LOCUS       NZ_FUWZ01000002        10927 bp    DNA     linear   CON 22-OCT-2024
DEFINITION  Chitinophaga eiseniae strain DSM 22224, whole genome shotgun
            sequence.
ACCESSION   NZ_FUWZ01000002
VERSION     NZ_FUWZ01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Chitinophaga eiseniae
  ORGANISM  Chitinophaga eiseniae
            Bacteria; Bacteroidota; Chitinophagia; Chitinophagales;
            Chitinophagaceae; Chitinophaga.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-FEB-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900167135.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 16:06:51
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,843
            CDSs (total)                      :: 6,771
            Genes (coding)                    :: 6,741
            CDSs (with protein)               :: 6,741
            Genes (RNA)                       :: 72
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1, 1 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 30
            CDSs (without protein)            :: 30
            Pseudo Genes (ambiguous residues) :: 0 of 30
            Pseudo Genes (frameshifted)       :: 2 of 30
            Pseudo Genes (incomplete)         :: 28 of 30
            Pseudo Genes (internal stop)      :: 1 of 30
            Pseudo Genes (multiple problems)  :: 1 of 30
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:38:25
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1653248
            Orig. end                         :: 1664175
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FUWZ01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10927
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10927
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10927
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5927](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5927)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    152..165
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(163..172)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.48"
                     /tool="antismash"
     misc_feature    complement(186..199)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.19"
                     /tool="antismash"
     gene            complement(348..620)
                     /locus_tag="B5D63_RS16450"
                     /old_locus_tag="SAMN04488128_1021397"
     CDS             complement(348..620)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B5D63_RS16450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN04488128_1021397"
                     /product="hypothetical protein"
                     /protein_id="WP_078669866.1"
                     /transl_table=11
                     /translation="MSKESPNLLFSIHEKFSGMAALFRERVCQDCNWSTPTFYRKMRAK
                     EGRGNAETSRQSAFLSSAEKKRIVEIMDEVYNTFWKSAIKYRTPR"
     misc_feature    complement(676..688)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     misc_feature    839..853
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.7"
                     /tool="antismash"
     misc_feature    840..853
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.22"
                     /tool="antismash"
     misc_feature    1042..1058
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 22.99"
                     /tool="antismash"
     misc_feature    1057..1070
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.57"
                     /tool="antismash"
     gene            1078..1689
                     /locus_tag="B5D63_RS16455"
                     /old_locus_tag="SAMN04488128_1021398"
     CDS             1078..1689
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024835.5"
                     /locus_tag="B5D63_RS16455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1021398"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_078669867.1"
                     /transl_table=11
                     /translation="MMQSSLIHMGQRLKQILKQKKIKIIDFAKMAGFTNQIAHYHLRNG
                     DMKRVNLERFCEIIGITPDEFIRWNGTMQLANGKSIHHGNRLQHLIAEKGLNKSKLAER
                     LNMSRRTMYNVFEKETFSPDELDRVARGLDMTPEAFLNPGTTQETRQTDSEEMMVLREK
                     YYKILEEHNQLLKNYTALKDDVLKMKKELATLRKGKAKRG"
     gene            complement(1729..2268)
                     /locus_tag="B5D63_RS16460"
                     /old_locus_tag="SAMN04488128_1021399"
     CDS             complement(1729..2268)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018613848.1"
                     /locus_tag="B5D63_RS16460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1021399"
                     /product="5'(3')-deoxyribonucleotidase"
                     /protein_id="WP_078669868.1"
                     /transl_table=11
                     /translation="MARIAIDMDNVMADIYSHYLNYYETSHGIKLDPQGLHGVPEGEVL
                     PEGLVRKFLLTPGFFRTAPVMPGSQEVIKALMEKYEVFIVSAAMEFPQSLREKLEWLHE
                     HFPFISWHNIVLCGSKTIVNADIMIDDYDKNLRHFKGRQLLFTAPHNVHLTDYERVHNW
                     EEVAAALEVEVPAARV"
     misc_feature    complement(2283..2296)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.07"
                     /tool="antismash"
     gene            2341..3096
                     /locus_tag="B5D63_RS16465"
                     /old_locus_tag="SAMN04488128_1021400"
     CDS             2341..3096
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012788596.1"
                     /locus_tag="B5D63_RS16465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1021400"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_235021554.1"
                     /transl_table=11
                     /translation="MASMLKEERLDYILKKLQTDQKVLQTELSTDLQVSEDTVRRDLEA
                     LAQSGQLIKVRGGAIPHSPNPYSFKERVERHAADKQLMARKALTLLHDGQTVLMDGGTS
                     TLALVKLLPPQLRLTIITNSVPIVTQLIEHPTIEVIFTGGRIGKNSQTATGMDTIRAMQ
                     KIRADLAFVGICSLHPEAGVTGLDLEEADVKSVMIEAANKIVALATSDKMDTAEPFKVC
                     EITGIDVIVTDKPQLPLFKPYQDLGIQVI"
     gene            3132..4286
                     /locus_tag="B5D63_RS16470"
                     /old_locus_tag="SAMN04488128_1021401"
     CDS             3132..4286
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012788597.1"
                     /locus_tag="B5D63_RS16470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1021401"
                     /product="MFS transporter"
                     /protein_id="WP_078669870.1"
                     /transl_table=11
                     /translation="MLQDLSIPVIHKRGTRIAVSALFFLTGLCFASWASRIPDIQQSLH
                     LNDAGLGSVLLALPVGSLISLPVAGVLVSRFGSKQVLIIAAVAYAAILPVLGLAKAPWE
                     LISFLVFFGFCGNLANIAVNTQAVAVEAMYGRSIMASFHGLWSVAGFTGAAIGAAMSGL
                     HLQPVYHFLLITGISWTLVLLTMRHIVQQDNNVQANQPLFVKPDRFLLTLGIIAMCSMI
                     CEGTMFDWSGVYFRRVVKVDEGLGGAGYAAFMGTMASGRFVADWMITRLGTRKMLIISG
                     TLTAAGLLVAVAFPYLVSATLGFMLVGAGVSAVVPLVYSAAGKSSVLSPGMALAAVSTI
                     GYLGFLFGPPLIGFVAQATSLAVSFSLIAVMGAAIAIMSTRLKL"
     misc_feature    complement(3146..3160)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 20.1"
                     /tool="antismash"
     misc_feature    3171..3184
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.65"
                     /tool="antismash"
     gene            complement(4377..4994)
                     /locus_tag="B5D63_RS16475"
                     /old_locus_tag="SAMN04488128_1021402"
     CDS             complement(4377..4994)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B5D63_RS16475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN04488128_1021402"
                     /product="hypothetical protein"
                     /protein_id="WP_078669871.1"
                     /transl_table=11
                     /translation="MSLLSFQQALAALIASPELCVEARQQPDAVFASYDLTDRERKRLE
                     SVVFQRGMSVNCTLYRVNRITPIYTLLPYTCLLLGNRLMPLATAFWEACRQSDLQFKRE
                     IEGFADYLEQQIIQGRLQVLYLPEILRMETAINALKFLPKQQDAALKVRYIPFEHEPGP
                     LLEALSALRLPEVRPAVGNWLLIIDYSGEEMFFSTTSTFEAS"
     gene            complement(5001..5927)
                     /locus_tag="B5D63_RS16480"
                     /old_locus_tag="SAMN04488128_1021403"
     CDS             complement(5001..5927)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016970.5"
                     /locus_tag="B5D63_RS16480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1021403"
                     /product="DUF692 family multinuclear iron-containing
                     protein"
                     /protein_id="WP_078669872.1"
                     /sec_met_domain="DUF692 (E-value: 2.3e-53, bitscore: 177.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYPAKLTGYSSRLYEKTIPRLGVGLLYNPSLELYLDSPATCCDYV
                     EIIPDMFWTDLGNGHPGRFEEIDSWMDVLHKLAARYPLTAHNISYSLGSAGIFDMAYLH
                     KMEEWHQRFSFVWHSDHLSFVKVHDEHQQERNAGMAVPVPYDYEVLDMIDGRINTISRS
                     IRAPFLVENNVYFIDLPEQELSETDFLNELSQDTACGLLLDIHNVYTNAVNHGFDPRSF
                     IAALDLGKVVEIHIAGGNEMAGMYTDSHAGPCPEAVWELLEYTLPLVPNLCGITFEFHE
                     SYFHLLQFDGITRELNRAKAVWNQYHT"
     gene            complement(5978..6229)
                     /locus_tag="B5D63_RS16485"
                     /old_locus_tag="SAMN04488128_1021404"
     CDS             complement(5978..6229)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B5D63_RS16485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN04488128_1021404"
                     /product="hypothetical protein"
                     /protein_id="WP_078669873.1"
                     /transl_table=11
                     /translation="MRTAEVHYGTDGQVNLTVPKGTKMADIARLQELVISKINPRGCQA
                     CLSGVHFNIREELEHVMKVDLDKMATIKGTIKGTVIGH"
     misc_feature    6446..6464
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.49"
                     /tool="antismash"
     misc_feature    complement(6496..6505)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.48"
                     /tool="antismash"
     gene            6615..9431
                     /gene="carB"
                     /locus_tag="B5D63_RS16490"
                     /old_locus_tag="SAMN04488128_1021406"
     CDS             6615..9431
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="carB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008586614.1"
                     /locus_tag="B5D63_RS16490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488128_1021406"
                     /product="carbamoyl-phosphate synthase large subunit"
                     /protein_id="WP_078669874.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 5.1e-08, bitscore:
                     29.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 9.2e-09,
                     bitscore: 31.8, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 2.6e-07, bitscore:
                     27.1, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKDSSIKSVLIIGSGPIIIGQACEFDYSGSQAARSLREEGIKVI
                     LINSNPATIMTDPMMADKVYLLPLTVESIEQILEENQIDAVLPTMGGQTALNLCKEVDE
                     LGIWEKFNVRLIGVDIKAIDKAEDREQFRQWMLRIGIPVAPAKTANSFLEGKEFAQEIG
                     FPLVIRPSFTLGGTGGGFVHSKDELDEALDRGLKASPIHEVLVEKAVLGWKEYELELLR
                     DKNDNVVIICTVENLDPMGIHTGDSITVAPAMTLSDTAFQDMRNKAMMMMRDLGNFAGG
                     CNVQFSLNPENEELIAIEINPRVSRSSALASKATGYPIAKIAAKLAIGYTLDELENQIT
                     KTTSAFFEPALDYVIVKMPRWNFDKFKGADDTLGLQMKSVGEVMAIGRTFPEALQKACQ
                     SLENDALGLGYYGKSLMKSEQLIEKLKRPTWDRIFRIKDALMAGASVKHIHQQTYIDRW
                     FLHQIQDIVNLEKQLGEHDLESVPADMLADAKKLGFSDAQLAVIFGNCEEEEVYEKRKA
                     NGIVRTYKMVDTCAAEFEAKTPYFYSTFDTENESKVTDRKKIIVLGSGPNRIGQGIEFD
                     YCCTHGLQAIQDCGYEAIMVNCNPETVSTDFDMADKLYFEPVFWEHLWEIIELEKPEGV
                     IVQLGGQTALKLAKRLEEKGIKIIGTSFDSMDIAEDRGRFSDMLKDLGIPYPKYGTAYN
                     TDDAIEVAKEVGYPVLVRPSYVLGGQRMRIVINEEELEQSVLSLLRHLPGNKILIDHFL
                     DRCQEAEIDGIFDGTDFHVMGVMEHIEPAGIHSGDSHALLPAFNLTPIEVTTMEYYAEK
                     IARALNIRGLINIQFAVKDGQVYVIEANPRASRTTPFIAKAYQVPYLNIATKVMIGDKK
                     LKDFKIEKKLSGFAIKEPVFSFNKFPGVNKELGPEMKSTGEAIRFIKDLRDPYFRQLYK
                     EKSMYLSK"
     misc_feature    9620..9632
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 21.58"
                     /tool="antismash"
     misc_feature    complement(9694..9707)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     misc_feature    complement(9766..9775)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.48"
                     /tool="antismash"
ORIGIN
        1 ttccgggtct attacactct gctgataagc ctgttgataa tcttctatag tcttgatctg
       61 gtaagggtac gacatagcac catgaatgtt tattggttaa gtagattttt tcctaacggg
      121 ctttaaattt aagaaaaacc cgacggtatg ctagaaaaaa tctaaaaaat catattaaaa
      181 ccagattatt tttcaaaatg ggttggaaga aaggccatgg taaaagcacc tttagggcac
      241 aacaatagcc gttgcccgct ggggcaggct ggtaaaggga tgccgctaaa ggtgctgaag
      301 aaggacaggt tggcaaggca ggcgccagga ggtctgtaat ggtcagttta cctgggggtg
      361 cggtacttga tcgccgattt ccagaaggtg ttgtacactt catccatgat ttccacaatg
      421 cgcttttttt ccgcgctgct cagaaaagcg ctctgcctgg acgtttcggc gttgccgcgt
      481 ccttctttgg cgcgcatttt ccggtaaaat gtgggggtgc tccagttgca gtcctgacat
      541 accctttccc ggaagagggc ggccatgccc gaaaactttt catgaatgga aaacaagagg
      601 ttgggtgact ccttactcat aataacaatc tttttatgat gaacaatgga atcacagtta
      661 tacccgtacg gccggttgca aaatgagatt atttatggct gttagcaaat acagttataa
      721 ctgtgaaaat tatcagcata aaattacact atttgcgata taaaaatcat gtaacccttt
      781 gtggtattga ttttagagtg tttgttggag aggttttccg atcagtttca gcggatattt
      841 atcattatga taacggggcg gttgagatat gatttttagg atcgttttat actgatttca
      901 atcaaaatga tcgtgaaata attttttcag cctacgtata ggcataaaag ttagcacatc
      961 ggatcaatat gctacctgct atgatcaatt tattattttt taacgcgatt tggtaatttt
     1021 atttacgaaa tgaaagatta attgttatat tatacaatta tttataaaaa agcataaatg
     1081 atgcagtcga gtttgataca tatgggccag cgattaaagc agatactgaa gcagaaaaaa
     1141 atcaaaatca tcgattttgc aaaaatggcc ggcttcacca accaaattgc tcactatcac
     1201 ttgaggaacg gggatatgaa gcgggtcaac ctggaacgtt tttgtgaaat tatcggtatc
     1261 acgccggacg agtttatccg ctggaacggc accatgcagc tggccaacgg aaagagtata
     1321 caccacggga accgccttca gcacctgatt gcggagaaag gactcaacaa gagcaaactg
     1381 gccgaacgac tcaatatgag caggcgtacc atgtataatg tttttgaaaa ggaaaccttt
     1441 tcgccggatg aactggaccg ggtagcccgt ggactggaca tgacgccgga agcattcctg
     1501 aatcccggca ccacacagga aacaaggcag acagacagcg aagaaatgat ggtgctgcgg
     1561 gagaaatact ataaaatact ggaagagcac aaccagctgc tgaagaacta cacagccctg
     1621 aaagatgatg tgcttaaaat gaagaaagag ctggccacgc tccgtaaagg aaaagcgaag
     1681 aggggataaa cctcctgtaa ccagccgtta tgttatcccc cattgtggtt atacccgggc
     1741 agccggaact tctacttcca gcgctgctgc tacttcttcc cagttgtgta cccgctcgta
     1801 atctgtcaga tgaacattgt gcggtgccgt aaacaacaac tgccttccct taaaatgccg
     1861 caggttcttg tcgtagtcgt caatcatgat gtcggcgttc acaatggttt tggagccgca
     1921 aagcacaata ttgtgccagc tgatgaaagg gaaatgttca tgcagccatt ccagcttttc
     1981 acggagtgac tgtggaaatt ccatggccgc agatacaatg aagacttcat atttctccat
     2041 cagggctttg atcacttcct ggctgcccgg cattaccggc gctgtcctga aaaagcccgg
     2101 cgtcagtaaa aacttcctga ccagcccctc aggcagtact tccccttcgg gaacaccgtg
     2161 caagccttgc gggtccagct taataccgtg cgacgtttcg taataattga ggtaatggct
     2221 gtaaatatcc gccattacat tgtccatatc tattgctatt cttgccatat tttgcggttt
     2281 attgcaaaga tatgcaaata attgcagaat attgcaaatt attacataat attgcagaaa
     2341 atggcaagta tgctgaaaga ggaaagactt gattatatac taaagaagct gcaaaccgat
     2401 cagaaagtat tacagacgga actgagtacc gacctgcagg tatcggaaga tacggtgcgg
     2461 cgggacctgg aggcgctggc gcaaagcggg cagctgatca aagtgcgggg aggggctatc
     2521 ccgcattccc ccaaccccta ttcttttaag gagagagtag agcggcatgc cgcggataaa
     2581 cagctgatgg cccgcaaagc cctcaccctg ctgcacgacg gacagacggt gctgatggat
     2641 ggcggtactt ccacgctggc gctggtaaaa ctgttgcccc cccagctacg gctcaccatc
     2701 attaccaaca gtgtgcccat cgtcacgcag ctgatagaac accctaccat tgaagtgatc
     2761 tttacgggcg ggcgtatcgg taaaaactca caaactgcca ccggcatgga cactatccgc
     2821 gccatgcaga agatccgcgc cgatctggct ttcgtgggta tctgcagcct gcatcccgaa
     2881 gccggtgtaa ctggcctgga ccttgaagag gcagatgtaa aaagtgtgat gatagaagcg
     2941 gccaataaaa ttgttgcgct ggccaccagc gataaaatgg acacggcaga gccgtttaaa
     3001 gtctgtgaaa ttaccgggat agatgtgatt gtgacggata aaccgcaact gcccttgttt
     3061 aagccttacc aggacctggg aatacaggtg atataacgtt aaacggaaac cttacttgaa
     3121 tttacacaac gatgttacag gatttatcga taccggtgat acataagaga ggcacccgca
     3181 ttgcggtaag cgcgttgttt ttcctgaccg gattgtgttt tgccagctgg gcatcacgta
     3241 ttccggatat acagcaatcc ctgcacctca acgatgcggg acttggcagc gtgctgctgg
     3301 ccctgccggt aggatcgctg atttccctgc cggtagcggg tgtcctggtg tcccgctttg
     3361 gcagcaagca ggtgctgatc attgctgcgg tggcgtatgc cgctatttta ccggtactgg
     3421 gcctcgcgaa agccccctgg gaactgatct cttttctcgt gtttttcggc ttctgcggca
     3481 acctggccaa tattgcggtc aacacccagg cggtagctgt agaagcaatg tacggccgct
     3541 ctatcatggc atcctttcat gggctgtgga gtgtggcggg tttcaccggc gccgctatcg
     3601 gtgcggccat gagcggactg catctgcagc cggtatatca tttcctgcta atcaccggta
     3661 tttcctggac gctggtactg ctcacgatgc ggcatattgt acagcaggat aataatgtac
     3721 aggccaatca gccactgttt gttaagcctg accgcttttt gctgacgctg ggcatcattg
     3781 ctatgtgctc tatgatatgc gagggtacta tgtttgactg gagcggggtg tattttcgcc
     3841 gtgtagtgaa ggtagatgaa ggactgggag gcgccggtta tgccgccttt atgggcacca
     3901 tggcttccgg ccgctttgtg gccgactgga tgataacgcg attgggtaca cgaaaaatgc
     3961 tcatcatcag cggaacactt acagctgccg gcttgctggt agcggtggct ttcccctacc
     4021 tggtgagcgc tacgctgggc tttatgctgg ttggcgcggg tgtttctgcc gtagtgccgc
     4081 tggtgtacag cgctgccggc aaatcgtcgg tattgtcgcc gggaatggcg ctggcggcgg
     4141 tttccaccat tggctacctg ggctttcttt ttggccctcc gctgattggc tttgtggcgc
     4201 aggctaccag cctcgcggtg tctttctcgc tgatcgccgt catgggcgct gccatcgcga
     4261 ttatgtccac ccggctgaag ctgtaacggc ttacagtcgg tgaggctcag gaaggcaaca
     4321 gaagttgtgg cttccatgtc ttaagcgata acagcgtacg gggcttcggc cctgggtcat
     4381 gacgcttcga aggtggaagt ggtgctgaaa aacatctctt ctccgctgta atcgatgatc
     4441 aggagccagt tgcccacagc tggcctcact tccggtaacc gcagtgcaga caaggcttcc
     4501 agcagcggtc cgggttcatg ttcaaaaggg atatatctca cctttaaagc ggcgtcctgc
     4561 tgcttcggta aaaatttcaa agcattgatg gcggtttcca tccgcaatat ttcaggcagg
     4621 taaagtacct gcaggcgccc ttgtattatt tgttgttcca ggtaatcagc aaaaccttca
     4681 atttcccgtt tgaactggag atcggattgc cggcaggcct cccagaaggc ggtggccagc
     4741 ggcatgagcc ggttgcccag cagcagacag gtatagggca gaagcgtata gataggcgtt
     4801 atacggttca cccggtacag ggtgcagttg accgacatgc cccgctggaa cacgaccgat
     4861 tccagtcgtt ttctttcgcg gtcggtgagg tcataggatg cgaagactgc atccggctgt
     4921 tgtcgggctt ccacgcatag ctcgggggaa gcgatgagtg cggcgagtgc ctgctgaaag
     4981 gagaggagtg acatggctgt tcacgtatga tattgattcc atactgcttt ggctctgttc
     5041 agctcgcggg tgatcccgtc gaactgcagc agatggaaat aggattcatg aaattcgaag
     5101 gtgatgccgc aaaggttggg tactaacggc aacgtatact cgagaagttc ccagacggct
     5161 tccggacagg ggcctgcatg ggagtcggta tacataccgg ccatttcatt gccgccggcg
     5221 atgtgtatct ccacaacttt gccgaggtcc agtgcggcaa tgaagctgcg tggatcgaag
     5281 ccatggttca ccgcattcgt atatacgttg tggatatcga gcaggaggcc gcaggcggtg
     5341 tcctgcgaca gttcgttgag gaaatccgtt tcggaaagct cctgttccgg caggtcaatg
     5401 aagtagacgt tgttttctac caggaaaggt gctctgatac tgcggctgat agtgttgatg
     5461 cggccgtcga tcatatccag cacttcgtaa tcgtagggca cgggaacggc cataccggca
     5521 ttgcgttcct gctgatgttc atcatgtact tttacgaaag agaggtgatc gctgtgccac
     5581 acaaaggaga agcgctgatg ccattcttcc attttgtgga gataggccat atcgaagatg
     5641 ccggcactgc ccagggagta ggagatgttg tgtgccgtga gcggataacg ggcagcgagt
     5701 ttatgaagca cgtccatcca gctgtctatt tcttcaaagc ggccggggtg gccgttgccc
     5761 aggtctgtcc agaacatgtc cggaataatt tccacataat cgcagcaggt agcggggctg
     5821 tcgagatata gttccaggga aggattgtac aataaaccca cgcccagccg gggaatagtt
     5881 ttttcataca accggctgct gtagccggta agcttagcag gatacatggt agggaatgtt
     5941 taaaaagccc cgctccggag aacggggcgg tgatacgtta gtggccgatg acagtgcctt
     6001 tgatggtacc tttgatggtc gccattttgt cgaggtctac tttcataaca tgttccagtt
     6061 cttcccggat gttaaagtgg acgccggaca ggcaggcctg acagccacgg gggttaattt
     6121 tcgaaattac cagttcctgt aatctggcga tgtcggccat cttcgtgcct ttaggcacgg
     6181 tgaggtttac ctggccgtca gttccgtagt gaacttctgc tgtacgcatg acatgtggtt
     6241 tttggggtga taaatgatag atataaaaac gacagatata aacgaataaa aatgctgctc
     6301 aattgatgcc ggtcactttg gggtatgtac taacaggatc taaaggtagg atattccggg
     6361 atgatagcgc aacgtatttg tacggaaaaa aaaccggcgt gtttctgctg aaatccgcct
     6421 ctgccgtaat gttttataca ataattattg tatgtaaaaa aagcattcta tcatgccgtc
     6481 tccaaaattc tttcataaaa aatcaaattt aattccatta ttaaatttca aatcacgtaa
     6541 ctttgcacga tttttttggt ccctcgtacg gcattaaaat caatgtggtt tttcattttc
     6601 aatagattac aaaaatgcca aaagactcat ctatcaaatc tgtcctcatt atcggatctg
     6661 gtcccattat tattggtcag gcttgcgaat ttgactattc tggttcccag gcagcacgtt
     6721 cgttgcggga agaaggaatt aaagtgattt tgattaattc caacccggct accatcatga
     6781 cggaccctat gatggccgat aaggtttatt tgctcccatt aaccgtggaa agcattgagc
     6841 agattctgga agaaaaccag attgatgccg tattgcctac catgggtggt caaacagcgc
     6901 tgaacctttg taaagaggta gatgagctgg gaatttggga gaaatttaat gttcgcctga
     6961 tcggggtaga catcaaagcg atcgacaaag cggaagaccg tgaacagttc cgccagtgga
     7021 tgctccggat cggtattccg gtagctcctg ccaaaacggc caactccttt ctggaaggta
     7081 aagagtttgc acaggagata ggattcccgt tggtaatccg tccttctttc accctcggcg
     7141 gtaccggcgg cggtttcgta cacagcaaag acgagctgga cgaagcgctg gaccgtggcc
     7201 tgaaagcgtc tcccattcac gaagtactgg tggagaaagc ggtgctggga tggaaggaat
     7261 acgaactgga actgctgcgc gacaagaacg acaacgtggt gatcatctgt acggtggaaa
     7321 acctggaccc gatgggtatc cataccggcg actccatcac cgtggcccct gccatgaccc
     7381 tgagcgatac cgctttccag gacatgcgta acaaagccat gatgatgatg cgcgacctgg
     7441 gtaacttcgc cggtggttgt aacgtacagt tctccctgaa cccggaaaat gaggaactga
     7501 tcgccatcga aatcaacccg cgtgtgagcc gctcttctgc gctggcgtcc aaagctaccg
     7561 gttatccgat tgcgaaaatc gccgccaaac tggcgatcgg ttacaccctc gatgaactgg
     7621 aaaaccagat caccaaaacc acttccgctt tctttgaacc cgcgctggac tacgttatcg
     7681 taaaaatgcc acgctggaac ttcgataaat ttaaaggcgc agacgatacg ctgggcctcc
     7741 agatgaaatc agtaggtgaa gtaatggcta tcggccgcac cttccctgaa gccttgcaga
     7801 aagcctgcca gagcctcgaa aacgatgcgc tcggcctcgg ctactacggc aagtcactga
     7861 tgaaatctga acaactcatc gaaaaactga aacgtccgac ctgggaccgc atcttccgta
     7921 ttaaagatgc cctgatggcc ggcgcttctg taaaacatat tcaccagcag acttacatcg
     7981 accgctggtt cctccaccag atacaggata tcgtaaacct ggaaaaacaa ctgggcgagc
     8041 acgatctgga aagcgttccg gctgatatgc tggctgacgc caagaagctg ggcttctctg
     8101 atgcccagct ggcggttatc ttcggcaact gtgaagaaga agaagtttac gaaaagagaa
     8161 aagccaacgg cattgtacgg acttacaaaa tggtagacac ctgcgccgct gagtttgaag
     8221 caaaaacacc ttacttctac tctactttcg ataccgaaaa cgaaagcaag gtaactgacc
     8281 gtaaaaaaat catcgtactg ggttccggcc ctaacaggat tggccagggc attgagtttg
     8341 actactgctg cacccacggt ttgcaggcga tccaggattg cggttatgaa gccatcatgg
     8401 tcaactgtaa ccctgaaacc gtatccaccg acttcgacat ggccgataag ctgtacttcg
     8461 agccggtctt ctgggagcac ctgtgggaaa tcatcgagct ggaaaaaccg gaaggcgtga
     8521 tcgttcagct gggtggtcag acagcgctga aactggcaaa acgcctggaa gaaaaaggta
     8581 tcaaaatcat cggtacttct ttcgacagca tggacatcgc ggaagaccgt ggtcgtttct
     8641 ccgatatgct gaaagacctc ggtattcctt atccgaaata tggtaccgcc tacaatacag
     8701 acgatgcgat cgaagtggcg aaagaagtag gttatccggt actggtacgt ccgtcttatg
     8761 tactgggcgg ccagcggatg cgtatcgtga tcaacgagga agaactggaa caatctgtat
     8821 taagcctgct gcgtcacctg ccgggcaata agatcctgat cgaccacttc ctggaccgtt
     8881 gccaggaggc tgaaatcgac ggtatctttg acggtacgga ttttcacgtg atgggtgtta
     8941 tggagcacat tgaacctgca ggtatccaca gtggtgacag ccacgcgttg ctgccggcct
     9001 tcaaccttac gccgattgaa gtgaccacca tggaatacta cgcggaaaaa attgcccgcg
     9061 cattgaatat ccgtggtctg atcaacattc agttcgcggt gaaagacggc caggtgtatg
     9121 tgatcgaagc caacccgcgc gcttcccgca ccacaccgtt tatcgccaaa gcttaccagg
     9181 tgccttacct gaacatcgct accaaagtga tgatcggaga taaaaaacta aaagacttca
     9241 aaattgaaaa gaaactgagc ggctttgcca tcaaggaacc agtgttctct ttcaataagt
     9301 tcccgggcgt gaataaagaa ctcggccctg aaatgaagtc caccggtgaa gcgatccgct
     9361 ttatcaaaga cctgagggat ccttacttcc gtcagttgta taaagagaag agcatgtacc
     9421 tgtctaaata aaacaggtcg caccataaaa acaaaagccc gtcaatattg tgttgacggg
     9481 cttttttgtt ttatctttta agtgtgacag ctataaaata acagagcctg ataaagatca
     9541 ggctccttct tttccctcaa aataaccatt aaagacacga ctattgaatc ttgatacgac
     9601 acaaatagcg tgaccggtaa tgcattttac aaataatatt atatttaaag aagatgttaa
     9661 ctaatcaata acagattcga gaagttaata tatttataat attgatattt aacatattaa
     9721 acaaatacga ttttgttaac ctaaattatc ttaacacatc ctgaatcaaa aattacctag
     9781 ttatcatatc tttttcggat atgctgtttt tgcgtttttt ggacggttta atttccggat
     9841 gtcggaagat caaaagttga ccctctttta tgcagtttga atcatccatg tttgttgcag
     9901 catgttggaa acgtgcgccc tttctgcgtt taacgcctcc gttattaacg ggcatctgta
     9961 tgcagttatc caatcctctt tcagcacagt acctgcatat ccttatgctg tcggcttttg
    10021 ccttgttgtt gctgatacga ttgctgccgg ttgtataccg ttatcattat gcatgggcgg
    10081 caggtattcc cgtgcttatc ctgttgtatt gcagtggagc gttgctgctg gtttctgccg
    10141 gtatccggca ggacgacacg tgtttttccg caccaccgga cagtgccacg tattggttgg
    10201 caaaggtaga agcgccttta caggacaaac cccgttcccg taaaacatgg ctggccgtta
    10261 ccgccacctg cacgcaggga cgctggcggg catcgaaggg acgtttattg gcctatttta
    10321 gccgggatag tgcatcatcc ggtttggtgt acggcgcagt ggtattgctg gctaaaaagc
    10381 cggttaaaat caccaatagc ggtaatcccg gtgggtttga ttaccagcgt tactgtgctg
    10441 cacaacagct gtatcaccag gtattcctga aagcgggcga ctaccggcag ctgtcgcgtc
    10501 cgccgcttca tgaccttacc tttttcctgc tccaggcccg tgagttttgt ctcggtcagc
    10561 taaagattta tatcggcaac ggtccggagg cgggcatggc agaagccctg ctgatcggct
    10621 accgccagga cctggacccc gaagtggtca gcgcctatag caacaccggc attgtacata
    10681 tcatcgccat ttccggcatg cacctggctt tgttgtacgg ctccctgcta tggctgctgc
    10741 gttggctgcc cgcccgccgc gcggcgaatg tggtccgggc agtggtactg ctggccgtgt
    10801 tatggggctt cgccctgctg acaggcgcgt ctgcatcggt attacgggcg gcaatgatgt
    10861 tctccggcat cacggtgggc aactggttgc ttggcagaaa agccagtacc tacaacatgc
    10921 tggccgc
//
