LOCUS       NZ_FOYL01000015        10819 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Lentzea waywayandensis strain DSM 44232, whole genome shotgun
            sequence.
ACCESSION   NZ_FOYL01000015
VERSION     NZ_FOYL01000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Lentzea waywayandensis
  ORGANISM  Lentzea waywayandensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Lentzea.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900115955.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 15:54:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,449
            CDSs (total)                      :: 9,363
            Genes (coding)                    :: 9,244
            CDSs (with protein)               :: 9,244
            Genes (RNA)                       :: 86
            rRNAs                             :: 5, 4, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 5 (5S)
            partial rRNAs                     :: 4, 6 (16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 119
            CDSs (without protein)            :: 119
            Pseudo Genes (ambiguous residues) :: 0 of 119
            Pseudo Genes (frameshifted)       :: 26 of 119
            Pseudo Genes (incomplete)         :: 101 of 119
            Pseudo Genes (internal stop)      :: 5 of 119
            Pseudo Genes (multiple problems)  :: 12 of 119
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:39:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 171778
            Orig. end                         :: 182597
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOYL01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10819
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10819
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10819
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5819](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5819
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            596..886
                     /locus_tag="BM417_RS39845"
                     /old_locus_tag="SAMN04488564_115158"
     CDS             596..886
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800404.1"
                     /locus_tag="BM417_RS39845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488564_115158"
                     /product="hypothetical protein"
                     /protein_id="WP_093605242.1"
                     /transl_table=11
                     /translation="MGDSKDENEKFQEELIGLDPHDPETKAFADHLDKMKRQRPGFTVE
                     GYLDGVQDFADSANRTTGHQRLVAVIIVGLILLGVLLTIWFALGDILAIIF"
     misc_feature    complement(638..651)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.84"
                     /tool="antismash"
     misc_feature    complement(911..926)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            999..1421
                     /gene="msrB"
                     /locus_tag="BM417_RS39850"
                     /old_locus_tag="SAMN04488564_115159"
     CDS             999..1421
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422371.1"
                     /locus_tag="BM417_RS39850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488564_115159"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_093605244.1"
                     /transl_table=11
                     /translation="MEPVVGATPKVVRSEEEWRAQLNPAEFAVLRQAGTERPWTGEYTE
                     TKTEGLYECRACGAELFRSDTKFDSHCGWPSFFSPLAGDSVILREDRALGMKRVEVLCA
                     TCHSHLGHVFEGEGYPTPTDQRYCINSVSLKLVPSE"
     gene            1679..2569
                     /locus_tag="BM417_RS39855"
                     /old_locus_tag="SAMN04488564_115160"
     CDS             1679..2569
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="BM417_RS39855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488564_115160"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_093605245.1"
                     /transl_table=11
                     /translation="MQRPWGLSGPEFLQLYWIGLALAVLVAIVVRVRVRAGHSTQPVRS
                     LDMDELAYLAGGPRRVVETAIARLLTSGELRTSRRGTVQVTSTTKSLNQVDRAVITDSQ
                     RYTNRTVNLMIPAVAGDGVVTAIGQRLQDMGLVVDPGVAKSALRKGSIALWVLLAIGIA
                     RWVNGLAIGANIGWLTLQLVITGLLILLLTRRGKHVRTSKGNRVLDGARTTSTRAAGSV
                     DEVMYAGAAGAVLFGGLIVYPDLAVRTSLLASSGSGSSYSSSSYSSCSSSSSSCSSGSS
                     CGGGGGGGGCGGGGG"
     gene            2659..3465
                     /locus_tag="BM417_RS50410"
                     /old_locus_tag="SAMN04488564_115161"
     CDS             2659..3465
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="BM417_RS50410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488564_115161"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_143139003.1"
                     /transl_table=11
                     /translation="MSKSSAPHQTTWSAEEIGFLAGGPGRAAEAVLARLLDGGLVRISR
                     EGLVTAVHQNGYGARTALEAYVLAGLQGTARPIQQVVQVARASHEMGALHQSLVARGMV
                     HRQFGRPRGGKIALRVVLFLLAFVSVFVAFAIDTRLFLLTALLVFLAILLRNPGRLTRN
                     GKTVWMYALRNPRSSADAVALFGLRRGKQRTTSSTPYVGTSGCSSYDWNHHSCGGTSSC
                     SGNSCNSSSSCGSSSSSCSSSSSSSCSSSSSSCSSSSSSSCSSSSS"
     gene            3476..4228
                     /locus_tag="BM417_RS39865"
                     /old_locus_tag="SAMN04488564_115162"
     CDS             3476..4228
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="BM417_RS39865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488564_115162"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_177320870.1"
                     /transl_table=11
                     /translation="MTKQTDTQGAWLSAEEAGFLTAGPGRAAEAVLARLIDQGLLRVSR
                     DGLVSAVHQDGEGATTSVEARMLSFARNPVQFDAIVLATRNCTEVAQLYRQLLSRELMR
                     VPHRRHDGRWFSLAVAGVAVVLGFVSPVFLVAAAIALGFFVWQNGSGPITQAGREALSQ
                     VQASDRVHVVALYGFDGRFRGKDVGELFDFPRRVVRTVPRRPARARRRSIWNGGGCGSS
                     SSCGSSGCAGSSSSCGGGSGCGGGGGGD"
     gene            4228..5001
                     /locus_tag="BM417_RS39870"
                     /old_locus_tag="SAMN04488564_115163"
     CDS             4228..5001
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="BM417_RS39870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488564_115163"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_177320871.1"
                     /transl_table=11
                     /translation="MAAPTAATGTRVPPEQIGYLVAGPGRAAETALARLLDAGLVRVSR
                     DGLVSAVHQTELGVSTAVETLILINLRRPARFDAVVRNAAKSTEMRTLHQQLRARRLTR
                     DPRPRLAAWWVFLAIGVVLSLTAFLKPWTLLGAVGFLGAAYWTFGAKPLTRSGRTALKG
                     VTASDRVLAVALEGFRGKVDRQQNVGDLFGLSQSVVKMLPRKRKKPVRRGGGGASDASC
                     GGGCGSSSCGSSGSSCSSGSSSCGGGSSCGGGGGD"
     gene            5001..5819
                     /locus_tag="BM417_RS39875"
                     /old_locus_tag="SAMN04488564_115164"
     CDS             5001..5819
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018684640.1"
                     /locus_tag="BM417_RS39875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488564_115164"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_093605251.1"
                     /sec_met_domain="DUF692 (E-value: 7.7e-87, bitscore: 284.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGIKDLGVGIGWRSEIDLTVERLPGVDFVEVVAENLHIGHLPES
                     VTLLLERGVPVLPHAVSLSLGGADEVDLHRVEHLGAVAEAVGAPMVSDHVCFVRAGGLD
                     SGHLMPVPRTKDALDVLVANVKLAQRNLPVPLALENVAALLEWPDGELSEGQFLAELVE
                     RTDCWLLVDVANLYANARNIGTDPERFLDEIPLERLAYVHVAGGEQHGDIYHDTHAHAV
                     LPEVLDVLDELCSRVAPPGVLLERDDNYPSDTEIASELAAIRAVVDKHRG"
     gene            5824..6183
                     /locus_tag="BM417_RS39880"
     CDS             5824..6183
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671914.1"
                     /locus_tag="BM417_RS39880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_093605348.1"
                     /transl_table=11
                     /translation="MNENEVSAARERLATRQAELLNALLGNGPAPAGFDEQRLAVERRA
                     LLSKRRGIVRMLGPAVADELGDRFRPLFDAYAVEHPRRAGSRAREDAAAFAEWCRASGE
                     LSAKRKARWKFWQSN"
     misc_feature    6225..6242
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.47"
                     /tool="antismash"
     misc_feature    complement(6227..6242)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    complement(6327..6342)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.25"
                     /tool="antismash"
     gene            6360..9449
                     /locus_tag="BM417_RS39885"
                     /old_locus_tag="SAMN04488564_115165"
     CDS             6360..9449
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099298.1"
                     /locus_tag="BM417_RS39885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488564_115165"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_177320872.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.2e-62, bitscore:
                     204.1, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGKTKVLSAVTALALTAASAAAATAAPPAGTTPQKAADEVTLVT
                     GDKVLLGQDGQVVAIQPGEGRKNMIFKTARRADGHTMVVPKDAFEPLAAGRLDSRLFDV
                     TTLLEFGYRDRMPLIVDGRARVGARSSGDWAALRTEAATGDKIWLDGIRKPSLDRSVAQ
                     IGAPAAHQKGITGKGIKVAIVDTGVDEKHPDLAGQQIAEKNFTTDPDNTDNVGHGTHVG
                     STVASHDSKYGGVAPGAQLIDAKVCVEFGCQESWILDGMRWAAEQGAQVVNMSLGGGDT
                     PEVDPLEQAVNDLTAQYGTLFVIAAGNSGSTGSVSSPSTAEAALSVGAVDRDDKLAPFS
                     SKGPRVGDSGLKPEVTAPGVDIVAAKAGTSDHLAGSGTSMATPHVAGAAALLRQQHPEW
                     TPAQLKSVLATTAKPTEGVSAFDQGAGRIDVAKAIGQVLTADVVAVNLGLHEWPHADDK
                     PVTKPITYSNPTDAAITLDLAFKGSAPAGMFTLGASKLTVPAKGTASVTVTGDSRVGTK
                     DAAYSGEIVATSGPHTVRTLVGIDREVESYTLSIDMIGRDGGDPADSFTFIAGLDNDTF
                     KAVFGAGDQKIRLPKGTYFLDTTLGNGPQGMDMLYQPTVKLTSDQTIKQDARLAQPVSV
                     KAPEPVGDFAIGLIAVKRSVGGEPRLRSTSVMFGGFDGVAIAQGGAQLPPDELSSLAML
                     QTNAAADPHTFYRLAYPFAGGLPVGLTKAPAKKELARVESTIGGQKPDSQASKGELPLS
                     PQGLSGGTALYPVAVGATAVDYVTPEGLRWQSAIMTRHANGAQERITSGLRKYQAGKTY
                     REREVRPVFSPGLPESEYGFVERYGTQLYVSVPLVSDANHGDGRSTVDSARTALYRNGV
                     LIGETTTPGGSFSNVPLPQADFRAEMSLDRSSQFEFSTRVSAVWTFKSKGTEGKIDAPP
                     LSVVRFEPKLDDNGAVPAGTLQRIGLLTQTQGDAGKVRITGVEYSHDDGKSWRRAGVVG
                     NSALVYNPANAQWTSLKATATDAKGGTVELTVIRAYKVGA"
     gene            complement(9453..10145)
                     /gene="hemQ"
                     /locus_tag="BM417_RS39890"
                     /old_locus_tag="SAMN04488564_115166"
     CDS             complement(9453..10145)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983668.1"
                     /locus_tag="BM417_RS39890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488564_115166"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_093605255.1"
                     /transl_table=11
                     /translation="MARLNYNELNDTIRYTMWSVFRVEPGKLPDDRSAAAAETQNYLDA
                     LEGKGVVVRGVYDVAGLRADADFMIWWHAEEIEQVQAAYTGFRRTPLGKVSTPVWSQVA
                     LHRPAEFNRSHIPAFLAGEEARKYICVYPFVRSYEWYLLPEEDRRKMLADHGKEARDYP
                     DVRANTVASFALGDYEWLLAFEADELHRIVDLMRHLRGTEARLHVREEIPFYTGTRVPA
                     AELVLNLP"
     misc_feature    10544..10555
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
ORIGIN
        1 ggccaacggc tggccgaccg gcagctacct cgacccgacg cacccgttgc aggtcgcgac
       61 ccgcgagacc atcgaggacg tggccggcga gcccgtcgcc caggtcggcg tggacggctg
      121 cggcgccccg atcttcgcca tcagcctcac cggcctcgcc cgcgcgttcg gccgtctcgc
      181 cgccgcggcc cccggcaccc tcgaacaccg cgtcgccacg gccatgaaca cctacccgca
      241 gtgggtcggt ggcaccggcc gcgacgtcac cgtcctcatg gacgccctgc ccggcctcat
      301 cgccaaggac ggcgccgagg gcgtctacgc ggtcggcctg cccaccggcg agggggtggc
      361 gctgaagatc gccgacggtt cgtcgcgcgc ccgtgcggtc gtcatcgtcg cggtgctcaa
      421 gcggctcggc gtggacgtga gcaaggtcga ggacctcgcc accgtgccgg ttctcggaca
      481 cggccgaacg gtcggcgccg tcaggccgtc gctcgcactc gcgagttgac cgtcactcca
      541 gcggtgaaca cccagcacac gggaatcccg tcccccagcc actaagctgg gggttatggg
      601 cgattcgaag gacgagaacg agaagttcca ggaggaactg atcggcctcg acccacacga
      661 tcccgagacg aaggcgttcg ccgaccatct cgacaagatg aagcggcaac gccccggctt
      721 caccgtcgag ggctacctcg acggcgtgca ggacttcgcc gactcggcga accgcacgac
      781 cgggcaccag cggctcgtcg cggtcatcat cgtggggctc atcctgctgg gcgtgctcct
      841 caccatctgg ttcgcactgg gcgacatcct cgccatcatc ttctgagtcg cacaccttct
      901 ggccacaaac gagaacaagt ccttaacggg gccttacggc gccacagccc acagcctcgc
      961 cgggaagccc cgagggcact ccggagttat aaagagtcat ggaacctgtt gtcggcgcca
     1021 cccccaaagt cgtgcgttcc gaagaggaat ggcgcgccca gctcaacccc gccgagttcg
     1081 cggtgctgcg ccaggccggc accgagcgtc cgtggaccgg cgagtacacc gagaccaaga
     1141 ccgagggcct ctacgagtgc cgtgcctgcg gagccgaact cttccgcagc gacaccaagt
     1201 tcgactcgca ctgcggctgg ccgtcgttct tctcgccgct ggccggtgac tcggtcatcc
     1261 tgcgcgagga ccgcgcgctc ggaatgaagc gcgtcgaggt gctctgcgcc acgtgccaca
     1321 gccacctcgg gcatgttttc gaaggtgagg ggtatcccac ccctacggac cagcgctact
     1381 gcatcaactc cgtctccttg aaactcgttc cgtccgaata ggagactgag cctcagtccg
     1441 gtcaccaagg atccggacag acctgggagg caccatgatc ttccgcatcg tcctgcgcgg
     1501 caccgacggc gaaggctcca gcggagtcga tggcggctcg tcgagctagc cgcaagcgcg
     1561 aaacagggac agaaggccgg caaccctaag gcttcgtcaa caagccttgt gaggctgtgg
     1621 cgcggaccac accattgacc caccgaagca ctttcggggc agtcaggggg tgggtcgcat
     1681 gcagaggcct tggggattgt ccggaccgga gttccttcag ctctactgga tcgggctggc
     1741 actcgcggtg ctggtcgcga tcgtcgttcg ggtacgcgtg cgggcgggtc acagcactca
     1801 gcccgtgcgc tccctcgaca tggacgagct cgcatatctt gcgggcggtc caagacgcgt
     1861 ggtcgagacg gccatcgcgc gactgctcac ctcgggtgag ctcaggactt cacggcgtgg
     1921 caccgttcag gtcacgtcca ccacgaagtc gctgaaccag gtggaccgcg ccgtcatcac
     1981 cgacagccag cgctacacca accgcaccgt caacctgatg atccccgccg tcgccggcga
     2041 cggcgtggtc acggcgatcg ggcagcgtct ccaggacatg ggcctggtcg tcgacccggg
     2101 cgtcgcgaaa agcgctctgc gcaagggatc catcgcgttg tgggtactgc tcgcgatcgg
     2161 gatcgcgcgc tgggtcaacg gcctcgcgat cggcgcgaac atcggctggc tcacgctgca
     2221 gctcgtcatc acgggcctgc tgatccttct cctcacgcgg cgcggcaagc acgtccgcac
     2281 cagcaagggc aaccgcgtgc tcgacggcgc tcgcaccacg agcaccaggg cggcgggaag
     2341 cgtggacgag gtcatgtacg cgggcgcggc cggcgcggtg ctcttcggcg gcctcatcgt
     2401 ctacccggac cttgcggtgc gcacctcgct gctcgcctcc tccggctccg gcagcagcta
     2461 cagcagcagt agctacagct cgtgttcatc cagttcttct tcgtgttcaa gcggaagcag
     2521 ctgtggtgga ggcggcgggg gcggtggctg cggcggaggc ggcggctgat cggttgttcg
     2581 gacctgttca ggtaacaaca ggaacccagg ggtagatctc acgtcgaaga tgcactgaca
     2641 ccagtgaggg gagtgctgat gtccaagtct tcggcaccgc accagaccac gtggtccgcg
     2701 gaggagatcg ggttcctggc agggggaccg ggcagggcgg ccgaggccgt tctcgcccgg
     2761 ctgctggacg gcggtcttgt gcgaatctcc cgcgagggac tcgtgaccgc cgtccaccag
     2821 aacggttacg gcgccaggac cgcgctggag gcgtacgtcc tcgcgggact ccagggcacc
     2881 gctcgcccga tccagcaggt cgtgcaggtc gcgagggcga gtcacgagat gggcgcgctg
     2941 caccagagtc tcgtcgcccg cggcatggtg caccgccagt tcggcaggcc ccgcggcggc
     3001 aagatcgcgt tgcgggtcgt gttgttcctg ctggcgttcg tctcggtgtt cgtcgccttc
     3061 gcgatcgaca cgagactgtt cctgctgacg gcactgctgg tgttcctcgc gatcctgctg
     3121 cgcaacccgg gcaggctcac gaggaacggc aagaccgtgt ggatgtacgc gcttcgcaac
     3181 cctcgcagca gcgcggacgc ggtggcgttg ttcgggctgc gacggggcaa gcagcgcacg
     3241 acgtcctcca ctccgtacgt cggcaccagc ggttgtagtt cgtacgactg gaaccaccac
     3301 agctgcggcg gcacgtccag ttgttctgga aacagctgca acagttcgag cagttgcggt
     3361 agttccagta gcagttgttc gagcagcagt agcagcagct gtagcagcag cagctcgagt
     3421 tgcagcagca gtagtagcag tagctgcagc agttccagca gttgaggggg aatcaatgac
     3481 gaaacagaca gacacgcagg gagcgtggct gtccgcggag gaggccggtt tcctgacggc
     3541 cggtcccggc cgggccgcgg aagccgtgct ggcccggctg atcgaccaag gcctgctgcg
     3601 ggtctcacgt gacgggctgg tctccgcggt gcaccaggac ggcgagggcg ccaccacatc
     3661 ggtcgaagcg cggatgctga gcttcgcacg gaaccccgtc cagttcgacg cgatcgtcct
     3721 ggcgaccagg aactgcacgg aggtggcgca gctgtaccgg cagctgctca gccgcgagct
     3781 catgcgggtg ccccaccgcc gccacgacgg ccggtggttc tccctcgcgg tcgcgggtgt
     3841 ggcggtggtg ctcgggttcg tctcacccgt gttcctcgtc gccgcggcga tcgcactggg
     3901 tttcttcgtc tggcagaacg gcagcggccc gatcacccag gcgggcagag aagccctgag
     3961 tcaggtgcag gcgagcgacc gggtgcacgt ggtggcgctg tacgggttcg acggcaggtt
     4021 tcgcgggaag gacgtcggcg agctgttcga cttcccgcgt cgtgtggtga ggacggtccc
     4081 gcgcaggcct gccagggcga ggcggaggtc catctggaac ggtggcggct gcggttcgtc
     4141 gtcgagctgt ggcagttccg gttgcgccgg ttccagttcc agctgcggcg gcggaagcgg
     4201 ctgcggtggc ggcggagggg gagactagtg gcggcaccta cagcggcaac gggcacgcga
     4261 gtacccccgg aacagatcgg ttatctggtg gcggggcccg gccgggcggc ggagaccgcg
     4321 ctggccaggc tgctcgacgc cggcctcgtg cgggtgtccc gcgacgggct cgtgtcggct
     4381 gtacaccaga ccgagctggg cgtctcgacc gcggtcgaga ctctcatcct catcaacctg
     4441 cgcaggccgg cccggttcga cgcggtcgtg cgcaacgccg cgaagagcac ggagatgcgg
     4501 acgttgcacc aacagctgcg cgcacggagg ctgacccgcg acccccgtcc ccggctcgcg
     4561 gcgtggtggg tcttcctcgc gatcggcgtc gtcctgagtc tgaccgcctt tctgaagccg
     4621 tggaccctct tgggcgcggt ggggttcctg ggggccgcgt actggacgtt cggcgcgaaa
     4681 ccgctcacca ggtcaggccg aacggcgttg aagggcgtga ccgcgagcga cagggttctc
     4741 gcggtggcgc tggagggttt ccgaggcaag gtcgaccgcc agcagaacgt cggcgatctc
     4801 ttcgggttgt cgcagagcgt ggtcaagatg ctgcctcgca agcggaagaa gcccgttcgg
     4861 cgcggcggcg gcggcgccag cgatgcgagc tgcggcggcg ggtgtggcag cagcagttgt
     4921 ggtagcagtg gcagcagttg ttcgtcgggc agcagcagtt gcggtggcgg cagcagctgc
     4981 ggcggcggag gaggcgactg atggcgggga tcaaggacct gggtgtcggc atcggctggc
     5041 gctcggagat cgacctgacc gtggaacggt tgcccggcgt ggacttcgtc gaggtcgtcg
     5101 ccgagaacct ccacatcgga cacctgccgg agtcggtgac gctgctgctg gagcgcggcg
     5161 tcccggtgct cccccacgcc gtgtcgctgt cgttgggcgg cgcggacgag gtcgacctgc
     5221 accgggtcga gcacctgggc gcggtcgccg aggcggtcgg cgcgccgatg gtcagcgacc
     5281 acgtgtgctt cgtgcgggcg ggcgggctcg actccgggca cctgatgccg gtgccgcgca
     5341 ccaaggacgc gctcgacgtg ctcgtcgcga acgtcaagct cgcccagcgg aacctgccgg
     5401 tgccgctcgc gctggagaac gtcgccgcac tgctggagtg gccggacggt gagctgtccg
     5461 agggccagtt cctcgccgag ctcgtggagc gcacggactg ctggctgctc gtggacgtcg
     5521 cgaacctcta tgcgaacgcc cgcaacatcg gcacggaccc ggagcggttc ctggacgaga
     5581 tcccgctgga gcggctggcc tacgtgcacg tggccggcgg cgaacagcac ggcgacatct
     5641 accacgacac gcacgcccac gcggttctgc cggaagtcct ggatgtgctg gacgaactgt
     5701 gctcgcgcgt cgccccgccc ggcgttctgc tggaacgcga cgacaactat ccgtccgaca
     5761 ccgaaatcgc gagcgaactg gccgcgatcc gcgccgtcgt ggacaaacac cgtggctgaa
     5821 atcgtgaacg agaatgaagt ttcggcagca cgcgaaaggc ttgccacccg gcaggcggag
     5881 ctgctaaacg cattgctcgg gaacggaccg gcaccggcgg gattcgacga acaacgcctg
     5941 gctgtcgaac gccgcgcgtt gttgtcgaaa cggcgcggca tcgtgcggat gctgggaccc
     6001 gccgtcgccg acgagctcgg cgaccggttt cggccgctct tcgacgccta cgccgtcgaa
     6061 cacccacgtc gtgcgggttc acgcgcacgc gaggacgccg ccgcgttcgc ggaatggtgc
     6121 cgtgcctccg gagaactgtc agcaaaacgc aaggctcgct ggaagttctg gcagtcgaac
     6181 tgacgggcga acggttcgac gaccagaatc ccccattcgg ccctgtgtta ccgggttgtg
     6241 acctcgatac gttcaaaagg tcgggggacc tttttcgcat tgccttcgct ttgccgcgga
     6301 aggccttccg gcctgcgcgg accacagcgc gcagaaattc gaaccatgag gggattcgaa
     6361 tgcgcggaaa aaccaaagtg ctgagcgccg tcacagcgct cgccctgaca gcggcatcgg
     6421 ccgcggcggc cacggccgct ccaccggcgg gaacaacccc gcagaaggcc gccgacgagg
     6481 tcaccctcgt cacgggtgac aaggtcctgc tggggcagga cgggcaggtc gtcgcgatcc
     6541 agccgggcga aggccgcaag aacatgatct tcaagaccgc ccgcagggcg gacggccaca
     6601 cgatggtggt gccgaaggac gccttcgagc ccctggcggc gggccggctc gacagcaggc
     6661 tcttcgacgt caccacgttg ctggagttcg gctaccgcga ccgcatgccg ttgatcgtgg
     6721 acggccgggc cagagtcggg gccaggtcgt cgggcgactg ggcggcgctc aggacggagg
     6781 ccgcgaccgg tgacaagatc tggctcgacg gcatccgcaa gccgagcctc gaccgcagcg
     6841 tcgcccagat cggcgcgccg gccgcccacc agaagggcat caccggcaag gggatcaagg
     6901 tcgcgatcgt cgacacgggt gtcgacgaga agcaccccga cctcgcggga cagcagatcg
     6961 cggagaagaa cttcacgacc gaccccgaca acaccgacaa cgtcggtcac ggcacgcacg
     7021 tcggctcgac cgtcgcgagc cacgactcga agtacggcgg tgtcgcaccg ggcgcgcagc
     7081 tcatcgacgc gaaggtctgc gtcgagttcg gctgccagga gtcctggatc ctcgacggca
     7141 tgcgctgggc ggcggagcag ggcgcccagg tcgtcaacat gagcctcggc ggtggcgaca
     7201 cccccgaggt cgacccgctg gagcaggccg tcaacgacct gacggcccag tacggcacgt
     7261 tgttcgtcat cgcggcgggc aactcgggtt cgaccggttc ggtgagctcc cccagcacgg
     7321 cagaggccgc gctgtcggtc ggtgccgtcg accgcgacga caagctcgcc ccgttctcca
     7381 gcaaaggccc tcgcgtggga gacagcgggc tcaagcccga ggtgaccgca ccgggcgtcg
     7441 acatcgtcgc cgccaaggcc ggcaccagcg accacttggc cggcagcggc acgtcgatgg
     7501 cgactccgca cgtcgccggc gccgcagcac tgctgcgcca gcaacacccg gagtggacgc
     7561 ccgcgcagct caagtcggtg ctcgcgacca cggccaagcc caccgagggc gtcagcgcgt
     7621 tcgaccaggg cgccggacgc atcgacgtgg ccaaggcgat cggccaggtg ctgaccgccg
     7681 acgtcgtggc cgtcaacctc ggcctgcacg agtggccgca cgccgacgac aagccggtga
     7741 ccaagccgat cacctactcc aacccgacgg acgcggcgat cacgctcgac ctcgcgttca
     7801 agggcagcgc tccggcgggc atgttcacgc tgggcgcctc gaagctgacc gtgccggcca
     7861 agggcaccgc gtcggtcacc gtcaccggtg acagccgcgt cggcaccaag gacgccgcgt
     7921 actcgggcga gatcgttgcc acgtccggtc cgcacaccgt ccgcacgctc gtcggcatcg
     7981 accgcgaggt cgagagctac accctctcga tcgacatgat cggccgtgac ggaggggacc
     8041 cggcggactc gttcacgttc atcgccggcc tggacaacga cacgttcaag gcggtgttcg
     8101 gcgcgggcga ccagaagatc cgcctgccca agggcacgta cttcctcgac acgaccctgg
     8161 ggaacggccc acagggcatg gacatgctct accagcccac cgtgaagctg accagcgatc
     8221 agacgatcaa gcaggacgcc cgcctggcgc agccggtgtc ggtgaaggcg ccggaaccgg
     8281 tcggcgactt cgcgatcggg ctgatcgccg tcaaacgctc ggtgggcggc gaaccgcgcc
     8341 tccggtccac ctcggtcatg ttcggcggct tcgacggcgt cgcgatcgcc cagggcggcg
     8401 cccagctccc gccggacgag ttgtcgtcgc tcgcgatgct gcagacgaac gccgcggccg
     8461 acccgcacac gttctaccgg ctcgcctacc ccttcgccgg cggacttccc gtcggcctga
     8521 ccaaggcgcc cgccaagaag gaactggcca gggtcgagtc cacgatcggt ggccagaagc
     8581 cggacagcca ggcgtcgaag ggcgagcttc cgttgtcacc gcagggtttg agcggcggca
     8641 ccgcgctcta cccggtggcc gtcggcgcga ccgcggtcga ctacgtgacg cccgagggtc
     8701 tgcgctggca gtccgcgatc atgacgcggc acgccaacgg cgcgcaggaa cgcatcacct
     8761 ccgggctccg caagtaccag gcgggcaaga cctaccggga acgagaagtc cggccggtgt
     8821 tctcaccggg tctgcccgag tcggagtacg ggttcgtcga gcggtacggc acgcagctct
     8881 acgtcagcgt cccgctggtg agcgacgcca accacggcga cggaaggtcc actgtggaca
     8941 gcgccaggac cgcgttgtac cgcaacggtg tgctgatcgg cgagaccacc acgccgggcg
     9001 ggtcgttctc gaacgtgccg ctgccgcagg ccgacttccg cgccgagatg agcctcgacc
     9061 ggagctcgca gttcgagttc agcaccaggg tgtccgccgt gtggaccttc aagtcgaagg
     9121 gcaccgaggg caagatcgac gctccgccgt tgtcggtggt gcgcttcgaa ccgaagctcg
     9181 acgacaacgg cgcggtgccc gcgggcacgt tgcagcgcat cggactgctc acccagacac
     9241 agggcgacgc gggcaaggtg cgcatcaccg gagtcgagta ctcgcacgac gacggcaagt
     9301 cgtggcgccg tgcgggcgtg gtcggcaaca gcgcgttggt ctacaacccg gcgaacgcgc
     9361 agtggacttc gctgaaggcc actgcgacgg acgccaaggg tggaaccgtc gaactgacgg
     9421 tgatccgcgc ctacaaggtc ggcgcctgat ttctagggca ggttgaggac gagctcggcc
     9481 gccgggacgc gggtgcccgt gtagaagggg atttcctctc gcacgtgcag ccgcgcctcg
     9541 gtgccgcgca ggtgccgcat gaggtcgacg atgcggtgca gctcgtcggc ctcgaacgcg
     9601 agcagccact cgtagtcgcc cagggcgaac gacgcgacgg tgttcgcgcg cacgtccggg
     9661 tagtcgcggg cttccttgcc gtggtccgcc agcatcttgc ggcggtcctc ctccggcagc
     9721 aggtaccact cgtaggaccg cacgaacggg tagacgcaga tgtacttgcg cgcctcttca
     9781 cccgcgagga acgcggggat gtggctgcgg ttgaactcgg ccgggcggtg cagggcgacc
     9841 tgcgaccaga ccggcgtgga gaccttgccg agcggggtgc ggcggaagcc ggtgtaggcg
     9901 gcctgcacct gctcgatctc ctcagcgtgc caccagatca tgaagtccgc gtcggcgcgc
     9961 agaccggcca cgtcgtagac gccgcgcacg acgacgccct tgccctccaa cgcgtccagg
    10021 tagttctggg tctcggcggc agcagccgaa cggtcgtccg gaagcttgcc gggttcgacc
    10081 cggaacaccg accacatcgt gtagcggatg gtgtcgttga gctcgttgta gttcaggcgc
    10141 gccataggtc catcttggca cgggccactc agcgccgaac gcggcccagc aggtgtgctg
    10201 cgacacgggc ggcggccgcg tcggcggtcg cgatgcaggc cggcacaccc accccgtgca
    10261 gggtggcgcc cgcgacggcg aggcccggca cgtcggcgat gccgcgttcg atggtgtcca
    10321 ccaggtcgac gtgaccgacg ccgtactgcg gcagcccccc accccagcgc tggaccacgt
    10381 agtcgatcgg agcggccttg atgcccgtca gctcgtacag gtcgttgcgc acggccttga
    10441 cgaggtcggc gtcgctgcgc tgaaggagcg ccgtctcgcc gtgccgcccg accgagccgc
    10501 gcaggatgac cggttcgccg tagtgcgccc acttgcggct ggagaacgtg aacgccttgg
    10561 cggtgaacgg ggtgatgcgg tcggagtacc gctccccctc cgcgatcagc acgccggagc
    10621 ggtccggcag tgcggtgccc ggtggcagcg ccagcgcgac cacggccatc gaggcgacct
    10681 cgaccttgcc gtacgcggcg gacacctgcg gcgcgatctc gtgcagcagt ctgcgcgcgg
    10741 acggggccgg gaccgcgagc acgacgccgt cgcactccag gtactccggg gtcgcggccg
    10801 aaccgatctc cagccgcca
//
