LOCUS       NZ_FOZB01000001        23716 bp    DNA     linear   CON 28-FEB-2024
DEFINITION  Pseudobutyrivibrio sp. NOR37, whole genome shotgun sequence.
ACCESSION   NZ_FOZB01000001
VERSION     NZ_FOZB01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Pseudobutyrivibrio sp. NOR37
  ORGANISM  Pseudobutyrivibrio sp. NOR37
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Pseudobutyrivibrio.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/28/2024 14:17:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,726
            CDSs (total)                      :: 2,671
            Genes (coding)                    :: 2,662
            CDSs (with protein)               :: 2,662
            Genes (RNA)                       :: 55
            rRNAs                             :: 1, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1 (5S)
            partial rRNAs                     :: 4, 3 (16S, 23S)
            tRNAs                             :: 43
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 9
            CDSs (without protein)            :: 9
            Pseudo Genes (ambiguous residues) :: 0 of 9
            Pseudo Genes (frameshifted)       :: 3 of 9
            Pseudo Genes (incomplete)         :: 8 of 9
            Pseudo Genes (internal stop)      :: 0 of 9
            Pseudo Genes (multiple problems)  :: 2 of 9
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:29:30
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 114096
            Orig. end                         :: 137812
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOZB01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23716
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="deazapurine"
                     /region_number="1"
                     /rules="(GTP_cyclohydroI and PTPS and QueE and QueC and not
                     (dpdA1 or bTGT))"
                     /tool="antismash"
     cand_cluster    1..23716
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /kind="single"
                     /product="deazapurine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23716
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:13716]"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13716
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(GTP_cyclohydroI and PTPS and QueE and
                     QueC and not (dpdA1 or bTGT))"
                     /neighbourhood="10000"
                     /product="deazapurine"
                     /protocluster_number="1"
     misc_feature    542..556
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 16.95"
                     /tool="antismash"
     gene            complement(841..2298)
                     /gene="moeB"
                     /locus_tag="BM306_RS00610"
                     /old_locus_tag="SAMN04487829_0121"
     CDS             complement(841..2298)
                     /GO_function="GO:0008641 - ubiquitin-like modifier
                     activating enzyme activity [Evidence IEA]"
                     /codon_start=1
                     /gene="moeB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163: rhodanese domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF004281.0"
                     /locus_tag="BM306_RS00610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0121"
                     /product="molybdopterin-synthase adenylyltransferase MoeB"
                     /protein_id="WP_090485479.1"
                     /sec_met_domain="ThiF (E-value: 1.1e-57, bitscore: 191.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVYISATLRGFFGKNHKFDIPAENIRGILDWLTDEYPDSKEILF
                     DEDKHLRSFIQIYVGDINKSDESTWSDALIPGRDVYLLPAIAGGSPKNSIISDERAKAV
                     SFDDSEVERFGKHLMLRDIGVKGQKRIKAAKVVVIGAGALGSPVIQYLAAAGVGTIKVV
                     DFDVVALDNLQNQVLHSSRDLKRPKVASARDKVKNINKNIVFEPENVKLDADNIVEIID
                     GYDLVIDCTDNYKARYLINDACALIGIPLVFGAIYQYEGQVGIFNLNGGPCYRCVFPAP
                     PPAGLVPTCSEGGAISPLPGIVGSIQANEALKLIIGIGENLSGKLLTVDSLYLRSNLLT
                     VTKSHKCPICGDNPSIIKVENFDYDDFCGLKEAEEEIPVEGFTAEEFASKIENDEALTI
                     VDVREPHERAILRFPNAVVIPIGQLARRKGELNPEIPTVFLCKEGKRSILAINTLREAG
                     YDGPMYNLKGGIDSLKDIMFSHEGAWL"
     gene            complement(2310..2717)
                     /locus_tag="BM306_RS00615"
                     /old_locus_tag="SAMN04487829_0122"
     CDS             complement(2310..2717)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025819.4"
                     /locus_tag="BM306_RS00615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0122"
                     /product="M67 family metallopeptidase"
                     /protein_id="WP_090485482.1"
                     /transl_table=11
                     /translation="MLQINKEAFFKLTSISEAQYPNEACGVLLGNSDLNQVNDVCNLPN
                     LVAETDSFRIDSLDYLMIEKWAQHHHLDVIGFFHSHPDAAAILSEEDKTYMIPKLNYCI
                     TSVASDGTKQVKAYFRQNIWEGIEELEINVK"
     gene            2970..3764
                     /gene="proC"
                     /locus_tag="BM306_RS00620"
                     /old_locus_tag="SAMN04487829_0123"
     CDS             2970..3764
                     /EC_number="1.5.1.2"
                     /GO_function="GO:0004735 - pyrroline-5-carboxylate
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006561 - proline biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="proC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005424275.1"
                     /locus_tag="BM306_RS00620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0123"
                     /product="pyrroline-5-carboxylate reductase"
                     /protein_id="WP_090152075.1"
                     /transl_table=11
                     /translation="MKIGFIGTGNMGSAMMGGMVSSGIVAASNVMASDIFQAALDRISD
                     QLNIATSTNNRDVVDFADIVFLAVKPQYLAGAIDGIKDMDFTDKIVVSIAAGQSIEKLT
                     ELFGKQLKLIRVMPNTPALVGEAMSALSPNELVSEDEADIVLHLFESFGKAEIVPEKLQ
                     DAVVGISGSSPAYVYMFIEALADGAVAEGMPRAQAYKFAAQAVLGSAKMVLETGEHPGV
                     LKDAVCSPGGTTIEAVATLEALGFRNAVIEAERVCVEKSRDL"
     misc_feature    2971..2985
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.67"
                     /tool="antismash"
     gene            4326..5246
                     /locus_tag="BM306_RS00625"
                     /old_locus_tag="SAMN04487829_0124"
     CDS             4326..5246
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="BM306_RS00625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0124"
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="WP_090485485.1"
                     /sec_met_domain="Abi (E-value: 5.8e-15, bitscore: 51.6,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTTVTKCNSGKVKKTIWQKILDFPLVPLIEIAIIGIIGNFLGRG
                     VSNLFRPFANEQNIDSIRFLAAYFSTAGTVIAQLIYMWVVKPHRPMLKTMGTSISGNNI
                     KMAFIGLVVGLVMNGSAILVAALHKDVKLHFAGGSLLLFILLFIAVLFQASNEEILCRC
                     FLYHRFNKIFKRPAVAMFIASTLFGFLHLLNPGVSPLAIINVVLAGLWLGLLMYCFDSI
                     WMAIAAHLGWNYSQSIIFGLPNSGNASAFSLLKYDMASATNSFAYNVDFGVEGTVFVCI
                     MLLVIDCGLIVYAITKKKQPTDVYL"
     gene            5309..6073
                     /locus_tag="BM306_RS00630"
                     /old_locus_tag="SAMN04487829_0125"
     CDS             5309..6073
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="BM306_RS00630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0125"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_163927100.1"
                     /sec_met_domain="Abi (E-value: 3e-17, bitscore: 58.9,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKKKCVIGIILAMIFSFGISMVAYNLFPENTIAQVILEAIDVAG
                     LLGIIIAFGQKRELGFSVGSFIEGIKLNAYVLAYAVPFFIYHLVDWLLGNGGPDFYANT
                     IGSALILFLTAGMREELLFRGIAFNFIKATGELSRPMVIKASVISALLFGILHFSNYFF
                     GQDLLSTLCQVVYASAIGIFFAAVYFRTKNIWANIAVHFFFDFAHVNMEEVLGVKGNLV
                     GESMSTLIYSIVTIAVAFYLMREKKLQPVLQG"
     gene            6114..6713
                     /locus_tag="BM306_RS00635"
                     /old_locus_tag="SAMN04487829_0126"
     CDS             6114..6713
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013718.4"
                     /locus_tag="BM306_RS00635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0126"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_090485489.1"
                     /transl_table=11
                     /translation="MVNGDIFYFSWELDFLHWLQGIHNPILDKIMITATNLEDYVLILL
                     LIFIGLTVFPRSRKIGGTLLVATIVCFLIVNVGMKPFITRCRPCWLEPSVKLLVNAPHS
                     FSFPSGHTNAFFAMATAVFLRNKKIGIPCLATASLIAFSRLYLFVHWPTDVLGGIVTGI
                     VSAIIGYMAIEALSKLFGRIKKRIKEKKYENKFEIN"
     gene            6688..7503
                     /locus_tag="BM306_RS00640"
                     /old_locus_tag="SAMN04487829_0127"
     CDS             6688..7503
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="BM306_RS00640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0127"
                     /product="type II CAAX endopeptidase family protein"
                     /protein_id="WP_090485492.1"
                     /sec_met_domain="Abi (E-value: 3.1e-18, bitscore: 62.1,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTSLRLIKYLGAIVLSFILMTFIPSLVLSYINITNYYVMVSVYL
                     LVIIGILAVTVIVFGEKKVFAFSLKSFKDTFVIGGVMTAITAFYLVTNIYTAIKEYGTP
                     LMDGKTIVLFLLLNFLGAGIREELLTRGVWLTFFRKAFGNSKASYIVAMSLSSILFGAI
                     HITNLDGAVDPTPIYAQIIYAIGIGFFLAALYFRTGNLWGNMVLHFLFDISLMVKPMIY
                     GNRSDMDVLIGEWLGSGIILKSILISVVSVVIGLYLIRGDKFKEIAEAE"
     gene            7506..8471
                     /locus_tag="BM306_RS00645"
                     /old_locus_tag="SAMN04487829_0128"
     CDS             7506..8471
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (68-194). E-value: 3e-14.
                     Score: 45.2. Matches aSDomain:
                     nrpspksdomains_BM306_RS00645_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.4"
                     /locus_tag="BM306_RS00645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0128"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_090485495.1"
                     /sec_met_domain="PF00561 (E-value: 5e-12, bitscore: 42.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 1.2e-07, bitscore:
                     28.3, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFLKYTRRFFIVSLCLIIVLLVTTSIVYRVKLHKIMNTLEPCR
                     CLVSAGEYELNVARIGNRDGKHKIVCCSGLNDGTMNISWRNMTKYIEKDNELLFIDRAG
                     YGLSEDTKEDRTVDQIVEDYRTVLKNLGEEGPYILMGHSIGGMYTSYWQSKYPEEVEGL
                     IIMDGTLCNLVDEEEKTAAVKQWRFLSIAEKVGLEPLVMKKLYYKNLLDNVSDREADFH
                     LYLFSKTTGSHATISEVNLVYDNAQAVWNSLKPNDVPKIFIDASYQVANNSDFEKDYWI
                     PYAEKMGNCDIVPLYGSHSIYFEKSKECGNIVKNFIAELD"
     aSDomain        7710..8087
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM306_RS00645_Abhydrolase_1.1"
                     /evalue="3.00E-14"
                     /label="BM306_RS00645_Abhydrolase_1.1"
                     /locus_tag="BM306_RS00645"
                     /protein_end="194"
                     /protein_start="68"
                     /score="45.2"
                     /tool="antismash"
                     /translation="IVCCSGLNDGTMNISWRNMTKYIEKDNELLFIDRAGYGLSEDTKE
                     DRTVDQIVEDYRTVLKNLGEEGPYILMGHSIGGMYTSYWQSKYPEEVEGLIIMDGTLCN
                     LVDEEEKTAAVKQWRFLSIAEK"
     CDS_motif       7905..7946
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BM306_RS00645_0001"
                     /evalue="1.60E-05"
                     /label="NRPS-te1"
                     /locus_tag="BM306_RS00645"
                     /protein_end="147"
                     /protein_start="133"
                     /score="17.5"
                     /tool="antismash"
                     /translation="EGPYILMGHSIGGM"
     gene            8553..9668
                     /locus_tag="BM306_RS00650"
                     /old_locus_tag="SAMN04487829_0129"
     CDS             8553..9668
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006857136.1"
                     /locus_tag="BM306_RS00650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0129"
                     /product="SLC13 family permease"
                     /protein_id="WP_090485497.1"
                     /transl_table=11
                     /translation="MDAVKRFIRNEIVLCVAFVLAVISAFVIHPDKSYFAYIDYRTLSI
                     LLALMITMAGLQRLHVFRQIGELLVAKMSSIRGVTLILIALCFFSAMFITNDVALLTFV
                     PFSIVTLSISGRKDLYIIVIVLETIAANLGSMLTPLGNPQNLYLYSIAGMSLGAFIKLM
                     LPYSVVALAMLVIATVIRVKSAPVVLTEKSVYERKARDKKLIAMYVFTFLVSILVVARV
                     LDYRIGLLIVALLAFIFDRRVLRKPDYSLLFTFIFLFIFIGNIKRIPELSGALSQLVKV
                     NEVGVSIGLSQVISNVPAAILCSGFTDQIDKLIIGTNLGGLGTLIASMASLISFKQYSY
                     IDGSDSKKYMIVFTAFNIIFLAVMCALYLLM"
     gene            10001..10423
                     /locus_tag="BM306_RS00655"
                     /old_locus_tag="SAMN04487829_0130"
     CDS             10001..10423
                     /EC_number="4.1.2.50"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070497 -
                     6-carboxy-5,6,7,8-tetrahydropterin synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: PTPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015550083.1"
                     /locus_tag="BM306_RS00655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0130"
                     /product="6-carboxytetrahydropterin synthase"
                     /protein_id="WP_090485500.1"
                     /sec_met_domain="PTPS (E-value: 2.9e-34, bitscore: 113.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYLTAEASFDGAHFLAGYEGKCSNLHGHRWRVILNIKSEKLQAE
                     GQQRGMVVDFGDVKSALKKETDYFDHTFIYEEGSLKDTTVAALKDENFLMRVVPFRPTA
                     ENFSKYFYEKFTSYGFKVAEVTVYETPNNCASYRED"
     gene            10426..11094
                     /gene="queE"
                     /locus_tag="BM306_RS00660"
                     /old_locus_tag="SAMN04487829_0131"
     CDS             10426..11094
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="queE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015550082.1"
                     /locus_tag="BM306_RS00660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0131"
                     /product="putative 7-carboxy-7-deazaguanine synthase QueE"
                     /protein_id="WP_090485504.1"
                     /sec_met_domain="QueE (E-value: 1.1e-38, bitscore: 129.2,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.9e-13, bitscore: 46.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 6.4e-15, bitscore: 52.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVFNVVEKFVSINGEGQHAGELAVFIRLRGCNLSCSYCDTRWAC
                     TDEADAEAMSEDEIISYVKSTGVRRVTLTGGEPLLAEDIGVLLEAFSSEKNFLVEIETN
                     GSVFVGDFAKIDNPPAFTLDYKLAGSGMEDKMDLSNFKYLQKKDTVKFVCSNVSELDKV
                     CEIVDEFSLSEKCTVLISPVFGRIEPADMVDYLIKHKRNDIRLQLQLHKFIWDPNKRGV
                     "
     gene            11106..11678
                     /gene="folE"
                     /locus_tag="BM306_RS00665"
                     /old_locus_tag="SAMN04487829_0132"
     CDS             11106..11678
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: GTP_cyclohydroI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015550081.1"
                     /locus_tag="BM306_RS00665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0132"
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="WP_090485507.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 6e-66, bitscore:
                     217.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAINKELIKESIRNIIIALGDDPDRAGLLETPDRVARMYEEVFEG
                     MNYSNAEIADMFNKTFDEDYYDEDSQDLVFVKDIEVFSYCEHHLALMYDMKVSVAYIPN
                     GKVIGLSKIARIADMAAKRLQLQERIGNDIAEILQMVTGSEDVAVFIEASHSCMTARGI
                     KNAGARTHTQTLRGRFKTDSDLLARLH"
     gene            11708..12394
                     /gene="queC"
                     /locus_tag="BM306_RS00670"
                     /old_locus_tag="SAMN04487829_0133"
     CDS             11708..12394
                     /EC_number="6.3.4.20"
                     /GO_process="GO:0008616 - queuosine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015550080.1"
                     /locus_tag="BM306_RS00670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0133"
                     /product="7-cyano-7-deazaguanine synthase QueC"
                     /protein_id="WP_090485510.1"
                     /sec_met_domain="QueC (E-value: 8.3e-63, bitscore: 207.8,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 8e-06, bitscore:
                     21.8, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVLVSGGVDSTTCLGMAVKEYGHENVVGLSIFYGQRHDKEIK
                     AADAVCDFYKVEHITLDLSTMFQFSDCTLLQHSDGEIPEESYAEQLSKTDGKPVSTYVP
                     FRNGLFLSSASAIALSKGCSKIYYGAHSDDAAGNAYPDCSEAFNKAMNTAIYEGSGKQL
                     EIVAPFISLNKSQVVKKGLEIGVPYELTWSCYEGHEKACGKCGTCIDRKAAFELNGVKD
                     PIEYEN"
     gene            12422..12913
                     /gene="queF"
                     /locus_tag="BM306_RS00675"
                     /old_locus_tag="SAMN04487829_0134"
     CDS             12422..12913
                     /EC_number="1.7.1.13"
                     /GO_function="GO:0033739 - preQ1 synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="queF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015550079.1"
                     /locus_tag="BM306_RS00675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0134"
                     /product="preQ(1) synthase"
                     /protein_id="WP_090485513.1"
                     /transl_table=11
                     /translation="MADRAAEGTLTLLGNKNNVYPDNYAPEMLQTFLNKHPENDYFVKF
                     NCPEFTSLCPITGQPDFANIIISYVPGEKMVESKSLKLYLFSFRNHGDFHEDCVNIIMK
                     DLIKLMDPKYIEVWGKFTPRGGISIDPYCNFGKPGTKWEEVAFNRMANHDMYPEKVDNR
                     "
     gene            complement(12982..13716)
                     /gene="pflA"
                     /locus_tag="BM306_RS00680"
                     /old_locus_tag="SAMN04487829_0135"
     CDS             complement(12982..13716)
                     /EC_number="1.97.1.4"
                     /GO_function="GO:0043365 -
                     [formate-C-acetyltransferase]-activating enzyme activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pflA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     deazapurine: QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005421749.1"
                     /locus_tag="BM306_RS00680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0135"
                     /product="pyruvate formate-lyase-activating protein"
                     /protein_id="WP_090152044.1"
                     /sec_met_domain="Fer4_12 (E-value: 6.6e-24, bitscore: 80.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.2e-10, bitscore: 37.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.3e-29, bitscore: 98.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIIGYINKFESFGAVDGPGVRYLIFLNGCKMRCAFCHNPETWA
                     EHQGEQYTADQVLEKAMRFKPYWKKDGGITVSGGEPLLQIDFVLDLFKKAKAKGITTCI
                     DTAGQPFTHEEPFYSKWKELMSVTDTVMLDIKNIDPEEHKKLTGVDNANILQMAQEISD
                     MGIRIWIRHVLVPGGSDNDELLHRTREFIDTLKTVERVEVLPYHSLGVPKYAELGIPYR
                     LEGVESPTPERIANAKEILGAF"
     gene            complement(14081..16339)
                     /gene="pflB"
                     /locus_tag="BM306_RS00685"
                     /old_locus_tag="SAMN04487829_0136"
     CDS             complement(14081..16339)
                     /EC_number="2.3.1.54"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008861 - formate C-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006113 - fermentation [Evidence IEA]"
                     /GO_process="GO:0015942 - formate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pflB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004848042.1"
                     /locus_tag="BM306_RS00685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0136"
                     /product="formate C-acetyltransferase"
                     /protein_id="WP_090485516.1"
                     /transl_table=11
                     /translation="MANHDFAQWNGFVGRVWKDNVDVRDFIQNNYTPYDGDESFLAGPT
                     DATNTLWGKLQELQAAERAKGGVLDMETEIVSSLTSYGPGYIAEETKDLEQIVGLQTDK
                     PLKRAFMPYGGIKMAEQSCKMYGYEPSEKLHEIFTVYHKTHNQGVFDIYTPEIMKARHN
                     KILTGLPDTYGRGRIVGDYRRVALYGIDYLIEKKQIDFANTNRQGMRRYDFQLREEITD
                     QINALKGMKEMAASYGFDISKPAANAKEAAQWLYFGYLAAIKTQNGAAMSVGRVSTFLD
                     IYFTRDLANGVITEAEAQEIIDHFTMKCRMVKFARIESYNQLFSGDPVWATLEVGGIGL
                     DGRHQVTKTCYRFLHTLENMGPSPEPNLTVMYSSRLPESFKKYAAKISVNTSSIQYEND
                     DVMRVTWGDDYSICCCVSATETGKELQFFGARANLAKCLLYAINGGIDEKSGDQVGPEY
                     TPITSEYLDYDEVMHKFDQMMDWLAHMYVGALNMIHYMHDKYYYEVCQMALIDTHVRRS
                     FATGIAGFSHCVDSLSAIKYAKVKAIRGENGVTTDFEIEGDFPRYGNDDDRADEIAVWL
                     LRTFMSKLRHIHTYRDSEPTTSILTITSNVVYGKATGALPDGRPAGEPLSPGANPAYGA
                     EKSGLIASLNSVAKLPYEEALDGISNTQTINPGALGHSEEERVNNLVNVLDGYFDQGAH
                     HLNVNVFGKEKLIDAMEHPEKPEYANFTIRVSGYAVKFIDLTKTQQLDVIARTCHEAL"
     gene            16725..17366
                     /locus_tag="BM306_RS00690"
                     /old_locus_tag="SAMN04487829_0137"
     CDS             16725..17366
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM306_RS00690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN04487829_0137"
                     /product="hypothetical protein"
                     /protein_id="WP_090485519.1"
                     /transl_table=11
                     /translation="MKKKLALMLATITTVAGLFTGCGEKDVHGKYEAKVGFSEMLSDDE
                     IKEMDEFAEYGLDFSGIEVKINLDLTEEGDFTLSYDGKAFKDDLSDTLENSMDGLIDAS
                     LEAAGISRDQLTDEMAQMYGYDSAQALFDDFSNQMVPYIEEGLDDLEKEVEEDTVTGTY
                     KVSKDSVVFVVEDGDDTSLKKGTINDDGTISITIEGDDDKSVDVVFELQK"
     gene            complement(17468..18370)
                     /locus_tag="BM306_RS00695"
                     /old_locus_tag="SAMN04487829_0138"
     CDS             complement(17468..18370)
                     /GO_function="GO:0004527 - exonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013122.4"
                     /locus_tag="BM306_RS00695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0138"
                     /product="exonuclease domain-containing protein"
                     /protein_id="WP_090485522.1"
                     /transl_table=11
                     /translation="MDKQNSNKSQSKKVKGPSQTAPAGFKGKNQAFLDAEYLSARYKKS
                     SIEDVISVGVIITNPEHKELDRFYSTVQLRPGHKLPPLITELTGLTNEELEFAPTYEEV
                     MTELINRIKAYQVGKICVWGGDKNSFQRDFESRVLEKPLKRSVAKFISTFENIQKEVSL
                     DITGGLDANLSLADMKTICGLGGLVEHNALSDAEDMLKCIRIIEQDQMVYDGVKAAEYK
                     KFRGEYVKNRSFNDEIEDKDYIIKSKLGEQFLKEIKSKGFEEDPKTKAFMDDLEFLLGK
                     GNVYMGTFSEKIEEENKKA"
     gene            18506..19081
                     /locus_tag="BM306_RS00700"
                     /old_locus_tag="SAMN04487829_0139"
     CDS             18506..19081
                     /EC_number="1.5.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008707992.1"
                     /locus_tag="BM306_RS00700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0139"
                     /product="flavin reductase family protein"
                     /protein_id="WP_090152034.1"
                     /transl_table=11
                     /translation="MAKEKWKAGNMIYPLPAVLVTCRSKSGEDNVFTVAWTGTVCTNPP
                     MAYISVRPSRYSYNMIKETGEFVINLTTEEMAKATDYCGVTSGRDVDKFQRCGLHKEEA
                     DEVNVPMLVESPVNIECRVREAHEYGSHTMFVADVICVHADEKYMNESGRFELEKSNPL
                     AYSHGTYFGLTSPKGTFGYSVKKGKKKK"
     gene            19078..20382
                     /locus_tag="BM306_RS00705"
                     /old_locus_tag="SAMN04487829_0140"
     CDS             19078..20382
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M42"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015548261.1"
                     /locus_tag="BM306_RS00705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0140"
                     /product="M18 family aminopeptidase"
                     /protein_id="WP_090485524.1"
                     /sec_met_domain="Peptidase_M42 (E-value: 5.8e-07, bitscore:
                     24.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTIKGLFDFIGKGPSQFHVVETERQAFLAAGFQELSESKSWKL
                     KAGKNYFVTRNGSSIIAFRMPKKEYESFMIIASHSDSPTFRIKEMPEMKEGHYVKLNTE
                     KYGGMLMAPWFDRPLSIAGRALVKGKNELQVKLVDLDKDLCMLPSLAIHMNREANDGYK
                     YNAQKDMLPLVSMNERFNLKELVAKHLDVKPEDIIGSDLFLYNREEGKVWGAEDEFISC
                     RRLDDLQCSYSSMEGILAAKNSETAVQLHATFDNEEVGSGTKQGADSTFLYDTLVRINE
                     SVGGNNSRLLSAIANSFMVSADNAHALHPNYSEKSDPTNKVYMNEGIVIKFNANQKYMT
                     DGLAFGIFTEICKKAKVPYQTFVNRSDVAGGSTLGNISNAHVSINGVDIGLAQLAMHSP
                     YETAGAKDTEYLVKLTKTFYETVIENQSGLAYTVK"
     gene            20428..21219
                     /gene="hisA"
                     /locus_tag="BM306_RS00710"
                     /old_locus_tag="SAMN04487829_0141"
     CDS             20428..21219
                     /GO_function="GO:0003949 - 1-(5-phosphoribosyl)-5-[(5-
                     phosphoribosylamino)methylideneamino]imidazole-4-
                     carboxamide isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000105 - histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015560052.1"
                     /locus_tag="BM306_RS00710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0141"
                     /product="phosphoribosylformimino-5-aminoimidazole
                     carboxamide ribotide isomerase"
                     /protein_id="WP_090485527.1"
                     /transl_table=11
                     /translation="MLFRPCIDIHNGKVKQIVGSTLSDLGKENGHPQENFVADKDAAYY
                     ADLYKKDGLRGGHIINLNKKNTPEYEASKAEAMKALSTFPGGIQYGGGVDDSNAKEFID
                     AGASHVIVTSYVFNNGRVDFEALRKLSGIVGREHLVLDLSCTRVDDKYYIVTDRWQKIS
                     KEIITYNFLDKLAFYCDEFLVHAADVEGRGSGIDRDLVGFLSGYKRVPITYAGGVHDYS
                     DIETISYLSDNNMDFTVGSCLDLFGGKLSYERIIKQISTRE"
     gene            21256..22470
                     /locus_tag="BM306_RS00715"
                     /old_locus_tag="SAMN04487829_0142"
     CDS             21256..22470
                     /EC_number="2.6.1.83"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (34-401). E-value:
                     6.9e-34. Score: 109.4. Matches aSDomain:
                     nrpspksdomains_BM306_RS00715_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015517297.1"
                     /locus_tag="BM306_RS00715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0142"
                     /product="LL-diaminopimelate aminotransferase"
                     /protein_id="WP_090485530.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.2e-32, bitscore:
                     109.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKVNTNFQKLPGSYLFSTIAKKVAAYSEANPNADIIRLGIGDVT
                     QPIAPAMISALHSAVDEMGDAKTFHGYAPDLGYPFLREAIAKNDYQARGCDISADEIFV
                     SDGAKSDSADIQELFSADARIAVCDPVYPVYVDSNVMAGRCGTYDEKSGKWSDIIYMPT
                     TAENHFVPEFPKETPDVIYLCLPNNPTGTTLTKSQLQLWVDYANKNGSLIIFDAAYEAY
                     ISEDDVPHSIYECTGARTCAIEIHSFSKNAGFTGVRLGYTVVPKDLVFDGVALHGMWAR
                     RHGTKFNGAPYIIQKAGEAVYSPEGKAQIKEQVGYYMNNAKTIYTGLKDAGFEVYGGVN
                     APYIWLKTPDKMTSWDFFDYLLEKVQIVGTPGAGFGPSGEGYFRLTAFGSAENTLRAIE
                     RIKNI"
     aSDomain        21358..22458
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM306_RS00715_Aminotran_1_2.1"
                     /evalue="6.90E-34"
                     /label="BM306_RS00715_Aminotran_1_2.1"
                     /locus_tag="BM306_RS00715"
                     /protein_end="401"
                     /protein_start="34"
                     /score="109.4"
                     /tool="antismash"
                     /translation="DIIRLGIGDVTQPIAPAMISALHSAVDEMGDAKTFHGYAPDLGYP
                     FLREAIAKNDYQARGCDISADEIFVSDGAKSDSADIQELFSADARIAVCDPVYPVYVDS
                     NVMAGRCGTYDEKSGKWSDIIYMPTTAENHFVPEFPKETPDVIYLCLPNNPTGTTLTKS
                     QLQLWVDYANKNGSLIIFDAAYEAYISEDDVPHSIYECTGARTCAIEIHSFSKNAGFTG
                     VRLGYTVVPKDLVFDGVALHGMWARRHGTKFNGAPYIIQKAGEAVYSPEGKAQIKEQVG
                     YYMNNAKTIYTGLKDAGFEVYGGVNAPYIWLKTPDKMTSWDFFDYLLEKVQIVGTPGAG
                     FGPSGEGYFRLTAFGSAENTLRAIERI"
     gene            22492..23205
                     /locus_tag="BM306_RS00720"
                     /old_locus_tag="SAMN04487829_0143"
     CDS             22492..23205
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012863.4"
                     /locus_tag="BM306_RS00720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0143"
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_090485533.1"
                     /transl_table=11
                     /translation="MFWAKYGKGFFKRKAVVVTFAILFVAGLLYHSGFLGGEDKRIRVT
                     CVGDSLTYGSGVLKTREINSYPAQLQTKLGPSYLVSNFGLRNGTASVTGNLPYINSGEY
                     ADSLKSKPDIVVLMLGTNDTKIINWDADEYKEGLSEIVASYLDLKTQPKVYLVRSPYCF
                     SVEGGELAEYGIQPAVVADELGQIAQEVASEYSLEYIDMYRVTDGKTDLYTSDGIHFNK
                     DGYQLISNTIYNVIK"
     gene            23327..23545
                     /locus_tag="BM306_RS00725"
                     /old_locus_tag="SAMN04487829_0144"
     CDS             23327..23545
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012743724.1"
                     /locus_tag="BM306_RS00725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04487829_0144"
                     /product="cation transporter"
                     /protein_id="WP_090152021.1"
                     /transl_table=11
                     /translation="MKKTYKIDVDCANCANKMEEAANNTAGVANAVVNFMALKMSVEFE
                     DGADTKSVMEEVLKNCKKVEDDCEIFL"
ORIGIN
        1 aaaagaccga ttacaccgcg ctttgcctca ccagttctga taagtaagat atttgtcttt
       61 ccaccttcag actgtggatt ctttaatccg tctacaagta acttgtctgt aggaatgatt
      121 gggattcctc tccaagctaa gaaagtgcct cctgcaatgt taacagtaac aggtggaacg
      181 cctctctttg tacattctct ctcgaatgca gcgattgcac gagggtgagc caagaagaat
      241 gaaggctctt tccaaacctt tgaaataagc tcatctaaat cgtctggagt aggtgcgccg
      301 tttcttgtct ggattctctg tgaatcagcg atattcttaa gaagaccata gtcatcattg
      361 ttgatgagct ggctttcctg tctctcgcgt aatgattcaa ttgcaagacc aagctgttcc
      421 tgaacctgat cataaggagc gctgtaaaca tcctcaattg cagtgttgac attgatgatt
      481 gtagaaatag agttgagtct gtattctctt ggctcagtct catactctac ataaccatca
      541 gggatgatgt cggacttttt agtctggctg caaagtacat cgagaggtgt ctccccctct
      601 acaaccttgt ttactctaaa aattcctgtc tcaagtccct tgaactcaag aagctttgtg
      661 agccactttg gtgtgagagc accgtactgt ggctttgtct ttgtgacatt ggcaaggtta
      721 tatgcggctt ttgcgccaag tgcattaatg ccttcctttg tctcaacatt ttcctttgac
      781 attttgttat cctcctttga atgttttgca tatataaagt cttatgacta tatgcctttt
      841 ttacagccaa gctccctcat gtgagaacat aatatcctta agggaatcaa tacctccttt
      901 taggttgtac attggtccat catagcctgc ctcacgaaga gtgttgatgg ctaggatact
      961 gcgcttgccc tccttgcata ggaagacagt tgggatttcc ggattaagtt ccccctttct
     1021 acgagcaagc tgaccaattg gaattactac cgcattaggg aagcggagaa ttgctcgctc
     1081 gtgaggttct ctaacatcta cgatggtaag agcctcgtcg ttttctatct tgcttgcgaa
     1141 ttcttcagct gtgaatcctt caactgggat ttcttcctca gcttctttca atccgcagaa
     1201 atcgtcataa tcaaaatttt ccaccttgat aatggatgga ttatcgccgc aaattgggca
     1261 cttatggctt ttggttacgg tgagcaggtt agagcgaagg tagaggctat ctactgtaag
     1321 cagcttgcct gaaagattct caccgatacc tataattagc tttagagcct cgttggcctg
     1381 aatgcttccc acaattccag gaagtgggct gatagcgcca ccttctgagc atgtaggaac
     1441 aagtcctgct ggtggtggag ctggaaatac acagcgatag catggcccac catttaaatt
     1501 aaatatgccc acctggccct cgtactgata aatggctccg aatacaagtg ggattccaat
     1561 gagagcgcaa gcgtcattta tcaaatatct agccttgtag ttgtcagtac aatcgattac
     1621 aagatcgtaa ccgtcgatta tttctactat attgtccgca tctaatttca cattttcagg
     1681 ctcaaagaca atgtttttat taatgttttt aaccttgtct ctagcagatg ctacctttgg
     1741 tcgttttaaa tcgcgagaag agtggagcac ctgattctgc aaattatcaa gggcaaccac
     1801 atcgaaatct actaccttta tagtgccaac ccctgcagca gctaagtact ggatgactgg
     1861 tgaaccaagg gctcctgcgc cgataactac cacctttgct gcctttattc tcttttggcc
     1921 cttaacaccg atgtctctaa gcatcaagtg cttcccgaag cgttcaactt ctgaatcgtc
     1981 aaaggaaact gcctttgctc gctcgtcaga tataatgctg tttttagggc tgccgccagc
     2041 aatagcagga agcagataaa catctcgacc tggtattaat gcatcactcc aagtagactc
     2101 atctgattta tttatgtccc ctacatatat ttggataaag ctccgaagat gcttgtcctc
     2161 atcgaatagt atttccttag aatctgggta ttcatctgta agccagtcaa gtattcctcg
     2221 gatattctca gcggggatat cgaatttatg attttttcca aagaatcctc gcaatgttgc
     2281 tgatatatat acgctcattt ctccactcct tatttcacgt ttatttccaa ttcttctatg
     2341 ccttcccaga tattctggcg aaaataagct tttacttgct tggtgccatc actggcaaca
     2401 gaggtgatac agtagttaag tttgggaatc atataggttt tatcttcctc agataaaata
     2461 gctgcagcat ctgggtgaga atggaagaat ccaataacat ctagatggtg gtgctgggcc
     2521 catttttcta tcatcagata gtccaatgag tcgattctga aactgtcagt ttctgctacc
     2581 aaattcggta gattacacac atcgtttact tgatttaagt cactgttgcc aagcaataca
     2641 ccgcaggcct catttggata ctgagcctca gagattgatg tcagcttaaa gaatgcttct
     2701 ttattaatct gcaacataaa tcacctcccc acacctatta actactaaac cagtaggtta
     2761 gtaggataat atcaaaaacc accaaaattc acaatatgtc tagttccaca gaaatcctat
     2821 agctaactat caataatttt gatagcagat gagacaggtt tttttatggg aaaatagcag
     2881 tgaaaaaaca acaaaaaatg tacaaagaac gcggaaaatg ctacacttag gttgttgttt
     2941 aaagcaaaag gatatgtgga ggaaatgaaa tgaaaatcgg ttttattgga actggaaaca
     3001 tgggcagcgc aatgatgggc ggtatggttt catcgggaat cgtggctgca tctaatgtta
     3061 tggctagcga tattttccag gctgcacttg atagaattag cgaccagtta aatattgcaa
     3121 caagcactaa taatcgtgat gttgtagatt ttgcagatat tgtattcttg gctgttaagc
     3181 ctcagtactt agctggagct attgacggaa tcaaggatat ggattttaca gataagattg
     3241 tagtcagcat tgcagcaggt cagtctattg aaaagcttac tgagcttttt ggcaagcagc
     3301 tcaagctcat ccgtgttatg cctaatactc cagcacttgt tggagaggct atgagtgcac
     3361 ttagtcctaa cgagcttgtt tcagaggatg aggctgacat cgtgcttcat ttatttgagt
     3421 catttggcaa ggccgagatc gtccctgaga aattgcagga tgctgtagtt ggtatcagcg
     3481 gttcttctcc agcttatgta tatatgttta ttgaggcact tgcagacgga gcagttgcag
     3541 agggcatgcc aagagcgcag gcatacaagt ttgcagccca ggctgtactt ggctctgcca
     3601 agatggtcct tgaaacaggt gagcaccctg gcgtacttaa ggatgctgta tgctcaccag
     3661 gtggcactac aatagaggca gttgctacac ttgaggctct tggattcaga aatgcagtta
     3721 ttgaagcaga gcgcgtttgc gttgagaagt ctagagattt gtaggattga cggggctgta
     3781 gcgttggcag gcttctaggt tttaatattg attaataatt ggatctctcc atgcgggata
     3841 agtaatcata tcccacgtgg ggagattttt tgtttatttc agtggcgaat ctgaggtcgg
     3901 ctactgccta gatagggaaa atggaaataa gcagtagcga ttttggagaa tgttactgcc
     3961 tagatgagaa aaatgagaat aagcagtagc gatttttgag aatgttactg cctagatgag
     4021 aaaaatggaa ataagcagta gcgattttgg agaatggtac tgcctagatg agaaaaatga
     4081 gaataagcag tagcgatttt gaaaaagggt actgcctgga tgagaaaaat agaaataagc
     4141 agtagaaatc aaaagaaggc tacagcctaa aatcgaaaaa taaatatagg cagtagaatt
     4201 tttaaaattt catgttgaca tacttcagct gtcgtagtat agtactgcga tagatagagt
     4261 actacggcag acgtagtacg acactaatag tatgacagac atagtaatat agcggaggaa
     4321 atattatgga tacaacagta actaagtgta atagtggaaa agtaaagaag actatatggc
     4381 agaaaatatt agattttcca ctagtaccac ttattgagat tgccattatt ggaataatag
     4441 gtaattttct aggcagaggt gtttctaatt tatttagacc atttgcaaat gagcaaaaca
     4501 ttgattctat tagattttta gcggcctatt tttcaacagc tggaactgtt atagctcagc
     4561 tgatttatat gtgggttgta aagcctcacc gtccaatgct taagacaatg ggaactagta
     4621 tctccggcaa caatataaag atggcattta taggtcttgt tgttggtttg gttatgaatg
     4681 gttctgcaat tttggtggca gccttacata aggatgtgaa gctgcatttt gctggaggca
     4741 gcctgctttt atttattctg ttattcatag ctgtactttt tcaggcgagc aatgaagaga
     4801 ttctctgcag atgcttctta tatcatcgtt ttaacaagat atttaaaaga ccagctgttg
     4861 ctatgtttat tgcctcaaca ctttttggat ttctacattt attaaatccg ggagtatcac
     4921 cccttgcaat tattaatgta gttcttgctg gactttggct tggacttctt atgtattgct
     4981 ttgacagtat ttggatggca atagctgcac accttggctg gaattattct caaagcatta
     5041 tctttggtct accaaatagt ggaaatgcat cagctttctc attattaaag tatgacatgg
     5101 catcagcaac aaatagcttt gcatacaatg tagactttgg tgtggaagga acagtgtttg
     5161 tatgcatcat gctgctagta atagattgtg gacttatcgt atatgcgata acaaagaaaa
     5221 agcagcctac agatgtgtat ctttaaagat tctttaagaa tttatttggt attgtgttat
     5281 ggaaattgga aatgaaagga ataggaagat gagtaagaaa aaatgtgtga taggaataat
     5341 tttagcaatg attttttcct ttggaatatc catggttgca tataatttat tcccagagaa
     5401 tacaattgct caagtgatat tggaagctat tgatgtggca ggtttgcttg gaataataat
     5461 tgcttttggt caaaagagag aattagggtt ttcagtaggc agtttcattg agggcattaa
     5521 gttaaatgct tatgtgcttg cctatgcggt tccatttttt atctatcatc ttgttgattg
     5581 gttgcttgga aatggaggcc cagattttta tgctaatacc attggttccg cgttaattct
     5641 ttttcttaca gctggaatgc gcgaggaatt actatttaga ggaattgctt ttaatttcat
     5701 taaagctaca ggtgaactta gtcgtccgat ggttattaaa gcttcagtta tttcagcact
     5761 cctttttgga attttgcatt tttcaaatta tttctttgga caggatttgc tttcaacatt
     5821 atgtcaggtg gtatatgcaa gtgccattgg aatattcttt gcagcggttt attttaggac
     5881 aaaaaatatt tgggccaata tagcagttca ctttttcttt gattttgccc atgtaaatat
     5941 ggaggaagtt ctaggggtaa aaggtaattt agtaggtgaa tccatgtcta ctttaattta
     6001 ttcaattgta actattgcag tagctttcta tcttatgaga gaaaagaaat tacagccagt
     6061 gcttcagggg taagaatcaa cagtaattta aatgacaggg aggatatttt caaatggtaa
     6121 atggagatat attttatttc tcttgggagc ttgattttct tcattggttg caggggattc
     6181 ataatccaat actggataaa ataatgatta ctgcaacaaa tctggaagat tatgttctaa
     6241 tattgctgtt aatttttata ggattaacag tttttcccag gagcagaaaa ataggtggga
     6301 cacttttagt ggcaacaatt gtttgttttt taatagtaaa cgttggaatg aaaccattta
     6361 taacaagatg caggccatgc tggcttgagc ccagcgtaaa gctacttgta aatgcacctc
     6421 atagtttttc attcccatcg ggacatacaa atgccttttt tgccatggca acagcagtat
     6481 ttttaaggaa taagaaaatc ggaattccat gtctagcaac agcgtctctt attgcattca
     6541 gtcgattata tttgtttgtt cattggccaa cagatgtatt aggtggaatt gttacaggaa
     6601 ttgttagtgc aataattgga tatatggcca tcgaagcatt aagtaaattg tttgggagaa
     6661 taaagaaaag aattaaggag aaaaaatatg aaaacaagtt tgagattaat taagtattta
     6721 ggagcaattg ttttatcatt tattttaatg acttttatac cgagtttggt actttcatat
     6781 ataaatatta ctaattatta tgttatggta agcgtttatt tattagtaat tatcgggatt
     6841 cttgctgtaa cagtaattgt atttggtgag aaaaaagtat ttgcgttttc acttaaaagt
     6901 ttcaaagata cctttgtaat tggtggtgtt atgacagcta ttacagcttt ttatttggtg
     6961 acaaatatct acacggcaat taaagagtat ggcacaccac ttatggatgg taagactata
     7021 gtgttatttc tattattaaa ttttctgggc gctggtatca gagaagagct tcttaccaga
     7081 ggtgtatggc ttacattctt tagaaaagct tttggtaaca gcaaggcatc atatatagtg
     7141 gcaatgtctt tatcttcgat tctttttggt gctattcata ttacaaatct tgatggagca
     7201 gttgacccta caccaattta cgcacagata atctatgcta ttggaatcgg atttttcctt
     7261 gcagcccttt attttagaac aggaaatctc tggggaaata tggtacttca cttccttttt
     7321 gatattagcc ttatggttaa gcctatgatt tacggaaata ggagcgatat ggatgtgctc
     7381 atcggagagt ggcttggctc aggaataatc ctcaagtcaa ttcttatttc ggtggtgtca
     7441 gttgttattg gtctttacct tattagaggc gacaaattca aggaaatcgc tgaggcagaa
     7501 taagtatgaa aaaattttta aaatatacac gcagattttt tatagtttca ctttgcttga
     7561 taatcgtttt actagtaact acatcgattg tatatagagt aaagcttcat aagataatga
     7621 acaccctaga accatgtagg tgtttggttt ctgctggaga atatgagtta aatgttgcta
     7681 gaattggcaa tagagatgga aaacataaaa ttgtatgttg ttctggatta aatgatggca
     7741 ctatgaatat ttcttggcgt aacatgacaa aatatattga aaaagataat gagctgttgt
     7801 ttatagaccg tgccggctat ggtcttagtg aggacaccaa ggaagataga accgtagatc
     7861 agatagtaga ggattatcga actgttctca aaaatctggg tgaggaaggt ccttatattt
     7921 tgatgggcca ctctattgga ggaatgtaca catcttactg gcagagcaag tatccagagg
     7981 aagtggaagg gctgataatc atggatggaa ccctttgcaa tttggttgat gaagaggaaa
     8041 aaacagcggc tgtaaaacag tggagatttc tctctatagc tgaaaaagtt gggcttgaac
     8101 cactagtaat gaaaaaatta tactataaga atcttctgga taatgtatca gatagagaag
     8161 cagactttca tttgtatttg ttttcaaaga ctacaggaag tcatgcaact atatcagagg
     8221 tgaatctagt ttacgataat gcccaggcag tatggaatag tctaaagcct aatgatgtac
     8281 caaagatttt tattgatgcc agctatcagg ttgctaacaa ttctgatttt gaaaaggatt
     8341 attggatacc atatgctgag aagatgggta attgcgatat tgtccctctt tatggtagtc
     8401 attctattta ctttgaaaag tcaaaggaat gtgggaatat tgttaagaat tttatcgctg
     8461 agttagatta agatttaaac tatttattga aaagaataaa gcatctgact ataatgaatt
     8521 cagcaaatta agaggatgaa tgattataga ttatggatgc agttaagaga tttattagaa
     8581 atgaaatagt actttgcgta gcttttgttt tggcggtgat atcagcattt gtgattcacc
     8641 cagacaaaag ctattttgct tacattgatt atagaaccct tagtattttg ctggcactta
     8701 tgattacaat ggcagggctt cagagacttc atgtttttag acagatagga gagcttttgg
     8761 ttgcaaagat gagctcgata agaggagtta ctcttattct cattgccctt tgctttttct
     8821 ctgctatgtt tattacaaat gatgtggccc ttcttacatt tgtgccattt tcgattgtaa
     8881 ccttatctat ttctggaaga aaagatctct acataatagt gatagtgcta gagacaatag
     8941 ctgcaaacct tggaagtatg ctgactccac taggcaatcc acagaattta tatctatact
     9001 cgattgctgg aatgagcctt ggggcattta taaaattaat gcttccatat agtgtggtag
     9061 ctcttgcaat gcttgtgatt gcaaccgtta tcagagtgaa gagcgctcct gttgttctta
     9121 cagaaaagag cgtatatgag cgtaaagctc gggataagaa gctaattgcc atgtacgtat
     9181 ttacgttttt ggtttctatt ctagtggttg ccagagtgct tgattatcga attggacttt
     9241 taatagttgc gttgcttgca tttatctttg ataggagagt tctcagaaag ccagactatt
     9301 ctcttttatt tacctttatc ttcttattta tatttatagg aaatattaag aggattcctg
     9361 aacttagtgg agcccttagt cagcttgtta aggtaaatga ggtgggagtg tctattggac
     9421 ttagccaggt gattagcaat gtgcctgcag caattttatg ctctggattt acagaccaga
     9481 ttgacaagct tatcattgga accaatcttg gaggtctggg aacacttata gcttctatgg
     9541 caagtctcat ttcattcaaa cagtacagct atattgatgg ttcagattct aaaaaatata
     9601 tgatagtgtt caccgctttt aatattatct ttttagcagt aatgtgtgca ctgtatttat
     9661 taatgtaaga gttgtaagct gctttatgat taataaattg gcggtagata gaaatgttaa
     9721 gtattgactt gattttttct tgcttaggga gtattatagt caagcaattt aaaagagaaa
     9781 ttcgcctacg ggcgagggac agttcgtttg taccatcctg tccataaaca aaaccaggac
     9841 taaaaagtaa tttagatgac tcagtatgtt tgggtttatt tgaatcgatt atgattagtt
     9901 ggtaaagaag gggtgcactc ttcttttttt attgtttatc tttagttttc catcctaatc
     9961 atatccagtt ttttctagtc ctgtttcaag gagattttca atgtactatt taactgcaga
    10021 agcttcattt gatggagcac actttctagc tggctatgag ggcaaatgct caaatttgca
    10081 cggtcatcgc tggagagtaa ttttaaatat aaagtctgaa aagttgcagg ctgagggcca
    10141 gcaacgagga atggttgtag atttcggcga tgtaaaaagt gctcttaaaa aagagactga
    10201 ttactttgat cacaccttta tatatgaaga aggttctctt aaggatacaa cagttgccgc
    10261 tcttaaggac gagaatttcc ttatgagagt agtgcctttt agaccaacag ccgagaattt
    10321 ttccaagtat ttttatgaga agtttacttc atacggattt aaggtggcag aggtgacagt
    10381 ttacgagact cctaataact gcgctagcta cagggaggat taattgtggc tgtttttaat
    10441 gtagtagaaa aattcgtaag tataaatggc gaagggcagc atgctggcga gcttgcggta
    10501 ttcataaggc tccgtggatg taatctctca tgtagctatt gtgatactag atgggcctgc
    10561 actgatgaag ctgatgctga ggcgatgagt gaggacgaaa tcatctcata tgttaagtcg
    10621 acgggagtga gaagagttac cctgacaggt ggagaaccct tgctggcaga ggatattgga
    10681 gtgcttttag aagccttttc tagtgagaaa aatttcctag ttgaaataga aaccaacggt
    10741 agtgttttcg taggggattt tgcaaaaata gataaccctc cagcctttac tttggactat
    10801 aagcttgctg gttctggcat ggaagataag atggatctta gtaatttcaa gtatttgcaa
    10861 aagaaggata cggtgaaatt tgtctgctct aatgtgtcag agcttgataa ggtctgtgaa
    10921 atagtggatg agttttcact gtcagagaaa tgtacagtgt taattagccc tgtgtttggt
    10981 agaatcgagc cggcagatat ggtggactat ttaataaaac acaaacgtaa cgatataaga
    11041 ttgcagctac aacttcacaa gtttatttgg gacccaaata agcgaggagt ataggaaggt
    11101 aaaatatggc aattaataag gaattaataa aggaaagcat tagaaatatc ataattgcgc
    11161 tgggagatga ccctgataga gcaggacttt tagagacacc ggaccgtgtg gctcgtatgt
    11221 acgaggaagt ctttgaggga atgaattaca gcaatgctga gatagcagat atgtttaaca
    11281 aaacatttga cgaggactac tatgatgagg atagtcagga tttggtgttt gttaaggata
    11341 tagaggtgtt tagctactgc gagcatcacc ttgcccttat gtatgatatg aaggtaagcg
    11401 tggcatacat tccaaatgga aaagtaattg gacttagcaa aatcgcaaga attgctgaca
    11461 tggcggcaaa gcgccttcag cttcaggagc gtatcggaaa tgatatagca gagattctgc
    11521 aaatggtgac aggctcagag gatgtggctg tatttattga agcaagccat tcgtgcatga
    11581 cagcccgtgg catcaaaaat gcgggagccc gcactcatac tcagacctta agaggtcgat
    11641 ttaaaaccga cagtgattta cttgctagat tacattaatc gcggtattag gaggatttat
    11701 ataaataatg aaagctttag ttttagttag cggtggagtg gatagcacta cttgccttgg
    11761 aatggctgta aaggaatatg gccatgaaaa tgttgttggc ctatctattt tttatggaca
    11821 gcgccatgat aaggagataa aggcagcaga tgctgtgtgc gatttttata aggtagagca
    11881 tattacactt gatttatcta caatgtttca gtttagcgac tgcacattgc ttcagcattc
    11941 tgacggtgag attccagaag agtcatacgc agagcagtta tcaaagacag atggcaagcc
    12001 agtaagcact tacgtaccat ttagaaatgg acttttcctt tctagtgcca gtgcaattgc
    12061 actttctaag ggatgctcaa aaatctatta tggggctcac agtgatgatg cagctggcaa
    12121 tgcttatcca gattgttcag aggcatttaa caaggctatg aacacagcta tttacgaggg
    12181 cagtggcaag cagcttgaaa ttgtagcacc atttatcagt cttaacaaat cacaggttgt
    12241 aaagaagggc cttgagattg gcgtacctta tgagcttaca tggagctgct atgagggcca
    12301 tgagaaagct tgcggaaaat gtggtacatg catcgacaga aaggcagcat ttgagttaaa
    12361 cggggtaaaa gaccctatag aatatgaaaa ttaattatcg taaatacgaa aggaatcaat
    12421 tatggcagat agagcagcag agggaacact tacccttctt ggaaacaaaa acaatgtata
    12481 cccagacaac tatgcacctg agatgcttca gaccttttta aacaagcatc cagagaatga
    12541 ttattttgta aaattcaatt gtccagaatt tacatcactt tgtcctatta cagggcagcc
    12601 tgattttgct aatattatca tttcatatgt tccaggtgag aagatggtag agagcaaatc
    12661 tctcaagcta tatttattca gcttcagaaa ccatggagat ttccatgagg attgcgtaaa
    12721 tataataatg aaggatttaa tcaagcttat ggaccctaag tacattgaag tatggggcaa
    12781 attcactcca agaggtggta tttcaatcga cccatattgc aattttggta agccaggaac
    12841 taaatgggaa gaagtagcat ttaaccgtat ggcaaatcat gatatgtatc cagaaaaagt
    12901 agataataga taacttattg cattaagaaa ccccttattg agtttaggtc aataaggggt
    12961 tttgtttaat tattaaaatg attaaaatgc accaagtatt tccttggcat tggcaattcg
    13021 ctcaggagta ggagactcaa caccctcgag acggtatgga atgccaagct cagcgtattt
    13081 tggaacaccg agactgtggt aaggaagaac ctcaacacgc tctacagtct taagagtatc
    13141 aataaactcg cgtgtgcgat gtaaaagctc atcattgtca ctgcctcctg gcacaagtac
    13201 gtggcgaatc caaatacgaa tacccatatc tgagatttcc tgagccatct gaagaatatt
    13261 ggcattgtca acaccagtaa gcttcttgtg ctcctcagga tcgatatttt taatatcaag
    13321 cattactgta tcagtaacac tcataagctc tttccatttg ctataaaatg gctcttcgtg
    13381 agtgaaaggc tgacctgcag tatcgatgca agttgtgatt ccttttgcct tggctttctt
    13441 aaataaatcc aatacaaaat caatctgaag aagtggctcg ccaccgctga cagtgatacc
    13501 gccgtccttt ttccaatatg gcttgaagcg catagccttc tcaagtacct gatcagcagt
    13561 atactgctca ccctggtgct cagcccatgt ctctggattg tgacaaaaag cacatctcat
    13621 cttgcagcca tttaagaaaa tcaaatatct aacgcctggt ccatcaacgg caccaaagct
    13681 ctcaaactta ttaatgtatc ctataatttc actcatatcg tacctcattc taaaatccac
    13741 gactcgtcgt gagtaaatat ataagcacta tagatacgct tgcgctctta ttcgctcctt
    13801 acgttacata agatgctgct agcgcaccat ctaagtaacg agggctcata aaggccttat
    13861 agttgcttat atatttattc acttgagtct tagttaaaaa taaaagccca agtatataaa
    13921 tgagtacatt aagctgacct taaagcgcac tcgttacttg aatccgcaga gcggattctt
    13981 atgtaacgtg agtagcgcga caagagcgaa agcgtgtcag cgaatgtgct ctttatatac
    14041 gtagggcttt ataggttagc cacaaagcag tggtgttata ttaaagagcc tcgtggcatg
    14101 tacgtgcgat aacgtcaagc tgctgagtct ttgttaagtc gatgaactta acagcgtatc
    14161 ctgatacacg gattgtgaag ttagcgtact caggcttctc tggatgctcc atagcgtcga
    14221 tgagcttttc cttaccaaat acgttaacgt taaggtgatg agcaccctga tcgaagtaac
    14281 catcaagaac gttaacaagg ttgtttacgc gctcttcctc agagtgacca agtgcacctg
    14341 ggttgattgt ctgtgtatta gagataccat caagtgcctc ttcgtatgga agcttagcaa
    14401 cagagttaag agaagcgata agaccgctct tctcagcacc gtatgctggg ttagcacctg
    14461 gtgaaagtgg ctcgcctgct ggtcttccgt ctggaagagc acctgtagcc ttaccgtata
    14521 ctacgtttga agtaattgta aggatagatg tagtaggctc tgaatctcta tatgtgtgga
    14581 tgtgacgaag cttgctcatg aatgtgcgga gaagccatac agcaatctca tcagctctgt
    14641 catcatcgtt accgtaacgt gggaagtcac cttcgatttc gaaatctgta gtaacaccat
    14701 tctcgccacg gatagcctta acctttgcgt acttgatagc tgaaagtgaa tctacacagt
    14761 gtgagaatcc agcgatacct gtagcaaatg aacggcgtac gtgtgtatca ataagtgcca
    14821 tctggcatac ttcatagtaa tacttatcat gcatgtagtg gatcatgtta agtgctccaa
    14881 catacatgtg agctaaccaa tccatcatct gatcgaactt gtgcataacc tcatcatagt
    14941 caaggtactc agatgtgata ggtgtgtact ctggtccaac ctgatcgcca gacttctcat
    15001 cgataccacc attgatagcg taaagaagac acttagcaag gttagcacga gcaccgaaga
    15061 actgaagctc cttacctgtc tctgtagcag atacacagca gcagattgag taatcatcgc
    15121 cccatgtaac tctcataaca tcatcgttct cgtactggat agaagatgtg ttaactgaga
    15181 tcttagcagc gtacttcttg aatgactcag gaagacggct agagtacata actgtaaggt
    15241 ttggctctgg tgaaggtccc atgttctcaa gtgtgtgaag gaatctataa catgtctttg
    15301 taacctggtg acgaccatca agaccgatac caccaacctc aagagtagcc catactgggt
    15361 cacctgagaa taactggttg taagactcga tacgagcgaa cttaaccata cggcacttca
    15421 ttgtgaagtg atcgatgatc tcctgagcct cagcctctgt gataacgccg ttagcaaggt
    15481 cacgtgtaaa gtagatatca aggaatgtag aaacacgacc tactgacata gcagcaccgt
    15541 tctgagtctt gatagctgca aggtaaccga agtataacca ctgagcagct tccttagcgt
    15601 tagcagctgg cttagaaata tcgaagccgt aagaagcagc catttccttc atgcccttaa
    15661 gagcgttgat ctggtctgtg atctcctcac gaagctggaa gtcataacgt ctcataccct
    15721 gacggtttgt gttagcgaag tcgatctgct tcttctcgat aaggtaatca ataccgtaaa
    15781 gagcaactct tctgtaatcg ccgacgatac gtccacgacc gtatgtatct ggaagacctg
    15841 taaggatctt gttgtgacgt gccttcatga tctcaggtgt gtagatatcg aatacaccct
    15901 ggttatgtgt cttatgatat actgtaaaga tttcgtgaag cttctcgctt ggctcatagc
    15961 catacatctt gcaagactgc tcagccatct tgataccacc gtaaggcatg aatgctctct
    16021 taagtggctt atctgtctga agacctacga tctgctcgag atcctttgtc tcctctgcga
    16081 tgtaacctgg gccataagaa gtaagagatg aaacaatctc tgtctccatg tcaagtacgc
    16141 cgcccttagc acgctcagct gcctgaagct cctggagctt gccccagaga gtgttagtag
    16201 cgtctgtagg acctgctaag aatgactcgt ctccatcata tggagtgtag ttgttctgga
    16261 tgaaatcacg tacgtctacg ttatctttcc aaacgcgacc tacgaatccg ttccattgtg
    16321 cgaaatcgtg atttgccatt ttattatcct ttcattgttt aaggtttata gttgtgagct
    16381 agtggggttg tgttaaaatt ttatcaatca agttagataa aactaacacc ttagctcata
    16441 ttcactataa cataactctg ataaaaattt cacaatgtat ttgaataaat acataataaa
    16501 aatgtattta tctaaataca aaaaaatata ggcaataaac aatagttggt ggggaatatt
    16561 ccatatgaac taggcggatt ttaactacta tattatatat taaatgggga gataaatttt
    16621 ttaaaaagta ttaaattaat actttactaa tatgattttt tatgatacat tatccctgtg
    16681 ctaaaaattg atactaaaaa ataatttatt taaggagtag aaatatgaaa aagaaattag
    16741 ctttaatgct agcaacaatc acaactgttg caggtctttt cacaggttgt ggagagaagg
    16801 atgtacatgg aaagtatgag gcaaaggtag gcttttcaga aatgcttagt gatgatgaga
    16861 tcaaagagat ggacgagttt gctgaatatg gtcttgattt ttctggtata gaggtcaaaa
    16921 ttaatcttga tcttacagaa gaaggagatt ttacactctc atatgatggt aaagcattta
    16981 aggatgattt atcagataca cttgagaata gtatggatgg tcttatcgac gcatcattgg
    17041 aagcagctgg tatttcaaga gatcaattga cagatgaaat ggcacagatg tatggatatg
    17101 attctgcaca ggctttattt gatgattttt ctaatcaaat ggttccttat attgaggaag
    17161 ggttagacga tttagaaaaa gaagtagaag aggatacagt tactggaaca tataaagttt
    17221 ccaaggattc tgtagtattt gttgtagaag atggtgatga cacaagcttg aaaaagggca
    17281 ctataaatga tgatggcact atttcaatca ctattgaagg cgatgacgat aagtctgttg
    17341 acgttgtttt tgagttacag aagtagataa tcaattatta agtgcttaat aatacgcatt
    17401 atgaagggct ttctgaaata aaataaaaac cgtggatgta tttttagata ttacacccac
    17461 ggttttatta tgctttttta ttttcttctt caattttctc ggagaatgtt cccatgtaaa
    17521 catttccttt gccaagtaaa aattccaggt cgtccatgaa ggcctttgtc ttaggatcct
    17581 cctcaaagcc cttggacttg atttctttta agaactgctc cccaagcttt gacttgatga
    17641 tgtaatcctt gtcttcgatt tcatcattga agcttcgatt tttgacgtat tcgccacgga
    17701 atttcttgta ttcagcagcc ttgacaccat cgtaaaccat ctggtcctgc tcgatgatgc
    17761 ggatgcattt gagcatgtcc tcagcatcgg atagggcgtt gtgctcaaca agtccgccta
    17821 gaccgcagat agtcttcata tctgcaaggg aaagattggc gtctaatcca cctgtaatat
    17881 cgaggctgac ttccttttgg atgttttcaa aagtgctgat gaacttagca acacttcttt
    17941 ttagtggctt ctcaagaact cgagactcga agtctcgctg gaagctattt ttgtctccac
    18001 cccagacgca tatttttcca acctgatatg cctttatgcg attgatgagc tccgtcatta
    18061 cctcctcata ggtaggggca aactccagct cctcattggt aagacctgta agctctgtga
    18121 taagtggtgg gagcttatga ccagggcgaa gctgaacagt agaatagaat ctatcaagct
    18181 ccttgtgctc tgggttggtg ataataacgc caactgaaat gacatcttcg atagaactct
    18241 ttttatatcg ggcgcttaaa tactcggcgt ccaaaaaggc ctgattcttg cccttgaaac
    18301 ctgcaggtgc agtctggcta ggacctttaa cttttttcga ttgtgattta ttcgagtttt
    18361 gcttgtccaa aattatctcc atttataaaa catatttgat gattcattgt accatgtaaa
    18421 cctcttaaat gtaaaatgaa caccctgtta tttatagaag atttaaggta tagtaaaaag
    18481 cgtaagaaat taacgggagg tcagtatggc taaggaaaaa tggaaagcgg gaaatatgat
    18541 ttatcctctt ccggcagtgc ttgttacctg cagaagcaaa tcaggtgagg ataatgtttt
    18601 tacagtggct tggactggca cagtctgcac caatccgcct atggcatata tttccgtacg
    18661 acctagcaga tattcttata acatgattaa agagacaggt gaatttgtga ttaatctcac
    18721 cactgaggag atggctaagg ccacagatta ttgtggcgtc accagtggaa gagatgtgga
    18781 caagtttcag cgctgcggtc ttcacaagga ggaggcagac gaggtgaatg tcccaatgct
    18841 tgttgagtcg cctgtaaaca tagagtgtag agtccgtgag gcccatgaat atggcagcca
    18901 taccatgttt gtggcagatg tcatttgcgt acatgcagat gagaaataca tgaatgagtc
    18961 gggtagattt gagcttgaaa aatcaaatcc cctcgcatac tctcacggca catattttgg
    19021 attgactagt ccgaagggga cttttggata ttctgtaaag aaaggaaaaa agaaaaaatg
    19081 aataagacaa taaaggggtt atttgatttt ataggcaagg gaccatctca gtttcatgtg
    19141 gtagagactg agcgtcaggc atttttggca gctggttttc aggagctttc cgagtcaaaa
    19201 tcatggaagc ttaaggcggg caagaactat tttgtcacaa gaaatggttc ttcgatcatt
    19261 gcttttagaa tgcctaaaaa agaatatgag agctttatga ttatcgcttc tcacagcgat
    19321 tctcctacat ttagaatcaa ggaaatgcca gagatgaagg agggccacta tgtaaagctc
    19381 aacacagaaa aatatggtgg aatgcttatg gctccttggt ttgacagacc tctttccatt
    19441 gcaggtcgtg ctctcgttaa ggggaaaaat gagcttcagg taaagcttgt ggatttggat
    19501 aaggatttgt gcatgcttcc ttctcttgct atccacatga atcgagaggc caatgatggt
    19561 tacaaataca acgcgcaaaa ggatatgctt ccacttgttt caatgaatga aaggttcaac
    19621 ctaaaggagc ttgtggctaa gcacctagat gtaaagcctg aggatatcat tggctctgat
    19681 ttgttcttat ataatagaga agagggcaaa gtctggggag cagaggatga gtttatttcc
    19741 tgcagaagac ttgatgattt gcagtgttct tacagttcta tggaaggtat tctcgctgct
    19801 aaaaattcag agacggcggt acagcttcac gctacatttg acaatgaaga agtaggaagt
    19861 ggaacaaagc agggtgctga ttctacattt ttatatgaca ctttagtacg tataaacgaa
    19921 tctgttggtg gcaataattc aagactttta tctgctatcg caaattcatt tatggtatct
    19981 gcagacaatg ctcacgctct tcatcctaat tattctgaaa agagcgaccc tacaaacaag
    20041 gtgtacatga acgagggtat tgttatcaag ttcaacgcta atcaaaaata catgacagat
    20101 gggctggcat ttggaatttt cactgaaatt tgcaaaaagg caaaggtgcc ataccagaca
    20161 tttgtaaacc gttctgacgt ggctggaggc tctacacttg gcaacatttc caacgcccat
    20221 gtttccatca acggagtgga catcggattg gctcaattgg ccatgcattc gccatatgag
    20281 acggctggtg caaaagatac agaatattta gtaaaattaa cgaaaacttt ttacgaaact
    20341 gttattgaaa atcaatcagg ccttgcttat actgtgaagt gatttttata aaaagtacga
    20401 ttaaacaggc aaatatgggg gcttgagatg ttatttagac catgcatcga cattcacaat
    20461 ggcaaagtaa aacagatagt tggttctaca ttatctgacc ttggaaagga aaatggacat
    20521 ccacaggaga attttgtggc ggataaggat gctgcttatt acgctgattt atacaaaaaa
    20581 gatggacttc gtggaggcca cattatcaat cttaataaga aaaatacacc agaatatgag
    20641 gcttctaagg cagaggctat gaaggcgtta tctacatttc caggtggcat tcagtatggc
    20701 ggtggtgtgg atgattccaa tgcaaaagaa tttattgatg caggggctag tcatgtcata
    20761 gttacttcgt atgttttcaa taatggccga gttgattttg aggctcttag aaagctttct
    20821 ggaattgtgg gtagagagca tttagttctt gatttgtcat gcactagagt tgatgacaaa
    20881 tactacattg tcacagatcg ttggcaaaag atttcaaaag agattattac atacaatttt
    20941 ttagataaat tggcattcta ctgcgatgaa tttttggttc atgcagcaga tgttgagggg
    21001 agaggaagtg gcatagatag agatttagta ggatttttat ctggctacaa gagggtgcct
    21061 attacatatg ctggcggtgt tcacgattat agtgatattg aaaccatcag ctatctttct
    21121 gataacaata tggatttcac tgtaggttca tgtcttgatt tgttcggcgg aaagctttcc
    21181 tacgagagaa taattaagca gatttctact agagaataaa atacatttca taattattag
    21241 aaataggagg caacgatgtt taaggtaaac actaattttc aaaagctacc aggtagctat
    21301 cttttctcaa caatagccaa gaaagtggct gcttatagcg aggctaatcc aaatgctgac
    21361 attatcagac ttggtattgg cgatgttact cagccaatcg caccagctat gatttctgct
    21421 cttcacagcg cagtagacga gatgggcgac gccaagactt tccacggata tgcacctgat
    21481 ttaggttatc cattccttcg cgaggcaatc gctaagaatg attaccaggc aagaggttgt
    21541 gatatttccg cagatgagat ttttgtttct gatggagcaa agtctgattc agctgatatt
    21601 caggagcttt tctctgcaga tgctcgcatt gcagtttgtg atcctgttta tccagtttat
    21661 gttgattcaa atgtaatggc tggtcgttgt ggcacttatg atgaaaagtc tggcaagtgg
    21721 tcagatatta tctatatgcc tactacagct gagaatcatt tcgtgccaga gttccctaag
    21781 gagactccag acgtaattta tctttgcctt ccaaacaatc ctactggaac tactcttaca
    21841 aagagccagc ttcagctttg ggttgattat gctaataaaa atggcagcct cattattttt
    21901 gatgcagctt atgaggctta tatttcagag gatgatgttc ctcattcaat ctatgagtgt
    21961 actggtgcaa gaacttgcgc aatcgagatt cactcattct ctaagaatgc gggatttaca
    22021 ggcgtacgtc ttggatacac tgtagtacct aaggatttag tatttgacgg tgttgctctt
    22081 cacggaatgt gggctcgtcg tcatggcaca aagttcaacg gtgctccata tattatccag
    22141 aaggctggcg aggctgttta ttctccagag ggcaaggccc agattaagga gcaggttgga
    22201 tattacatga acaatgccaa gacaatttac acaggtctca aggacgctgg cttcgaagta
    22261 tacggtggtg taaatgcacc ttatatttgg cttaagactc ctgataagat gacatcatgg
    22321 gatttctttg attacttatt agagaaggtt cagattgttg gtacaccagg tgctggtttt
    22381 ggaccttcag gcgagggcta ctttagactt acagctttcg gttctgctga gaacacactc
    22441 agagctatcg agagaattaa aaacatttaa tattaagaga ggcatcgata gatgttttgg
    22501 gcaaaatacg gtaagggatt tttcaaaaga aaagcggttg tagtaacatt tgcaattctg
    22561 tttgttgcag ggcttttgta ccattctggc tttttaggcg gagaggacaa gagaataaga
    22621 gtgacctgtg tgggcgatag tttgacatac ggtagtggtg tgcttaaaac tcgagagatt
    22681 aatagctatc cagcacagct tcagacaaag cttggtccat cttatttggt atccaatttc
    22741 ggacttagaa atggtacagc ttccgttaca ggaaatttgc cttatatcaa ttcgggagag
    22801 tatgcagatt ctctcaaatc aaagcctgat atagttgttc ttatgttggg taccaatgat
    22861 acgaagatta ttaattggga tgctgatgaa tacaaagagg ggctttcaga gattgtagct
    22921 tcctatttag atttgaaaac acagcctaag gtttacctag ttcgtagtcc ttattgtttt
    22981 tcagttgagg gcggagaatt ggctgagtac ggcatacagc cagctgttgt ggctgatgaa
    23041 ttgggccaga tagctcagga agtggcttcg gagtattcct tagaatatat cgatatgtat
    23101 cgggttactg atggtaagac cgacttatat acatcggatg gtattcattt taacaaggat
    23161 ggatatcagc tcatttccaa tacaatctat aatgtaatta aataaaatgt taaataatta
    23221 tgaaacccgt tgacagatta tgttaacggg tttatattta tatcaacaca tgaacaatta
    23281 ttcatacgtt cagatgaaaa tataaattct atggaggaaa aaagatatga agaagactta
    23341 caagattgat gttgattgcg caaactgcgc taacaagatg gaggaggctg ctaacaacac
    23401 agcaggtgtt gctaatgcag tagttaattt tatggcattg aagatgtctg ttgaatttga
    23461 agatggagca gacacaaagt cagttatgga agaggttctt aagaactgca aaaaggtaga
    23521 ggatgattgc gagattttcc tttaattagt tattttgatt ggagttagct atgaacaaga
    23581 agcaaaagaa ggtcttaaca agaataataa tagcatcagt gttgatggta attttggtct
    23641 tactgccact tgaggattat ccattggtgc gtttcatatt atttatggtt ccatatttta
    23701 ctgtgggcta cgatat
//
