LOCUS       NZ_FOYG01000001        27009 bp    DNA     linear   CON 22-AUG-2024
DEFINITION  Paenibacillus sp. cl130, whole genome shotgun sequence.
ACCESSION   NZ_FOYG01000001
VERSION     NZ_FOYG01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus sp. cl130
  ORGANISM  Paenibacillus sp. cl130
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900116035.1-RS_2024_08_22
            Annotation Date                   :: 08/22/2024 03:12:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,232
            CDSs (total)                      :: 5,132
            Genes (coding)                    :: 5,055
            CDSs (with protein)               :: 5,055
            Genes (RNA)                       :: 100
            rRNAs                             :: 7, 8, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 7 (5S)
            partial rRNAs                     :: 8, 5 (16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 40 of 77
            Pseudo Genes (incomplete)         :: 49 of 77
            Pseudo Genes (internal stop)      :: 13 of 77
            Pseudo Genes (multiple problems)  :: 20 of 77
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:52:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 737909
            Orig. end                         :: 764918
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOYG01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27009
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27009
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27009
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:17009]"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..17009
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(1305..2003)
                     /locus_tag="BM358_RS03465"
                     /old_locus_tag="SAMN04488603_101704"
     CDS             complement(1305..2003)
                     /NRPS_PKS="Domain: ACPS (103-161). E-value: 5.2e-12. Score:
                     37.7. Matches aSDomain:
                     nrpspksdomains_BM358_RS03465_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426685.1"
                     /locus_tag="BM358_RS03465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101704"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_028542930.1"
                     /transl_table=11
                     /translation="MKIYAIDTSKPEAEEHYELLVNRVSLEKQHKLDRFLHREDALRGL
                     YADVLLRWLVCRQLKVSNASLQFTYNAFGKPSLINAPAFHFNVSHSGKWVVCAIDDHPL
                     GIDIEQLRPIDFEVGRVCFSDKEYDALMRQDADNRLSYFYDLWTLKESFVKAEGQGLTL
                     PLKSFSFELKAQPFIGFTTEGFTTEYCHFKQYELDQDYKMAVCAAHDQFAQQVQQIDIN
                     TLRLEVATQA"
     aSDomain        complement(1521..1694)
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM358_RS03465_ACPS.1"
                     /evalue="5.20E-12"
                     /label="BM358_RS03465_ACPS.1"
                     /locus_tag="BM358_RS03465"
                     /protein_end="161"
                     /protein_start="103"
                     /score="37.7"
                     /tool="antismash"
                     /translation="LGIDIEQLRPIDFEVGRVCFSDKEYDALMRQDADNRLSYFYDLWT
                     LKESFVKAEGQGL"
     gene            2231..3697
                     /locus_tag="BM358_RS03470"
                     /old_locus_tag="SAMN04488603_101705"
     CDS             2231..3697
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686791.1"
                     /locus_tag="BM358_RS03470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101705"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_025723966.1"
                     /transl_table=11
                     /translation="MKYDFARLLCIMLSILLTLSIFQMFSPKIASAASANVVNGIQFKD
                     TDGNVVHAHGGGMIKVDGYYYWFGENRNPNGTFKAVSAYRSSDLKNWEFRKNVLTSSSA
                     VELNVSNIERPKVIYNEKTRKYVLWMHKENGVNYNEARVAVASSDTVDGDYTYQGSFRP
                     LDHDSRDMTVYNDNGTAYLISATRVNADLNIYRLTPDFLQVESLVTTLWPGQYREAPAM
                     FKKGDVYFLITSGATGWNPNQAKYATASSIEGTWSNTINFGDGTTYGSQSAYVIPVEGA
                     QTTSYLYLGDRWAGAWSGPVQDSQYVWLPLRFPTATSLAMDWFDSINIDTASGVVEGIT
                     TPIAIDPDAYYQLVNRKSNKPLSIIGNATTDGADLEQRANSGAANQQWQLKDAGSGYYK
                     IVNRNSGKLIGVESGTTTDGTVIEQWSDGGWSSQHWQLVSVTGGYYKLKNRATGKLIDI
                     SEGATADGAKAIQWGDNGGTNQHFRVVKVE"
     gene            complement(3806..4321)
                     /locus_tag="BM358_RS03475"
                     /old_locus_tag="SAMN04488603_101706"
     CDS             complement(3806..4321)
                     /EC_number="3.1.2.20"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280639.1"
                     /locus_tag="BM358_RS03475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101706"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_013309488.1"
                     /transl_table=11
                     /translation="MESKYIRETYCFKTSRVFPNDINNHNTLFGGRLMSYIDDIASIAA
                     AKLCRTNTVTASTDSVDFLLPIHPSDSVTLEAFVTWTGRSSMEVFVKVIREGLMTGDRK
                     IAATAFLTFVALDENNRKVTVPQVIPETEEQLQLHQTAPSRAAIRRQRREESKQLASFL
                     TTDYPWEL"
     gene            complement(4422..4970)
                     /locus_tag="BM358_RS03480"
                     /old_locus_tag="SAMN04488603_101707"
     CDS             complement(4422..4970)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007429618.1"
                     /locus_tag="BM358_RS03480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101707"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_023987843.1"
                     /transl_table=11
                     /translation="MDSMQHIIGSNLAQIRKTRGLSLDKVAELTGVSKGMLAQIEKGKS
                     NPTVTTLWKIANGLHVSFSTFLKEDPPQITKIRREDLHPVIDEDGNYFVYPVFPYHAEK
                     KFEVFTVSLKPGFTHQAEKHLGEETILMIRGEMYFEMQGQQLKLSAGDAVQFQVSDIHT
                     YRNDSDEDADFYVLIYYAD"
     gene            5384..6622
                     /locus_tag="BM358_RS03485"
                     /old_locus_tag="SAMN04488603_101708"
     CDS             5384..6622
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426681.1"
                     /locus_tag="BM358_RS03485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101708"
                     /product="sugar MFS transporter"
                     /protein_id="WP_028542931.1"
                     /transl_table=11
                     /translation="MNLQTRKSRHMYTMQLATIFIGFIVFGISENIKGPAIPRIQFDFN
                     LDEQQLGTLLSLNALGYLIACSFTAVLVRKWGIKAVSIISFASMIISGVFIYLSHTYPF
                     FASSYFLMYIGNGMLEIALAILGARIFVKNTGTMMNLSHFFYGLSSTVAPLLATGVMSL
                     TVFGHMLDWRGMYLAMLSLCLLPIVAALLSTFPGDDLQHEDRTSLKTLTRDPALWMMVM
                     ILSFGVVSELAVGGWLVNFLEKAYSWSTVEASSMLSAFFLTFSLGRLLLGPLTDRMGFV
                     LSTILFSAFSAICTFAAIAGGERLAFLFAVSGAGIAMIYPTVMAFIARRYPKDSDTAIT
                     FVVTLMGIGSVIGNYVIGWVIEGVKIVYGATTELGILRGLQAGYGVIGLCAAICAISGI
                     ILYGYLKKRQELI"
     gene            complement(6708..6869)
                     /locus_tag="BM358_RS26365"
     CDS             complement(6708..6869)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM358_RS26365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_155613661.1"
                     /transl_table=11
                     /translation="MYLPKRFGRVPVPDDLAAASHPKAVFKCTPDELFEMANGQELMMN
                     QSSSDVFI"
     misc_feature    complement(6991..7004)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.91"
                     /tool="antismash"
     gene            7024..7749
                     /locus_tag="BM358_RS03495"
                     /old_locus_tag="SAMN04488603_101709"
     CDS             7024..7749
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820470.1"
                     /locus_tag="BM358_RS03495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101709"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_028542932.1"
                     /transl_table=11
                     /translation="MSIASELSGTKHDSLSFLQGVKDCIPTLLGYVCIGFAAGIVGASS
                     GVSTMEIAFMSALVYAGASQFIMCSMLAAASPPSVIILTTFIVNARHLLLSASLAPYFS
                     KYSLWKNIGIGVLLTDESFGVASDKLAKGGQVSDRWMNGLNITAYLAWIASCVAGGVLG
                     NWISRPEAFGLDFALPAMFLALLISQLQSVQTSKLKHRLLLVLCMAVLMYLLSWWVPSH
                     IAVIVATMITATIGVLTDK"
     gene            7746..8069
                     /locus_tag="BM358_RS03500"
                     /old_locus_tag="SAMN04488603_101710"
     CDS             7746..8069
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820471.1"
                     /locus_tag="BM358_RS03500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101710"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_028542933.1"
                     /transl_table=11
                     /translation="MNINPNVLYIIIGAMIVTAIPRIIPFVVLQRLALPKPVLQWLSYI
                     PICIFTALVMENLLVRTETSVTLNGQVLMAVLPTLVTALWSKNLLATVVVGIVSMAVVR
                     LWW"
     gene            complement(8113..9894)
                     /locus_tag="BM358_RS03505"
                     /old_locus_tag="SAMN04488603_101711"
     CDS             complement(8113..9894)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309469.1"
                     /locus_tag="BM358_RS03505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101711"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_256253338.1"
                     /transl_table=11
                     /translation="MIAILITNLLKGAIPAVILLTTRELINSVVAGASGGSFQPVFIAF
                     GVLIGVNLLYDLINIGESFFRKMFQSRLSNQVNIRIIEKAQKMSLQSFEDADVQNMLQR
                     AQGEADFRPFEIFTQILAIISSVVTLFSTGAILIAWRWWAFLFIFLIPCLSFYSFLRIG
                     QREFNVHFQRAGRQRESWYLSFLVTRDNSFKEVKIFQLGDYLRKRYKTILEGFYREDKV
                     LAARRSYTSLVFQIVNQGACAFIIFMAIQATYVGQILVGNLVSLIQGITLTQSTSQSIV
                     QGILSLCQNNLYIKQLFDFLDMPEEAKIQKTVQQLPLSTIHSIEFRNVSFRYPNTEENA
                     ISNVSFKLHQGEKLAIVGRNGSGKSTIVKLLTHLYSDFEGEILINGHSIHELDKDSFRE
                     KIGVVFQDFVHYEMAVRDNIGFGNVASRENDEAIWTAIDKAGITDLIVGLPDKMNTLLG
                     KWFEDGQQLSGGQWQRIAIARAFMRNADIYVLDEPSSFLDPHAEKEVFQKFDQLIHEKI
                     GVFISHRLSSARMADTIILMEEGRIVEAGSHERLIDIDGVYAEMFRLQASSYLSQRERG
                     FEEENLSPSLVRTTGGS"
     gene            complement(10001..13255)
                     /locus_tag="BM358_RS03510"
                     /old_locus_tag="SAMN04488603_101712"
     CDS             complement(10001..13255)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820473.1"
                     /locus_tag="BM358_RS03510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101712"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_028542935.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8e-191, bitscore:
                     631.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 8.2e-16,
                     bitscore: 54.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.3e-54, bitscore:
                     179.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRQLHYTDAHKLHNEVRDRDERWFSACDFFLIRAPLLSLDRYFQ
                     VFSDQDVDSQLTLEEITRRLKLISQEAVVQEAIALASPSLMQFLHYLNDGHALDDKGEL
                     QKYEKTLNSFYRYFIRMTTRTTPFGLFSGVGQGICGKTTDLDIGSYPKHLKRARPDMEW
                     IYKLIQKIEADPAIFNQLKVFLNKTVMIKGNRAKLPFRPKHGAAEADDSAEIFNSIRLT
                     DVVRMTFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQEFILSELRPPLMDH
                     SPFHYIFEKIKKLDISDPWIHILHEIDTLLLQYNQCTIGEGEKVYRKLCDKMLDIISVK
                     TPVQVDVLLDKEVTLPKHVLDEVSLGAEVMCKLYASPKTDELAEYLNRFLEKYGVYQEV
                     PIHELFDEDWGLGIPEMYRSNEKKSMGMEAFKRNAVLFQWVSNAISNHEIELALTDEQL
                     EQLMISDNYDTSPESMEIYYSIFAESPEKVDSGDYSLLLGASAGSNRAGKTFGRFLDMF
                     SEEFVQKFSEIYDHHRCFHPDALLSEMVFMPEQGKISNISLSKNLMAYEIVSGTTSSKD
                     EDHTLCIDDLVVGATHDRFYVKSRRLGKEIIPLQTHMLNYKLSPHIFRFLTDITNKEIG
                     TWSYFDWGPLEQSPFLPRLVYKKIIISAAQWKLSKASLNISESCESKEGEELFHVWRQQ
                     WNVPRYVYLTMGDNRLLLDLCNLFHIKELLHEVSKTREGQELLLTECLGNPFHTPVQGT
                     AGRYMGEFVFPLKKKKIKVKPSIPSSQNHIVSQNFITHTPSSIHRGIFPGGEWLYLKLY
                     GVKERETDLVGLSLGHLLKQPGFKDWSRKFYFLRYVDPEHHIRLRFQGEPDKLWTAGLA
                     QLNQWAAELREEGLITNMVIDTYHPELERYGGQTLMELAEQVFDVDSQWVIAYMKGIRS
                     NAFNLDIEIAAVINIIHYLSGFGLTIQEQVKWLEERIDCKPHMKAFRDVKKTLITAVES
                     NYEWIGQADTNTQVAFLALVEKRQTMIQQYAQAIILAKNNHELTNPSDDILGSIIHMHL
                     NRLLGVNREREIKCMALAKHTVANLLHRKGVSYVTV"
     aSDomain        complement(12425..12709)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BM358_RS03510_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.90E-17"
                     /identifier="RREFam001.1"
                     /label="BM358_RS03510"
                     /locus_tag="BM358_RS03510"
                     /protein_end="277"
                     /protein_start="182"
                     /score="54.8"
                     /tool="antismash"
                     /translation="VFLNKTVMIKGNRAKLPFRPKHGAAEADDSAEIFNSIRLTDVVRM
                     TFEAAEHPIRVMELKEILLKAFPDATLEIIADYLQQLVEQEFILSELRPP"
     gene            complement(13230..13907)
                     /locus_tag="BM358_RS03515"
                     /old_locus_tag="SAMN04488603_101713"
     CDS             complement(13230..13907)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820474.1"
                     /locus_tag="BM358_RS03515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101713"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023987836.1"
                     /transl_table=11
                     /translation="MKQKFMVISSFRKIKHFFETLSTPENIRIMFYDSLYQALPEIDEQ
                     CIGVALNQDHITLEDLSYWHSIKEKFTVPFIFLSYHSDDQRQLDLLKQLFSMASSAYEM
                     EREQQAISLSPNVIFDPAGKVIWKQGHEHMLTMMEFRLLMYLLTAKECASTIDHIIDRV
                     WGVDAFTTSNTVYVHIRKLREKIEDDPSHPKILVTCHGIGYKLNIFPKNLEVVSCEETT
                     ALH"
     gene            complement(13958..15220)
                     /locus_tag="BM358_RS03520"
                     /old_locus_tag="SAMN04488603_101714"
     CDS             complement(13958..15220)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820475.1"
                     /locus_tag="BM358_RS03520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101714"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_023987835.1"
                     /sec_met_domain="LANC_like (E-value: 4.4e-59, bitscore:
                     196.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVEDLKGRSVEISKYIAQKLIDLSYTEKIVNHTNNLSPSRGNPPW
                     NPGSLADGIPGVFALLSEWGYLEPDQNWAEHVHSQLRYLDTNSLLLLPRISLYYGTTGV
                     AYGILLASNNRANYNKLISQLNKYIEVKWGDLPVIGTITEFSRQMDIINGLLGVGRYTL
                     EVAEDKTMCDLSRQLLDTITHFIPEYIHLSSREDSASIHLGLAHGITGILALLVTALQK
                     KIKVEGLHEAIKHIADFLLIQIQEDQYGWYWPVNSQASSMNKREKKVGMREIEGWCHGT
                     FGIAWTLFRAGIECSNEEWKKIAEKAMQSIFCLDDELLNALSPTFCHGLAGLLHMAHRF
                     YSLTGNIAALHFADQIALKLVNLYDEELPFGYRDLEGTTHVHNVGILQGATGIALSLLD
                     YGIGKEHPKYSGRWSELFLIS"
     gene            complement(15297..15449)
                     /locus_tag="BM358_RS03525"
                     /old_locus_tag="SAMN04488603_101715"
     CDS             complement(15297..15449)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820476.1"
                     /locus_tag="BM358_RS03525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101715"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_023987834.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.4e-05, bitscore:
                     21.2, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQFDLDLQVAKNEVAPKGVQPASGIICTPSCATGTLNCQVSLT
                     FCKTC"
     CDS_motif       complement(15378..15449)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNQFDLDLQVAKNEVAPKGVQPA"
                     /locus_tag="BM358_RS03525_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15297..15377)
                     /prepeptide="core"
                     /locus_tag="BM358_RS03525_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="5.90"
                     /molecular_weight="2508.0"
                     /monoisotopic_mass="2506.2"
                     /core_sequence="SGIICTPSCATGTLNCQVSLTFCKTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNQFDLDLQVAKNEVAPKGVQPA"
                     /leader_location="[15377:15449](-)"
                     /alternative_weights="2526.0"
                     /alternative_weights="2544.0"
                     /alternative_weights="2562.0"
     gene            15648..17009
                     /locus_tag="BM358_RS03530"
                     /old_locus_tag="SAMN04488603_101716"
     CDS             15648..17009
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309464.1"
                     /locus_tag="BM358_RS03530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101716"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_028542936.1"
                     /sec_met_domain="LANC_like (E-value: 2.8e-56, bitscore:
                     187.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDSFVIQQSDQVRARDISKKIALRLCEPESVYAAVHAEHNVSP
                     ETKYHPWGETSLSHGYPGNIHLLSQWRATDPSYDWNRAIHSNMAQIQSSLAKNGLHDLS
                     LYSGWAGIASSVREASNHGKYYSNFLQQIHQWMMPLTEQWLQSNTEKLSLHEGMPMQAF
                     DTISGASGIGRYILMNSTDPICTPLVEPILQFLTDLTHPIHIHNRYVPGWYSPQKFQFL
                     DRDKRNYPLGNFNCGMAHGIPGPLALLSVAYSAGIEVKGQYQAIETIAEWLLKYKYEDE
                     YGSYWPHIVPFEAETGSLRFDLERAREAWCYGTPGIACTLFLAGRALHNEELQKLAVKA
                     CVGAISYEIAKREMDSSALCHGLAGLLTISWRMWCHSKEPAFLPLIQQLTNCLLDRFQM
                     DSPLGYLDPEPRADGSLVWLTKAGMLEGVAGIAAALLSVSENKEIGWDYILMLS"
     gene            complement(17010..17744)
                     /locus_tag="BM358_RS03535"
                     /old_locus_tag="SAMN04488603_101717"
     CDS             complement(17010..17744)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370165.1"
                     /locus_tag="BM358_RS03535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101717"
                     /product="ABC transporter permease"
                     /protein_id="WP_013309463.1"
                     /transl_table=11
                     /translation="MGSILRVETIKLQWIMVWILIILDAIINSLMGVLELNDLKQFFSP
                     SWLTLYTYSAQFHSMFFYPLYCGIIASLLCAYEHRDGGWKILLSSPYPRQQIYYAKYIL
                     LILILGLDQLIFIVGYFVSGNIAGAPGEIPWSVVLSTGLGGWLGIFPLAALQLMLSIKI
                     RNFGASLGMSICCVVPNIVITGFHSSIGAWFPFTIPYYIMMPQTATYAPRVEPYSLGLI
                     VIFTFLAYLYGGRKMFVNRDWL"
     gene            complement(17759..18466)
                     /locus_tag="BM358_RS03540"
                     /old_locus_tag="SAMN04488603_101718"
     CDS             complement(17759..18466)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370164.1"
                     /locus_tag="BM358_RS03540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101718"
                     /product="ABC transporter permease"
                     /protein_id="WP_023987832.1"
                     /transl_table=11
                     /translation="MILRVIKAEGLKLKKICWWIPLIQGCVLTGMTAVEWYLYFRQGPG
                     GVYAGFAVMFMFLSFVMLLGGTLLASIMAGTEHDTQTWKQLMAMPVPRSYIYLSKIVWI
                     VILQLGTALITVAGMSLIWVLYTNEPIPWRIMLLQPINASLATLPVLAIQLWLSTLFTN
                     QAFPLAFGIFGSIASLFLARTSILWIKILPWSYPALSSPLMKEHMIWVIVALSAGVIFT
                     GLGTLQFTKHEFK"
     gene            complement(18463..19386)
                     /locus_tag="BM358_RS03545"
                     /old_locus_tag="SAMN04488603_101719"
     CDS             complement(18463..19386)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426675.1"
                     /locus_tag="BM358_RS03545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101719"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023987831.1"
                     /transl_table=11
                     /translation="MSEYVIHTQQLTRRFGKREFVKRINLQVPGQQIYGFLGPNGAGKT
                     TTIRMLLGLIKSTSGEIEIFGKKLKDQRMEILKDIGSLVESPAYYAHLSAYRNLEIVTT
                     MRGLPTRRIHEVLDLVRLTKDAYRPVKGYSLGMRQRLGIAMALIANPKLLILDEPTNGL
                     DPSGIQEIRELIMSLPGAYGMTVLVSSHLLSEIEQIATYVGIINQGEMIFQGTMKELTA
                     KSKPQLFIETPDPVLAAGALIQHGWTAGAESIEQNEVVTPIVDRQQSSEMIKVLVEHNH
                     PIYRVTEKKKTLEEIFLELTGKERSL"
     misc_feature    19423..19441
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.67"
                     /tool="antismash"
     gene            complement(19531..20601)
                     /locus_tag="BM358_RS03550"
                     /old_locus_tag="SAMN04488603_101720"
     CDS             complement(19531..20601)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686784.1"
                     /locus_tag="BM358_RS03550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101720"
                     /product="sensor histidine kinase KdpD"
                     /protein_id="WP_028542937.1"
                     /transl_table=11
                     /translation="MNSLVKMSFRFMKVTLCFVLAYVLCFVICTILYIFIKSIFGASQN
                     INIDLFWTGLGIVQSVVFIAAYGWYIGKPLVYVIKWIGNIATGEFQAPLSELELPEGKK
                     NQKNSYKPPYQLYKEVFEQMNILSAQLRSNEEERVEIEKRKQQWVAGVSHDLKTPLSYI
                     EGYAVMLTAQEYDWSDEERRSFSMGISEKVTEMKQLIQDLNASMQLKEGPLPIQLEKED
                     IVEFLRSAVIDIANHPSAEQYEFSFTSMDAACIMPFDSKLLGRALQNFLINAIIHNPPG
                     THVSMEVSKANDKLHISIEDDGIGMNSNEYMQVSHSQGHGIPIAKSFIEAHNGTLHILS
                     GSKAGTRMEISLPLNI"
     gene            complement(20598..21317)
                     /locus_tag="BM358_RS03555"
                     /old_locus_tag="SAMN04488603_101721"
     CDS             complement(20598..21317)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686783.1"
                     /locus_tag="BM358_RS03555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101721"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023987829.1"
                     /transl_table=11
                     /translation="MEEIAVLIVDDEQGLRDMLTTVLKKEGFLQVKHAATGREALQVVM
                     ESHVDVIVLDVMLPDNDGFEVCRQMRLYTDAPILFLTARDTDLDKLMGFGIGGDDYITK
                     PFNPLEVVARMKARMKYRKVSTVAMKPTLRTLDFGYFRLELESGVLYVEDKQVDCPARE
                     WLLLVFLCKHPNRIFSVRQLYEAIWSEAFLGDEKTVVIHISRLRKKIEPDPKHPQFLIN
                     VRGLGYKMMSVKMEEQE"
     gene            21482..22648
                     /gene="yhbH"
                     /locus_tag="BM358_RS03560"
                     /old_locus_tag="SAMN04488603_101722"
     CDS             21482..22648
                     /GO_process="GO:0030436 - asexual sporulation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yhbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370159.1"
                     /locus_tag="BM358_RS03560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101722"
                     /product="sporulation protein YhbH"
                     /protein_id="WP_023987828.1"
                     /transl_table=11
                     /translation="MPEPRQPYSFVVSREDWSLHRKGYQDQQRHQQKVKDVIKQNLPDL
                     ITEENIIMSDGQQIIKVPIRSLDEYRFIYNYQKQKHVGQGDGDSQVGDVIGRDPASQKP
                     GKGEKAGDQPGHDIMETEVSIEELEDMLFEEMELPNLQQKDKDQIEVESIVFNDIRKKG
                     MQANIDKKRTILENLRRNAREGKPGIHHISPDDLRYKTWEEKTIPQSNAVIIAMMDTSG
                     SMGSFEKYCARSFFFWMTRFLRRQYEKVEIVFLAHHTEAKEVTEEEFFTRGESGGTICS
                     SAYLKALEIIDKRYPPSSYNIYPFHFSDGDNLTSDNERCVKLIEELIKRSNMFGYGEVN
                     QYNRSSTLMSAYKNIKKDQFMYYVIKEKGEVYQALRTFFRKREGGSVG"
     gene            22645..24087
                     /locus_tag="BM358_RS03565"
                     /old_locus_tag="SAMN04488603_101723"
     CDS             22645..24087
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013309457.1"
                     /locus_tag="BM358_RS03565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101723"
                     /product="SpoVR family protein"
                     /protein_id="WP_028542938.1"
                     /transl_table=11
                     /translation="MSTDQKELEYAISEIMEIADGFGLDYYPMRYEICPADIVYTFGAY
                     GMPTRFSHWSFGKTFHKMKMQYDFGLSKIYELVINSNPCYAFLLEGNSLVQNKLIVAHV
                     LAHCDFFKHNARFSASNRNMVESMSATADRINSYEMEYGSKAVESFIDSVLAIQEHVDP
                     QIIKPRHLDKQRYMELKIREQKEPGKRQRPPGPYDDLWSLDTVKQHNPAETEGIKIRQF
                     PPEPEKDIVWFIQEFSEVLEDWQRDIMTMLRDEMLYFWPQMETKIMNEGWASYWHQRIV
                     RELDLTGEETVEFAMLNASVVQPSKQSLNPYYLGLKIFEDIEKRWDNPTREEQERQGRK
                     PGEGRAKMFEVREFDSDTSFIRNYMTKKLTEDLDLYVFEKRGPDWKITDKSWENIRDQL
                     VFSRVNGGSPYIVVEDGDYLHTGELKLKHQYEGIELDLKYMERTLPYVYQLWGRTVHLE
                     TLIEGKLALFSYDGKKHHRKFV"
     gene            24303..25334
                     /locus_tag="BM358_RS03570"
                     /old_locus_tag="SAMN04488603_101724"
     CDS             24303..25334
                     /EC_number="1.14.13.-"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014649242.1"
                     /locus_tag="BM358_RS03570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101724"
                     /product="aromatic ring-hydroxylating dioxygenase subunit
                     alpha"
                     /protein_id="WP_028542939.1"
                     /transl_table=11
                     /translation="MNTHPSFREVRESDQQVFPIAWYAVGWSKELKNKPLKKRLLGKDI
                     VLYRDDHRQVHAIHAYCPHRGADLSLGYCQSGHITCPYHAWSFDESGQCVDIPAHPGRA
                     IPEFAHTYAYPAIEKAGLLWVYPQAVGSKSEINSEMGTSTSPPPLEIFPELEDPSLILS
                     PYDSVWKAHLTRVVESVLDVAHLPIVHNKTIGKKSSTDIHIEFEADDNHIRVKNGKGLL
                     QYTFPQQWILTPVKEGRSKFINFVTFTPIEQELTAIYGMAGRNFARFVPGMSHIFSRYS
                     GKVLEEDRAVVESQHPRPIPEALRMEAHVPADGPQVRFRNRWYDFLVNDEPRVRLGPET
                     TSS"
     gene            complement(25321..26502)
                     /locus_tag="BM358_RS03575"
                     /old_locus_tag="SAMN04488603_101725"
     CDS             complement(25321..26502)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016820485.1"
                     /locus_tag="BM358_RS03575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488603_101725"
                     /product="PD40 domain-containing protein"
                     /protein_id="WP_023987825.1"
                     /transl_table=11
                     /translation="MIKKNIGSYGQKNGSSHREDSRTRVFRQKATGVLMAGLIAGGLFS
                     GCGIKSAGETNPASGMKPGQQLTVIDTDAAQQQVTDELVVSSIDRLGDVYARSWLSDEE
                     LIVERKTQLWIHNVETDKERILTPGRKAPQLLAVVSPDQRHVFFTEGSTSSKYDIQGYI
                     LELSSGKVTSIGKLDMTNEVSWSDENDLITGTPDGKIQLIGLDGKAKELSFQDPNRSEL
                     MSHVEKVGNAIFYTGSDKQGYPVLNRFTLNHPQAVTIAEGAMSFAVSPDGKSIAIEKRK
                     WNTSEPARMIILDEQGKEKGIVGQGTLMSRGSWSSDGSKLAYSIYDEDQQGMRGLYVFD
                     QSTGKTTPVTTDIQSYDSPTVWSPSARFLSMYQNISEGGKQLNQSYIVEFKRK"
ORIGIN
        1 gcttccaaca gctttttcca ggcatataaa tattcagtcc gttctttccc cacccgatcc
       61 agtacccaag ggaagtcact tgcgacaaaa cggggctgga tgtccgcaat cagcggcagc
      121 ttcgccattc tcttgaccaa atccctccta agcacctgtc catggatcag gcgatctggc
      181 aaaccgcttt cctccgtgag cacatgggcc tccatcgctg tcaaaatcat gtgcgctgcc
      241 ccatccccta tagcatgtac agccactgga aagcctgcgg ccctggcagc tgccaccatc
      301 tgattcagct ctggctgcgg ttgaatcgcc attccgcggg tatgtggagc atcactataa
      361 ggttctgaca ataatgccgt tcttccacca atagcgccat cggcaaacat tttaatcgca
      421 ccgattttaa accactcatt tccggtacct gcacgcagcc cttgcacttt cgcttcttcc
      481 ataaagggat gatagatgag ctggtgtgtg cgaaaagcaa gaccttcttc cctcagctcc
      541 ctgtaaattc gctgcatcgt ctccacgctg cccaaaaaac gtaaatcttc cgtgtgcgca
      601 gcagttagac caagccgtag cgcatccagg caagcccgcc gaatcgtatc cttcttaacc
      661 gaataatccg gctctggctg cacgctagta aaggcaaagg atgcttcctc ataaatcaat
      721 ccgttcaacc gtccatgtgc gtctcgtcca taggctcccg aagccgggtc aggggtgtcc
      781 tcgctaatac ccgcacgccg aaatgcctct gaattggcca agaacgtatg aaagcacgta
      841 cgagtgagat ataccggatg ctgatctgta atggcatcca gctcggctat acccggaatt
      901 tcaacaggaa taaacgcatt ttcattccag ttaagtccta aaatccactc tcccggcggt
      961 gttacagcga cccgtttgcg cagcatagcc agcatctctt ccttggaggt agctgatgtt
     1021 aaatccagca tagccagctt cataccatgc atagacaaat gcatatgtga atcggttaag
     1081 cctggcagta cataggcgtc ttcccaatcc acagtttcat attccttacc ggtcaactgc
     1141 aattcaagct cccgagcata tccgatggct tgtatccgac cctgctgtac aacgatggag
     1201 tctcctttgg aagcccaatc cccatgcaac cggccgtgct tgaacaaaac gaatgtcaac
     1261 gccactcatc tccttttttc aactatacgc atatccactt catattacgc ctgtgttgcc
     1321 acttccaagc gtagtgtatt tatatctatc tgctgcacct gctgggcaaa ttggtcatga
     1381 gctgcacaga cagccatttt ataatcctga tccaactcat actgcttaaa atgacaatac
     1441 tcggtggtaa agccctctgt cgtgaagcct atgaacggtt gtgccttcag ttcgaatgaa
     1501 aaagacttca acggtagagt tagtccctgc ccctcggcct tcacaaagct ttctttaagc
     1561 gtccatagat cgtaaaaata ggacaatcgg ttgtctgcgt cctgacgcat taacgcatca
     1621 tactctttgt ccgaaaagca cactctacct acctcaaaat caataggacg gagctgttca
     1681 atgtcgattc caagcgggtg atcatcaata gcgcacacca cccattttcc cgagtgagaa
     1741 acattaaaat ggaatgcggg tgcatttatc aaggaaggct taccgaacgc attgtatgta
     1801 aattgaagac tagcattaga taccttcaat tgccggcaga ccaaccatct tagcagcaca
     1861 tcggcatata agcccctcaa agcatcttcc cgatgtaaaa aacgatctaa cttgtgctgc
     1921 ttttccagcg aaacccgatt taccagtaat tcgtaatgct cctcagcttc cggcttgctc
     1981 gtatcaatcg cgtatatttt catggttgcc tcctgtatat ctaatgaata tcagccagtt
     2041 tgtaacactc accgttcgat tgaagtctgt tagatatgga tggcgtgtgc cgtgtacatg
     2101 gtcaatatac tactctagca ctttcaattc aatatggata caattgggat aagcatctct
     2161 attaaaacta cttcatagag cctattaatg aaagcgcttt aaaataacgc atgcagagga
     2221 ggacgaaaca atgaaatatg attttgcccg cttgctgtgt attatgctct ctattttgct
     2281 gacgttgagc atttttcaga tgttttcacc taagatcgct tcagccgctt cagcgaatgt
     2341 tgtgaatggc attcagttta aagatacaga tggaaacgtg gtccatgccc atgggggtgg
     2401 tatgattaaa gtagacggtt actattattg gtttggtgaa aatcgtaatc ccaacggcac
     2461 gttcaaggcg gtatccgcct accgttcctc tgatttaaaa aactgggagt ttcgtaaaaa
     2521 cgtactaacc agcagctccg ctgtagagct gaatgtttcg aatattgaac gtccgaaagt
     2581 gatttacaat gaaaaaacac gtaaatacgt attatggatg cataaggaga atggggttaa
     2641 ttacaacgag gcccgagtgg ctgtcgcttc ttccgatacc gtggacggcg attacacgta
     2701 tcagggcagc ttccgtcctc tggatcacga ttcgcgcgat atgaccgtat acaacgataa
     2761 cggtacagct tacctcattt cggctacccg ggtaaacgcg gatctgaaca tctatcgtct
     2821 gacaccggat tttctgcaag ttgaatcgct ggtgactaca ctttggccag gacaatatcg
     2881 tgaagctccg gcgatgttca aaaaaggaga cgtctacttc ctgattacat ccggggcaac
     2941 cggctggaat cccaatcaag ccaagtatgc taccgcatcc agcattgaag gaacctggag
     3001 taatacgata aacttcgggg acggtacgac atatggttca cagtcggctt acgtgattcc
     3061 tgttgaaggt gcccagacaa cttcatacct gtatttgggc gaccgttggg cgggtgcgtg
     3121 gagcggtcct gtgcaggatt ctcaatatgt atggctgcca ctgcgttttc caacagcgac
     3181 ttcattagcc atggattggt tcgacagcat taatattgac accgccagtg gtgtggtcga
     3241 ggggataaca acgccaattg ccattgatcc ggatgcctat tatcagctag tgaatcgcaa
     3301 gagcaataag ccactaagca ttattggcaa tgcaacgacg gacggcgcag acctggagca
     3361 gcgtgcaaat tccggagctg caaaccagca atggcagctc aaggatgcag gcagcggata
     3421 ttataaaatt gtgaaccgca acagcggaaa gctaattggt gttgaaagcg gtaccacaac
     3481 agacggtaca gttattgagc agtggagtga cggaggctgg tccagtcagc attggcaatt
     3541 agtatccgta accggtggtt attacaagct gaaaaatcgg gcaaccggca agctgatcga
     3601 tatttctgaa ggcgccaccg ccgatggagc caaagccatt caatggggcg ataatggtgg
     3661 gacgaatcag catttccgtg tagttaaagt agaatagctc aagttatttt caaaaggagc
     3721 cgtattccga gcagacatgg tgactgctaa cggaaaagac ggctcctttt tacgtaaaac
     3781 gatgaaattg ataatctcta gtacgttaca attcccacgg ataatctgtt gtcaaaaaac
     3841 tagccaactg tttgctttct tccctccgct gacgccgtat ggctgcgcgt gatggagccg
     3901 tctggtgcaa ttgtaactgc tcttctgttt ctggaatcac ctgcgggaca gtcaccttac
     3961 ggttgttctc gtccaatgcc acaaaggtca gaaaggcggt ggctgcgatt tttcggtcac
     4021 cagtcatcag tccttcacga attaccttta cgaacacctc catcgagcta cggcctgtcc
     4081 aggttacgaa cgcttctaga gtgacagaat cactcggatg gataggtagc aaaaaatcca
     4141 ccgaatccgt agaggctgta actgtgttcg tacgacacag cttagcagct gcaatagatg
     4201 cgatatcgtc gatatacgac attaatcggc cgccgaagag cgtgttatga ttgttgatat
     4261 cgttgggaaa tactcgggac gtcttgaagc agtaggtttc tcggatgtac ttgctttcca
     4321 tggattcttt cctctctttt cctcgttgct ctctttttat atctcaggat tttgcaaaat
     4381 catgatgtgg aagcctgttt tagactatgc taatcatccc actaatccgc ataataaatc
     4441 aatacataaa aatcggcatc ctcatccgaa tcattccggt aggtatgtat gtcagatact
     4501 tgaaattgca cggcatcccc tgcactcagc ttgagctgtt gcccctgcat ttcaaagtac
     4561 atttccccac ggatcatgag aatcgtttcc tcccccaaat gcttctctgc ctggtgtgta
     4621 aaacctggct tcagacttac cgtgaacacc tcaaacttct tttcagcgtg atacgggaat
     4681 acagggtaaa caaaatagtt accgtcctca tcaataaccg gatgcaggtc ttccctccga
     4741 atcttcgtga tttgcggcgg atcttctttg agaaaggtgg agaaggatac atgcaaaccg
     4801 ttcgcaattt tccaaagggt tgttaccgta ggattggatt tccccttctc aatctgagcc
     4861 agcatccctt tgctgacccc tgtcagttca gccaccttat ccaaacttaa tcctctagtc
     4921 ttcctgattt gagccaaatt agagccaata atatgctgca ttgaatccac ggacgatgcc
     4981 tccttgtatc caaaagtcta tataagaaga atacacaaaa gactgtgtgt tcgctatata
     5041 tagactgtat cgtaaaatat catttatctt ttgcaatttt ggatgcatga cttattatcc
     5101 acagtaaatt aagtgtagcc gatcaaggta atacaaagct taaacgggaa gtagacatgc
     5161 tacaatttac tgtaattgta atatggtcag gttcctcgct tacttcaaca tgcaataaaa
     5221 acatttgaca ttgaatataa atgtccttaa acttttcact tattaaaact tttttcaaaa
     5281 ctattgtaat atcctgaagg agggctgcta tcctatgact tttccgtccc tgaacaccca
     5341 acaggtgaga aaatcaagtt tggctatcta ggagggacta aatttgaatc tgcaaacccg
     5401 caagtcccgc cacatgtata cgatgcagct ggcgacaatt tttattggct ttattgtatt
     5461 tggcatctcg gaaaatatta aaggccctgc cattccacgc atccaattcg acttcaatct
     5521 ggatgaacag cagctcggaa cattgttgtc tctaaacgca cttggttatt tgattgcctg
     5581 ctcgttcacc gctgtccttg tccgtaagtg gggaatcaag gcggtcagca tcatttcctt
     5641 tgcttccatg atcatctcgg gagtgttcat ctatctgtcg cacacgtatc cgttcttcgc
     5701 ctcgtcctac ttcttgatgt atatcgggaa cggcatgctg gagattgcgc tcgcaatttt
     5761 gggggcgagg atttttgtga aaaataccgg cacgatgatg aatttgtccc actttttcta
     5821 tgggctcagc tcaacagtcg cccctttgct ggcgacggga gtcatgtcac tgacggtatt
     5881 tggacatatg ctggactggc gggggatgta tctggctatg ttgtcgctct gcttgctgcc
     5941 gattgtggcc gcactgctca gcaccttccc gggagacgat ttgcagcatg aggatcgaac
     6001 ctcactcaag acgctaaccc gcgatccagc actctggatg atggtaatga tcctgtcgtt
     6061 tggagtagtc tctgagctcg cagttggggg ctggctggtc aactttttag agaaagcgta
     6121 ttcatggagc acggtggagg cgtccagcat gctctcagcg ttctttctta ccttctcgtt
     6181 ggggcgccta ttgcttggtc cactcacaga ccggatgggg ttcgtgcttt cgacgattct
     6241 attctccgcc ttctcagcga tatgtacgtt cgcagcaatc gcgggtggag agagactggc
     6301 gtttctcttt gccgtatcag gtgcaggtat tgcaatgatc tatccgaccg tgatggcgtt
     6361 catagcaagg agatatccga aggacagtga tacagctatt acgttcgtcg tcacgctgat
     6421 gggcataggt agtgtcattg gcaactatgt gatcggctgg gtaatcgaag gggtcaagat
     6481 agtctacggc gcaaccactg agcttggcat actgcgcgga cttcaggcgg gatatggagt
     6541 tatcggtcta tgcgcagcca tctgcgcgat ctcgggaatt attctctacg gatatctgaa
     6601 aaagcggcag gagcttatat aaatcaccac cttagggttg ccccataagt catgaactga
     6661 ctgggacgcc ctttttttac gagttcccca ttcagtcaaa acagccctta tatgaacaca
     6721 tccgagctgc tttgattcat catcagttct tgcccgtttg ccatttcgaa gagctcatcg
     6781 ggagtacatt tgaacaccgc ttttggatga ctggctgctg ccaaatcgtc tggaaccgga
     6841 acacgaccga acctttttgg taaatacata gccttcattg ggttgtcaac agtaaaacag
     6901 ctttttaaga gcaattctcc tgtaggaact attcaacata acatacaaac gtataatata
     6961 ttgatacttt acaacttacg ttatatacta ttataaaatt tatacactgg gggtaaggtt
     7021 aaaatgtcca tagcttcgga gttgagcgga acgaagcacg attcactcag ctttttacaa
     7081 ggggttaaag attgtattcc tacattgctc ggttatgtat gtattgggtt cgcggcaggc
     7141 attgtgggcg cttcatcagg ggttagcacc atggaaattg ccttcatgtc ggcgcttgta
     7201 tacgcaggag cctcccagtt tatcatgtgc tcgatgctgg ctgcagccag tcctccatcc
     7261 gtcattattt taacgacttt cattgtgaat gctcgtcatc tgctgttaag tgcgtcgctg
     7321 gctccttact tttctaaata ttcattgtgg aaaaacatag gcatcggtgt tcttttgacg
     7381 gacgaatcct ttggagtagc gtcggataaa ttggctaaag gcgggcaggt cagtgaccgc
     7441 tggatgaacg ggcttaatat tacagcttat ctcgcctgga ttgcatcctg tgtagcggga
     7501 ggggttctcg ggaactggat ttcccggccg gaggcttttg gtctggactt tgccttgcca
     7561 gcgatgtttc ttgccctgct catttcccaa ctccaaagtg tccagacctc caaactcaag
     7621 catcgtctgc tgcttgtgct gtgtatggct gttctgatgt acctattgtc ctggtgggta
     7681 ccatcacata tcgccgtcat tgtagcgacc atgatcaccg caacgattgg agtgttaacc
     7741 gacaaatgaa cattaatccc aatgtcctgt atatcattat cggtgccatg attgtcacgg
     7801 cgattccaag gatcattccc tttgtcgtgc tgcaaaggct ggcgctgccc aagccagtgc
     7861 tacaatggct ttcctatatt cccatctgca tattcacggc cctcgtgatg gaaaatttgc
     7921 tcgttcgaac cgaaacctcc gtcactctta atgggcaagt gcttatggct gttcttccta
     7981 cgctagtgac cgccttgtgg agcaaaaacc tgctggctac cgtcgttgtc ggtattgtga
     8041 gtatggctgt agttcgactt tggtggtaaa gataaaaata ccctcctaca ataggagggc
     8101 atctgccatt tcttatgatc cacctgtcgt tcttactaac gagggcgaca gattttcttc
     8161 ctcaaaacca cgttctcgtt gtgaaagata cgaggaggct tggagcctga acatttctgc
     8221 atacactccg tctatatcta ttaagcgttc atggctacct gcttctacaa ttctgccctc
     8281 ctccattaaa ataatggtat cggccatacg tgcagaggac aatctgtgtg aaataaacac
     8341 tccaattttc tcatgaataa gctgatcaaa cttttgaaaa acctctttct ccgcgtgtgg
     8401 atccaaaaaa gagctcggtt catccaagac atatatatcg gcatttctca taaaggccct
     8461 ggctattgca atacgctgcc actgtcctcc agatagctgc tgtccatctt caaaccattt
     8521 tccaagcaag gtattcattt tatcaggcag gccgactatc aaatctgtaa tccccgcctt
     8581 atctatagct gtccaaatgg cctcatcatt ttctctggaa gccacattac caaagccaat
     8641 attatctcta acagccatct cataatggac aaaatcctga aaaacaacgc ctatcttttc
     8701 tctaaaactg tctttatcca attcatgtat tgagtgtcca ttaattaaga tttctccttc
     8761 aaaatcggaa tacaaatgag tcagtaactt cacaatcgtt gatttacccg atccatttct
     8821 ccctacaatg gccagcttct ctccttgatg aagcttgaag ctaacattag aaatggcatt
     8881 ctcctccgtg ttcggatatc taaacgatac attccgaaat tcaatactgt gaatagtgga
     8941 caaaggcaat tgctgaaccg ttttttgtat ttttgcctct tccggcatat ccaaaaagtc
     9001 aaatagctgc ttgatgtaca aattattttg acacaagctt aaaatccctt gtacaatgct
     9061 ctgcgatgtt gactgggtta acgtgatacc ctgaattaag ctcaccaagt tccccactaa
     9121 aatttgacca acataagtgg cttgtatggc catgaaaata ataaatgcac acgcaccctg
     9181 atttacaatc tgaaatacaa gagaggtata ggatctacga gccgctagca ctttatcctc
     9241 gcgataaaac ccttcgagta tcgttttata tctttttcgc aaatagtctc ccagttgaaa
     9301 tattttcact tctttaaaac tattatctct tgtcactaaa aacgacaaat accaggattc
     9361 acgttgtctt cctgctcttt gaaagtgaac attaaattct ctttgcccga tacgtaaaaa
     9421 agaataaaat gataagcatg gaatgagaaa aatgaataag aatgcccacc atctccatgc
     9481 gatgagaata gcacccgtcg aaaataaggt tacaacactg ctaataatgg caaggatttg
     9541 agtaaatatt tcaaacggcc taaaatctgc ctctccctga gcacgttgga gcatattttg
     9601 cacatctgca tcctcaaacg actgcaaaga catcttttgt gctttttcaa taattctgat
     9661 atttacctgg ttcgatagcc ggctttgaaa cattttacga aaaaagcttt cgccaatatt
     9721 gatcagatcg tacagcaaat tgacaccgat caagacgcca aaagctataa aaacaggttg
     9781 aaagctgccc cctgacgctc cggccacgac actgttgatt aattctctcg tggttaaaag
     9841 gatcacagca ggaattgcac ctttcaataa attcgtaatg agtatagcaa tcaaaaagga
     9901 aggatgtgtg tcccaaagca gcctgaatat acgaggccaa aataaaaagg tacgaaatat
     9961 atttttatag gacaaagaga tcaggtcatt ggtttgtcca ttagactgtg acatagctta
    10021 cccctttcct atgcaacagg ttagctactg tatgcttagc taaagccata cattttattt
    10081 ctcgctccct atttacacca agcagacgat tcaaatgcat atgaatgatg ctgcctaaaa
    10141 tatcatcaga aggattggta agttcgtgat tatttttagc caggattatc gcttgagcat
    10201 actgctgaat catagtctgt cttttttcta caagcgctaa gaaagcaacc tgtgtgttcg
    10261 tatctgcttg tccaatccat tcataattcg attctacagc ggtaatcaat gtttttttga
    10321 catccctgaa cgccttcata tgaggcttgc aatcaattct ctcttctagc catttcactt
    10381 gctcctgaat cgttaaacca aaaccactca gataatgaat aatgttaatc acagccgcaa
    10441 tctctatgtc cagattgaaa gcattagagc gaattccctt catataggcg atgacccatt
    10501 gactatccac gtcaaaaacc tgttctgcca gctccataag tgtctgtcct ccatacctct
    10561 ccaattcagg atggtatgta tctatgacca tattcgttat tagcccctct tcacgtaact
    10621 cggctgccca ctgatttaat tgcgccaaac cagctgtcca tagcttatcg ggctctccct
    10681 gaaaacgtaa acggatatga tgttcaggat caacgtatcg caaaaagtaa aattttcgac
    10741 tccaatcctt aaaccccggc tgttttaaga gatgccctag gcttaagcct accaggtcag
    10801 tctctctttc cttgactccg tacaatttaa ggtatagcca ctcccctcct ggaaatatgc
    10861 ctctatgaat gctggaagga gtatgagtaa tgaagttttg agaaacaata tggttttgtg
    10921 aactagggat actcggtttc acctttattt ttttcttctt tagtggaaac acaaattctc
    10981 ccatatatct tcctgccgtc ccctgtactg gggtatggaa gggattaccc aaacactcgg
    11041 taagaagaag ttcctgtcct tcacgtgtct tgctcacctc atgtagcaat tctttgatat
    11101 ggaagaggtt acataggtct aataaaaggc gattatcccc catcgttaga taaacatagc
    11161 gcggtacatt ccattgttgt ctccacacat ggaaaagttc ttctccttct ttggactcgc
    11221 atgattctga aatattcaat gaagctttgc tcagtttcca ctgcgcagca ctaataatga
    11281 tctttttata tactagtctt ggcaaaaaag gggattgctc taatggcccc cagtcaaaat
    11341 aagaccacgt accaatctct ttattggtaa tatccgttag aaatctgaat atatgtggtg
    11401 aaagcttgta attcagcatg tgtgtttgca aggggattat ttccttaccc aaacgtctgg
    11461 acttgacata aaaacgatca tgagtagcac ccaccactaa atcatcaata cagagcgtat
    11521 ggtcctcatc tttagaagag gtggttcccg acacaatctc atatgccatt aaatttttgc
    11581 ttaatgagat atttgatatt ttcccctgtt ccggcataaa aaccatctct gacaataacg
    11641 catcgggatg aaagcatcgg tgatgatcat atatttcaga gaatttttgt acaaactcct
    11701 cactaaacat atccagaaaa cgtccaaagg ttttacccgc tctattcgag ccagcactgg
    11761 ctccaagtaa aagcgaatag tctccagaat caactttttc aggagactca gcaaatatac
    11821 tgtaatagat ctccattgat tctggggaag tgtcgtagtt atcagaaatc atcagttgct
    11881 ctaactgttc atctgtaagg gcgagttcta tttcatgatt agaaatggca ttcgaaaccc
    11941 attgaaaaag aacagcgttg cgtttaaatg cctccatgcc cattgatttt ttttcatttg
    12001 aacgatacat ttccggtata cccagacccc aatcctcatc aaacagttca tgaataggaa
    12061 cctcctgata cacaccgtac ttttccaaga aacgattcaa atattcagcc aattcatccg
    12121 ttttggggga tgcatacaat ttgcacatga cttcagcccc taatgaaacc tcatcaagca
    12181 catgtttcgg cagcgttact tctttatcca aaagaacatc aacttgtaca ggtgttttta
    12241 cagaaatgat atccagcatt ttgtcacata atttccggta gaccttctct ccttctccaa
    12301 tcgtgcattg attatattga agtaataaag tatcaatttc gtgtaaaatg tgaatccaag
    12361 gatcggaaat gtccagtttt ttaatttttt cgaatatgta atgaaagggt gaatgatcca
    12421 ttaacggagg tctaagctcg ctcaaaataa actcttgctc tactagttgc tgcaaataat
    12481 cagctatgat ttccaaagta gcgtcaggga atgcctttaa tagtatttct ttcagttcca
    12541 tcacccgaat tggatgttcc gcagcttcaa acgtcattcg aacaacgtca gtaagccgaa
    12601 tggaattaaa aatttctgcc gaatcatcag cttctgctgc tccatgctta ggtcgaaatg
    12661 gtaatttggc tcgatttcct ttgatcataa ccgttttgtt taggaaaacc tttagttgat
    12721 taaatatggc cggatcagct tctatttttt gaatcagttt atatatccat tccatgtcgg
    12781 gtctggctct cttcagatgc ttaggatagc taccaatatc cagatcggtg gtcttcccgc
    12841 aaatcccctg ccccactcct gaaaataacc caaatggagt cgttcgggta gtcatccgaa
    12901 taaaataacg ataaaagctg ttcagcgtct tctcatactt ctgtagctct cctttatcat
    12961 ccaaagcatg accatcattc aagtaatgta aaaactgcat tagggacgga gaggctaatg
    13021 ctatggcttc ttgaacaaca gcttcttggg atatcaactt taatcgacga gttatttcct
    13081 ccaaagtaag ctggctgtcc acatcttgat ccgaaaacac ctgaaaatat cggtctagcg
    13141 atagtaatgg agctctgatt agaaaaaaat cacatgcact aaaccatctt tcatcccgat
    13201 ctctcacttc attatgtagt ttatgcgcat cagtgtaatg cagttgtctc ttcacaactg
    13261 accacctcca agtttttagg aaatatattc aacttgtaac cgattccatg acatgttacc
    13321 agaatttttg gatgacttgg atcatcttct attttctctc tcaattttcg aatgtgcaca
    13381 tacaccgtat tagacgtagt aaaagcatcc actccccaga ctctgtctat aatgtgatca
    13441 atcgtagaag cacactcttt tgcagtaaga agatacatta ataatcggaa ttccatcata
    13501 gtcagcatat gctcatgccc ttgcttccaa ataacctttc cagcaggatc aaaaatgaca
    13561 ttaggtgata aactaatagc ctgctgttct ctttccattt catatgcaga tgaagccatt
    13621 gaaaacagtt gtttgaggag atccaattgc cgttggtcat cactatgata ggaaagaaag
    13681 ataaatggaa ctgtaaattt ttctttaatg ctgtgccagt aagacaagtc ctctagcgtt
    13741 atatgatcct gattcaaagc tacaccgata cactgctcat caatctccgg tagagcctgg
    13801 taaagcgaat cataaaacat gattcgaatg ttttctggag tgcttaaagt ctcaaaaaaa
    13861 tgcttaatct tcctaaaaga tgatataacc ataaattttt gtttcatcta atccccccaa
    13921 aaccaatgct tcagataagc aataaggtag agcgccctta agaaattaga aacaattcac
    13981 tccatctccc tgaatattta ggatgttctt tcccaattcc atagtccagc aaacttaacg
    14041 caatccctgt tgctccttgc agtattccta cattatgaac atgagttgtc ccctccaaat
    14101 cccggtatcc aaatgggagc tcttcatcgt ataaatttac taactttaaa gctatctgat
    14161 cggcaaagtg taaggctgct atattaccgg ttaagctata gaatctatga gccatatgaa
    14221 gcaaaccagc caacccgtga cagaaagtag gggatagcgc gtttagtagc tcatcatcta
    14281 agcaaaatat ggattgcata gctttttccg ctatcttttt ccattcttca ttactgcact
    14341 caattcctgc tctgaataat gtccaagcta ttccaaaggt tccatgacac cagccttcaa
    14401 tttctctcat ccctactttt ttctctctct tgttcattga agacgcttga gagtttacag
    14461 gccaatacca gccatattga tcctcctgaa tttgaataag caaaaaatca gctatatgtt
    14521 ttatagcctc atgtagtcct tcaactttga tctttttttg tagggcagtg acaagcagtg
    14581 caagtattcc ggtgatacca tgcgccaaac ctagatggat tgaagccgaa tcttcccttg
    14641 acgacaaatg tatatattca ggtataaagt gcgtaatggt gtctaataat tgacgagaca
    14701 gatcacacat cgtcttgtct tcagcaacct ccagagtgta tctgcccact ccgagcagcc
    14761 cattgatgat atccatttgc ctactgaact ctgtaattgt gccaattaca ggtaaatccc
    14821 cccactttac ttcaatatac ttattaagct gagagattag tttgttataa ttagctctgt
    14881 tattggaagc taataatatg ccataagcta ctcctgttgt tccataataa agagaaatac
    14941 gaggcaataa taatagagag ttagtatcta agtatcgtaa ctgactatgc acatgctctg
    15001 cccaattttg atctggctcc aggtaacccc attcggacaa cagcgcaaac acacccggaa
    15061 ttccatcggc aagcgagcca ggattccaag ggggatttcc acgtgaaggt gaaaggttgt
    15121 ttgtatgatt aactatcttt tctgtatatg ataggtctat tagcttttgt gctatatact
    15181 tactgatttc aactgatctc cccttcaaat cttcaaccat aaatccttcc ctcattttcg
    15241 taactggaaa agacacggtt atagaaaccg tgcctttttt ccatgtattt tcgttattaa
    15301 cacgttttgc agaaggtaag actaacttga caattcaaag tacctgttgc acatgaagga
    15361 gtacagataa taccactggc tggttgaact ccttttggag caacctcatt tttagctact
    15421 tgcaagtcca gatcaaattg atttttcatc ttgttacctc ctttttattt tttacaattt
    15481 tattataagt tatataatct taactagact ttatataatt cttacatttg tcttaatttc
    15541 aacgagtaca tttaagataa accttcatta ttttttagta tttttaagga caacacacta
    15601 gattttagtg acaatataat gaagaaaaaa ataatggagg ctttcatatg aaaattgata
    15661 gttttgttat acaacaatcc gaccaagttc gtgcaagaga tattagtaaa aaaattgctt
    15721 tacgtctatg cgagcccgaa tccgtctatg cagcagtcca tgcggaacac aatgtttcgc
    15781 cagaaacaaa gtaccaccca tggggagaaa cttcactttc gcatggttat cctggtaaca
    15841 ttcatttact atcgcaatgg cgtgctacag acccttcgta tgattggaat agagccatac
    15901 attcaaacat ggctcagatc caatcctcac ttgctaaaaa tggtcttcac gatctctctc
    15961 tttacagtgg ctgggcaggc atcgcttcgt ccgtaagaga ggcttctaat catggaaagt
    16021 actacagtaa tttcttacag caaatacatc aatggatgat gcctcttaca gagcaatggc
    16081 ttcagtcgaa cacagaaaaa ttaagccttc acgaaggtat gcccatgcaa gcctttgaca
    16141 ccatttcggg agcttcaggg attggaagat atattttgat gaactcaacc gatcctatct
    16201 gtactcctct tgttgagcca attcttcaat ttcttaccga tcttacacat cccatacata
    16261 ttcacaatcg ttatgtccca gggtggtact ccccgcaaaa gtttcaattt ttagaccggg
    16321 ataaacgtaa ctatcctctg ggcaatttta attgtggaat ggcacacggt attcctggac
    16381 cgttggcttt attatctgta gcttacagtg ctggaattga agtaaaaggc caatatcaag
    16441 cgattgaaac cattgcggaa tggttgctta agtataaata tgaagatgaa tatggtagct
    16501 actggcctca tattgttcca ttcgaagctg aaacaggctc tctacggttt gatttggaac
    16561 gagcaagaga agcatggtgt tacggtaccc ctggcattgc ctgtacccta tttcttgccg
    16621 gaagggctct ccataatgag gaactgcaaa aattggctgt gaaagcttgt gtcggtgcaa
    16681 tctcctatga gatagctaag cgggaaatgg actcttctgc actttgtcac ggtcttgccg
    16741 gattacttac catctcttgg cgaatgtggt gtcatagtaa agagcctgct tttctcccgc
    16801 ttattcaaca gttaacgaat tgtctgcttg atcgctttca aatggatagc ccactaggat
    16861 atctggaccc cgagccaagg gcagatggct ctctagtatg gctgacaaaa gcgggcatgc
    16921 ttgaaggcgt tgctgggatt gcagctgctt tattaagtgt ttctgagaac aaagagatcg
    16981 gttgggatta catcctcatg ctatcctaac tacaaccagt ccctattcac aaacatcttt
    17041 cttccaccat acagataggc taaaaacgta aaaatgacaa tcagtccgag actgtaaggc
    17101 tcaactctgg gtgcataagt cgctgtttgc ggcatcataa tataataagg aatcgtaaaa
    17161 ggaaaccacg cacctatgga agagtgaaag cctgttatga caatattagg aaccacacaa
    17221 caaatggaca ttcctagaga agctccaaaa ttccgaattt ttatcgagag cataagctgt
    17281 agtgctgcca ggggaaaaat cccgagccac cctcccaaac cggtagaaag aacgacagac
    17341 caagggattt ctcctggagc acctgctata tttccactta caaaatagcc tactataaat
    17401 ataagctgat ccagacccag tatgagaatg agcaatatat attttgcata ataaatttgc
    17461 tgacgaggat acgggctgct taataaaatc ttccatcccc catcccgatg ctcgtacgca
    17521 cacaaaagag aagcaataat tccacaatag agcggataaa aaaacataga gtgaaattgc
    17581 gctgaataag tatataaagt taaccaactg ggtgaaaaaa actgcttcaa atcattcagt
    17641 tccaggactc ccattaaaga atttatgatc gcatccaata taatgagaat ccaaaccatg
    17701 atccattgaa gctttattgt ctccacgcgt aaaatagagc ccatgtatct tttcctctct
    17761 atttgaattc atgcttggta aactgtagtg taccaagtcc cgtaaagatg actcctgcac
    17821 ttaaagcaac gatcacccaa atcatgtgtt ccttcatcag aggacttgat aatgcagggt
    17881 acgaccaagg caatatttta atccacagaa tacttgtgcg tgccaaaaac aagcttgcaa
    17941 ttgaaccgaa tataccaaac gctaatggga atgcctgatt agtgaaaagc gtagacagcc
    18001 aaagttgaat tgcaagtact ggtagggtag ccaagcttgc attaatcggc tgtaacagca
    18061 tgatccgcca aggaatgggt tcgtttgtat ataacaccca gatgaggctc atacctgcta
    18121 cagtgatcaa ggcggtaccc aactgcagaa tcacaatcca tacgattttg gataaataga
    18181 tataacttct gggaacaggc atggccataa gctgcttcca tgtttgagta tcatgctctg
    18241 taccggccat aatgctcgcc aaaagtgtac cgccaagcag catcacaaac gaaaggaaca
    18301 taaacataac ggcaaaacca gcgtagacac ctcccggtcc ttgccgaaag taaagatacc
    18361 attccacagc agtcatgcct gtaagtacac acccctgtat aagaggaatc caccagcata
    18421 ttttcttcag cttaagcccc tctgccttta taacccggag tatcataagc ttcgctcctt
    18481 acctgtcagt tccaggaata tctcctccaa tgtttttttc ttctctgtga cccgataaat
    18541 gggatgattg tgttccacaa gcaccttgat catctccgaa gattgttgcc gatctacaat
    18601 aggagtcacg acctcatttt gttcaatcga ttcagctccg gccgtccacc catgctgaat
    18661 cagtgcaccg gcagccagaa caggatctgg ggtttcaatg aataattgag gcttgctttt
    18721 ggcggtgagt tccttcatcg ttccctggaa gatcatttca ccctgattaa taattcctac
    18781 ataggttgca atctgctcaa tttcgcttaa taaatggctc gaaactagta ccgtcattcc
    18841 gtaagcgcca gggaggctca taattaactc ccgaatttcc tgaataccag acgggtccaa
    18901 accattcgtc ggttcatcaa gtatcaataa tttggggttg gcaataagcg ccatagcaat
    18961 ccccagtctt tgtcgcatcc ccaaggaata tccctttacc ggacgatacg catccttggt
    19021 taatctcact aaatccagca cttcatgaat tcttcgggtc ggcagtccac gcatggttgt
    19081 aacgatttct aaatttcgat atgcggataa atgggcataa taggcaggtg attcaaccaa
    19141 ggaaccaata tccttcaata tttccatacg ctgatccttc agctttttcc caaaaatctc
    19201 aatttccccg gatgtggatt taatcagccc aagtagcata cgaatcgtgg ttgttttacc
    19261 cgctccatta ggtcctaaaa atccataaat ctgctgtccg ggtacctgga gatttattcg
    19321 ttttacaaat tcccgttttc caaaacgcct agttagctgc tgtgtatgta ttacatattc
    19381 agacatttcc tgatctcctc tcgacttcta atgctgaagc ttaagttaca tacagtttac
    19441 tgaagtaaag taaacatcag gtaaacagtc cctaaacaac aggcaaaaaa accgagcaaa
    19501 ctgcaaaatg tgagatcaaa tgttaaaaag ttagatgttt agcggcagtg aaatctccat
    19561 cctagtaccc gctttactgc ctgaaaggat atgaagcgtt ccgttatgcg cctcaataaa
    19621 gcttttggca ataggtattc catgcccttg ggaatgagat acctgcatgt actcattgga
    19681 attcattcct attccgtcgt cttcgataga aatatgaagc ttatcgttcg ctttgcttac
    19741 ttccatggaa acgtgtgtac ctggaggatt atgaatgata gcattaatca aaaaattctg
    19801 gagcgctctg cctaataatt tactatcgaa gggcataata catgccgcgt ccattgacgt
    19861 aaaagaaaat tcgtattgct cggctgaagg atggttagcg atatctatga ccgcactacg
    19921 tagaaactcc acaatgtcct ccttctccaa ttggattggc aatggacctt ccttaagctg
    19981 catagaagca ttcaaatcct gaatcaactg cttcatttcc gtcactttct cactgatacc
    20041 catactaaag cttcttcttt cttcatcaga ccagtcatac tcttgagcag tcagcatgac
    20101 cgcatatcct tcaatataag ataatggtgt tttcagatca tggcttacac ctgctaccca
    20161 ctgctgtttt cgtttctcta tttccactct ctcttcctca ttgctgcgca attgggccga
    20221 taagatgttc atttgttcaa aaacttcttt atacaattga tacggaggtt tataactatt
    20281 tttctgattt tttttgccct ctggcagttc cagttcactt agcggcgctt ggaattcccc
    20341 tgtcgcaata tttccaatcc atttaattac atacaccaaa ggtttgccta tataccatcc
    20401 gtaggcagct atgaacacaa cactctgcac gataccaagt cctgtccaga atagatcaat
    20461 atttatattt tgagatgctc caaatatact ttttataaaa atatataaga tcgtgcaaat
    20521 aacaaaacat agaacatagg ccagtacaaa gcataacgtt actttcataa aacgaaagga
    20581 catcttaact agagagttca ttcttgctcc tccatcttga ctgacatcat tttataacca
    20641 agtcctctta cattgattaa aaattgcggg tgcttgggat caggttctat ttttttccgc
    20701 aaacgggaga tatgaatcac tacggtcttc tcatcaccca agaaggcctc gctccatatc
    20761 gcctcataaa gctgccgtac actgaaaata cggttaggat gcttgcacag aaataccagc
    20821 agtagccatt cacgtgccgg acaatcgacc tgcttgtcct ccacatacaa tacaccggat
    20881 tccagttcca gacgaaaata tccaaaatct aaagtgcgta aggtcggttt catggccact
    20941 gtcgaaactt tccgatattt cattcgagct ttcatacgcg caacgacttc cagcgggtta
    21001 aacggtttgg taatataatc gtcccctccg ataccaaacc ccattaattt gtctaggtct
    21061 gtatctcttg ccgtcaaaaa aagaataggg gcatccgtat atagacgcat ttgacgacac
    21121 acctcaaacc catcgttatc aggcagcata acatcaagta caatcacatc cacatgagat
    21181 tccatcacga cttgcagcgc ttcccgaccc gttgcagcat gcttgacttg aaggaatcct
    21241 tcttttttta acaccgttgt cagcatatcc cgcaacccct gctcatcgtc tactataagt
    21301 actgcaattt cttccataac ccaaggttct ccattctttt tttacatttt ttactttcat
    21361 tataaaagca aacgggcaga atttaaatcg agttccatca catatcgttc atccccgtga
    21421 atatacttaa taaccaacaa ggccaaactg tgccgtgtat ccacttgggg ggtgcctaat
    21481 aatgccggaa ccacgccagc catattcatt cgtcgtatcc cgcgaagatt ggtcgctgca
    21541 tcgcaaaggg taccaggacc agcaacgtca tcagcagaag gtcaaagatg tcattaagca
    21601 aaatctaccc gatctgataa cggaagaaaa tattattatg tcggacggtc aacagattat
    21661 taaagtgccg attcgcagtc tggatgaata tcgcttcatt tataactatc aaaagcaaaa
    21721 gcatgtaggc caaggagatg gcgacagtca ggtgggggat gtcattggac gtgatcctgc
    21781 ttcccagaag ccaggtaaag gtgagaaagc cggcgaccag ccgggacacg atattatgga
    21841 aacggaagtc agcatagaag aactggaaga tatgctgttt gaggaaatgg aattgccgaa
    21901 tttacagcaa aaagacaagg atcaaattga ggttgaatct atcgtattta atgatatacg
    21961 taaaaaaggc atgcaagcga acattgacaa gaaacgaacc attctcgaaa atctgcgccg
    22021 caacgcccgt gaggggaaac cgggcattca tcatattagt ccggacgatc ttcgctacaa
    22081 aacatgggaa gagaagacca ttccccaatc caacgcggtg attatagcta tgatggacac
    22141 ctcaggttcg atgggctctt ttgaaaaata ttgcgctcgc agcttctttt tctggatgac
    22201 ccgctttttg cgccgtcagt atgaaaaggt ggaaattgtc tttctcgcgc atcataccga
    22261 ggctaaagag gttacggaag aagaattttt tacccgcgga gaaagtggcg gcacaatctg
    22321 ctcttccgct tatttgaaag cactggagat tatcgacaaa cgatatcctc cttccagcta
    22381 caatatttat cccttccatt tctcggatgg cgataacctg acctcggaca atgagcggtg
    22441 tgtgaagcta atcgaggaac ttataaagcg gagcaatatg ttcggctatg gagaagtgaa
    22501 tcaatataat cgcagcagca cgctgatgtc agcctacaag aatattaaaa aggatcagtt
    22561 tatgtactat gtcatcaagg aaaaaggtga ggtataccaa gccttacgta ccttttttcg
    22621 caaacgggaa gggggatcgg tgggatgagt accgaccaga aggagctaga atatgcgata
    22681 tcagaaatta tggagattgc cgatggattc gggctcgatt actacccgat gcggtatgag
    22741 atttgtccgg cggatattgt atacacgttc ggagcctatg gtatgcccac gcgcttcagc
    22801 cactggagtt ttggaaaaac atttcacaag atgaaaatgc agtacgattt tggattgagc
    22861 aaaatctatg agctggtcat taactccaat ccctgctatg ccttcctgct ggaaggaaat
    22921 tctttggtgc aaaataaact gattgtcgcc catgtactgg cacactgtga ttttttcaaa
    22981 cacaacgctc gcttctcagc ttctaatcgc aatatggtag agagtatgtc ggccacagca
    23041 gatcgaatca acagctatga aatggaatac gggtcaaagg ctgtagaatc cttcattgac
    23101 tctgtactgg cgatacaaga gcatgtagac ccacagatta tcaaaccaag gcatctggat
    23161 aaacagcgtt acatggagct caaaattcgg gagcagaaag aacccggaaa acgccagcgt
    23221 ccccctggac cttacgatga tctgtggtca ctggacacag tgaagcagca taatccagcc
    23281 gagaccgagg gcatcaagat acgccagttt ccaccggaac ctgaaaaaga tatcgtctgg
    23341 tttattcagg aattctcgga ggtactggag gactggcagc gggatattat gacgatgcta
    23401 cgggacgaaa tgctgtattt ctggccccaa atggagacca aaatcatgaa tgaaggctgg
    23461 gcctcctatt ggcaccagcg gattgtaagg gaactggatt taaccgggga ggaaaccgtt
    23521 gaatttgcga tgctgaacgc ttctgtcgta cagccttcca agcaaagcct gaacccgtac
    23581 tatttgggac tgaaaatatt tgaggatatt gaaaaacgat gggataaccc aacccgtgag
    23641 gagcaagagc gacaaggacg caaaccgggc gaaggacgcg ctaaaatgtt cgaggtacga
    23701 gagttcgact cagacacctc ttttatacgc aattacatga ccaagaaact gacagaggat
    23761 ttggatctgt acgtgtttga gaaacgggga cccgattgga aaattaccga taaatcctgg
    23821 gaaaacatac gggatcagct cgtgttttca cgtgtgaatg gaggctcccc ttatatcgtc
    23881 gtcgaggatg gagattacct gcatacgggc gagttgaagc tcaagcacca gtacgaaggc
    23941 attgagctgg atttaaaata tatggagcgc acacttccgt atgtatatca gctgtggggg
    24001 cgcaccgttc atttggaaac attgattgag ggtaagctcg ccttattctc atatgacggt
    24061 aagaaacatc atcgtaagtt tgtatagtca tacaaaatca aatagccagc ctaatttaaa
    24121 aaaggggcat tcctaaaaag gatatgcgcc ttttttttac tatttcatac aaccttaagc
    24181 gaccttcgtt tcttgccaat ttcaggacac ctgtttcgtt ttggatcagg ggtgtattat
    24241 actaatatga taaatgaccc acgggtcata gttgagaagc agaacgagga gcgttgatat
    24301 agatgaacac ccatcccagc tttcgtgaag ttcgtgaaag tgatcagcag gtattcccga
    24361 tcgcctggta tgccgttggc tggtccaagg aactaaagaa taaaccgctt aaaaagcgac
    24421 tgcttggcaa agatattgtc ctgtaccgtg atgatcatcg tcaggtacat gccatccatg
    24481 cttattgccc gcaccgagga gctgatttat cgctcggcta ttgtcaaagc gggcacatca
    24541 catgcccata tcatgcatgg tctttcgatg agagtgggca gtgtgtggat attccggcac
    24601 acccgggacg ggctattcct gagtttgctc atacctatgc ctatcccgcg attgaaaaag
    24661 ccggcctgct gtgggtatat cctcaggccg ttggctcaaa gtctgagata aactcagaga
    24721 tggggacatc cacgtcccca cctcctctgg agatttttcc cgagctggag gacccctctc
    24781 tcattttgtc tccctacgat tccgtgtgga aggcacatct gacgagagtt gtggagagcg
    24841 tgctggatgt cgctcatttg ccaattgtcc ataacaaaac gatcggtaaa aaatcctcca
    24901 ccgacattca tatcgagttt gaagcggatg acaatcatat tcgagtgaaa aacgggaaag
    24961 gtctattgca atataccttt ccacagcaat ggattttgac tcccgtaaaa gaaggacgca
    25021 gcaagtttat taatttcgtc accttcactc cgattgagca agagttaact gccatctacg
    25081 gaatggctgg acgtaatttt gccagatttg taccgggtat gagccacatt ttttccagat
    25141 acagtggcaa ggtgctggaa gaggatcggg ccgtggtgga aagccagcat ccgcgtccaa
    25201 tcccagaagc gctgcgaatg gaggcacacg tccccgctga tggacctcag gttcggtttc
    25261 gcaaccgctg gtatgatttc cttgtcaacg atgagcctcg tgtacgactg ggtccagaaa
    25321 ctacttcctc ttaaattcga cgatgtagct ttgattgagc tgttttccac cttccgagat
    25381 gttctggtac atggataaaa accgggcgga tgggctccat accgttgggc tgtcatagga
    25441 ttggatatcg gtcgtaaccg gagtggtttt acccgtggac tggtcaaaca catacagccc
    25501 tctcatgcct tgctgatcct catcataaat ggaataagca agcttggacc cgtcgctgga
    25561 ccagcttcca cgactcatta aagtgccttg accgacgatt cctttctctt tgccctgttc
    25621 atccaaaatg atcatacggg ctggttcgga tgtattccat ttccgttttt caatggcaat
    25681 tgacttacca tcaggcgaca cggcaaagga catggccccc tctgcaatgg tcacagcctg
    25741 aggatgattg agggtgaacc gattcagcac cggataccct tgtttatcac tgcctgtata
    25801 aaatatggcg ttacccactt tttcgacatg agacatcaat tcagagcgat ttggatcttg
    25861 aaaactcaat tctttagctt ttccgtccag accaatcagc tggattttac catccggtgt
    25921 gcctgtaatg agatcattct catcgctcca gctcacttcg ttagtcatat ccagcttgcc
    25981 gatcgatgta accttaccac tgcttagctc caaaatgtag ccctgaatat catatttgct
    26041 gctggtgcta ccttcagtaa aaaagacatg gcgctgatcc ggtgatacca cagcaagtaa
    26101 ctgtggagcc ttacgacctg gtgttaaaat ccgctccttg tctgtctcta cattatgaat
    26161 ccacagctgg gttttacgct ccacaatcag ctcttcgtcg ctcagccaag acctcgcgta
    26221 gacatccccc agcctgtcga tagacgatac caccagctcg tccgttactt gctgctgggc
    26281 tgcatccgtg tcaatcacag taagctgttg ccccggtttc ataccggatg ctggatttgt
    26341 ctctcctgcg ctctttatgc cgcaaccgct gaacaatccc ccggcgatta agccggccat
    26401 gagcaccccc gtggctttct gtctgaaaac tcttgtacgg gaatcttcgc gatgagagga
    26461 gccgttcttt tgcccatagc tgcctatgtt tttctttatc atgtacaacg gcctccttgt
    26521 taacgatacc cccattttaa tgcccgaaca tctcatgaat acatcggatt gtttccaaat
    26581 tgtaaacaag acaccatttt agccctgtgc taacagttgg ccgtttacag ggagccatcg
    26641 tgaaccaaga gagggagtct aagcgaaaat tcattcccac ttacatttgt atgcccgttg
    26701 tcattttcca acccactatg atctgaagct gtaagctgca actctccccc catgcgctcc
    26761 gctagtctgc gcgccagagg aagaccgagt cccgtaccgc tgtcctgacg agatcgatca
    26821 cgacttaagg tagcaaacgg ctcaaaaatc atgtcccatt gctccctagg aatccatggg
    26881 ccggaattgc gtatacacac aatcacggtg tcctgttcta ctcgattcga taacgtaatc
    26941 catccaccgt cccgattgta cttcactgca ttatccagca aattcagtac aatatgcatc
    27001 agatgctta
//
