)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(368..384)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 20.44"
                     /tool="antismash"
     gene            433..1005
                     /locus_tag="B9C43_RS17525"
                     /old_locus_tag="SAMN05661093_03567"
     CDS             433..1005
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF025605.5"
                     /locus_tag="B9C43_RS17525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03567"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_084427573.1"
                     /transl_table=11
                     /translation="MVRADKREAVMQAAMKVFGQVGYLLASIDVIAAEANVSTRTIYNH
                     FDNKEKLFAEVLLTSSRQVAEAHEALIDRNLNDATDLETALVNLAEDWNRPTPQLADHF
                     ALSSRMAAEREHFPKEIYEAWRETGPWRVQRALASKFDELRDQGKLDMPDTRFAAHLLS
                     VMLTEGRDYKQVVHAFLYGYVPRRSAG"
     gene            complement(986..1321)
                     /locus_tag="B9C43_RS17530"
                     /old_locus_tag="SAMN05661093_03568"
     CDS             complement(986..1321)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230600.1"
                     /locus_tag="B9C43_RS17530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03568"
                     /product="hypothetical protein"
                     /protein_id="WP_084427575.1"
                     /transl_table=11
                     /translation="MAQHAESGRSSESAGVTRAQVVGIVASVVRWVGLLCTLILVIHIL
                     LTVGNANPNNGITSFFASWADPLALGFRDLFTPSDPKAFVLVNYGIAALFWLIAASVLA
                     KIIRRFA"
     gene            complement(1375..1674)
                     /locus_tag="B9C43_RS17535"
                     /old_locus_tag="SAMN05661093_03569"
     CDS             complement(1375..1674)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683932.1"
                     /locus_tag="B9C43_RS17535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03569"
                     /product="hypothetical protein"
                     /protein_id="WP_051897710.1"
                     /transl_table=11
                     /translation="MTTRRWHVTSGRGTAARVVFGVTAIFALIEAVYILLIVLDANTTN
                     GFFTFIQSLAEPLALFFPGLFATGNYNLDVILNYGLAGVFWLVIGSILARIIGR"
     gene            1910..3697
                     /gene="leuA"
                     /locus_tag="B9C43_RS17540"
                     /old_locus_tag="SAMN05661093_03570"
     CDS             1910..3697
                     /EC_number="2.3.3.13"
                     /GO_function="GO:0003852 - 2-isopropylmalate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="leuA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669638.1"
                     /locus_tag="B9C43_RS17540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03570"
                     /product="2-isopropylmalate synthase"
                     /protein_id="WP_033392912.1"
                     /sec_met_domain="HMGL-like (E-value: 9.3e-80, bitscore:
                     264.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTNPDSFRSSRIRKPARPAPADQPVWNAQLGSSMPVHRYRPFAE
                     VVEDVTLADRTWPDNKITTAPLWCAVDLRDGNQALIDPMSPARKRRMFELLVKMGYKEI
                     EVGFPAASQTDFDFVREIITEDAVPEDVRIQVLTQCRPELIERTFEALQGANKAIVHIY
                     NSTSILQRRVVFREEREGIKKIATSAAEMVAELADKYTDTDFRFEYSPESYTGTELSYA
                     AEVCNAITEIWQPTPQRPVILNLPATVEMATPNVYADSIEWMHRNLERRDSVILSLHPH
                     NDRGTGVAAAELGYQAGADRIEGCLFGNGERTGNVCLVTLGMNMFSQGIDPQIDFSDID
                     EIRRTVEYCNQLPVPERHPYGGDLVFTAFSGSHQDAINKGFDALRDAADKAGTPVDQFE
                     WEVPYLPIDPKDVGRTYEAVIRVNSQSGKGGVAYVMKTEHQLELPRRLQIEFSGVVQKM
                     TDSEGGEVSPAQMWDMFSAEYLSATSPLTLQRHRLSDDGHGHDEIAAVVHVEGDEHEVR
                     GNGNGPIAAFVDALASVGFDVRVLDYTEHALTAGDDARAAAYVECAVGDRVLWGVGVDS
                     SIVTASLRAVVSAVNRANR"
     gene            complement(3678..4001)
                     /locus_tag="B9C43_RS17545"
                     /old_locus_tag="SAMN05661093_03571"
     CDS             complement(3678..4001)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B9C43_RS17545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05661093_03571"
                     /product="hypothetical protein"
                     /protein_id="WP_143446375.1"
                     /transl_table=11
                     /translation="MSAAIRPPEAATPIFRNGFATTALALGIVGIGFGLSVLFGLLATV
                     FGALAVLFGVIGVIRARKGRATDGGMAAIGVIAGLIAVAIGIGIMVSMPDQPDSLSSID
                     LLG"
     gene            complement(4169..4984)
                     /locus_tag="B9C43_RS17550"
                     /old_locus_tag="SAMN05661093_03572"
     CDS             complement(4169..4984)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101895.1"
                     /locus_tag="B9C43_RS17550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03572"
                     /product="tyrosinase family protein"
                     /protein_id="WP_084427579.1"
                     /transl_table=11
                     /translation="MGVRKNQQNLTATEKTNLVNALLAIKQSGVYDTFVRQHIDRLNGD
                     SDNGTRIGHRSPSFLPWHRKFLLDFERALQAVDPTVSLPYWDWTTAGAGSSLWATDFMG
                     PNGSPSQNGRVTSGPFAGSSWPLSVRSDSAGFLRRSFGSGGVSLPTARDVRTVLDIRTY
                     DTAPWNSTSAGSFRNGLEGFRGPNLHNRVHVWVNGTMAGAGSPNDPVFWLHHCHVDKLW
                     SDWQIRNGRNTYIPVAGTANVVDIDEVMQPWGDVTPRDMLDHSSHYTYE"
     gene            complement(5001..5300)
                     /locus_tag="B9C43_RS17555"
                     /old_locus_tag="SAMN05661093_03573"
     CDS             complement(5001..5300)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017995.5"
                     /locus_tag="B9C43_RS17555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03573"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_084427580.1"
                     /sec_met_domain="melC (E-value: 3e-20, bitscore: 69.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSRRKLLMTGAAAVAGGAVVGWNALAAQTDFDEIYAGRRIHGKG
                     ELIFVDGDVVHVMRNGDGSYSTSINHYESFTSLRDAARRAVDTLGDLRPVTHVH"
     misc_feature    complement(5265..5281)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.82"
                     /tool="antismash"
     misc_feature    complement(5378..5393)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.88"
                     /tool="antismash"
     gene            complement(5402..6256)
                     /locus_tag="B9C43_RS17560"
                     /old_locus_tag="SAMN05661093_03574"
     CDS             complement(5402..6256)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.5"
                     /locus_tag="B9C43_RS17560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03574"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_084427582.1"
                     /transl_table=11
                     /translation="MELGQGHLKTIIAVAECGSIGRAAIRLGQSQAGVSGNVRRIEKYF
                     GGELFHRSAEGVRTTPLGDWVLVKARTLAADMDQLVSSARSVAGGADRLRIAGQPCPTM
                     LALIPLLPRDVEVRVDHSADWLLQQLSAGSLDVCVSVEPAGFSVPDGVHRKVVADEPYA
                     IGLSRVHPLADRPHIGLSELSDNDWVDTPFGDSGLRLACQQAGFEPRIRYWVADPSAAR
                     LVVRSGRAVGLFTRSAPDGLVLRPLQCNPVRRRTVLYWREPASALIRRLTNVTVNNRTE
                     SPF"
     misc_feature    complement(5444..5446)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6331..7359
                     /locus_tag="B9C43_RS17565"
                     /old_locus_tag="SAMN05661093_03575"
     CDS             6331..7359
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009083238.1"
                     /locus_tag="B9C43_RS17565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03575"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_235038661.1"
                     /transl_table=11
                     /translation="MGSTQDRPTLEDVAAYAGVSRSTASRALNEEMYVSPRAREAVLAA
                     ARDLGYSPNQAARSLVTKRTGAVALVLSEPESKVLDDPYFLIVMRAAFRELANRGSQML
                     VMFVDAPDDIPRTMKFLDGGHVDGALVFAPHSGDPLPVALKLLRVPVVFGGRPGRSSSD
                     LYTVDYDNTAGAQLAVEHLLSVGKRNIVTVCGPQDHPAAMDRLTGWRETLAEKGMPTNG
                     RAENGDFTQTGGEAAMVKLLEREPDLDAVFAASDPMAIGALRALKAAGRRVPEDVAIVG
                     FDDNPKLAPAADPPLTSVHQEPAEQVKQMVDMLLDLLAGQTPEERRRVLPVSLAVREST
                     KG"
     gene            complement(7818..8867)
                     /locus_tag="B9C43_RS17570"
                     /old_locus_tag="SAMN05661093_03576"
     CDS             complement(7818..8867)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783389.1"
                     /locus_tag="B9C43_RS17570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03576"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_084427586.1"
                     /transl_table=11
                     /translation="MSELTSPTAPAEKTSETLLSVSGLQKYFPIRKGLLQRVQGHVQAV
                     DGLNFSVQKGETLSLVGESGCGKTTTGRLLTRLLEPTAGKIVFEGEDITHMSQSKMRPL
                     RRDVQMIFQDPYSSLNPRHTVGAIVGAPFKLQKVQTENGVKKAVQELLELVGLSPEHYN
                     RYPHEFSGGQRQRIGIARTLALKPKLIVADEPVSALDVSIQAQVVNLLEDLQNELDLTY
                     VMIAHDLSVVRHVSDRVAVMYLGKIVELGDRTGVYEKPMHPYTMALLSAVPVPDPERKA
                     KRERIRLKGDVPSPINPPSGCRFHTRCWKAQEICKTEEPELRELAPGRRAACHFPENTP
                     DSDHTVKVV"
     gene            complement(8872..9960)
                     /locus_tag="B9C43_RS17575"
                     /old_locus_tag="SAMN05661093_03577"
     CDS             complement(8872..9960)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683935.1"
                     /locus_tag="B9C43_RS17575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05661093_03577"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_033391268.1"
                     /transl_table=11
                     /translation="MGRTPDTELTGDEQATADAALNLPSAFLEVRDLRVHFPTDDGVVK
                     SVDGLSFSLERGKTLGIVGESGSGKSVTSLSIMGLHKQGSARITGEIRLNGEDLVSADP
                     ETVRRKRGKNMAMIFQDPLSAMHPYYTVGNQIIEAYRVHHNVSKAAARKHAIDMLDRVG
                     IPQPDKRVDDYPHAFSGGMRQRAMIAMALVCDPELLIADEPTTALDVTVQAQILDLIVD
                     LQKDFNSAVIIITHDLGVVAELADDIMVMYAGRSVEYGSAHEIFSSPQHPYTWGLLGSM
                     PRLDRERTERLQPIKGTPPSLINVPTGCPFNPRCAYGELNGDLSTTERPEFREISPGHR
                     IACHLSGEDRQRIWNDEIKPKL"
ORIGIN
        1 gccgccgccg atcgatccgt acgacacgaa gccgatcggc ttcgcgcgcc actggctcca
       61 gtgccagtcg acgaaagcct tgagggaagc cggaaagctg tggttgtact ccggcgtgac
      121 gatcacgaag gcgtccgcgt ccgcgagaac ctcagtggcc gcggccaacg ccgacggccg
      181 tgccggttcg gccatggcgg gtggttgcgg cggcatcacc agaggcagtt cgacctcggc
      241 gaggtcgatc acggagatct cgaactgacc gtgctgccgg gcgtagtcca cgaaccagtc
      301 ggtgatcagc gggccgcggc ggccttcccg cacgctgccc acgatcacgg cgagtttcat
      361 ctgagccatg aaggtaaagt acaacgtgca tggcaaattt gtaaaacggt cgttgtatcc
      421 ataggaggtc gagtggtccg ggcggacaag cgggaagcgg tcatgcaggc ggcgatgaag
      481 gtgttcggcc aggtcggcta cctgcttgcg agcatcgacg tgatcgcggc cgaagcgaat
      541 gtgtcgacca ggaccatcta caaccacttc gacaacaagg agaagctgtt cgccgaggtg
      601 ctgctgacca gttcacgtca ggtggccgag gcgcacgagg cactcatcga ccgcaacctc
      661 aacgacgcca ccgatctgga aacggcgctg gtgaacctcg cggaggactg gaaccggccg
      721 accccccaac tcgccgacca cttcgcgctg agcagcagga tggccgccga gcgggagcac
      781 ttccccaagg agatctacga agcctggcgg gaaaccgggc cgtggcgggt gcagcgcgca
      841 ctggcgtcga agttcgacga actacgtgac cagggcaaac tggatatgcc cgacaccagg
      901 ttcgccgccc atctgctgag cgtgatgttg accgagggca gggactacaa gcaagtcgtg
      961 cacgcgttcc tgtacggcta cgtgcctagg cgaagcgccg gatgatcttg gccaggacac
     1021 ttgcggcgat cagccagaac aaggccgcga tgccgtagtt gaccagcacg aacgccttcg
     1081 ggtcgctcgg cgtgaacaga tcacggaacc cgagggcgag cggatccgcc caggaggcga
     1141 agaaactcgt gatcccgttg ttcggattgg cgttgccgac ggtcagcagg atgtgaatga
     1201 ccaggatcaa cgtgcacagc aggccgaccc atcggaccac actggccacg atgccaacga
     1261 cctgcgcacg agtgaccccc gcgctctcgg acgagcgccc tgattcggcg tgctgggcca
     1321 tgtcaggagt ctggcacggc ccagcagctt tggctacttc ccagtaacaa accgttaccg
     1381 gccaatgatt cgcgccagga tcgacccgat gaccagccag aacacgcctg cgaggccgta
     1441 gttcagtatc acgtccaggt tgtagttacc cgtcgcgaac aggccaggga agaacagcgc
     1501 cagcggttcg gcgagcgact ggatgaacgt gaagaagccg ttcgtggtgt tcgcatccag
     1561 gacgatcagc aggatgtaca cggcttcgat cagtgcgaag atcgccgtga ccccgaacac
     1621 aacccgagcc gccgttcccc gcccgctcgt gacatgccat ctgcgagtag tcatatcttg
     1681 gggttcacct cggcgggcac ccggaaaccc cgctgaacgg agtaacccgc tccgcccagc
     1741 atgtgggacg cctggtttac ggatcagggg gtcggctcgc tactgtggtg ccgtggctcg
     1801 atccctcctg cttcgctgcc gcgacggggc ctgacgaaag accggctccc cgccgcggag
     1861 ctcagcgttg ccgccggtcg tccgctgatg aagctggaga cctctttcga tgaccacaaa
     1921 tcccgattcg ttccgctcgt cccggatccg caagcccgcg cgcccggcgc ccgccgacca
     1981 gccggtatgg aacgcccaac tcggttcctc gatgccggta caccggtacc ggccgttcgc
     2041 cgaggtggtc gaggacgtga cgctggccga ccggacgtgg ccggacaaca agatcaccac
     2101 ggccccgctg tggtgcgcgg tcgacctgcg cgacggcaac caggcgctga tcgacccgat
     2161 gtcgcccgcc cgcaagcgcc ggatgttcga gctgctggtc aagatgggct acaaggagat
     2221 cgaggtcggt ttccccgcgg ccagccagac cgacttcgac ttcgtccgcg agatcatcac
     2281 cgaggacgcg gtccccgagg acgtacgcat ccaggtgctg acgcagtgcc gtcccgagct
     2341 gatcgaacgc accttcgagg ccctgcaggg cgcgaacaag gcgatcgtgc acatctacaa
     2401 ctccacctcg atcctgcagc gccgcgtggt cttccgcgag gagcgcgagg gaatcaagaa
     2461 gatcgccacg tcggccgcgg aaatggtggc cgagctggcg gacaagtaca ccgacaccga
     2521 cttccggttc gagtactcgc ccgagtccta caccggcacg gaactgtcct acgccgccga
     2581 ggtctgcaac gccatcacgg agatctggca gcccacgccg cagcggccgg tgatcctgaa
     2641 cctgcccgcg accgtggaaa tggccacgcc gaacgtgtac gccgactcga tcgagtggat
     2701 gcaccgcaac ctggaacgcc gcgactcggt gatcctgtcg ctgcacccgc acaacgaccg
     2761 cgggaccggc gttgccgctg ctgaactggg ttatcaggcc ggagcggacc gcatcgaggg
     2821 ctgcctgttc ggcaacggcg agcgcaccgg caacgtctgc ctggtgacgc tgggcatgaa
     2881 catgttcagc cagggcatcg acccgcagat cgacttctcc gacatcgacg agatccgccg
     2941 gacggtcgag tactgcaacc agctgccggt ccccgagcgc cacccgtacg gcggtgacct
     3001 ggtgttcacc gcgttctccg gcagccacca ggacgccatc aacaagggct tcgacgcgct
     3061 gcgcgatgcc gcagacaagg cgggcacccc ggtcgaccag ttcgagtggg aagtcccgta
     3121 cctgccgatc gacccgaagg acgtcggccg cacgtacgag gccgtgatca gggtgaactc
     3181 gcagtccggc aagggcggcg tggcgtacgt gatgaagacc gaacaccagc tggagctgcc
     3241 gcgcaggctg cagatcgagt tctccggcgt ggtgcagaag atgaccgaca gcgagggcgg
     3301 agaggtcagc ccggcccaga tgtgggacat gttctcggcc gagtacctgt cggcgacgtc
     3361 cccgctgacg cttcagcggc accggctgtc cgacgacggc cacggccacg acgagatcgc
     3421 cgcggtcgtg cacgtcgaag gcgacgagca cgaggtcagg ggcaacggca acggcccgat
     3481 cgcggccttt gtggacgcgc tggccagcgt gggcttcgac gtccgggttc ttgactacac
     3541 cgagcacgcc ctcaccgcgg gtgacgacgc gcgcgccgct gcctacgtgg agtgcgcggt
     3601 cggagaccgt gtgttgtggg gtgtcggcgt cgactcgtcg atcgtgacgg cgtcactgcg
     3661 tgccgtcgta tcggcggtca accgagcaaa tcgatagagc tcagggaatc gggctggtca
     3721 ggcatgctga ccatgatccc gatcccgatc gcgaccgcga tcaggccggc gatgacaccg
     3781 atggcggcca tcccgccatc ggtggcccgg cccttgcgcg cgcgaatgac tccgatgacc
     3841 ccgaaaagca cggcgagtgc cccgaaaacg gttgcgagca gaccgaacaa cacggacagc
     3901 ccgaacccga tgccgacgat gcccaaagcg agggcagtcg tggcgaaacc attgcggaag
     3961 atcggcgtag cggcctctgg cggccggatc gcggcgctca tgggcaactc ccgtgcggaa
     4021 gggtccaggt tggacgcttg gcccataaat cgatgttatc cacgatcgtg ttaccgagtc
     4081 gcgaccatgt caacctattg gcgtacaagg gaaaacaccc tgtgtacgac ccattgcgca
     4141 gcgttgtgac ttgaccgatt ccgggaagct actcgtacgt gtagtgcgag gaatggtcca
     4201 gcatgtcgcg tggtgtgaca tcaccccacg gctgcatcac ctcgtcaatg tccacgacgt
     4261 tggctgtccc ggcgaccggt atgtaggtat ttctgccgtt gcggatctgc caatcggacc
     4321 acagcttgtc gacatggcaa tggtgtagcc agaacacggg atcattcggc gatcccgccc
     4381 ccgccatcgt gccgttaacc catacgtgta cccggttgtg caggttcggg ccgcggaaac
     4441 cctcaaggcc attgcgaaag ctcccggccg acgtgctgtt ccacggcgcg gtgtcgtacg
     4501 tgcggatgtc cagcacagtc cggacatccc gagccgtcgg cagcgaaacg ccgcctgagc
     4561 caaagcttcg gcgcaggaac ccggctgaat cgctgcgtac ggacagcggc cagctggatc
     4621 ccgcgaacgg accactggtg acccggccgt tctgtgacgg actcccgttg gggcccatga
     4681 agtccgttgc ccacaaggat gatccggcac ctgccgtggt ccagtcccag tacggcaggc
     4741 tgaccgtcgg atcgacggcc tgcagcgcac gttcgaagtc caacaggaat ttccggtgcc
     4801 acggaaggaa agacggcgac cggtgaccga ttctggtgcc gttgtcgctg tcgccgttca
     4861 gccggtcgat gtgctggcgg acaaaggtgt cgtagacgcc ggactgtttg atcgccagca
     4921 acgcgttgac cagattggtt ttctcggtcg cggtcaggtt ttgctggttc ttgcgaacgc
     4981 ccatggatgc tccccccttc tcagtgcacg tgcgtgaccg ggcgcaggtc gccgagggtg
     5041 tcgacggcgc gccgggccgc gtcgcgcagc gacgtgaacg actcgtagtg gttgatcgag
     5101 gtgctgtacg agccgtcgcc gttgcgcatc acgtgcacga cgtcgccgtc gacaaagatg
     5161 agttcgccct tgccgtggat ccggcggccc gcgtagatct cgtcgaagtc ggtttgcgcg
     5221 gcgagggcgt tccagccgac gaccgccccg ccagccaccg cggctgcccc ggtcatcagc
     5281 agtttccgtc tgctcaacat gacatcgacg ctatcgactg tgccacggga taagccgccg
     5341 ccaagtagcg gaaaaccttt ggtcataggc aaatgcgatg accagacggc cagataggag
     5401 gctagaaagg gctttctgtg cggttgttca ctgtaacgtt ggttaaccgc cgaatcaacg
     5461 ccgaagccgg ttcgcgccag tacagcacgg tccgccgacg cactggattg cattgcagcg
     5521 gacgaagaac caagccgtct ggtgcgctgc gggtgaacaa tccgactgcg cgcccggaac
     5581 gcacgacaag gcgagccgcg ctgggatcgg cgacccagta ccggatccgt ggctcgaacc
     5641 ccgcttgctg acaggccagt cgcagaccgc tgtcgccgaa cggagtgtca acccagtcgt
     5701 tgtcggaaag ctcggacagt ccgatgtgag gccggtcagc caacggatgg acccgcgaaa
     5761 gcccgattgc atacggctcg tcggcgacca ccttcctgtg cacgccgtcc ggcaccgaaa
     5821 acccggcagg ctcaacagag acgcacacgt ccaacgaacc cgcactcagt tgctgcagca
     5881 gccagtcggc cgaatgatcc acgcgcactt cgacgtccct gggcagcagc gggatcaacg
     5941 cgagcatcgt cgggcatggc tgccccgcga tccgcagccg atccgcgcca cctgcgacgc
     6001 tgcgggccga cgacaccaac tggtccatgt ccgccgccaa cgtccgcgcc ttgaccaaca
     6061 cccaatcacc caacggcgtg gtgcgtacgc cctcggctga tcggtggaac aattccccgc
     6121 cgaagtactt ctcgatccgc cggacgttgc cgctgacgcc cgcctggctc tgaccgagcc
     6181 ggatcgccgc cctgccgatg ctgccgcact ccgccacggc gatgatggtc ttcaaatgtc
     6241 cctgtccgag ctccataatg cttcagatct tctcgtgaaa tggcctgttt gcgacagtat
     6301 ctttcgaccc ctctggctta tgctctacag gtggggtcaa ctcaagaccg gccgacgctc
     6361 gaggatgtcg cggcatacgc gggggtatcc cgctcgaccg cgtcgcgcgc gctgaacgag
     6421 gaaatgtacg tcagtccgag ggctcgggag gcggtactcg cggccgcgcg agatctcgga
     6481 tactccccga accaggcggc ccgctcattg gtcaccaaac ggacaggagc ggtcgcgctg
     6541 gtcctgtcgg aaccggaatc gaaggtcctc gacgacccgt acttcctgat cgtgatgcgg
     6601 gcggcattcc gcgaactggc gaaccgaggc agccagatgc tggtgatgtt cgtcgacgcc
     6661 cccgacgaca tcccccgcac gatgaagttc ctcgacggcg gccacgtcga cggagcactg
     6721 gtcttcgccc cgcacagcgg cgacccgttg ccggtcgcgc tgaaactact gcgagtccca
     6781 gtggtcttcg gcggccgccc aggccgatcg agctcagacc tgtacacagt ggactacgac
     6841 aacaccgcag gcgcccagct cgcggtggag cacctgctga gtgtcggtaa gcggaacatc
     6901 gtgaccgtct gcggcccgca ggaccacccc gcagcgatgg accgattgac cggctggcga
     6961 gaaacccttg cagagaaagg gatgccgacc aacggccgcg ccgagaacgg cgacttcacc
     7021 caaaccggcg gcgaagcggc aatggtcaag ctgctggaac gcgaacccga cctggacgca
     7081 gtgttcgccg ccagcgaccc gatggcaatc ggcgcgctgc gagcactgaa ggccgcgggg
     7141 cgtcgagtcc ccgaagacgt ggcgatcgtg ggcttcgacg acaacccgaa actggcgcca
     7201 gccgccgacc caccgctgac ctcggtgcac caggaaccag ccgagcaggt caagcagatg
     7261 gtggacatgc tgctggactt gcttgcgggc caaactccgg aggaacgtcg ccgggtgctg
     7321 ccggtgtcgc tggcagtccg ggagtccaca aagggctagc gggtcatctg gtcagccggg
     7381 ccaagtcctg gagcgcgccc gaagaacgaa cagcgaaggc gcgccaaaag caaagcggag
     7441 gcgtccctag cccaaaggcg cacccgaaga acagtggagg cgcgccccag cccaagcgaa
     7501 ggcgcgcccg gagcacgaag aggcgcgcca aaagtggtag tcggcgcgat tttgtgtgga
     7561 gtggcgccgc aaataagctt gtcggcgggg cagggccgca ggtcctgccc gctttccctg
     7621 ccttttgcgg cgcagaggct ccacaccaaa tcgcgccgac cagtcacagg agcgcgccga
     7681 aagcaaccac agagcgcgcc gtggcgacca aagagcgcgc cgcagtaggc acagcgcgcc
     7741 gcagtgagcc aagcgcgccg aaaacaaccc cagcaccgcc actagaaggc ccccgtcaac
     7801 gacgagggcc cttgtcacta caccactttg acagtgtggt cggagtccgg tgtgttctcc
     7861 gggaaatgac acgcggcccg gcgacccggc gccagctcac gcaactccgg ctcctccgtc
     7921 ttgcagatct cctgagcctt ccagcacctc gtgtggaacc ggcagccgga cggcgggttg
     7981 atcggcgacg gcacgtcgcc cttcaaccgg atccgctccc gtttggcctt gcgctccggg
     8041 tccggcacgg gcaccgccga cagcaacgcc atcgtgtacg ggtgcatcgg cttctcgtac
     8101 acgccggtcc ggtcgccgag ctccacgatc ttgcccaggt acatcaccgc gacccggtcc
     8161 gacacgtgcc gcaccaccga caggtcgtgc gcgatcatca cgtatgtcag gtccagctcg
     8221 ttctgcagat cctccagcag gttcaccacc tgcgcctgga tcgacacgtc caaagcggac
     8281 actggctcgt ccgcgacgat cagcttgggc ttcaacgcga gcgtgcgggc gatcccgatt
     8341 ctttgccgct gcccgccgga gaactcgtgc gggtaccggt tgtagtgctc cgggctcagg
     8401 ccgaccagtt cgagcagttc ctgcacggcc ttcttcacgc cgttctcggt ctgcaccttc
     8461 tgcagcttga acggcgcgcc gacgatcgcg cccacggtgt gccgcgggtt cagtgacgag
     8521 tacgggtcct ggaagatcat ctgcacgtcg cggcgcagcg ggcgcatctt cgactgtgac
     8581 atgtgggtga tgtcctcacc ctcgaagacg atcttgccgg cggtcggctc gagcagccgg
     8641 gtcagcagcc gtcccgttgt ggtcttgcca cagccggact cgccgaccag ggagagcgtc
     8701 tcgcccttct gcaccgagaa gttcagcccg tcaacggcct gcacgtgccc ttgcacccgc
     8761 tgcagcaggc ctttgcggat cgggaagtac ttctgcagtc ccgacaccga cagcagggtc
     8821 tcgctggtct tctcggcggg cgcggtggga gaggtcagtt cgctcatcga ctcacaactt
     8881 cggcttgatc tcgtcgttcc agatccgctg gcggtcttcg ccagacagat ggcacgcgat
     8941 ccggtgtcca ggactgatct cgcggaactc cgggcgctcg gtcgtgctga gatcgccgtt
     9001 gagctccccg taggcgcacc tcgggttgaa cgggcagccg gtcgggacgt tgatcaggct
     9061 gggcggggtg cccttgatcg gctgcagccg ctcggtgcgt tcccggtcaa gccggggcat
     9121 cgaaccgagc aggccccacg tgtacgggtg ttgcggcgac gagaagatct cgtgcgcact
     9181 gccgtactcc accgagcggc ccgcgtacat caccatgatg tcgtcggcca gctcggcgac
     9241 cacgccgagg tcgtgggtga tgatgatgac cgcggagttg aagtccttct gcagatccac
     9301 gatcagatcg aggatctgcg cctgcacggt cacgtccagc gcggtggtcg gctcgtccgc
     9361 gatcagcagc tccgggtcgc acaccagcgc catcgcgatc atcgcgcgct gccgcatacc
     9421 gccggagaac gcgtgcgggt agtcgtcgac ccgcttgtcc ggctgcggaa tgcccacgcg
     9481 gtcgagcatg tcgatcgcgt gcttgcgggc cgccgccttg gacacgttgt ggtgcacccg
     9541 gtaggcctcg atgatctggt tgccgaccgt gtagtacggg tgcatcgccg acagcgggtc
     9601 ctggaagatc atcgccatgt tcttgccgcg cttgcggcgc acggtttcgg gatccgcgct
     9661 gaccaggtcc tcgccgttca gcctgatctc gccggtgatg cgagccgagc cttgcttgtg
     9721 cagccccatg atcgacaggc tggtgacgct cttgcctgag ccggactcgc cgacgatgcc
     9781 gagcgtcttt ccccgctcga ggctgaacga cagcccgtcg acggacttga ccacgccgtc
     9841 gtcggtcggg aagtgcacgc gcaagtcgcg cacctcaagg aaagccgacg gcaggttcaa
     9901 cgcggcgtca gccgtggctt gctcgtcacc ggtcagctcg gtgtctgggg ttcgccccat
     9961 cagctaacgc ctcacagtcg ggtcgaggac gccgtacagg acgtccacca ccaggttggc
    10021 cagaacgatg aacagcgcgg cgaacatgac cacgccgagc accatgggca ggtcactctg
    10081 gatcaccccg tcgagtgcca gctgaccaag tcccttgagc gagaaggttt tttcggtgag
    10141 caccgcacca cccagcagca ggccgacgtc cagaccgaac acggtcagga tcggtgtcag
    10201 gctggcgcgc agcgcgtgct tgctgatgac ggtccgctca cgcaacccct tggctcttgc
    10261 cgtccggacg aagtcctcgc ccagggtgtc gagcatcccg
//
