GCF_900112385.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_FOLK01000001.1 (Streptococcus equinus (Streptococcus bovis))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	T3PKS	161,051	202,226

NZ_FOLK01000002.1 (Streptococcus equinus (Streptococcus bovis))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	terpene-precursor,lanthipeptide-class-ii	355,656	389,117	Medium	streptococcin A-FF22	ribosomal:RiPP:Lanthipeptide

NZ_FOLK01000003.1 (Streptococcus equinus (Streptococcus bovis))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	RiPP-like	1	10,977

NZ_FOLK01000004.1 (Streptococcus equinus (Streptococcus bovis))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	arylpolyene	44,790	86,982

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	T3PKS	161,051	202,226
Region 3.1	terpene-precursor,lanthipeptide-class-ii	355,656	389,117	Medium	streptococcin A-FF22	ribosomal:RiPP:Lanthipeptide
Region 5.1	RiPP-like	1	10,977
Region 6.1	arylpolyene	44,790	86,982

No secondary metabolite regions were found in these records:: NZ_FOLK01000011.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FOLK01000014.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FOLK01000012.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FOLK01000006.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FOLK01000007.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FOLK01000013.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FOLK01000005.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FOLK01000008.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FOLK01000009.1 (Streptococcus equinus (Streptococcus bovis)); NZ_FOLK01000010.1 (Streptococcus equinus (Streptococcus bovis))

Compact view

NZ_FOLK01000001.1 - Region 1 - T3PKS

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Location: 161,051 - 202,226 nt. (total: 41,176 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

BM262_RS00895: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

BM262_RS00985: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Isomerases: isomerase

BM262_RS00800: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: synthase

BM262_RS00890: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Translocases: permease

BM262_RS00865: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000016.4	0.43	other (other)	amphotericin B	Streptomyces nodosus
BGC0000883.5	0.43	other (other)	arginomycin	Streptomyces arginensis
BGC0002707.2	0.41	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0001080.5	0.41	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000934.4	0.41	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000527.5	0.41	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002031.3	0.41	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0001789.3	0.41	ribosomal	suicin 90-1330	Streptococcus suis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000016.4	0.43	other (other)	amphotericin B	Streptomyces nodosus
BGC0000883.5	0.43	other (other)	arginomycin	Streptomyces arginensis
BGC0002707.2	0.41	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0001080.5	0.41	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000934.4	0.41	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000527.5	0.41	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002031.3	0.41	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0001789.3	0.41	ribosomal	suicin 90-1330	Streptococcus suis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.52 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.54 out of 27.78

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.69 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.73 out of 26.06

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.05 out of 21.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.52 out of 28.19

Confidence: strong

Additional weak hits (4):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 27.09 out of 31.73

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.95 out of 30.11

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.21 out of 39.62

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.75 out of 29.38

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_FOLK01000002.1 - Region 1 - lanthipeptide-class-ii,terpene-precursor

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Location: 355,656 - 389,117 nt. (total: 33,462 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carbamoyltransferase

BM262_RS05710: ornithine carbamoyltransferase

smcogs: SMCOG1114: ornithine carbamoyltransferase

Lyases: cyclase

BM262_RS05665: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthetase

BM262_RS05610: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000547.5	0.59	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000557.5	0.56	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0000532.3	0.49	ribosomal	mutacin II	Streptococcus mutans
BGC0000562.3	0.47	ribosomal	variacin	Kocuria varians
BGC0001788.3	0.47	ribosomal	suicin 65	Streptococcus suis
BGC0000521.3	0.47	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000539.5	0.43	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000526.5	0.42	ribosomal	macedocin	Streptococcus macedonicus
BGC0000527.5	0.35	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000626.3	0.35	ribosomal	thuricin	Bacillus thuringiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000532.3	0.78	ribosomal	mutacin II	Streptococcus mutans
BGC0000562.3	0.77	ribosomal	variacin	Kocuria varians
BGC0000547.5	0.72	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000557.5	0.70	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0001788.3	0.66	ribosomal	suicin 65	Streptococcus suis
BGC0000521.3	0.63	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000499.3	0.61	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens
BGC0000526.5	0.61	ribosomal	macedocin	Streptococcus macedonicus
BGC0000539.5	0.59	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.55	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for BM262_RS05665

BM262_RS05670

Leader:

MKNTNIIDIKATEALQELSLEELDTIIGA

Core:

KKGSGVVPTVSHDCHMNSWQFLFTCCS

Core with dehydrations:

KKGDhaGVVPDhbVDhaHDCysHMNDhaWQFLFDhbCysCysDha

antiSMASH-DB 4.0 matches for BM262_RS05670

100.0%

NZ_CP046629.1and 3 others:

NZ_FNJX01000002.1 Lanthipeptides: BLR40_RS05025_lanthipeptideNZ_FNZS01000001.1 Lanthipeptides: BMX70_RS03125_lanthipeptideNZ_FOLK01000002.1 Lanthipeptides: BM262_RS05670_lanthipeptide

Lanthipeptides: GPA00_RS05740_lanthipeptide

KKGSGVVPTVSHDCHMNSWQFLFTCCS

85.2%

NZ_CP051645.1and 2 others:

NZ_JAKVFF010000018.1 Lanthipeptides: MKR34_RS11425_lanthipeptideNZ_VDOJ01000018.1 Lanthipeptides: FSV48_RS11975_lanthipeptide

Lanthipeptides: HHJ99_RS13350_lanthipeptide

KKGSGVVPTVSHDCHMNSWQFLFTCCS

KK SGV+PTVSHDCHMNS+QF+FTCCS

KKKSGVIPTVSHDCHMNSFQFVFTCCS

81.5%

NZ_CP046304.1:

Lanthipeptides: FOC54_RS00030_lanthipeptide

KKGSGVVPTVSHDCHMNSWQFLFTCCS

KK SGV+PTVSHDCHMN++QF+FTCCS

KKKSGVIPTVSHDCHMNTFQFMFTCCS

with 73 more sequence matches

Only the first 10 are displayed here.

74.1%

NZ_CP069183.1:

Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

KKGSGVVPTVSHDCHMNSWQFLFTCCS

K GSGV+ T+SH+C+MNSWQF+FTCCS

KGGSGVIHTISHECNMNSWQFVFTCCS

70.4%

NC_012470.1and 11 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide

Lanthipeptides: SZO_RS04070_lanthipeptide

SGVVPTVSHDCHMNSWQFLFTCCS

+GV T+SH+CHMNSWQFLFTCCS

NGVFKTISHECHMNSWQFLFTCCS

70.4%

NZ_CP026729.1:

Lanthipeptides: BKKJ1_RS07010_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCC

G+GVV T+SH+C+MNSWQFLFTCC

GNGVVTTISHECNMNSWQFLFTCC

70.4%

NZ_GL882519.1:

Lanthipeptides: HMPREF9056_RS03330_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

G+GV T+SH+CHMNSWQF+FTCCS

GNGVYYTLSHECHMNSWQFIFTCCS

70.4%

NZ_JH792236.1and 1 other:

NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide

Lanthipeptides: IIM_RS26245_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

GSGV+ T+SH+CHMNSWQ +FTCCS

GSGVIKTISHECHMNSWQAIFTCCS

70.4%

NZ_VDNV01000006.1:

Lanthipeptides: FSV44_RS08765_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

G GV+ T+SH+C MNSWQFLFTCCS

GGGVIQTISHECRMNSWQFLFTCCS

66.7%

NC_012470.1and 2 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide

Lanthipeptides: SZO_RS04065_lanthipeptide

SGVVPTVSHDCHMNSWQFLFTCCS

+G + T+SH+CHMNSWQFLFTCCS

NGAIKTISHECHMNSWQFLFTCCS

66.7%

NZ_CP023483.1:

Lanthipeptides: CNY62_RS11970_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

G+G + T+SH+CHMN+WQFLFTCCS

GNGAIRTISHECHMNTWQFLFTCCS

66.7%

NZ_CP072384.1:

Lanthipeptides: J5A65_RS01395_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCC

G GVVPTV+H+CHMNSWQ+ F CC

GRGVVPTVTHECHMNSWQWFFGCC

66.7%

NZ_JAEEGA010000010.1:

Lanthipeptides: I6N95_RS15660_lanthipeptide

GSGVVPTVSHDCHMNSWQFLFTCCS

G+GV+ T+SH+CHMNSWQ++FTCCS

GNGVIKTISHECHMNSWQWIFTCCS

MIBiG 4.0 matches for BM262_RS05670

14.8%

BGC0000468.5 (CCM09443.1)and 2 others:

BGC0000469.6 (AFV25481.1) Bottromycin: bottromycin A2BGC0001157.6 (CBG72694.1) Bottromycin: bottromycin A2

Bottromycin: bottromycin A2

PTVSHDC

P V DC

PVVVFDC

14.8%

BGC0000470.6 (AFU90404.1):

Bottromycin: bottromycin D

PTVSHDC

P V DC

PAVVFDC

11.1%

BGC0002111.3 (EVG22_32245)and 1 other:

BGC0002111.3 (multiple genes) Lanthipeptide: andalusicin A or andalusicin B

Lanthipeptide: andalusicin A or andalusicin B

TVSHDC

T+S++C

TISNNC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

BM262_RS05610: PT_FPPS_like

Domain 1 (25 - 280): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.15 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.32 out of 28.19

Confidence: strong

Additional weak hits (6):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.27 out of 31.73

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.57 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 30.11

Confidence: weak

Lanthipeptides

Terpene

TFBS Finder

Core peptide predictions

BM262_RS05670 - Class II

Cleavage pHMM score: 5.40

RODEO score: 0

Monoisotopic mass: 2889.3 Da

Molecular weight: 2891.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2909.3 Da N = 1; 2927.3 Da N = 2; 2945.4 Da N = 3

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_FOLK01000003.1 - Region 1 - RiPP-like

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Location: 1 - 10,977 nt. (total: 10,977 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.45	ribosomal	coagulin	Bacillus coagulans
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000484.5	0.44	ribosomal	glycocin F	Lactobacillus plantarum
BGC0002586.2	0.44	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002579.2	0.43	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000500.5	0.42	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001407.5	0.41	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000494.5	0.40	ribosomal	uberolysin	Streptococcus uberis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.45	ribosomal	coagulin	Bacillus coagulans
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000484.5	0.44	ribosomal	glycocin F	Lactobacillus plantarum
BGC0002586.2	0.44	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002579.2	0.43	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000500.5	0.42	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001407.5	0.41	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000494.5	0.40	ribosomal	uberolysin	Streptococcus uberis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 26.79 out of 30.25

Confidence: strong

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.86 out of 26.85

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
RutR	Regulator of the pyrimidine and purine metabolism
ToxT	Regulator of MSHA biosynthesis

NZ_FOLK01000004.1 - Region 1 - arylpolyene

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Location: 44,790 - 86,982 nt. (total: 42,193 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BM262_RS07440: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: phosphotransferase

BM262_RS07565: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Ligases: synthase

BM262_RS07385: pseudouridine synthase

smcogs: SMCOG1279: pseudouridine synthase

BM262_RS07475: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001258.3	0.57	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.57	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.56	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.56	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002510.2	0.47	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0002404.2	0.46	other (other)	falcarindiol	Solanum lycopersicum
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001184.4	0.44	other (other)	bacilysin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001258.3	0.57	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.57	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.56	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.56	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002510.2	0.47	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0002404.2	0.46	other (other)	falcarindiol	Solanum lycopersicum
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001184.4	0.44	other (other)	bacilysin	Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.32 out of 32.93

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.11 out of 23.05

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.33 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

Additional weak hits (2):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.11 out of 36.54

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.43 out of 29.38

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

BM262_RS07435: pk

PKS_AT (65..199): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CcpA	Catabolite control protein A
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes