LOCUS       NZ_FQTY01000024        21425 bp    DNA     linear   CON 07-APR-2024
DEFINITION  Tissierella praeacuta DSM 18095, whole genome shotgun sequence.
ACCESSION   NZ_FQTY01000024
VERSION     NZ_FQTY01000024.1
KEYWORDS    WGS; RefSeq.
SOURCE      Tissierella praeacuta DSM 18095
  ORGANISM  Tissierella praeacuta DSM 18095
            Bacteria; Bacillota; Tissierellia; Tissierellales; Tissierellaceae;
            Tissierella.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900128955.1-RS_2024_04_07
            Annotation Date                   :: 04/07/2024 13:22:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,187
            CDSs (total)                      :: 3,132
            Genes (coding)                    :: 3,083
            CDSs (with protein)               :: 3,083
            Genes (RNA)                       :: 55
            rRNAs                             :: 3, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 1, 4 (5S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 13 of 49
            Pseudo Genes (incomplete)         :: 34 of 49
            Pseudo Genes (internal stop)      :: 8 of 49
            Pseudo Genes (multiple problems)  :: 5 of 49
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:14:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4772
            Orig. end                         :: 26197
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FQTY01000024.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21425
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21425
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21425
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11572](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11572)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_binding    complement(394..592)
                     /bound_moiety="tRNA"
                     /db_xref="RFAM:RF00230"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00230"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="T-box leader; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
     gene            complement(641..1039)
                     /locus_tag="BUB33_RS14625"
                     /old_locus_tag="SAMN02745784_03015"
     CDS             complement(641..1039)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033749.1"
                     /locus_tag="BUB33_RS14625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03015"
                     /product="hemerythrin family protein"
                     /protein_id="WP_072977823.1"
                     /transl_table=11
                     /translation="MLWWTEELETGIESIDKQHKSIFDKASEIFNLGVNSNIKEVEKIF
                     IFLMGYANNHFYEEEILMMENSYKDFIEHRRQHNYFIEKIYRIYQNTIEGQVSEENLND
                     LKLLIIEWLANHINVEDKKYIKLMKSIQ"
     misc_feature    complement(1046..1055)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 14.7"
                     /tool="antismash"
     gene            complement(1059..2537)
                     /gene="hemZ"
                     /locus_tag="BUB33_RS14630"
                     /old_locus_tag="SAMN02745784_03016"
     CDS             complement(1059..2537)
                     /EC_number="1.3.98.3"
                     /GO_function="GO:0051989 - coproporphyrinogen dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006312018.1"
                     /locus_tag="BUB33_RS14630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03016"
                     /product="coproporphyrinogen dehydrogenase HemZ"
                     /protein_id="WP_072977825.1"
                     /sec_met_domain="PF04055 (E-value: 6.1e-23, bitscore: 72.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKLLLINHETRYELVELIRVFFPGQEVISIDTKNDYIGEGILIV
                     NSLYEENGIKFATTSLYINDVLVKQSTENIELIEIYGRSIDKYIRIGIKKSLYNTLISL
                     NEAKIPWGILTGIRPVKIVHELLDRNIDDNEIIRVLTEEYKLYIDKAKLILNIGKKQRK
                     YIEPLNKDKYSLYISIPFCPTRCLYCSFPALPIGRYENHIKEYISKLIYEINNISKMMK
                     GKNINTVYIGGGTPTAIPPTELEKVIHCIYNNFGQKDIKEFTVEAGRPDTITEDYLRML
                     NKNNIRRISINPQTMNDGTLKLIGRQHKTEDIIKTFKLAKEIGFDIINMDLIIGLPGED
                     ILHVKKTLEEIKRLDPENLTVHTLSVKRGSKFRDTIDKYSLQPQNILSTMLNETMEYSK
                     DMGLEPYYLYRQKQILGNFENVGYCKPKMECIYNIAMMEEKETIMAAGMGSVSKIFFPE
                     ENRIERVPNFKDLKEYVERIDELVENKKVKLEGS"
     gene            complement(2556..3176)
                     /locus_tag="BUB33_RS14635"
                     /old_locus_tag="SAMN02745784_03017"
     CDS             complement(2556..3176)
                     /codon_start=1
                     /gene_functions="resistance (resist) ClassB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005583290.1"
                     /locus_tag="BUB33_RS14635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03017"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_072977827.1"
                     /transl_table=11
                     /translation="MKIVRIPAGIYAANCYIIYSEVTRDAIVVDPGGDVDDILSSIREN
                     GLKIKYIVLTHGHADHIGGVKELKKVLSVPVMIHEDDREILVDGNKNLSTIMAMGTVEI
                     EPDILLKDGDIIEFGDEKAQVIHTPGHTQGGICIKIGDSIITGDTLFTGSIGRTDLLGG
                     DYDSIINSIKDKIMVYSDDIKVFPGHGAPSTIGRERTSNPFLR"
     gene            complement(3188..3637)
                     /gene="dtd"
                     /locus_tag="BUB33_RS14640"
                     /old_locus_tag="SAMN02745784_03018"
     CDS             complement(3188..3637)
                     /EC_number="3.1.1.96"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dtd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004824002.1"
                     /locus_tag="BUB33_RS14640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03018"
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="WP_072977830.1"
                     /transl_table=11
                     /translation="MRAVVQRVSEATVRVDNKVAGEIGKGLLVFLGIGEGDTEKDLEYL
                     VDKVLGLRIFQDENDKMNLSLLDINGEILVISQFTLYGDVRKGKRPSFTDSAHPDIAER
                     MYLEFIDKCKTKEIKTEKGIFGADMKVSLVNDGPVTILLDSKKLF"
     gene            complement(3650..5812)
                     /locus_tag="BUB33_RS14645"
                     /old_locus_tag="SAMN02745784_03019"
     CDS             complement(3650..5812)
                     /EC_number="2.7.6.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015970 - guanosine tetraphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005583287.1"
                     /locus_tag="BUB33_RS14645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03019"
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="WP_072977832.1"
                     /transl_table=11
                     /translation="MLENLLLKIEQYNSQADLSLIVKAYNFAQLAHEGQIRNSGEKFFI
                     HPFNVAIILADLNMDTDTIVAGLLHDVIEDTEITYENIVEEFGVEIANLVEGVTKLKKL
                     QYKTKQENQAENLRKMVLAMANDIRVIIVKLADRLHNMRTLEYMRDEKRKEKALETLEI
                     YAPLAHRLGISKIKWELEDLSLRYLDPDNYYDLVEKVSKRRQEREAYVKNIIETLSKKL
                     DEVKIKYDVSGRPKNFYSIYKKMVHQGKAFEQIFDLTAIRVIVDNIKDCYEVLGIVHNL
                     WKPLPGRFKDYIAMPKPNMYQSIHTTVIGMKGEIFEVQIRTWEMHRTAEYGIAAHWKYK
                     EGSTKSDSFDDKLTWLRQLLEWQSDLNDPKDFMETLKIDFFTDEVFVFSPKGDVINLPD
                     GSTPIDFAYRVHTEVGNKCVGAKVDGRIVPLNYKLKNGNIVEIITSTNSNGPSRDWIKI
                     VKSTQAKTKIRQWFKAKEKDLNIIRGKESLEKEVKRLGYKTSEILKDEWLKNIACKVSV
                     NSIDDLYASIGYGNITLNQVISKLKVQYNDYYKITDEKAFIESKIQQPSQGKISKPTQG
                     IKIKGIDNIKIRFSKCCNPVPGDEVVGYITRGRGVSVHRADCPNIIMSEDVERFIEVEW
                     DFQKKASYPAEIQIKASDRSGLLAEITQKITDSDLGVISLNARTSKDKIVFINVTLEIK
                     NIEELRDLMKKVKRIKNVMDVYRVTA"
     gene            complement(5899..7683)
                     /gene="recJ"
                     /locus_tag="BUB33_RS14650"
                     /old_locus_tag="SAMN02745784_03020"
     CDS             complement(5899..7683)
                     /GO_function="GO:0008297 - single-stranded DNA
                     exodeoxyribonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009222186.1"
                     /locus_tag="BUB33_RS14650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03020"
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="WP_072977835.1"
                     /transl_table=11
                     /translation="MEKWFIKNKGNDYKKIAKDFKISEFLSKLLVNRDITDYRLIDSFI
                     YPDLSKLHSPDFMKDLLKGASIIKEDIINKRKIRIVGDYDVDGVISIYLLYRGIKKCGG
                     NVDYVVPNRIDDGYGINIEIIKEAKIDNIDTIITCDNGIAAIEQIEFAKKLGLTVIVTD
                     HHDIPFILDEKGEKKYLYTDADAVINPKQEDCKYPFKGLCGAAVVFKLIQKLYSIFNLP
                     QEEIYYFLEYLAIATVCDVVDLVDENRIIVKKGLELLNKTKNIGLKALIKETGIEGKEI
                     GVYHLGFIIGPNINASGRLDSALKAIELLLSDDLDSADTLAKELRELNDERKEMTKEGV
                     EKIVKIIETSELKDDKVFVIYEPEIHESIAGIIAGRIKERYNKPTIVLTRGKDGVKGSG
                     RSIEGYNMFEELSQCKDLLSRFGGHPMAAGLSLEEDNIIKLRKSLNKNTILTDEDLIPK
                     VYIDMQIPLEYISFKLINEIKLLEPFGKGNTKPIFGEKNLKINRAFILGANRNVLKLIL
                     ENESRKTLEGIFFGDIEAFENTIENIYGKNELNKVYSGIDNNIKIDILYYPSINEYNGN
                     TNLQIIIQNYRVSRNVAY"
     gene            complement(7825..8691)
                     /gene="secF"
                     /locus_tag="BUB33_RS16455"
                     /old_locus_tag="SAMN02745784_03021"
     CDS             complement(7825..8691)
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014967884.1"
                     /locus_tag="BUB33_RS16455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03021"
                     /product="protein translocase subunit SecF"
                     /protein_id="WP_084725503.1"
                     /transl_table=11
                     /translation="MDIIKNRKIFAIFSLVIIIVGLLMFFTKGLNYGIDFTGGTLIQIN
                     AGKFIPVDEVREITDEYDKDVSVLHAGIEKDEIIIKSTLDLSNDTITSIVNKFIEKYNI
                     NENNFQSEKFGPLMGKEIREKAMLSTLIATVLMLGFITWRFEFNFGLAAIIALVHDIFI
                     MLAVYSILRIPVNSSFIVAILTILGYSINDTIVIFDRIRENVRLYPKESPENLINKSIK
                     QSLKRTINTSFTTLIAILMLYILGVEAIKVLALPLMIGVLAGTYSSMFIASPIWYELKN
                     RKIKTAK"
     gene            complement(8707..9990)
                     /gene="secD"
                     /locus_tag="BUB33_RS16460"
                     /old_locus_tag="SAMN02745784_03022"
     CDS             complement(8707..9990)
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006312036.1"
                     /locus_tag="BUB33_RS16460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03022"
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_084725505.1"
                     /transl_table=11
                     /translation="MKAKNTILFILVLAIVGGSTFLALNGAKIGKYEIPKAKDSIELGL
                     ELAGGVYVVLEAQTDAKGAELQKIMEQSKAIINERINGLGVSEPNISIEGGNRIRVELA
                     GINDPQKAIELIGKTAQLQFVDPKGNIVLTGKNVAGSEVQYHTDKLNQQEIVVSLELDK
                     EGTERFAEATGRLTLEPKREDRIIYIILDDQVISYPAVKGVAEGGTAITDGKAVITGGF
                     TLEEASQLATLIRAGALPVEMKELQTSVIGPTLGLEAYEKSIKAGAIALLIIMVFMMSI
                     YRIPGFIASIGLIIYTLITIFTMSSLGVKLTLPGIAGLILSIGMAVDANVIIFERIKEE
                     IKIGKSVRTAVDAGFKRALTSVIDSNITTLIAGTVLYYFGTGPIKGFGVTLIIGIVASM
                     ITSVIISKYLLKSIVSITGGKNSKLYGA"
     gene            complement(10001..11362)
                     /gene="scfB"
                     /locus_tag="BUB33_RS14660"
                     /old_locus_tag="SAMN02745784_03023"
     CDS             complement(10001..11362)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006312039.1"
                     /locus_tag="BUB33_RS14660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03023"
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_072977837.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 4.1e-24,
                     bitscore: 75.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 4.7e-79, bitscore:
                     256.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.8e-16, bitscore: 51.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.5e-16, bitscore: 51.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.9e-22, bitscore:
                     70.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.1e-08, bitscore: 25.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRASKMHKFHLNNKYIILDVNTGAVHVVDKIVYEIIDYYGEKSI
                     DEIKNIFKSTYGEKAVEDVYNEIDELVKEGLLFSEGIDISNFKYNEENIVKAMCLHVAH
                     DCNLKCNYCFASQGDFKGERSLMSLEVGKKALDYLVKHSGTRRNLEVDFFGGEPLMNFN
                     LVKELVQYGRSLEQEYNKNFRFTITTNGVLLDDEKIDYINENMSNVVLSLDGRKEVNDN
                     MRKTISGEGSYDIILPKFKKMVEKRGDKDYYIRGTFTSNNIDFSKDALDFYNNGFKKIS
                     IEPVVTSEEMDYALREEHLQLVLDEYEKFSKEYINIKKMDKDFYFFHFMIDLKQGPCII
                     KRAVGCGAGSEYMAVTPEGDLYPCHQFVGEEGFKLGTVFDGVENTSLREKFKKANVYNK
                     EECRECWARFYCSGGCHANSYHAHKDLSKAYKLGCEMEKKRIECAISILANLDD"
     aSDomain        complement(11060..11344)
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BUB33_RS14660_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="3.90E-24"
                     /identifier="RREFam024.1"
                     /label="BUB33_RS14660"
                     /locus_tag="BUB33_RS14660"
                     /protein_end="101"
                     /protein_start="6"
                     /score="75.7"
                     /tool="antismash"
                     /translation="MHKFHLNNKYIILDVNTGAVHVVDKIVYEIIDYYGEKSIDEIKNI
                     FKSTYGEKAVEDVYNEIDELVKEGLLFSEGIDISNFKYNEENIVKAMCLH"
     gene            complement(11432..11572)
                     /gene="scfA"
                     /locus_tag="BUB33_RS14665"
                     /old_locus_tag="SAMN02745784_03024"
     CDS             complement(11432..11572)
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014967888.1"
                     /locus_tag="BUB33_RS14665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03024"
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_072977839.1"
                     /sec_met_domain="TIGR03973 (E-value: 3.6e-26, bitscore:
                     81.8, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 9.6e-27, bitscore: 83.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYIKTISGSNLKDTIAKGGCGECQTSCQSACKTSCTVGNQKCEN
                     K"
     misc_feature    complement(11579..11594)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     gene            complement(11650..12027)
                     /locus_tag="BUB33_RS14670"
                     /old_locus_tag="SAMN02745784_03025"
     CDS             complement(11650..12027)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005583282.1"
                     /locus_tag="BUB33_RS14670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03025"
                     /product="TIGR04086 family membrane protein"
                     /protein_id="WP_072977841.1"
                     /transl_table=11
                     /translation="MKTKNLDRGIHLLRGLLLAYIITCILILFFSLLLTYSSLKENKMP
                     LMNTVIMMLSIIVGSIYVSKGIKEKGWINGGIVGIVYYSILIILNLIFLKSLKLDIFSI
                     SKLALACITGIIGGIIGINIS"
     gene            complement(12122..12442)
                     /gene="yajC"
                     /locus_tag="BUB33_RS14675"
                     /old_locus_tag="SAMN02745784_03026"
     CDS             complement(12122..12442)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="yajC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005583281.1"
                     /locus_tag="BUB33_RS14675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03026"
                     /product="preprotein translocase subunit YajC"
                     /protein_id="WP_072977844.1"
                     /transl_table=11
                     /translation="MPQQLQGLIIPIGFLVVFYIFAIRPQKKREQQVREMRDNLRVGDE
                     IITIGGINGKIIKVKEDFITIEVGSSRTKLDMARWSVGSVVNKNESKKSKDEEVDTKEE
                     DK"
     gene            complement(12498..13622)
                     /gene="tgt"
                     /locus_tag="BUB33_RS15910"
                     /old_locus_tag="SAMN02745784_03027"
     CDS             complement(12498..13622)
                     /EC_number="2.4.2.29"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008479 - tRNA-guanosine(34) queuine
                     transglycosylase activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tgt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) bTGT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004833006.1"
                     /locus_tag="BUB33_RS15910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03027"
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="WP_072977846.1"
                     /sec_met_domain="bTGT (E-value: 3.4e-203, bitscore: 665.3,
                     seeds: 1816, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIRFELLKEAKDCKARLGKLYTPHGVIETPIFMPVGTRATVKAM
                     TPEEVKGLGAQIILSNTYHLYLRPGHKLIEEAGGLHKFMNWDGPILTDSGGFQVFSLGD
                     LRKIKEEGVEFRSHIDGSKHFISPEKSIEIQNSLGSDIMMCFDECTPYPATYEYAKHSM
                     ERTTRWAKRCKDYHKNWDKQGLFGIVQGGMYKDLREQSAKELVELDFPGYAIGGLSVGE
                     PKELMCELLDFTTPLLPKDKPRYNMGVGTPDYLFESVIRGIDMADCVLPTRIARNGTAL
                     TSQGKIVIRNAKYAKDFTPLDPECDCYACTNYSRAYIRHLFNVDEILGARLTTIHNLYF
                     LIKLMENIRKAIKEDRILEYKDEFYKKYGYNDKN"
     gene            complement(13635..14660)
                     /gene="queA"
                     /locus_tag="BUB33_RS15915"
                     /old_locus_tag="SAMN02745784_03028"
     CDS             complement(13635..14660)
                     /EC_number="2.4.99.17"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="queA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004838766.1"
                     /locus_tag="BUB33_RS15915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03028"
                     /product="tRNA preQ1(34) S-adenosylmethionine
                     ribosyltransferase-isomerase QueA"
                     /protein_id="WP_072977849.1"
                     /transl_table=11
                     /translation="MKRENFSYFLPEKLIAQHPLKNREESRLLVLDKKTGKIEHKKFKD
                     IIDYLNKGDCLVLNDTKVIPARLFGNRVGKEESIEILLLKRMEDNLWETLVKPGKKARP
                     GHIIEFGGGVLKGEVLSIGEDGTRIIKFEYKGIFEEILDSLGEMPLPPYITEVLEDKDR
                     YQTVYSKHKGSAAAPTAGLHFTNELLNEIRDKGVNIAYITLHVGLGTFRPVKVDNILEH
                     HMHSEYYNIPEEAANIINKSRENGGKIISVGTTSTRTLETVSDENGKIIPKSGWTDIFI
                     YPGYRFKIIDRLITNFHLPESTLLMLVSALATQERILDAYKIAVEEEYRFFSFGDAMFI
                     K"
     gene            complement(14691..16058)
                     /locus_tag="BUB33_RS14690"
                     /old_locus_tag="SAMN02745784_03029"
     CDS             complement(14691..16058)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02669.1"
                     /locus_tag="BUB33_RS14690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03029"
                     /product="SpoIID/LytB domain-containing protein"
                     /protein_id="WP_072977851.1"
                     /transl_table=11
                     /translation="MKKNISKFLILMLLLALLPVKKSYAKNINNQYLNIRLTKPIKQKN
                     VVNFGSNNGFLLFSINNKDDVLLNIDDTNIKAVLSENGINLVNSREDILFTLPKDGSVL
                     ISSNTFNNSIITVEKDRYRDYIRLLSKNNEIYVINHVELENYLYGVVPAEMPSTFHMEA
                     LKAQAVASRSFAISNINKHSSEGFNLCDTTHCQVYSGVEYERPSTNLAVDETRDVFAYY
                     NGKVIEAIFHSTSSGFTEDSVNVWGGDFPYLKSVEDSFSLESPYSKWSFSINLNELNNN
                     LISSGIDIGNLQGMEIIEATSTGKVNKVKVIGTKGEKIINGTQFRNIVGASKFKSSWFD
                     IKSGNMSTSDNQVYIMDGAMLKPQTMDINKAYIIDGKNQNKVTRGSVSRAMGKDKVESL
                     GQFYPINSSEILIEGKGFGHGVGMSQFGAKKMAELGYDFEEILKYYYTGIDVLTNN"
     gene            complement(16086..17096)
                     /gene="ruvB"
                     /locus_tag="BUB33_RS14695"
                     /old_locus_tag="SAMN02745784_03030"
     CDS             complement(16086..17096)
                     /EC_number="3.6.4.12"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0009378 - four-way junction helicase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005583801.1"
                     /locus_tag="BUB33_RS14695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03030"
                     /product="Holliday junction branch migration DNA helicase
                     RuvB"
                     /protein_id="WP_072977854.1"
                     /transl_table=11
                     /translation="MENINDRIVAGSLRNEDLESELTLRPKWITEYIGQDKAKEKLNIF
                     IQAAKGRNESLDHVLLYGPPGLGKTTLANIIANEMGVNIRVTSGPAIERPGDLASILTN
                     LSEGDVLFIDEIHRINRTVEEILYPAMEDFALDIIIGKGPSARSVRLDLSKFTLIGATT
                     RAGLLTSPLRDRFGVMLNLELYDDESLKQIVIRSADILDIEIEDKGALEIARRSRGTPR
                     IANRLLKRVRDYAQVVEKGIITWEVARKGLEVLEIDELGLDSVDRKLILTLIENFNGGP
                     VGVDTLSAATGEERNTIEDVYEPYLLQIGFLNRTPRGRMVSKKAYEHFEIPYTED"
     gene            complement(17111..17710)
                     /gene="ruvA"
                     /locus_tag="BUB33_RS14700"
                     /old_locus_tag="SAMN02745784_03031"
     CDS             complement(17111..17710)
                     /EC_number="3.6.4.12"
                     /GO_component="GO:0009379 - Holliday junction helicase
                     complex [Evidence IEA]"
                     /GO_function="GO:0009378 - four-way junction helicase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006312056.1"
                     /locus_tag="BUB33_RS14700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03031"
                     /product="Holliday junction branch migration protein RuvA"
                     /protein_id="WP_084725507.1"
                     /transl_table=11
                     /translation="MNNLFEFIIGDIVAIREDYIVLQNNGIGYKIFTSTNTMIQIELGM
                     KNAMIFTYLNVREDGIFIYGFISEEELNMFKLLQMVSKIGPKIALGILSTLNSNQIKLA
                     IMRKDLDVLCKAPGIGKKTAERIILELKDRIDKDIIIEEDNISDLNYDNYMEAINGLMS
                     LGYTRIEVEKIIKTMDISNMSIEDIIRETLKRLSKH"
     gene            complement(17727..18221)
                     /gene="ruvC"
                     /locus_tag="BUB33_RS14705"
                     /old_locus_tag="SAMN02745784_03032"
     CDS             complement(17727..18221)
                     /EC_number="3.1.21.10"
                     /GO_function="GO:0008821 - crossover junction DNA
                     endonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="ruvC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005583805.1"
                     /locus_tag="BUB33_RS14705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03032"
                     /product="crossover junction endodeoxyribonuclease RuvC"
                     /protein_id="WP_072977859.1"
                     /transl_table=11
                     /translation="MIILGIDPGIAIVGYSIIECNGNKFKAIDYGCIRTDSDILFPDRI
                     KIIYNRLIEIIEKYKPEDLAVEELFFNKNVKTAIKVGQARGVEILAAVNKGLNIYEYTP
                     LQIKQSVVGYGRADKNQVQEMVRILLNLKEKPKPDDVADALAVAICHGSSIKFKEAFRM
                     K"
     gene            complement(18302..18895)
                     /locus_tag="BUB33_RS14710"
                     /old_locus_tag="SAMN02745784_03033"
     CDS             complement(18302..18895)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BUB33_RS14710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN02745784_03033"
                     /product="hypothetical protein"
                     /protein_id="WP_072977861.1"
                     /transl_table=11
                     /translation="MKKDKVLPVFFFSLTLFLVSFIFGYQLMSKRLNPKDISKIDIKEK
                     DILEHPEKEILGEGNRISPNTFIEERIHYMACNHVVTKTNLVEDNMVNMTREEFIEYIQ
                     ENYPDKKLISFSSSKITLGTTKNHLCENHYIVGEKDGLIAIFKVGENGERVLDNVLVDY
                     PISLLMDIDQEKIIDGIVVDNEDELSEILENFIS"
     gene            complement(18965..19597)
                     /locus_tag="BUB33_RS14715"
                     /old_locus_tag="SAMN02745784_03034"
     CDS             complement(18965..19597)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013962.4"
                     /locus_tag="BUB33_RS14715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03034"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_072977864.1"
                     /transl_table=11
                     /translation="MFIRNYMLPKEKLTTVELGESLGRALEKINEGNFLSLPVIDGKEF
                     KGILMKEAVYRNYLESGKCNKEEYLNNTKVEEIYNNNYESISADERIEKASYLLKELRT
                     PFLPVFDSNDKFVGILTHFAIFNAFSEIFGIDKGTRIVINMFDLPGQLARLTDVIRKEN
                     INIINFAIMDPKVLDLIQVILRVDTDDVDKLVDKIQSAGFKIGEVTK"
     gene            complement(19621..20355)
                     /locus_tag="BUB33_RS14720"
                     /old_locus_tag="SAMN02745784_03035"
     CDS             complement(19621..20355)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BUB33_RS14720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN02745784_03035"
                     /product="hypothetical protein"
                     /protein_id="WP_072977866.1"
                     /transl_table=11
                     /translation="MAIANNELSSIYDGLIYKFLYNNDISCIHILLNLYDLEENITNIC
                     PKYVSIHNLKKHISKFLKKRKGNYSISLNLGQLIHEDINRLELFIYLEGYKHGYFNNYW
                     VNILEEIAIKNTPIDKLYKSKYLYHFDNKIKQISDVKALIGGEIQKGEKQNKYLYDIIR
                     DYCHKLLRTKIFNLNEHLDKQLTIEYNSKPCNTKEEDNLLTLDELNSIYKEMVKIVLKD
                     GLKLYKEAYWYGLNDRVLKRYR"
     gene            complement(20529..20978)
                     /locus_tag="BUB33_RS14725"
                     /old_locus_tag="SAMN02745784_03036"
     CDS             complement(20529..20978)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014656.4"
                     /locus_tag="BUB33_RS14725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_03036"
                     /product="endolytic transglycosylase MltG"
                     /protein_id="WP_072977869.1"
                     /transl_table=11
                     /translation="MNKRIKLAYLTLGIGIGMIFTNILYSFNPNIKYLDLEDEAIIEKA
                     KELGMVNLKESIEVENIKEDPIEEKKEDEVIEPIIETEIIVESGSNLTRVAKNLYDANL
                     IKDVDEFVLFVKGKKLDKKIRTGRYKIKSNSSYDDIIEILTRRLN"
ORIGIN
        1 ataggcggag tttcagattc gtctaaaatc ttaagttcct ctactaatac ctctacttct
       61 ccagttggta tttctttatt aatagattgt ctaatcctta cttttcctct tactgccaat
      121 acaaattctg atctaacttt ctctgctttt tcaaatatct cactggatac tgtattatca
      181 aatactactt gagaaattcc agttgtatcc cttaaatcaa taaatataag tgaacctaga
      241 tttctctctc tttgtaccca ccccatcaac actacttctt gaccatcatg ctctggtctt
      301 aattctccac acataatagt tcttcttaaa tttcccattt tttctaccat tatattacct
      361 cctcaaaaaa atataaacct ctcatctctg atatccaggg acgagaggct atctcgcggt
      421 accaccctaa ttaggtattt cctcactcaa aaatttaacg catttctgcg aattaatctt
      481 atagattatc tactccaagg tgtcttcatt aaatattagt gtcagctttc cacctttcac
      541 tgactctcta taactaagta atttaactac tcttcctttt caatgtatta tatttatttt
      601 tattaattat agaatataaa ataactcatg tcaaggagta ttattgaata ctcttcatta
      661 atttaatata tttcttatct tcaacattta tatgattagc aagccattct attattaaca
      721 attttaaatc atttagattt tcttctgata cctgtccctc tattgtattt tgatatattc
      781 tataaatttt ctcgataaaa taattatgct gtcttctatg ttcaataaaa tctttataag
      841 aattttccat catcaatatt tcttcttcat aaaaatgatt gtttgcatac cccattaaaa
      901 atataaatat cttctcaact tctttaatat tagaattaac tcctaagttg aaaatctcac
      961 ttgccttatc aaatatactt ttatgctgct tatctatgga ctctatgcct gtttccaatt
     1021 cttctgtcca ccataacata atataagccc ccttcctatt aactaccttc taacttaact
     1081 tttttgtttt caactaattc atctattctt tcaacatatt cctttaaatc tttaaaatta
     1141 ggaactcttt ctattcgatt ttcttctgga aagaaaattt tagatactga ccccattcct
     1201 gctgccatta tagtttcttt ttcttccatc atagcaatat tatatataca ttccattttt
     1261 ggtttgcaat atcctacatt ctcaaaattt ccaagtatct gtttttgtct ataaagataa
     1321 taaggttcta atcccatatc ttttgaatat tccatagttt catttaacat tgtacttaaa
     1381 atattctgag gttgtaatga atatttatct atagtatctc taaattttga tcctcttttt
     1441 actgaaagtg tatgaacagt taggttctct ggatctaatc ttttaatttc ttctaatgtt
     1501 tttttaacat gaagaatatc ttccccagga agtcctataa ttaaatccat atttattata
     1561 tcaaatccaa tttccttagc tagtttaaaa gttttaataa tatcttctgt tttatgctgt
     1621 ctacctatta atttcaaagt accatcattc atggtttgcg ggttgatact tatccttctt
     1681 atattatttt tatttaacat tcttaaataa tcttctgtaa tggtatctgg tctgccggct
     1741 tctactgtaa attcttttat atctttttgt ccaaaattat tgtaaataca atgaattact
     1801 ttttcaagtt ctgtcggtgg aattgcagtg ggtgtacctc cacctatata tactgtattt
     1861 atatttttgc ctttcatcat cttagatata ttattgattt catatattaa ttttgaaata
     1921 tattctttaa tatgattttc atatctacct ataggtaagg ctggaaacga acagtataaa
     1981 catctagtag gacaaaaagg tatacttatg tataaactat acttatcctt gtttaagggc
     2041 tcaatatact ttctttgctt ctttccaata tttaatatca acttagcctt atcaatatat
     2101 agtttatatt cttctgttaa aactctaatt atctcattgt catctatatt tctatccaat
     2161 aactcatgaa caattttaac tggtcttata cctgttaaaa ttccccatgg tattttagct
     2221 tcatttagag aaatcaacgt attatataag gactttttaa tcccaattct tatatatttg
     2281 tctatggatc ttccatatat ttctataagc tcaatatttt ccgttgattg tttaactaaa
     2341 acatcattta tatataggct tgtagtggca aacttaattc cattctcctc atataaagaa
     2401 ttaactataa gaattccctc acctatatag tcgttttttg tatcaataga tataacctct
     2461 tgacctggga aaaaaactct aattaattca actaattcat atctagtttc gtgatttatt
     2521 aacaatagct ttatcacata atcaccttat ttatcttaac gtaaaaatgg atttgaagtc
     2581 ctctctctac ctattgtaga tggagctcca tgtcctggaa agactttaat atcatctgaa
     2641 taaaccatta ttttatcttt tattgagttt attatagagt cataatctcc tcctaataaa
     2701 tctgttcttc ctatagaacc tgtaaataga gtatctcccg ttattatact atctcctatt
     2761 tttatacata tacctccttg agtatgtcca ggagtatgaa taacttgagc tttttcatca
     2821 ccaaattcta taatatcccc atctttcaaa aggatatctg gttctatttc cactgttccc
     2881 atagccatta ttgtagaaag gtttttattt ccatcaacta gaatttctct atcatcttca
     2941 tgtatcatca ctggaacaga taaaaccttc ttcaattctt ttactcctcc tatatgatct
     3001 gcatgaccat gagtaagcac tatatattta attttaagtc cattttctct tattgatgaa
     3061 agtatatcat ccacatctcc acctggatct acaactatag cgtcccttgt aacttcagaa
     3121 tatataatat aacaattggc tgcatatatg cctgctggta ttcttactat tttcaaattt
     3181 atacctccta aaataatttt ttactatcta ataatatggt cacaggacca tcatttacaa
     3241 ggcttacttt catatcagca ccaaaaatgc ctttttctgt ttttatttcc ttagtcttac
     3301 atttatctat aaattctaga tacattctct cggctatatc aggatgtgct gaatcagtaa
     3361 aactaggtct tttacctttt cttacatctc cataaagagt gaattgagaa ataactaata
     3421 tttctccatt aatatctaat aaagataagt tcattttatc attctcatct tgaaatatac
     3481 gaagtcctaa aaccttatct actaaatatt ctaagtcctt ttctgtatct ccttcaccta
     3541 tgccaagaaa tactaataat ccctttccta tttcaccagc tactttatta tctactctaa
     3601 ctgtagcttc tgaaactctt tgtacaactg ctctcatcta tatctctcct taagctgtaa
     3661 ctctatatac atccattaca ttttttattc tttttacctt tttcattaaa tcccttaact
     3721 cttcaatatt tttaatctca agggtcacat ttataaatac tattttatcc ttggatgttc
     3781 tagcgtttaa tgatattact cctaaatcag aatctgttat tttttgagta atctctgcca
     3841 aaagtcctga tctatctgat gcctttatct gtatttcagc aggatatgac gctttctttt
     3901 gaaaatccca ttctacttct ataaacctct ccacatcttc tgacattatt atatttggac
     3961 aatctgccct atgaactgaa actccccttc ccctagttat ataccctact acttcatctc
     4021 ctggaactgg gttacaacat ttggaaaatc ttattttaat attatctata ccttttatct
     4081 taataccttg agtaggttta cttatcttcc cttgactagg ttgctgtatt ttactttcta
     4141 taaaagcttt ttcatctgtt attttataat aatcattata ttgtactttt aattttgaaa
     4201 taacttgatt taatgttata ttaccataac caatagacgc atacaaatca tcaatagaat
     4261 ttacgctaac tttacaagct atgtttttca accattcatc ttttaaaatt tcagatgttt
     4321 tatatcctaa tcttttaact tctttttcta atgattcttt tcctcttatt atatttaaat
     4381 ctttttcctt agccttaaac cattgtctaa ttttagtctt tgcctgagta ctttttacta
     4441 ttttaatcca atctctactg ggcccattac tgtttgtaga tgtaattatt tcaacaatat
     4501 ttccattctt tagcttataa tttaaaggaa caattcttcc atctacttta gcccctacac
     4561 atttatttcc tacttcagta tgaaccctat aagcaaaatc aataggcgta gaaccatcag
     4621 gaaggtttat tacatctccc tttggagaaa atacaaatac ttcatctgta aaaaagtcta
     4681 tctttaatgt ctccataaag tccttagggt catttaaatc agactgccat tcgagtaatt
     4741 gtctcaacca tgttagttta tcatcaaagc tatcagattt tgtacttcct tctttatatt
     4801 tccaatgggc agctattcca tattctgctg ttctatgcat ctcccaagta cgtatttgaa
     4861 cctcaaatat ttctcccttc ataccaatta ctgtagtatg aatggattga tacatattag
     4921 gtttaggcat ggctatatag tccttgaatc ttcctggtaa aggcttccat aggttatgaa
     4981 ctataccaag tacttcatag caatctttaa tattatctac tataactctt atggcagtta
     5041 aatcaaatat ttgctcaaaa gcttttcctt gatgaaccat ttttttatat atactataaa
     5101 aattctttgg tctaccacta acatcatatt ttattttaac ttcatctagt tttttactta
     5161 aagtttctat tatgtttttt acatatgctt ccctttcttg tcttctctta gaaaccttct
     5221 caactaaatc atagtaatta tcaggatcaa gatatcttaa agataaatct tctagctccc
     5281 attttatttt agaaattccc aatctatgtg ctaagggagc ataaatctct agagtttcta
     5341 gagccttttc ttttctcttt tcatctctca tatattctaa tgtcctcata ttatgaagtc
     5401 tatcagccag tttaactata ataactctta tatcatttgc catagctaaa accatttttc
     5461 tcaaattttc tgcttgattt tcctgcttag tcttatattg aagtttcttt aatttcgtta
     5521 ctccttctac taaattggct atttcaactc cgaattcttc tacaatattc tcataggtta
     5581 tttctgtatc ttctataaca tcatgaagta gacctgctac tatggtatcc gtgtccatat
     5641 ttaaatctgc taatataatg gcaacattga aggggtgaat aaaaaacttt tcacctgaat
     5701 tccttatctg tccttcatga gctagttgag cgaaattata tgcctttact ataaggctta
     5761 gatctgcttg tgaattatat tgttctattt ttaatagtaa gttctctaac atttgattca
     5821 ccctcttcat attaatgaat gtgtctataa gtttgattat ttataattac ccattatcaa
     5881 ttgcttataa caaataggtt aatatgccac atttcttgat accctataat tttgaattat
     5941 aatttgcaaa ttagtattac cattatattc attaattgaa ggatagtata gaatatcaat
     6001 ttttatatta ttatctattc cactatagac cttattaagt tcattttttc cataaatatt
     6061 ttctattgta ttttcaaagg cttcaatatc tccaaaaaat attccttcca atgtttttct
     6121 gctttcattt tccaatatta gctttaaaac atttctattt gcacctagta taaaagcccg
     6181 attaattttt agattttttt caccaaatat aggcttagta ttcccttttc caaatggttc
     6241 taaaagtttt atttcattaa ttaacttaaa gcttatatat tctaaaggaa tttgcatatc
     6301 tatatatact ttaggtatta aatcttcatc tgttaatatt gtatttttat ttaaagattt
     6361 tcgtagttta attatattat cctcttctag agacaaacct gctgccatag gatgtccacc
     6421 aaacctcgat aataagtcct tacattgtga taattcttca aacatattat acccttctat
     6481 agatctgcca gatcctttta ctccatcctt ccctcgagtt aatactattg taggcttatt
     6541 atatctttcc ttaattcttc ctgctatgat tcctgcaata ctttcatgta tctctggttc
     6601 atagattaca aatactttat catcttttaa ttccgaagtt tcaataattt ttactatttt
     6661 ttctactcct tctttagtca tttcttttct ctcatcattt aactctcgaa gttcttttgc
     6721 caaagtatct gcactatcta aatcatctga taaaagtaat tctatagctt ttaaagctga
     6781 atccagtctt ccagaagcat taatatttgg tccaataata aaccctaaat gatatactcc
     6841 aatttcctta ccttctatac ctgtttcttt tatcaaagct tttaaaccaa tatttttagt
     6901 cttatttaaa agctctaagc ccttctttac tataattcta ttttcatcaa ctaaatctac
     6961 tacatcacag actgttgcaa tagcaagata ttctaaaaaa taataaatct cttcttgtgg
     7021 caaattaaat atagagtata atttttgtat taatttgaat actactgctg ctccacaaag
     7081 acctttaaag ggatatttac aatcttcttg ttttggattt attactgcat ctgcatcagt
     7141 atataaatat tttttttccc ccttttcatc taatataaaa ggtatatcat gatgatctgt
     7201 aactattaca gttagtccaa gtttttttgc aaactctatt tgctctattg ctgctatacc
     7261 attatcgcaa gttattatag tatctatatt atctattttt gcttctttaa taatttcaat
     7321 atttatacca tagccatcat caattctatt tggtacaaca taatctacat tacctccaca
     7381 ttttttaatc cctctatata ataaataaat tgaaattact ccgtctacat cataatctcc
     7441 aactattctt atttttctct tgttaataat atcctcttta ataatagatg caccttttaa
     7501 taaatctttc ataaaatctg gactatgtaa tttacttaaa tctggatata taaaactatc
     7561 tattaatcta taatcagtta tatctctatt aactaaaagt ttagataaaa attcagatat
     7621 tttaaaatcc tttgcaattt ttttataatc atttcctttg ttttttataa accacttctc
     7681 caattacttc actccaatag aaataaaatt tagatacgct aattagtatc taaattttat
     7741 cattttatta catttaattc tagttattct tatatatttc ttattttttg acaaaaactt
     7801 cttatgatat aaaataaaaa ctgcctattt agcagttttt atttttctat ttttaagttc
     7861 gtaccaaatt ggagatgcaa taaacattga tgaataagta ccagccaaaa cacctatcat
     7921 aagtggtaat gcaagtacct taatagcttc aacccctaat atatataaca taagaattgc
     7981 aattaaagta gtaaaagatg tgtttattgt tctctttaaa gattgcttta tactcttatt
     8041 tattaaattt tctggtgatt cctttggata taatcttaca ttttctctta ttctatcaaa
     8101 aattactatt gtatcattta tagaatatcc taaaatagtt aaaattgcaa caataaaaga
     8161 actatttact ggaattctaa gaatagaata aacagctagc ataatgaata tatcatgcac
     8221 taaagcaatt atagctgcta atccaaagtt gaattcaaac ctccatgtta taaatccaag
     8281 cattaataca gttgctatta atgtggataa catagctttt tcccttattt cttttcccat
     8341 caaaggacca aatttttcag attgaaaatt attttcattt atattatatt tttctataaa
     8401 tttatttact atacttgtga ttgtatcatt tgaaaggtct aaggtacttt ttattattat
     8461 ttcatctttt tctatacctg catgtaaaac acttacatct ttatcatatt catctgttat
     8521 ttctctaact tcatctactg gtataaattt tcctgcattt atctgaatta atgtaccacc
     8581 agtaaaatca attccatagt ttaaaccctt agtaaaaaac ataagaagtc ccactatgat
     8641 tataactaat gaaaatattg caaatatctt tctattttta ataatatcca ttttttcacc
     8701 cctctattaa gctccataaa gcttgctatt cttgccacct gtaattgata ctattgattt
     8761 taacaaatat tttgaaataa taactgatgt tatcatagaa gcaactatac ctattattaa
     8821 ggttacacca aatcccttaa taggaccagt accaaaataa tataatacag ttccagctat
     8881 taaagtggtt atattagagt ctattacaga tgtaagtgct ctcttaaatc ctgcatctac
     8941 agcagttcta acactcttac ctatttttat ttcttctttg attctttcaa agattataac
     9001 attggcatct actgccatac ctatagacag tattaaacct gctatgcctg gaagtgttaa
     9061 tttaacgcct aaggatgaca tagtaaatat agttatcaat gtatatataa taagtccaat
     9121 agaagcaata aagccaggta ttctatatat actcatcata aaaaccataa ttataagaag
     9181 tgcaattgct cctgctttta tacttttttc atatgcttct aatcctaaag ttggtccaat
     9241 aacagatgtt tgtaattcct tcatttctac tggtaaagca cctgctctaa ttagagttgc
     9301 caattgacta gcttcttcta aagtaaaccc tcctgttata acagccttac catctgtaat
     9361 tgctgttcca ccttctgcta cacctttcac tgctggatat gatattacct gatcatctaa
     9421 aattatataa ataattctat cttctctctt tggttctaat gtaagtcttc cagtagcttc
     9481 agcaaatctt tcagtacctt ccttatccaa ctctagactt acaacaattt cctgttgatt
     9541 taatttgtct gtatgatatt gaacttctga ccctgcaaca ttttttcctg tcaatacaat
     9601 atttcctttt ggatcaacaa attgtaattg tgctgtctta cctattagtt caatggcctt
     9661 ttgtggatca tttatacctg ctaactcaac tcttatccta ttaccacctt caattgaaat
     9721 attaggttct gatacaccaa gaccatttat cctctcattg ataatagcct ttgattgctc
     9781 cataattttt tgaagttcag cacccttggc atcagtttga gcttctagca ctacataaac
     9841 tcctccagcc aattccaatc ctaattcaat tgaatccttt gcttttggaa tctcatattt
     9901 gccaatttta gcaccattta atgctaaaaa tgtgctacct cctactatag ctaatactaa
     9961 tataaataat atagtgtttt tagctttcat cttacccctc ctaatcatct aagtttgcca
    10021 atatagatat ggcacattct attcttttct tttccatctc acagcctaat ttatatgctt
    10081 tactaagatc tttatgagca tggtatgagt ttgcatggca tcctccacta cagtaaaatc
    10141 ttgcccagca ttctctacat tcttccttgt tgtatacatt agctttctta aacttttctc
    10201 ttaaacttgt attttcaact ccatcaaaaa cagtacctag tttaaaccct tcttccccta
    10261 caaattggtg acaaggatat aaatctcctt caggagtaac tgccatatat tctgaccctg
    10321 ccccacaacc aacagctcgc ttaattatac agggtccctg ctttaaatct atcataaaat
    10381 gaaaaaaata aaaatctttg tccatctttt ttatattaat atattcctta gaaaattttt
    10441 catattcatc taaaactaat tgtagatgtt cttctcttaa agcgtaatcc atttcctctg
    10501 aagtcactac tggttctatg gaaatctttt taaatccatt attataaaaa tctaatgcat
    10561 ctttggaaaa atcaatatta ttgctagtaa aggtacctct gatatagtaa tccttatctc
    10621 ctcttttttc caccattttt ttaaacttag gtagaatgat atcatagcta ccttccccag
    10681 agattgtctt tctcatatta tcattaactt cttttcttcc atctaaacta agaacaacat
    10741 ttgacatgtt ttcattgata taatcaatct tttcatcatc aagtaaaact ccatttgtag
    10801 taatagtaaa tctaaagttc ttattgtact cttgttctaa acttcttcca tattgtacca
    10861 gttccttaac taagttaaaa ttcataaggg gttctccacc aaaaaagtcc acctctagat
    10921 ttcttctagt accagaatgt ttaacaagat agtccaatgc cttttttcca acttctaaag
    10981 acattaatga cctttctcct ttaaaatctc cttgggatgc aaaacaatag ttgcatttta
    11041 aattgcagtc atgtgccacg tgtaaacaca ttgctttaac aatattttcc tcattatatt
    11101 taaaattaga aatatctatc ccctcagaaa ataaaagccc ctctttaact aattcatcta
    11161 tttcattata aacatcttca actgcttttt caccataggt acttttaaat atattcttta
    11221 tttcatctat ggacttttct ccataataat ctattatttc atatacaatt ttatcaacta
    11281 catgtactgc accagtattt acatctaaga taatatactt attatttaaa tgaaacttat
    11341 gcatctttga tgccctattc attaaacttc ctcccaatta acaattttat acaaataaaa
    11401 agtagtggat aaaccaccac cctttacttt tttatttatt ttcgcatttt tgatttccta
    11461 cagtacagga tgttttacaa gctgattggc atgaagtttg acattctcca caaccacctt
    11521 tagctatagt atctttcaaa ttgctgccag atattgtctt tatatatttc attttaaatc
    11581 cccccttggc gtctattttc tgctatttat tatatcatat tcttttttga atttaaagct
    11641 ttttttcttt taagatatgt ttatcccaat aatgccacct attattccag taatacaggc
    11701 tagtgctaat tttgaaattg aaaatatatc taattttaaa gattttaaga atataagatt
    11761 aagtataatt aatattgaat aatatactat tcctactatt cccccattaa tccagccttt
    11821 ttccttaatc cccttggaca cataaatact gcctactatt atactcagca tcataattac
    11881 tgtattcatt aaaggcattt tattttcttt aagtgatgaa taggttaata gtagtgaaaa
    11941 aaataatatt agaatacaag taataatata ggctaaaagc aaccccctta ataaatgaat
    12001 acctctgtct aaattctttg ttttcatata tctccctcct tatccttatt ttaatttatt
    12061 taaggaaagt gatatttatt acataaaaaa agcttcctta ttaaattagg aagctttttt
    12121 tctatttatc ctcttcttta gtatctactt cttcatcttt agattttttt gattcatttt
    12181 tattaactac tgaaccaact gaccatctag ccatatctaa tttagttcta gaagaaccta
    12241 cttctatggt tataaagtct tcttttactt ttataatctt cccattaatc ccaccaatgg
    12301 taattatttc atcaccaact cttagattat ctctcatttc tcttacttgt tgttctcttt
    12361 tcttttgtgg tctaatggca aaaatataaa atacgactaa aaatcctata ggtattatta
    12421 gtccttgtaa ctgttgtggc atgtataaac ccctcccttt ctataatcta ttatacagta
    12481 ttttttaaat aattcatcta atttttatca ttataaccat attttttata aaactcatct
    12541 ttatattcaa gaattctatc ttcttttatg gcttttctaa tgttttccat taattttatt
    12601 aaaaaatata aattatgaat tgtagtaagc cttgctccta aaatttcatc tacattaaat
    12661 aaatgtctaa tatatgccct tgaataattt gtacaagcat aacaatcaca ttctggatct
    12721 aatggagtaa aatccttagc atattttgca tttcttatga ctatttttcc ttgtgatgta
    12781 agagctgtcc cattccttgc aattctagta ggaagtacac aatctgccat atctattcct
    12841 ctaattaccg attcaaataa atagtctgga gttccaactc ccatattata cctaggtttg
    12901 tctttaggta ataaaggtgt agtaaaatcc aaaagttcac acattaattc cttaggttct
    12961 cctacactaa gtccacctat tgcatagcct ggaaagtcta actctaccaa ttccttggca
    13021 ctctgttctc ttaaatcttt atacattcct ccttgaacta ttccaaataa tccttgttta
    13081 tcccaatttt tatgataatc tttacatctt ttagcccatc tagtagttct ttccatagaa
    13141 tgttttgcat actcataggt agctggataa ggagtacatt catcaaaaca catcataata
    13201 tcggatccca aggaattttg aatttctata gatttttctg gacttatgaa atgtttcgaa
    13261 ccatcaatat gggatctgaa ttctactcct tcctctttta ttttccttaa atctcccaga
    13321 ctaaaaactt gaaagcctcc actatctgtt aaaataggtc catcccaatt cataaattta
    13381 tgtagtcctc ctgcttcctc tataagttta tgacctggtc ttaaatataa gtgataagta
    13441 ttacttaaaa ttatttgggc acctaaacct ttaacttcct ctggtgtcat agctttaact
    13501 gtagctctag ttcctacagg cataaatatt ggcgtttcta taactccatg aggagtatat
    13561 aattttccaa gtcttgcctt gcaatctttt gcttctttta ataattcaaa tcttattgcc
    13621 ataattacct cctgttattt tataaacatg gcatcgccaa aactaaaaaa tctatattct
    13681 tcttccactg ctattttata tgcatctaat attctttctt gggtagctaa tgcactaacc
    13741 aacatgagta aagttgattc tggcaaatga aagtttgtaa tcaatctatc tataatttta
    13801 aatctatatc caggataaat aaatatgtca gtccagcctg attttggtat gatttttcca
    13861 ttttcatcag atacagtttc caaggttcta gtagatgtag ttcctacaga tattattttg
    13921 ccaccatttt ctctggattt attaattata tttgctgctt cctctggtat attataatat
    13981 tcggaatgca tatgatgctc taagatattg tctactttaa caggtctaaa ggttccaagc
    14041 cctacatgta aggttatata ggctatatta acacctttat ctctaatttc atttaatagt
    14101 tcattagtaa agtgaagacc cgctgttggt gcagcagctg aacctttatg ctttgagtaa
    14161 acagtttgat acctatcttt gtcttctagt acctctgtaa tatatggagg caatggcatc
    14221 tcacctaaac tatctaaaat ctcctcaaat attcctttat attcaaattt tattattcta
    14281 gtgccatctt ctcctattga taaaacttcc ccctttaaaa ctccgccgcc aaattctatt
    14341 atatgcccag gtctagcctt cttcccaggt tttactaaag tttcccataa attatcttcc
    14401 attcttttaa gaagcaaaat ttctatactt tcctcttttc ctactctatt tccaaagagt
    14461 ctagcaggta ttacttttgt atcatttaaa actaaacaat ctcctttatt taaataatca
    14521 ataatatcct taaatttttt atgctctatt ttaccagttt ttttatccaa tactaacaac
    14581 ctagattctt ctctgttttt taaagggtgt tgagctatta gcttctctgg taaaaaataa
    14641 ctaaaattct ctcttttcat tagaccatcc ttctctatta taataattga ttaattattt
    14701 gttagcacat ctattccagt ataatagtat ttaagtatct cctcaaagtc atatcctagc
    14761 tctgccattt tctttgctcc aaattgactc atacctactc catgaccaaa tccttttcct
    14821 tctattaata tctcagaaga atttatggga taaaactgtc ctaaggattc taccttatct
    14881 ttccccattg ccctacttac acttccccta gttaccttat tttgattctt tccatcaatt
    14941 atataggctt tattaatgtc catagtttgg ggcttaagca tagctccatc cataatataa
    15001 acttgattat cagatgtact catattacca ctttttatat caaaccaaga acttttaaac
    15061 tttgaagctc caactatatt cctaaattga gtaccattta taattttttc tcccttagtt
    15121 ccaatgacct ttactttatt tacttttcct gttgaagtag cttcaataat ctccattcct
    15181 tgtaaatttc ctatatctat tccagatgaa attagattat tatttaattc attaagattt
    15241 atactaaaac tccacttact ataaggtgac tctaatgaga aactgtcctc tacagatttt
    15301 aaatagggga aatctcctcc ccatacattt acactatcct cagtaaagcc actacttgtt
    15361 gaatgaaata ttgcctctat tacctttcca ttataatacg caaatacatc tctagtttca
    15421 tctacagcca aattagttga aggtctttca tattcaactc cagaatatac ttgacaatga
    15481 gtagtatcac ataagttaaa tccttcagaa gaatgtttat ttatattaga aattgcaaaa
    15541 ctcctagagg ccactgcctg tgcctttaat gcctccatat ggaaggtaga tggcatttca
    15601 gcaggaacta ctccatataa atagttctca agttccacat gattaataac ataaatttcg
    15661 ttatttttac tcaataatct aatataatcc ctatatctat ctttttcaac tgtaattatt
    15721 gaattattaa aagtatttga tgaaattaaa acactaccat cttttggtaa agtaaataga
    15781 atatcttctc gagaattaac caagtttata ccattctcac tcaatacagc ttttatattt
    15841 gtatcatcta tatttaataa aacatcatcc ttattgttaa tagaaaataa taaaaatcca
    15901 ttattacttc caaagttaac aacatttttc tgttttattg gttttgttaa cctaatattt
    15961 agatactgat tattaatatt tttagcataa gattttttaa caggcaataa agctaatagt
    16021 aacattaaaa ttaaaaattt agatatattc tttttcatat atcctttctc cccctaatta
    16081 tatttttaat cttcagtata tggaatttca aaatgttcat atgccttttt agaaaccatt
    16141 cttcctctag gagttctatt taaaaaacct atttgtaaaa gatatggttc atatacatct
    16201 tctattgtat ttctttcttc tcctgttgct gcagacagag tatctacacc aacaggtcct
    16261 ccattgaagt tttctattaa agtaagaatt aatttcctat ctacactgtc caatcctaat
    16321 tcatcgattt caagcacctc taaacctttt cttgccacct cccaagtaat tatacctttt
    16381 tctacaacct gtgcatagtc cctgactctt ttaagtaatc tatttgcgat tctaggcgtt
    16441 cccctagatc ttcttgctat ttctaaagct cctttatctt caatttctat atctaatata
    16501 tcagcagatc taattactat ctgtttcaaa ctttcatcgt catataactc caagttcaac
    16561 attactccaa atctatctct aaggggtgat gttagtagcc ctgctctagt ggttgcacca
    16621 ataagtgtaa atttggataa atcaagcctt acggatctag cagaaggccc ttttccaatt
    16681 attatatcca atgcgaaatc ttccattgct ggatataata tttcttccac agttctgttg
    16741 attctatgta tctcatcaat aaacaaaaca tctccctctg aaagattagt taaaatacta
    16801 gccaaatccc caggtctttc aatggcaggt cctgatgtaa ctcttatatt aacacccatt
    16861 tcatttgcaa taatatttgc tagggtggtt ttcccaagtc caggtggccc atataatagt
    16921 acatgatcta aagattcatt tcttccttta gcagcttgaa taaaaatatt tagtttttct
    16981 ttagccttat cttgacctat atactcagta atccatttag gtctcaatgt caattcactt
    17041 tccaaatcct catttcttag acttccagcc actattctat cattaatatt ctccatttat
    17101 taaccccttc ttaatgtttt gataatcttt ttaatgtttc cctaattata tcttcaatac
    17161 tcatattgga tatgtccatg gtttttataa tcttctcaac ttctattctt gtatatccca
    17221 aagacattaa tccatttata gcttccatat agttatcata attcaagtca cttatattat
    17281 cttcttcaat tattatatcc ttatctatcc tatcttttaa ctctaatata attctttcag
    17341 cagttttttt cccaattcct ggtgccttac ataaaacatc taaatccttt ctcattatag
    17401 ctaatttaat ctggtttgaa tttagtgtag ataggatgcc taatgctatt ttaggcccaa
    17461 ttttagaaac catctgaagt aatttaaaca tattaagttc ttcttctgat ataaatccat
    17521 aaataaatat tccatcttct cttacattca aatatgtaaa aatcattgca tttttcatcc
    17581 ctaattcaat ttggatcatt gtattagtag atgtaaatat tttataacct attccattat
    17641 tctgcaatac tatataatct tctcttatag ctactatatc tccaataata aactcaaaca
    17701 aattattcac cctttatatt catatattat ttcattctaa aggcttcttt aaatttaata
    17761 gaacttccat gacatatggc tactgctaaa gcatctgcta catcatctgg tttaggcttt
    17821 tcttttaaat ttaatagtat ccttaccatt tcttgtactt gatttttatc tgctctccca
    17881 tatcctacaa cagattgctt tatctgcaag ggagtatatt catatatatt taacccttta
    17941 ttaacagctg ctagtatttc tacccccctt gcttgtccta cctttatagc tgtctttaca
    18001 tttttgttga aaaatagttc ttccactgct aaatcttcag gtttatattt ttctataatt
    18061 tcaataagtc tattatatat tatctttatc ctatcaggaa ataaaatatc tgaatctgtt
    18121 cttatacaac cataatcaat tgctttaaat ttatttccat tacattctat aatactatat
    18181 ccaactattg caattcctgg atcgattcct agaattatca tcctttatct cccttctata
    18241 actatattta ctattgtacc atatttacac ataaaaaact aagttagaaa atctaactta
    18301 gttaactaat aaaattctca agaatttcag acaattcatc ttcattatca actacaatcc
    18361 catctattat tttttcttga tcaatatcca ttaataatga aataggataa tcaactaaca
    18421 cattatctaa tactctttct ccattttctc caaccttaaa tattgctatc aaaccgtctt
    18481 tttctccaac tatataatga ttttcacata aatggttttt agtagttcct aatgttattt
    18541 tactagatga aaaagatatt aactttttat caggataatt ttcttgaata tattcaataa
    18601 attcttctct cgtcatattg accatattat cttctacaag attcgtcttt gtaacaacat
    18661 ggttacaagc catatagtga attctctctt ctataaaggt atttggagaa atcctattac
    18721 cctcaccaag tatttctttt tctggatgct ctaatatatc tttttctttt atatctattt
    18781 tgctaatgtc tttcgggttt aatcttttgc tcatcaattg atagccaaat ataaaactca
    18841 ctaaaaacaa ggttaaagaa aaaaagaaaa caggtaaaac tttgtctttt ttcataaata
    18901 tccctccaga ttactatcta gagggttatt atatccattt tacaattttt tatacaaaag
    18961 cacattattt ggtaacttca ccaatcttaa atcctgctga ttgaatttta tcaactaatt
    19021 tatctacatc atctgtatcc actctaagga taacttgaat taaatctaat acttttggat
    19081 ccataatggc aaaatttatt atatttatat tttcttttct aattacgtct gtaagtcttg
    19141 ctaactgtcc tggtaaatca aacatattta taacaattct agttccctta tctattccaa
    19201 atatttctga aaaagcatta aatattgcaa aatgagttaa tattcctaca aatttatcat
    19261 tagaatcaaa aacaggcaaa aacggtgttc taagctcttt taaaagataa gaagcttttt
    19321 caattctttc atctgcagaa atggactcat aattgttatt atatatttcc tctactttag
    19381 tgttgtttag atactcctct ttattacatt ttccagactc taaataattt ctataaacag
    19441 cttctttcat gagaataccc ttgaattctt taccatctat aactggtagg gataaaaaat
    19501 ttccctcatt gattttttca agggctctac ccaaactctc acctaactca actgtagtta
    19561 gtttttcttt tggcagcata taatttctaa taaacattta taatctctcc cctttaaata
    19621 ttatctatac ctctttaaca ctctatcatt tagtccgtac cagtatgcct ctttatagag
    19681 ttttaaacca tctttaagta ctatctttac catttcttta taaatactat ttaattcatc
    19741 taaagttaat aagttgtctt cttctttagt gttacaaggc tttgaattat attctattgt
    19801 cagctgttta tctaaatgtt catttaggtt aaaaatcttt gtccttaata gtttatgaca
    19861 ataatcccta ataatatcat ataaatattt attttgcttc tcaccttttt ggatttctcc
    19921 acctattaac gccttaacat ccgatatctg ttttatttta ttatcaaaat gatataaata
    19981 cttactttta tataatttat ctataggtgt attttttatt gctatttcct ctaagatatt
    20041 tacccaataa ttattaaaat aaccatgttt ataaccttct agataaataa acaactccaa
    20101 tctattaata tcttcatgaa ttagttgtcc aagatttagg gatatagaat aattcccttt
    20161 tctcttcttc aaaaatttgc tgatatgttt ttttagatta tgtatagata cgtacttggg
    20221 gcaaatgttt gttatatttt cttctaaatc atatagatta aggaggatat gtatgcaact
    20281 tatatcgtta ttataaagaa atttatatat taatccatca tagatactag atagttcatt
    20341 gtttgctatt gccatatcaa tacctccttt ttatcaattg ttgacaatcc tttgatgtat
    20401 taaacatttt aactataaat tttaaaggac agcaaagact attatactac ataattcttc
    20461 ataatagatt aaatttatat aataactttc ttacaaaatt ttaatatgta aaataaaaag
    20521 taatatattt aattaagtct tctagtcaag atttctataa tatcatcata agaactgtta
    20581 gattttattt tatatctccc agttctaatc tttttatcta gtttttttcc ttttacaaat
    20641 aaaacaaact catctacatc ctttattaaa tttgcatcat aaagattttt tgcaaccctt
    20701 gtaagattcg agccactttc tactataatt tctgtctcta ttattggttc tatgacttca
    20761 tcttctttct tttcttctat tggatcttct tttatattct ctacttctat gctttctttt
    20821 aagtttacca ttcccaattc ttttgctttt tctattattg cctcatcttc taagtctaaa
    20881 tactttatat taggattaaa ggaatataaa atattagtaa aaatcattcc aatacctata
    20941 cctaaagtta gatatgctaa cttaattctt ttattcatat ttataaatca cctcatatat
    21001 tattataata aatcaatact tattataaca tcttatttat aaatataata tgaataagat
    21061 actaatttca ttaatttata aaaaaatgcg tctatagaca cattttttat aaagcatatt
    21121 tttttaaact catacttaga aaattaaagt taaataaaat aatttttttc tattctctat
    21181 aatataaaaa acaaaccttt taaatgaaca tgcccctgtc aagtagacag tgaaaataat
    21241 aaaaactttg tgcgccaacc atttcattat gattggcgta tattcatttt aagcagctga
    21301 atctaaaaga taacgcctgt attctattgg agtcatgcac tgtaatcgtt tttgatacct
    21361 atgattattg taataattta tatattcaat aacagcagat tctaactcgg aatatgtgca
    21421 gaatt
//
