LOCUS       NZ_FOZB01000006        21623 bp    DNA     linear   CON 28-FEB-2024
DEFINITION  Pseudobutyrivibrio sp. NOR37, whole genome shotgun sequence.
ACCESSION   NZ_FOZB01000006
VERSION     NZ_FOZB01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Pseudobutyrivibrio sp. NOR37
  ORGANISM  Pseudobutyrivibrio sp. NOR37
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Pseudobutyrivibrio.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/28/2024 14:17:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,726
            CDSs (total)                      :: 2,671
            Genes (coding)                    :: 2,662
            CDSs (with protein)               :: 2,662
            Genes (RNA)                       :: 55
            rRNAs                             :: 1, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 4, 3 (16S, 23S)
            tRNAs                             :: 43
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 9
            CDSs (without protein)            :: 9
            Pseudo Genes (ambiguous residues) :: 0 of 9
            Pseudo Genes (frameshifted)       :: 3 of 9
            Pseudo Genes (incomplete)         :: 8 of 9
            Pseudo Genes (internal stop)      :: 0 of 9
            Pseudo Genes (multiple problems)  :: 2 of 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:29:30
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 16352
            Orig. end                         :: 37975
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOZB01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21623
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21623
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21623
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11623](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11623
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    811..822
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.11"
                     /tool="antismash"
     misc_feature    1042..1059
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: strong, score: 20.62"
                     /tool="antismash"
     misc_feature    1053..1070
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: strong, score: 20.62"
                     /tool="antismash"
     gene            1105..1500
                     /locus_tag="BM306_RS12370"
                     /old_locus_tag="SAMN04487829_2488"
     CDS             1105..1500
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="BM306_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2488"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_163927073.1"
                     /transl_table=11
                     /translation="MNKAEEPVFEALELSNLVGDCISKLDGEAKEANISLSFSGERCSV
                     FGSKENLEEVVFNLVENSIKYNDEGGHIWVKVYTSDGPTISIKDDGKGTPYADPIITSV
                     KDIVELHQAKLITDNGIGGGSEFKVVF"
     gene            1574..2248
                     /gene="hypB"
                     /locus_tag="BM306_RS12375"
                     /old_locus_tag="SAMN04487829_2489"
     CDS             1574..2248
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0016530 - metallochaperone activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hypB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007887787.1"
                     /locus_tag="BM306_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2489"
                     /product="hydrogenase nickel incorporation protein HypB"
                     /protein_id="WP_090489596.1"
                     /transl_table=11
                     /translation="MSEVKVIEIGESVFAENEAAAASIREQMKKQGTFFVNVMSGPGSG
                     KTTTLSAIINRMKDKYKIGEMDVDIETSIDAQRVADATGVESIQIHNMGLCHIDADMTS
                     RALSEYDTTGLDLLILENIGNLVCPAEFDVGANKNLMLLSVPEGDDKPLKYPLMFEVSD
                     VVLINKIDTLDYFDFSKEKVTERILKLNPNAKIFFVSGKTGEGLDAVVDWLESEIAAVK
                     QA"
     gene            2265..2522
                     /locus_tag="BM306_RS12380"
                     /old_locus_tag="SAMN04487829_2490"
     CDS             2265..2522
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM306_RS12380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN04487829_2490"
                     /product="hypothetical protein"
                     /protein_id="WP_090153421.1"
                     /transl_table=11
                     /translation="MKENHGELNMSVSAVCQNDKGQKYAFVTFSDGVRDAEGRIPECKI
                     LNNNGFAAIEVNELEKYMREHLSDLKKMAAGIDIFSAFTK"
     gene            2609..4324
                     /gene="ade"
                     /locus_tag="BM306_RS12385"
                     /old_locus_tag="SAMN04487829_2491"
     CDS             2609..4324
                     /EC_number="3.5.4.2"
                     /GO_function="GO:0000034 - adenine deaminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006168 - adenine salvage [Evidence IEA]"
                     /codon_start=1
                     /gene="ade"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002570711.1"
                     /locus_tag="BM306_RS12385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2491"
                     /product="adenine deaminase"
                     /protein_id="WP_242941885.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 8.6e-36, bitscore:
                     117.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYKQKSMTRDEYEYFLQVTAGEVKAELVLKNANFLDVFTNRFKS
                     GDIAISSGTFAGIGKYSGAQEIDMTGKTIVPGFIDAHIHIESTTVVPEIFVKESIKHGT
                     TAVITDPHEIANVMGVDGINYMLEATEGLPMDVFFMIPSCVPSCKYDEAGAVIMASDME
                     QFYGRDRVKGMAELMDVDGVVSRNPSVLDKSYSAIKKDMLIDGHAPMVTGRKLVSYIAA
                     GVLSDHECASLEEALEKMGLGVWIMIREGTAAQNLADLIGLCQEPYASRSMFCTDDRHI
                     NHIMDEGHIDAIIRKAIKLGADPAIAYKMASYNAAAYFGLRDRGAISPGFLADFIVLED
                     INDARVGAVYKNGIEITDEALKLKCKSHITDDLIEKSHDTFHLPFITEEMLGNKGKLPI
                     IGLVPGQLYTTREGLSDGINIDQDILKVAVVERHNNTGHIGIGFVNGYGMKKGAIATSV
                     AHDAHNIIAIGASEKDMAHAINALKDIGGGMVVWADGKVKASYPLPVAGLMSEESSDMT
                     KKHLEEIHLAAYELGANKDIDPFMTLSFTALPVIPELRITTKGVVDVASGKIFK"
     gene            complement(4363..5928)
                     /locus_tag="BM306_RS12390"
                     /old_locus_tag="SAMN04487829_2492"
     CDS             complement(4363..5928)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040163.3"
                     /locus_tag="BM306_RS12390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2492"
                     /product="DUF5722 domain-containing protein"
                     /protein_id="WP_143096676.1"
                     /transl_table=11
                     /translation="MKVLKSLASLALSLALVITAFAMVPPVDAKAAGSVAIGSVLIQGS
                     DVVIATTGATGSDDGLFHLVASDVNESAPVGIDVAQAPAASGTTFSVPLNKGAAESVLF
                     KKFTVCVMSGGALKPVSNSMFILNPEAAAQAGARRMDRSKKGILPALEGYQLGKCQPKD
                     LGCTQVNLTLPLSWITGGSGIPWNYNGKTYNFETARLSAYDISLKKFNEQGCQVSVIIV
                     VDAAADGRFISPYSMDQLGLHNYYGLNASTKEGVELLAAASSYLANRWCGRGYGQVDNF
                     IIGNEVNAYTMWNYMNCGSHEAFVREYANAFRVIYNGIKSENSTANVYTCIDHQWARPE
                     AGYYMSGKGFLSSFNSYIKSQGNIDWRLAHHPYNSQLSDPCAWLGAGAPHSQSAPYVTV
                     YNFDVLTDYLSTPDLLSPSGAVRSVKISEVGYTSAYGQEQQAASIVYAYLVAMNNRFVD
                     GIVLSRETDHTDEIAQGLAYGICNVDASRKMAYSWYQSADNPNTIAQASAIAGVDLMSR
                     ITPR"
     misc_feature    complement(5904..5920)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.51"
                     /tool="antismash"
     gene            complement(6049..7524)
                     /gene="malQ"
                     /locus_tag="BM306_RS12395"
                     /old_locus_tag="SAMN04487829_2493"
     CDS             complement(6049..7524)
                     /EC_number="2.4.1.25"
                     /GO_function="GO:0004134 - 4-alpha-glucanotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005980 - glycogen catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="malQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015548714.1"
                     /locus_tag="BM306_RS12395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2493"
                     /product="4-alpha-glucanotransferase"
                     /protein_id="WP_090489797.1"
                     /transl_table=11
                     /translation="MKRSSGILFPISSLPSPYGIGTFGKAAYEFADFLKAAGQKYWQVL
                     PLGPTSYGDSPYQSFSTNAGNPYFIDLDMLIEDGLLTKEDVKKEKWGTNPRYVDYGQIY
                     ISRFKVLEKAKERGYKSLINEIGAFVDDNPWVENYALFMALKKHFNMISWQEWPEEDIR
                     LHDKDAVLKYKMELSDDMEFYIFIQYLFFKQWDKLKKYINDLGIEIIGDLPIYVALDSC
                     DVWAEPEFFSLDDKNYPVEVAGVPPDYFSADGQLWGNPCYNWDAMKKDGYRWWLRRIEG
                     AVKLYDVLRIDHFRGFDEYWAVPAGESTAKNGQWKPGPGMDLVGLLSSTFPKTEFIAED
                     LGQPSPTVVKLLNDSKWPGMKVLEFAFDSGEANNYQPHTYDKNCICYTGTHDNATVMEW
                     YQTAKKADRKYAKEYLGISRFEKFNWGMIRGGMSSVAVLFVAQMQDYLGLGKFNRINVP
                     GTKSGNWQWRLLKNELSDELAEKILQLVHMYER"
     gene            complement(7549..8553)
                     /locus_tag="BM306_RS12400"
                     /old_locus_tag="SAMN04487829_2494"
     CDS             complement(7549..8553)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012742.4"
                     /locus_tag="BM306_RS12400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2494"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_090489600.1"
                     /transl_table=11
                     /translation="MTIKDIARLAGVSVSTVSRVLNNHPDVSQDAVKKVMAIVNKYNYI
                     PNTSARNLGMSSSDNIGVIMRGISNPFYTKIITAIGDKIEKSGYTMVMQQISTDEDELR
                     VAAMMEKDKRLQGLILLGGHLNYTKEQVSSIGVPFVCCTFSNEYGNLNSDQYSSVCIDD
                     EATAFSAVEQLYKKGHKKIAVLLSAVDDGSVSQVRYAGYKRALKDFNIPEDDNLIIQIH
                     SFNIADAYHEMSKWLDKGIDFSALFCISDNMAMGAMKALRDAKKIVPDDVAVIAIDGIE
                     ASEYTNPVLSTLCQPMEHIGIKAVDVLVDIINNEGQHQHLTLPTTLREGETLR"
     gene            8737..9912
                     /locus_tag="BM306_RS12405"
                     /old_locus_tag="SAMN04487829_2495"
     CDS             8737..9912
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017509.4"
                     /locus_tag="BM306_RS12405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2495"
                     /product="FKBP-type peptidyl-prolyl cis-trans isomerase"
                     /protein_id="WP_090489602.1"
                     /transl_table=11
                     /translation="MKKKLFTVLLCGALAVSAVACKKEIKYKASDLVELGQYKGMEITL
                     NNNYEYTEEGFDAFVENSIQQLGIFIPDDSLTTVEEDSIVNVDYVGSKDGVAFDGGSAE
                     DQMIDIANNSSATQKTGYIAGFTAGLVGHEVGEEVAYEVTFPEQYNSPDLAGQTVVFTF
                     QINYIANAIDSKDKLTDDLVAEKIPDYTTVDEYLAALEEKYKDNLETALESDKETAILN
                     SISNGNIGTVEKVPEDLLQARVDMIINMQEKQYEAMGTTMEEYATSAGYDYEETIATLK
                     KNLEESTKTEIILEAIADAENIQIDDGYKEFVKNIYTQMKYNNAEELYSDFSVEGYDGR
                     RYFELAYRTEKALDYLVENCVVSFEEPPLVEDVEVTDDEAVQEDATEESAE"
     misc_feature    9975..9988
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.35"
                     /tool="antismash"
     gene            10001..10144
                     /gene="scfA"
                     /locus_tag="BM306_RS12410"
                     /old_locus_tag="SAMN04487829_2496"
     CDS             10001..10144
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015524633.1"
                     /locus_tag="BM306_RS12410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2496"
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_033151787.1"
                     /sec_met_domain="TIGR03973 (E-value: 6.6e-27, bitscore:
                     86.6, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 7.1e-27, bitscore: 86.5,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKRLQNTVKEGGCGECQTSCQSACKTSCTVGNQSCEH
                     KN"
     aSDomain        10247..10549
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BM306_RS12415_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="1.10E-32"
                     /identifier="RREFam024.1"
                     /label="BM306_RS12415"
                     /locus_tag="BM306_RS12415"
                     /protein_end="101"
                     /protein_start="0"
                     /score="103.2"
                     /tool="antismash"
                     /translation="MIHQFKNNGYNVVIDVNSGAIHVVDEVTYDFLAFWQKQGGDAALA
                     SMKESHSEVSEAELLQIKSEIESLIEDKSLFTEDNYEPRIADFTARPTVVKALCLH"
     gene            10247..11623
                     /gene="scfB"
                     /locus_tag="BM306_RS12415"
                     /old_locus_tag="SAMN04487829_2497"
     CDS             10247..11623
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006856452.1"
                     /locus_tag="BM306_RS12415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2497"
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_090489603.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 6.4e-32,
                     bitscore: 103.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.4e-74, bitscore:
                     244.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.1e-14, bitscore: 45.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4e-13, bitscore: 43.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1e-17, bitscore: 57.7,
                     seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQFKNNGYNVVIDVNSGAIHVVDEVTYDFLAFWQKQGGDAALA
                     SMKESHSEVSEAELLQIKSEIESLIEDKSLFTEDNYEPRIADFTARPTVVKALCLHITH
                     DCNLACKYCFAEEGEYHTGKRELMTFEVGKQALDFLVANSGSRRNLEVDFFGGEPLMNW
                     QVVKDLVAYGRSIEKEHDKNFRFTLTTNGVLLNDEIQEFANKEMANVVLSCDGRPEIHN
                     LMRPFKKGAPSYELIMPKFKKLAESRNQDKYYIRGTFTRNNLDFSEDVIHLANEGFKQI
                     SVEPVVAQETDDYAIREEDLPKLFEEYDKLAAEMMRRKGTEEDFNFFHFMIDLEGGPCV
                     YKRLSGCGSGTEYMAVTPTGELYPCHQFVGNTDFCLGDVWHGVQKKDVVNEFKHCNVYA
                     KPECRECFARFYCSGGCAANAFNFTGSILGNYHVGCELQKKRVECAIALKVKEAEIKGE
                     "
     gene            11672..14020
                     /gene="secD"
                     /locus_tag="BM306_RS12420"
                     /old_locus_tag="SAMN04487829_2498"
     CDS             11672..14020
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015516876.1"
                     /locus_tag="BM306_RS12420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2498"
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_090489605.1"
                     /transl_table=11
                     /translation="MKRLKKGQGIAWLIAFVLCLGLLGYYAMTVVQGTIKANDTSLKLG
                     ADATDAQKAKMAKYNADSLKLGLDLDGGVSITYEAIGDKPTDEQMNDTILKLQQRIEND
                     LGEESSTTEANVYRVGDKRITVEIPGVTDANALLKELGTPGTLYFIMQYDDQGNANYTT
                     TGRDENGDIQGTLNYDIQTLIDNGSVIATGKNVRSSQAGTDQDKTTGATEYVVELKFDD
                     AGTKAFADATSKAYANGWSIAIYYDGKFVSVPTVQAAITDGNCVINGMSDYAEAEKLAS
                     YIRIGGLDIELQELESQVVGAQLGSDALKTSLIAGGIGLLVVMLFLIVMYLVPGVVASL
                     ALALYTVMLVSILKAFDITLTLPGIAGMILSIGMAVDANVICFARVREEIKAGRPVISA
                     IETGFSKALSAILDGNITTLIAAAVLGFLGSGSVKGFAITLALGVILSMFTALVITRIL
                     INAFYAIGIRNAKAYGKAKEPTKFDFVGKKAIFIGISVFIIAAGFISMGVFKAKNGSGL
                     NYSLEFMGGASTTVDFAAPQTDDVINNQIIPDIQKVIGDGTVQKSTVDGTNQVIFKTRT
                     LSLDERTALNTMLETNYGVTEESITSQNIGSTISGEMRSQSMIAVIVAVFFMLLYIWFR
                     FKDLRFASSAIIALVHDVLIVLSLYAFARISVGAAFIACMLTVIGYSVNDTIVVFDRIR
                     ENHKAIRTETPETLKELCNESLSQTLSRSISTSITTAIMVLMLLILGVSSIREFALPLL
                     AGVIAGTYSSIFIATQLWYIFKCKIGKKN"
     gene            14045..15334
                     /gene="serS"
                     /locus_tag="BM306_RS12425"
                     /old_locus_tag="SAMN04487829_2499"
     CDS             14045..15334
                     /EC_number="6.1.1.11"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004828 - serine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006434 - seryl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="serS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006855678.1"
                     /locus_tag="BM306_RS12425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2499"
                     /product="serine--tRNA ligase"
                     /protein_id="WP_090153435.1"
                     /transl_table=11
                     /translation="MIDIKFLRENPDAVKENIKKKFQEHKLGLVDEVIELDDKRRAAQQ
                     EADDMRAKMNQAAKQIGALMGQGKKDEAEAVKAEVADLKQKIKDLEPVEKELADKVEEI
                     MMKIPNIIDPSVPIGPDDSCNVEIEKFGEPVVPDFEIPYHTDIMERFNGIDMDAAGKVA
                     GNGFYYLMGDIARLHSAVISYARDFMIDRGFTYCIPPFMIRSNVVTGVMSFEEMDAMMY
                     KIEGEDLYLIGTSEHSMIGKFIDTLNDEANLPYTLTSYSPCFRKEKGAHGIEERGVYRI
                     HQFEKQEMIVVCKPEESKKYYDVLWKNTVDLFRSLDIPVRTLECCSGDLADLKVKSCDV
                     EAWSPRQKKYFEVGSCSNLGDAQARRLKIRVKGADGSKYFAHTLNNTVVAPPRMLIAFL
                     ENNLREDGSVAIPEALRPYMGGKEVLVPIK"
     gene            15625..17457
                     /gene="typA"
                     /locus_tag="BM306_RS12430"
                     /old_locus_tag="SAMN04487829_2500"
     CDS             15625..17457
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /GO_process="GO:0006950 - response to stress [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="typA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015548730.1"
                     /locus_tag="BM306_RS12430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2500"
                     /product="translational GTPase TypA"
                     /protein_id="WP_090153437.1"
                     /transl_table=11
                     /translation="MAVQSREDIRNIAIIAHVDHGKTTLVDELLKQSGVFRENQEVAER
                     VMDSNDIERERGITILSKNTAVYYKDTKINIIDTPGHADFGGEVERVLKMVNGVVLVVD
                     AFEGAMPQTKFVLMKALDLDLPVIVCINKIDRPEARPDEVIDEVLELFMDLDASDEQLD
                     CPFIYASAKEGFAIKNLSDEHKDMTALFETIIDYIPAPTGDPEAPTQVLISTIDYNEYV
                     GRIGIGKVENGSIKVNQDAVVVNAHDPEKNNKVRISKLFEYDGLEKVDVNEANIGSIVA
                     ISGIADIHIGDTICAVDAPNPIPFQKISEPTISMNFIVNDSPLAGQEGKYVTSRHIRER
                     LMKELNTDVSLRVEDTDSPDSLKVSGRGELHLSVLIENMRREGFEFAVSKAEVLYKTDE
                     KGHKLEPMERAYVDVPDEFTGAVIEKLSQRKGELQNMTPITGGFTRIEFKIPSRGLIGY
                     RGEFMTDTKGNGIINTIFDGYEIYKGDIAYRKQGSLIAFETGESVTYGLFSAQERGTLF
                     IGPGEKVYSGMVIGQSSRAEDIELNVCKKKHLTNTRSSSADEALTLVPPRILSLEQALD
                     FIDVDELLEVTPESLRIRKRILDPLMRKRAGIRK"
     gene            17476..18624
                     /locus_tag="BM306_RS12435"
                     /old_locus_tag="SAMN04487829_2501"
     CDS             17476..18624
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013180.4"
                     /locus_tag="BM306_RS12435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2501"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_090489607.1"
                     /transl_table=11
                     /translation="MENVLGIDGGTYIGFLTCVGMLLFIIAMRSFDPKLRTQFIKLVVA
                     VMISLAAAAVDMYLDTLAEPLAIRYLVKNVKYITQGLSEYFVLLIIIRDHTNLNKKLLL
                     IPFVIASVVVCLAPFSSRIYSFTADNQFIRGPIGNIIFIQAASYIVVTLLACIHKWFDG
                     YQNDATVILFMLFAVCVGVILEEEKIFPNCTMESSIVGVVFLYIYIYAERYNVDSVSRC
                     YKRRCFYSDANRYSKLDMMIISMDLNDLKLINDNYGHKAGDIALLTFAEVVRSVKTNKF
                     ILYRTGGDEFMILGIKATEDEAKELVELVKEKLTETPYTCSFGIYPYKPGDDFDAAVVR
                     ADKAMYEDKSAYKASKSKRSHSRSDEFESRLETFTNNISFLG"
     gene            18633..19394
                     /gene="dapB"
                     /locus_tag="BM306_RS12440"
                     /old_locus_tag="SAMN04487829_2502"
     CDS             18633..19394
                     /EC_number="1.17.1.8"
                     /GO_function="GO:0008839 - 4-hydroxy-tetrahydrodipicolinate
                     reductase [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="dapB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012743356.1"
                     /locus_tag="BM306_RS12440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2502"
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="WP_090489610.1"
                     /transl_table=11
                     /translation="MTRVVMHGCNGHMGRVITDICAADADVEIVAGVDKFKGIDNSYPV
                     YDSIAEVKENFDAIIDFSNVAAIDGLLDYCVANNKPVILCTTGLTDDMLKHVDEACKSV
                     PVLRSANMSLGINTLFDLCKKATKVFADAGFDIEIVEKHHNQKLDAPSGTALALADACN
                     EALGNEYEYCYGRADRREKRPVKEIGISAVRGGNIVGEHEVIFAGLDEVITIKHTAYSK
                     SVFAKGAVEAAKYIVGQPAGLYDMKKVISNK"
     gene            19418..20077
                     /locus_tag="BM306_RS12445"
                     /old_locus_tag="SAMN04487829_2503"
     CDS             19418..20077
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (19-121). E-value:
                     3.7e-22. Score: 71.0. Matches aSDomain:
                     nrpspksdomains_BM306_RS12445_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006905724.1"
                     /locus_tag="BM306_RS12445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_2503"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_090489612.1"
                     /sec_met_domain="PF00561 (E-value: 9.5e-19, bitscore: 61.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 5.4e-08, bitscore:
                     26.6, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.7e-14, bitscore:
                     45.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYIQLNSQVICYEKTGEGSPVILIHGNKGDHHTFDALAETMSNYH
                     TVYAMDSRGYGESATPKEYHYKDMAEDVINLINALDIEKPYLIGFSDGGIIALLVAIKA
                     SSLLSGIVCCGANLTPDGIHHRDFREMKKEYKKTGDLRTLMMITEPDISTSELSRISVP
                     AMIFAGEKDCIKEKETVKIAKYIPDAQLQILPDENHFSYIVGTDKLYSYIKGFICN"
     aSDomain        19475..19780
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM306_RS12445_Abhydrolase_1.1"
                     /evalue="3.70E-22"
                     /label="BM306_RS12445_Abhydrolase_1.1"
                     /locus_tag="BM306_RS12445"
                     /protein_end="121"
                     /protein_start="19"
                     /score="71.0"
                     /tool="antismash"
                     /translation="PVILIHGNKGDHHTFDALAETMSNYHTVYAMDSRGYGESATPKEY
                     HYKDMAEDVINLINALDIEKPYLIGFSDGGIIALLVAIKASSLLSGIVCCGANLTPD"
     misc_feature    20148..20165
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.6"
                     /tool="antismash"
     misc_feature    21029..21041
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.66"
                     /tool="antismash"
     misc_feature    complement(21186..21201)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 20.61"
                     /tool="antismash"
ORIGIN
        1 catgatgaaa tagaaagccc taaggctgct agatggctag gagagataga aaagctactt
       61 cccaaaaaag aaaaccttaa tatccttgat gtgggatgtg gaacagggta ttttgaagtc
      121 attttaggta gatgcggtca taaggttact ggcatagatt tgactcaaga gatgatagat
      181 agggccaatg agatgattgg actatatggt ttggacaaaa gtgcagttaa ggcaattaca
      241 ggtgatgctg aaaaccttag ttttgaagat gagactttcg atgtggtaat tagccgaaat
      301 cttacctgga cactgccaca tcctattgat gcatacagtc agtggatgcg tgtgcttaaa
      361 aaaggtggcg ttcttattaa ttttgacgca gagtacgcca agggagcaca taatttaaag
      421 agcccagaaa acattgccca cagcaatata gacgatgctt taaaggatga gtgtcaccat
      481 atttatcata tgcttaccat cagtatgcta gatagacctc agtgggatca ggaggttctt
      541 tcacatttag gctttaatga gatagatatt gatagagagt ttggagatag gatttttatt
      601 gagcatgatg aattctatat cccggataaa atgttttgca taaaagctat taaataatca
      661 tgaatactga ttatttatga taactattga ttaaaagtga ttggatcacc acaagtgagt
      721 aaaaaagtgg tggaaagccc taaataatca acaaaaaatc ccatcagacg aatacaaaaa
      781 aatacaattt tttttgtaat tttttcttgc gaaaacgttt aggtcgtggt atattataca
      841 tcgtactagc gaaaagctaa taccaaattt ttcataactc agcgaccagg ggcaactttg
      901 gtcgcactcc ccgaatatta tgccgacaca ttggtgtcgg ctttttatat ttttgtaatt
      961 ttttcttaag ggtatttctc ccagtttttc agcgtttaga cttatatttg ccagaatagt
     1021 tcatctgtgt tataatccta aatgttacga aaatgttact acaatgttac acaatataac
     1081 tttttggaca cggagaacta tgttatgaat aaagcggaag aaccagtttt cgaggccctg
     1141 gagttgtcta atcttgttgg ggattgtatt tcaaaattag atggcgaggc caaggaggct
     1201 aatatttcat tgtctttttc aggagagagg tgtagtgttt ttggcagcaa ggagaacctg
     1261 gaagaggtag tatttaatct tgtggaaaac tctattaaat ataatgacga gggtggacat
     1321 atttgggtaa aggtatacac cagcgatggc cctactattt ccattaagga cgatggcaag
     1381 ggcactcctt acgcggatcc tattatcact agcgttaagg atatagtgga gcttcatcag
     1441 gctaagctga ttaccgataa tggcatcggt gggggctcag aatttaaggt ggtcttttaa
     1501 ctgcaatata gtctataata taagttagaa tcttaagagg gattctaact ttattttttt
     1561 aggagtatta ataatgtctg aagtaaaagt gattgaaata ggagagagcg tattcgcaga
     1621 aaacgaagct gcagctgcat ctattagaga gcagatgaag aagcagggga ctttttttgt
     1681 aaatgtaatg tcaggacctg gttcaggaaa gacaactact ctttctgcaa ttattaatcg
     1741 catgaaggat aaatataaaa ttggcgagat ggacgtggat atagagacta gtattgatgc
     1801 ccagcgtgta gcagatgcca cgggcgttga gtctattcag attcacaaca tgggactttg
     1861 ccatattgat gcagatatga ctagccgtgc tctttctgag tacgatacta ctggtttgga
     1921 tttacttata cttgaaaata ttggtaattt agtgtgtcca gcagagtttg atgtgggagc
     1981 caataaaaat ctcatgcttc tttctgttcc agagggagat gacaagccgc ttaagtaccc
     2041 acttatgttt gaggttagcg atgtggttct gattaacaaa atcgatactt tggattattt
     2101 tgattttagt aaggaaaaag ttactgagag aattttaaag ctaaatccaa atgcgaaaat
     2161 tttcttcgtc agtggtaaga ctggcgaggg cctagatgcc gtggttgatt ggttggaaag
     2221 tgaaattgca gcagtaaagc aagcttagtt tgattggagg ggttatgaag gaaaatcatg
     2281 gtgaacttaa tatgtcagtt tcagcagttt gccagaacga caaggggcaa aagtatgcct
     2341 ttgtgacctt ttctgatggg gttagagatg ctgaaggacg tattccagaa tgtaagattc
     2401 tcaacaataa tggatttgca gcaatcgaag taaacgaatt ggaaaaatac atgcgtgagc
     2461 atctttctga tttaaagaag atggcagcag ggatagatat tttttctgcc ttcacgaaat
     2521 aatttaagct caagagcagt ttgcccttga gcttttttag aatataaaag ggatgttttt
     2581 taggggaaat aattaatagg agaggttcat gagatataaa cagaagagta tgacaagaga
     2641 tgagtatgag tattttttgc aggtcaccgc aggggaagta aaggcggagc ttgtattaaa
     2701 gaatgctaac tttcttgatg tatttaccaa taggtttaaa tcgggagata ttgctatttc
     2761 aagtggtacc tttgcgggga ttggaaagta ctcaggtgca caggagatag acatgacagg
     2821 caagactatt gtgcctggat ttattgatgc ccacattcac atcgaaagca ccacagttgt
     2881 ccctgagata tttgtaaaag agtctattaa gcacgggact actgcagtta taacagaccc
     2941 tcatgagata gcaaatgtaa tgggagtaga tggaatcaac tacatgcttg aggccacaga
     3001 ggggctgcct atggatgttt tctttatgat tccatcatgt gtcccatctt gtaaatacga
     3061 cgaggcaggt gccgttatta tggcatcaga tatggaacag ttctatggca gagatagagt
     3121 caagggcatg gcagagctta tggatgtgga tggagtggta agtaggaatc catcagtttt
     3181 agacaaatcc tattcagcta taaaaaaaga catgctgata gatgggcatg cccctatggt
     3241 aacaggacgg aaattggtaa gttatatagc ggcaggtgtt ctttctgatc atgaatgtgc
     3301 ctccttagaa gaggcgctgg aaaaaatggg acttggtgta tggataatga ttcgtgaggg
     3361 tacagcggca caaaatttag cggatctgat tggcttgtgt caggagcctt atgcatctag
     3421 aagcatgttt tgcacagacg ataggcatat aaatcacatt atggatgagg ggcatataga
     3481 cgctattatt agaaaagcaa ttaagctggg ggcagaccct gctatagctt ataagatggc
     3541 atcctacaat gctgcagcat attttggatt gagagaccga ggggctattt ctccaggatt
     3601 tcttgctgat tttattgtgc ttgaggatat aaatgatgcc agagtaggtg ctgtttataa
     3661 aaatggaata gaaattacag atgaggctct taagctaaaa tgcaagagtc atattacaga
     3721 tgatttgatt gaaaaatcac atgatacttt tcatctgccg tttattacgg aagaaatgct
     3781 tggaaacaag ggcaagcttc ctataatagg tctggtgcct gggcagcttt ataccacaag
     3841 agaggggcta tctgatggga taaatataga ccaggatata ctgaaagttg cagtggtaga
     3901 aagacataat aataccggac atattggcat aggatttgtt aatggatatg gcatgaaaaa
     3961 gggtgctatt gctacatcag tagcccatga tgctcacaat attatagcta taggtgccag
     4021 tgagaaggat atggcacatg ctataaatgc acttaaagat ataggtggag gaatggttgt
     4081 gtgggctgat ggaaaggtga aggcgtcata tccccttccg gtagcagggt tgatgagcga
     4141 agaaagttct gatatgacaa aaaagcattt agaagaaatt catttagcag cctacgaatt
     4201 aggagctaat aaggatattg atccatttat gacattaagc tttacggccc ttccggtgat
     4261 tccggaactt cgcattacca caaaaggcgt ggttgatgtt gcatcaggta agatatttaa
     4321 gtaaaagaaa accagtgcta aaaagcactg gttttatcta tattatctag gtgttatacg
     4381 tgacattaaa tcaacgccag caattgcact tgcctgagca attgtatttg gattatctgc
     4441 actctggtac catgagtatg ccatctttct agatgcatct acattacaga taccgtaagc
     4501 aaggccctga gcaatttcgt ctgtatggtc tgtctctctt gagagaacga taccgtctac
     4561 aaatctatta ttcatagcta caaggtatgc atagacaata gaagctgcct gctgttcctg
     4621 gccatatgca cttgtgtaac ctacctcaga aatcttaaca cttctgactg ctccagatgg
     4681 agaaagtaaa tcaggtgttg ataagtaatc tgtaagtaca tcgaagttgt aaacagttac
     4741 ataaggagca ctctggctat gtggtgcacc tgcgcctaac caagcgcaag gatctgaaag
     4801 ctgtgagttg tatgggtggt gagctaatct ccagtcaatg ttaccctgac tcttgatata
     4861 tgagttaaat gatgaaagga agcccttacc actcatgtaa taaccagcct ctggtctagc
     4921 ccactgatgg tcgatacaag tgtaaacatt tgctgttgaa ttctcagact taataccgtt
     4981 atagattaca cggaatgcat tagcatattc tctaacaaat gcttcgtgag aaccgcagtt
     5041 catgtagttc cacatagtgt aagcattaac ctcattacca atgatgaagt tgtctacctg
     5101 accgtagcca cgaccgcacc aacgattagc aagatatgat gatgcagcag caagaagctc
     5161 tacgccctct tttgttgaag catttaatcc gtagtagttg tggagaccaa gctgatccat
     5221 tgaatatggg ctgatgaatc tgccatcagc agcggcatct accacgataa taactgaaac
     5281 ctgacatccc tgctcattaa acttcttaag tgaaatatca taagctgaaa gtctagctgt
     5341 ctcgaaatta tatgtcttgc cattgtagtt ccaaggaata ccagaaccac cagtaatcca
     5401 agaaagtgga agagtaagat tgacctgtgt acaacctaaa tcctttggct gacatttgcc
     5461 aagctgatat ccttcaagtg ctggaagaat accctttttt gatctatcca tacggcgtgc
     5521 accagcttgt gcagctgcct ctggatttaa aataaacata ctgtttgaaa caggctttaa
     5581 agctccacca gacattacac atacagtgaa tttcttgaag agaactgact cagcagctcc
     5641 cttgttgaga ggtactgaaa atgtagtgcc tgaagcagca ggtgcctgag ccacatctat
     5701 tcctacagga gcgctttcgt ttacgtcgga agcaactaga tggaaaagtc catcatctga
     5761 accggtagca cctgttgtag caataactac atcagagccc tggataagta cacttccgat
     5821 tgcaactgaa ccagcggcct ttgcatcgac tggtggtacc atggcaaaag cagtgattac
     5881 aagcgctagt gaaagtgcta agcttgcaag tgattttaaa accttcataa tgatttgtcc
     5941 tttctgcatt acatttatgt cctttgcgtc aagcaatagg gacattatat cacaaggtta
     6001 taaaaaacac tgcaaaataa ttgtgaaaat aattgtaaca aaatgtgatt atcgctcata
     6061 catgtgtact aactgtaaaa ttttctctgc aagctcatca gaaagctcgt ttttcaaaag
     6121 gcgccactgc cagttgccgc ttttggttcc aggtacatta atacgattga acttgccaag
     6181 tcccagataa tcctgcatct gagctacaaa aagtacggct acagagctca ttccgcccct
     6241 aatcattccc cagttaaact tttcaaagcg agaaatgccg agatattctt tggcatattt
     6301 tctgtcagct tttttggctg tctggtacca ttccataact gtggcattgt cgtgggtgcc
     6361 ggtgtagcag atgcaattct tgtcataggt atgaggctga tagttgttag cctctccaga
     6421 gtcaaatgca aattcaagta ccttcatacc aggccatttg ctgtcattta gaagctttac
     6481 aacagtaggc gatggctggc ctaaatcctc agcaataaac tcggtctttg ggaaggtaga
     6541 agataataga cctactaaat ccatgccagg acctggtttc cactgaccat ttttagcggt
     6601 agactctcca gctggaactg cccagtactc atcaaagcca cggaagtgat cgattctaag
     6661 tacatcatat agctttacag cgccctcaat acggcgaagc caccagcggt agccatcttt
     6721 tttcatagca tcccagttgt agcatggatt gccccaaagc tgtccatcgg cactgaaata
     6781 atctggtgga accccagcta cctcaacagg ataattctta tcatcaagac taaagaattc
     6841 tggctctgcc catacatcac atgagtctag ggctacatat attggaaggt ctccaattat
     6901 ttctatgccc aagtcattga tatatttttt gagcttatcc cactgtttga agaaaagata
     6961 ctgaataaat atgtagaatt ccatatcatc agacaattcc attttatatt ttaaaactgc
     7021 atctttgtca tggagacgta tgtcttcctc tggccattcc tgccagctaa tcatgttgaa
     7081 atgcttttta agcgccatga atagtgcata gttttctacc caagggttgt catctacgaa
     7141 ggcaccgatt tcatttatta ggcttttgta gccccgttcc tttgcttttt caagaacctt
     7201 aaaacggctt atataaatct ggccatagtc cacatatcta gggtttgttc cccatttttc
     7261 ctttttgaca tcttcctttg taaggagacc atcctcaatg agcatatcca aatcaataaa
     7321 ataaggatta ccggcattgg tagaaaagct ctggtatggg ctgtcgccgt agctggtagg
     7381 gcctagagga agcacctgcc aatatttctg tccggcagct ttcaaaaagt ctgcaaattc
     7441 gtatgctgct ttgccaaatg tacctattcc ataaggggat ggcaaagatg aaattggaaa
     7501 tagaattccg ctacttcttt tcatattaat aatctccatt ctaaaaaatt atctaagagt
     7561 ttctccttct cgaagggtag taggtaatgt taaatgctga tgttgccctt cattattaat
     7621 aatgtcaaca agtacatcta cggccttgat gccaatatgt tccattggct gacatagggt
     7681 gctaagaact ggattggtat attcggatgc ctcgatacca tctatagcaa taacagctac
     7741 atcatcaggg acaatctttt tagcatctcg gagcgctttc atggctccca tggccatatt
     7801 gtcagaaatg caaaacagag cagaaaaatc aatgccttta tctaaccatt tactcatttc
     7861 atgatacgcg tcagcaatgt taaaactgtg aatctggatg atgagattat catcctcggg
     7921 gatattaaaa tctttaagcg ctcgcttata tccagcgtat ctaacttggc tgacggagcc
     7981 gtcgtccaca gctgatagaa gaacagctat ctttttgtgt cccttcttat ataactgttc
     8041 aacggcggaa aaagcggtgg cctcatcatc gatacagacg ctggagtact ggtcgctgtt
     8101 tagatttccg tattcattgc taaaggtgca gcagacaaat ggaactccga tggaggatac
     8161 ctgttctttg gtgtaattga gatgtccacc taataagatg agcccctgaa gacgcttatc
     8221 tttttccatc atggcggcca ctctaagttc atcctcatcg gtggatattt gctgcattac
     8281 catggtgtaa cctgatttct ctattttatc cccaatggcg gtgatgattt tagtatagaa
     8341 ggggttggaa atgcctcgca ttattacgcc gatgttgtcg gaagaggaca tgcccaaatt
     8401 tcttgcgcta gtattgggga tataattgta tttgttcaca atagccatga cttttttgac
     8461 agcatcctga ctgacatcag gatgattgtt aagcactctt gaaacagtgc taacactaac
     8521 gcctgcaagc ctggcaatat cttttattgt cataactatt cctttctgat aagttttctg
     8581 gaaacgttac tggaaacgtt tccggaacaa atatataata caaccataaa tgcacccagt
     8641 caatatcatt tattatttgc taagtaaatt actactaaac ttgcaggcac ttttttctta
     8701 tggtaaacta caaaaagcgc tttaggagga taagctatga aaaaaaagct ttttacagta
     8761 ttactttgtg gtgcacttgc agtttcagca gtagcctgca aaaaggaaat aaaatataag
     8821 gcaagcgacc tagtggagct cggccagtac aagggtatgg agattactct taataataat
     8881 tatgaatata cagaagaggg atttgatgca tttgttgaga attcgattca gcagctaggt
     8941 atctttattc cagacgattc acttactact gttgaagaag attctattgt aaatgtagac
     9001 tacgttggat ctaaggatgg agttgctttt gatggcggtt ctgccgagga ccagatgatt
     9061 gatatagcca acaattcatc agcgacccaa aagactggat atattgctgg ctttacagct
     9121 ggacttgtgg gccatgaggt tggagaggag gtagcttacg aggttacttt cccagagcaa
     9181 tataatagcc ctgacttggc tggacagaca gttgtcttca cattccaaat taattatatt
     9241 gccaatgcca tcgattcaaa ggacaagctt acagatgatt tagttgctga gaagattccg
     9301 gactatacta ctgtggatga atatttggca gctcttgaag aaaagtacaa ggacaatctt
     9361 gagactgcat tagaaagtga caaagagaca gctatattaa attcaatttc aaatggcaat
     9421 ataggtacag ttgagaaagt gccagaggac ttgcttcagg ctagagtgga tatgattatc
     9481 aatatgcagg aaaagcagta tgaagcaatg ggcactacca tggaagaata tgccacttca
     9541 gctggatatg attacgagga aactattgct accttgaaaa agaatctaga ggagtctact
     9601 aagacagaga ttattttaga ggctatagct gatgctgaga atatccagat tgatgatggg
     9661 tataaagaat ttgtcaaaaa tatatatact cagatgaaat ataataatgc tgaagaatta
     9721 tattctgatt tctcagtaga gggctatgac ggacgaagat attttgaatt agcctacaga
     9781 accgagaagg ctttagatta tcttgttgaa aactgcgtag tatcatttga ggagccacca
     9841 cttgtagagg atgtggaagt cacagatgat gaggcagttc aagaagatgc aacagaagaa
     9901 tccgctgaat agaaaggctt tatattttac ctaagctgta gtataattta tgctagtttt
     9961 tgggcctatg cccgatttta aaaataaagg agatatgaat atggaacaca ttaagactct
    10021 caacactaag agattacaga atacagtaaa ggaaggcgga tgcggcgagt gccagacatc
    10081 atgccagtca gcttgcaaga catcttgcac agttggaaat cagagctgtg agcacaagaa
    10141 ctaatcacag acttaaattt agttatattt aacgctcaga ccggtcctta ttaattctat
    10201 tattagggaa cggtctattg tgcgtttatg aaaggacatt tttttagtga tacaccagtt
    10261 taaaaacaac ggttacaacg ttgtcataga tgttaacagc ggagctattc acgttgttga
    10321 cgaagtaaca tacgattttc ttgctttctg gcaaaagcaa ggcggggatg cagctttagc
    10381 ttctatgaag gaatcccaca gtgaggtttc tgaggctgag cttttacaga ttaaatcaga
    10441 gattgagagc ctgattgagg acaagtccct attcacagag gataattacg agccacgtat
    10501 tgcagatttt actgcaagac ctacagtagt taaggctctt tgcttacata tcacacatga
    10561 ttgtaatttg gcatgtaaat attgtttcgc agaggaaggc gagtaccaca caggtaagcg
    10621 tgagcttatg acatttgaag ttggtaagca ggcacttgat ttccttgttg ctaattctgg
    10681 cagcagaaga aatcttgagg tagatttctt tggtggtgag ccacttatga actggcaggt
    10741 agtcaaggat cttgtggctt atggtcgttc cattgagaag gagcatgaca aaaacttccg
    10801 tttcacactt actactaacg gagttctttt aaatgacgag attcaggaat ttgctaacaa
    10861 ggagatggcc aatgtagttc ttagctgcga tggtcgtcca gagattcaca atctcatgcg
    10921 tccatttaag aagggcgcac caagctatga gctcataatg cctaagttta aaaagttggc
    10981 agagtctaga aatcaggata aatactacat ccgaggtaca ttcactagaa ataacttaga
    11041 tttttcagag gatgtaattc atctagctaa cgaaggcttt aagcagattt cagtggagcc
    11101 agtagttgct caggagactg atgactacgc tatccgcgaa gaggatttgc caaagctttt
    11161 tgaagaatat gacaagctcg cagcagaaat gatgcgacgc aagggtacag aagaggattt
    11221 caatttcttc cacttcatga ttgatttgga gggtggtcct tgtgtataca agagactttc
    11281 aggttgcggc tcaggtacag agtacatggc agttacacct acaggagagc tttatccatg
    11341 tcaccagttt gttggtaaca cagacttctg tttaggtgat gtatggcacg gcgttcagaa
    11401 gaaggacgtt gtcaatgagt tcaagcactg caacgtatat gctaagccag agtgtagaga
    11461 gtgctttgca agattctatt gtagcggtgg atgtgctgct aatgcattca acttcacagg
    11521 cagcattctt ggcaattacc atgtaggttg cgagcttcag aagaagcgtg ttgaatgtgc
    11581 tatcgcactg aaagttaagg aagcagaaat aaagggagaa taaccctttg gtcagctttg
    11641 ctgacaaata aaaggaaata ggagaataaa catgaaacga ttaaaaaaag gacaggggat
    11701 tgcctggctt atagcatttg ttttatgtct cggattactg ggatattatg caatgactgt
    11761 agttcaggga actattaagg ctaacgacac aagtcttaag ttgggagcag atgccacaga
    11821 tgcacagaag gctaagatgg ctaagtataa tgctgacagc ttaaagttgg ggcttgattt
    11881 agatggtggc gttagtatta catatgaggc aattggtgac aaacctactg atgagcagat
    11941 gaatgataca attcttaagc tccagcagcg tattgagaat gaccttggtg aggagagctc
    12001 tactacagag gctaatgttt accgtgtagg agacaagaga atcactgttg agattccagg
    12061 tgttacagat gctaatgctc ttcttaagga gcttggtaca ccaggtactc tttacttcat
    12121 tatgcagtat gatgaccagg gtaatgccaa ttacactaca acaggtagag acgagaatgg
    12181 tgacattcag ggtacattaa actatgatat ccagacactt attgataatg gctcagtaat
    12241 tgctacaggt aagaatgtta gaagttctca ggctggtact gaccaggaca agacaacagg
    12301 tgctactgag tatgttgttg agcttaagtt tgatgatgca ggtacaaagg catttgctga
    12361 tgcaacttca aaggcgtatg ctaacggctg gtcaattgca atttactacg atggtaaatt
    12421 cgtatcagtt cctacagttc aggcagctat cacagatggt aactgcgtaa tcaacggaat
    12481 gagtgattat gcagaggctg agaagcttgc ttcatatatt cgtatcggtg gacttgatat
    12541 tgagcttcag gagttagagt cacaggttgt tggtgctcag cttggttcag atgcgcttaa
    12601 gacatcgctt attgcaggtg gtattggtct tcttgttgta atgcttttct taatcgttat
    12661 gtatttagta ccaggtgtag ttgcttcact tgcacttgca ctttatacag taatgcttgt
    12721 aagcatctta aaggcatttg atattacact tacacttcca ggtatcgctg gtatgattct
    12781 ttcaattggt atggctgttg acgccaatgt tatttgtttc gctcgtgttc gcgaggaaat
    12841 caaagcaggc cgtcctgtaa tctcagctat tgagacaggt ttctctaagg ctctttcagc
    12901 tatacttgat ggaaacatca caacacttat tgcagcagca gtgcttggct tccttggatc
    12961 aggttctgta aagggatttg ctatcactct tgcacttggt gttatcttat caatgtttac
    13021 agcacttgtt attacaagaa tccttattaa tgctttctat gctatcggca tcagaaatgc
    13081 taaggcatac ggcaaggcta aggagcctac aaagttcgac ttcgttggca aaaaggcaat
    13141 tttcattggt atctcagtat ttataattgc agcaggcttt atctcaatgg gcgtattcaa
    13201 ggctaagaac ggcagcggac ttaactactc ccttgagttc atgggtggtg cttctacaac
    13261 agtagatttt gcagcaccac agactgatga tgtaatcaac aatcagatta ttcctgatat
    13321 tcagaaggta atcggtgacg gaacagttca gaagagtaca gttgatggta caaatcaggt
    13381 aatcttcaag actcgtacac tttcacttga tgagagaaca gcacttaata caatgcttga
    13441 gactaactac ggcgttacag aagaatcaat cacttctcag aatattggtt ctacaatttc
    13501 aggcgagatg cgttctcagt caatgattgc agtaattgtt gctgtattct ttatgcttct
    13561 ttatatctgg ttcagattta aggatcttag atttgcatca tctgcaatca ttgcacttgt
    13621 acatgacgta cttattgtac tttcacttta tgcatttgct cgtatttcag taggtgctgc
    13681 atttatcgca tgtatgctta cagtaattgg ttactctgtc aacgatacaa tcgttgtatt
    13741 tgatagaatt cgtgaaaacc acaaggcaat cagaacagag actccagaga cacttaagga
    13801 gttatgtaat gagtcattgt cacagacact ttcacgttca atttctacat ctattacaac
    13861 agcaatcatg gtacttatgc ttctcatcct tggtgtttca tcaatcagag agttcgcatt
    13921 accacttctt gctggtgtaa ttgcaggtac atattcttca atcttcattg ctacacagct
    13981 ttggtacatc tttaaatgta agattggaaa aaagaactaa ggttatagaa ctaggagaaa
    14041 taagatgata gacattaagt ttttgcgtga gaatccagac gcagtaaagg aaaacatcaa
    14101 aaagaaattt caggaacaca agcttggcct cgtagatgag gtcatcgagc ttgatgataa
    14161 gagacgtgct gctcagcagg aagctgatga catgagagct aagatgaatc aggctgcaaa
    14221 gcagattggt gctcttatgg gacagggcaa gaaggacgag gctgaggctg ttaaggctga
    14281 ggtggctgac ctcaagcaga agattaagga cttagagcca gttgagaagg agcttgcaga
    14341 caaggttgag gaaatcatga tgaagattcc taacattatc gatccttcag ttccaatcgg
    14401 tccagacgat tcttgcaatg ttgaaatcga aaagtttggt gagccagtag ttcctgattt
    14461 tgagattcct taccatacag atatcatgga gagattcaat ggtattgata tggatgcagc
    14521 tggaaaggta gcaggtaatg gtttctatta cctcatggga gatattgctc gtcttcactc
    14581 agcagttatc tcttatgcac gtgatttcat gattgataga ggatttacat actgtattcc
    14641 acctttcatg attcgttcaa acgtagtaac tggtgttatg tcatttgaag agatggatgc
    14701 tatgatgtac aaaatcgagg gcgaggacct ttaccttatc ggtacatcag agcactctat
    14761 gattggtaag ttcatcgata cacttaacga tgaggctaac ttaccttata cacttacaag
    14821 ctacagccca tgcttccgta aggaaaaggg cgctcacggt atcgaagagc gtggtgttta
    14881 tcgtattcac cagttcgaga agcaggagat gatcgtagta tgtaagccag aagagtctaa
    14941 gaaatactat gatgttctct ggaagaacac agttgattta tttagaagtc ttgatattcc
    15001 tgttcgtact cttgagtgct gctcgggaga tcttgcagat ctcaaggtta agtcatgtga
    15061 cgtagaggca tggtcaccac gtcagaagaa gtacttcgag gttggtagct gttcaaatct
    15121 tggagatgca caggctcgtc gtcttaagat tcgtgttaag ggtgcagatg gaagcaaata
    15181 cttcgcacac acacttaaca acacagttgt tgctccacca cgtatgctta ttgcattcct
    15241 tgagaacaac ttacgtgagg atggctccgt agctatccct gaggcacttc gcccatacat
    15301 gggtggcaaa gaggtactcg tgcctatcaa ataaatttta aagcggcatc ctagttttac
    15361 atgctcccgc aagtcaactc ccattggtcg caacagaaac tccccgccgg cgtgggtccc
    15421 ctctgttgcg cccatggggc cctcttgctc gcgcttgcca agacagtgat gccgctgtat
    15481 tatatatgag ctggtagaca acaagctctt tgatttctca agcgaaacct gttgttgagc
    15541 ggagaaatac aaaggcttgt aggcgtaacc agcggttttg gggtttttac tgtaactaaa
    15601 gttttgcagt agaaagagat tattatggca gttcagagta gagaagatat tagaaatatt
    15661 gcgattatcg cccatgtaga tcatggtaaa accacacttg ttgatgagct tttaaagcag
    15721 tcgggtgtat tcagagagaa tcaggaagtt gcagagcgtg tcatggactc aaatgatatt
    15781 gagcgtgagc gtggtattac aattctttca aagaatacag ctgtatatta taaggatact
    15841 aagattaata ttattgatac accaggtcat gctgatttcg gtggcgaggt agagcgtgtt
    15901 cttaagatgg ttaacggtgt tgttcttgta gtagatgcat tcgaaggtgc aatgccacag
    15961 acaaaattcg ttcttatgaa ggctcttgac cttgatttac cagttattgt atgtattaac
    16021 aaaattgata gaccagaggc tagacctgat gaggttatcg atgaagtatt agagcttttc
    16081 atggatcttg atgcttctga tgagcagctt gattgcccat ttatttatgc cagcgctaag
    16141 gaaggctttg ccattaagaa cttaagcgat gagcacaagg acatgacagc tttatttgag
    16201 actatcatcg attacattcc agctccaact ggtgatccag aggctcctac acaggtgctt
    16261 atctctacaa tcgactacaa cgagtacgta ggtcgtattg gtatcggtaa ggtagagaat
    16321 ggttctatca aggtgaacca ggatgcggta gttgtcaatg ctcatgaccc agagaagaat
    16381 aataaggtcc gcatttcaaa gctttttgaa tatgatggac ttgaaaaagt agatgttaac
    16441 gaggctaata ttggttcaat cgttgctatt tcaggtattg ctgatattca tatcggtgat
    16501 acaatttgcg cagtagatgc tccaaatcct atcccattcc agaagatttc tgagcctacc
    16561 atttcaatga atttcattgt aaatgatagc ccacttgctg gtcaggaagg taagtacgtt
    16621 acttcacgtc acattagaga gcgtcttatg aaagagttaa atacagacgt ttcacttaga
    16681 gtagaggata cagattctcc tgattctctc aaggtttcag gacgtggtga gcttcacctt
    16741 tcagttctta ttgagaacat gcgtcgtgaa ggatttgagt ttgctgtatc aaaggctgag
    16801 gttctttaca agacagatga gaagggccac aagcttgagc caatggagcg tgcttatgta
    16861 gatgttccag atgaatttac aggagcagtt atcgaaaagc tttctcagag aaagggcgag
    16921 cttcagaata tgacaccaat tactggtggc tttacacgaa ttgagttcaa gattccttca
    16981 cgtggtctta ttggatatcg tggagaattc atgacagata caaaaggaaa tggtataatc
    17041 aatacaattt tcgacggata tgagatttat aagggcgaca ttgcttatcg taaacaggga
    17101 tctcttattg catttgagac tggtgaatca gtaacttacg gacttttctc agctcaggag
    17161 cgtggtacac ttttcattgg accaggcgag aaggtttact caggaatggt tattggtcag
    17221 agctcacgtg cagaagatat cgagcttaat gtatgcaaga agaagcacct tacaaataca
    17281 cgttcatctt cagcagatga ggcgcttaca cttgttccac ctagaattct tagcttggag
    17341 caggctcttg actttatcga tgtagatgag cttttggagg taacaccgga gtcactcaga
    17401 atcagaaaga gaatccttga tcctcttatg agaaagagag caggtattcg caagtagtaa
    17461 ttcaggggga attgcatgga aaatgtattg gggattgatg gcggcacata cattggattt
    17521 ctcacatgtg tgggcatgct actgtttatt atcgctatgc gatcatttga cccaaagtta
    17581 aggacacaat ttattaagtt ggtcgttgcg gtaatgattt ctcttgcagc cgctgctgta
    17641 gatatgtatc ttgatacatt ggctgagcca ctagctatac gctatttggt taaaaatgta
    17701 aagtacatta ctcaggggct gtcggagtat tttgtgcttc taataatcat tagagatcac
    17761 acaaatctta ataaaaaatt gctgttaata ccatttgtta tcgctagtgt agtggtatgc
    17821 ttagctccgt ttagcagtag gatttattcc tttactgctg acaatcaatt tataagagga
    17881 ccaattggaa atattatttt catacaggct gcttcttata ttgtggtcac acttttagcg
    17941 tgcatacata aatggtttga tggatatcaa aatgatgcca cagtgattct atttatgctt
    18001 tttgcagtgt gtgtgggagt catcctagaa gaagaaaaaa tattcccaaa ttgcacaatg
    18061 gaatcaagca ttgtcggcgt tgtattccta tatatttata tatatgcaga gagatacaat
    18121 gtagattctg tatctagatg ctacaagaga agatgctttt attctgatgc caatagatat
    18181 tccaagctgg acatgatgat tatctctatg gatcttaatg atctgaagct tatcaatgat
    18241 aattatggtc acaaggcggg agatattgcg ctacttactt ttgcagaagt agttcgaagt
    18301 gtaaagacta acaaattcat cctttaccgt acaggaggag atgagtttat gattcttggc
    18361 attaaggcta cggaggatga ggcaaaggag cttgttgagc ttgtaaaaga aaagcttact
    18421 gagacacctt atacttgttc atttggaatc tatccttata agccgggaga tgattttgat
    18481 gcagcagttg tgagagcaga caaggcgatg tatgaggata aaagtgctta taaagctagc
    18541 aagagcaagc gaagtcattc tagaagtgat gagtttgaaa gcaggcttga gacatttact
    18601 aacaatatta gctttttagg ttgaggtgaa caatgacaag agtagttatg cacggctgta
    18661 atggccatat gggacgagtt attactgaca tttgtgctgc tgatgcagat gttgagatag
    18721 ttgcaggtgt agataagttc aagggaatcg ataacagcta tcctgtttac gactctattg
    18781 ctgaggttaa ggaaaacttt gatgctatca ttgatttttc aaatgtagca gcaatcgatg
    18841 gattacttga ttactgtgta gctaataaca agcctgttat tctttgcaca actggattga
    18901 ctgacgatat gctcaagcac gttgatgaag cttgtaaatc agttccagta cttcgttccg
    18961 ctaacatgtc tcttggtatt aatacattat ttgatttatg caaaaaggca actaaggtat
    19021 ttgctgatgc aggatttgat atcgaaatag ttgagaagca tcataatcaa aagcttgatg
    19081 ctccaagtgg aacagctctt gcacttgcag atgcttgtaa tgaggctctc ggaaatgaat
    19141 atgagtattg ctatggtaga gctgatagac gtgagaagag accagttaag gaaattggta
    19201 tctcagcagt tcgcggcggt aatatcgtag gcgagcacga agttattttt gcaggtcttg
    19261 atgaggttat tacaatcaag cacacagctt attcaaagag cgtatttgct aagggcgctg
    19321 ttgaagctgc taagtatatt gtaggacagc cagcaggact ttatgacatg aagaaggtta
    19381 tcagcaacaa ataataactg ataaataagg ggacaatatg tatattcagc ttaactcaca
    19441 agtaatatgc tatgaaaaga ccggcgaggg ttcgccggtt attcttatac atggaaataa
    19501 gggcgaccat catacttttg atgcattggc agagacgatg agcaattatc atacagtata
    19561 tgcaatggat tcaagaggtt atggagaaag cgctactcca aaggaatacc actataagga
    19621 tatggcggag gatgtaatca atcttatcaa tgctctcgat attgaaaagc catatcttat
    19681 tggattttct gatggaggaa ttattgcttt attagtagct ataaaggcaa gctctttact
    19741 ttcaggaata gtttgctgcg gagctaatct tacaccagat ggaatccacc atagggattt
    19801 cagggaaatg aaaaaagaat acaaaaagac aggtgatcta cggactctta tgatgattac
    19861 tgagcctgat atttccacgt cagaactgag taggatatca gttcctgcta tgatatttgc
    19921 aggagagaag gattgcatca aagaaaaaga gacggtaaaa attgcaaaat atataccaga
    19981 tgcacaactt cagattttgc cagatgagaa tcactttagc tatattgtag gaactgacaa
    20041 attgtatagt tatataaagg gattcatttg caattagtgt taaaaagtta acgaaaagtg
    20101 gctgattcta ttgctatatt ccatgaacca tgttaatatc tatataaatg ttataaaact
    20161 gtgaatgcat taaatataac attttagata taacgattta ttggcgattt ggagtacatt
    20221 tatggcaaag ggtgctaaga agacctgtta ttgtgataaa ctgaataaag cattaatagg
    20281 tatttgctta gcagctgtta tagtttgcta tctttttact atttcacgat atacaacaga
    20341 tgcatttaca aaagatattg agccatatgc tgttgttaaa ttagatgatg gttctacgga
    20401 gtatctattt gatctcagaa agctagatta taaatattct ggctttatgt tctatacatc
    20461 ccacaaaaag gtagaagttt ataatggcgg taatatgatt tattcattta ccaagacagg
    20521 cggtatttgg tcttcatcta caggctctgc ttatcatttt gttgatatta atgagcgtat
    20581 gactaatatc gctgttattg tcacacctat ttatgacgtg gtggcagatg atgaaatcct
    20641 atttcaagta gggtcttcat acaatatgta caatgacatc atggttaagt ccatgcctcg
    20701 atttgttgca agtatgctta ttcttgtaat aagcatttca ttgattgttt attatcattt
    20761 tatgaaaaag aagctggaaa tcggcgagga acttatatat cttggatact ttgctttgtt
    20821 cattggactt tggacattca tggagacaga tgtaatcact ttgattttca aaaacaagat
    20881 tgttgaagtg gtggttcctt acttatgtct tatgtttgtt atcccgcctt ttgtgctgtt
    20941 tttccattgc tatctgaagt ttaaaaatga atggattaag aacataataa ttactatgtc
    21001 tagcctggaa ttaatagtgc tttcgttctt gcattttaca aagatagcag aatatagaga
    21061 gactttacca tatgttcacc taatgatatt tattgctacc atttacgtgg ttgtgggtgt
    21121 tgtaattaag atgattaata aaaactacac aagacgcgtg gaggtatgtg tggttggtct
    21181 gacactattt gcttttggcg ttatatttga tattgtttct tattacaagc gaattggtga
    21241 ttcagatcag cttggcagat atttattcct tgtgttcctt gtactcttgg cttgggattt
    21301 gttaaagggt acatacgagt tcattgaaaa ggggcgccga gcaaagcagc ttgagttatt
    21361 tgcacttaca gacagcatga caggtctttt aaatagaaat gcatttgaaa cttatgctaa
    21421 ttctaatggt gagttggaag atttggtagc tattgttgca gatgctaatg gattgaagga
    21481 atgcaacgat acgcatggtc atgatgttgg tgatgagtat attacagttg ttgctgatat
    21541 attcagcagt acatttggaa aatatggtga ttgctatcgt acaggtggag atgaattctg
    21601 ctgtatcatc ccatcaggca agg
//
