LOCUS       NZ_FUWZ01000020         6765 bp    DNA     linear   CON 22-OCT-2024
DEFINITION  Chitinophaga eiseniae strain DSM 22224, whole genome shotgun
            sequence.
ACCESSION   NZ_FUWZ01000020
VERSION     NZ_FUWZ01000020.1
KEYWORDS    WGS; RefSeq.
SOURCE      Chitinophaga eiseniae
  ORGANISM  Chitinophaga eiseniae
            Bacteria; Bacteroidota; Chitinophagia; Chitinophagales;
            Chitinophagaceae; Chitinophaga.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-FEB-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900167135.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 16:06:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,843
            CDSs (total)                      :: 6,771
            Genes (coding)                    :: 6,741
            CDSs (with protein)               :: 6,741
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1, 1 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 30
            CDSs (without protein)            :: 30
            Pseudo Genes (ambiguous residues) :: 0 of 30
            Pseudo Genes (frameshifted)       :: 2 of 30
            Pseudo Genes (incomplete)         :: 28 of 30
            Pseudo Genes (internal stop)      :: 1 of 30
            Pseudo Genes (multiple problems)  :: 1 of 30
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:38:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 6765
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FUWZ01000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..6765
                     /db_xref="taxon:634771"
                     /mol_type="genomic DNA"
                     /note="contig: Ga0070509_120"
                     /organism="Chitinophaga eiseniae"
                     /strain="DSM 22224"
                     /type_material="type strain of Chitinophaga eiseniae"
     gene            <1..>6765
                     /locus_tag="B5D63_RS34430"
                     /old_locus_tag="SAMN04488128_1201"
     region          1..6765
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..6765
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..6765
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[4:>6765](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5..>6765
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS             5..>6765
                     /NRPS_PKS="Domain: PCP (250-319). E-value: 3.4e-23. Score:
                     73.6. Matches aSDomain: nrpspksdomains_B5D63_RS34430_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (333-635). E-value:
                     1.8e-97. Score: 317.9. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34430_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (806-1200). E-value:
                     5.7e-111. Score: 362.9. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34430_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1308-1375). E-value: 5.2e-26.
                     Score: 82.6. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34430_PCP.2"
                     /NRPS_PKS="Domain: Condensation_LCL (1391-1693). E-value:
                     1.8e-99. Score: 324.5. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34430_Condensation_LCL.2"
                     /NRPS_PKS="Domain: AMP-binding (1864-2091). E-value:
                     4.3e-59. Score: 192.0. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34430_AMP-binding.2"
                     /codon_start=3
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF003417.0"
                     /locus_tag="B5D63_RS34430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1201"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_143313382.1"
                     /sec_met_domain="AMP-binding (E-value: 2.8e-119, bitscore:
                     384.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.5e-16, bitscore:
                     45.2, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 4.2e-83, bitscore:
                     264.9, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDTIPDTLLQKLSSIFRKAEIVVTYGPTEGTIFCTAVSYDISAG
                     VLPASGACIGRPLPGSTIYILDKDHQLLPAGVMGEICIGGAGVSAGYFGQPELTSEKFV
                     PDPLISGGRIYCSGDLGRWNEKGEVVFMGRRDTQVKIRGFRIETGEIERALLSHEDIRE
                     AVVMAREDGTGSRYLAAYLVTDKPCPPSTVRSYLSGLLPDYMLPGYYISLPQLPLTGNG
                     KIDRQSLPVPGAGDASRSEAYVPAGTETEERLVKIWEEVLGQTGIGIYDNFFEAGGHSL
                     KAIQLVSRIKQVFEAKILLADIFTCPDIASQATYLEHASGQAFAAIPRVADQESYPLSH
                     AQRRLWILSQFSDGSAAYNVTGFLLFDGVLVPSLLEKVLRYVAGRHESLRTVFREDASG
                     VVRQYVLPVDKLTWAPLCVDISSLPDAAAALREIFSVEQHTRFDLGQGPLIRTKVVKVS
                     EQQFALFYTMHHIISDGWSMEVLSRDVITAYNHFREGSEPALAPLPLQYRDYAAWQSSG
                     KDTAAFRAHERYWLEQLSGELPVLDLPADKRRPAVKTHPGSSVTVSLPSSVMGALTALC
                     HKEGATLFMGLLAALKALFFRYTGQEDIIVGSPVAGREHQDLEDQIGLYVNSLALRTRF
                     SGKDTFASLLAKEKQVLLDAYAHQSYPFDMLIEKLPLPRDRSRLPLFDIMVGMQNQVST
                     NVYDKTVGLDGLSRRETDEMKQERSQFDLLFSFVEAPGGWDLSLTYNTDIYSERNVNAL
                     CAHYLQLLHEVTLRPQEAIDGITYLSAAEQQLLLNTFNDTAFSFGEKQTLHQRFEQQAA
                     QTPDRPALIQGDRQLTYRELNERSNQLAHYLRNTYSILPGDLVAIIADRSELVIIGILA
                     VLKAGAAYVPVDPSYPQERIRFMLEDAAPKLVLTFSDRLFEMIDYYTGALFALDVQLES
                     LHESVDNPEGLADPSSLAYVIYTSGSTGQPKGVMVAHSGVVNMSLDQVRQFEVQADDKV
                     LQFASLSFDASVSECFLAFFSGASLVMISEAILRERELFIQYLRQHQITVITLPPAYLQ
                     LFSEEELSGLRILITAGQEADKATALRFSKKLNYYNAYGPTENSVCATIYKVDPAIPLP
                     AGVPIGKPIANNRIFILDDRGQLLPVGIPGEICIGGEGLALGYLHNNGLTAARFIENPY
                     RKNERLYRTGDIGRWDAEGNLLFLGRNDQQVKIRGYRIELEEIEQTLLQYPGITHAVVQ
                     MRKEPTGEGSYLAAFIVAPAMPDREAMTSFMAARLPEYMVPAVFMQLAALPLTHNGKVD
                     RKALPDPLAADKSGEQFVAPAGTLEIQLASLWQEVLGREQVGRNDHFFLLGGHSLKAMQ
                     LLSRIRSLFQLEVELNDLFTYPVLHEQAAFLGVAAPRNIIEIPKAPLQESYPLSHAQQR
                     FWILSQFEEASAAYNVPGVCVLEGPLSKTLLEEAIELLWRRHESLRTVFREDAAGNIRQ
                     YILDAGEQPADMVYEDISHEKDIMERLQQMFIEAQQAPFDLRQGPLLRIKVVKLHDAAH
                     ALLYTMHHIISDGWSLQVLIKEMTTVYNALKEGVSPVLPALPIQYKDFAVWQASGNNDS
                     HLEKHRAYWLEQLSGPIPVLDLPAEKGRPSVKTHHGATIGCMLPATTVHALLQLCREEE
                     ASLFMGLLAGLKALLHHYTGQEDIIIGSPIAGRDLKELENQIGLYLNTLPLRTRFTATD
                     TFRALLQQEREVLLAAYRHQVYPFDLLVNQLQLERNTSRSPLFDVLVIMQNQSSVAGNG
                     NTGGMSGLQWRQPEGMQRVTSQFDLEFSFMETGDSVEVLLNYNTDIYSASFVRNLLTHL
                     ELLLAFAAGHPEHALGVLDYLTSAEKMQQLSAFNNTTNDFPQTESIVSLFRRQALLRPE
                     ETAVVFEDSALTYRELDERSDQVARLLTEQLQVQPGALVVLLTERSVHLMAGMLGILKA
                     GAAYVPLDPAYPAERISYVLEDCGARVLVAGEGTALPAGYDGAVLQLETAVNDDNDAGY
                     TPHAVLPEDLCYVIYTSGSTGRPKGVMVNHRNVVNFFSAMDREVPLQEDDCLLAMTSTS
                     FDISVLELLWTLCRGVQVVIHPSDRIPGNLDRYTEKAPATVDFSLFFFSSYDHGSANKY
                     DLLQSSVRYADEHGFRAVWTPERHFHEFGGLYPNPSVIGAALAVSTRRLEIRSGSVVAP
                     LHDTVRIAEEWAVVDNLSGGRVGLSFAPGWNANDFVLSSAPYASRHQRMYEQIAEVRHL
                     WEGGSITRTNGFGQEVSLQVYPRPVQ"
     CDS_motif       82..105
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0001"
                     /evalue="7.10E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="33"
                     /protein_start="25"
                     /score="3.5"
                     /tool="antismash"
                     /translation="YGPTEGTI"
     CDS_motif       226..315
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0002"
                     /evalue="6.80E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="103"
                     /protein_start="73"
                     /score="44.0"
                     /tool="antismash"
                     /translation="PAGVMGEICIGGAGVSAGYFGQPELTSEKF"
     CDS_motif       397..462
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0003"
                     /evalue="1.60E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="152"
                     /protein_start="130"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FMGRRDTQVKIRGFRIETGEIE"
     CDS_motif       670..696
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0004"
                     /evalue="9.80E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="230"
                     /protein_start="221"
                     /score="3.1"
                     /tool="antismash"
                     /translation="GKIDRQSLP"
     aSDomain        757..963
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34430_PCP.1"
                     /evalue="3.40E-23"
                     /label="B5D63_RS34430_PCP.1"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="319"
                     /protein_start="250"
                     /score="73.6"
                     /tool="antismash"
                     /translation="EERLVKIWEEVLGQTGIGIYDNFFEAGGHSLKAIQLVSRIKQVFE
                     AKILLADIFTCPDIASQATYLEHA"
     aSDomain        1006..1911
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34430_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.80E-97"
                     /label="B5D63_RS34430_Condensation_LCL.1"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="635"
                     /protein_start="333"
                     /score="317.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIISDG"
                     /tool="antismash"
                     /translation="ESYPLSHAQRRLWILSQFSDGSAAYNVTGFLLFDGVLVPSLLEKV
                     LRYVAGRHESLRTVFREDASGVVRQYVLPVDKLTWAPLCVDISSLPDAAAALREIFSVE
                     QHTRFDLGQGPLIRTKVVKVSEQQFALFYTMHHIISDGWSMEVLSRDVITAYNHFREGS
                     EPALAPLPLQYRDYAAWQSSGKDTAAFRAHERYWLEQLSGELPVLDLPADKRRPAVKTH
                     PGSSVTVSLPSSVMGALTALCHKEGATLFMGLLAALKALFFRYTGQEDIIVGSPVAGRE
                     HQDLEDQIGLYVNSLALRTRF"
     aSModule        1006..4131
                     /complete
                     /domains="nrpspksdomains_B5D63_RS34430_Condensation_LCL.1"
                     /domains="nrpspksdomains_B5D63_RS34430_AMP-binding.1"
                     /domains="nrpspksdomains_B5D63_RS34430_PCP.2"
                     /locus_tags="B5D63_RS34430"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1012..1047
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0005"
                     /evalue="4.60E-02"
                     /label="C1_starter_004-017"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="347"
                     /protein_start="335"
                     /score="7.1"
                     /tool="antismash"
                     /translation="YPLSHAQRRLWI"
     CDS_motif       1072..1188
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0006"
                     /evalue="6.50E-10"
                     /label="C2_LCL_024-062"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="394"
                     /protein_start="355"
                     /score="31.4"
                     /tool="antismash"
                     /translation="AAYNVTGFLLFDGVLVPSLLEKVLRYVAGRHESLRTVFR"
     CDS_motif       1408..1473
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0007"
                     /evalue="1.80E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="489"
                     /protein_start="467"
                     /score="33.2"
                     /tool="antismash"
                     /translation="MHHIISDGWSMEVLSRDVITAY"
     CDS_motif       1522..1551
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0008"
                     /evalue="7.20E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="515"
                     /protein_start="505"
                     /score="12.3"
                     /tool="antismash"
                     /translation="QYRDYAAWQS"
     CDS_motif       1813..1902
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0009"
                     /evalue="2.10E-13"
                     /label="C5_LCL_267-296"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="632"
                     /protein_start="602"
                     /score="42.6"
                     /tool="antismash"
                     /translation="DIIVGSPVAGREHQDLEDQIGLYVNSLALR"
     CDS_motif       1951..2070
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0010"
                     /evalue="6.20E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="688"
                     /protein_start="648"
                     /score="50.7"
                     /tool="antismash"
                     /translation="KQVLLDAYAHQSYPFDMLIEKLPLPRDRSRLPLFDIMVGM"
     aSDomain        2425..3606
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34430_AMP-binding.1"
                     /evalue="5.70E-111"
                     /label="B5D63_RS34430_AMP-binding.1"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1200"
                     /protein_start="806"
                     /score="362.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEQQAAQTPDRPALIQGDRQLTYRELNERSNQLAHYLRNTYSILP
                     GDLVAIIADRSELVIIGILAVLKAGAAYVPVDPSYPQERIRFMLEDAAPKLVLTFSDRL
                     FEMIDYYTGALFALDVQLESLHESVDNPEGLADPSSLAYVIYTSGSTGQPKGVMVAHSG
                     VVNMSLDQVRQFEVQADDKVLQFASLSFDASVSECFLAFFSGASLVMISEAILRERELF
                     IQYLRQHQITVITLPPAYLQLFSEEELSGLRILITAGQEADKATALRFSKKLNYYNAYG
                     PTENSVCATIYKVDPAIPLPAGVPIGKPIANNRIFILDDRGQLLPVGIPGEICIGGEGL
                     ALGYLHNNGLTAARFIENPYRKNERLYRTGDIGRWDAEGNLLFLGRNDQQVKIR"
     CDS_motif       2614..2655
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0011"
                     /evalue="9.70E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="883"
                     /protein_start="869"
                     /score="18.7"
                     /tool="antismash"
                     /translation="LAVLKAGAAYVPVD"
     CDS_motif       2848..2907
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0012"
                     /evalue="1.40E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="967"
                     /protein_start="947"
                     /score="32.9"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGQPKGVMVAH"
     CDS_motif       3262..3288
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0013"
                     /evalue="1.60E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1094"
                     /protein_start="1085"
                     /score="5.4"
                     /tool="antismash"
                     /translation="YGPTENSVC"
     CDS_motif       3400..3489
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0014"
                     /evalue="1.00E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1161"
                     /protein_start="1131"
                     /score="43.4"
                     /tool="antismash"
                     /translation="PVGIPGEICIGGEGLALGYLHNNGLTAARF"
     CDS_motif       3571..3636
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0015"
                     /evalue="2.80E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1210"
                     /protein_start="1188"
                     /score="35.4"
                     /tool="antismash"
                     /translation="FLGRNDQQVKIRGYRIELEEIE"
     CDS_motif       3847..3873
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0016"
                     /evalue="1.40E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1289"
                     /protein_start="1280"
                     /score="5.3"
                     /tool="antismash"
                     /translation="GKVDRKALP"
     aSDomain        3931..4131
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34430_PCP.2"
                     /evalue="5.20E-26"
                     /label="B5D63_RS34430_PCP.2"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1375"
                     /protein_start="1308"
                     /score="82.6"
                     /tool="antismash"
                     /translation="EIQLASLWQEVLGREQVGRNDHFFLLGGHSLKAMQLLSRIRSLFQ
                     LEVELNDLFTYPVLHEQAAFLG"
     aSDomain        4180..5085
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34430_Condensation_LCL.2
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.80E-99"
                     /label="B5D63_RS34430_Condensation_LCL.2"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1693"
                     /protein_start="1391"
                     /score="324.5"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIISDG"
                     /tool="antismash"
                     /translation="ESYPLSHAQQRFWILSQFEEASAAYNVPGVCVLEGPLSKTLLEEA
                     IELLWRRHESLRTVFREDAAGNIRQYILDAGEQPADMVYEDISHEKDIMERLQQMFIEA
                     QQAPFDLRQGPLLRIKVVKLHDAAHALLYTMHHIISDGWSLQVLIKEMTTVYNALKEGV
                     SPVLPALPIQYKDFAVWQASGNNDSHLEKHRAYWLEQLSGPIPVLDLPAEKGRPSVKTH
                     HGATIGCMLPATTVHALLQLCREEEASLFMGLLAGLKALLHHYTGQEDIIIGSPIAGRD
                     LKELENQIGLYLNTLPLRTRF"
     aSModule        4180..6279
                     /domains="nrpspksdomains_B5D63_RS34430_Condensation_LCL.2"
                     /domains="nrpspksdomains_B5D63_RS34430_AMP-binding.2"
                     /incomplete
                     /locus_tags="B5D63_RS34430"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4186..4221
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0017"
                     /evalue="1.80E-01"
                     /label="C1_starter_004-017"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1405"
                     /protein_start="1393"
                     /score="5.3"
                     /tool="antismash"
                     /translation="YPLSHAQQRFWI"
     CDS_motif       4246..4362
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0018"
                     /evalue="4.30E-13"
                     /label="C2_LCL_024-062"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1452"
                     /protein_start="1413"
                     /score="41.7"
                     /tool="antismash"
                     /translation="AAYNVPGVCVLEGPLSKTLLEEAIELLWRRHESLRTVFR"
     CDS_motif       4582..4647
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0019"
                     /evalue="1.30E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1547"
                     /protein_start="1525"
                     /score="33.7"
                     /tool="antismash"
                     /translation="MHHIISDGWSLQVLIKEMTTVY"
     CDS_motif       4696..4725
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0020"
                     /evalue="3.20E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1573"
                     /protein_start="1563"
                     /score="13.4"
                     /tool="antismash"
                     /translation="QYKDFAVWQA"
     CDS_motif       4987..5076
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0021"
                     /evalue="1.60E-12"
                     /label="C5_LCL_267-296"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1690"
                     /protein_start="1660"
                     /score="39.8"
                     /tool="antismash"
                     /translation="DIIIGSPIAGRDLKELENQIGLYLNTLPLR"
     CDS_motif       5125..5238
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0022"
                     /evalue="2.00E-17"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1744"
                     /protein_start="1706"
                     /score="55.5"
                     /tool="antismash"
                     /translation="REVLLAAYRHQVYPFDLLVNQLQLERNTSRSPLFDVLV"
     aSDomain        5599..6279
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34430_AMP-binding.2"
                     /evalue="4.30E-59"
                     /label="B5D63_RS34430_AMP-binding.2"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="2091"
                     /protein_start="1864"
                     /score="192.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FRRQALLRPEETAVVFEDSALTYRELDERSDQVARLLTEQLQVQP
                     GALVVLLTERSVHLMAGMLGILKAGAAYVPLDPAYPAERISYVLEDCGARVLVAGEGTA
                     LPAGYDGAVLQLETAVNDDNDAGYTPHAVLPEDLCYVIYTSGSTGRPKGVMVNHRNVVN
                     FFSAMDREVPLQEDDCLLAMTSTSFDISVLELLWTLCRGVQVVIHPSDRIPGNLDRYTE
                     KAPAT"
     CDS_motif       5788..5829
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0023"
                     /evalue="5.40E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="1941"
                     /protein_start="1927"
                     /score="19.4"
                     /tool="antismash"
                     /translation="LGILKAGAAYVPLD"
     CDS_motif       6013..6072
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34430_0024"
                     /evalue="2.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="B5D63_RS34430"
                     /protein_end="2022"
                     /protein_start="2002"
                     /score="32.2"
                     /tool="antismash"
                     /translation="CYVIYTSGSTGRPKGVMVNH"
ORIGIN
        1 tcggcggcga tacgatcccc gatactttgc ttcagaagct gtcgtccatc ttccggaaag
       61 cggagatcgt ggttacctac ggtcctacag aaggaacgat cttctgcacg gcggtaagct
      121 acgatatcag cgccggtgtg ttgcctgcca gcggagcctg cataggccgg ccattgcccg
      181 gcagcaccat ctatatactg gacaaagatc atcagctgtt accggcgggt gttatggggg
      241 aaatctgtat cggcggcgcc ggcgtgtccg caggttattt tgggcaaccg gagctgacat
      301 cggagaagtt tgtgcccgat ccgcttatat cgggaggccg catctactgc agcggagatc
      361 tcgggcggtg gaatgaaaag ggagaggtgg tgtttatggg ccgccgcgac acgcaggtga
      421 agatacgcgg tttccgcatt gagacgggcg aaatagaacg tgccctgctc agtcatgaag
      481 acatccgcga agcggtggtg atggcccgtg aagacggtac gggaagcagg tacctggccg
      541 cctacctggt cacagacaag ccatgtccgc cgtccacggt acggagctac ctgtcgggtt
      601 tattaccgga ctatatgctg cccggttatt acatcagcct gccgcagctg ccgttaaccg
      661 gcaatggcaa gatagaccgc cagtcgctgc ccgtgccggg ggccggtgat gccagtcgca
      721 gtgaagccta tgtgcccgca ggtacagaaa cggaggagcg tttggtgaag atatgggaag
      781 aggtattggg ccagacaggg atcggtatct atgataactt ctttgaagca ggggggcaca
      841 gtctgaaagc tattcagctg gtgagcagga taaaacaggt gtttgaagca aagattctgc
      901 tggcggatat ttttacctgt ccggatatag cctcgcaggc gacatacctg gaacacgctt
      961 ccggacaggc gtttgccgct ataccgcggg tagccgacca ggaaagttac ccactcagcc
     1021 acgcgcagcg caggctctgg atattaagcc agttcagcga cggttctgcc gcctataatg
     1081 ttaccggttt ccttttgttt gacggtgtat tggtgccgtc attgctggag aaagtgttgc
     1141 gatatgtcgc cggccggcat gaaagcctgc ggacagtgtt cagggaggat gcttcgggag
     1201 tggtacgcca gtatgtgctg ccggtagata aactgacatg ggcaccgctc tgcgttgaca
     1261 tcagtagcct gccggatgct gcagcagcgc tgcgggaaat attctccgta gagcagcata
     1321 cgaggttcga cctcggccag ggaccactga taaggacgaa agtggtgaaa gtatcggaac
     1381 aacagtttgc gttgttttat accatgcatc atattatcag tgatggctgg tctatggaag
     1441 tgctgtccag ggacgtaatt acagcgtata atcatttccg tgaaggcagc gaacccgcgc
     1501 tggcgccgct gccgctgcag taccgggact atgccgcctg gcagtcgtca ggaaaagata
     1561 cagccgcttt ccgcgcgcac gaacgctatt ggctggaaca gttgtctggt gagctccctg
     1621 tgctggatct gccggcagac aaacgtcgcc cggcggtcaa aacacacccc ggcagcagtg
     1681 tcacggtgag tctgccgtct tcggtgatgg gcgctttgac agccctttgc cataaagaag
     1741 gcgctacgct ttttatgggg ctgctcgccg cgctgaaagc actttttttc cgctataccg
     1801 gacaggaaga tatcatcgtt ggcagccctg tggctggcag ggaacatcag gacctggaag
     1861 accagatagg gctgtatgtc aacagcctgg ctttgcgtac ccgctttagc ggaaaagaca
     1921 cttttgccag cctgctggca aaagaaaaac aggtgctgct ggatgcctat gcacaccagt
     1981 catatccctt cgatatgctg atagaaaaac tgccgctgcc cagggacagg agccgtctgc
     2041 cactgttcga tatcatggtg gggatgcaga accaggtgtc tacgaatgta tatgacaaga
     2101 cggtgggttt ggatggactt tcccggagag agacggatga aatgaaacag gaaagaagtc
     2161 agttcgacct gctttttagt ttcgtggaag caccgggcgg atgggacctc tcacttacct
     2221 ataataccga catttacagc gagcgcaatg tcaacgcgct ttgtgcgcat tatctgcagc
     2281 tgttgcacga ggtaacgctt cgtccgcagg aggcgatcga cggtataacg tacctgtccg
     2341 cagctgaaca acagctgctg ttaaatactt tcaacgatac ggctttttct ttcggcgaaa
     2401 aacagacgtt gcatcaacgg tttgagcaac aggcggcgca gacgccggac aggccggcgc
     2461 tcatacaggg cgacaggcag ctgacctacc gggaattgaa tgaacgctcc aatcagctcg
     2521 ctcactatct gcgcaatacc tattctatcc ttcccggcga cctcgttgct attattgcag
     2581 accgttcaga gctggtcatc atagggatac tggcagtact aaaagcagga gccgcctatg
     2641 tgccggtaga tccgtcttac ccgcaggagc gcatccgctt catgctggaa gacgcagctc
     2701 ctaaactggt gcttacgttc tccgatcgcc tgtttgaaat gatcgattat tataccggcg
     2761 ccttatttgc attggatgta caactggaaa gcctgcacga aagcgtggat aaccctgaag
     2821 ggctggcaga tccgtcctct ttggcctatg tgatctacac ttccggtagt accgggcagc
     2881 ctaaaggggt gatggtagcg catagcggcg tggtaaatat gtcattggac caggtgcgcc
     2941 agtttgaggt acaggcggat gacaaggtgc tgcaatttgc ttcactgtct ttcgatgcat
     3001 ctgtatcgga atgttttttg gcgtttttct ccggcgcttc actggtgatg atcagcgaag
     3061 cgatattgcg cgagcgcgaa ctgtttatac aatacctgcg gcaacatcag atcaccgtaa
     3121 ttaccctgcc acccgcttac ctgcaactct ttagcgaaga agagctgtcg gggctgcgga
     3181 tattgatcac agcgggacag gaagcagata aggctactgc gctccgcttc agtaaaaaac
     3241 taaactacta taacgcttac gggccaacgg aaaattctgt ctgcgccacc atctataaag
     3301 tagacccggc gatacccctg ccggcgggcg ttccgatagg caaaccgatt gccaataacc
     3361 ggatcttcat cctggatgac cgcggacaac tgctcccggt tggtataccg ggcgaaatat
     3421 gtatcggcgg cgaaggcctg gcgcttggct atcttcataa caacgggctg acagccgcca
     3481 ggttcatcga aaatccctac cggaaaaatg aacggttgta tcgtaccggt gatataggcc
     3541 ggtgggatgc ggagggcaat ctgctctttt tgggaaggaa cgaccaacag gtaaaaataa
     3601 gaggctatcg cattgagctg gaagagatag aacaaaccct gctgcaatac ccgggtatca
     3661 cccacgcagt ggtacaaatg aggaaagagc caaccggaga gggtagctac ctggccgcgt
     3721 ttatcgttgc cccggcaatg cccgatcggg aagcgatgac cagcttcatg gcggcgcggc
     3781 tgccggaata tatggtgccg gctgtgttta tgcagttggc ggcgctaccg ctgacccata
     3841 acggaaaggt agaccgtaaa gcgctgcccg acccgctggc ggcagacaaa tccggggagc
     3901 aatttgtagc gccggcgggt acgctggaaa tacaattggc ctccctgtgg caggaggtat
     3961 tgggaagaga acaggtagga agaaacgatc actttttcct gctgggcgga catagcctga
     4021 aagccatgca gctgttgagc cgcatccgta gcctgtttca gctggaagtg gaactgaacg
     4081 atcttttcac ttaccccgtt ctgcatgaac aggccgcttt cctcggcgtg gcagcgccgc
     4141 gcaacatcat tgagataccc aaagcgcctt tgcaggaaag ctacccgctc agccatgcac
     4201 aacaacgttt ctggatactg agccagtttg aagaagcatc ggcggcttat aacgttcccg
     4261 gcgtctgtgt cctggagggt ccgctgagca aaacactgct cgaagaggcc attgagctgt
     4321 tgtggcgccg ccacgagagc ctgcggactg ttttccggga agacgccgcc ggcaatatcc
     4381 gtcaatatat cctggacgcc ggcgagcagc ctgcagatat ggtttatgaa gatatcagcc
     4441 atgaaaaaga catcatggaa aggctgcagc agatgtttat cgaagcgcag caggctccct
     4501 ttgatctccg gcaaggccct ttgctccgca tcaaagtggt gaaactgcat gatgctgcac
     4561 atgcgttgct ctataccatg catcacatca tcagcgacgg atggtcactg caggtgttga
     4621 taaaggagat gaccaccgtc tataacgcgc tgaaagaggg cgtcagcccg gtgttacctg
     4681 cattgcctat ccaatacaaa gactttgcag tatggcaggc ctccggtaac aacgacagcc
     4741 acctggagaa acatcgcgct tactggctgg agcagttgtc cggccccata cctgtactgg
     4801 acctgcccgc ggagaaaggc cgcccgtccg tgaaaaccca tcacggtgct acgatcggct
     4861 gcatgctgcc cgcgacgacg gtacatgcgt tgctgcaact gtgccgtgaa gaagaagcct
     4921 ccctctttat gggcctgctg gctggattaa aagcattgct tcatcactat accggtcagg
     4981 aagatattat catcggcagc ccaattgcag ggagagatct caaagagctg gaaaaccaga
     5041 tcggattata tctgaatacg ctgccacttc gtacccgttt tacggcaaca gatactttcc
     5101 gggcactgct gcaacaggaa agggaagtgc tgctggctgc ctatcggcac caggtatatc
     5161 cttttgacct gctggtaaac cagttacagc tggaacgcaa taccagccgt tcacccctgt
     5221 tcgatgtact ggtgattatg cagaaccagt cgtcggttgc aggtaatggt aatacaggcg
     5281 gtatgtcagg attacaatgg cggcagccgg aaggcatgca aagagtgacg agccagtttg
     5341 atctcgaatt ttcttttatg gagacgggcg actcggtgga ggtgttgctg aactataata
     5401 cagacattta cagcgcctcc tttgtccgca acctgctgac gcacctggaa ctgctgctgg
     5461 catttgccgc cggacatccg gagcacgcac tgggcgtgct ggactattta acatcagcag
     5521 aaaaaatgca gcaactgtct gcgtttaaca atacgaccaa tgattttccg cagacagaaa
     5581 gcattgtcag tctgttccgc cggcaggcac tgctgcggcc ggaagagacg gccgttgttt
     5641 ttgaagacag cgcgttgact taccgggagc tggatgaacg gtccgaccag gtggcgcggc
     5701 tgctgacgga acaactgcag gtacaaccag gagcgttggt agtgctgctg acggaacgct
     5761 ctgttcacct gatggcgggg atgttaggca tcctcaaagc cggagcggct tatgtgccgc
     5821 tggacccggc ctatcctgcg gagcgtatca gctacgtgct ggaggactgc ggcgcccgcg
     5881 tgctggtggc cggcgaagga acagcgctgc cggcaggcta tgacggcgcc gtactacaac
     5941 tggagacagc agtgaacgat gataacgatg ccggttacac gccacacgcc gttttgccgg
     6001 aagacctgtg ttacgtgatc tatacctccg gttctaccgg ccgtccgaaa ggggtgatgg
     6061 taaaccaccg caatgtggtc aacttctttt cggcgatgga ccgggaagtg cctttgcagg
     6121 aggatgactg cctgctggcg atgaccagca cctccttcga tatctccgtg ctggagctgt
     6181 tgtggaccct ctgccgcggg gtacaggtgg tgatacatcc gtcggaccgt atcccgggca
     6241 accttgaccg ttatacggag aaagcaccgg ccacggtgga cttcagcctg tttttcttct
     6301 ccagctacga tcatggcagc gccaataaat acgatcttct gcagtcttcc gtgcgttatg
     6361 ccgacgagca tgggttccgg gcggtatgga cgccggagcg tcattttcat gagtttgggg
     6421 gactgtatcc caacccgtct gttatcgggg cggcgttggc ggtaagcacc cgccggctgg
     6481 agatccgcag tggcagcgtg gtagctccgc tgcacgatac ggtgcgcatc gcggaggaat
     6541 gggccgtggt ggacaacctg tccggcggcc gggtagggct gtcgtttgcc cccggctgga
     6601 acgcgaacga ttttgttttg tcgtctgccc cttatgcatc gcgccatcaa cggatgtacg
     6661 agcagatagc ggaagtgcgc cacctctggg aaggaggcag catcacccgt accaatggct
     6721 tcggacagga agtatcgctg caggtatatc cccgcccggt gcagg
//
