LOCUS       NZ_FUWZ01000018         9650 bp    DNA     linear   CON 22-OCT-2024
DEFINITION  Chitinophaga eiseniae strain DSM 22224, whole genome shotgun
            sequence.
ACCESSION   NZ_FUWZ01000018
VERSION     NZ_FUWZ01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Chitinophaga eiseniae
  ORGANISM  Chitinophaga eiseniae
            Bacteria; Bacteroidota; Chitinophagia; Chitinophagales;
            Chitinophagaceae; Chitinophaga.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-FEB-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900167135.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 16:06:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,843
            CDSs (total)                      :: 6,771
            Genes (coding)                    :: 6,741
            CDSs (with protein)               :: 6,741
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1, 1 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 30
            CDSs (without protein)            :: 30
            Pseudo Genes (ambiguous residues) :: 0 of 30
            Pseudo Genes (frameshifted)       :: 2 of 30
            Pseudo Genes (incomplete)         :: 28 of 30
            Pseudo Genes (internal stop)      :: 1 of 30
            Pseudo Genes (multiple problems)  :: 1 of 30
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:38:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 9650
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FUWZ01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     gene            <1..5559
                     /locus_tag="B5D63_RS34395"
                     /old_locus_tag="SAMN04488128_1181"
     CDS             <1..5559
                     /NRPS_PKS="Domain: PP-binding (208-275). E-value: 1e-17.
                     Score: 56.2. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34395_PP-binding.1"
                     /NRPS_PKS="Domain: Condensation_DCL (316-612). E-value:
                     1.1e-53. Score: 174.3. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34395_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (783-1189). E-value:
                     6.5e-104. Score: 339.7. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34395_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1297-1365). E-value: 1.7e-14.
                     Score: 45.8. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34395_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1381-1682). E-value:
                     2.1e-99. Score: 324.2. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34395_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="B5D63_RS34395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1181"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_143313374.1"
                     /sec_met_domain="PP-binding (E-value: 7.9e-17, bitscore:
                     49.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4e-118, bitscore:
                     382.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.5e-76, bitscore:
                     245.0, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="SADIAANISNIGVPIPTLRTYVLDSRRELVPAGVWGELYVGGAGV
                     SRGYLNREELTGERFMDSWLRAGERLYRSGDRVRWLPHGEMEYGGRFDEQVKIRGYRIE
                     LGEIASTLESHGEVSRALVIARPGTGGLQELVAYVICPETLSPEDLRSWLGRRLPDYML
                     PAGFVRLEALPLTANGKIDRKKLPSYDSSAISSGVAYMAPSNAWEEKLVALFAAELNRA
                     PERTSVKDNFFALGGDSIKGMKLVVKIKKAFNTGITIANLYQHQTVDTLAAWLQQNQLA
                     DTLEQEWHAGMEEIAALRQQIEYEHGGTGILPAAYEDMYPVTPIEQGMIYSSMLRPEEP
                     VYYDQFTSFVQITDIDAFKACLEKLVERHAALRTRYYMQTFRQPIKIVLPEITIPVSYE
                     DLSALHDEEKIVRLRTFLQKDIAIRLAFDNDLLWRLKMLYLGEGKYYLVLNCHHAMIDG
                     WGVSIFSSELANLLGDNPPELRPLKHSYKDYCAIILGRKKSEATANYWRSLLLGYSRNK
                     LPFNYKGLKITEAAGMKKISRVLDNTLLQQLNRLSEDNRLSFKAICLAAHIYLLHIVSS
                     EKDVVTGVVTHERPELEDSTGILGCFLNTVPVRVDFEKVKDTRTLLRTVQDFLVASKPH
                     EVHLSEVAGFISEKASGENPVFDTLFNFTDFHNYRNVNNTSLLAPVAAPFGAVTGEAGE
                     MTNTLFDVELDKTMDRFLLKIKYTPAYFHEEEVHYALSLYERILVSFVADISAPLVPEQ
                     LLPEAERNALLFGFNATLAPYASEKTIHRLFEEQVLKTPDQVALSQHGHDLTYEALNKR
                     ANQVAACLLETGVKPGDNVGLLVTRTFDMIVGMYGILKAGGAYVPVDPEYPADRQEYII
                     NNSGLNTLLVNTPPPEALAGKLQHVTFISLRDSKIDTQPAEDPAIVVDSRQLAYTIYTS
                     GSTGRPKGVMIEHHSAVNLIEWVNDTFEINHNDRLLFITSMCFDLSVYDVFGILAAGGT
                     VVIATQEEVQDVRKLQQLMVDERISFWDSVPTTMNYLVGELELDGGLYRQNNLRLVFLS
                     GDWIPVQLPGTIRKYFPNAQVISLGGATEGTVWSNYYPIGKVPATWSSIPYGVPLKNNF
                     FYILDDNFQPVPRGVAGELYIGGIGVARGYANDPEKTNAAFKPDPFNSSLGGRMYKTGD
                     LGRLMADGNMEFLGRKDNQVKIRGFRVELGEIESVLLKHSGIKEAIVNVIKDAANNNQL
                     CAYLVPKTVVDRKEVRDYLKAVFPAYMVPDHYLVLEALPLNSNGKIDRKALPSPVADES
                     NDLAAYEPPQSALEKSIETIWKSLLKADKVSLTADFFDLGANSLSVGAFVNRVSRDMGL
                     SLNIREVFMHPTIKGIAGLLAARNTGRVQHIQPAVEQPAYVLSSAQQRMWVLSQLDEHG
                     AAYNIPGAFVLEGELDRIALDQAFAAVLERHEILRTVFREEEDGQVMQYVLPAELLANR
                     ITYGDLRNAADQEILLQQQVRTVSHTTFNMGSEPLVRACLYRLSDSKWVFAYVMHHIIS
                     DGWSVNLLMEELLRLYNAFHNNSSPALSPLRIQYKDYAVWQQSQLNSGLLYEHGVYWKS
                     QLGGKLPVLRLPVDKPRPGVKTYNGAYLKRIVSKEVADRLRDYARNEGGTLFMGLLTVV
                     NALMAAYTDQEDIILGTSVAGRENPELENQIGLYVNAVALRTRFAHTITFHELFRRVKQ
                     TTLQAYEHQLYPFDELVQVLDLERDLSRNLLFDVIVVLQNTNIEGSSSIPSMDGMTVTR
                     YKSQARQSSQFDLSFDFFDTGAELVAGIEYNTDLFHSNTAQHIAEHLDHLLAAFTSDPA
                     KRIDELGYRLPAQSPGAPPSGQLLQQSRKGIVNDLKL"
     source          1..9650
                     /db_xref="taxon:634771"
                     /mol_type="genomic DNA"
                     /note="contig: Ga0070509_118"
                     /organism="Chitinophaga eiseniae"
                     /strain="DSM 22224"
                     /type_material="type strain of Chitinophaga eiseniae"
     region          1..9650
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..9650
                     /SMILES="NC(CS)C(=O)NC(CCCNC(N)=N)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..9650
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<0:>9650](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <1..>9650
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS_motif       94..183
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0001"
                     /evalue="1.00E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="60"
                     /protein_start="30"
                     /score="49.8"
                     /tool="antismash"
                     /translation="PAGVWGELYVGGAGVSRGYLNREELTGERF"
     CDS_motif       268..327
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0002"
                     /evalue="4.60E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="108"
                     /protein_start="88"
                     /score="31.6"
                     /tool="antismash"
                     /translation="GGRFDEQVKIRGYRIELGEI"
     CDS_motif       538..564
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0003"
                     /evalue="4.50E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="187"
                     /protein_start="178"
                     /score="4.0"
                     /tool="antismash"
                     /translation="GKIDRKKLP"
     aSDomain        628..828
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34395_PP-binding.1"
                     /evalue="1.00E-17"
                     /label="B5D63_RS34395_PP-binding.1"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="275"
                     /protein_start="208"
                     /score="56.2"
                     /tool="antismash"
                     /translation="EKLVALFAAELNRAPERTSVKDNFFALGGDSIKGMKLVVKIKKAF
                     NTGITIANLYQHQTVDTLAAWL"
     aSDomain        952..1839
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34395_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.10E-53"
                     /label="B5D63_RS34395_Condensation_DCL.1"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="612"
                     /protein_start="316"
                     /score="174.3"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHAMIDG"
                     /tool="antismash"
                     /translation="EDMYPVTPIEQGMIYSSMLRPEEPVYYDQFTSFVQITDIDAFKAC
                     LEKLVERHAALRTRYYMQTFRQPIKIVLPEITIPVSYEDLSALHDEEKIVRLRTFLQKD
                     IAIRLAFDNDLLWRLKMLYLGEGKYYLVLNCHHAMIDGWGVSIFSSELANLLGDNPPEL
                     RPLKHSYKDYCAIILGRKKSEATANYWRSLLLGYSRNKLPFNYKGLKITEAAGMKKISR
                     VLDNTLLQQLNRLSEDNRLSFKAICLAAHIYLLHIVSSEKDVVTGVVTHERPELEDSTG
                     ILGCFLNTVPVRVDF"
     aSModule        952..4098
                     /complete
                     /domains="nrpspksdomains_B5D63_RS34395_Condensation_DCL.1"
                     /domains="nrpspksdomains_B5D63_RS34395_AMP-binding.1"
                     /domains="nrpspksdomains_B5D63_RS34395_PCP.1"
                     /locus_tags="B5D63_RS34395"
                     /monomer_pairings="Cys -> Cys"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1063..1131
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0004"
                     /evalue="4.80E-09"
                     /label="C2_DCL_024-062"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="376"
                     /protein_start="353"
                     /score="28.5"
                     /tool="antismash"
                     /translation="DIDAFKACLEKLVERHAALRTRY"
     CDS_motif       1354..1413
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0005"
                     /evalue="8.10E-06"
                     /label="C3_DCL_135-156"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="470"
                     /protein_start="450"
                     /score="18.5"
                     /tool="antismash"
                     /translation="CHHAMIDGWGVSIFSSELAN"
     CDS_motif       1738..1830
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0006"
                     /evalue="5.10E-07"
                     /label="C5_DCL_263-294"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="609"
                     /protein_start="578"
                     /score="22.2"
                     /tool="antismash"
                     /translation="DVVTGVVTHERPELEDSTGILGCFLNTVPVR"
     aSDomain        2353..3570
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34395_AMP-binding.1"
                     /evalue="6.50E-104"
                     /label="B5D63_RS34395_AMP-binding.1"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1189"
                     /protein_start="783"
                     /score="339.7"
                     /specificity="substrate consensus: Cys"
                     /tool="antismash"
                     /translation="FEEQVLKTPDQVALSQHGHDLTYEALNKRANQVAACLLETGVKPG
                     DNVGLLVTRTFDMIVGMYGILKAGGAYVPVDPEYPADRQEYIINNSGLNTLLVNTPPPE
                     ALAGKLQHVTFISLRDSKIDTQPAEDPAIVVDSRQLAYTIYTSGSTGRPKGVMIEHHSA
                     VNLIEWVNDTFEINHNDRLLFITSMCFDLSVYDVFGILAAGGTVVIATQEEVQDVRKLQ
                     QLMVDERISFWDSVPTTMNYLVGELELDGGLYRQNNLRLVFLSGDWIPVQLPGTIRKYF
                     PNAQVISLGGATEGTVWSNYYPIGKVPATWSSIPYGVPLKNNFFYILDDNFQPVPRGVA
                     GELYIGGIGVARGYANDPEKTNAAFKPDPFNSSLGGRMYKTGDLGRLMADGNMEFLGRK
                     DNQVKIR"
     CDS_motif       2542..2580
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0007"
                     /evalue="4.50E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="859"
                     /protein_start="846"
                     /score="16.7"
                     /tool="antismash"
                     /translation="GILKAGGAYVPVD"
     CDS_motif       2773..2832
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0008"
                     /evalue="1.80E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="943"
                     /protein_start="923"
                     /score="32.6"
                     /tool="antismash"
                     /translation="AYTIYTSGSTGRPKGVMIEH"
     CDS_motif       2944..2976
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0009"
                     /evalue="1.70E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="991"
                     /protein_start="980"
                     /score="-0.0"
                     /tool="antismash"
                     /translation="FGILAAGGTVV"
     CDS_motif       3358..3447
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0010"
                     /evalue="3.10E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1148"
                     /protein_start="1118"
                     /score="48.3"
                     /tool="antismash"
                     /translation="PRGVAGELYIGGIGVARGYANDPEKTNAAF"
     CDS_motif       3535..3600
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0011"
                     /evalue="1.10E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1199"
                     /protein_start="1177"
                     /score="39.8"
                     /tool="antismash"
                     /translation="FLGRKDNQVKIRGFRVELGEIE"
     CDS_motif       3808..3834
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0012"
                     /evalue="1.00E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1277"
                     /protein_start="1268"
                     /score="5.7"
                     /tool="antismash"
                     /translation="GKIDRKALP"
     aSDomain        3895..4098
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34395_PCP.1"
                     /evalue="1.70E-14"
                     /label="B5D63_RS34395_PCP.1"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1365"
                     /protein_start="1297"
                     /score="45.8"
                     /tool="antismash"
                     /translation="EKSIETIWKSLLKADKVSLTADFFDLGANSLSVGAFVNRVSRDMG
                     LSLNIREVFMHPTIKGIAGLLAA"
     aSDomain        4147..5049
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34395_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.10E-99"
                     /label="B5D63_RS34395_Condensation_LCL.1"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1682"
                     /protein_start="1381"
                     /score="324.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIISDG"
                     /tool="antismash"
                     /translation="AYVLSSAQQRMWVLSQLDEHGAAYNIPGAFVLEGELDRIALDQAF
                     AAVLERHEILRTVFREEEDGQVMQYVLPAELLANRITYGDLRNAADQEILLQQQVRTVS
                     HTTFNMGSEPLVRACLYRLSDSKWVFAYVMHHIISDGWSVNLLMEELLRLYNAFHNNSS
                     PALSPLRIQYKDYAVWQQSQLNSGLLYEHGVYWKSQLGGKLPVLRLPVDKPRPGVKTYN
                     GAYLKRIVSKEVADRLRDYARNEGGTLFMGLLTVVNALMAAYTDQEDIILGTSVAGREN
                     PELENQIGLYVNAVALRTRF"
     CDS_motif       4210..4326
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0013"
                     /evalue="5.00E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1441"
                     /protein_start="1402"
                     /score="54.3"
                     /tool="antismash"
                     /translation="AAYNIPGAFVLEGELDRIALDQAFAAVLERHEILRTVFR"
     CDS_motif       4546..4611
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0014"
                     /evalue="3.20E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1536"
                     /protein_start="1514"
                     /score="35.6"
                     /tool="antismash"
                     /translation="MHHIISDGWSVNLLMEELLRLY"
     CDS_motif       4660..4698
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0015"
                     /evalue="1.10E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1565"
                     /protein_start="1552"
                     /score="14.8"
                     /tool="antismash"
                     /translation="QYKDYAVWQQSQL"
     CDS_motif       4951..5040
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0016"
                     /evalue="9.00E-11"
                     /label="C5_LCL_267-296"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1679"
                     /protein_start="1649"
                     /score="34.2"
                     /tool="antismash"
                     /translation="DIILGTSVAGRENPELENQIGLYVNAVALR"
     CDS_motif       5089..5205
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34395_0017"
                     /evalue="8.80E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="B5D63_RS34395"
                     /protein_end="1734"
                     /protein_start="1695"
                     /score="50.2"
                     /tool="antismash"
                     /translation="KQTTLQAYEHQLYPFDELVQVLDLERDLSRNLLFDVIVV"
     gene            5589..6554
                     /locus_tag="B5D63_RS34400"
                     /old_locus_tag="SAMN04488128_1182"
     CDS             5589..6554
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014698.5"
                     /locus_tag="B5D63_RS34400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1182"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_078673429.1"
                     /sec_met_domain="TauD (E-value: 1.2e-10, bitscore: 29.3,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLFQLDEQDNSRINSLLAHLTVQYESPCNPLFLQEARVLSSRLP
                     EPLMSRLNAFRYHEDHNGLLMLRGFEVDDRQIGPTPNATGKEIDEQSAAREGFLLMLLA
                     SFLGDSLGWANQRNGALLNNVLPLKDHESEQLSTGSVADLSWHNEEAFHPFRADYLALM
                     CLRNPDNIPTLVGSIQDVHIPVEIKEILFEPRFIFHTDKNFDQGETYVPVPEPVLFGDF
                     KAPYVRLDPAFMSPAPGDEAADRALTYIIDAFDSALRKVPLTSGDILFMDNYRVVHGRK
                     GFKPRFDGNDRWLKRVNITLDLRKSRAVRPGQRSHVIITD"
     gene            6577..>9650
                     /locus_tag="B5D63_RS34405"
                     /old_locus_tag="SAMN04488128_1183"
     CDS             6577..>9650
                     /NRPS_PKS="Domain: AMP-binding (247-635). E-value: 5e-89.
                     Score: 290.6. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34405_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (743-812). E-value: 3.6e-25. Score:
                     79.9. Matches aSDomain: nrpspksdomains_B5D63_RS34405_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (826-1023). E-value:
                     2.5e-57. Score: 186.1. Matches aSDomain:
                     nrpspksdomains_B5D63_RS34405_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="B5D63_RS34405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1183"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_159456279.1"
                     /sec_met_domain="AMP-binding (E-value: 5e-99, bitscore:
                     319.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.1e-15, bitscore:
                     45.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 2.8e-47, bitscore:
                     148.8, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENYWLKRLEHIQVPDWPYTSPDTVTVTFTVPVPPAVMQAMQAVA
                     GNSSVNMLKLLLGGLGVVLWKYTGLQHAAIALPPLALPGENADDNSTLYCVLHLYATLQ
                     VPALLEQVHEALNDAHLHAGYNETTFRDAFRAANNDRLLAGNVALSYDGLTAPDNWLHE
                     HQLHFEFNAAASHIKVNARNLPLPEKMLRNMAESLLFVAASFSANKEKSIAQCATEPPQ
                     SLHAWMARFNDHRRQYATGLTVVDLFLQQALEHPENTALVFGDTVYSYGGLDEWSARIA
                     AYILQHTSRSQPLFIGVMMHRSAALVAAVLGILRAGAAYVPIDPAYPADRKKSIVADTQ
                     CPLIITDDDASATGIEICSIVNIATVTAVTAARPLPQVVPADVAYVIFSSGTTGKPKGI
                     MIQHQAILNLLYWYNERYDLAAGAKIAQLTNIAVDIAFQEIFSSLMNGLPLYIPRQEEQ
                     QDRHVFVEWLKHHEISFIQLIPDMLATYLQDIPRITTLKQILCGGDKLSESLKDEIVSK
                     GYTLYNIYGQTETAIDTVGAICRYGEPMCFNDYVPNYDVYILDEHGHLCPEYVAGEICT
                     GGQGLALGYLHNPVLTAERFIAHPFEPGRRLYRTGDRARRMPDGSILLLGREDEQVKIR
                     GYRIELGEIEGLLQRFPGIDNAAVIVKEDSTGEKQLAAFLAGSGQLDIQACRAYVKEHL
                     PSYMLPDHFLQLDKLPLTDTGKIDRKRLAAYEGMKPSPSTGYVAPRNETEAQLADMWQQ
                     VIGKEKVGVTDDFFDLGGHSLKVTRLGSLIRKTFGVAVSLKDLFVHSVLEAQAALIAES
                     RKEQQQAIPVLPLQDSYELSSSQHRLWVLSQLEGSNIAYNMPGVLVFEGVLDKEALFSA
                     FTMLVARHEILRTVFRADPAGTVKQYVLDATLLNFRVKEQDLRGAEQQEELLQSCLAGD
                     FYTEFDLAAGPLLRAGLYRLTDSKWVFSYVMHHIISDDWSMGVFFNDLLRLYNGFTGGG
                     EALPPLRIQYKDYASWQRSRLTGTGTGKAYWQEVF"
     aSDomain        7318..8481
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34405_AMP-binding.1"
                     /evalue="5.00E-89"
                     /label="B5D63_RS34405_AMP-binding.1"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="635"
                     /protein_start="247"
                     /score="290.6"
                     /specificity="substrate consensus: Arg"
                     /tool="antismash"
                     /translation="FLQQALEHPENTALVFGDTVYSYGGLDEWSARIAAYILQHTSRSQ
                     PLFIGVMMHRSAALVAAVLGILRAGAAYVPIDPAYPADRKKSIVADTQCPLIITDDDAS
                     ATGIEICSIVNIATVTAVTAARPLPQVVPADVAYVIFSSGTTGKPKGIMIQHQAILNLL
                     YWYNERYDLAAGAKIAQLTNIAVDIAFQEIFSSLMNGLPLYIPRQEEQQDRHVFVEWLK
                     HHEISFIQLIPDMLATYLQDIPRITTLKQILCGGDKLSESLKDEIVSKGYTLYNIYGQT
                     ETAIDTVGAICRYGEPMCFNDYVPNYDVYILDEHGHLCPEYVAGEICTGGQGLALGYLH
                     NPVLTAERFIAHPFEPGRRLYRTGDRARRMPDGSILLLGREDEQVKIR"
     aSModule        7318..9012
                     /complete
                     /domains="nrpspksdomains_B5D63_RS34405_AMP-binding.1"
                     /domains="nrpspksdomains_B5D63_RS34405_PCP.1"
                     /locus_tags="B5D63_RS34405"
                     /monomer_pairings="Arg -> Arg"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       7507..7548
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34405_0001"
                     /evalue="1.10E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="324"
                     /protein_start="310"
                     /score="18.5"
                     /tool="antismash"
                     /translation="LGILRAGAAYVPID"
     CDS_motif       7726..7785
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34405_0002"
                     /evalue="1.40E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="403"
                     /protein_start="383"
                     /score="29.9"
                     /tool="antismash"
                     /translation="AYVIFSSGTTGKPKGIMIQH"
     CDS_motif       8275..8364
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34405_0003"
                     /evalue="1.70E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="596"
                     /protein_start="566"
                     /score="39.5"
                     /tool="antismash"
                     /translation="PEYVAGEICTGGQGLALGYLHNPVLTAERF"
     CDS_motif       8449..8511
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34405_0004"
                     /evalue="1.80E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="645"
                     /protein_start="624"
                     /score="35.9"
                     /tool="antismash"
                     /translation="LGREDEQVKIRGYRIELGEIE"
     CDS_motif       8545..8583
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34405_0005"
                     /evalue="5.20E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="669"
                     /protein_start="656"
                     /score="-2.1"
                     /tool="antismash"
                     /translation="AAVIVKEDSTGEK"
     aSDomain        8806..9012
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34405_PCP.1"
                     /evalue="3.60E-25"
                     /label="B5D63_RS34405_PCP.1"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="812"
                     /protein_start="743"
                     /score="79.9"
                     /tool="antismash"
                     /translation="EAQLADMWQQVIGKEKVGVTDDFFDLGGHSLKVTRLGSLIRKTFG
                     VAVSLKDLFVHSVLEAQAALIAES"
     aSDomain        9055..9645
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B5D63_RS34405_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.50E-57"
                     /label="B5D63_RS34405_Condensation_LCL.1"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="1023"
                     /protein_start="826"
                     /score="186.1"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIISDD"
                     /tool="antismash"
                     /translation="DSYELSSSQHRLWVLSQLEGSNIAYNMPGVLVFEGVLDKEALFSA
                     FTMLVARHEILRTVFRADPAGTVKQYVLDATLLNFRVKEQDLRGAEQQEELLQSCLAGD
                     FYTEFDLAAGPLLRAGLYRLTDSKWVFSYVMHHIISDDWSMGVFFNDLLRLYNGFTGGG
                     EALPPLRIQYKDYASWQRSRLTGTGTGKAYWQEV"
     CDS_motif       9124..9237
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34405_0006"
                     /evalue="4.60E-15"
                     /label="C2_LCL_024-062"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="887"
                     /protein_start="849"
                     /score="48.0"
                     /tool="antismash"
                     /translation="AYNMPGVLVFEGVLDKEALFSAFTMLVARHEILRTVFR"
     CDS_motif       9457..9522
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34405_0007"
                     /evalue="1.90E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="982"
                     /protein_start="960"
                     /score="36.3"
                     /tool="antismash"
                     /translation="MHHIISDDWSMGVFFNDLLRLY"
     CDS_motif       9568..9606
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B5D63_RS34405_0008"
                     /evalue="9.20E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="B5D63_RS34405"
                     /protein_end="1010"
                     /protein_start="997"
                     /score="18.1"
                     /tool="antismash"
                     /translation="QYKDYASWQRSRL"
ORIGIN
        1 tccgccgata ttgcggccaa catcagcaac atcggcgttc ctatccccac attgcggacc
       61 tatgtgctgg atagccggcg ggagctggtg ccggcaggag tatggggtga gctgtatgta
      121 ggcggcgccg gggtctcccg tggttacctg aaccgggaag agctgacagg cgaacgcttt
      181 atggatagct ggctgagagc aggggagcgg ttgtaccggt caggagaccg ggtacgttgg
      241 ttgccgcatg gagagatgga atatggcggc cgttttgatg aacaggtaaa gatccgcggt
      301 taccggatag agttggggga gatagcgtct acgctggaaa gccacgggga agtgagccgg
      361 gcgctggtga tagcgcgtcc cggtaccgga gggctgcagg agctggtggc ttatgtgata
      421 tgtccggaaa cactgtcgcc ggaagatctg cgcagctggt taggccgccg tttgcccgac
      481 tacatgcttc cggcaggttt tgtacgcctg gaagcgctgc cccttaccgc caacggtaag
      541 atagacagga aaaaattgcc ctcgtacgat agcagcgcta tcagtagcgg cgtggcatat
      601 atggcgccgt ccaacgcatg ggaggaaaaa ctggtagcgc tgtttgccgc ggaattgaac
      661 agagcgccgg aaagaacaag tgtgaaggac aacttttttg cgctgggagg cgattctata
      721 aagggcatga agttagttgt gaagatcaag aaagcattta atacaggtat taccattgcc
      781 aatctttatc agcatcaaac cgttgatacc ctggcggcct ggttgcaaca aaaccagttg
      841 gcggacaccc tcgaacagga atggcatgcc ggcatggagg aaatagcagc cttgcgtcag
      901 cagatagaat atgagcatgg cggaacaggt attttgccgg ccgcttatga ggacatgtat
      961 ccggtaacgc ccatcgaaca gggcatgatc tattcttcca tgcttcgtcc tgaagaaccg
     1021 gtctattacg atcagtttac ctcttttgta cagataacag atatcgatgc ctttaaggcg
     1081 tgcctcgaaa aactggtaga acgacatgca gcactgcgta ccaggtatta catgcagacc
     1141 ttccggcagc cgataaaaat agttttgccg gaaataacta ttcctgtttc ctacgaagat
     1201 ttgagcgcct tgcacgatga ggaaaagata gttcgcctgc gtacgttcct gcaaaaagat
     1261 atagccataa gattagcttt tgataatgat ttgctgtggc gtctgaaaat gttatatctg
     1321 ggagaaggaa aatattatct cgttcttaac tgccaccacg ctatgataga tggctgggga
     1381 gtatccatat tttcaagcga gctggccaat ctccttggtg ataacccgcc ggaactgcgc
     1441 ccgttaaaac atagttataa agattattgc gctattatac tgggccggaa aaaatcggaa
     1501 gccacggcca actattggag atcattactg ttgggttatt ccaggaataa gctgcccttt
     1561 aattataaag gcctgaaaat aacagaagcc gcaggcatga agaaaatatc ccgtgtgctt
     1621 gataatacac tgctgcaaca gctaaaccgt ctctccgagg ataaccggtt gtcgtttaaa
     1681 gctatttgtc tcgctgcgca tatttacctg ctgcacattg tctcctccga aaaagatgtt
     1741 gttaccggcg tggtaacaca tgaacgcccc gagctggaag acagcaccgg catactgggc
     1801 tgcttcctga acaccgtgcc tgtaagggtt gactttgaaa aagtaaaaga tacccgtacg
     1861 ctgctgagga ccgtgcagga ttttctggtg gcctccaagc ctcatgaagt acacttaagt
     1921 gaagtggcag gttttatcag tgaaaaagca tcgggcgaaa accctgtctt tgataccctg
     1981 tttaacttta cagactttca taattaccgt aacgtcaaca acacttccct gctggcgccg
     2041 gtagccgctc cattcggggc tgtgaccgga gaggccggtg aaatgaccaa cacgcttttt
     2101 gacgtggagc tggataagac gatggaccgt ttcctgctta aaataaaata tacgccggcc
     2161 tattttcacg aagaggaagt tcactatgcg ttaagtctgt atgaaaggat actggtatca
     2221 ttcgttgcag atatctcagc gccactggtg ccggaacaat tgctgcccga agcagaacgc
     2281 aacgcgttac tgttcggttt caacgcaaca ctagcgcctt acgccagcga aaaaacaatc
     2341 caccggcttt tcgaagagca ggtattgaaa accccggatc aggtggcatt aagccagcat
     2401 ggccacgatc tcacctacga agctcttaat aagcgcgcaa accaggtggc ggcctgtctt
     2461 cttgagacag gcgttaaacc cggtgataat gtcgggctgc tggtcacgcg cacttttgac
     2521 atgatcgttg gaatgtatgg tattttaaaa gccgggggcg catatgtgcc ggtcgatccg
     2581 gagtatcctg ctgaccgcca ggagtatatc attaataatt ccggactaaa caccctgctg
     2641 gtaaataccc cgcccccgga agcattggcc gggaagctac agcatgtcac gtttatatcc
     2701 ctccgggaca gcaagatcga cacacagcct gcagaagatc cggcaatcgt tgtcgatagc
     2761 cgccagctgg catacactat ctatacttca gggtcaaccg gacgtcccaa aggagtgatg
     2821 attgagcatc attcggcagt gaacctgata gaatgggtga atgatacctt tgagataaat
     2881 cataacgatc gcctgctgtt cattacctct atgtgttttg acctttccgt atatgacgtc
     2941 ttcggcatac tggccgccgg aggcacggtg gtaatcgcta cgcaggagga ggtgcaggat
     3001 gtaaggaagc tgcagcagct gatggtagac gaacgcattt ctttctggga ttccgtgcct
     3061 actacgatga attacctggt cggggagctg gagctggatg gtggtctgta caggcaaaac
     3121 aacctgcgcc tggttttcct gagcggcgac tggatacctg tgcagctgcc ggggaccata
     3181 cggaaatatt ttccgaatgc acaggtcatc agcctgggcg gtgctaccga aggtaccgtt
     3241 tggtctaact attatccaat aggaaaagta ccagcaacct ggagcagtat tccctatgga
     3301 gtgcccctta agaacaactt cttctacatt ctggacgata acttccagcc agtaccaagg
     3361 ggtgtggccg gggaactgta tatcggaggc atcggcgtgg ccaggggata tgccaacgac
     3421 ccggagaaga ccaacgccgc tttcaagccc gatcctttta acagtagcct gggggggcgc
     3481 atgtataaaa ccggcgacct gggacggctt atggcggatg ggaatatgga attcctcgga
     3541 cgaaaggata accaggtaaa aataagaggc ttccgggttg agctggggga gatagaaagt
     3601 gtgttgttaa agcacagcgg tataaaagag gccattgtga atgttataaa ggacgctgcc
     3661 aacaataacc agctctgtgc ttatctggtg ccgaaaacag ttgtcgaccg caaagaagtg
     3721 cgcgactacc tgaaagcggt tttcccggcc tacatggtac cggaccatta cctggtcctg
     3781 gaggcattgc ccctgaacag taacgggaag atagaccgca aagcactgcc gtcgccggtt
     3841 gcggatgaaa gcaacgatct ggcggcctat gagccaccgc aatccgccct ggaaaagagc
     3901 attgaaacca tatggaaatc actgttgaag gccgataaag taagccttac cgccgatttc
     3961 tttgatctgg gagccaattc tctctctgta ggggctttcg taaacagggt ctcccgcgat
     4021 atggggctgt ccctcaacat ccgtgaggta tttatgcatc ctacgatcaa aggcattgcc
     4081 ggtctgctgg ctgcacggaa taccggccgg gtacagcata tacagccggc tgtagaacag
     4141 ccagcttatg tgctttcctc cgctcagcag agaatgtggg tgctcagcca gttggatgaa
     4201 catggcgcgg cttataacat acccggcgcg tttgtactcg aaggcgagct ggatcgtatc
     4261 gcgcttgatc aggcatttgc tgcggtactg gagcgtcatg agatattacg tactgtattc
     4321 cgggaagagg aagacggcca ggtgatgcaa tatgtgctcc cggctgaact gctcgccaac
     4381 aggattacgt acggcgatct ccgtaatgca gccgatcagg agatactgct gcaacagcag
     4441 gtacggacag tgtcgcatac caccttcaac atgggcagcg agccactggt acgggcatgc
     4501 ctgtatcggt tgtcagatag taaatgggta tttgcctatg tcatgcacca cattatcagc
     4561 gatggctggt ctgtaaatct gctgatggag gaactgctgc gcctgtataa tgcttttcac
     4621 aacaacagca gtccggcatt gtctccattg cgcattcaat ataaagacta tgcggtatgg
     4681 caacaatcgc agttaaacag tggcttgttg tatgagcacg gcgtctactg gaaatcacag
     4741 cttggcggta aactgccagt gctccgtctg ccggtcgata agccccgccc cggcgttaaa
     4801 acatataacg gcgcttacct gaaacgcatc gtcagcaaag aagttgcgga caggctgaga
     4861 gattatgccc ggaacgaagg cggtacactg tttatgggat tgcttactgt tgtcaatgct
     4921 ttgatggcgg catataccga tcaggaggat attatccttg gaacttccgt ggccggaaga
     4981 gaaaatccgg agctggaaaa ccagattggg ttgtatgtaa atgctgtggc gctgcgtacc
     5041 cgctttgcac acactattac ctttcacgag ttgttccgcc gcgtaaaaca aactaccctg
     5101 caggcttatg agcatcagct gtatcccttt gatgaactgg tacaggtgct ggatctggag
     5161 cgggaccttt cccgtaacct gttgttcgat gtgatagtgg tattgcagaa cacaaacatc
     5221 gaaggcagca gctccatccc gtcgatggat ggtatgaccg tcacccgcta taaaagccag
     5281 gcacggcaat caagccagtt tgatctttca tttgatttct ttgataccgg tgcggagctg
     5341 gttgcaggca tagagtacaa caccgatctg tttcacagca ataccgctca acatatagcg
     5401 gagcacctgg accacctgct ggcggcattt acatcggatc ccgctaaaag gatagatgaa
     5461 ttgggataca ggttgccggc gcagtcacct ggcgcgccgc cttccggcca gcttctccag
     5521 cagtcaagga aaggaattgt taacgatttg aaattatagg tcctttgcca cttcataaat
     5581 tgtatgttat gaacctcttt caattagatg agcaggataa tagccggatc aacagcctgc
     5641 tggcacatct taccgtgcaa tatgaatctc cctgtaaccc cctgttcctg caggaggctc
     5701 gtgtattgtc ctcgcgtttg cctgagcccc tgatgagccg cctgaatgct ttcagatacc
     5761 acgaagatca caacgggttg ctgatgcttc gcgggtttga ggtcgatgat cgccagatag
     5821 gccctacccc caatgccacg ggtaaagaaa tagatgagca atccgctgcc cgtgagggat
     5881 ttcttttaat gctcctggct tccttcctgg gcgattcact gggctgggct aatcagcgta
     5941 acggggccct gctgaataat gtgctcccgt tgaaggacca cgagtcagag cagctgagca
     6001 ccggaagtgt ggctgatctg agctggcata acgaagaggc tttccacccc ttcagggcag
     6061 attatcttgc tttgatgtgc cttcgtaacc ccgataatat tccgacgctg gtaggttcta
     6121 tacaggatgt ccacatccct gtcgaaataa aagagatcct gtttgaacca cgatttatat
     6181 ttcatacaga caagaatttt gatcagggag aaacttatgt gcctgtgcca gaacccgtgt
     6241 tgtttgggga ctttaaggct ccttacgtgc ggctggaccc tgcctttatg agcccggcac
     6301 caggtgatga ggccgctgac agggccctta catatatcat agacgctttt gacagcgcat
     6361 tgcgtaaagt gccgctgacc tccggcgaca tattatttat ggataactac agggtagtgc
     6421 atggccgtaa agggtttaaa cctcgttttg atgggaatga ccgttggctg aagcgcgtga
     6481 acatcacgct ggatcttcgc aaatcccgcg ccgttaggcc tgggcagcgt tcccatgtta
     6541 ttattacaga ttaagtatct acaggaaaat atttgtatgg aaaattattg gttgaaaaga
     6601 ttggagcaca tacaggtccc cgattggccg tatacctcgc ccgacaccgt aacagtaacg
     6661 tttacggtgc ctgtgccacc tgctgttatg caggcaatgc aggccgtggc aggaaacagc
     6721 agcgtgaata tgctgaaatt gcttctgggt ggactgggcg tggtattatg gaagtacacc
     6781 ggcttgcagc atgctgctat cgcattgccg ccgttggcgc ttcctggcga gaatgctgat
     6841 gataacagca ctttgtattg cgtactgcac ctgtacgcaa cgttgcaggt accagcgctg
     6901 ctggaacagg tgcatgaagc gctgaatgat gcgcacctgc atgcggggta taatgaaacc
     6961 acattcaggg atgccttcag ggcagctaac aatgatcggc tgttggctgg caacgtagcc
     7021 cttagctatg atggccttac agctccggac aactggctgc atgagcatca gctgcatttt
     7081 gaattcaatg ccgctgcatc gcatataaag gtcaacgccc ggaatttgcc gctgccggaa
     7141 aagatgctgc ggaacatggc ggaaagcctg ttgtttgtag ccgcttcttt ttctgccaat
     7201 aaagagaaaa gtattgcaca atgtgcaaca gagccaccgc agagcttaca tgcatggatg
     7261 gcgaggttta atgatcaccg caggcaatat gcaaccggcc ttacagtggt ggacctgttc
     7321 ctgcaacagg ccctggagca tccggaaaat acagcgttgg tattcggaga taccgtttac
     7381 agttatggcg gattggatga atggtccgca cggattgccg cctatatcct gcagcataca
     7441 tcacgctcgc agccgctgtt tatcggggtg atgatgcatc gttcagccgc gctggtagca
     7501 gctgttctgg gcatcttgcg cgctggcgcc gcttatgtgc ccatagatcc tgcttatcct
     7561 gcagatcgta aaaagagtat tgtagcagac actcaatgcc cccttatcat aacggatgat
     7621 gatgcatctg caacaggaat agaaatttgc agtattgtaa atatcgcaac tgtcactgcg
     7681 gtgactgccg cccggccatt accgcaggta gtaccggcag atgtggccta tgtgatcttc
     7741 tcttccggca ctaccggaaa gccgaaaggt atcatgatac agcatcaggc tatcctgaat
     7801 ttactgtact ggtataacga gcgctatgat cttgccgcag gcgcaaaaat cgcgcagctg
     7861 actaacatcg cggtggatat cgctttccag gaaatcttct cttcgctgat gaacgggctt
     7921 ccgctgtata taccacggca ggaagagcag caggacaggc acgttttcgt tgaatggctg
     7981 aaacatcacg aaatcagctt cattcagctt atacctgaca tgctggccac ctatttgcag
     8041 gatataccac gtataactac ccttaagcag atactgtgcg ggggggacaa attaagcgaa
     8101 agcctgaagg atgagatagt gagcaaagga tatacgctct ataacatcta cgggcaaacg
     8161 gaaaccgcca ttgacacagt aggagcgata tgccgttatg gagaacccat gtgttttaat
     8221 gattatgtac ctaattacga tgtgtatata ctggacgagc atgggcacct gtgccccgaa
     8281 tatgtggcag gagagatctg cacgggtggt cagggcctgg ccctgggcta tctccataat
     8341 ccggtattaa cggccgaaag gtttattgca catccttttg aacctggccg ccgtctgtac
     8401 aggaccggtg acagggcccg gcgtatgccg gatgggagca tcctgctgct gggccgcgaa
     8461 gatgaacagg taaagatacg cggttatcgc attgagttag gggagataga aggcctgttg
     8521 caacgcttcc ccggaattga taatgcggcg gtgatagtaa aggaagattc caccggtgaa
     8581 aagcagctgg cggcgttcct ggcggggagc gggcagctcg atatacaggc ctgccgcgct
     8641 tatgtgaaag agcacctgcc gtcgtatatg ctgcctgatc atttcctgca gctggataaa
     8701 ctgcccctca ctgacaccgg gaaaatagac cgcaaacgac tggctgcata cgaaggaatg
     8761 aaaccatcgc cctcaacagg gtatgtcgcg cctcgtaatg aaacggaagc tcagctggct
     8821 gacatgtggc aacaggtgat cggtaaggaa aaggtgggcg tgacggatga tttttttgat
     8881 ctgggtgggc atagcctgaa agtaacacgc ctgggaagcc tgatccgcaa aacatttggc
     8941 gtggccgtta gcttaaaaga tctttttgtg cattccgtgc tcgaggcaca ggcagcgctg
     9001 atcgctgaaa gcaggaagga gcagcagcag gcgataccgg tgttgcccct gcaggatagt
     9061 tatgagctat cctcgtcaca gcaccgcctg tgggtattat cccagttgga aggcagcaac
     9121 attgcctaca atatgccggg cgtgctggta tttgaaggtg tgctggataa ggaagcgctc
     9181 ttttcagctt ttacaatgct tgttgccagg catgagatct tacgcaccgt attcagggcc
     9241 gatccggcag gtactgtaaa gcaatatgtg ctcgacgcca ccctgctgaa cttcagggtg
     9301 aaggagcagg acctgcgtgg cgcagagcag caggaggagc ttttgcaatc ctgcctcgca
     9361 ggtgattttt atacggaatt cgacctggca gccggccccc tgttgcgtgc gggcctctac
     9421 aggcttacgg atagtaaatg ggtgttcagc tatgtgatgc accatattat cagcgacgac
     9481 tggtccatgg gcgtattctt caacgatctg ctcagactct acaacggatt taccggcggc
     9541 ggcgaagcat tgcctcccct gcgcatacaa tacaaggatt atgcttcctg gcagcgtagc
     9601 cgtttaaccg gcacgggaac gggcaaagcc tactggcagg aagtgttcag
//
