LOCUS       NZ_FQTY01000002        23231 bp    DNA     linear   CON 07-APR-2024
DEFINITION  Tissierella praeacuta DSM 18095, whole genome shotgun sequence.
ACCESSION   NZ_FQTY01000002
VERSION     NZ_FQTY01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Tissierella praeacuta DSM 18095
  ORGANISM  Tissierella praeacuta DSM 18095
            Bacteria; Bacillota; Tissierellia; Tissierellales; Tissierellaceae;
            Tissierella.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-NOV-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900128955.1-RS_2024_04_07
            Annotation Date                   :: 04/07/2024 13:22:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,187
            CDSs (total)                      :: 3,132
            Genes (coding)                    :: 3,083
            CDSs (with protein)               :: 3,083
            Genes (RNA)                       :: 55
            rRNAs                             :: 3, 1, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 1, 4 (5S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 13 of 49
            Pseudo Genes (incomplete)         :: 34 of 49
            Pseudo Genes (internal stop)      :: 8 of 49
            Pseudo Genes (multiple problems)  :: 5 of 49
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:14:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 406490
            Orig. end                         :: 429721
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FQTY01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23231
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23231
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23231
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:13231](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13231
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    32..44
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.54"
                     /tool="antismash"
     misc_feature    complement(845..860)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.02"
                     /tool="antismash"
     misc_feature    complement(1997..2010)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 23.16"
                     /tool="antismash"
     gene            2712..3743
                     /locus_tag="BUB33_RS04565"
                     /old_locus_tag="SAMN02745784_00929"
     CDS             2712..3743
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BUB33_RS04565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN02745784_00929"
                     /product="single-stranded DNA-binding protein"
                     /protein_id="WP_200778119.1"
                     /transl_table=11
                     /translation="MARKLRVKKQKYEMEEYSMSLKKGDIIKTALGDETTVLDVKDNQA
                     VLFSGKQFVIASGIRENKEAGKFEWANGRYAYDLKSISNMQNNSFESMKETLSFLAEYN
                     HSDFVKGIISLETGINNEDVLEDAYDNYMTDSTMGLIDEKFMDFIDEELAIAQDTKMNE
                     VQKEVDIQEQNGQEINEGEHAEIQENVAKEKTNTTVKDNKDQEKQYIKGNLTIDVEVKD
                     LKSNEGQDFRVASFSIAQNDEMGNVKFTNCFAYNEQIQAVESFKKGDFVSLSGKEKLTT
                     GKNGKQYTSFRIYSAKLLKSKEQSQDTKEKSSALEKLKSYKGKMDGKAIEQGNMKSEKD
                     IER"
     gene            3898..4410
                     /locus_tag="BUB33_RS04570"
                     /old_locus_tag="SAMN02745784_00930"
     CDS             3898..4410
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BUB33_RS04570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN02745784_00930"
                     /product="hypothetical protein"
                     /protein_id="WP_062624952.1"
                     /transl_table=11
                     /translation="MIGVFIVLIIMYIGIILFAGATFVKISLFAMDKLVVFIASWYYTH
                     HYFSVKFSSGYAVYFWDVLAAIFAVVIYTVLFKIIHNKLGVIGKILNLAISFFSSMTVY
                     CILVHGFITNGKSYFLPLLNHDLANQVVNYIIIAIISLAVWKRREDYLREAEGDKKEYY
                     IVEKTEE"
     gene            complement(4490..5863)
                     /locus_tag="BUB33_RS04575"
                     /old_locus_tag="SAMN02745784_00931"
     CDS             complement(4490..5863)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019034957.1"
                     /locus_tag="BUB33_RS04575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00931"
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_072973624.1"
                     /transl_table=11
                     /translation="MAVTKIHPIEKTLCLALNYIMNEDKTDEKILISSFGCNPKMAHLE
                     FEQTKRECNSKAKILARHLIQAFAPGETTPEQAHQVGLELCKRVLQGKYEYVLTTHIDK
                     GHLHNHIIFNNVSFESGKAYQSNKRSYHQIRMVSDELCKENGLSVIDEHYKKFKNRYST
                     NGKSYMEYSEFKRGSSWKNKLQLAIDKAILKSNTYEEFLKIMEEFGYEIKIGKYLSFRH
                     KDKKDIGRFTRAKASVLGEDYTKERIKERIEDPNKQHIYVNQECHYEKRSYKKMNTIVD
                     IKNNKKVKSSKGYEVWADKHNMKTMASSLNEMRRYGINSYEGLDLRLKELASDRQKILD
                     QIKQTEKEMQSIYSAIENKNTLYKNQLIYDMYLENKKDAVLYEEYKPQIIAYEIALKEL
                     KNSGYQTSDIKFLADKYSTLDQSKASFMSEYTAKNSMLHELQQAKKNTDLYLDNHLEK"
     gene            complement(5863..6231)
                     /locus_tag="BUB33_RS04580"
                     /old_locus_tag="SAMN02745784_00932"
     CDS             complement(5863..6231)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019117156.1"
                     /locus_tag="BUB33_RS04580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00932"
                     /product="conjugal transfer protein"
                     /protein_id="WP_072973626.1"
                     /transl_table=11
                     /translation="MTNRVRKHGIYLMLSDDELEILENKYKLSGCRTLRQFIMKCVLGK
                     DIFVLDMTVFRELSANVGRITGSINQIAKRVNSTGVIYKEDILDIKELLQRQGKDIYSL
                     RKKLYELGNLETVNTEGV"
     gene            6689..6916
                     /locus_tag="BUB33_RS04585"
                     /old_locus_tag="SAMN02745784_00933"
     CDS             6689..6916
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012858491.1"
                     /locus_tag="BUB33_RS04585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00933"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_072973627.1"
                     /transl_table=11
                     /translation="MENRIRDIRKRQKITQKEIAEKVKVTRQYVSLLEKSEIEPSLRVA
                     QGIAESLGCCLYYVFDIDGTGRYECSYCKV"
     gene            6959..7876
                     /locus_tag="BUB33_RS04590"
                     /old_locus_tag="SAMN02745784_00934"
     CDS             6959..7876
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010247638.1"
                     /locus_tag="BUB33_RS04590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00934"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_072973630.1"
                     /transl_table=11
                     /translation="MENTINIENLNKKYKDLTIVKSINMFVNKGEIYGLLGRNGAGKTT
                     IMKIILGLTKPTSGKVTVLGKDTSTVVGKDVLKKVGCIIETPGFYSNLTGAENLKIFAK
                     LRNIDENLVKEVLELVNLSYNDRKLFSKYSLGMKQRLAIANAIMHKPEVLILDEPINGL
                     DPIGIAEVRNLFKMFRQSGTSILISSHILSELENLADRIGIINDGNLIDEIDMVKWHAQ
                     NNGFIKIYAEDKEAVVKALFSVGLKEYELEITSNEIVVKAKNVTVSELSKIFANNNVDI
                     SGIIENKTTLEDYFKKVTGGQGIG"
     gene            7869..8603
                     /locus_tag="BUB33_RS04595"
                     /old_locus_tag="SAMN02745784_00935"
     CDS             7869..8603
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017644336.1"
                     /locus_tag="BUB33_RS04595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00935"
                     /product="ABC transporter permease"
                     /protein_id="WP_072973632.1"
                     /transl_table=11
                     /translation="MGRLLMTELQKGKRSKSLYISIILIIAYLSVVIFYTVSAVGLFDN
                     FMYLYKFSLSYMDYLILPMVLLSFLTSSFSCEYKSDTIKHIWTIPISRRKYFLSKLLYI
                     FLVALALMGIVFVTVCLASYFSRFRESMTFDLIIRFLELCVSSSLFVTMSIMPISIITI
                     VTKGNGAITNLAGSIYIVISFFLMKYLQGFSPLASAPHIIWYKNFEGVQNNSNVVFLLS
                     DVILVFFVYVVVSLKVLEEQDI"
     gene            8624..9349
                     /locus_tag="BUB33_RS04600"
                     /old_locus_tag="SAMN02745784_00936"
     CDS             8624..9349
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012858494.1"
                     /locus_tag="BUB33_RS04600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00936"
                     /product="ABC transporter permease"
                     /protein_id="WP_072973634.1"
                     /transl_table=11
                     /translation="MVYLGLEMKKMKRRKFLLVLTFVCFVTAIIQYAMGNMTYCGVKYG
                     SEVGWFFKNGLTTNSYYLLIPIFSLVGMELFLLEVRNNTLNNLLSIPIRKGDLIKSKML
                     LLFIISVIYTMLLFLLMFVLELSLNINSLDTGIVFLYIARYLVHGVICFIISAFIVSIM
                     LYLEQSIQVAVVTGFVLSFLGVFISQTEIAYIYFVNAMFYISGVVDSTVFEKLIASSVV
                     LFIAVLALFFYGKSVKREF"
     gene            9424..9651
                     /locus_tag="BUB33_RS04605"
                     /old_locus_tag="SAMN02745784_00937"
     CDS             9424..9651
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004167060.1"
                     /locus_tag="BUB33_RS04605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00937"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_072973636.1"
                     /transl_table=11
                     /translation="MSKKIENWKKSIYLKSENNDNPAGDIFRELSDNEIDGIMAGGTAN
                     SYCHCYSNKDSCGHGCTITTECPVATVICC"
     CDS_motif       9424..9549
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSKKIENWKKSIYLKSENNDNPAGDIFRELSDNEIDGIMAGG"
                     /locus_tag="BUB33_RS04605_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9550..9651
                     /prepeptide="core"
                     /locus_tag="BUB33_RS04605_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.10"
                     /molecular_weight="3341.8"
                     /monoisotopic_mass="3339.4"
                     /core_sequence="TANSYCHCYSNKDSCGHGCTITTECPVATVICC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSKKIENWKKSIYLKSENNDNPAGDIFRELSDNEIDGIMAG
                     G"
                     /leader_location="[9423:9549](+)"
                     /alternative_weights="3359.8"
     gene            10001..13231
                     /locus_tag="BUB33_RS04610"
                     /old_locus_tag="SAMN02745784_00938"
     CDS             10001..13231
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017644333.1"
                     /locus_tag="BUB33_RS04610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00938"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_072973638.1"
                     /sec_met_domain="DUF4135 (E-value: 7.5e-106, bitscore:
                     349.0, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3e-71, bitscore:
                     234.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSLEDFKNGTYSFERNKFDGNIDVNGKKISEIRSKYWKDFLGNE
                     FGNYEKYLSKEFNIKRNDFEQILSEQGFSIKKSEEIIMWEDFIELLQSCYCDDVQLHNF
                     YVVNEKSERVKPLFYTFYIPFVKVAIFKLKRYIRDYDVTEDIINQFTVQLLDKLTNISY
                     RTLILELNIAKEEGELKGESKEDRYQYFLEYCLIEKFWDYLEEYPVMFRLMVETVNNWI
                     LSTSEFIEHFYKDSLELNDVFGISNRIKKVDLSVSDSHNGGKSVIIVHTDNNKLVVYKP
                     RNLELDENFQKTLKLFNEVMGSELYSIKILNKGSYGWTEYVMHEPCKDGFDMETYYKEL
                     GELLFILYILRGNDIHYENIIAHGKHPVLIDLETVFHNKTNEFEKMSAADRIYEVIENS
                     VRRVGILPNIIWGKDGDVGVDVSAMTNEENKEIPIERASISSILTDEMRIDYRKSILKK
                     KSNAPFVRDVQIDVSKYKQNLKYGFINSYEKFLTDSNKIKLKIDTEKYNNIYSRQIMRA
                     TQYYSSMIQLSFHPDFLRSGLDREMLFSRLWIQVEEENKLERISGLEFLSMLKNDIPMF
                     LSKINSCDVQDGNGKIVEKFFKNSSVDLVIKKINNINKKDLKIQSLLITTALNYDPKYN
                     FAENKETKHEKILKITKKRRSYNDIKKEFIEISRNIANYLIENSFIGDNGDVSWIDMNI
                     VGEKTNDWNMVPIGLDLYSGVSGILIYFVYLYKETNNKKYLNVVRQCYESIRIYFDRKD
                     KYDRDKDKILFGGFSGETPLIYALIILEKELGDLFNLVEIESMRNSVLLSCEENLNKSK
                     DHDVIIGSAGVIVILLKYYEFTKKREILDIIKVYAEEIIKGFVTMDNGVIAWQGSFAKR
                     PLGGFAHGTSGIVWVLAKLYELTKDDRYLDIIERGLKYEDILYRANVNNWSDQRETDDG
                     IKYDDIDNNIPVAWCHGASGILLNRLCLKKMDIPLSSKRKQKIEVDIFNAIETCLKYGL
                     GRSHCLCHGDFGNIEILLFASEIMKDEKIKEKCDTYMEYILNDLKNGKWKCGIPYKDSP
                     GMMVGLSGIGYGLLKLCNPSLPSILLLE"
     gene            13242..15365
                     /locus_tag="BUB33_RS04615"
                     /old_locus_tag="SAMN02745784_00939"
     CDS             13242..15365
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004167044.1"
                     /locus_tag="BUB33_RS04615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00939"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_072973640.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.9e-34, bitscore:
                     111.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQVKFIQQLSETGCGVAAICMILDFYGCKTHIAELNKKINISRD
                     GVSLRELIKVSKIYGLTARAMQLQDKENIRQIYNELPCICLKNNNHYIVLCKIKNDFVS
                     YLDPEIGKVTVSIEEFNKSFTGIMLLLTPNKEFKKRKKKNYSFSLLKLGFLDKKMIVLA
                     IFLSVVIQMMTLFTPWITKYVIDDVVGKSANTNIFILFIYSIIFAFAYGLFSFIRYKII
                     SLLEKKYVSSLKKIIVEKTFKLPLKFFDIRSAGEIISRINSIDALQQIITNIVTSIFID
                     FTTVVIVAIVMLRSSVKLAYIIFAMGFILCVFLLFFLKTVDKKNLNSIMSREKTQSYLM
                     ESFSNITIMKTLGANKIVVGKWGEFYNKQISSEYIREKTLGLYQSFMLSYRLLPTFVIL
                     FIGSLLINDKVMSIGEMMAFISLTNLFLNPLATIMQNVFDFQYSTSIIDRLTEIVFEDE
                     EPVNDGKYIKNFEQLEFNNVDFSYDGRCGEKVLNNITFNLKKGDRISFVGRTGCGKTTI
                     VKLILMLYPYYNGNILINSENINKYNLKSYRKLFGIVLQDQMFFNDTIRNNIDIAQSHT
                     DDEVKQAIKIACFEADVEKMPFKMDTQIGDNGHNLSGGQRQRLAIARILINEPQIVILD
                     EGTNQLDAITEDRIMKNLKEKNISLITITHRLSTIVSSDKIFFLDNGKIVDSGEHIELK
                     ERNESYSRLFEKQ"
     gene            15709..16110
                     /locus_tag="BUB33_RS04620"
                     /old_locus_tag="SAMN02745784_00940"
     CDS             15709..16110
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010247195.1"
                     /locus_tag="BUB33_RS04620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00940"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_072973642.1"
                     /transl_table=11
                     /translation="MTDDRKYIYVKGKKIYVSDEIYKAYKKQLNHEAHVSRLDRKHKVY
                     GFEDYNVNIESIADTDIDIEKIIETKMRIEELYKALEKLNEEERKVIDSLYFKEMSIRD
                     LAEEQKVSSKKIFNFRNKILKKLKVLLNQ"
     gene            16538..17254
                     /locus_tag="BUB33_RS04625"
                     /old_locus_tag="SAMN02745784_00941"
     CDS             16538..17254
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BUB33_RS04625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN02745784_00941"
                     /product="hypothetical protein"
                     /protein_id="WP_072973643.1"
                     /transl_table=11
                     /translation="MLKKKSGWLSIVALMSILMVVSPMNVFAAESENTTRVNQDVTVEI
                     RDTNDLATLSDELDRFVQLNPDSTEEEQDAHLIEFIKNGGLSNNRIDSRGVGDYLPGYG
                     SLNPAERKLALAHPVQAVKVYNAGKTATNKTIEVYGQNGWQDNSDAFRHCLWNALMKQS
                     IGVSAAEKWATAHEYNSSGVDKAMDLHNNSIGRGINVSGQSTANIVDSVKAKVRDGSCR
                     RIINGSLVATDGSGMK"
     gene            17320..18354
                     /locus_tag="BUB33_RS16285"
                     /old_locus_tag="SAMN02745784_00942"
     CDS             17320..18354
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015338.4"
                     /locus_tag="BUB33_RS16285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00942"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_072973645.1"
                     /transl_table=11
                     /translation="MKIISKKHIIFGTLFLIYMIIVFSYSFFQKSNLNKVLSTKIFLLH
                     LYSFSIIFGFIISIISVVILIVMLYMNRYSYQNILFMGWIGILILSVILIIFGSDTKTK
                     GSTLNTTHTVKIVEWNTANNIDGKNIYTIFGEFDADIAVLPELEGYEKGDISQQRLKDL
                     FSAANLDFGKYESFVSLSTEGSIAPVTIIIKKGRCQFSNNKKVPMTRFGTIYLKSDSEQ
                     IPSIVGLHTAPPLPGLIDIWKKDLELISYDIVKEQPDAIIIGDFNATMRHGALNDIITH
                     EDVLNSLSIYNRGTWNVKLPYFFRTSIDHILIPKNQYLVKNIEVKNLYNSDHMAIFAEI
                     QRIE"
     misc_feature    complement(18568..18581)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.91"
                     /tool="antismash"
     misc_feature    complement(18579..18593)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 25.3"
                     /tool="antismash"
     gene            18645..18776
                     /locus_tag="BUB33_RS16730"
     CDS             18645..18776
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BUB33_RS16730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_268807660.1"
                     /transl_table=11
                     /translation="MEKLNIFADIRKQFFDNFIDQDRTLTIYRAAINKRQELSAEES"
     gene            18874..19050
                     /locus_tag="BUB33_RS16535"
                     /old_locus_tag="SAMN02745784_00943"
     CDS             18874..19050
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BUB33_RS16535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN02745784_00943"
                     /product="hypothetical protein"
                     /protein_id="WP_234949978.1"
                     /transl_table=11
                     /translation="MAAYCDDINGDNDTSTVVAGSSGKEAEVKFLCCVLIANTPVNVKK
                     LKFMRGEFSYERK"
     CDS_motif       18874..18936
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAAYCDDINGDNDTSTVVAGS"
                     /locus_tag="BUB33_RS16535_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       18937..19050
                     /prepeptide="core"
                     /locus_tag="BUB33_RS16535_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.30"
                     /molecular_weight="4210.0"
                     /monoisotopic_mass="4207.3"
                     /core_sequence="SGKEAEVKFLCCVLIANTPVNVKKLKFMRGEFSYERK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAAYCDDINGDNDTSTVVAGS"
                     /leader_location="[18873:18936](+)"
                     /alternative_weights="4228.0"
     gene            19037..19225
                     /locus_tag="BUB33_RS16540"
                     /old_locus_tag="SAMN02745784_00944"
     CDS             19037..19225
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BUB33_RS16540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN02745784_00944"
                     /product="hypothetical protein"
                     /protein_id="WP_072973647.1"
                     /transl_table=11
                     /translation="MKENKGNSTKDREVVGFTVKEAKEGQKIDQIEGIKIKVRFSDTGL
                     HLEHLVTAYIKEKLLMV"
     misc_feature    19383..19392
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 14.7"
                     /tool="antismash"
     gene            19398..21041
                     /locus_tag="BUB33_RS04640"
                     /old_locus_tag="SAMN02745784_00945"
     CDS             19398..21041
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000335328.1"
                     /locus_tag="BUB33_RS04640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00945"
                     /product="recombinase family protein"
                     /protein_id="WP_072973650.1"
                     /transl_table=11
                     /translation="MFKNKAVMYLRLSKEDGEAIESNSISNQREIIRAYLKNKDIQVVG
                     EYVDDGYSGANFQRPQFSRMIDDAYEKKFDTIIVKDLSRFGRDYIGAGRYIQRIFPEIG
                     IRFISVNDNYDSKHADMSDTHLILPIKNFINDSYSRDISNKVKSSQRVKRLNGEYIGAF
                     APYGYKKSEENKNKLVVDENVRNIIKAIFDMKLQGYSSKAIGDELNSLGIDSPKIYKEK
                     QGLNYKGGFEAVKGGNWSAKAINRIIENKIYIGVMQQGKSATISYKNKKQLEIHPSDWI
                     SVEDTHEPIISEEVFQIANVLLKRDFNTKVKQQVELFAGMLFCKDCNSPMVRRTVKTNK
                     KTDIFYICSKYNKEKTCTRHSIKLKALEEAITKLLKQYVSFNEKLYSIVKNIDFNVDIK
                     DSQIAILQREKEMTENLISSLYTDLEEDVITKEEYQLFRKNYLEQLSKLEENIKNRLEK
                     QRNIKESIQKNKNWIIDIKKYKELNTLDRLSVVMLIDRILIGENKEIEVVFNHAQKLEM
                     IEEITKEKSNKDRASLSEMGNVNRKVRYAR"
     gene            21090..22802
                     /locus_tag="BUB33_RS04645"
                     /old_locus_tag="SAMN02745784_00946"
     CDS             21090..22802
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012464.4"
                     /locus_tag="BUB33_RS04645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN02745784_00946"
                     /product="recombinase family protein"
                     /protein_id="WP_072973652.1"
                     /transl_table=11
                     /translation="MARTKKRYLETPQIEEIQKNSPIIYHAGIYVRLSHERTETYRNKS
                     SSISIQEEVCIEFAKEKGIAVEKTYCDYEYTGTNFERPAFKEMMQDIRNRKINCIIVRD
                     MSRFGREYLQIGNYIEKVFPFMGVRFISVNDRFDTIDRSDNKKNFEIVIKNLINDMYSK
                     DISTKVKTTKLTLAKSGFFIGTNAAYGYKVKKVTGGRKLEVDENTAPVVKQIFKWSLEG
                     DNQIVIARRLNEIGYTTAATYNKTGRMYQHKGDYQWRKGTVDNILVARVYTGALVQGVK
                     SQSLSQGKNQEILPKDEWIVIENAHEAIISEEDFEKVQQERLNRKQKREELKREKKLHS
                     KLKTITGIAPENRYKNLIFEKATGFQIPRHPESSGVIHKRISYVFDNNRSNGQIYDCPK
                     IRLKEETLDQLILQLIREQLQNISGVEKFKQKIELQGIIQLEKYQKEKDKFYASLDKKQ
                     LFMQKLYEKYVKGEIKKSEYLSYKDNLISEIKVIKKDIFQNDTKEKDLKYKKKEAIKWI
                     ELLYSASEKVKLSRELLVRLIEKIEVGENNHLDIKFRFTPAGLDRFGGDLFGE"
ORIGIN
        1 ctcaaaaagc tgaatgatga ttataaaaaa gatgacgttg taacctttga agagttgggg
       61 atcgataagc tctttgtgga tgaagcacat tcgttcaaaa atttgtatct cttttcaaaa
      121 atgcgaaatg tcgcaggaat tacaaacacc gattcgcaaa aatcgagcga tatgctgatg
      181 aaatgtcggt acatggatga gattacaaat aataaaggga ttgtatttgc aacaggaacc
      241 cctgtaagta attctatggc agagctatat accatgcagc gttatcttca gtatgatgaa
      301 cttaaaaaaa tgcacttaca acatttcgac tcttgggcat ctacttttgg agaaacggtt
      361 acagcaattg aacttaatcc tgaaggtaat ggatacagaa gtaagaccag atttgcaaaa
      421 ttttataacc ttccggaact gatgaatatg gtcaagcggt ttatggatat aaagactgct
      481 gatgtattaa atttaccaac accaaatgct cattatgaaa ccataaaaac caaaccgaca
      541 gaggagcaaa aggagatact ggagtctttt tctgaaagag cggataaagt tagggcaaaa
      601 caggtagatt cctctgtcga taatatgcta cttattacta atgacggaaa gaaaatggca
      661 ctggatcaaa ggctgatcaa tccattacta cccgatgatg aaaacagcaa ggtaaatact
      721 tgcataaaaa atgtgtttgc aatttgggat aaatatagga aagaaaaagc tactcaactt
      781 gtcttttgtg atctatccac accatccaaa gaatttaata tctatgacga tatgaagaat
      841 aagctgatag ctatgggcgt tcctgaaaga gagattgaat ttatccataa tgcaaagaac
      901 aacagggaga aggacgctat ctttgataaa gtaagaaaag gggaaattcg catacttctt
      961 ggttcgacgc aaaaaatggg ggcaggcacc aattgccagg ataaactgat agccattcat
     1021 gatttagatg tcccgtggag acctgcggac ctttctcaaa gagcaggtcg tattgtaaga
     1081 cagggtaatg aaaacagtga tgttcatatc tttaggtata taaccgaaaa tacctttgat
     1141 gcctaccttt tccaaactct tgagaataaa caaaaatata tctctcaaat tatgacaagt
     1201 aaaacacctg tacgtgttgc agaggatgtc gatgaggcaa ctttgaatta tgcggaaata
     1261 aaggctttgg ctgtgggaaa tccgcttatt cgtgagaaga tggatcttga tgttgaggta
     1321 agtaaactaa aaatgctgga gtctaatttt aaatccaatt tatataagct ggaggataag
     1381 gttataaagg tatatccgaa agaaattgaa agtctgaaag aaaaaataga acatttgaaa
     1441 aaggatatag aaagagtaga gccatataga gaagaaaata cagataaggt aggatatatt
     1501 cagtcaaact tggaaaatat aggagaaaat tcaaaagata tagagaaaaa ggcagataaa
     1561 gaaacagtgt caaaattcac atcccttatt cttgacggca aaaaatatac agataaaaag
     1621 atagccggag aatttttgat tagtaagata aaaagcataa gaaagacaga tggttttcgt
     1681 tctgaggaag tgaaaatcgg agagtatcga aactttgagt tgtttgcata ttatgacagt
     1741 ttttccaatc agtataaatt caatctcaaa ggagaagaaa accactacgg agagtttgga
     1801 acggatgaga taggaaatat aacaagaatg gacaatgtac ttgataaaat gcctgagaga
     1861 ttggaacaga cacttggaaa acttaaggat actgaaaatc aacttgaaac agcaaagctt
     1921 gaaatcgaga agaaatttcc acaggcagag cttttaaaag aaaagacatt aaggcttgct
     1981 gaggtaaatc atttgcttga tatgggacaa aaagaagatg taaaagagga taaaaatcca
     2041 cttttggaag aagtgaaaga agaactgatt cattttctaa acagggagta cgatgaagca
     2101 catagtataa aggattttga tacaatgttc cctgatttga cagatgtggg cttggcttat
     2161 acgactacac cggatgaaaa gcatgagata cagacaagcc ttgatttagt caattataag
     2221 ctgaatacct atgtagataa tactttaatt gatagtttta gttacatcta tgatccgctt
     2281 gatgcaagtg atacaaggga acttgtgcaa ataaaaacaa gcatagaact ttgggatttt
     2341 aatgaacttg tatatgtgaa cgaagaaaaa ttgaaagagg tgctaggact tgaaattgat
     2401 gacgatggta atttctatga tccgctctca aaagatatgg acttagacgg tgtgatagac
     2461 agatatgatg ccgattttcg agatagtaag gtgcaaagta taggtgattt ggataaaagg
     2521 gaaagaactt cagtactaga aaagttgaag gaatataagg acaaagcgga acaggtagaa
     2581 aataaagaag caaagataga gtgctgcgaa aaggaaagat agtataacta tgattttgta
     2641 gataaattat acagtaatta aataataaga tttagaaaaa gagtgctttg acaatttgtc
     2701 aggtactctt tttggctaga aagttaaggg ttaaaaagca aaaatatgaa atggaggaat
     2761 attctatgag tctaaaaaaa ggcgatatta ttaaaacggc attaggtgat gaaacaaccg
     2821 tactggatgt aaaagacaat caggcagtac tattttccgg aaaacaattt gtcatagcct
     2881 caggaattag ggaaaacaaa gaagccggta aatttgagtg ggcaaatgga agatatgcat
     2941 atgatctaaa aagcatttcc aatatgcaaa acaatagctt tgaaagcatg aaggaaactt
     3001 tatcattttt ggcagaatat aaccacagtg attttgtaaa aggaattatc tcacttgaaa
     3061 caggcataaa taatgaagat gtactggaag atgcctatga taattatatg actgattcta
     3121 cgatgggatt aattgatgag aagttcatgg attttattga tgaagagctg gcaatagccc
     3181 aagataccaa gatgaatgaa gtacaaaaag aagtagatat tcaggaacaa aatgggcaag
     3241 aaataaatga aggtgaacat gctgaaatac aggaaaatgt tgcaaaagaa aaaacaaata
     3301 caactgtgaa agataataag gatcaagaaa agcagtatat caaaggcaat cttaccattg
     3361 atgttgaagt gaaggactta aagtcaaatg aggggcagga ctttagagtg gcaagctttt
     3421 ccattgctca aaatgatgag atgggcaatg ttaagtttac gaattgtttt gcttataatg
     3481 agcagattca agcagtagag agctttaaaa aaggagattt tgtttcactt tcaggaaagg
     3541 aaaaacttac taccggaaaa aacggaaagc agtatacaag ctttagaata tattctgcga
     3601 aactattaaa atccaaagag caatctcagg atacaaaaga aaaatcttct gcacttgaaa
     3661 aactgaaaag ttataagggg aaaatggacg ggaaggcaat agagcaaggt aatatgaaaa
     3721 gtgaaaaaga tatagaacgc taaatgtaaa acaggggata aacggctaaa taagctgttt
     3781 atcccctgtt ttttcgctgg tcttctttct aaagttaaaa taaagatttg ctaaaataga
     3841 ataggagcgt tatatttata agaaaaatag aatgctttgg aaaggatgat gaatattatg
     3901 attggcgttt ttatcgtatt gattattatg tatatcggca ttatcttatt tgcaggagca
     3961 acatttgtaa aaataagctt atttgccatg gataagttag tggtgtttat agcaagttgg
     4021 tactatactc accattattt ttcagtaaaa ttttcatctg gatatgccgt atatttttgg
     4081 gatgtgttag cagcaatatt tgcggtagtg atatatacag tcctatttaa aatcattcat
     4141 aataaacttg gagtgattgg caaaattctt aacttagcta tttcattttt cagttctatg
     4201 acagtatatt gtattttagt acatggattt attacaaatg gaaaatccta ttttttacct
     4261 ctgttaaatc atgatttggc aaatcaggtg gtcaactata tcataatcgc tattatctcc
     4321 ttagctgtat ggaaaagaag ggaagattat cttagggaag cagaagggga taaaaaagaa
     4381 tactatattg tagaaaaaac agaggaatga tgagaattaa gcaggcttaa aaaacaaggt
     4441 ggggggatcg ttttatctaa gatttagata aaagtgatct cccttctttt tatttctcca
     4501 agtgattatc aaggtataaa tctgtatttt tcttggcttg ctgcaattca tggagcatag
     4561 agtttttggc agtgtattcc gacataaaag aagcttttga ttggtctaaa gtactgtatt
     4621 tatcggctaa aaacttaata tctgaggttt gatacccaga gtttttaagc tcttttaagg
     4681 ctatttcata ggcgataatt tgaggcttat attcttcata aaggacagca tcctttttat
     4741 tttccaagta catatcatag atcagttgat ttttatatag ggtattttta ttttctattg
     4801 cagaatatat ggattgcatt tctttttctg tctgtttaat ctgatccaag attttttgtc
     4861 tatctgaagc aagctctttt agtcttaaat ccaatccttc ataagagttt atgccatacc
     4921 ttctcatttc atttaaagag gaagccattg ttttcatatt atgtttatca gcccatacct
     4981 catagccttt agatgatttt acttttttat tgttctttat atctacaata gtattcattt
     5041 ttttgtagga gcgtttttca taatgacatt cctgattaac ataaatatgc tgtttattcg
     5101 gatcttctat tcgttcttta attctttctt tcgtataatc ttctccaagt acacttgcct
     5161 ttgctcttgt aaatctgccg atgtcttttt tatctttatg gcggaatgaa agatatttgc
     5221 caattttaat ttcataaccg aactcctcca ttattttcag aaattcttca taagtattgg
     5281 actttaaaat cgctttgtcg atagcaagct gtaacttatt tttccaagaa cttcccctct
     5341 taaattcgct atattccata tagcttttac catttgtaga atatctattt ttgaattttt
     5401 tatagtgttc atcaataacg gataaaccat tttctttaca aagttcatcg ctgaccattc
     5461 tgatttgatg ataacttctc ttattgcttt gatatgcttt tccagattca aagctcacat
     5521 tgttgaatat aatatggtta tgaagatgcc ctttatcaat atgggtggta agtacatact
     5581 catactttcc ttgcaagact cttttgcata actctagtcc tacttgatgt gcctgttctg
     5641 gtgtggtttc tcctggagca aatgcttgga ttaaatgtct tgctaagatt tttgccttag
     5701 aattacattc tctttttgtc tgttcaaact caagatgagc cattttagga ttgcaaccaa
     5761 aagaggaaat aaggattttt tcatctgttt tatcctcgtt cataatgtag ttaagagcta
     5821 agcataatgt tttttctatg gggtgaatct tggtaacagc cattagactc cctccgtgtt
     5881 tacggtttct aaatttccta actcatatag cttctttcgc aaagaataaa tgtcttttcc
     5941 ctgtctttga agtaactctt ttatatcaag aatatcctct ttataaatca caccggtaga
     6001 gttgactcgt tttgcaatct gattaatact gcctgttatc ctgccaacat ttgcagacag
     6061 ctctcggaaa actgtcatat ccagtacgaa aatatcctta cctaaaacac acttcataat
     6121 aaattgacgc aaagttctgc aaccggagag cttgtatttg ttctctaaaa tctctagttc
     6181 atcatctgaa agcattaaat aaatgccatg ttttctcact ctgtttgtca tcctaaaacc
     6241 tcctaaattc atataacata gtaaaaagac aaaagaaaaa acctgtaaaa tcaagtataa
     6301 aacttgactt acaggttttg ctttatggta tatttcctca tcggaaatct cctgcatgga
     6361 gataaaatag ttatatagaa tacaagaaca ttatatcatt tttgcaagaa agattcaatg
     6421 agggtagctg aacttttcta aaagatagtt aggtaacgcc ataaatcaag gatactcaca
     6481 taggggtttg gggatactcc ccaacaagca aaacggaaaa aaagaagcag cggcactctg
     6541 acctgcttag tccgtttttt cgtaagtgca tatgcactta ctgtgcttgc tcatatggat
     6601 atatttttta aaataggcaa tttacacttg cttttttcaa aagttaggta tataatacaa
     6661 taaaataaac agaaaagtaa gaaggataat ggaaaataga ataagggata ttaggaaaag
     6721 acaaaaaata acgcaaaaag agatagctga aaaagtaaag gtaactagac aatatgtaag
     6781 tctattagag aaaagtgaaa ttgaaccttc tctgagggtt gcacaaggaa ttgcagagtc
     6841 actcggctgt tgtttatatt atgtttttga tatagatgga acaggaagat atgagtgttc
     6901 gtattgtaaa gtgtgattaa agaagctgct gtgctttggt cttctgcgag gtgtttctat
     6961 ggaaaataca ataaatattg aaaatttgaa taagaaatac aaagatttaa ctatagttaa
     7021 atcaataaat atgtttgtga ataaaggaga gatatatggt cttctaggta gaaacggagc
     7081 aggaaaaact actataatga aaattatatt aggattaacg aaacctacga gtggaaaggt
     7141 tactgtgtta ggaaaggata ctagtacagt agttggcaag gacgtattaa aaaaggttgg
     7201 ctgtataata gaaactcctg gattttattc aaatctaact ggggctgaaa atctaaagat
     7261 ttttgccaag ttgagaaata ttgatgaaaa cttggtaaaa gaagtcttag aattggttaa
     7321 tttatcctat aatgatagga agcttttttc aaaatattcg ttaggaatga aacaaagatt
     7381 agcgatagct aatgcaatta tgcacaaacc tgaggtattg attctggatg agccgattaa
     7441 tggattagat ccgataggta ttgctgaggt gcggaattta tttaaaatgt ttagacagtc
     7501 tggtacaagc attttaatat caagccatat tttgtcggaa ttagaaaatt tagcagatag
     7561 gataggtatt attaatgatg gtaatttgat tgatgaaata gatatggtga agtggcatgc
     7621 tcagaataat ggatttatta agatatatgc agaggataaa gaagctgtag tgaaggcttt
     7681 gtttagtgtt ggtttaaaag aatatgaatt agaaatcact agtaatgaga ttgtggtgaa
     7741 agccaagaat gtaactgttt cagaattgag taaaattttt gcaaataata atgtagatat
     7801 ttctggaata atagaaaata aaactactct tgaggattat tttaaaaaag ttacaggagg
     7861 tcaggggatt gggtaggtta ttgatgacag aattgcaaaa aggtaaaaga tccaaatcgc
     7921 tatacatatc tattatactt attattgctt acttgtcagt ggtaatattc tatacagtaa
     7981 gtgcagttgg gttgtttgat aattttatgt atttgtataa attttctctg agttatatgg
     8041 attatttgat tttaccaatg gttttgctgt cgtttttaac aagcagtttt tcttgtgagt
     8101 acaaaagtga tactattaag catatttgga ctatacctat atcaaggaga aaatattttt
     8161 tatctaaatt gctgtatata tttttagtgg ctttagctct tatgggaatc gtttttgtaa
     8221 cagtatgttt ggcaagttat tttagcaggt ttcgtgagag tatgacattt gatttgataa
     8281 taagattttt agaattgtgt gtgtccagtt cgctttttgt tacaatgagt attatgccga
     8341 tatcaatcat tactatagtt acaaaaggca atggagctat tactaactta gctggaagta
     8401 tttatatagt gatatcattt tttttaatga agtatttaca aggatttagt ccgttagcaa
     8461 gtgcgcctca tattatctgg tataaaaatt ttgaaggggt tcaaaataat tctaatgtag
     8521 tgtttttgtt atctgatgtt attttggtat tttttgtata tgtagttgtt tcattgaagg
     8581 tattagaaga gcaagatata tagatttatc aggaggaatt tgaatggtat atttgggctt
     8641 ggaaatgaaa aaaatgaaac gaaggaaatt tttactggtc ttgacttttg tttgtttcgt
     8701 tacagctatt atacaatatg caatggggaa tatgacttat tgtggtgtga aatatggttc
     8761 tgaagttggt tggtttttta aaaatggact aacaaccaat tcttattatt tgcttatacc
     8821 gattttctcc ttagttggaa tggaattatt tttgctggaa gttcgtaata atacgcttaa
     8881 taatttattg agtataccta taaggaaagg tgatttaata aagtctaaga tgttgttatt
     8941 gtttataata tctgttattt acacaatgtt attattcttg ctgatgtttg tattggagtt
     9001 aagcttaaat ataaattcat tagatactgg tattgtattt ctttacatag cgaggtattt
     9061 agtgcatgga gtcatatgtt ttattatctc tgcttttata gttagtataa tgttatattt
     9121 ggaacaaagc attcaagtag ctgttgtgac tggatttgtg ctttcgtttt taggagtatt
     9181 tatatctcag acagaaatag catatattta ttttgtgaat gcaatgtttt atatttcggg
     9241 agttgttgat tctacagttt ttgaaaagtt gattgcaagt agtgtagtgt tgtttattgc
     9301 ggtgctggct ttgttttttt atggtaagag tgtaaaacga gagttctagg gttcgataaa
     9361 taaagtacgt ggtaaatctt cgtgctgtta tttataaatt tttgaagaaa ggaggaagca
     9421 aagatgtcaa agaaaataga aaactggaag aaatccattt atctcaaaag tgaaaataat
     9481 gataatccag ctggagatat ttttcgtgaa ttatctgaca atgagattga tggaataatg
     9541 gcaggcggaa cagcaaactc atattgccat tgctattcaa ataaagactc ttgtggtcat
     9601 ggttgcacaa taactacaga gtgtccagtc gcaacagtaa tttgttgcta gtatgggtgt
     9661 tgcgaaacga gaggtaggtg ttgcatctgc ctctcgtttt gtttatttgt agtagaaatg
     9721 ctaaaattaa gactcatttg tagtgaagga agacttgata atgtgaatat tagtaaaaac
     9781 ttatataaca aagaagatgt ttataataga ccatagtgaa atttgcaaac gaaataaatt
     9841 agtaacagag attgaaaata tgggtgagtt taatcaatat gttagttaga aattaacact
     9901 actataaaaa ttggaaaata caaatttata tagtttaaga gagtgtgaaa aaaaataaat
     9961 ttttgattag agaaaaaatt attgtataag gagagttaat atgaaatcat tagaagattt
    10021 taagaatggt acttactcat ttgaaagaaa taagtttgat gggaatatag atgttaatgg
    10081 gaaaaaaata tcagaaataa gaagtaagta ttggaaagat tttctaggaa atgagtttgg
    10141 gaattatgaa aaatatttat ctaaggaatt taatattaaa agaaatgatt ttgaacaaat
    10201 tttatctgaa caaggttttt cgatcaagaa atcagaagaa attattatgt gggaggattt
    10261 tattgagtta ctacaatctt gttattgtga tgatgttcaa ctacataact tttatgttgt
    10321 aaatgaaaaa agtgagaggg taaaaccttt attctataca ttttatattc cgtttgttaa
    10381 agtagctata tttaagctaa aacggtatat tagagattat gatgttacag aagatattat
    10441 aaatcaattt acagttcaac tattagataa attgacaaat attagttata gaacattgat
    10501 cttggaatta aatattgcaa aagaagaggg agaattaaaa ggagaaagta aggaagacag
    10561 gtatcaatat tttttggagt attgccttat agagaagttt tgggattatc ttgaagaata
    10621 tcctgtaatg tttaggttaa tggtggaaac tgtgaataac tggattttat caacatctga
    10681 gtttatagaa catttctata aagattcttt agaacttaat gatgtttttg gtatttcgaa
    10741 tagaataaaa aaagtagact taagcgtgtc tgactcacat aacggtggaa agtctgttat
    10801 tatagttcac acagataata ataaactggt agtatataag ccaagaaatt tagaattaga
    10861 tgaaaatttt caaaaaacac taaaattatt taatgaggtt atgggtagtg agctgtattc
    10921 tataaaaata cttaacaaag gttcatatgg atggacagaa tatgttatgc atgagccttg
    10981 taaagatgga tttgatatgg aaacatatta caaggaatta ggggaattac tattcatttt
    11041 atatatttta aggggaaatg atatacatta tgaaaatata attgcacatg gaaagcatcc
    11101 tgtattgata gatttagaaa ctgtatttca caacaaaaca aatgaatttg aaaaaatgtc
    11161 tgctgcggac agaatatatg aagtgattga aaattcagta agaagagttg gcatattgcc
    11221 aaatataata tggggtaaag atggtgatgt tggagtagat gtgagtgcta tgacaaatga
    11281 agaaaataag gaaattccta tcgaaagggc aagtatttca agtatattga ctgatgaaat
    11341 gagaatagat tatagaaaat caatattaaa gaaaaaaagt aatgctcctt ttgtaagaga
    11401 tgtccaaatt gatgtttcta aatacaaaca gaatttaaag tatggtttta ttaatagtta
    11461 tgaaaaattt ttgacagaca gtaataaaat caagctgaaa attgatacag aaaagtacaa
    11521 taatatttat tcaagacaga taatgagagc aacacagtat tattcatcta tgatacaact
    11581 gtcttttcat cccgattttc tgcgcagtgg attagatagg gaaatgttat tttcaagatt
    11641 atggattcaa gttgaggaag aaaataagtt ggaaagaatt tcagggttag aatttttatc
    11701 catgttgaaa aatgatattc caatgttttt atcaaaaatt aattcttgtg acgttcaaga
    11761 tggaaacgga aaaattgttg aaaagttttt taaaaatagt tcagttgatt tggttataaa
    11821 aaagataaat aatattaata aaaaggattt gaagatacaa tctttattaa taacaactgc
    11881 cttaaattat gatccaaagt ataattttgc agaaaataaa gaaacaaaac atgaaaaaat
    11941 attaaaaata acaaaaaaac gcagatctta taatgatata aaaaaagagt tcatagaaat
    12001 atctagaaat atagctaatt atttaattga aaattcattt attggtgata atggggatgt
    12061 tagttggata gatatgaata ttgttggcga aaaaacaaat gattggaata tggtgccaat
    12121 aggtcttgat ttgtatagtg gagtttctgg aatattaatt tactttgttt acttatataa
    12181 agaaactaat aataaaaagt atttgaatgt agtaagacaa tgttatgaaa gcataagaat
    12241 ttattttgat agaaaagata aatatgatag agataaagat aaaatacttt ttggtgggtt
    12301 ttctggagaa actccattaa tatacgctct gattatccta gaaaaagaac tcggggattt
    12361 atttaacttg gttgaaattg aatcaatgag aaacagtgta ttattgagtt gtgaagaaaa
    12421 tctcaataaa agtaaagatc atgatgtgat aattggttct gctggagtta ttgtaatact
    12481 tttaaaatac tatgagttta caaaaaagag ggaaatttta gatattatca aggtttatgc
    12541 agaagaaata ataaaaggct ttgtaacaat ggataatgga gtcatagcat ggcaaggatc
    12601 ctttgcaaaa agaccattag gaggttttgc tcatgggaca tcaggaatag tttgggtgct
    12661 ggctaaattg tatgaactta cgaaagatga tagatactta gatattatag aaagaggatt
    12721 aaagtatgaa gacatactct atcgagcaaa tgtgaataat tggtctgatc agagggaaac
    12781 tgatgatgga ataaaatatg atgatataga caataatata ccagtagcct ggtgtcatgg
    12841 agcaagtggt attttgttaa atagactatg tttaaaaaaa atggatattc cgctttcatc
    12901 aaagagaaag caaaaaattg aagtagatat ttttaatgca attgaaactt gtttaaagta
    12961 tggattggga agaagccact gcttatgtca tggagatttt ggtaatattg aaatattact
    13021 ttttgctagt gaaattatga aagatgaaaa aataaaagaa aaatgtgata cttatatgga
    13081 atatattttg aatgatttaa aaaatggaaa atggaaatgt ggaataccat ataaggattc
    13141 acctggaatg atggttggat tatcagggat agggtatgga ctattaaaat tatgtaatcc
    13201 tagtttaccg tcaattctgt tattggaata ggaggtataa cttgaaacag gttaagttta
    13261 tacaacaatt atctgaaaca ggatgtggtg tagctgctat ttgtatgata ttggattttt
    13321 atggctgtaa aacacacatt gctgaattga acaaaaaaat aaatatttca agagacggtg
    13381 tttcacttag ggagcttata aaggtttcaa aaatctatgg gctaacagca agagcaatgc
    13441 aattgcaaga caaagaaaac ataaggcaaa tatacaatga actaccatgt atttgtctta
    13501 agaacaataa tcattatata gtactttgca aaataaaaaa tgattttgtg tcttatctag
    13561 acccagagat tggcaaagta actgtgagta ttgaagaatt taataaatct tttacaggaa
    13621 taatgttgtt gcttacacct aataaggagt tcaaaaaaag gaagaaaaag aattatagtt
    13681 ttagtttatt aaaattgggt tttcttgata aaaaaatgat tgttttagca atatttttgt
    13741 cagttgtaat tcaaatgatg actcttttta ctccatggat aacaaaatat gtaatagatg
    13801 atgttgtagg aaaaagtgca aatacaaaca tatttatttt gtttatatat tctataatat
    13861 ttgcttttgc gtatgggtta ttttctttta taaggtataa aataatatca ttgttagaga
    13921 aaaaatatgt ttcttcttta aaaaaaataa ttgtagaaaa aacttttaaa ctaccattaa
    13981 agttttttga tattagatca gcaggagaaa ttatttcaag aataaatagt attgatgcgc
    14041 ttcaacaaat tataacaaat attgttactt ctatctttat tgattttaca acagtagtga
    14101 tagtagctat agtaatgctt agaagttctg tgaaattagc ttatataatt tttgcaatgg
    14161 gttttatttt atgtgttttc ctactatttt ttcttaaaac agtagataaa aaaaatttaa
    14221 attctattat gagcagagaa aaaactcaaa gttacttgat ggaaagtttt tcaaatatca
    14281 ccattatgaa gacattaggt gcaaataaaa tagttgtagg taaatggggt gagttttata
    14341 acaagcaaat ttcttcagaa tatattagag agaaaacgtt gggactttat caaagcttca
    14401 tgctctcata cagattatta ccaacttttg taatattatt tataggtagt cttttgataa
    14461 atgataaagt catgtctatt ggagaaatga tggcttttat atcattaact aatctttttc
    14521 taaatccttt agcgacaatc atgcaaaatg tatttgattt tcagtattca acatctatta
    14581 ttgacagact tacggaaata gtgtttgaag atgaagaacc agtgaatgat ggaaaatata
    14641 taaaaaattt cgagcaatta gaatttaata atgtagattt ttcatatgat ggaaggtgtg
    14701 gagaaaaagt tcttaataat attacattta atttgaaaaa aggagataga atatcttttg
    14761 ttggtagaac ggggtgtggg aaaactacaa tagtaaaatt gatattgatg ttatatccat
    14821 attataatgg gaatatactt ataaactcag aaaatataaa taaatataat ttgaaatcat
    14881 acagaaaatt gtttggaatt gtgctgcaag atcaaatgtt ttttaatgat actataagga
    14941 ataatattga tattgctcaa tcgcatacag atgatgaggt taaacaggct ataaaaattg
    15001 cttgttttga agctgacgta gaaaaaatgc cttttaaaat ggatacacaa attggtgata
    15061 atggacataa cttgtcagga ggacaaaggc agagattagc aatagctaga attttaatta
    15121 atgagcctca aattgttatt ttagatgaag gtacaaatca attagatgca attacagagg
    15181 atagaattat gaagaattta aaagagaaaa atatatcatt aataacaata acacataggc
    15241 tttcaacaat agtatcatca gacaaaatat tttttttaga caacgggaag attgtggata
    15301 gtggtgagca tatagaatta aaagaaagga atgaatctta tagtaggctt tttgaaaaac
    15361 aatgatacca aatgtaatta agaaatgaga tttaaataaa tttttatatg ataaaattat
    15421 tagaaattta agtctaataa tttattttta ggagggatag aattatttaa attggattgt
    15481 tagaattaat gaatatggag catattatga aaagagtatt tttattatta aaagagtatt
    15541 tattaacgaa gatattacct ttttatagtt aaaataaatc agcttatttt agataaaaga
    15601 tacttttcgt ataatttaag aggactttgc atgtcaaaat gcagaagtcc tcctttttta
    15661 ttttcaaaac ttttcgttgt caaaaaataa aaaaggagga ttttgcaaat gacagatgat
    15721 aggaagtata tttatgtaaa aggtaaaaag atatatgtgt cagatgaaat atataaagca
    15781 tataagaaac agctcaatca tgaagctcat gtaagtagac ttgacagaaa gcataaggtc
    15841 tacggttttg aagattacaa tgtcaatata gagtccattg cagatacaga tatagatatt
    15901 gaaaaaatca ttgaaaccaa gatgagaata gaggagctgt ataaagcact tgagaagctc
    15961 aatgaggaag aaagaaaagt aatagattct ttgtatttca aagagatgag cattcgtgat
    16021 ttagcagaag aacaaaaggt gtcttcaaag aagatattta actttagaaa caaaatttta
    16081 aaaaagttaa aagtgctgct taatcagtaa ataactgata gggagcagat gggagacgat
    16141 ttgctcccta tctaaaagaa tctaaaaatt ggaaataaaa gtctataaaa atagaaatta
    16201 tagtagtaaa aagatatttg tcttataaaa gttgaatata ttttgtaagt atcaaagtgc
    16261 catttctagt aattaaatag aaaaataatt aattgtaaaa taaacaacta tattacttgc
    16321 aaaattaaat tagttaggat acactgacta tagtaaagag ttatggtgat ttcgagaata
    16381 gaactattcg ttgatataat tttagaaagt gaggtgattg agatgtttat aagtggtctt
    16441 taaaattaga gagatgggga tggacataga aggatgctcc aaaattacaa tttaataaaa
    16501 aagataggtt gtatttaaag gaaggatggg aaattagatg ttaaagaaaa aatctggatg
    16561 gttaagtata gtagcattaa tgagcatatt aatggtagta tctcccatga atgtatttgc
    16621 tgcagaaagt gaaaatacaa caagagttaa tcaagatgtt acagttgaaa ttagagatac
    16681 taatgattta gcaacattat cggatgagtt agatagattt gttcagttaa atccggatag
    16741 tacggaagaa gaacaggacg cacatcttat agagtttata aaaaatggtg gtttaagcaa
    16801 taatagaata gactcaagag gtgtgggtga ttatcttcct ggatatggta gtcttaatcc
    16861 tgctgaaaga aaattagcac ttgcacatcc tgtacaagct gtaaaggtat ataatgcagg
    16921 aaaaactgct accaataaaa caatagaagt atatggtcag aatgggtggc aggataattc
    16981 agatgctttt agacattgtc tgtggaatgc tttaatgaaa caatccatag gtgtgtctgc
    17041 agctgaaaaa tgggctactg ctcatgagta taactcaagt ggtgtagata aagctatgga
    17101 tttacacaac aatagtattg gtagaggaat taatgtttca ggacagtcaa cagcaaacat
    17161 tgtagattca gtaaaagcaa aggtaagaga tggatcttgt agaaggatta taaacggttc
    17221 gttggtggct actgatggtt ccggaatgaa atagataaat atattagata gcgactttaa
    17281 gttttttaaa gtcgctatct ttaaaattat ggagggaaaa tgaaaataat atcaaaaaaa
    17341 catattattt ttggaacgct attcttaata tatatgataa tagttttttc ttacagtttt
    17401 tttcaaaaaa gcaatttaaa taaggtatta tcaacaaaga tttttttatt gcatttatat
    17461 tcattttcga ttatatttgg ttttattatc tctatcattt cagtagtaat tttaatagtt
    17521 atgttgtata tgaatagata ttcttatcaa aatatattat ttatgggttg gattgggata
    17581 ttgattttat ctgtaatact tataatattc ggatcagaca caaaaacaaa gggtagtact
    17641 ttaaatacaa cacatactgt taaaattgtt gaatggaata ccgctaataa cattgacgga
    17701 aaaaacattt acacgatatt tggagaattt gatgctgata tagctgtttt acctgaattg
    17761 gaaggatatg aaaaaggcga tatatctcaa caaagattga aagatttatt tagtgcagcc
    17821 aatttggatt ttggtaaata tgagtcattt gtctcgcttt ccaccgaagg tagcattgca
    17881 ccagtgacta taattatcaa aaaaggaagg tgtcaattta gtaataacaa aaaagtacct
    17941 atgactagat ttgggacaat atacttaaaa tcagattcag aacaaatacc tagtattgta
    18001 ggactacaca cagctcctcc attgccaggt ttgatagata tttggaaaaa ggatttagaa
    18061 ctaatttctt atgacatagt taaagaacag cccgatgcta taattatagg agattttaat
    18121 gctactatga ggcatggagc cttaaatgat ataataacac atgaagatgt attaaatagt
    18181 ttatctatat ataatagagg aacatggaat gtgaaattgc catatttttt tagaacatca
    18241 atagaccata ttttaatacc taaaaatcaa tatttggtaa agaacataga ggtaaaaaac
    18301 ttgtacaatt cagatcatat ggcaatattt gccgaaatac aaagaataga ataaatttat
    18361 aatatatgat taaaaaatta aaggtttata gaactagttt aacttggcga ttaagagaaa
    18421 aaatcttaat cgccttatat ttttaataag tttcaatttg aacaaagcta attcttataa
    18481 acaagtgagc agaatgagtt aacataacat tgttatttct ttaatattta gaatactttg
    18541 tatattaagg tatgaaggag ctattttttt ttttgaaaaa ttttctaaaa aatggaaaca
    18601 aaagtccttg aaagtaaggt ttatatatag agggagtttt aaccttggaa aaattaaata
    18661 tatttgcaga tataagaaaa cagttctttg acaacttcat agaccaagac aggacgttaa
    18721 ccatttatag agcagctatc aacaaacgcc aggagctttc tgctgaggaa tcttagattt
    18781 aaatttttta ggtattttct cggtttaaac gaatacttgc aaaagcaaag gatagaagaa
    18841 agtgagcgat aaatttgaag ataggaaata ggtgtggcag cctattgcga tgatataaat
    18901 ggggataatg atacttctac agttgttgcc ggctcatctg gaaaagaggc ggaggtgaaa
    18961 ttcctatgtt gtgtgctaat agccaacaca cctgtcaatg tcaaaaaact taaatttatg
    19021 agaggagaat tttcttatga aagaaaataa gggaaattcc acgaaagata gggaagtcgt
    19081 gggatttaca gttaaggagg caaaagaggg gcaaaagata gatcaaatag aaggtattaa
    19141 aattaaagta agattttcag atacaggact tcatttagag catttagtga cggcgtacat
    19201 taaagaaaaa ctgcttatgg tataggatga tggtaaagta caatgaataa gttgtataat
    19261 tccatcatta taatctgaaa ataaaaaaat atagcatagg tattgcaatg aaatatgagg
    19321 agcgttataa taaatgcgtg gaagcctaac ctttatattt ggtttattgt ataaatcaaa
    19381 ttgaaggggg cttttttgtg tttaaaaata aagcagtaat gtatctaaga ctatccaagg
    19441 aagatggaga agcgatagaa agcaactcca ttagcaatca gagagaaatc attagagcat
    19501 atcttaaaaa taaggatatt caagttgttg gagagtatgt tgatgacggc tactccggag
    19561 ctaattttca gcgtcctcag ttcagtcgga tgatagatga tgcctatgag aagaaatttg
    19621 acaccattat tgtaaaagac ctgtccagat tcggacggga ttatatcgga gcaggaagat
    19681 atattcagcg gatttttcca gagataggga taagatttat atccgttaat gacaattatg
    19741 acagcaaaca tgcagatatg agcgacacgc accttattct tccgattaag aactttatta
    19801 atgacagtta ctcaagagat atttcaaata aagtgaaaag ctcacaaaga gtaaagcgac
    19861 tgaatgggga atatatcggt gcctttgcac cctacggcta taagaaaagt gaggaaaata
    19921 agaacaaact tgtggttgat gaaaatgtaa gaaatatcat taaagctatt tttgatatga
    19981 aattacaagg ctattcgtca aaagcaatcg gagatgaact caacagctta ggcatagatt
    20041 ctccgaaaat ctataaagaa aagcagggtt taaactataa gggtggcttt gaagcggtga
    20101 aaggcggaaa ctggtctgca aaagctatca atcgtattat agaaaataaa atttatatcg
    20161 gcgtgatgca gcagggtaaa agtgcaacca tcagctacaa aaataaaaag caattagaaa
    20221 ttcacccgtc tgattggata agtgtagaag atacccatga gcctattatc agtgaagaag
    20281 tgtttcaaat cgcaaatgta cttttaaaaa gagatttcaa caccaaagtc aagcaacaag
    20341 tggaattatt tgcaggtatg ctgttttgta aggattgcaa cagccctatg gttcgtagga
    20401 ctgtaaaaac caataaaaaa actgatattt tctatatatg ctccaaatac aataaagaga
    20461 agacctgcac aagacacagc attaaactga aagctttaga agaagcgata actaagttgt
    20521 taaagcaata tgtttccttt aacgaaaagc tttatagtat tgtaaaaaat attgatttta
    20581 atgtggatat taaggatagt caaattgcta tcttacaacg tgaaaaggaa atgacagaaa
    20641 atcttatttc atccttatat acggatttgg aagaggatgt tattacaaaa gaggaatatc
    20701 aactttttcg gaaaaactac cttgagcaac tttcaaagct tgaagaaaat atcaagaata
    20761 ggttggaaaa gcaaagaaac atcaaagaaa gcattcaaaa gaataagaat tggattattg
    20821 atattaaaaa gtataaagag ctgaatacgc ttgacagatt atcagtggta atgctgattg
    20881 acagaatcct gattggagag aacaaagaaa ttgaagttgt ttttaaccat gctcagaaat
    20941 tagaaatgat tgaagaaatc acaaaagaaa aaagcaataa ggatagggca tctctttctg
    21001 aaatgggaaa cgtaaatagg aaagtgaggt atgccagatg aagaaaaata caatatttct
    21061 gaagaataat aaaaatgcga ggtggtacta tggcaagaac taaaaaaaga tacttggaaa
    21121 cacctcaaat agaagaaata cagaaaaata gtccaatcat ctatcatgcc ggaatttatg
    21181 taagactatc tcatgaaaga acggaaacct atcgaaacaa aagcagttca atttctatac
    21241 aagaagaagt ttgtatagaa tttgcaaagg aaaaaggaat tgcagttgaa aaaacatatt
    21301 gcgactatga gtatacaggt acaaattttg agcgacccgc ttttaaggaa atgatgcagg
    21361 atattagaaa taggaagatt aactgtatta ttgtaagaga tatgtccaga tttggcagag
    21421 aatatttaca gataggaaat tatattgaaa aggtgtttcc gtttatgggg gtaagattta
    21481 tatcagtaaa tgatcgcttt gatacaatag acagatctga taacaaaaag aactttgaga
    21541 ttgtcataaa aaatctgatt aatgatatgt actcaaagga catttcaaca aaagtaaaaa
    21601 caacaaagct tactctggca aaaagtggct tttttattgg aacaaatgca gcctatggtt
    21661 ataaagtaaa aaaggttaca ggaggcagaa aattagaagt tgatgaaaat accgctcctg
    21721 tggtaaagca gatttttaag tggagcttag agggagataa tcaaatagta attgccaggc
    21781 gtttaaatga aattggctat acaacagctg ccacatacaa caagacagga agaatgtatc
    21841 agcataaagg agattatcag tggcgaaaag gcaccgtaga taatattctt gttgcaagag
    21901 tatatacagg agctttggtt caaggtgtta aaagccaaag cttatctcaa ggtaaaaatc
    21961 aggagatatt gccaaaggat gagtggattg tcatagaaaa tgcacatgaa gccatcatat
    22021 ctgaagaaga ttttgaaaaa gtgcagcaag aaagattaaa cagaaagcaa aaaagagagg
    22081 agttaaaaag agaaaagaaa cttcattcaa agcttaaaac tataacaggt atagcaccgg
    22141 aaaatcgcta taaaaatctt atatttgaaa aagcaacagg atttcaaatt ccaagacatc
    22201 cggagagcag tggtgtcatt cataaacgga tcagctatgt ttttgataac aaccgctcga
    22261 atggtcagat atatgattgt cctaaaattc gtttaaaaga agaaacactc gatcagctga
    22321 ttttacagtt aatcagggag cagttgcaaa atatatctgg agtagagaaa tttaagcaaa
    22381 aaatagagct tcaagggata atacagcttg agaagtatca aaaggaaaaa gataagttct
    22441 atgcttcatt ggataaaaag cagttattta tgcaaaagct atatgaaaaa tatgtaaagg
    22501 gcgaaataaa aaaatcagaa tatctttctt ataaagacaa tttaatttct gaaattaagg
    22561 tgatcaagaa agatattttt caaaatgata cgaaagagaa agacctcaaa tataagaaaa
    22621 aagaagctat aaagtggata gaactattat attccgcttc agagaaagtg aaactttcaa
    22681 gagagctgtt ggtaaggctg atagaaaaaa tagaagtagg agaaaacaat catttggata
    22741 ttaagtttag gtttactcct gctggcttag atagatttgg aggtgatctg tttggagaat
    22801 aatattgctt tttacatgag attgtcggtt gatgaaaaag aaaagttgga aagtgaaagt
    22861 atatccaatc aaagattact tttaaaacac tatatctctc ttgataagga tttaaatgcc
    22921 ttcaatatca aagagtatgt agatgacggt tatagtggaa cctcattaaa cagaccggca
    22981 ctgcaaagat tatttggaga tgtaaaaatt gggaaagtaa actgcattat cgtaaaagat
    23041 atttcaaggt ttatgagaga ctatattaca cttggagatt atcttgaaaa tatctttccg
    23101 tttctcggca tccgctttat ttcagtaaat gatggctatg atagccaaaa agagtcagac
    23161 actggaatag atataggtat tcaatttaag ggacttctat cagattttta tgcaaaagaa
    23221 actgctgaaa a
//
