LOCUS       NZ_FOSG01000006        11947 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces pini strain PL19, whole genome shotgun sequence.
ACCESSION   NZ_FOSG01000006
VERSION     NZ_FOSG01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces pini
  ORGANISM  Streptomyces pini
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900114215.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 02:14:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,762
            CDSs (total)                      :: 5,677
            Genes (coding)                    :: 5,560
            CDSs (with protein)               :: 5,560
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 4, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 3, 6 (16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 117
            CDSs (without protein)            :: 117
            Pseudo Genes (ambiguous residues) :: 0 of 117
            Pseudo Genes (frameshifted)       :: 20 of 117
            Pseudo Genes (incomplete)         :: 111 of 117
            Pseudo Genes (internal stop)      :: 1 of 117
            Pseudo Genes (multiple problems)  :: 15 of 117
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:04:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 314433
            Orig. end                         :: 326380
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOSG01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11947
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11947
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11947
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:6947](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6947)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(154..167)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.68"
                     /tool="antismash"
     gene            complement(739..1353)
                     /locus_tag="BM237_RS11535"
                     /old_locus_tag="SAMN05192584_106286"
     CDS             complement(739..1353)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019979862.1"
                     /locus_tag="BM237_RS11535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05192584_106286"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_093849520.1"
                     /transl_table=11
                     /translation="MSQTVVSIGRDAPFKQIVVTMEQWKVSALPVLEGEGRVVGVVSEA
                     DLLPKEEFRDGDPSRMEQLRRPEELARVGAVTAGELMTSPAVCVHARATLAEAARIMAR
                     RRVKRLPVTDADGLLVGVVSRGDLLKVFLRPDEDIARQVRREVVEPLFPGGDRSVGVRV
                     ADGVVTFTGEIRNTALVPVAARMARSVEGVVDVGFDLGRSA"
     gene            complement(1505..1966)
                     /locus_tag="BM237_RS11540"
                     /old_locus_tag="SAMN05192584_106287"
     CDS             complement(1505..1966)
                     /GO_function="GO:0030551 - cyclic nucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998368.1"
                     /locus_tag="BM237_RS11540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05192584_106287"
                     /product="cyclic nucleotide-binding domain-containing
                     protein"
                     /protein_id="WP_093849471.1"
                     /transl_table=11
                     /translation="MIVTANNLLGALPPENRERLLELAREVSFPAGARISEEGHRADRF
                     WVIRTGSVTLDMRVPGRRPAAVETLSHGDLLGWSWLFPPYTWQLGAEALSPVRALEFDA
                     ARVRQLCEADPVLGRAVALRMAEIISHRLQAARTRLLDLYGPYGSGPMP"
     misc_feature    complement(2268..2278)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            2273..2908
                     /locus_tag="BM237_RS11545"
                     /old_locus_tag="SAMN05192584_106288"
     CDS             2273..2908
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072588.1"
                     /locus_tag="BM237_RS11545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05192584_106288"
                     /product="hypothetical protein"
                     /protein_id="WP_093849472.1"
                     /transl_table=11
                     /translation="MAVHGHTHGHRGFRLPVRRTTRTAPASGETAAATAVVPAASTAAR
                     VLAGVRFATGFVFLWAFADKAFGLGYATPAERAWIEGGSPTKGFLSGVAVGPLESFFHD
                     IAGAAWADWLFMLGLLGIGLALTAGVALRLTAAAGTVMMALMWAAEWPLAQHLSDGSPS
                     MSTNPVVDYHVMYAAVMIALAVAAAGDTWGLGRWWARLPLVRSFPWLR"
     gene            3095..3985
                     /locus_tag="BM237_RS11550"
                     /old_locus_tag="SAMN05192584_106289"
     CDS             3095..3985
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003999669.1"
                     /locus_tag="BM237_RS11550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05192584_106289"
                     /product="universal stress protein"
                     /protein_id="WP_093849473.1"
                     /transl_table=11
                     /translation="MVRTVTVGVDGSAESLAAADWAAREAARRGVPLRLVHVREPDPFT
                     PPDSFADPETRQHWAQRIPREAANDLARRHPELEITTDQLTGRPPEVLTAVAEQAEVLV
                     IGTRGLGPVAGFLVGSVGLATVARVKCPVVLVRAETSKEGEPEGAEPPATPRDVVMGLE
                     LYRPADELIEFGFDAAARRGAALRVIHGWNPPLVYGVDPIAVDPRLATDLAQESSRNLN
                     EALSHWREKYPDVEVKAQAVVGRAARHLTEASEDASLVVVGRRIRRSPIGFHTGPVAHA
                     VMHHSKAPVAVVPFG"
     gene            complement(4202..4789)
                     /locus_tag="BM237_RS11555"
                     /old_locus_tag="SAMN05192584_106290"
     CDS             complement(4202..4789)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357531.1"
                     /locus_tag="BM237_RS11555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05192584_106290"
                     /product="DUF5825 family protein"
                     /protein_id="WP_245793562.1"
                     /transl_table=11
                     /translation="MRMEDVRIEGPVTAAVDRLWESGVRRVRLPGTVDLAATGDPGAAA
                     RAVRDLCLVRDLTARAVFVEWRLRLAPEPSGDWEVLGHLQPPAELEGPNDAAGALARWR
                     EGHYLCKCLWRQGPGFVQIRDRRWGDLRRFTADGPEYHAAITTLAHGARAGDVPAPVLA
                     EFREERLVADVGPLVLWLPYRVRRWIQEAMVI"
     misc_feature    4870..4884
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.34"
                     /tool="antismash"
     gene            complement(5001..6947)
                     /locus_tag="BM237_RS11560"
                     /old_locus_tag="SAMN05192584_106291"
     CDS             complement(5001..6947)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088743.1"
                     /locus_tag="BM237_RS11560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05192584_106291"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_093849475.1"
                     /sec_met_domain="TIGR03975 (E-value: 3e-182, bitscore:
                     601.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLVNMPWSPIDLPSLALGILKRSVDERVPGGRAEVLHANLEF
                     TDWITDRMEFSGDDYEYYALSSYFMGCGDWVFSSALYDDPEWRTEEFTSVMGGKLSSSR
                     LRLTRELHRIAPEFVRETAERIVAYEPDVVGFTSTFQQNTAALAAARQVKLLAPHIVTV
                     MGGANCDAEQGAAVHRNFPFVDHVVRGEGEVAFPRLLTALAEGAEKTEGADLSDIPGLC
                     HRGADGSATANPMSTSPMPPSAILPPDYTGYFERLAASVARNWVEPKLVVEGARGCWWG
                     EKHHCTFCGLNGSFMQFRSKSPEVFHDEIMELARRHRVLDMYVVDNILDMGYLNTVLPR
                     IIDSGYDLRLHIEIKANMRRSQLRTLADAGLIYVQPGIESLNSRVLGLMDKGVSGCQNV
                     RMLRDGAETGLSVSWNYLHGFPGETAADYEGVIAQIPALEHLNPPVDLSARIAIERFSP
                     YFTRPELGFSGLRAEEHYRFTYDLPEEELYDLAYVFKAPARGIGEETVKSLNKALAAWK
                     KAHADSRLTHADLGDRIVLVSRRRLFDWGALELTDPLEIAAFRLLDQPHAPTALTRKLT
                     TRLRHSVEGDAVEGLLKRWLELGLVFAEGGQYVHVAPAAVNEDLLRLDFMRHLHAAPRE
                     GGPTPAARPTAGV"
     gene            complement(7149..9041)
                     /locus_tag="BM237_RS11565"
                     /old_locus_tag="SAMN05192584_106293"
     CDS             complement(7149..9041)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357534.1"
                     /locus_tag="BM237_RS11565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05192584_106293"
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_245793553.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.1e-35, bitscore:
                     117.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTGSSAPDAGRPASGYRVYRPVLPEVCPGDPALMVLTGDAGGR
                     CEVFALDARTGRTRQVTDRPRGTLHCAIDADAAVWWFDEDETGRGRWLHQDFHGGPVRP
                     GLAGLPAGTPRGLAVGAGGTVAVGLGDESGLTVHLGRRGGPGRPAVRTEGHAVLCGLSP
                     DGRLLAVTRSASSDRAVTVHTASGETVAELSGRGGGLWALGFAPAAPGSGGDGGAELLL
                     VRQDGDRYETATWRAGDGVRPHRWCSFDTEITARWYPRGRRILVRQDRRGRSLLFTADL
                     DRQALTPVPVPRGSVLDAVPRPDGDVHYLWTDTATPPHARSASGAPPPAAEAPAVRVPG
                     RHTELWTPGPDGDVHTLLSLPERPAVRPPLVMLVHGGPADHDRDAYDPTVHSLVASGFA
                     VARVNYRGSTGYGPRWRAAYGQGVGLTQVADLVSVRADVLARGLADPGAVGLWGTSWGG
                     YLVLLALGTRPGLWSAGVAVKPLADCATAHRTGTPALRALDEALFGGTPDQVPELYARS
                     SPVHYAHRVRAPLLMAAALHDVKCPPEQVRTYLAALRASGVRHEEMWLDSGHDGYLGGD
                     HVAVLRRALGFLDRELRGAGRTTGRDHDSPSRPGRGQDRPPAPAAGDRVDHERR"
     gene            complement(9038..10273)
                     /locus_tag="BM237_RS11570"
                     /old_locus_tag="SAMN05192584_106294"
     CDS             complement(9038..10273)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088740.1"
                     /locus_tag="BM237_RS11570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05192584_106294"
                     /product="MFS transporter"
                     /protein_id="WP_093849476.1"
                     /transl_table=11
                     /translation="MRLLWWANSADALGTQISGLALPLLLLGLGYSPALVGAVAGASTA
                     LGLLMGPFAAVPADRGARRRVMILCAAVSAAALGSLAAALALGSLHPAHLFAAVLVERV
                     ATSCQEAAARGAVALICPADDHPRVVSRLQAGEQGALVLGPLLGGLLYQAARWLPFLAD
                     ALSYLVAALCVRGMRSDLAPAGTRARDTRPSRARWAAFASEAGAGLGLVLRSPVLRLVL
                     VWTAAAGGLLVALHYTVVFALQGGGRGPAAVGLVFSVAGAAGLAGALAAPAVVRRLTAP
                     RTLVAVSWLVVTPAAALAAGSGPWSYGLLFGAVSLLVPAAVVVLQTRVLRVTPPELLAR
                     TGTALATAAGIAAAVAPLAAGAAVARVGTAPTIAGCAVLLALLAAGTTLAVARGALSAP
                     LPGPDATVKGAL"
     misc_feature    complement(10533..10548)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.99"
                     /tool="antismash"
     misc_feature    10538..10549
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.52"
                     /tool="antismash"
     misc_feature    10580..10595
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            complement(10711..11925)
                     /locus_tag="BM237_RS11575"
                     /old_locus_tag="SAMN05192584_106295"
     CDS             complement(10711..11925)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152855.1"
                     /locus_tag="BM237_RS11575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05192584_106295"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_093849477.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-18, bitscore:
                     61.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.4e-26, bitscore:
                     85.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.3e-50, bitscore:
                     164.0, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGFCLDLTEEQSDLREWVHGFAADVVRPAASEWDEREETPWPVI
                     QEAAKIGLYGFESLADMYGDPSGLSLQIANEELFWGDAGIGMALFGTSLAVAGIFSAGT
                     PDQLAEWVPQCFGDEDDPKVAAFCVSEPEAGSDVSAMRTRARYDEARDEWVISGQKAWI
                     TNGGIANVHVVVASVEPELGARGQAAFIVPPGTSGLESGRKIRKLGLRASHTADVFLDE
                     VRVPGHCLLGGRERLEARLARAREGGQAKGQAAMATFEVSRPTVGAQALGIARAAYEYA
                     LEYAGGRVAFGRPIVENQAVAFALADLRTEIEAVRLLIWQAAWMARNGRAFDAAQGSMS
                     KLRAGELAVAATEKAVQVLGGAGYSREHPVERMYRDAKIYTIFEGTSEIQRLVIARAVS
                     GRHIR"
     misc_feature    complement(11920..11935)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.99"
                     /tool="antismash"
ORIGIN
        1 gcggggcgtc agcgaggcca gcgcggcgtc ctgcggctcc tcgacgggct cctcggtgtc
       61 ctgcacccgc aggctgttca tcagccgcgc cgtggtcgcc gggtccagca tggactgccc
      121 ggaggcgacg gtgcgcacgg cggcgatcag gtccgaaccc ttgatctgct tgaggacgta
      181 gccggaggca ccggccatga tcgcatccag cagggcgtcg tcgtcgtcga acgaggtcag
      241 catcagacag gccagctccg gcatccgcga gcgcagctcg cggcagacgg cgatgccgtt
      301 gccgtctggc aggcgcacgt ccagcacggc cacgtgcgga cgcagggccg gaccgcgcgc
      361 gagggcctgc tcggccgtgc cggcctcgcc gaccacctcg atgtcgggct cggcgtccag
      421 catgtcgtgc acgccgcgcc gcaccacctc gtggtcgtcg aggaggaaca cccggatcgg
      481 gtcctgtggt gagaactgct gggcctgagt catacggatc cttcatgctg tcggtcgggg
      541 gcgccacgcc ccccgcccca tgatcctgcc ccgacccgcc cgtccggcgc cagggcccca
      601 cggccccgcc gcccgcacgc gcggcgggag cccgcgaccg cccgccccgg cacgccggcc
      661 gtgtcgccgg cggtcgcagg tggtctccga gggcaaccgg cggtcgcggg gatcgccggt
      721 ggtcgccggc ggctcacgtc acgcggaccg ccccagatcg aacccgacgt ccaccacccc
      781 ctccaccgac cgcgccatcc gggcggccac cgggaccagg gcggtgttgc ggatctcgcc
      841 ggtgaaggtc accacgccgt ccgccacccg cacccccacg ctccggtcac cgccggggaa
      901 gaggggttcg acgacctccc ggcgcacctg ccgggcgatg tcctcgtccg gccgcaggaa
      961 gaccttcagc aggtctccgc ggctgacgac gccgaccagt aggccgtcgg catcggtcac
     1021 gggcaggcgc ttgacgcgcc ggcgcgccat gatccgcgcc gcctcggcaa gtgtggcgcg
     1081 ggcgtggacg cacaccgccg gcgacgtcat cagctcgccc gcggtcaccg ctcccacccg
     1141 ggccagttcc tccgggcgcc gcaactgctc catgcggctg gggtcgccgt cccggaactc
     1201 ctccttgggc agcagatccg cctcggagac gacgccgacg acgcggccct cgccctccag
     1261 caccggcaga gcgctgactt tccactgctc catggtcacc acgatctgct tgaacggggc
     1321 gtcccgcccg atggagacga cggtctggct catcacgtcg cccacggtgt gcggggcgtg
     1381 cgaggtgccg tccgcgccgt ccgtgctgcc cgcaccgtcc atgctgcctg cgttgtccat
     1441 gttgcccgtg ttgttcatgg ggccctcctc gaagaatcgt ccgccgtgcc gcgccgggcg
     1501 cgcgtcacgg catggggccg ctgccgtagg gcccatacag gtccagcagc cgggtgcggg
     1561 ccgcctgcag ccggtgcgag atgatctcgg ccatccgcag ggccaccgcg cgccccagca
     1621 ccgggtcggc ctcgcacagc tgacgcaccc gggcggcgtc gaactccagg gcccgcaccg
     1681 ggctgagcgc ctcggcgccc aactgccagg tgtagggcgg gaagagccag gaccagccca
     1741 gcaggtcgcc gtgggagagg gtctccaccg ccgcggggcg gcggccgggc acccgcatgt
     1801 cgagggtgac cgagccggtg cggatcaccc agaaccggtc ggcccggtgg ccctcctcgg
     1861 agatacgggc gccggcgggg aaggagacct cgcgggcgag ttccagcagc cgttcgcggt
     1921 tctccggggg cagtgccccg agcaggttgt tggcggtgac gatcatggcg ggcctccctg
     1981 gtgctgagcc gagtgggcgg tgtacgcgcg ggcgtccgct cccggtacgg gcgtcatggc
     2041 ggtccgccgc cgctgtctct actcccgttg tactcccgtg gccggtaagt ggcgcctcac
     2101 cgtcatcgtc ggatttcccg caccgccggg gcaggggccg tacggggacc tcggacggga
     2161 ctttcggccc ccgtgcacgg gcccgcggac ccctgctgcc gcggccgccg ccgcgagacg
     2221 gtgtgaacgt gcccgaacgg cgggccggct ttccgcgaag gggatgagcg acatggcagt
     2281 ccacggccac acgcacggac accgggggtt ccgcctcccg gtgcggcgca ccacccggac
     2341 cgcacccgcg tccggtgaga cggcggccgc gacggccgtg gtgccggcgg cgtcgaccgc
     2401 ggcccgcgtc ctggccgggg tccgcttcgc gaccgggttc gtcttcctgt gggcgttcgc
     2461 ggacaaggcc ttcggcctgg gttacgcgac ccccgccgag cgggcctgga tcgagggggg
     2521 ctcgcccacg aagggcttcc tcagcggtgt ggccgtcggc cccctggagt cgttcttcca
     2581 cgacatcgcc ggagccgcct gggcggactg gctgttcatg ctcggcctgc tgggcatcgg
     2641 cctcgccctg accgccggcg tcgcgctgcg gctcacggcg gccgccggaa ccgtgatgat
     2701 ggcgctgatg tgggccgcgg aatggcccct ggcccagcac ctgtcggacg gcagccccag
     2761 catgtcgacc aacccggtcg tggactacca cgtgatgtac gccgccgtca tgatcgcctt
     2821 ggcggtcgcg gcggcgggcg acacctgggg gctgggccgg tggtgggccc ggctgcccct
     2881 ggtccgcagc ttcccctggc tgcggtgaac ccgccgcccc gcggcggacc accggcccgc
     2941 ggcgcctccg gggcgtcgcg ggccggccgt ctccccgccg tgcgggacgt cagacccgcg
     3001 ggaaagggac cagtgacccc tgccgaacgc gggtactcgg accgatcatg gaaaagaaag
     3061 cggcggagag ccgcctgtca acggaggtgt tgtgatggta cgtacggtca ccgtgggagt
     3121 ggacggctcc gccgagagcc tggccgctgc cgactgggcg gcccgggagg cggcgcggcg
     3181 cggggtgccg ctgcgcctcg tccacgtgcg ggagcccgac cccttcaccc ctccggactc
     3241 cttcgccgac cccgagaccc ggcagcactg ggcccagcgg atcccgcgcg aggcggcgaa
     3301 cgacctcgcc cgccgccacc cggagctgga gatcaccacc gaccagctca ccggccgtcc
     3361 ccccgaggtg ctgaccgcgg tcgccgagca ggccgaggtg ctggtcatcg gcacccgcgg
     3421 cctggggccc gtggccggct tcctggtcgg ctccgtcggc ctggccaccg tcgcccgtgt
     3481 gaagtgcccg gtggtgctgg tgcgggccga gacgtcgaag gagggcgaac cggagggcgc
     3541 ggagcctccc gccacgcccc gcgacgtcgt catgggactg gagctgtacc ggccggccga
     3601 cgagctcatc gagttcggct tcgacgccgc cgcccggcgc ggcgccgcgc tgcgggtcat
     3661 ccacggctgg aacccgccgc tggtctacgg cgtcgacccc atcgccgtcg acccccgcct
     3721 ggccaccgac ctggcccagg agagctcccg caacctgaac gaggcgctga gccactggcg
     3781 ggagaagtac ccggacgtcg aggtgaaggc gcaggccgtg gttggccggg ccgcccgcca
     3841 tctgacggag gcctccgagg acgcctcact ggtcgtcgtc ggccgccgca tccgccgttc
     3901 gccgatcggc ttccacaccg gaccggtcgc ccacgcggtc atgcaccact ccaaggcgcc
     3961 cgtcgccgtc gtcccgttcg gctgacggac acccgccgcc acggccgtgc gcaccaccgg
     4021 gccgcgaccc ttcggcgtcc accgaaaggt cgcggccccg gcatcgccgg gtgggcgcca
     4081 cgccttccgg gcgggcgcac acagtgggac gagcgcggtc gtacggctgg actccccgtt
     4141 ccgccaccgg gccgccctgc cgcaccgggt gccatggtga tctgacggca cctcggcgcc
     4201 gtcagatcac catggcctcc tggatccacc gccgcacccg gtagggcagc cacagcacca
     4261 ggggccccac gtcggccacc aggcgctcct cgcggaactc cgccaggacc ggcgcgggca
     4321 cgtcaccggc gcgggcgccg tgggcgagcg tggtgatggc cgcgtggtac tcgggcccgt
     4381 cggcggtgaa gcggcgcaga tccccccagc ggcggtcgcg tatctgtacg aaacccgggc
     4441 cctgccgcca caggcacttg cacaggtaat gcccctcgcg ccaccgggcc agcgcaccgg
     4501 ccgcgtcgtt cggcccctcc aactcggcgg ggggctggag atgccccagg acctcccagt
     4561 cgccggaggg ctccggggcc agccgcagcc gccactcgac gaacaccgcg cgtgcggtga
     4621 ggtcgcgcac caggcacagg tcgcggacgg cacgggccgc ggcaccggga tcgccggtgg
     4681 cggcgaggtc caccgtgccc ggcagccgca cccggcggac gcccgactcc cacagccggt
     4741 ccaccgcggc cgtgaccggg ccctcgatgc gtacatcctc catgcgcatg ccgggcagcg
     4801 cgcacgcccg cgggtcgtag tcgcgccagg cggcgacggt cagcggcgcc gggccgccgg
     4861 ggtgttccgt gatcgtcgtg ctcactcgtg tcctctccct cgtaggcatg ctcggccgga
     4921 agccggaagc cggaagccgg aagccggaag ccggaagccg gaagccggaa gccggtggtc
     4981 ggtggcggct cgtggacccc tcagacaccg gccgtcggcc gcgccgccgg tgtggggccg
     5041 ccctcccgcg gggcggcgtg cagatggcgc atgaagtcca gcctcagcag atcctcgttg
     5101 accgccgcgg gggccacgtg gacgtactgg ccgccctcgg cgaagaccag gccgagctcc
     5161 agccagcgct tcagcagccc ctccacggcg tccccctcca cggagtggcg cagccgggtg
     5221 gtgagtttgc gggtgagggc cgtgggggcg tgcggctggt ccagcagccg gaaggcggcg
     5281 atctccagcg gatcggtcag ctccagcgcg ccccagtcga acagtctccg gcggctgacc
     5341 agcacgatcc ggtcgcccag gtcggcgtgg gtgagcctgc tgtcggcatg ggccttcttc
     5401 caggcggcca gcgccttgtt gagcgacttc acggtctcct cgccgatgcc gcgcgccggg
     5461 gccttgaaca cataggccag gtcgtacagc tcctcctcgg gcaggtcgta ggtgaagcgg
     5521 tagtgctctt cggcgcgcag cccggagaag ccgagctcgg ggcgggtgaa gtacgggctg
     5581 aaacgctcga tggcgatgcg ggcggacagg tcgaccggcg ggttcaggtg ctccagcgcc
     5641 ggtatctggg cgatgacccc ctcgtagtcg gcggccgtct cgccggggaa gccgtggagg
     5701 tagttccagg agaccgacag gccggtctcg gcgccgtccc gcagcatccg gacgttctgg
     5761 cagccgctga cccccttgtc catcagcccc agcacacggc tgttgaggct ctcgatgccc
     5821 ggctggacgt agatcaggcc cgcgtccgcg agggtgcgca gctgggagcg gcgcatgttc
     5881 gccttgatct cgatgtgcag ccgcaggtcg tacccgctgt cgatgatgcg gggcagcacc
     5941 gtgttgaggt agcccatgtc gaggatgttg tcgacgacgt acatgtccag cacccggtgc
     6001 cggcgggcca gctccatgat ctcgtcgtgg aagacctccg ggctcttgct gcggaactgc
     6061 atgaacgagc cgttgagccc gcagaaggtg cagtggtgct tctcgcccca ccagcagccg
     6121 cgggccccct cgacgacgag cttgggctcc acccagttgc gggccacgga ggcggccagc
     6181 cgctcgaagt agccggtgta gtcgggcggc aggatggcgg acgggggcat cggcgaggtg
     6241 ctcatcgggt tggcggtggc ggatccgtcc gccccccggt ggcacagccc cggtatgtcc
     6301 gacagatcgg ccccctccgt cttctcggcg ccctcggcca gcgccgtcag cagccggggg
     6361 aaggccacct cgccctcgcc gcgcaccacg tggtccacga acgggaagtt gcggtggacg
     6421 gcggcgccct gctcggcgtc gcagttggcg ccgcccatga cggtcacgat gtgcggggcc
     6481 agcagcttga cctgccgggc ggcggccagc gcggcggtgt tctgctggaa ggtggaggtg
     6541 aagccgacca cgtccggttc gtacgccacg atccgctcgg cggtctcccg gacgaactcc
     6601 ggcgcgatcc ggtgcagttc acgtgtcagc cgcagacggg aggagctcag cttcccgccc
     6661 atcacggagg tgaactcctc ggtccgccac tcggggtcgt cgtagagcgc ggaggagaag
     6721 acccagtcgc cgcatcccat gaagtaggag gacagggcgt agtactcgta gtcgtccccg
     6781 gagaactcca tgcggtcggt gatccagtcg gtgaactcca ggttggcgtg cagcacctcg
     6841 gcccggccac cgggaacccg ctcgtccacg ctgcgtttga ggatgccgag cgccagggac
     6901 ggcagatcga tcggtgacca gggcatgttg acaagaagga cgcgcatggc agctcctcgg
     6961 aacggaagat gtggccggaa gcggccgccc ggcccggcgg tgagggccgg accgggcggt
     7021 gaggagtcac tcctcctcgg tgtcctccgc ggtgcggagc gggatggtga cggtgacgcc
     7081 gacggtgggc ttgcggttct cttcgtcgcc cgcgagcggg tcgttgttga tgacgtcctt
     7141 ctgcatggct acctcctctc gtggtccact cggtccccgg ccgccggtgc cggcggccgg
     7201 tcctgccccc gccccggccg ggacggggag tcgtgatcac ggccggtcgt ccggccggcg
     7261 ccgcgcagct cccggtccag aaagcccagg gcccggcgca gcacggcgac gtggtcgccg
     7321 ccgaggtagc cgtcgtggcc ggagtccagc cacatctcct cgtggcgcac ccccgaggcg
     7381 cgcagcgccg ccaggtacgt gcgcacctgt tcgggcgggc acttgacgtc gtggagggct
     7441 gcggccatca gcagcggcgc ccgcacccgg tgcgcgtagt ggacggggga gctgcgcgcg
     7501 tagagctcgg gcacctgatc gggggtgccg ccgaacagcg cctcgtccag ggcgcgcagg
     7561 gccggcgtac cggtgcggtg ggcggtggcg cagtcggcca gcggcttgac ggccaccccc
     7621 gcgctccaca ggccgggccg ggtgcccagc gccagcagga cgaggtaacc gccccaggag
     7681 gtgccccaca ggcccaccgc accgggatcg gccagcccgc gcgccagtac gtcggcccgg
     7741 accgagacga ggtcggcgac ctgggtcagg cccaccccct gaccgtaggc cgcgcgccag
     7801 cggggcccgt agccggtgga gccgcggtag ttgacccggg ccacggcgaa gcccgaggcg
     7861 accagcgagt gcacggtcgg gtcgtaggcg tcccggtcgt ggtcggcggg gccgccgtgg
     7921 acgagcatca ccagcggcgg acggacggcg ggacgttcgg ggaggctgag cagggtgtgt
     7981 acgtccccgt ccggcccggg cgtccacagt tcggtgtgcc gtccgggcac ccggacggcg
     8041 ggcgcttccg cggccggcgg cggggcgccg gaggcggaac gggcgtgcgg cggggtggcg
     8101 gtgtcggtcc acaggtagtg cacgtccccg tccggccggg gcacggcgtc cagaacgctg
     8161 ccgcggggca ccggcacggg ggtcagggcc tgccggtcca ggtcggcggt gaacagcagg
     8221 ctgcggccgc ggcggtcctg gcgtaccagg atccggcgcc cccgggggta ccagcgggcg
     8281 gtgatctcgg tgtcgaagga gcaccaccgg tgcgggcgca ccccgtcccc ggcacgccag
     8341 gtggcggtct cgtagcggtc gccgtcctgc cgcaccagca gcagctccgc cccgccgtcc
     8401 ccgccgctgc cgggtgcggc gggtgcgaaa cccaacgccc acagcccgcc gccccggccg
     8461 gagagctcgg ccaccgtttc gccggaggcg gtgtggacgg tgacggcccg gtccgaggac
     8521 gccgaccggg tgacggccag cagccggccg tccggggaga gcccgcacag gaccgcgtgc
     8581 ccctccgttc gcacggccgg ccggcccggg ccgccgcgcc ggccgagatg gaccgtcaga
     8641 ccgctttcgt cgccgagtcc gacggcgacc gtcccgccgg cgccgaccgc cagcccgcgc
     8701 ggggtcccgg cgggcaggcc ggccaggccg ggccgtacgg gaccgccgtg gaagtcctgg
     8761 tggagccagc ggccgcgacc ggtctcgtcc tcgtcgaacc accagacggc ggcgtcggcg
     8821 tcgatggcgc agtgcagggt gccgcgcggg cggtcggtga cctgccgggt gcggccggta
     8881 cgggcgtcga gggcgaagac ctcgcagcgg ccgccggcgt cgccggtgag caccatcagc
     8941 gccgggtcgc cggggcagac ctccggcagc accggccggt agacgcggta accggatgcg
     9001 gggcggcccg cgtccggcgc ggaggagccg gtcgtgctca cagtgccccc ttcaccgtcg
     9061 cgtccggccc gggcaggggc gcggacaggg cgccgcgggc caccgccagg gtggtgcccg
     9121 cggcgagcag ggccagcagc accgcacacc ccgcgatcgt cggcgcggtt ccgacccggg
     9181 ccacggccgc cccggcggcg aggggcgcca ccgccgcggc gatccccgcc gcggtggcca
     9241 gcgccgttcc ggtgcgggcc agcagctcgg gcggcgtcac ccgcagcacc cgggtctgga
     9301 gcaccaccac ggcggccggg accagcaggg agacggcgcc gaacagcagc ccgtacgacc
     9361 aggggccgct tccggccgcc agtgcggcgg cgggcgtcac caccagccac gagaccgcca
     9421 ccagcgtccg cggcgcggtc agccgccgga ccacggcggg tgcggccagt gccccggcga
     9481 ggccggccgc gcccgcgacg gagaacacca gccccacggc ggccgggccc cgtccgccgc
     9541 cctggagtgc gaagacgacc gtgtagtgga gcgcgaccag cagcccgccg gcggcggccg
     9601 tccacaccag caccaggcgc agtacggggg agcgcaggac caggccgagg cccgctcccg
     9661 cctcggaggc gaaggccgcc caccgggccc gcgaggggcg tgtgtcccgc gcccgtgtcc
     9721 ccgccggagc gaggtccgag cgcatgccgc gcacgcacag cgcggcgacg aggtaggaca
     9781 gggcgtccgc caggaacggc agccaccggg cggcctggta gagcagcccg cccagcagcg
     9841 gccccagcac cagggcgccc tgctcgccgg cctggagccg cgagaccacc ctcgggtggt
     9901 cgtccgcggg gcagatcagg gccacggcgc cgcgggccgc cgcctcctgg caggaggtcg
     9961 cgacgcgctc gacgaggacc gcggcgaaca ggtgcgccgg atggagggag cccagtgcca
    10021 gggccgcggc gagcgacccc agcgcggcgg cggacaccgc ggcgcagagg atcatcacgc
    10081 ggcggcgggc gccccggtcg gcgggcacgg cggcgaacgg gcccatcagc agccccagtg
    10141 cggtggaggc ccccgcgacc gctccgacga gggcggggga gtaccccagg cccagcagga
    10201 gcagggggag ggcgagaccg gagatctggg tgcccagggc gtcggcgctg ttggcccacc
    10261 acagcagccg cacgtcgcgg cgcggggctg gagcccggtg cccgccggcc gccgggccgg
    10321 cggccccggt ccgcctcacc gggcgggccg ggggcgcggc gtggggcgcg gcgtgggaag
    10381 cagcgcggga aaccgtgcgg aaagccgtgc gcccaagcgg gtcaacgcgg gtaaggcact
    10441 cgtctccggt aacgccggtc ctcgttccac gcgcagccct tccactcgat ctccacgcgg
    10501 tgtccgtgaa ggtcggatcc gatggtcgac atgcgaagaa aacgtgtgcg aatcacagcg
    10561 gacgggagtc taatcacgag gtgacgcggg tcacaagagg cctgtgggaa aggcgagttg
    10621 gggccgcgga acggaacgcg tcggtccgcg ccccgggtgg ccgggagcgc ggacggacgg
    10681 tgcgggggag cggtgggagc cggcgccgcg tcagcggatg tggcggccgg agaccgcgcg
    10741 ggcgatcacc aggcgctgga tctcgctggt gccctcgaag atggtgtaga tcttggcgtc
    10801 ccggtacatt cgctccaccg gatgctcccg gctgtacccg gcgccgccga ggacctgtac
    10861 ggccttctcg gtggcggcga cggccagttc gccggcgcgc agcttggaca tcgacccctg
    10921 ggccgcgtcg aaggcgcggc cgttgcgggc catccaggcc gcctgccaga tcagcagacg
    10981 gacggcctcg atctcggtcc gcagatcggc cagggcgaag gcgacggcct ggttctcgac
    11041 gatggggcgg ccgaaggcga cgcggccgcc cgcgtactcc agggcgtact cgtaggcggc
    11101 gcgcgcgatg ccgagcgcct gagcgcccac ggtgggccgg ctgacctcga aggtcgccat
    11161 ggcggcctgc cccttggcct gtccgccctc gcgggcgcgg gccaggcgcg cctccagcct
    11221 ctccctgccg cccagcaggc agtggcccgg cacccgcacc tcgtccagga agacatcggc
    11281 cgtgtgcgac gcccgcaggc ccagcttcct gatcttgcgg ccggactcca ggccggatgt
    11341 gccgggcggg acgatgaacg ccgcctggcc gcgtgcgccg agctccggct ccaccgaggc
    11401 caccaccacg tgcacgttcg cgatgccgcc gttggtgatc caggccttct ggccgctgat
    11461 cacccactcg tccctcgcct cgtcgtaccg ggcgcgggtg cgcatggccg agacgtcgga
    11521 gccggcctcg ggctcggaga cgcagaaggc cgccaccttg gggtcgtcct cgtcgccgaa
    11581 gcactgcggg acccactcgg cgagctggtc gggggtgccg gcggagaaga tgcccgccac
    11641 cgccagcgag gtgccgaaca gggccatgcc gatgccggcg tcgccccaga acagctcctc
    11701 gttggcgatc tggagggaca ggcccgaggg gtcgccgtac atgtcggcca gggactcgaa
    11761 gccgtacagg ccgatcttcg ccgcctcctg tatgacgggc caaggggtct cctcccgctc
    11821 gtcccactcg gaggcggccg ggcgcacgac gtcggcggcg aaaccgtgca cccactcgcg
    11881 caggtcgctc tgctcctcgg tgaggtcgag gcagaaaccg ctcatgatcc gcgttcgctc
    11941 ctcatgc
//
