LOCUS       NZ_FTMW01000005        22954 bp    DNA     linear   CON 22-JUN-2024
DEFINITION  Bacillus subtilis strain RU36A, whole genome shotgun sequence.
ACCESSION   NZ_FTMW01000005
VERSION     NZ_FTMW01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JAN-2017) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900156365.1-RS_2024_06_22
            Annotation Date                   :: 06/22/2024 02:00:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,232
            CDSs (total)                      :: 4,119
            Genes (coding)                    :: 3,974
            CDSs (with protein)               :: 3,974
            Genes (RNA)                       :: 113
            rRNAs                             :: 9, 7, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 1 (5S, 16S)
            partial rRNAs                     :: 6, 10 (16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 145
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 145
            Pseudo Genes (frameshifted)       :: 89 of 145
            Pseudo Genes (incomplete)         :: 67 of 145
            Pseudo Genes (internal stop)      :: 30 of 145
            Pseudo Genes (multiple problems)  :: 33 of 145
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:06:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 26575
            Orig. end                         :: 49529
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FTMW01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22954
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..22954
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="interleaved"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22954
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12954](+)"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12954
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     protocluster    235..21467
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10234:11467](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10235..11467
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
     misc_feature    complement(330..344)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.39"
                     /tool="antismash"
     misc_feature    complement(388..403)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 22.91"
                     /tool="antismash"
     misc_feature    complement(1006..1026)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.59"
                     /tool="antismash"
     misc_feature    complement(1175..1191)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 23.78"
                     /tool="antismash"
     gene            1466..2983
                     /gene="mpsA"
                     /locus_tag="BW968_RS16060"
                     /old_locus_tag="SAMN05878487_3220"
     CDS             1466..2983
                     /EC_number="1.6.5.9"
                     /codon_start=1
                     /gene="mpsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388064.1"
                     /locus_tag="BW968_RS16060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3220"
                     /product="NADH dehydrogenase subunit 5"
                     /protein_id="WP_076458334.1"
                     /transl_table=11
                     /translation="MLVSLSLSSLLTLFFIMLMASGISGLLFLHPRVPLSFVRIHIGIL
                     ALPLLVSLLILANSGVSGNVGPWHLDSLACLMTFFVLAIGFIIQRFSVRYLMGDRSYRK
                     YFALFTFTTGAASMTWLSGDLRLMVLFWGATLVGLTLLIRLNSAWQVASEAAKISGRLF
                     LLSWFSLFFAMMWLFHATGQWQLSLVVTNESIAGLGEWERTGIQLLIVLAVIIPAGQWP
                     FQRWLVESIVAPTPVSAIMHAGLVNAGGIILTRFSPLFHGGIASIILLLLAGISVLIGT
                     GISLVQVDYKRQLVGSTIGQMGFMLIQCALGAYIAAIIHLILHGLFKATLFLQAGSAVG
                     RHEVSARTNERTSYLWVMAGRILSLVIGVAFWLTAPGDGYHLISALILGWSLSVSWTQL
                     VAFGEGRIGRIAGLTVLGGAALVYFIIHNLFYKWLHTTIFQSVQPPMSAVMIVVCLLLF
                     GSALGTWVARHRSSVFFAVLYLWLVRLGEAKPKSVESHPDYLKQYIS"
     gene            2998..5613
                     /gene="mpsB"
                     /locus_tag="BW968_RS16065"
                     /old_locus_tag="SAMN05878487_3221"
     CDS             2998..5613
                     /codon_start=1
                     /gene="mpsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388065.2"
                     /locus_tag="BW968_RS16065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3221"
                     /product="YbcC family protein"
                     /protein_id="WP_069703997.1"
                     /transl_table=11
                     /translation="MGITSVLTKDNVNKIDTDIDVQERDLNVFITSASRVIAPLWPIST
                     FAARNPWMGLENQPFDQVASWLKNTRDVDIYPSASMIRSAKNKGEIDEDFVEMGLQRWL
                     DSHSYHIPRDVAERFCHAALKLDPLPSDLLSSHELEKLVSECSGLDHIENVFMQPLSSY
                     IENQDGERLVNILDHHVIKWSKLYLDDSQAGWTMPNREEGFYRAWQHLIQYDPALSKKQ
                     RERVKGWPKEAHLALQEALFALEIPESEIQTYLEGHLLSLPGWAGMMLWRSQQSSHEHA
                     LLTEYLAVRISMEWALIKPYLPLTNERSKKTISIAPLIAAWIHWGGLTLEEWSQMTAIE
                     QNEYLSFAYSFDEKLRKKLWLEAWEQTYTDRLSQKIISKQCETGGKKSALAQLAFCIDV
                     RSEPFRRQLEKEGPFETIGIAGFFGVPIATCELGSKHSHASLPIIQKPQNKIKEFADED
                     VFKKYNQRKQAIHSLSHTFKTMKQNALSSLLLPELSGPWLTLQMAARSFVPRKAGRFIR
                     NLREAWLRKPDTKLSLHHDATEAEMPVGFTDEEKVNYARQALKMMGLTENIAPLVVICG
                     HGSQSTNNPYSAALDCGACGGAAGGFNARVLAALCNLSEVREALLAEGIQIPEDTVFAA
                     AEHNTTVDELHWLYVPELSEAAQEAFEQIEAVMPKVRHHVNAERLAQLPNFQSKLKNPK
                     AEANRFAEDWSEIRPEWGLARNAAFIIGKRELTQDCDLEGRAFLHNYDWKQDESGELLA
                     NIIAGPGTVAQWINLQYYASTVAPHYYGSGNKATQTVTAGLGVMQGNASDLLAGLPWQS
                     VMESDHEAYHSPLRLLILIQAPREYVERLLNNDSAFLQKVQNGWVRLASLDPEGCWESW
                     "
     gene            5690..6217
                     /gene="ybcF"
                     /locus_tag="BW968_RS16070"
                     /old_locus_tag="SAMN05878487_3222"
     CDS             5690..6217
                     /codon_start=1
                     /gene="ybcF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388067.1"
                     /locus_tag="BW968_RS16070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3222"
                     /product="carbonic anhydrase"
                     /protein_id="WP_069703996.1"
                     /transl_table=11
                     /translation="MNVNQNKKVLFLTDIENGLEPILQEATNTSAENMLTIQSYGASIS
                     HPYGEIMRSVIFAIYQEDVEEIFVVGTKDKKTFAGNGLTQLETMKDKIQTLDYLFQNCK
                     PEFLGGTVDEWLNENSSDTIEKSVDMIRHHPLVPSHVKVRGLLVNHKDGKPSIMEGPDA
                     KTGQAIPDHCLS"
     gene            6281..6571
                     /gene="ybcH"
                     /locus_tag="BW968_RS16075"
                     /old_locus_tag="SAMN05878487_3224"
     CDS             6281..6571
                     /codon_start=1
                     /gene="ybcH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388068.1"
                     /locus_tag="BW968_RS16075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3224"
                     /product="DUF6407 family protein"
                     /protein_id="WP_069703995.1"
                     /transl_table=11
                     /translation="MSANLTDFVTKTIEDMNSFDRENMECMKKLIRKAIDFYHLKSYEE
                     VEKTHSGNVRFLHVHSMMEENMLSKMIVVTRNGKTDLDIEGVYEGYVVREY"
     gene            6628..7002
                     /gene="ybcI"
                     /locus_tag="BW968_RS16080"
                     /old_locus_tag="SAMN05878487_3225"
     CDS             6628..7002
                     /codon_start=1
                     /gene="ybcI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388069.1"
                     /locus_tag="BW968_RS16080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3225"
                     /product="DUF2294 domain-containing protein"
                     /protein_id="WP_003246482.1"
                     /transl_table=11
                     /translation="MKKSKGSIESEISKSITQWEKDYLGRGSVSVKTDILRDMIIVNLK
                     GILTPAEYVVCGSKEGMLSIKQTRSELVESGIEGLKDIILKITGEKVKSFHTDLSSRTG
                     ERVMVFKLCNDLEKNLEKIL"
     gene            7487..7789
                     /gene="ybzH"
                     /locus_tag="BW968_RS16085"
                     /old_locus_tag="SAMN05878487_3226"
     CDS             7487..7789
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="ybzH"
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097670.1"
                     /locus_tag="BW968_RS16085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3226"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_003234907.1"
                     /transl_table=11
                     /translation="MEPIEVFKALSNESRLQILQWLKEPDRHFAPHEGIDMNTIGVCVS
                     QITDKLKMTQSTASQYLTILLRAGLIKAERIGKYTYYKRDEEAIGKLADFLKTEI"
     gene            7916..9088
                     /gene="ybcL"
                     /locus_tag="BW968_RS16090"
                     /old_locus_tag="SAMN05878487_3227"
     CDS             7916..9088
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybcL"
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388070.1"
                     /locus_tag="BW968_RS16090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3227"
                     /product="MFS transporter"
                     /protein_id="WP_029726935.1"
                     /transl_table=11
                     /translation="MSNTWKIYILAIVSFLVGTSEYIISGILDQIAHTLGITLAAAGQL
                     ITIFSLVYALSTPILMALTASMDRRKLMMYALGLFVFGNVLAFVLPGYGWFIAARIIMA
                     MGAGVVVVTALTIAAKIASEGKQGSAIATVVMGFTASLIIGVPLGRMIAVALGWKSVFG
                     AIALLGLIAMVVIFFTLPHTEGDKPVPLLQQLALFKKRKVAMGLSITFFWLGGYSVAYT
                     YLSPYLLNISGINGKLLSGVLLIFGIASLVGSKFGGYSTDKWGVPFTLVGGMTLHIVTL
                     ILLSLVTHSYIGVLVILILWSFAAWSTGPTQQFHLATIEPEMSGVLLSMNQSMMQFAMA
                     VGAGIGGVFVENVSLASITWVGALGIMIAIITSLRIFHSQPKQTLKDINQ"
     gene            <9189..9529
                     /locus_tag="BW968_RS21810"
                     /old_locus_tag="SAMN05878487_3228"
                     /pseudo=""
     CDS             <9189..9529
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003223659.1"
                     /locus_tag="BW968_RS21810"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3228"
                     /product="glutamine--fructose-6-phosphate aminotransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VCVEGALKLKGIS"
     gene            10001..10168
                     /gene="skfA"
                     /locus_tag="BW968_RS16100"
                     /old_locus_tag="SAMN05878487_3229"
     CDS             10001..10168
                     /codon_start=1
                     /gene="skfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: TIGR04404"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388072.1"
                     /locus_tag="BW968_RS16100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3229"
                     /product="sporulation killing factor"
                     /protein_id="WP_009966416.1"
                     /sec_met_domain="TIGR04404 (E-value: 4.7e-38, bitscore:
                     123.7, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRVC
                     ALPHPAMRAI"
     aSDomain        10235..10537
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BW968_RS16105_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="1.70E-16"
                     /identifier="RREFam021.1"
                     /label="BW968_RS16105"
                     /locus_tag="BW968_RS16105"
                     /protein_end="101"
                     /protein_start="0"
                     /score="51.4"
                     /tool="antismash"
                     /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSL"
     gene            10235..11467
                     /gene="skfB"
                     /locus_tag="BW968_RS16105"
                     /old_locus_tag="SAMN05878487_3230"
     CDS             10235..11467
                     /codon_start=1
                     /gene="skfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388073.2"
                     /locus_tag="BW968_RS16105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3230"
                     /product="sporulation killing factor system radical SAM
                     maturase"
                     /protein_id="WP_003234902.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     2.6e-15, bitscore: 51.4, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 7.9e-32, bitscore:
                     105.3, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.8e-22, bitscore: 74.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5e-07, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 5.2e-06, bitscore: 21.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSLDSY
                     LPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTGGEA
                     KLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNTHDQL
                     RGRKGGFKESMNTIKKLSEANIPVIVAMTINESNADEVSDVVEQCANAGAFIFRAGKTL
                     SVGRATEGFKALDIDFEEMVQIQLREARHKWGDRLNIIDWEHEESSFTTDFCTPGYLAW
                     YIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIELSEPDLP
                     FQKEVKAGIQE"
     gene            11464..12954
                     /gene="skfC"
                     /locus_tag="BW968_RS16110"
                     /old_locus_tag="SAMN05878487_3231"
     CDS             11464..12954
                     /codon_start=1
                     /gene="skfC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: skfc"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097671.1"
                     /locus_tag="BW968_RS16110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3231"
                     /product="sporulation killing factor biosynthesis protein
                     SkfC"
                     /protein_id="WP_076458335.1"
                     /sec_met_domain="skfc (E-value: 1.2e-288, bitscore: 952.7,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Abi (E-value: 9.6e-14, bitscore: 46.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLSLVFWSILAVVGLLLFIKFKPPTIASLLLSKDEAKEISIQF
                     IKEFVGIEVENWDFYSVYWYDHDTVNKLHHLGILKKNRKVLYDVGLVESWRVRFVHQNQ
                     SFVVGVNANREITFFYADVPKKTLSGKFEQVSPETLKQRLMASPDGLWSRANMTGTGKK
                     EEDFREVSTYWYIAEAGDIRLKVTVELQGGRISYIGTEQEILTDQMSKVIRDEQVESTF
                     GVSGMLGSALAMILAILILVFMDVQTSIIFSLVLGLLIIICQSLTLKEDIQLTIVNAYD
                     ARMSVKTVSLLGILSTLLTGLLTGFVVFICSLAGNALAGDFGWKTFEQPIVQIFYGIGA
                     GLISLGVTSLLFNLLEKKQYLRISPELSNRTVFLSGFTFRQGLNMSIQSSIGEEVIYRL
                     LMIPVIWWMSGNILISIIVSSFLWAVMHQVTGYDPRWIRWLHLFIFGCFLGVLFIKFGF
                     ICVLVAHFIHNLVLVCMPLWQFKLQKHMHHDQPKHTSL"
     gene            12973..13695
                     /gene="skfE"
                     /locus_tag="BW968_RS16115"
                     /old_locus_tag="SAMN05878487_3232"
     CDS             12973..13695
                     /codon_start=1
                     /gene="skfE"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388077.1"
                     /locus_tag="BW968_RS16115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3232"
                     /product="sporulation killing factor ABC transporter
                     ATP-binding protein SkfE"
                     /protein_id="WP_076458336.1"
                     /transl_table=11
                     /translation="MQLMQVQNLSKCYRNGDGVEHLSFSIQRGEIVALLGPNGAGKTTT
                     IRCLTGLYKPDKGDILIEGSPPGDINVQKKVALIPDQPYLYPALTAAEHIQFRARGYHP
                     GKKDVKERVYHALKEVHLEEKANQLCGQLSRGQKQRVVLAGAIVQDALLYILDEPTVGL
                     DIPSKQWLSNWLKTKTDQGCSAFVSTHSLEFVIETADRVILIRDGKLMQDLYVPQFEEE
                     QAEWRKEVIRLLGEWSDE"
     gene            13688..15103
                     /gene="skfF"
                     /locus_tag="BW968_RS16120"
                     /old_locus_tag="SAMN05878487_3233"
     CDS             13688..15103
                     /codon_start=1
                     /gene="skfF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019257319.1"
                     /locus_tag="BW968_RS16120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3233"
                     /product="sporulation killing factor system integral
                     membrane protein"
                     /protein_id="WP_076458337.1"
                     /transl_table=11
                     /translation="MNNIISFLWLQSKRRFVSQGQEKKMPFLIMLLFVGAIGFQVSFVS
                     RSTTWDMSIAGWVLTGVFILYTAFGLFSNRLPSQMADIIWLYGTATSFSKVVYSVLFFS
                     VTWKALLWIISAIFGDVLIVLLSGDHINLLGRSIIFVGLFFIAEVWLMSVSCARTVKKM
                     KRVYVLVFLLMLGIYSICLYHFFFLQHSSGIWESIARFISGVGLVFDTLSPLYVVVFIG
                     IITVSFMTIAFTSRQVEMKESLVKEAEFWEEFQERQFGSGQIIQKPKTTWWGLQGLNGI
                     WSFLWLELLLFKKYLFFHSIHTVMLSGVFYVVIFMYPEWFYLLFFLIVSAVMLSSYYSG
                     IVRHSQSGTLHLFPGALWKKVIILELTNTVWLYILYCVSITFMAVGNLVYWYIYGLGIY
                     IWFMTIRLFAFTHTNRNDPRLSLPQYYKSFFMALGLSGICLYVIHLLTADWYTLVVVVC
                     IGSLSWCLFYRFR"
     gene            15150..15665
                     /gene="skfG"
                     /locus_tag="BW968_RS16125"
                     /old_locus_tag="SAMN05878487_3234"
     CDS             15150..15665
                     /codon_start=1
                     /gene="skfG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388079.2"
                     /locus_tag="BW968_RS16125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3234"
                     /product="sporulation killing factor biosynthesis/export
                     protein SkfG"
                     /protein_id="WP_076458338.1"
                     /transl_table=11
                     /translation="MNSNGDKLSLSVQNLANTNEITIVQAIGELKKSGKDAIPVLVEAL
                     KEEGSLCNIAAAVLGEFGEDASEAAEELSCLLKSHAEDTRMAAAISLMRIGKPSLPFVI
                     KIAKESEGQSCFWASWCIAWIDPSCIEPKMYKCLKYEHEHPSGIVAPFAAEEALGKLIA
                     FQLKDKED"
     gene            15670..16095
                     /gene="skfH"
                     /locus_tag="BW968_RS16130"
                     /old_locus_tag="SAMN05878487_3235"
     CDS             15670..16095
                     /codon_start=1
                     /gene="skfH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388080.2"
                     /locus_tag="BW968_RS16130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3235"
                     /product="sporulation killing factor biosynthesis/export
                     protein SkfH"
                     /protein_id="WP_003246390.1"
                     /transl_table=11
                     /translation="MKDEQMLTEWPSHLPWLNQSQNDFTFPSDTYLLLYFWSMSCPNCH
                     QLTDKVLQDIKDMNVKVIGVHVPYIEEEKSMEVVLTYALDRGLAIPIVLDQNYEIVTTC
                     HVQGIPSFCLLSQYGQIITKTMGDVGWDKMLKKIAGL"
     misc_feature    15688..15703
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.76"
                     /tool="antismash"
     gene            16344..17321
                     /gene="ybdG"
                     /locus_tag="BW968_RS16135"
                     /old_locus_tag="SAMN05878487_3236"
     CDS             16344..17321
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybdG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388081.2"
                     /locus_tag="BW968_RS16135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3236"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_076458339.1"
                     /sec_met_domain="PF00561 (E-value: 5.9e-08, bitscore: 27.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKEKG
                     TLVEVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFMPSAVYNPEVIRQSFLTDEEKEI
                     YKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKYAIQNR
                     KDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR"
     gene            17323..17994
                     /gene="ybdJ"
                     /locus_tag="BW968_RS16140"
                     /old_locus_tag="SAMN05878487_3237"
     CDS             17323..17994
                     /codon_start=1
                     /gene="ybdJ"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388082.1"
                     /locus_tag="BW968_RS16140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3237"
                     /product="two-component system response regulator YbdJ"
                     /protein_id="WP_076458340.1"
                     /transl_table=11
                     /translation="MKGYHILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQK
                     VDLVIMDVMLPGEDGYQMSAKIKELGLGIPVVFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVK
                     K"
     gene            17991..18977
                     /gene="ybdK"
                     /locus_tag="BW968_RS16145"
                     /old_locus_tag="SAMN05878487_3238"
                     /pseudo=""
     CDS             17991..18977
                     /codon_start=1
                     /gene="ybdK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003234894.1"
                     /locus_tag="BW968_RS16145"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3238"
                     /product="two-component system sensor histidine kinase
                     YbdK"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKLKTKYQLLLFTAVISVPMLLLAVSVLMSVIYDSMFKTMNHGMP
                     FHRSFAYPAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLE
                     DQCHGQAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDY
                     LYSMSGIELHYKPADQDVIWMSNALWMQRLFDNIFQNTLKHSKAEKM"
     gene            19036..19299
                     /locus_tag="BW968_RS16150"
                     /old_locus_tag="SAMN05878487_3239"
     CDS             19036..19299
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097672.1"
                     /locus_tag="BW968_RS16150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3239"
                     /product="hypothetical protein"
                     /protein_id="WP_032724788.1"
                     /transl_table=11
                     /translation="MNIICLKKSSKRLSTSQAVLVTDIADIGITAAAGADIIAATAAAR
                     AKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD"
     gene            complement(19284..20054)
                     /gene="pkrD"
                     /locus_tag="BW968_RS16155"
                     /old_locus_tag="SAMN05878487_3240"
     CDS             complement(19284..20054)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pkrD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388085.1"
                     /locus_tag="BW968_RS16155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3240"
                     /product="protein kinase"
                     /protein_id="WP_076458341.1"
                     /sec_met_domain="Pkinase (E-value: 9.8e-33, bitscore:
                     108.3, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTDI
                     LTQTPYVLKQLRPTKAKKEKERVRFQQEIKLLKSIHHPQIPGFIDEFIIDGQAYYVMQF
                     IEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLC
                     LLDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTK
                     EVTLLLKRLLGIDEEYQHTASIREDLNRAIQSVT"
     gene            complement(20140..20997)
                     /locus_tag="BW968_RS16160"
                     /old_locus_tag="SAMN05878487_3241"
     CDS             complement(20140..20997)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388086.1"
                     /locus_tag="BW968_RS16160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3241"
                     /product="hypothetical protein"
                     /protein_id="WP_076458342.1"
                     /transl_table=11
                     /translation="MVKKWLIPFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIGY
                     WKYKNIDTTILEAGQDEAYFTFTANKGEKVYVRSTYQSAYTGMKIEIYDKNRIPVSQGT
                     EVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQFSG
                     VAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHLIMTN
                     ENNEWRRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKIDYEYDV
                     TKQF"
     misc_feature    21054..21063
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            21129..22313
                     /gene="ybdO"
                     /locus_tag="BW968_RS16165"
                     /old_locus_tag="SAMN05878487_3242"
     CDS             21129..22313
                     /codon_start=1
                     /gene="ybdO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_388087.1"
                     /locus_tag="BW968_RS16165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05878487_3242"
                     /product="DUF4885 domain-containing protein"
                     /protein_id="WP_076458343.1"
                     /transl_table=11
                     /translation="MRLNRQFIRTQLMAQNIWSKNAPAKRENATENPAAVLEKAYSRLK
                     SQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESDIR
                     IKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEWLFK
                     GKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTELTFT
                     ITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEAYQKYQ
                     AAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAISYYRSE
                     LSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGVNY"
     misc_feature    22374..22388
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.38"
                     /tool="antismash"
     misc_feature    22394..22407
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     misc_feature    22844..22858
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
ORIGIN
        1 gatagggaag gtttcagggg tatttcactc gaattatcaa ccttttgttg aattgggaga
       61 ggttaataaa ctgatacata aagaaaaaga caattctttt ccaagtgacc atacaatttt
      121 attcttctca tattgtattt cattctggct ctttaagaga ggctggtcaa ttttatgggt
      181 attgttagct gttcttgtgg gagtctcccg tatatgggtt ggggttcatt atccttttga
      241 tgttttagca ggagtattaa taagcctagc agtttcaact tttatatatt taacattccc
      301 taaactaaat attactcaaa ctgccatgaa aatttatgaa aaatgtgaaa acatacttct
      361 ttatcgcttc aaaaggaagg aaaacaagtc aaaaaacctt tagatttatt caacaatcgg
      421 gtgctaatgt tcaaaaaaac gtaacctaaa atgataaact cttttataaa gattccatct
      481 gtattcaaag ctgtagaatc cattttgatc tatctttttt tctatggatt ctttaaattt
      541 gccgtaaact gaaggttcat gtgttatttt tgatcaacct ttattttaaa gctacagttt
      601 tagccaaagg ggttttttat tttaaagatg gctatgttta attttacaga tatttaggat
      661 tgccataaga atatgaaaat attaaagaag atatttttaa ggaaagtgac atctatggag
      721 aagttgggga attctagcta taacactatc cacacagcta gttcaagttt cttggtcgtt
      781 aaggctgttg aaaataaagt aggaaccagt attcatttat agttcctaat tgaacccagt
      841 tatttactaa tcaagaaaat agaaaaatga ttataaaatt cttcttgtat ttctacaaaa
      901 aattaaagtg atagatatca taagccttgg ataaagattc aggatgtatt gaaagaagga
      961 tttgatactt cattctctgt attccaacat cttgacaatg tttaaaattt agcatatctt
     1021 atacttaact taataattgg ctcaggtgtt tattttcgtt tgttacatta ttaggtcttt
     1081 agcattcttt caactaatct tgacaggatg aaaaagtatc ctaatttaaa tggaagagga
     1141 acataagtaa attttatttg ataattaagc acctatatta taatgtaacg aagttcattc
     1201 ttttagaagg aagttaaaac atagcataag taaaataaca aataataagg tagcacttca
     1261 aaaaacttcg ctgaagttag ttgaagtgaa gccgacaatt ttcaggattc aatgatctaa
     1321 cataatcatt gaaattttga agttgtcggc ttttttgttg gaaaaaaata gagataaata
     1381 aaaattgaaa taaataataa acaaatatga tctgattgaa aggtcttttg accaataatg
     1441 agttttaaaa aagggagaat ttcgaatgtt agtttcgctg agtttgtcat cattattaac
     1501 attatttttt attatgctta tggcttctgg gataagtgga ctattgtttt tacatccgcg
     1561 agtacccttg agttttgttc gcattcatat tgggatcttg gctttaccac ttttggtttc
     1621 cttactgatt cttgccaata gtggtgtgag tggaaatgtt ggcccttggc acttagattc
     1681 cttagcttgt ttaatgactt tctttgttct tgcaattgga ttcatcattc agcgtttttc
     1741 tgtacgttac ttaatggggg atcgatctta tcgaaaatat tttgcgcttt ttactttcac
     1801 aacaggtgct gcttctatga catggttaag tggtgatctc cgcttgatgg ttctattttg
     1861 gggagcgact cttgttggat taaccttact tattaggtta aacagtgctt ggcaagtggc
     1921 tagtgaagca gccaaaattt ctggccggtt atttttgtta agttggtttt ctttgttttt
     1981 tgcgatgatg tggctttttc atgccacagg tcaatggcag ttatcattgg ttgtaacaaa
     2041 tgaaagtata gctgggctgg gagaatggga gagaacaggg attcagctat tgattgtact
     2101 ggcggtgatc attcctgcag gtcaatggcc gttccaaaga tggttggttg agtctattgt
     2161 tgctccaacc ccagtttctg caattatgca tgcaggttta gtaaatgctg gaggaataat
     2221 actaactcga ttttcacctc tatttcatgg tggtatcgct tcaattatct tacttctgct
     2281 tgctggcatt tctgtattga ttggaactgg aattagttta gtccaggttg attataaacg
     2341 ccagttagta ggctccacga ttggacaaat ggggtttatg ctcattcagt gtgcattagg
     2401 cgcctatata gcagccatta ttcatcttat tttacatggt ttattcaaag ctacgttgtt
     2461 tctacaagct ggttcagcag tagggcgtca tgaagtatcg gctcgcacta atgaaagaac
     2521 atcctattta tgggtcatgg ctggtcggat tttatcctta gttataggtg ttgctttttg
     2581 gctcactgct cctggagacg ggtatcactt aatcagtgcg ctgatcttag ggtggtcatt
     2641 gtccgtttct tggactcagc ttgtcgcttt tggagagggc cgaattggcc gaattgccgg
     2701 cttaactgtt ttaggaggag cagccctcgt atattttatc attcataacc ttttctataa
     2761 gtggctgcat acaaccattt ttcaaagtgt tcaacctcca atgtcagctg tcatgattgt
     2821 cgtatgtctc ttactatttg gcagtgcttt aggtacgtgg gttgctcgtc atcgttcttc
     2881 cgtttttttc gcggtactct atctttggtt agttcgatta ggtgaagcaa aaccaaagtc
     2941 agtagagagt cacccagact accttaaaca atatatttca taaggagcta atctgagatg
     3001 ggcattacat ccgtattaac gaaagataat gtaaacaaga tagatacaga tattgatgtt
     3061 caagaaaggg atcttaacgt tttcattaca tctgccagcc gagtgattgc gccactttgg
     3121 cctatttcta catttgctgc acgtaatccg tggatgggac ttgaaaacca accttttgat
     3181 caggttgcaa gttggttgaa aaacactcgt gatgttgata tataccctag tgcgtctatg
     3241 atccgttcag caaagaataa aggtgagatt gatgaagatt ttgtggaaat ggggctgcag
     3301 cgttggcttg attcacattc ctatcacatt ccacgggacg tggcagagcg attttgtcat
     3361 gctgcattaa agttagatcc cctgccttcc gaccttttat catcacatga gctggagaaa
     3421 ttagtaagtg aatgtagtgg attggatcat atcgagaatg tgtttatgca gccactaagt
     3481 tcgtatatag agaatcaaga tggtgaaagg ctagtcaata tactagatca tcatgtcatt
     3541 aagtggagta aattatatct tgatgactct caagcaggct ggacaatgcc taatcgtgag
     3601 gaaggtttct atcgtgcttg gcagcatctc attcaatatg atccagcact tagtaaaaag
     3661 cagcgagaaa gggtaaaagg ttggccgaaa gaggcacatt tggctttaca ggaagcctta
     3721 ttcgcactag aaatcccaga gtcagaaatc cagacttatc ttgaaggtca tttactttca
     3781 ttacctggat gggcagggat gatgctttgg cgctcccagc aatcgagcca cgaacatgca
     3841 ctcctaacag aatatttagc ggttcgaata tccatggagt gggctcttat aaagccatac
     3901 ttacctttga ctaatgaacg atctaagaaa acaatttcaa ttgctcccct tatagcagct
     3961 tggattcatt ggggtgggct tacattagaa gaatggtcac agatgacggc cattgaacaa
     4021 aacgaatatt tatcatttgc ctacagcttt gatgagaaac ttcgcaagaa actttggtta
     4081 gaagcttggg aacaaacgta cactgatcga ttaagccaga agatcatctc gaaacaatgt
     4141 gaaaccggcg gtaaaaaatc tgcattagct caattagcat tctgcatcga tgtacgatca
     4201 gaaccttttc gtcgtcaact agaaaaagaa ggcccgtttg aaacgattgg tattgctggt
     4261 ttcttcgggg tgccgattgc aacttgtgaa cttggcagta aacacagtca tgcttcctta
     4321 ccgatcatac aaaaaccgca aaataaaata aaagagttcg cagatgagga tgtattcaaa
     4381 aaatacaatc aacggaagca agcaattcat tctttaagcc atacctttaa aacgatgaag
     4441 cagaatgcgc tttcgagctt actactgcct gagctaagcg gaccttggct tactctgcaa
     4501 atggcagccc gtagctttgt gccaagaaag gcgggtcgtt tcattcgtaa tctccgtgag
     4561 gcttggttgc gcaaacctga tacaaaactc tcgcttcatc atgatgctac agaagcagaa
     4621 atgcctgtgg gttttactga tgaagaaaaa gtgaactatg ctcgccaagc attaaaaatg
     4681 atggggttaa cagaaaacat cgcacccttg gtcgtgatct gcgggcatgg cagtcaaagt
     4741 actaataatc cttattccgc agcccttgat tgtggtgcct gcggtggagc ggccggtgga
     4801 ttcaatgcta gagttttagc tgctttatgt aatctatcag aggtacgaga agctctttta
     4861 gctgaaggaa ttcaaattcc tgaggatacg gtttttgcag cagctgaaca taatacaaca
     4921 gtagatgaat tacattggct ttatgtacca gagctttccg aagctgcaca agaagcattt
     4981 gaacaaattg aagccgtgat gccgaaagtg agacatcatg taaacgcaga acgtctagcc
     5041 caattaccga atttccaatc gaagctaaaa aatccgaagg ctgaggcaaa ccgatttgcg
     5101 gaagattgga gtgagatacg tccggaatgg ggactggctc gtaatgccgc ttttattatc
     5161 ggtaaacgtg aactaactca ggattgtgat ttggaaggca gagcctttct ccataattat
     5221 gattggaagc aggatgaaag cggtgaactc ctagcaaata ttattgcagg acctggtact
     5281 gtagcccaat ggattaattt acaatattac gcatcaacgg tagcgcctca ttattatggc
     5341 agcggaaata aagcaactca aaccgttact gcaggtctcg gcgttatgca ggggaatgca
     5401 agcgatttgt tagccggact gccttggcaa tccgtcatgg aatcagatca cgaggcctat
     5461 cattctcctc ttcgtttatt gatactcatc caagcaccta gagaatatgt agaacggtta
     5521 ttaaataatg attcagcatt tctgcaaaaa gttcaaaatg gatgggtccg actggctagt
     5581 cttgatccag aaggatgttg ggaaagctgg taatgatgaa tctaagcatt tatcaaatgg
     5641 atttgttatt caaaataaaa atgataaaca taaggaagag gtgtgctgta tgaatgtaaa
     5701 ccaaaataaa aaagtattat ttttgacgga tattgaaaac ggtttggagc ctattttaca
     5761 agaagcgact aacacttctg cagagaatat gttgactata caaagctatg gtgccagtat
     5821 ttcacatcct tatggagaaa tcatgaggtc tgttattttt gcgatttacc aggaagatgt
     5881 tgaggagatt tttgtagtag gaacaaaaga taagaagact ttcgcaggta atggactaac
     5941 tcaacttgaa acaatgaaag ataaaataca aacattggat tatctctttc aaaattgcaa
     6001 gcctgaattt ttaggtggta cggtcgatga atggctaaat gaaaatagca gtgacaccat
     6061 tgaaaaaagt gttgatatga ttcgacatca tccactagtg ccgtcacatg ttaaagttcg
     6121 aggtttactt gttaatcata aggatggaaa accctcaatt atggagggtc ctgatgctaa
     6181 aacaggtcaa gccatacctg atcattgctt gtcatgatga aatgcaggtt caacttctaa
     6241 acgcacctat atatggagaa agcagttcta aggagattgt atgagcgcta atttaactga
     6301 ttttgtcacg aaaacaatag aggacatgaa ctcgtttgat cgtgaaaata tggaatgtat
     6361 gaaaaaacta attagaaaag caattgattt ttatcatctt aaatcttatg aagaagttga
     6421 gaaaacccat tcaggaaatg ttcgattttt gcatgtccac tctatgatgg aagaaaatat
     6481 gttatccaaa atgatagtgg tcacaagaaa cggtaaaact gatttggata ttgaaggtgt
     6541 atatgaagga tatgttgtaa gagaatatta atgagacgaa accacaaata gaatatgcaa
     6601 tttttttgct caggagatgt attagatatg aaaaaatcga aaggttctat tgaatcagag
     6661 atcagtaagt ccattactca atgggagaag gattatcttg ggcgggggtc tgtatctgtt
     6721 aagactgata tactgcggga catgatcatc gtcaatttaa aagggatttt aacaccagcc
     6781 gaatatgtag tttgtgggtc aaaagagggt atgttatcta tcaaacaaac tcgttcggag
     6841 ttagtcgaat caggtataga aggccttaag gatattatct taaaaataac cggagaaaaa
     6901 gtgaaaagtt ttcatactga tttaagctcc cggacaggtg aacgagtgat ggtgtttaaa
     6961 ttatgtaatg atctagagaa aaatttggaa aagatcttat aatctaaaga aaataaatgt
     7021 taagacggta tggaatttgt tgtgaattga acataaagaa ctgccgattc ttttgtttta
     7081 caattatggt atcattgata acttttattc atatcctaag cggacataaa gagatgtcaa
     7141 ttcatagtat actgtcttgt tattcctgtc gaaagatcta acatccgctg ttgttatgag
     7201 cggatgtttt tttacatcta ttttaaatac atgaatttga tgctggtgat tagtcacttg
     7261 aacaatatta aattcatttt aattgaaaac atccttgtca cctgccgggt tcccccaagt
     7321 gtttagtgac atgattatga gaccaatttc gtaaagcttg atgataaatt taagcggtga
     7381 acaaaattga tatgctgtct tcagtttcat ttcacggaat tagctttaat taaatatatc
     7441 caaaaaacgg attgacatat cgaaatataa cgatataata atcgatatgg aaccaattga
     7501 agtattcaaa gccttatcaa atgaatcaag gctgcaaatt ttacaatggc tgaaggagcc
     7561 cgatcgtcat tttgcacccc atgaagggat tgatatgaac acaatcgggg tatgtgtcag
     7621 tcaaataaca gacaaattga aaatgacgca atcgacagct tctcaatatc ttaccatcct
     7681 tttaagagcc ggcttgatta aggcggagcg tattggaaag tacacatatt acaaaagaga
     7741 tgaagaagcc attgggaaac ttgctgactt tcttaaaaca gagatataaa aataaacatc
     7801 aaaagatgtt tatttttaca ccatacatat cgacatatta cgatgtgttt attttttata
     7861 ataacatatc gataattcgt gatatgttta ttgataatta aggagtgaat gttttatgtc
     7921 taacacttgg aaaatttata ttttagccat tgtcagcttt ttagttggaa cctcagagta
     7981 catcatttcg ggaattttgg atcaaattgc tcatactctc gggatcactt tagctgccgc
     8041 gggccagctt attaccattt tctcacttgt atatgctctt tctacaccca tacttatggc
     8101 gttgacagca agtatggata gacgcaaatt gatgatgtat gccctaggtt tgtttgtgtt
     8161 cggtaatgtc ctggcttttg tactgcctgg ttatggatgg tttattgcag cgcggatcat
     8221 tatggcgatg ggagcaggtg tggttgttgt caccgcatta acgattgccg ctaagattgc
     8281 atcggaaggg aagcagggaa gtgccatcgc tacggtcgtg atgggattta ccgcttcttt
     8341 aatcattggt gttccgcttg gaagaatgat agcagtagca ttaggctgga agtctgtatt
     8401 tggagcaatt gctttgttgg gattgatcgc aatggtcgtt attttcttta ctcttccgca
     8461 tactgaaggg gataagcctg tgcctttgct tcaacagctt gctcttttca aaaaacggaa
     8521 agtggctatg ggattatcaa tcactttctt ctggctcgga ggatattctg ttgcttacac
     8581 ttatttgtca ccgtatctct tgaacatctc aggtataaat ggcaagctgc tcagtggtgt
     8641 tttgcttata tttggaattg ccagtttggt tggatcaaag tttgggggat atagcaccga
     8701 taaatgggga gtgcctttta cactcgttgg cgggatgacg ttgcatatcg tcacactgat
     8761 tcttctgtca cttgttactc attcctatat cggagtgttg gtgattctca tattatggtc
     8821 gtttgccgca tggtccaccg gtccgacaca gcaatttcac ctggctacaa tagaaccgga
     8881 aatgtcaggt gttttgctta gcatgaatca gtcaatgatg caattcgcca tggcggtcgg
     8941 cgcaggaata ggaggggttt ttgtggaaaa cgtatcattg gcctcgatta cctgggttgg
     9001 tgcgttaggg attatgattg ccattattac atcattgagg atttttcatt cacaacccaa
     9061 acagacgcta aaagatatca atcaataatt tcgaaagatc taacatccgc tcgttataca
     9121 agcgggtgtt ttttataagc gttcaaagtc agtccatgca tgagccttcc aagggccgac
     9181 atcgttctgt atgtgtcgaa ggcgcactga agctgaaagg gatttcttaa ggctttgccg
     9241 ctgaagtacg gtacgattgc cttgatcgaa cactggaaac acaagagaac gtaaacctga
     9301 acatccgcgt aaacgtcaag gaagttgcca cttagggagt aaacacttgc atcatctcgc
     9361 tgaaaggcct agacaatgcg gatgacatat tcgtattgcc ggaagtaaac acagcgcttg
     9421 ctctgtttcc gttgtcgatt gcagctgatt gcttactaat gctgccctgc atctcggttg
     9481 tgatgtcgat aagcagcgta accttgcgaa gagtgttact gtggagtaag atgtttaacc
     9541 cctctggata ttttagccga aggggttttt agtacagata tttgatttaa attacaggag
     9601 acttcattca tttaaccaaa gtcattgctt tcttaatcac taaagtttat ttgaaaataa
     9661 tctcttgatt taatttcctc gaagagattt tttgtcaatc tattaggcat cagaattttt
     9721 ataacataat ggatcgtctt tttgacgttt tgtttataga acaagaaaat attcaaaaca
     9781 taagtggaaa attaggggtg agctcctgtt tttctcgaga ggatagcttg tcagcttttc
     9841 tatttttaaa gggttaaaat attctattta tactaattaa tgtaattttt aggataatat
     9901 acaaaatccc ccttacttcg acaattgcaa tctggtatta tcgtatcgca tgggagctat
     9961 gtcaatagac tctatgtaaa aattgagagg aggtttactt atgaaaagaa accaaaaaga
    10021 atgggaatct gtgagtaaaa aaggacttat gaagccggga ggtacttcga ttgtgaaagc
    10081 tgctggctgt atgggctgtt gggcctcgaa gagtattgct atgacacgtg tttgtgcact
    10141 tccgcatcct gctatgagag ctatttaaca tttgagaata gggagttgag cgtatttgct
    10201 tatactcctt attttctctt aagggggatt ttatatgtca tatgatcgtg ttaaagattt
    10261 tgatttgcca gagttagcgg ttcatttaca gcctcatggt gctgtaatga ttgatagaaa
    10321 aagtatgttt tatttcagac tcagtggacg tggagcacag ttggcgtttc tgttatcaaa
    10381 aaacaaaaat cttcataaaa cggcacgtat ttgggagatt atgaaaaaag aagagatgag
    10441 tgctgaccaa ttaaaagaag agcttagtgc ccatccattt acggaggctt ggacggaagg
    10501 gctgttagat cagcctttac acgtttcggg ttcgctagat tcatatttac ctattagttg
    10561 taccttgcag ttgacaaatg cttgtaattt aagctgttcg ttttgctatg ccagctcagg
    10621 taaaccatat cctgaggaac tatctagtga acaatggata ttggttatgc aaaagttagc
    10681 agcccatgga gttgctgata ttacgctgac cgggggtgaa gcaaagctga tcaaagggtt
    10741 taaagaatta gtcgttgttg caagttcgtt gtttaccaat gtgaatgtat ttagtaatgg
    10801 attgaactgg cgagatgaag aagttgaatt acttagtcac ttaggcaatg tttctgtaca
    10861 gattagtatt gatggtatgg ataatacaca tgaccaatta agaggcagaa aaggcggctt
    10921 taaagaaagt atgaatacca ttaaaaaatt atcagaagca aacattccag tgattgtcgc
    10981 tatgaccatt aatgagtcca atgctgatga agtatcagat gtggtggagc aatgtgccaa
    11041 tgcgggtgct tttatctttc gtgcaggaaa aacgttatct gttggacgtg cgacagaagg
    11101 ctttaaggct ttggatattg attttgaaga aatggttcaa atacagctta gggaagcacg
    11161 tcataaatgg ggagatcgcc tgaacataat tgattgggag cacgaagaga gttcgttcac
    11221 aacagatttt tgtacaccag gatatcttgc ttggtatata agagcagatg gatacgtaac
    11281 tccttgccaa ttagaagatt tgccgctagg gcatatttta gaagatagca tggctgacat
    11341 tggttcacct gctcgtttgc ttcagttaaa atgtgaagca aaaaattgca aatgtatagg
    11401 gaaaattgag ctatctgaac cggacttacc ttttcaaaaa gaagtcaagg cagggattca
    11461 ggaatgaata gtctatcatt ggtgttctgg agtattttag cagttgttgg attactgtta
    11521 tttattaaat tcaaaccccc aacaattgct tcactactct taagcaaaga tgaggcaaaa
    11581 gaaataagca ttcaatttat aaaagagttt gttgggatag aagtagagaa ctgggatttt
    11641 tattcagtat attggtatga ccacgataca gtaaataaac ttcatcactt aggcatactt
    11701 aagaaaaata gaaaggtttt atatgatgtt gggttggtcg aatcatggag agtccgtttc
    11761 gttcaccaga atcaatcatt tgtagttggt gtcaatgcca atcgagaaat cacttttttt
    11821 tatgcggatg ttccgaaaaa aaccctttcg gggaagtttg aacaagtttc tccagagaca
    11881 ctcaagcaga ggttaatggc ttcacctgat ggactttggt ctagagcaaa tatgactggt
    11941 actggtaaaa aagaggagga ttttcgcgag gtcagtactt attggtacat agcggaagcg
    12001 ggagatattc ggctcaaagt gactgttgaa ttacagggcg gccgaatttc ttatattggt
    12061 actgaacaag aaatactaac agatcaaatg agtaaagtca ttcgagatga acaagtggaa
    12121 tcgacattcg gagtatctgg tatgctgggt tcagctttag cgatgatcct tgcgattctc
    12181 atccttgtat ttatggatgt gcaaacaagc ataatcttca gtcttgttct gggtttgttg
    12241 attataatat gccagtcatt gacgctgaaa gaagatattc aattaacaat tgtaaatgct
    12301 tatgatgcaa gaatgagtgt caaaacggtc agtttattag gtattttgtc tacacttctt
    12361 acaggattat taacaggatt tgtagtattt atatgttcat tggcaggaaa tgcgcttgct
    12421 ggtgattttg gatggaaaac gtttgaacaa ccaatagttc agattttcta tggaatagga
    12481 gcagggctca ttagtttagg agtgacttct ctgctgttta acttattgga gaaaaagcaa
    12541 tatttacgaa tttcacctga gctttctaac cgaactgtct ttctatcagg ttttaccttt
    12601 aggcaaggat tgaatatgag catacaaagt tcaattggag aagaggtcat ctatcggcta
    12661 ttaatgattc cagtcatttg gtggatgagt ggaaatatcc tcatctccat tattgtatct
    12721 tcctttttat gggcggtgat gcaccaagta actggatatg acccaaggtg gatacgttgg
    12781 ctgcatctat ttatattcgg ttgctttctg ggagttctct tcatcaaatt tggttttatt
    12841 tgtgtattag tagctcattt cattcataat ttagtactcg tctgtatgcc gctgtggcag
    12901 ttcaagcttc agaaacatat gcatcatgat cagccaaagc atacttcact ctaatgatta
    12961 ggagaagatt tgatgcaatt gatgcaagta caaaatttaa gcaaatgcta tcgaaatggt
    13021 gatggggttg aacatttgtc tttctcaatt caacgaggag aaatcgtggc gctattgggg
    13081 ccaaatggag ctggaaaaac aacgacaatt cgatgtttga caggtctcta taagccggat
    13141 aaaggagata tcctcattga gggttctcct ccaggagata taaatgttca aaaaaaagtc
    13201 gcgcttattc ctgatcagcc atatttgtat cccgctttaa ctgctgctga acatattcag
    13261 tttagggcaa gaggatatca tccaggtaaa aaagatgtaa aagaaagggt ttatcatgca
    13321 ttgaaggaag tgcacttgga ggagaaagca aaccaattgt gtggtcagct gtcaagaggc
    13381 caaaagcagc gggttgtcct ggcgggggcg attgttcaag acgctttgct gtatatatta
    13441 gacgaaccga ctgtgggcct tgatatccca tcaaaacagt ggctctctaa ctggttaaaa
    13501 actaaaaccg atcaagggtg ttcagcattt gtatcaactc atagtctaga gtttgttata
    13561 gagacagcag acagggtgat attaattaga gacggcaaac tcatgcagga tttgtatgtt
    13621 cctcaattcg aagaagaaca agcggaatgg agaaaagaag tgattcgtct tctaggggaa
    13681 tggtcagatg aataatatca tttctttttt atggcttcag tcaaaaaggc gttttgtaag
    13741 tcaaggtcag gaaaaaaaaa tgcctttttt gatcatgctc ctttttgttg gggccatcgg
    13801 atttcaagta agttttgttt ctagatctac gacatgggat atgagtattg ctggttgggt
    13861 acttacaggt gtttttatcc tttatacggc atttggactt ttttcaaatc gattaccaag
    13921 tcaaatggca gatattatat ggctttatgg cactgccaca tctttttcaa aagttgtgta
    13981 tagtgtttta tttttcagcg tcacttggaa ggcgttgctt tggatcatct cagccatatt
    14041 cggtgatgta ttaattgtgc ttctgtctgg tgatcatatc aatttattag gtcgatccat
    14101 aatttttgta gggctctttt ttatcgctga agtgtggttg atgtcggtct cttgtgccag
    14161 aacagtgaag aaaatgaaaa gggtatacgt tttagtcttt cttctaatgt taggcattta
    14221 ctccatatgt ctttatcact tcttctttct ccaacattca tctgggatat gggagagcat
    14281 tgcccgtttt attagtggcg ttggattagt gtttgataca ttgtcaccgt tgtatgtggt
    14341 tgtatttatt gggatcatta cagtctcttt tatgacaatt gcttttacga gccgtcaggt
    14401 agaaatgaag gaatcgttgg tgaaagaagc tgaattctgg gaggaatttc aagaacgtca
    14461 atttggttca ggtcaaatta tacagaaacc aaaaacgact tggtggggct tgcaaggtct
    14521 aaatggaatt tggtcttttc tgtggttgga actgttgctt tttaaaaaat atttattttt
    14581 tcatagcatt catacggtca tgctcagtgg cgtcttttat gtcgtcattt tcatgtatcc
    14641 agaatggttt tatcttcttt tctttcttat cgtctcggca gtcatgttaa gttcctatta
    14701 ttcaggaatt gtcagacatt ctcaatcagg cacccttcat ttattccccg gtgccctttg
    14761 gaaaaaagtc attattctag agctgacgaa tacagtctgg ttgtatattc tttactgtgt
    14821 ctctattact tttatggcag ttgggaattt agtttattgg tatatatatg gcttagggat
    14881 atatatatgg ttcatgacaa taaggctttt tgcttttacc catacaaacc gaaacgatcc
    14941 taggctttca ttgcctcaat actacaagtc attttttatg gcattaggcc tgagcggcat
    15001 ttgtttgtat gtcattcatt tattgactgc tgactggtat acattagtgg tggtcgtctg
    15061 tatagggagc ctaagttggt gcctgtttta tcgtttcaga tagtggttat gtagagttat
    15121 tgttttaaaa cgaggagagg ggctctttta tgaattcaaa tggtgataaa ttgtcgttat
    15181 ctgttcagaa tttagcgaat acaaatgaga tcacaattgt tcaagcgata ggtgagctaa
    15241 agaaatcggg aaaagatgca ataccagttt tggttgaggc cttaaaagag gaaggctctt
    15301 tgtgtaatat tgctgcagct gttttaggtg agtttgggga agacgcgagt gaagcagcgg
    15361 aggagctatc atgtttatta aaaagtcatg ccgaagatac aagaatggca gcggcgattt
    15421 cattaatgag aatcgggaag cccagtctgc cctttgtcat caaaatcgct aaagaaagtg
    15481 aagggcaatc gtgcttttgg gcatcttggt gtattgcatg gattgatccg tcttgcattg
    15541 aacctaagat gtataaatgt ctaaaatacg agcatgaaca tccttcagga atagttgctc
    15601 cgtttgcggc tgaagaggcg ttaggaaagc tgattgcttt tcagctgaaa gataaggagg
    15661 actgaaagga tgaaagatga acaaatgttg actgaatggc caagtcattt accatggttg
    15721 aatcaatcac agaatgattt tacatttcca agtgacacat atcttcttct ttatttttgg
    15781 tcaatgagct gtccaaactg tcaccaatta acagacaaag tccttcaaga tataaaggat
    15841 atgaatgtga aagtaatcgg agtacatgtc ccttatatag aagaagagaa atctatggag
    15901 gttgtcttga cgtatgctct tgatagggga ctagctattc cgattgtatt agaccaaaac
    15961 tatgagatcg tcacaacttg tcacgtacaa ggcatcccca gcttttgtct attaagtcaa
    16021 tacggtcaga tcattactaa aacgatggga gatgttggtt gggataagat gttaaaaaag
    16081 attgcaggct tgtgaaattt tccgtcttgt atgtgcgaca aacggttgaa tattatgatg
    16141 aaacggtcct tcctataagc aggaaggttt ttttatgaaa tattttttta ttagtaggta
    16201 aattcatcaa atgttctgct atgctccaaa tgtacacctt tccgtaaggg caaagtcaaa
    16261 tatgaaaata aaactgttcc aaagttaatc agaaatttat tttcatattg tatcctttcg
    16321 gtatcaagtg aaaggagcat catatgaaaa cattatggaa agtcctcaaa attgtttttg
    16381 tcagcttggc tgctttggtt ttgcttgtat ccgtctcggt atttatttat caccatttcc
    16441 agctaaataa ggaggcggca ctccttaaag aaaaaggcac attagtcgaa gttgatggta
    16501 aaaagatgaa tgtgtatcaa gagggaagcg ggaaggatac gtttgtgttt atgtccggtt
    16561 cggggattgc tgcgcctgct tatgaaatga aggggctgta cagcaagttt tcaaaagaaa
    16621 ataagattgc tgttgtagat cgggcaggtt atggatacag tgaagtgtct cacgatgaca
    16681 gagatattga tacggtattg gaacagacga ggaaagcgct tatgaaaagc ggaaataagc
    16741 ctccttatat tttaatgcct cattcgatat ccgggattga agcaatgtat tgggcacaga
    16801 aatatcctaa ggaaatcaag gccattattg cgatggatat tggattgccc cagcagtacg
    16861 tcacgtataa attgagcgga gttgaccgat tgaaagtgag agggttccac ttgttaacct
    16921 cgattggttt tcatcggttt atgccttccg ctgtatataa tcctgaggtg attcggcagt
    16981 cgtttttaac tgatgaagaa aaagaaatct ataaagccat taactttaag caatttttta
    17041 atgcagatat ggagcatgag cttttacagt cttaccaaaa cggcagcaaa tctgtgaatc
    17101 tgccggcacc aaaggagact cccgtcttga ttttagatgc ggtctctgac caaaatagac
    17161 attcaaagta tgctatacaa aaccgaaaag actatgaagc gtttgcggct caattcaata
    17221 ctgccgatat aaaggaactg aggggaacac acagtattta tttatatcag cctgatcaaa
    17281 tatataaact gtccatggag tttatgagaa aggttcgcta ggatgaaggg ttatcatatt
    17341 ttaatcgttg aagacgatgt gatgattggt gatttgctgc aaaagatttt gcagcgtgag
    17401 ggatatcgtg tgatttggaa aacagatgga gcggatgtgc tttcggtgat tcagaaggtg
    17461 gatttggtca ttatggatgt gatgctgccg ggtgaagacg ggtatcaaat gtctgcaaaa
    17521 atcaaagagc tggggctggg cattccggtt gtttttctct cggcccgcaa tgacatggac
    17581 agcaagcttc aaggtttgca gatcggcgag gattatatgg taaagccctt tgatccgaga
    17641 gagctgctat taagaatgcg gaatatgctt gagcatcatt atggcacctt tacgcaaatc
    17701 aaacatttgt atattgatgc agtaacgaaa aaagtgttca atgaaagcct gcatgatgag
    17761 gtattgttta ctgcgattga gcggaaaatt ttcttttatt tatatgaaaa tagagacagt
    17821 atcctgacaa aggaacattt ctttgaatat ctatggcagc tcgaagatag aaacccgaat
    17881 attgtcaatg tgcatattaa aaaaatcaga gctaaaatca atgatcaagc gggtgagatg
    17941 attgaaaata tatatggaga agggtatcgg ctgaataccg ttgtgaagaa atgaagctca
    18001 agacaaaata tcagttgtta ttgtttacgg ccgtcattag tgttccgatg ctattgctgg
    18061 cggtcagtgt tttgatgtct gtgatttatg acagcatgtt taaaacgatg aatcatggta
    18121 tgccctttca caggtcgttt gcgtacccgg caatgatcgt tgtatttttg atatcgctct
    18181 tattgttagc ttttttattt tcaaagtcga ttcattctct gttgcataaa atcaatctat
    18241 taaatcaaac cattcggcat ttggcgagtg atcaaagggt gcccgataaa attgaagtga
    18301 agcgtgctga tgaaatcggg gaactgatca agtcggtcaa tttgttaatt gaacggacga
    18361 catatcgtga actggagctg agacagcaag aggaaatcaa aaaggagctt ttgcaaaaac
    18421 tgcggcatga cattaataca cctttaacgg ctctcaggct gcagttattt tatttggaag
    18481 accaatgtca tggtcaggct gtattcgaat cattgtatca gcaaatcgaa tatatctcgg
    18541 aattaaccaa tgaattcaat ctatattccg ctgagacgct ggaaagctct tatattgtaa
    18601 atgaagaagt gcgtctaaac gagctattag aaacagcggt aaaaaagtgg gattatttat
    18661 acagtatgag tgggattgag ctgcactata agccggcaga tcaagatgtg atatggatga
    18721 gcaacgcgtt atggatgcaa aggctgtttg ataatatttt tcaaaatacg ttaaagcatt
    18781 caaaagctga aaagatgtaa gtcacgattg aacatggcga tgtttttatt cgtgatgacg
    18841 gtattggatt tgatcggaat gagagcagtg agggacttgg gttaaagatt attgaggata
    18901 catgcaggct gcttgcgatt acttatgagc tgcatacaaa tgataatgga acggagttct
    18961 tgttttcaaa agagtgaccc tgctgatgtt tttctttctc ctataaaatt tatataatag
    19021 ggagaaagaa atggggtgaa catcatatgt ttaaaaaaat catcaaaacg attaagtacc
    19081 tctcaagcag ttctagtgac cgatatcgca gacatcggca ttacagcagc agccggcgca
    19141 gacattatcg cagctacagc agcagctcgg gcaaaagaag acactacgac cgttatggcg
    19201 gcagtcatcg ttacaaacgc cggagctaca gcagcagtta atccaaaaaa agttcttgtt
    19261 ccgcttttgg gacaagggtt tttttatgtg accgattgaa tggcccggtt tagatcctcg
    19321 cgaatggaag cggtgtgctg atactcctca tcaatgccca ataatctttt cagcagcagg
    19381 gttacttcct ttgtcagtgt taattcctcc agccaagtgc cgtttttctt cttttttcct
    19441 ttatattgag agtacagcag gaataacagc gtttctccga gatcgaagaa gtcatcctgt
    19501 tttcgtacct ttatttcctc catttcttca ggagtcaatt gtttggcaag gccgaaatcg
    19561 aggaggcaga gcctgccgtc attgatgatg atattaggcg tcctgatgtc gctgtggaag
    19621 ataaggcgat catgcaggta ttctataatc tcaagcagct gcgaaatcag ttgtaacgcc
    19681 ataagctctg tgaacggctg ttttcgaaaa aataataatt cttctatatt ctctccctca
    19741 atgaactgca tgacataata agcctgtccg tctatgatga actcatctat gaagcccgga
    19801 atttgcgggt ggtgaatgct tttgagcagt tttatttcct gttggaatcg gactctctct
    19861 ttttcctttt tcgcttttgt cggccgaagc tgttttaaga cataaggtgt ttgagttagg
    19921 atatcggtgc acaaataaac caaaccgtag cctcccatac caaggcactc ttcgattttg
    19981 tattgatgat ttaagataac gccgttcttt agagggcggt caaaaagcag tttttttaga
    20041 agttttaatg ccatgtctgc acttcccttg gttgtactga ttatagttta ccttctagac
    20101 ggagaataaa aaagagccgg ataaccggct cggtataagt taaaactgct ttgtcacgtc
    20161 gtattcataa tctatttttg cttttacgtt gctcatcgtc gatctggctg tcgctaatgt
    20221 attatattta aaactccata cctttgccac actgagttga tctgacaaag agatatcata
    20281 agaccctgaa gtcgagctgt ttacaagagc acggcgccat tcgttgtttt cgttcgtcat
    20341 gatcaggtgg cgtgtatttc cctggcttgg tgtttgagtg gcggttgtct gaactctggt
    20401 tacaatggca tcacgcggta tcccggattg gtttgttaaa tcaaccttga tcacgctgga
    20461 gtcagaacct gatgggctaa ggcttgtatt tcctttattt tcagcaacgc cgctgaattg
    20521 gaatgttccg ctgcccgatt tgattcggtc ttcaattgaa agtgtaaaat acatgtttcc
    20581 ggtataggtg cctcgtgaca ctttcacata aaaggtatct gtcgtgtttt gggcgtctgc
    20641 atttgcataa ataaaagaag aaaacgtatt agggttaatg acttctgtcc cttgagaaac
    20701 aggtattcta ttcttatcat aaatttcaat tttcatccct gtatacgcgc tctggtatgt
    20761 actcctcacg tatacttttt ctcccttatt agccgtaaaa gtgaaatagg cttcatcttg
    20821 accagcttcc agtattgttg tatcgatatt tttatatttc caataaccga tcggcattgc
    20881 ggtatcaaat gaattgtttc ctgtgatagc agtgactccg acagctgatg ccgaatacgt
    20941 aaaggtagat aagacagaca gcataacagc gaatggaata agccattttt tcaccatgca
    21001 aacaacctcc ttttatttcc atcatacata ataatgattt aggtgtaaat aaatgttttt
    21061 tgaggttaat atatacatta tctttgccga taaaaaagaa taagagagaa tactcgggag
    21121 ggaattcaat gcgtctgaat cggcaattta tccgcactca gctgatggca cagaacatat
    21181 ggagcaagaa tgcgcctgcc aaacgggaga atgcgactga aaatccagcg gcagttctgg
    21241 aaaaggcata cagcaggctt aagtcacaat cttcaactgg gggaatcaat cagttcaatt
    21301 attctaaaac cagcgtgtcg ggaaacagcg ggacgttcag caaagtgtat caatcagcga
    21361 atgatcgaac agtgacagac acaggggaag aaacagtgat tcaatcccaa aacccctatg
    21421 aatctgagag tgatatcaga atcaaaatac tagatgaaaa atacagcagg atgaatgcga
    21481 ttaataaaac aaagtctgat ccattaggct atattaagga taagtaccaa aattcaaagt
    21541 ctccttattt cagaagtgat ctgtcagctg cagaaagaca ggccgcttac gataatgaaa
    21601 cagaatggtt attcaaaggg aaggcgcaaa actataacct tcaggatgct gtgtttcgga
    21661 atgtcacatt tcatggggaa gtggaagctg agaatgaaaa ggtgtatcag cggggacagg
    21721 ttaaccagca gctgcaagta ctgttgaatc gaaaccatat tcatattcca gaggggacag
    21781 agctgacgtt tacaatcaca ccgattgact atcaggtgcg tgtaagcggg acagacgatc
    21841 aggatctgat caagcaaatt gagcaagtgc tgcaatctgg agacaacagc aaagaactat
    21901 ttttgcacat catgaaaagc caaagcagtg attcagcaca attttccgaa gaggcctatc
    21961 aaaagtatca ggctgctcgt gagatgtatg aagttacagg ctaccatttg aaggatttag
    22021 aagtgattga tgggcggtac gtcacgcctg agggacgtga cttaatggat gtatataagg
    22081 aagagcttga aaaagatcca gtgcagaaac aaacggcttc ttatgctata tcttactatc
    22141 gttcagagct cagtaaaatc gcggaagccg ggtataatgc cattccggat ttcatcctat
    22201 caattgatta cagcaatgga tctctgagag atgtgggaca aagcaagagc tatgggaccg
    22261 gagataccgg gtggcttgaa gcattaaagc gtcaaacggg tgtgaattat taagtaagct
    22321 gttcatgtag aacagcttat tttttatgag aatctaaggg gtgtattaat ttcaatattc
    22381 aaataatttt attattttta tataaaagat tttaaaagaa gtgaacgatt caaaactctg
    22441 aacaaaggtg tttacctgaa aaaaacaatt gtattttcca gagaaattta ttatgatgaa
    22501 ataagtaatt taggagatta tataacaatt ttaagtttga attttctgat tgttatcgct
    22561 gattcatgtg aaggcaagca ggtctgctgt tttctcattt atgttaggag gaggaagagg
    22621 agtggcaaat aaagaattaa agaggggcct gggcgcgcgc catattcaga tgatcgcctt
    22681 gggcggtaca atcggtgttg gcttgtttat gggttctgcc agcacgattt catggactgg
    22741 cccatctgtc cttctggctt atgcaatatg cggaattttt atctttttta ttatgcgtgc
    22801 gatgggtgaa atgctgtatg tcgagccgag cacaggctct tttgcgacgt tcggccatca
    22861 atatattcat ccgatggcag gttatataac agcatggagc aactggttcc agtggattat
    22921 cgtcggcatg tcagaaatta tcgctgtcgg ttct
//
