LOCUS       NZ_FOKG01000036        26500 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Amycolatopsis marina strain CGMCC 4.3568, whole genome shotgun
            sequence.
ACCESSION   NZ_FOKG01000036
VERSION     NZ_FOKG01000036.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis marina
  ORGANISM  Amycolatopsis marina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900111885.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:41:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,708
            CDSs (total)                      :: 6,643
            Genes (coding)                    :: 6,572
            CDSs (with protein)               :: 6,572
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2, 5 (16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 22 of 71
            Pseudo Genes (incomplete)         :: 62 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 15 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:06:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1819
            Orig. end                         :: 28319
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOKG01000036.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26500
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26500
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26500
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16500](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16500)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(153..167)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.58"
                     /tool="antismash"
     gene            complement(449..2491)
                     /locus_tag="BM199_RS31560"
                     /old_locus_tag="SAMN05216266_1365"
     CDS             complement(449..2491)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00937.1"
                     /locus_tag="BM199_RS31560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_1365"
                     /product="ABC transporter permease"
                     /protein_id="WP_091679546.1"
                     /transl_table=11
                     /translation="MSTVPGFLLDRVTVTRGPTRLLDGVCARLPAGACTAVVGPSGAGK
                     STLLRLLNRLEDPSTGQILLNGTPLTELDVLALRRRVGLVAQQPGAAHHHHQRSALLPA
                     IDSTKVVGLISLPGAMTGLILAGVDPLTAIRYQIWSCTCCSPPPPSPHSPPPDSPNTPC
                     STTPTASSHSPNPTNRAHPPPHLRGMRAGHGRRCAAVSDTPHSQLQPWLHSTVEKNEER
                     HPPSSEPASLDVIPLRTATWAWFLISLQTFGGPAGQIAVMQRTLVEEKRWIGHQRFLHA
                     LNYCMLLPGPEAQQLAIYVGWLLNGRRGGIIAGTLFVLPGMLALLALSAIYVAFGDTTL
                     VTAIFAGLAPAVVAIVAQAVARVGKRALHHPALVAIAAAGFIALAVFAVPFPIVIAAAA
                     AIGWALGRFAPSTIKPPPTNGAADGPAPLIADDTLHHEPPSARRGLTVLGVGLLLWAAP
                     IAAVAVFTGVGSTLTTQGLFFSGTAVVTFGGAYAVLAFVAQRAVEVYGWLSAQDMVRGL
                     ALAESTPGPLIMVVQFVAFLGAYHHPGGLDPWVAGVLGALLTTWVTFVPCFLFILLGAP
                     YVERLRHNRAISTALTGITAAVVGVIANLALYFALHTLFTTSEAHRFGPLQLNLPELAS
                     FRSVPAAITAIAFVLVFALRWPMLRTLAVCAGLGATAALLGLPLT"
     misc_feature    complement(1856..1858)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1934..1936)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2488..3885)
                     /locus_tag="BM199_RS31565"
                     /old_locus_tag="SAMN05216266_1366"
     CDS             complement(2488..3885)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="BM199_RS31565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_1366"
                     /product="ATP-binding protein"
                     /protein_id="WP_091679549.1"
                     /transl_table=11
                     /translation="MIRRWPIRIRLTAAFTVMMALVLCGVGIVTVTHTRESLDASISES
                     LEHRLRDLQPIATTAAPVLSSGGRDTGEQVLDDAGQIIASSPDVADQPLLTPAELATAR
                     RGELVVDHATAGQLDGPVRIAAAPTGADGRIAVAAVTLADRDAAVADLRQELAVGLPLA
                     LLAAAVGAYLLAAAALRPVERMRARAATITAAHPTQRLPVPSARDEISRLGTTFNDLLD
                     RLHAAVERERQFVADASHELRTPLSLLTTELELAARRPRTTRELTAALGSALEETERLS
                     RLAQDLLLLARTDQAGPPARPGEPTLVRPVLESVIARYRSTLDEHQVLLDCAPELTVRA
                     DPGDLDRAVSNLIDNAVRHGQPPVIITASPPDTELGVSIRVRDHGSGIAPEFLPHAFDR
                     FTRADDARTGGGTGLGLALVAALARRNGGAATAANHPDGGTTVILTLPAANRPDATVPD
                     APAAATG"
     gene            complement(3882..4586)
                     /locus_tag="BM199_RS31570"
                     /old_locus_tag="SAMN05216266_1367"
     CDS             complement(3882..4586)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673047.1"
                     /locus_tag="BM199_RS31570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_1367"
                     /product="response regulator transcription factor"
                     /protein_id="WP_199542961.1"
                     /transl_table=11
                     /translation="MRVLVVEDEPKMAGLLRRGLVEEGYAVDVAADGADGFGAAVSRDY
                     DAVVLDVMLPRLSGFEVCRRLRRQQVWVPVLMLTARDAVTDRISGLDGGADDYLTKPFH
                     LAELFARLRALTRRGPVARPTVLAARDLRIDPASRRCWRGETEIAVTAKEYALLEMFLR
                     QPGVVLTRELLLEHCWDFAYESRSNVVEVHIRALRDKIDRPFAVVSLETVRGAGYRLRP
                     DGGRPRVEVGAR"
     misc_feature    4713..4726
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            4775..5107
                     /locus_tag="BM199_RS31575"
                     /old_locus_tag="SAMN05216266_1368"
     CDS             4775..5107
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS31575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_1368"
                     /product="hypothetical protein"
                     /protein_id="WP_091679554.1"
                     /transl_table=11
                     /translation="MNRKTKIGIGIAAGVLVLTGGGVGLASAMSGDGDEVSGPAADQAR
                     AAAVQTVAGGKAGAVETETDEGAAAYGVTVTKPDGSTVEVHLDSTFHVVGTEAPGQDHD
                     ADGDEG"
     gene            5167..6141
                     /locus_tag="BM199_RS31580"
                     /old_locus_tag="SAMN05216266_1369"
     CDS             5167..6141
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030378.1"
                     /locus_tag="BM199_RS31580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_1369"
                     /product="DUF1259 domain-containing protein"
                     /protein_id="WP_083666521.1"
                     /transl_table=11
                     /translation="MPFTPARAARVVLPLAALLLVPLAGCGTDTTPASDTAADAEHRRH
                     QPIPTTEADWKPVTDTLGRTGKFGDNNTVYRIGLPRTDLQVTSGGVEIKPGLSLGGYAA
                     FAKYRDGVMLMGDLVVTEAELPKVTDALQAHGIAQTALHKHLLQQTPPVWWTHIHAMSD
                     DPAALAQGVQAALDATAIPAPAPPGQQPPIDLDTAGIDQALGRKGTADGGIYKFSIARK
                     ETITDDGHVLPPTFGVTTAINFQPLGGGRAAINGDFVMTAPEVQKVIQALRTGGIDLVE
                     VHNHSLTEQPRLFYMHFWAVDDGVTLAKALRPALDATNLQPPG"
     gene            6240..6452
                     /locus_tag="BM199_RS31585"
                     /old_locus_tag="SAMN05216266_13610"
     CDS             6240..6452
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015996.4"
                     /locus_tag="BM199_RS31585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13610"
                     /product="DUF378 domain-containing protein"
                     /protein_id="WP_091679556.1"
                     /transl_table=11
                     /translation="MRPRTVLDWIAFVLLLIGAFAWAAFVTDINVLDRALEPIADPLDD
                     IVFVLIGLAGLYWIGRVVVGDRTHQ"
     gene            6449..6994
                     /locus_tag="BM199_RS31590"
                     /old_locus_tag="SAMN05216266_13611"
     CDS             6449..6994
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030379.1"
                     /locus_tag="BM199_RS31590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13611"
                     /product="Chromate resistance protein ChrB"
                     /protein_id="WP_245788976.1"
                     /transl_table=11
                     /translation="MSNSTDPAHERPSTGSAAPRQAGQRAGQWVLLSYRMPREPSTPRI
                     TVWRKLKRLGVAQLGDGLVALPADARTREHLDWIADEILAAGGTAGVWLAQPTSLAQER
                     RLAQTMAAARAAEYRAVLTEAEQARSLGEAERRRALRTLRAELRRIHRRDYFPPPERDT
                     AQAAVDALHPDHHTEETA"
     gene            6991..7423
                     /locus_tag="BM199_RS31595"
                     /old_locus_tag="SAMN05216266_13612"
                     /pseudo=""
     CDS             6991..7423
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021357.4"
                     /locus_tag="BM199_RS31595"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13612"
                     /product="chromate resistance protein ChrB
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKWATREHIHIDRAACAWLIRRCIDPDAAFVFVTDPADVPPRRHP
                     VRHARRRPRPPRRRLQLRNHPAPPRPHRPRALAHRRNHPRSRPRRRTLRRPRSPRPRRH
                     PPRPIHDRRRPAHPHHHQTHLRRPLRVLPPRPDARPRTRM"
     gene            7420..8025
                     /locus_tag="BM199_RS31600"
                     /old_locus_tag="SAMN05216266_13613"
     CDS             7420..8025
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016149.4"
                     /locus_tag="BM199_RS31600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13613"
                     /product="copper resistance CopC family protein"
                     /protein_id="WP_075849313.1"
                     /transl_table=11
                     /translation="MTAGNIRRATLGILAALLCASLLGTDHPATATPSSAVPLLEEATP
                     PANAVLTEPVDWVYLTFDRLINTFSIRVTGPNGHDVARDNAIVKHDMISQPLHTLTQPG
                     TYRVTWQVIDLDGHQASGSHSFTITPGVTTTPENTATTPATTPHSVPPTAPPATNQSTI
                     TTPLAATIALSLLAGLTLLTIRHRRRVRASRAQRPDRT"
     gene            complement(8160..8753)
                     /locus_tag="BM199_RS31605"
                     /old_locus_tag="SAMN05216266_13614"
     CDS             complement(8160..8753)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.4"
                     /locus_tag="BM199_RS31605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13614"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_083666522.1"
                     /sec_met_domain="PCMT (E-value: 4.2e-40, bitscore: 128.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTTTTSPEALRAAMVERIQKAGHAKHSDVERVLRDTPRHEFVPD
                     ADLAVAYDPWQAVVTHRFEDGRSLSCASAPWLVAAMLDQLDVQPGNRILEIGVGTGYNA
                     SLLAQLTGRADLVTTIDVDPDVTAKASQALAAAGYGDVHVITGDGGLGYPDHAPYDRMI
                     ATVSPWDIPAQWWKQLAPGERLVAPLRFPVKSAC"
     gene            complement(8871..9995)
                     /locus_tag="BM199_RS31610"
                     /old_locus_tag="SAMN05216266_13615"
     CDS             complement(8871..9995)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151818.1"
                     /locus_tag="BM199_RS31610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13615"
                     /product="hypothetical protein"
                     /protein_id="WP_075849513.1"
                     /transl_table=11
                     /translation="MDPAGQFARRFPLVARTRPACLPLARRVAELCDRARQVEHSGELA
                     EAAAVHNNAALIASDCGLPELARRWCHQQVNIYLRARPLGAQVARLALEPITNLARLYI
                     REGQGERAFALIDTLFTAVSARTDAIVDGIEIPADLTDSAETHQHIRSWLWAVLLATGG
                     RALAAAGRWAEARARLDAYKGVGRRMLDGRQIAVIAHAVSGDTDSALTLLADTTPGDPW
                     ENAVTACLTIQCHGASGVADLPTLLNQYHRLDTSAPGLAVFHTRLGLSFIDAIGTVDDP
                     PVHQIAVDLIDYAAATRDGYVARDVLAHNGCRELLTDSQARELSDSVEACALGSGTLPA
                     TLLADLTTALACAEEAMARSVKTMSCNVNAPANP"
     gene            complement(10001..12094)
                     /gene="fxlM"
                     /locus_tag="BM199_RS31615"
                     /old_locus_tag="SAMN05216266_13616"
     CDS             complement(10001..12094)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="BM199_RS31615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13616"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_091679559.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2e-35, bitscore:
                     113.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 2.1e-46, bitscore: 149.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPDSWHHYLVEFADPTTAEHTAATLLVPALDQAQQDGELDTWWH
                     LRKTPAWRLRYQPVNPETKAVDTLLSDLEADGHLARWTRGIYEPETLAFGGPAAMDIAH
                     SLFHHDSRHCLARATKPAALGQRETTVLLFSSMLRAAGLDWFEQGDVWDKVAALRPTAQ
                     PHSNNSPHTERLSQAVRRLMTTNTHKVADVAPDVVPETWWTAFDTAGRQLAELARAGHL
                     ERGLRAVLAHHFIFHANRAGLSGTDQATLAALAVDTVFYSTPTRQAPAGTTSNTVRVPA
                     MTTTVSDASTGSADELRTKLADRLVKDGTVRTDAVEAAFRQVPRHLFLPDVPLVEAYAD
                     EPVYTKHEGDGTRISAASQPKIVAMMLEQLGIQPGERLLELGAATGYNAALMATLTGAD
                     GHVTTIDIDEDLVAGAREHLAAASIDNVEAVAADGALGHPETAPFDRVIATVGAHEVPA
                     AWLDQLTPGGRLVAPVRLRGCASRSIVFERDQDGWRSLGSEMAIFMPLRGLGDDARRVL
                     DLTGTGEVTLQIHKDNNHATDPDTLTGVFDSPACEVWTGVHFVPMESFEWLDLWLACHL
                     PNPLMRMEVAPAAKESGLVRPMFPSVAMATTAADGSLAYLTIRAADPDPDGGRRYEVGV
                     IGHGPNAQELAEQVSVEISTWDQGFRASTVRFAIPDTAPQPDTNPGFVVLDRPTKPMTV
                     TWE"
     gene            complement(12140..13390)
                     /locus_tag="BM199_RS31620"
                     /old_locus_tag="SAMN05216266_13617"
     CDS             complement(12140..13390)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151816.1"
                     /locus_tag="BM199_RS31620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13617"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_091679561.1"
                     /sec_met_domain="LANC_like (E-value: 4.3e-46, bitscore:
                     148.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNADLASDAAVEYATGIADRLARPDAPHLPTDEPWWHQSLAHGAP
                     GVALLHIELAAAGIRPFDRAHDWLTAVTSKPITAGASTGLFYGAPAVARALAGAATVRP
                     GTYQSALTPLTRQIAADAHNRVDKAHERMDVVGMLPQMAEFDTIRGLAGLGAHLLHHDP
                     DGTALPAVLGALVRLTQPVMVEGEALPGWWTLTGPTGHEDDEFPGGHGNFGVAHGIGGP
                     LALLAQALRRGIAVDGQRQAVATICAWLDSWRISTPSGHRWPYMVTRDEARSTPMYVRH
                     SGASRRPSWCYGTAGIARTLHLAALALDDADRRQIAEEAVISAVTDPEQDALISDASLC
                     HGYAGLARITAHTAIDTPEPAASRLRALATEMLHRACAQAVPEGPGFLEGAAGVGLAAL
                     AAEIEPATGWGTGLLIT"
     gene            complement(13387..16500)
                     /locus_tag="BM199_RS31625"
                     /old_locus_tag="SAMN05216266_13618"
     CDS             complement(13387..16500)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151815.1"
                     /locus_tag="BM199_RS31625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13618"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_177242877.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6e-203, bitscore:
                     666.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.9e-20,
                     bitscore: 63.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-21, bitscore:
                     68.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTALPDRVGFRAAGGLLVRAVAEGELKLPPWPTLTATGADAVTA
                     WVDWLREVWEVEAVRDAIGLASPVLADRVHNLCGAQVASERESRRVVLSVLRYLARLTG
                     RPTPNGLFAGVTAARFDADPSQRWGDDHRADAAADAGWLAEVIRRLEGQAEILERLVLV
                     ANSTLMVRGERLVVPYQPTVNHRGTGAVEVELRYTGPVRAAVRAARTPIPFDDMREQVQ
                     AEFPSTAGSTVTGLLATLVARRVLVTNLHAPSTEPDALGHLVRELATVGEAATERCMTL
                     NDIHDMLRRHRNSPAEARRRLRTDAAASMSRLAPSRRSPVTVDLRLDLDVVLPSAVARE
                     AERAALVLARLTSRASSTAAWADFHRRFYQRFGTGAQVPLLEVIADSGIGWPDGYPGTS
                     GVVTRPQQTPRDERLLALAQAAALDGQQEVVLGERLIAELELAPVHSMRLPSHLELCAR
                     VDSPSLQALKQGNFQLVVTSVSRSAGVVSGRFLHLFDEHDRRMLITPLAPPASDGVIQA
                     QLSFPPLDPATAHVARSAQVLPTIVSLAEHRDTAASTAVLTAADLAVSCDSDRLYLTAP
                     ALGARVEAWGLHALNLRKHTPPLARLLVELTRAHCAEVTDFDWGTAATLPFLPRLRFGR
                     IVLSPARWRLAAADLPDRTSSWATWDSALAEWRTRRRLPQAVFLVDGDWRLPLDLVEDA
                     HRVLLREHLGTHPHAVLEEGPAEDAAGWLDGRAHDVVVPMASCQPQATTRPPRPTPQRI
                     VRPGEHGLSPGGSPMLFAKLYGDPQRHNTVLAKHLPALLAEWGDAQPRWWFLRFREGNE
                     HYLRLRISLLSTEPVVFGEAAGRVSAWADRLRRLGLLRDIAFATSYPETGRWGSGAALS
                     AVEAFFTADSRAVLAELAWPARPHDHALAAANFAAIAVAFMGGTEAGMRWLVDHVPAKP
                     PTVVPRPVFTEAQCLADPSENFRALRSTPGAASVVATWAERAQTVAAYRAHLSGAEAEG
                     VDPDAALGSLLHTHFLRAYGIEPDDKAVCLYLARTAALTFAARTGGPR"
     aSDomain        complement(15742..16017)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BM199_RS31625_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.30E-20"
                     /identifier="RREFam001.1"
                     /label="BM199_RS31625"
                     /locus_tag="BM199_RS31625"
                     /protein_end="253"
                     /protein_start="161"
                     /score="63.6"
                     /tool="antismash"
                     /translation="LVANSTLMVRGERLVVPYQPTVNHRGTGAVEVELRYTGPVRAAVR
                     AARTPIPFDDMREQVQAEFPSTAGSTVTGLLATLVARRVLVTNLHAP"
     gene            complement(16582..16767)
                     /locus_tag="BM199_RS31630"
                     /old_locus_tag="SAMN05216266_13619"
     CDS             complement(16582..16767)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151814.1"
                     /locus_tag="BM199_RS31630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13619"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_009151814.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2e-17, bitscore:
                     54.0, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQMEWSPTTVATPAAEVEMGSEFDLDITLVEVVDPAHLINMTD
                     DGCGTTCEKSTCISAA"
     CDS_motif       complement(16654..16767)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTVQMEWSPTTVATPAAEVEMGSEFDLDITLVEVVDPA"
                     /locus_tag="BM199_RS31630_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16582..16653)
                     /prepeptide="core"
                     /locus_tag="BM199_RS31630_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="1.70"
                     /molecular_weight="2263.5"
                     /monoisotopic_mass="2262.0"
                     /core_sequence="HLINMTDDGCGTTCEKSTCISAA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTVQMEWSPTTVATPAAEVEMGSEFDLDITLVEVVDPA"
                     /leader_location="[16653:16767](-)"
                     /alternative_weights="2281.5"
                     /alternative_weights="2299.6"
                     /alternative_weights="2317.6"
     gene            17218..18501
                     /locus_tag="BM199_RS31635"
                     /old_locus_tag="SAMN05216266_13620"
     CDS             17218..18501
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151813.1"
                     /locus_tag="BM199_RS31635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13620"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_091679590.1"
                     /transl_table=11
                     /translation="MSDRRDAFAARREQMGYTQESFGAAVGVEFSTVGRWERGTLTPQP
                     YRRPCLAKTLDVSLDQLDALLTPNRQASTIATEPADPAEADDMNRRDLLRLFSMTGALL
                     ALPAGETVLGDVDRLAATAHAGTVDTAGAAEFAQLNSHLWRVYALSPTKAQVLPLVRAQ
                     LGVLSDSLRRPQTPTIRQRLCELTADLFQLAGEIFFDGNRYTDAAHCYTLAATASKEAV
                     ASDLWACALTRHAFVAVYERRFADAAPMLDVAATIARRGDPSLSTRHWVAVVQAETFAG
                     LGDFDSCQHALDTAAEVQRLRGQVHNGGWLRFDGSRLAEERGTCYVTLGRHDLAEAALV
                     DALQGTLTARRKAGVLTDLAMIGVHRRDPDQVVTYADTVLTTARQTRSGVIAQKLRVLQ
                     PHLASLLNDQQIQRLDAEITKLVGNRAA"
     gene            18516..18875
                     /locus_tag="BM199_RS31640"
                     /old_locus_tag="SAMN05216266_13621"
     CDS             18516..18875
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151812.1"
                     /locus_tag="BM199_RS31640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13621"
                     /product="hypothetical protein"
                     /protein_id="WP_073575400.1"
                     /transl_table=11
                     /translation="MHNDRGRVFREAWIAGVTKHYPGEPKPGYITPWDQTPDWERDAAT
                     AVYDQVVAFIKATDGATTKLTPDQKGRFVALCWIGQIFKHFPEPKPSYVADWNDLPDWQ
                     KATDIDIFERIERDA"
     gene            18868..19080
                     /locus_tag="BM199_RS31645"
                     /old_locus_tag="SAMN05216266_13622"
     CDS             18868..19080
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS31645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_13622"
                     /product="hypothetical protein"
                     /protein_id="WP_199542942.1"
                     /transl_table=11
                     /translation="MPDQATIDAAAVDARLAETEYDDAQAWLHARSTALEPLAAEVWVT
                     DPEHRHVLLVRHRVRGWVPPVMASI"
     gene            19180..20634
                     /locus_tag="BM199_RS31650"
                     /old_locus_tag="SAMN05216266_13623"
     CDS             19180..20634
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151810.1"
                     /locus_tag="BM199_RS31650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13623"
                     /product="site-specific integrase"
                     /protein_id="WP_091679564.1"
                     /transl_table=11
                     /translation="MDHFFVSRDKVRRYFEPVPGLGVDGLTVLRRKGSPQDGTPFFLGR
                     DMRPVEPLCSFMFEMAKTHQPKTLSDYTYDLLDLVDFLAQLEPSTDVLSATEENLIAYR
                     AERTELQDKPNAPATWKRRRALINNFYEWAVEAQWLDRKPYRRLRNGRDVLAWGAVSDL
                     DIRHLTHRQWRFLKQVGLRGMLPADRVDLSFRGSAPLRNAAAAELAVTTGMRLREFTSL
                     LDIEVGLPRRDCLPVDVRLEMIAKYSLPRDVTIQHSVMKELDLYRRTERAATIRRAAPA
                     LTRRRAELFVVTDIDERQMKVSGRLHGRRRTFSIEKMTAELRRIAVTEGPCGLEPMALF
                     VGRGGRMLSKQRWEQIFDDAHARSLRIAAENGVDMVMPRRFRIHDLRHTFSVYMLEQLT
                     QLVIAQETDRRLNGGHNAYLADHICRNPQLILQRLLGHLNPGSTMKYLRYVRNTNVLVA
                     QAIAEWNESDKTYAEYAALAAERAVL"
     gene            20688..22619
                     /locus_tag="BM199_RS31655"
                     /old_locus_tag="SAMN05216266_13624"
     CDS             20688..22619
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS31655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_13624"
                     /product="hypothetical protein"
                     /protein_id="WP_143101984.1"
                     /transl_table=11
                     /translation="MKPANSDRIGDRVIVRERRGRTVRLSIAPSLFRCSVLVAELADEA
                     VAYAHRVSLRKPDCYFTAVRELGTFLDEHLPTVGCEPAEARLAGMKIDLIEALFCWEAD
                     LRRRHGLRSAEPYRKAAAVLALIDMRAERDPNVPETLRRRAAGPPTYKRRPNAVLDEYS
                     NEERLALQEAARADVRALEKRLTRGQHLLRSGADPRREGWHDLANLVWAAKHRLLTTTD
                     LLEHLPMNSSSWSQPIKDVIEANPPGRERGVYACLKAINRLLFPSEQDLQPFRVLLLLG
                     MADCTPEELLDLRMADLEFSDAGVRVRQTKLRANRIRADFHPDLPDSKASTGDVADLDG
                     DTGSEVYLAVGRWDVGGLLRRLMEVTWQARESFDSEDVLFLAVEAGRPRTTMRARVATW
                     TEDHNGFSAWISWHRNDDGTPAMAISQPHYARRLRKTVKTARVAALGGTLTDVAADDHH
                     IEVFRHHYAHGTTALTLAGRSINRAQERVFHTITTKPMLLDTQAEHRLAEPEVAEAAGM
                     TVEHAAAMRAGEYDMGLTHCRDPYDSPFTPGGKPCHVAPAMCMICRNAVVFISQLPRLL
                     LLAAHIERMRDALDPIRWTAIWGTQATALAEVFAECTAQQLHDAHEAIGDQGLRLDLPL
                     GMRTEYDR"
     gene            22616..25087
                     /locus_tag="BM199_RS31660"
                     /old_locus_tag="SAMN05216266_13625"
     CDS             22616..25087
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS31660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_13625"
                     /product="hypothetical protein"
                     /protein_id="WP_091679569.1"
                     /transl_table=11
                     /translation="MSTTPQPTAVTSTLVSADEAVFGSGHPLVEGVPIPEFGESRSWSF
                     GCIRRPSNVRPAAWKVNFTVIDSVWNLRIREICFSMLNPTHKVIRDAGIALVAEPAAHS
                     TVRQCAYTLGKLAAWALANDMPADIAAWREEDWAGFVEHITARANALKPDATALSWLST
                     LAPVLTHGGMAQGLWNTDTFREIRHRSDTPSTASIPPSTWWPLLRAAWAYIHEFSPHIL
                     DLRDQLAQQPDPGDSPERRPAFRTPAGNDELVDNWLANPDNLVPVHKYDHQTKSAGEPI
                     WHHLALTITGGTNTGLFQTTRKGAAQRRRDAVLRAVERGQVQAYSWSEMRARTDVVNHP
                     AIYLGRSTAALDQVLDDWLTNPDNLIPIRTKQPRAPRSDLEPGTIIWTALEALIYGTAG
                     TAPFTQRSVTSAARRQKVEDAAAAGRVQKLAGTMTTRSLPMPCKDFTSVTRQDGTTRPW
                     RGQISVEELADEIRMVRAACYVFMAGLTMMRDSEIQEIERGSLTAYYGAPAVKSRKLKH
                     DPAQPELNWWISAPVVETLAVLDRLSWHHTHLFVALDPPRVTAHNEDTVRGIDAAGEID
                     FFVAGVNASLERTGLEEIPAGRIRPHMFRRTMSIICSQEPDSEIALGHQLKHLARRTLA
                     NRITQGYSRMDTHWAKEFDNQLELAAAGRLVELLKSRRSGTDVAVGPAAAKLHSGLDNV
                     IATMNRAPALRAQLADEQIEVLLLRDEFADLHFGTVNHCLWDPAQAECQNSLPEGQRGK
                     TPVLGACQPARCRNSAVDQDKHGPVWLAEDADLTRMLRDPRLATPRRAALENRLSEVRL
                     ITGTWLTKERP"
     misc_feature    24767..24769
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            25087..25554
                     /locus_tag="BM199_RS31665"
                     /old_locus_tag="SAMN05216266_13626"
     CDS             25087..25554
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151807.1"
                     /locus_tag="BM199_RS31665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_13626"
                     /product="hypothetical protein"
                     /protein_id="WP_091679571.1"
                     /transl_table=11
                     /translation="MAVSPPTETKLRAAIQRLLDGVPIHTDGALTKENLAREAGVSHAT
                     VHRAGEILAEWDTRVARPVLRSTGEVRRAEKIEALTAALRAEKRAVTELQGKLDALASV
                     TADLYHENLTLRKRLDKQPPVTSMDTRAARSESSPVRGIERARGHRQTRPL"
     gene            25564..26079
                     /locus_tag="BM199_RS31670"
     CDS             25564..26079
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151806.1"
                     /locus_tag="BM199_RS31670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX hydrolase"
                     /protein_id="WP_091679574.1"
                     /transl_table=11
                     /translation="MTPHAPGPDTLHAAIVDAGLAEFEFDDARMWLKNACHGPMAPFAA
                     DVWAFDSTFQHILLVRHRWRGWVVPGGMVERGETPRQAARRELEEETGMAADLLELPAA
                     VTVRSYRSDWTPTLGLTYAAVVDPSLPLNGERHQSAAWNPLAQDWTGAFPEDITRIRRY
                     AQAGASAQ"
     misc_feature    25996..25998
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gatcgtcgct ctcgcccagg aggccggtgt tccccgcaac gcgctcaccc aacgtcacac
       61 cgatctcagg gccgagttct acacgcgggt ccgcgagaac ggcggcccct ccgaggttga
      121 agaccggctg cgccagacca tcgtccggct caagaacacg atcgccaaca agaacaccga
      181 gcttgagcag ttccgcgagg acgtgtcctc gctggttcgc gccatcaacg tgctcacact
      241 ggaaaaccag cagcttcgtg aggccaacac gcaggacgag ccggccgttg taccgctccg
      301 gccccgacgc ccaaccacga cgggataggt gacgcactga aacgcaagcc acggccggcg
      361 cggcttgcga cgtgacaaca gctggtccgg ccgtcgtaga cccgtacgct gcgggcgctt
      421 cgacgatcga tgggcatgtg ggctcgattc aggtgagggg aagcccgagc agtgcggcgg
      481 tggcgccgag gccggcgcag acggccaggg tgcgcagcat cggccagcgg agcgcgaaca
      541 ccaggacgaa ggcgatcgcg gtgatcgcgg cgggcacgga acggaagctg gcaagttcgg
      601 gcaggttcag ctgtagcggg ccgaatcggt gggcctcgct ggtggtgaag agggtgtgga
      661 gggcgaagta gagggcgagg ttggcgatca ctccgacgac agcggcggtg atgccggtca
      721 gcgcggtgga gatggcgcgg ttgtggcgga ggcgttcgac gtagggggcg ccgagcagga
      781 tgaacaggaa gcagggcacg aaggtgaccc aggtggtcag cagcgccccg agcaccccgg
      841 ccacccatgg gtcgaggcca ccggggtggt ggtaggcgcc gaggaaggcc acgaactgca
      901 cgaccatgat cagcgggccg ggggtggact cggcgagcgc gagtccgcgc accatgtctt
      961 gggcggagag ccagccgtag acctcgaccg cgcgctgggc gacgaaagcg agcacggcgt
     1021 aggcgccgcc gaaggtgacc acggcggtgc cggagaagaa cagcccctgc gtggtgagcg
     1081 tgctgcccac gccggtgaac accgccacgg cggcgatcgg ggcggcccag agcagcagac
     1141 cgacaccgag cacggtcagg ccgcgccgcg ccgagggcgg ttcgtggtgc aaggtgtcat
     1201 cggcgatcaa cggtgctggt ccgtcggcgg cgccgttggt gggcgggggt ttgatcgtgc
     1261 tgggcgcgaa ccggccaagt gcccagccga tggccgctgc ggcggcgatg acgatcggga
     1321 atgggaccgc gaacaccgcc agcgcgatga acccggcggc ggcgatcgcc acgagcgccg
     1381 ggtggtgcag ggcgcgtttg ccgacacggg cgacggcttg agcgacgatc gcgaccacgg
     1441 cgggggcgag cccggcgaag atcgcggtca ccagagtggt gtcgccgaac gcgacgtaga
     1501 tggccgatag ggcgagcagg gcgagcatgc cgggcaggac gaatagggtg ccggcgatga
     1561 tcccgccgcg gcggccgttg agcagccatc ccacatagat cgccagttgt tgggcctccg
     1621 ggccgggtag cagcatgcag tagttcagtg cgtgcaggaa gcgttggtgg ccgatccagc
     1681 gtttctcctc gaccagggtg cgttgcatga cggcgatctg gccggcgggg ccgccgaagg
     1741 tctgcagcga gatcagaaac cacgcccagg tcgcggtacg cagtgggatc acgtccaggc
     1801 tcgcaggctc cgacgatggt gggtgtcgtt cctcgttctt ctccaccgtg ctatgtaacc
     1861 acggttgcaa ttggctgtgg ggagtgtcac tcaccgccgc acacctacgg ccgtgacctg
     1921 ctcgcattcc acgtaagtgc ggcggtgggt gtgctcggtt agtggggttc ggggagtgag
     1981 atgaggcggt gggcgtggtc gaacagggcg tgttcggcga gtcgggcggt ggtgagtgcg
     2041 gcgagggcgg tggcggcgag cagcatgtac atgaccagat ctggtagcgg atggcggtga
     2101 gcgggtcgac gccggcgagg atgagtccgg tcatagcgcc gggcaggctg atcaggccga
     2161 cgaccttggt ggagtcgatc gcgggcagca gcgcggagcg ttggtggtgg tggtgagcag
     2221 caccgggctg ttgcgcgacc aggccgaccc ggcgccgcag tgccagcaca tcgagctcgg
     2281 tgagcggggt gccgttgagc aggatctggc cggtgctggg gtcctccagc cggttgagca
     2341 ggcgcagcag ggtggacttg ccggcgccgc tgggaccgac caccgccgtg cacgctccgg
     2401 ccgggagacg ggcgcagact ccgtcgagca gtcgggttgg gccgcgggtc accgtgaccc
     2461 ggtccagcag aaaaccgggc acggtgctca tccggttgcg gcggccgggg cgtccggaac
     2521 ggtggcgtcg ggacggttgg cggcggggag ggtgaggatg acggtggtgc cgccgtcggg
     2581 atggttggcg gcagtcgcgg caccgccgtt gcggcgggcc agcgcggcga ccagggccag
     2641 gcccagtccg gtgccgccgc cggtgcgggc gtcgtcggcg cgggtgaagc ggtcgaacgc
     2701 gtgcggcagg aactcggggg cgatgccgga gccgtggtca cgcacccgga tgctcacccc
     2761 aagctcggtg tcgggcgggc tggccgtgat gatgacgggt ggctgcccgt gccggacggc
     2821 gttgtcgatc aggttgctca ccgcccggtc gagatcgccg ggatcggcgc gcaccgtgag
     2881 ctccggtgcg cagtccagga gcacttggtg ctcgtcgagg gtgctgcggt agcgggcgat
     2941 cactgactcc agcacgggcc gcaccagggt gggctcgccg ggccgggccg gcggaccggc
     3001 ctggtcggtg cgggcgagca ggaggaggtc ctgggccagg cgggacagtc gttcggtttc
     3061 ctccaatgcc gagcccagcg cggcggtcag ttcccgtgtg gtgcggggtc ggcgcgccgc
     3121 gagttcgagt tcggtggtca gcaggctgag cggggtgcgg agctcgtggc tggcgtcggc
     3181 gacgaactgc cgttcccgct cgacagcggc gtgcaggcgg tcgagcagat cgttgaacgt
     3241 ggtgcccagc cgggagattt cgtcgcgagc cgacggcacg ggtagacgct gcgtggggtg
     3301 tgcggcggtg atggtggcgg cgcgggcgcg catccgttcc accgggcgca gtgcggcggc
     3361 ggccagcagg taggccccga ccgcggcggc gagcagcgcc agcggcaggc cgaccgccag
     3421 ttcttggcgt aggtcggcca ccgcggcgtc gcggtcggcg agggtcaccg cggccacggc
     3481 gatccggccg tccgcaccgg tgggggcggc ggcgatacgc accggcccgt ccagctgtcc
     3541 ggcggtggcg tgatcgacca cgagctcgcc gcgccgcgcg gtcgccagct ccgctggagt
     3601 cagcaggggc tggtcggcca cgtccgggga gctggcgatg atctggcctg cgtcgtcgag
     3661 gacctgctcg ccggtgtccc ggccgccgct ggacagcact ggtgcggcgg tggtggcgat
     3721 cggttggagg tcgcgcagcc ggtgctccaa cgattcgctg atcgaggcgt cgagcgattc
     3781 gcgggtgtgc gtcacggtca cgatcccgac cccacacagc accagcgcca tcatcaccgt
     3841 gaacgcggcg gtgagccgga tccggatcgg ccaccgccgg atcatcgcgc ccccacctcg
     3901 acccgtggtc gcccgccatc cgggcggagc cggtacccgg cgccgcgcac ggtctccagc
     3961 gagaccaccg cgaacggccg gtcgatcttg tcccgcagcg cgcggatgtg cacctcgacg
     4021 acgttggagc gcgactcgta ggcgaagtcc cagcagtgct ccagcagcag ctcgcgggtg
     4081 agcaccacgc cgggctggcg cagaaacatc tccagcagcg cgtactcctt ggccgtcacc
     4141 gcgatctcgg tctcgccgcg ccagcaccgc cggctggccg ggtcgatccg cagatccctc
     4201 gccgccagca cggtggggcg ggcgaccggg ccgcggcggg tcaacgcccg caaccgagca
     4261 aacagctccg ccaggtgaaa cggcttggtc agatagtcgt ccgcgccgcc gtccaggccg
     4321 ctgatccgat cggtcaccgc gtcacgggca gtgagcatca gcaccggcac ccacacctgc
     4381 tggcggcgca gtcgccggca cacctcaaac cccgacagcc ggggcagcat cacgtccagc
     4441 accaccgcgt cgtagtcgcg gctgaccgcc gccccgaacc cgtcggcccc gtccgcggcg
     4501 acatccacgg cgtagccctc ctcgaccagg ccacggcgca gcaggcccgc catcttcggc
     4561 tcgtcctcca ccaccagtac ccgcaccatc catcacctct cttcaggcgc cacccccgag
     4621 caccctgcac aggcgcccct tcacgggcac ggtgccacca catccgggtg accgccgtcg
     4681 tgtcttcatc acggcttcat ctccaccgac tacccatacc catgcaacca cctcatgcaa
     4741 ccacggttac aggagcgtgg agaatggaga aggcatgaac cgcaagacga agatcgggat
     4801 cgggatcgcc gccggagtgc tcgtcctcac tggtgggggc gtgggcctgg cctccgcgat
     4861 gtccggcgac ggcgacgagg tcagcggccc cgcggccgac caggcacgag ccgcggccgt
     4921 gcagacggtg gccggcggga aggccggcgc tgtcgagacc gagaccgacg agggtgccgc
     4981 cgcctacggc gtcaccgtca ccaagcccga cggctccacc gtcgaggtcc acctcgacag
     5041 caccttccac gtcgtgggca ccgaggctcc cggccaggac cacgacgccg acggtgacga
     5101 gggctgaccg cgtaccaccg accacgatct acaccgacca cgatcgagtt cgaggagggc
     5161 aaggacatgc cgttcacccc cgcccgcgcg gcccgcgtgg tgttgccgct ggccgcgctg
     5221 ctgctggtcc cgctcgccgg ctgtggcacc gacaccaccc ccgccagcga caccgctgcc
     5281 gacgccgagc atcggcgcca ccagccgatc cccaccaccg aggcggactg gaagccggtc
     5341 accgacaccc tgggccgcac cgggaagttc ggcgacaaca acaccgtcta ccgcatcggc
     5401 ctgccccgca ccgacctgca ggtcacctcc ggcggcgtcg agatcaaacc agggctgtcg
     5461 ctgggcggct acgccgcctt cgcgaagtac cgcgacggcg tcatgctcat gggcgacctg
     5521 gtggtcaccg aggccgaact gcccaaggtc accgacgcac tccaagccca cggcatcgcg
     5581 cagaccgcgc tgcacaaaca cctgctgcag caaacaccgc cggtgtggtg gacccacatc
     5641 cacgccatga gcgacgaccc cgcagcgctc gcccaaggcg tgcaagccgc actggacgcc
     5701 accgccatcc cagccccggc gccaccaggt cagcagccgc cgatcgacct ggacaccgcc
     5761 ggcatcgacc aggccctggg ccgcaagggc accgccgacg gcggcatcta caagttcagc
     5821 atcgcccgca aggagaccat caccgacgac gggcatgtcc ttccgcccac gttcggggtg
     5881 accaccgcga tcaacttcca gccactcggc ggcgggcggg ccgcgatcaa cggtgacttc
     5941 gtgatgaccg cacccgaggt ccagaaggtg atccaggcgc tgcgtacagg cgggatcgac
     6001 ctggtcgaag tgcacaacca cagcctcacc gagcaacccc gcctgttcta catgcacttc
     6061 tgggccgtcg acgacggcgt caccctcgcc aaagccctcc gccccgcgct ggacgccacc
     6121 aacctgcaac ccccaggctg ataccactca cgccgacagc gtttccggcc ccgtcgtgac
     6181 gatcggcggg gccggacaag caccatgaca acgagcatga caacgggaag gagcgcagga
     6241 tgcggccacg caccgttttg gactggatcg ctttcgtgct actgctgatc ggcgcgttcg
     6301 cctgggcggc gttcgtcacc gacatcaacg tgctggatcg ggcactggaa cccatcgccg
     6361 atccgctcga cgacatcgtg ttcgtgctga tcggactcgc gggcctgtac tggatcggcc
     6421 gcgtcgtcgt cggagaccga acacatcagt gagcaactcc accgatccag cgcacgagcg
     6481 accatcgacg ggatcggcag cgccgcggca ggcagggcag cgggcagggc agtgggtgtt
     6541 gctgtcctac cgcatgcccc gcgagccgtc caccccgcgg atcacggtct ggcgcaaact
     6601 caaacgcctc ggcgtcgccc aactcggcga cgggctggtc gcgctgcccg ccgacgcccg
     6661 cacccgcgaa cacctcgact ggatcgccga cgagatcctc gccgccggcg gcaccgccgg
     6721 cgtgtggctg gcccaaccaa ccagcctggc acaggaacgc cgcctggcac agaccatggc
     6781 cgccgcccgc gccgccgagt accgcgccgt gctcaccgaa gccgaacaag cgcgctcact
     6841 cggcgaggcc gagcgacgac gcgccctgcg caccctgcgc gccgagctgc ggcgtatcca
     6901 ccgccgcgac tacttccccc cacccgaacg cgacaccgcg caggccgctg tggacgccct
     6961 gcaccccgac caccacaccg aggagaccgc atgaagtggg ccacccgcga acacatccac
     7021 atcgaccgcg ccgcctgcgc ctggctcatc cgccgctgca tcgacccgga cgccgccttc
     7081 gtgttcgtca ccgaccccgc cgacgtcccc cccagacgcc accccgttcg acatgcgcgg
     7141 cgtcgacctc ggccaccacg gcgacgactg cagcttcgaa accatcctgc gccgccacga
     7201 cctcaccgac cccgtgctct ggcgcatcgc cgaaatcatc cacgaagccg acctcgacga
     7261 cgaacgctac gacgcccccg aagcccccgg cctcgacgcc atcctccgcg gcctatccat
     7321 gatcggcgac gaccagcaca ccctcaccat caccaaaccc atcttcgacg gcctctacga
     7381 gtactaccac cgcgcccaga tgctcggccg cgaacccgca tgaccgcagg gaacatccgc
     7441 cgcgccaccc tcggcatcct ggccgccctg ctctgtgcaa gcctgctcgg caccgatcac
     7501 cccgcgacag cgaccccctc atcagcggtg cccttgctgg aagaagccac cccaccagcg
     7561 aatgccgtcc tcaccgaacc ggtcgactgg gtgtacctga ccttcgaccg actgatcaac
     7621 acgttcagca tccgggtcac cggccccaac ggccacgacg tcgcccgcga caacgccatc
     7681 gtcaagcacg acatgatctc ccagccactg cacacactca cccagccggg cacctaccgc
     7741 gtcacctggc aggtcatcga cctcgacggc caccaggcca gcggatcaca cagcttcacc
     7801 atcacccccg gcgtcaccac gacccccgaa aacactgcca ccacaccagc caccaccccc
     7861 cactcagtac cgccgacagc gccaccagcc accaaccagt ccacgatcac cacgccgctg
     7921 gccgccacga tcgcactcag cctcctggca ggactaaccc tcctcaccat tcgtcaccgt
     7981 cgacgcgtcc gcgcatcacg tgcgcagcgg ccagaccgga catgacgaca accgcagtca
     8041 cgagacattc ggtcggcata gctcccgtag tcctggccta ccagcgcgaa agccaatgcg
     8101 gtgtcagatt ccaacaacac cagagccatc gactcaccgc cagcctggcc gtgagaagct
     8161 caacaagctg acttgacagg gaaccgcaac ggggcgacca gccgttctcc aggtgcgagc
     8221 tgcttccacc actgggcggg gatgtcccac ggtgagaccg tggcgatcat gcggtcgtac
     8281 ggggcgtggt cggggtagcc gagcccgccg tcgccagtga tcacgtgcac gtcgccgtag
     8341 ccggcggcgg ccagcgcttg tgaggctttc gcggtcacgt ccgggtcgac gtcgatggtg
     8401 gtcaccaggt ccgcgcggcc ggtcaactgg gcgagcaggc tggcgttgta accggtcccc
     8461 actccgatct ccaggatgcg gttgcccggc tggacgtcga gttggtcgag catcgcggct
     8521 actagccaag gtgccgacgc gcaggacaac gaccggccgt cctcgaaccg gtgggtgacc
     8581 accgcctgcc acgggtcgta agcgaccgcc aggtcggcgt ccggcacgaa ctcgtgccgc
     8641 ggtgtgtcgc gcaaaacccg ctcgacgtcg ctgtgctttg cgtgcccggc cttctggatc
     8701 ctctcgacca ttgccgcacg tagcgcttcc ggcgaagtag tggtggtgtg catcgttcct
     8761 tcgtatcaac gatcgtcggg ttggcgggca tcgttagtga tcgacacggg ctgtttctcg
     8821 ggccgaggaa gcaaacccgt tgtggtgcaa cggcttcact aggacccgcc ctacgggttc
     8881 gctggagcgt tgacgttgca ggacatcgtc ttcacgctgc gtgccatggc ctcttcggcg
     8941 caggctagtg ctgtcgtgag gtctgccagc agtgtggccg ggagcgtgcc gctgccgagc
     9001 gcgcacgctt cgaccgaatc ggacaactcg cgcgcttggg agtcggtgag cagctcgcgg
     9061 caaccattgt gggcgagtac atcgcgagcg acgtatccgt ctcgtgtcgc ggcggcgtag
     9121 tcgatcagat caacggcgat ctggtgcacg ggtggatcgt caacggtgcc gatggcgtcg
     9181 atgaaggaca acccgagccg tgtgtggaag accgccaagc cgggcgcgga ggtgtcgagt
     9241 cggtggtact ggttcaggag cgtgggcaga tcggcgacgc ccgaggcgcc gtggcactgg
     9301 atggtcaggc aggcggtcac ggcgttctcc caagggtctc ctggtgttgt gtcggccaag
     9361 agggtgaggg cgctgtcggt gtccccggat acggcgtggg cgatgaccgc gatctggcga
     9421 ccgtcaagca tccgtcgccc gacgcccttg tacgcgtcga gccgggcgcg tgcctccgcc
     9481 cagcggccgg ctgcggccag agcgcggcca ccggtggcca gcaggactgc ccacagccag
     9541 ctgcggatgt gctggtgcgt ctcggcggag tcggtgaggt cggccgggat ctcgatgccg
     9601 tcgacgatgg cgtcagttcg ggcggagacc gcggtgaaca gggtgtcgat cagcgcgaag
     9661 gcgcgctcgc cctgaccctc gcggatgtag aggcgggcga ggttggtgat cggttcgaga
     9721 gcgaggcggg ctacctgcgc gcccaagggg cgggcgcgca ggtagatgtt cacctgctgg
     9781 tggcaccacc gccgggccag ttcgggcagg ccgcagtcgg aggcgatgag cgccgcgttg
     9841 ttgtgcacgg cggcggcttc ggcgagctcg ccgctgtgct cgacttggcg tgctcggtcg
     9901 cacagctcgg ccacccgccg ggccagcggg aggcaggccg ggcgggttcg ggcaacgagg
     9961 gggaagcggc gggcgaactg gccggcgggg tccacgggcg tcactcccag gtgacggtca
    10021 tgggcttggt ggggcggtcc aggaccacga agccggggtt ggtgtccggc tggggcgcgg
    10081 tgtcgggaat ggcgaatcgg acggtgctgg cgcggaagcc ctggtcccaa gtcgagatct
    10141 cgaccgagac ctgctcggcg agttcctgcg cgttggggcc gtggccgatg acgccgacct
    10201 cgtagcgtcg gccgccgtcc ggatcggggt ccgcggcgcg gatggtgagg taggcgaggc
    10261 tgccgtcggc ggcggtggtg gccatcgcca ccgaggggaa catcggccgc acaaggccgc
    10321 tttccttcgc agcgggagcg acctccatgc gcatcagcgg gttgggcagg tggcaagcca
    10381 gccagagatc cagccattcg aaggattcca tcgggacgaa gtgcacgccg gtccacactt
    10441 cgcaggcagg gctgtcgaag acgccggtca gggtgtccgg gtcggtggcg tggttgttgt
    10501 ccttatggat ttgcagcgtc acctccccgg tgccggtgag gtccagaacg cggcgagcgt
    10561 cgtcgccaag gccacgcagc ggcatgaaga tcgccatctc gctgcccagg ctgcgccagc
    10621 cgtcctggtc gcgttcgaag acgatgctgc gagaggcaca accacgcagg cgcaccggag
    10681 ctaccagacg tccgccgggt gtgagctggt cgagccaggc agccgggacc tcgtgggcac
    10741 cgacggtagc gatgacgcgg tcgaaaggcg cagtttctgg gtggccgagt gcgccgtcgg
    10801 cggcgaccgc ctcgacgttg tcgatgctgg ctgcggccag gtgctcgcgt gctccggcga
    10861 cgaggtcctc gtcgatgtcg atcgtggtga catgcccgtc ggcgccggtg agggtggcca
    10921 tcagggcggc gttgtagccg gtggccgcgc cgagttcgag cagccgttcg ccgggctgga
    10981 tgccgagctg ttcgagcatc atggcgacga tcttgggctg ggacgcggcg ctgattcggg
    11041 tgccgtcgcc ctcgtgtttg gtgtagacgg gctcgtcggc gtacgcctcg accaggggga
    11101 cgtcgggcag gaacaggtgt cggggcacct gccggaacgc ggcctccaca gcgtcggtgc
    11161 ggacggtgcc gtccttgacg aggcggtcgg cgagcttggt acgcagctcg tcggcggagc
    11221 cggtggaagc gtcactgacg gtggttgtca ttgcgggaac cctaacggtg ttggaggtgg
    11281 tcccggctgg tgcctgccgg gtaggcgtgc tgtaaaaaac ggtgtcgacg gccagcgcgg
    11341 cgagggtggc ctggtcggtg ccggagagac cggcgcggtt ggcgtggaag atgaagtggt
    11401 gcgccaggac ggcgcgcagg ccccgctcga ggtgtccggc gcgagcgagt tcggcgagtt
    11461 ggcggccggc cgtgtcgaac gctgtccacc aggtctcggg aaccacgtcg ggggcgacgt
    11521 cggcgacctt gtgcgtgttg gtggtcatca gtcggcgcac ggcttggctc aaccgctcgg
    11581 tgtgcggaga gttgttggag tggggttggg cggtgggccg gagcgcagcc accttgtccc
    11641 agacgtcgcc ctgctcgaac cagtccagcc cggcggcgcg cagcatcgag ctgaacagca
    11701 ggacggtggt ctctctctga cccaaggcag cgggtttcgt ggcacgggcg aggcagtggc
    11761 gactgtcgtg gtgaaacagc gagtgcgcga tgtccatcgc ggcgggtcca ccgaaggcaa
    11821 gggtttcggg ttcgtagatg ccgcgagtcc agcgcgcgag atgcccatcg gcctccaggt
    11881 cggacagcag cgtgtcgacc gctttcgtct cggggttgac cggttggtaa cgcagccgcc
    11941 aggcgggtgt cttgcgcagg tgccaccacg tgtcgagttc gccgtcctgt tgggcctggt
    12001 cgagagcggg tacgagcagg gtcgcggcgg tgtgctcggc cgtggtcggg tcggcgaact
    12061 cgaccaggta gtggtgccag ctgtccggca gcatcagcgc ggaatctcct ctcggtcgga
    12121 cggatcgcgt tcggacggat caggtgatga gcaggccggt gccccagcct gtcgcgggct
    12181 cgatctcagc ggcgagggca gctaggccga ccccggcagc gccttcgagg aagccggggc
    12241 cttcgggaac ggcctgggcg caggcgcggt gcagcatctc ggtggccagc gcgcggagtc
    12301 gggaagcggc cggctccggt gtgtcgatgg cggtatgagc ggtgatccgg gcgagtccgg
    12361 cgtagccgtg gcacagcgaa gcgtcgctga tcaacgcatc ctgttccggg tcggtcaccg
    12421 cactgatcac ggcttcctcg gcgatctggc ggcgatcggc gtcgtcgagg gccagggcgg
    12481 cgaggtgcag ggtgcgggcg atgcccgctg ttccgtagca ccagctcggg cgtcggctgg
    12541 ccccgctgtg ccgcacgtac atcggcgtcg aacgcgcctc gtctcgggtg accatgtagg
    12601 gccaccggtg cccgctcgga gtgcttatgc gccaggagtc cagccacgcg cagatcgtcg
    12661 cgacggcctg gcgctgcccg tccacggcga tgccccggcg cagggcctgg gccagcagtg
    12721 ccagcgggcc gccgatgccg tgtgctacgc cgaagttgcc gtggcctccg gggaactcgt
    12781 cgtcctcgtg gccggtggga ccggtgaggg tccaccaccc cggcagggcc tctccttcga
    12841 ccatcaccgg ttgggtgagc cgcacgaggg cgcccagaac ggccggcagg gcggtgccgt
    12901 cggggtcgtg gtgcagcaga tgggcaccga gaccagcgag gccccgaatc gtgtcgaact
    12961 cggccatctg cggcaacatc ccgacgacgt ccatgcgctc gtgggccttg tcgacgcggt
    13021 tgtgggcgtc ggcggcgatc tgccgggtca agggcgtgag ggcggactgg tacgtgccgg
    13081 gacggactgt ggcggctccc gcgagggcgc gcgcgactgc cggcgcgccg tagaacaagc
    13141 cggtgctcgc tccggcggtg atcggcttgc tggtgacggc ggtcagccag tcatgggcgc
    13201 ggtcgaacgg ccgtatcccg gcggctgcca gctcgatgtg cagcagtgcc acaccaggag
    13261 cgccgtgggc gagggattgg tgccaccacg gctcgtccgt gggcaggtgg ggggcgtccg
    13321 gccgggcgag gcgatcggcg atccccgtcg cgtactcgac cgcggcatcc gaggcgaggt
    13381 cggcgttcat cgcggtcctc cggtgcgggc ggcgaaggtc agggccgcgg tccgggccag
    13441 gtaaaggcac accgccttgt cgtcgggctc gatgccgtag gcccgcagga agtgcgtgtg
    13501 cagcaacgag cccaaggcgg cgtccgggtc gacgccctcg gcctcagccc cggacaggtg
    13561 cgctcggtag gcagctacgg tctgggcgcg ctcggcccat gtcgcgacga ccgaagccgc
    13621 acccggcgtg ctgcgcaagg cgcggaaatt ctcggagggg tcggcgaggc attgtgcctc
    13681 ggtgaacacc ggccggggca cgacggtagg aggtttggcc gggacatggt cgaccagcca
    13741 ccgcatcccg gcctcggtcc ctcccatgaa ggcgacggcg atggcggcga agttcgccgc
    13801 ggccagagca tggtcgtgcg gtcgcgcggg ccaggcgagc tcggcgagca cggcgcggga
    13861 gtcagccgtg aagaacgcct cgacggctga tagtgccgca cctgagcccc agcggccggt
    13921 ctccgggtag gaggtcgcga aagcgatgtc gcgcagcagg ccgaggcggc ggagccggtc
    13981 ggcccaggcg ctgacccggc cggccgcctc gccgaacacc actggctcag tgctgaggag
    14041 actgatccgc aagcgcaggt agtgctcgtt gccctcgcgg aatcgcagaa accaccaccg
    14101 cggttgggca tcgccccact ccgccagcag tgcgggcagg tgcttggcga gcacggtgtt
    14161 gtgacgttgc gggtcgccgt agagcttggc gaacagcatg ggggaaccac ccggcgacag
    14221 cccgtgctca cctggccgga cgatccgctg gggcgtcggg cgcggtggcc gcgtcgtggc
    14281 ctgcggctga cagctggcca tgggcacgac gacgtcgtga gcacggccat cgagccatcc
    14341 ggcggcgtcc tcagcgggtc cttcctccag caccgcgtgg gggtgggtac cgaggtgctc
    14401 gcgcagcagg acccggtgtg cgtcctcgac gagatcgagc ggcaaccgcc agtccccgtc
    14461 gaccaggaac accgcctgcg ggaggcggcg gcgggtgcgc cactcggcca gggcgctgtc
    14521 ccaggtcgcc cagctggagg tccggtcggg aaggtcggct gcggccaacc gccaccgggc
    14581 cggggacagc acgatgcggc cgaagcgcag ccgaggaaga aacggcaacg tggccgccgt
    14641 gccccagtcg aagtcggtga cctccgcgca gtgtgcgcgg gtcagttcga ccaggaggcg
    14701 ggccagcggc ggagtgtgtt tgcgtaggtt gagtgcgtgc aagccccacg cttcgaccct
    14761 cgcgccgagg gcgggtgcgg tcagatacag gcggtcgctg tcgcaactga ccgccaagtc
    14821 cgccgccgtg aggaccgccg ttgacgcggc ggtgtcgcgg tgttcggcga ggctgacgat
    14881 ggttggcagg acctgggcgc tgcgggcgac gtgtgcggtg gcggggtcca gaggcgggaa
    14941 tgacaactgg gcctggatta ccccgtcaga cgcgggcggg gcgagcggcg tgatcagcat
    15001 tcggcggtcg tgttcgtcga acaggtgcag gaaacggccg ctgacgacgc cggccgatcg
    15061 cgagactgag gtaacgacga gctggaagtt gccctgcttc agggcttgca ggctcgggga
    15121 gtcgacacgg gcgcacaact cgaggtgcga gggcagccgc atcgagtgca caggcgccag
    15181 ctccagctcg gcgatcaacc tctcgccgag gacgacctct tgctgaccgt ccaacgcggc
    15241 ggcctgggcc aacgccagca gccgttcgtc ccgaggcgtc tgctggggtc gtgtgaccac
    15301 tccgctggtg ccggggtagc cgtcaggcca gccgatcccg ctgtcggcaa tgacctcgag
    15361 cagtggcacc tgtgcgccgg tgccgaaccg ctggtagaag cgtcggtgga agtccgccca
    15421 ggctgccgta ctgctggcgc gggaggtcag gcgcgccagg accagcgcgg cacgttccgc
    15481 ttcgcgggcg actgcgctgg ggagcacgac gtccaggtcc agccgcaggt cgaccgtgac
    15541 tgggctccgc cgtgacggag ccaggcggct catggacgcg gcggcgtcgg tccgtagcct
    15601 gcgccgcgct tccgctgggc tgttccgatg tcgccgcaac atgtcgtgga tgtcgttcag
    15661 cgtcatgcac cgctcggtgg cagcctcgcc gaccgtggcc agctcgcgca ccaagtggcc
    15721 aagtgcgtcg ggctccgtgc tcggcgcatg gaggttggtg acgagcacgc gacgagcgac
    15781 caacgtggcc agcaagccgg tcaccgtgct cccggcggtg ctcgggaact cggcctgtac
    15841 ctgctcgcgc atgtcatcga aaggaatcgg tgtccgcgca gctcgcacgg ccgcgcgcac
    15901 cgggccggtg tagcgaagtt cgacttcgac tgcgccggtg cctcgatggt tgacggtcgg
    15961 ctggtacgga accacaagcc gctcaccgcg caccatcaac gtggagttcg cgacgaggac
    16021 caagcgctcc aggatctcgg cctgaccttc caaccgtcgg atgacctcgg ccagccaccc
    16081 ggcgtcggcc gcagcgtccg cgcgatgatc atcaccccaa cgctgagagg gatccgcgtc
    16141 gaaccgcgcg gcggtgaccc cggcgaacaa gccgttggga gtcggacggc cggtcaaccg
    16201 tgccaggtac cgcagaacgg acagcaccac gcgccgggat tcgcgctcgc tggcaacctg
    16261 agcgccacac aggttgtgga cgcggtcagc aaggacaggg ctggccaggc cgatggcgtc
    16321 acggacggct tcgacctccc acacttcgcg cagccagtcc acccacgcgg tgacggcgtc
    16381 ggccccggtc gcggtcagcg tcggccacgg cggaagtttc agctcgccct ctgcaacagc
    16441 ccggaccaac aggccacccg cggctcgaaa gccgacgcgg tcgggcaagg ccgtggacac
    16501 gggacacctc tccaaagcga cggatggaaa ccggacgccc gcccaagaag cccctggcgg
    16561 gcgtccggtc gctcgtgaca atcaggcggc gctgatgcag gtcgacttct cgcacgtcgt
    16621 cccgcagccg tcatccgtca tgttgatcag atgcgccggg tccaccacct cgaccagcgt
    16681 gatgtcgagg tcgaactccg agcccatctc gacctccgcg gcgggcgtgg ccaccgtggt
    16741 cggcgaccac tccatctgaa ccgtcacaga tcctccttcg tgggttttac gctccgagtc
    16801 ccggcgagtc ggccgtgact tcgcccgcca ggcggaccag cccggaactc gaccgaggta
    16861 ccgagcgctc ccgccagcac acccgcgagc ggaattccat cgaagtggag ggcagtccta
    16921 ccaccacaca cccctcgacg gcacgtcccg gtgaaagacg cttccggata ctcgggctgc
    16981 gccgaagcgg aagctcgccc ggaccgcagc gatatcagtc aaacccctgg tgatcaacga
    17041 tagccagagc gccgacgcgg cgtcgatgag gcggcaatga ggcgtcatca cctctgacct
    17101 gcataaacgc cttttcagag gcggtagtcc gaacgggtac agctcgccga gcgggtgatc
    17161 agccttgacc cgtagctggc tatcgtggca ggtgaccgac ggggtgaggt ggtgttcatg
    17221 agtgaccgac gagatgcctt cgccgcgcgg cgtgagcaga tgggctacac ccaggagagc
    17281 ttcggcgcgg cggtgggcgt ggagttctcc acggtcggac gctgggaacg cggcaccctg
    17341 accccgcagc cgtaccgtcg accgtgtttg gctaagaccc tcgatgtgag cctcgaccag
    17401 ttggatgcgt tgctcacgcc gaaccggcaa gcttctacca ttgccactga accagccgac
    17461 cctgcggagg ccgacgacat gaaccgtcgt gacctgctgc gcttgttcag catgaccggc
    17521 gcgttgctcg cgctgcctgc tggcgagaca gtactcggcg acgtcgaccg gctcgccgcc
    17581 acagctcacg cgggcacggt ggacacggcg ggagcagcgg agttcgccca gctcaactcc
    17641 cacctgtggc gcgtgtacgc actgtcgccg accaaggccc aggtgctgcc gctggtccga
    17701 gcccaactcg gtgtactcag cgactccttg cgacgaccgc agacaccgac catccgacaa
    17761 cggctctgcg agctgaccgc cgacctcttc cagttggcgg gggaaatctt cttcgacggc
    17821 aaccgataca ccgacgccgc tcactgctac acgcttgcgg caacagcgag caaggaggcc
    17881 gtcgcttccg acctgtgggc ctgcgcgttg accaggcatg ctttcgtcgc cgtgtacgag
    17941 cgccgattcg cggatgccgc gccgatgctc gacgtggccg ccaccatcgc acgtcgaggc
    18001 gaccccagcc tgtcgacccg acactgggtc gccgtggtgc aggccgagac cttcgccggc
    18061 ctcggcgact ttgactcctg ccaacatgcc ctcgacaccg ctgctgaggt ccagcgccta
    18121 cggggccagg tgcacaacgg cggctggctc cggtttgatg gctcccgctt ggctgaagaa
    18181 cgcggaacct gctacgtcac gctgggccgc cacgacctag ctgaagcggc tctggtcgac
    18241 gccctgcagg gcaccttgac cgcccgccgg aaagcaggcg tcctgaccga cctggcgatg
    18301 atcggcgtgc accgtcgcga cccggaccag gtcgtcacct acgccgacac cgtcctgact
    18361 accgcccgcc agacccgctc gggggtcatc gcacagaagc tgcgggtcct tcagccacac
    18421 cttgcttcct tgctcaacga ccaacaaatc cagcgactcg atgccgagat caccaaactc
    18481 gtcggcaacc gcgccgcgtg atggaggacg accgaatgca caacgaccgt ggccgcgtgt
    18541 tccgcgaggc gtggatcgcc ggagtcacca agcactaccc cggtgagccg aagcctggct
    18601 acatcacccc gtgggaccag acccccgact gggaacgcga cgccgcgacc gccgtgtacg
    18661 accaggtcgt cgccttcatc aaggccaccg acggcgccac caccaaactg accccagacc
    18721 agaaaggccg ctttgtggcg ttgtgctgga tcggccagat cttcaagcac ttccccgagc
    18781 cgaagccgtc gtacgtcgcg gactggaacg atttgccgga ctggcagaag gcgacggata
    18841 tcgacatctt cgagcgcatc gaacgcgatg cctgaccagg cgacgatcga cgctgcggcc
    18901 gtcgatgctc gccttgccga gaccgagtac gacgacgctc aggcgtggct acacgcacgt
    18961 tcgaccgcgt tggagccgct cgcagccgag gtctgggtca ccgacccgga gcaccgccac
    19021 gtgctgctcg tgcggcaccg ggtgcgaggc tgggtaccgc ctgttatggc aagtatttga
    19081 gcctgtctca ccgttccgtg gcgttcgtac cgctctgtcg cctttgattc gtgcccgcta
    19141 ggttctggga gccgtatagc tctcactgag gggcgaacga tggatcactt cttcgtgtcg
    19201 agggacaagg tccgtcgata ttttgagccc gtgcctggtc ttggcgttga cggtctcact
    19261 gtcctgcggc ggaagggttc gccgcaggat gggactccgt tcttcctcgg acgggatatg
    19321 cggccggtcg agccactgtg ttcgttcatg ttcgaaatgg ccaagactca ccaacctaag
    19381 acgttgtccg attacaccta cgacctgctc gacctcgtcg acttcctggc tcagctggaa
    19441 ccgtcgactg acgtcctgtc ggcgactgag gaaaacctga tcgcctaccg cgctgagcgg
    19501 accgagctac aggacaagcc gaacgcgccg gcgacctgga agcgccgacg agcgctgatc
    19561 aacaacttct atgagtgggc ggtcgaggcc cagtggctgg accgcaagcc ttatcgccgg
    19621 ctgcgcaacg gccgggacgt cctggcctgg ggtgcggtat cggatctgga cattcgccat
    19681 ctgacccacc ggcagtggcg attcctcaag caggtcggct tgcggggaat gcttccagca
    19741 gaccgggtcg acctgtcgtt ccgaggttcg gctccgctca ggaacgcggc ggcagcggag
    19801 ctcgcggtga cgacagggat gcgcttgagg gaattcacct cgctactgga catcgaggtc
    19861 ggactcccgc gtcgtgactg cctgccggtc gacgtacggc tggagatgat cgcgaagtac
    19921 agcctgcccc gcgatgtgac gatccagcat tccgtgatga aagagctcga cctttaccgg
    19981 cgcaccgagc gggccgccac gattcgcagg gcggcaccgg cgttgaccag gcgcagagcc
    20041 gagctgttcg tcgtcaccga tatcgacgag cggcagatga aggtcagcgg gcggctgcat
    20101 gggagacgcc ggacgttctc gatcgagaag atgaccgcgg agctgcggag aatcgcggtg
    20161 accgaagggc cttgcggtct ggagccgatg gcgttgttcg tcggccgtgg tggccggatg
    20221 ctcagtaagc aacggtggga acagatcttc gatgatgcgc acgccagatc tcttcggatt
    20281 gcagctgaaa acggtgtcga tatggtgatg ccgcgcaggt tcagaatcca cgatctacgg
    20341 cacacgttct cggtttacat gttggagcag ctcacccagt tggtgattgc acaggagacg
    20401 gaccgcagac tcaacggtgg gcacaatgct tacctggccg accacatctg ccgcaatccg
    20461 cagttgatct tgcagcggct actcggacat ctgaatcctg ggtcgacgat gaagtatttg
    20521 cgttacgtcc ggaacaccaa cgttcttgtg gcccaagcta ttgccgagtg gaatgaatca
    20581 gacaagacct acgcggagta cgcggctctt gccgcggaac gcgcggtcct gtgatggccc
    20641 gcagaggcga acgtgcttcg cgcccacgta cgatggtggt gccagaagtg aaacccgcca
    20701 actccgatag gatcggggac cgggttatag tccgggaacg gcgagggcga acggtgcggt
    20761 tgagtatcgc cccctccctg ttccgatgtt ccgtcctggt cgcggagctg gcggacgagg
    20821 ctgtggcgta cgcccatcgg gtctcgctgc gcaagcccga ttgctatttc acggccgtgc
    20881 gggagctggg aacgttcctc gatgaacact tgccgaccgt cgggtgcgag cctgcagagg
    20941 cgcgtttggc cgggatgaaa atcgatctga tcgaagccct cttctgctgg gaggcagatc
    21001 tgcggaggcg gcacgggctg cgatcagcgg agccctaccg caaggccgcg gctgtgctgg
    21061 cgctgatcga tatgcgtgcg gagcgcgacc cgaatgttcc ggagaccctt cgtcgtcgcg
    21121 cggcggggcc tccgacatac aagcgccgcc ccaacgcggt ccttgacgaa tactccaacg
    21181 aggaacggtt ggcactgcag gaggccgcaa gggccgacgt ccgggcactg gagaaacgcc
    21241 tcactcgggg gcagcatctg ctgagatccg gagctgaccc ccgccgcgaa ggctggcatg
    21301 acctcgccaa cctggtctgg gccgccaagc atcgccttct gacgaccaca gatctcctcg
    21361 agcacctgcc catgaattcg tcatcgtggt cgcagccgat caaggacgtt atcgaagcga
    21421 acccgcctgg cagggaacgt ggagtctatg cctgcttgaa agcgatcaac cggttgctgt
    21481 tcccgtccga gcaggacctg cagcccttcc gggtactcct gctgctgggc atggccgact
    21541 gcacccccga ggaactcctc gacctgcgta tggcggacct ggagttctct gacgcgggcg
    21601 tgcgagtgcg gcagaccaaa ctccgcgcga atcgcatccg ggctgatttc cacccggacc
    21661 ttcctgatag caaggccagc acaggcgatg tcgcggatct ggatggggac accggaagcg
    21721 aggtgtatct tgccgtcggc aggtgggatg tcggtgggct cctacggcgg ttgatggagg
    21781 tcacctggca ggcacgcgaa tcgttcgact ccgaggacgt gctgttcctc gcggtcgaag
    21841 cgggccgtcc caggaccact atgcgggcca gagtcgccac atggactgag gaccacaacg
    21901 ggttcagcgc gtggatcagc tggcatcgca acgacgacgg cacacccgct atggcgatct
    21961 ctcagccgca ctacgcccga aggctccgca agaccgtgaa aaccgcccgt gtggccgccc
    22021 tcggcggaac cctcaccgat gtggcggcgg acgaccatca catcgaggtc ttccgtcacc
    22081 attacgccca cggaacgacg gcgctaacac tcgccggacg atccatcaac cgcgcacaag
    22141 aacgcgtctt ccacacgatc acgaccaagc cgatgctcct cgacactcaa gcagagcatc
    22201 gattggccga acccgaggtc gccgaggccg cggggatgac tgtggaacac gccgccgcga
    22261 tgcgcgccgg ggagtacgac atgggcctga ctcactgccg tgatccctac gattcgccat
    22321 tcacccctgg cgggaagccc tgccacgtcg ccccggcgat gtgcatgatc tgccgcaacg
    22381 ccgtcgtatt catctcgcag ctgccgaggc tgctgctgct ggcagcccac atcgagcgga
    22441 tgcgcgacgc cctggacccg atccgctgga cggcaatctg ggggacccag gccacagccc
    22501 tggccgaggt gttcgcggaa tgcacagcac agcagctcca cgacgcccac gaagcgatag
    22561 gcgaccaggg gctgcggctg gacctgccgc tgggtatgag gacggagtat gaccggtgag
    22621 cacgacgccc cagccgacgg cagtgacttc cacccttgtt tccgctgatg aggcggtctt
    22681 cggatccggc cacccgctcg tggaaggcgt ccctattccc gagttcggcg agagcaggtc
    22741 ctggagtttc gggtgtattc gccgtccgag caacgtccgc ccggcggcgt ggaaggtcaa
    22801 cttcacggtg atcgattccg tctggaacct gcggatccgg gaaatctgct tcagcatgct
    22861 caaccccacg cacaaagtca ttcgggacgc ggggatcgct cttgtcgccg agccggcggc
    22921 gcacagcacg gtccggcaat gcgcctacac actgggcaaa ctcgctgcct gggcgttggc
    22981 caacgacatg cccgccgaca tcgcggcctg gcgcgaagaa gactgggccg gattcgtgga
    23041 acacatcacc gccagggcga acgcgctcaa acccgacgcg acggcgctga gctggctctc
    23101 gacgctcgcg ccggtactca ctcacggcgg catggctcaa gggctgtgga acaccgatac
    23161 tttccgggag atcaggcacc gcagcgatac tccgtcgacg gcatccatac cgccatcaac
    23221 gtggtggccg cttctgcggg ccgcatgggc ctacatccac gagttctcgc cgcacatcct
    23281 cgacctacgc gatcagctgg cgcagcaacc agatcctggc gacagccctg aacgtcgacc
    23341 ggccttccgc actccggcgg gaaacgacga gctggtggac aactggctcg cgaaccccga
    23401 caacctcgtt ccagtccaca agtacgacca ccagacgaag tcggctgggg agccgatctg
    23461 gcatcatctc gcgctgacga tcacaggcgg caccaacacg gggctcttcc agaccacaag
    23521 gaagggagcg gcgcagcgcc ggcgagacgc cgtccttcga gccgtggaac gggggcaggt
    23581 acaggcctac tcctggtcag agatgcgggc ccggaccgac gtggtcaacc atcccgccat
    23641 ttacctcggc cgaagcacag ctgcactcga tcaggttctc gacgactggc ttaccaatcc
    23701 cgacaacctg atcccaatcc gcaccaagca gccacgtgcg ccgcgctccg acctcgaacc
    23761 tggaacgatc atttggactg cactggaagc actgatctac ggcaccgcgg gcacagcacc
    23821 ctttacacag cgctccgtga ctagcgccgc gcgcagacag aaggtcgagg acgctgccgc
    23881 ggccgggcgg gtacagaagc tcgccggaac catgacgacc cgctcacttc cgatgccctg
    23941 caaggacttc acctcagtca cccgtcagga cggaaccacg cggccgtggc gcggccagat
    24001 cagcgtcgag gaactcgcgg acgaaatccg catggtcagg gcggcatgtt atgtgttcat
    24061 ggcaggactg acgatgatgc gggactcaga gatccaggaa atcgagcgcg gatccctcac
    24121 tgcctattac ggagcgcccg cagtcaagtc ccgaaagctc aagcacgacc cggcgcaacc
    24181 ggaactcaac tggtggatca gcgcgccggt cgtcgaaact ctggcagttc ttgaccggtt
    24241 gtcctggcat cacactcacc tgttcgtcgc tctcgatccg cccagggtga ccgctcacaa
    24301 cgaggacacg gtgcgcggaa tcgatgccgc cggcgagatc gacttcttcg tcgcgggagt
    24361 caacgcttcc ctcgaacgaa cgggtttgga agagatcccg gccggccgca tccgtccgca
    24421 tatgttccga agaaccatgt cgatcatctg cagtcaagag cccgactccg agatcgccct
    24481 cggccatcaa ctcaagcacc tggcccgtcg taccttggcc aaccgaatca cccagggcta
    24541 ctcccgcatg gatacccact gggccaagga gttcgacaac cagctcgaac tcgccgccgc
    24601 tgggcgactc gtcgaactcc tcaaatcccg ccggtccggc accgacgtcg cagtcggtcc
    24661 cgcagcggcc aagctccact ccggcctcga caacgtgatt gcgacgatga acagagcccc
    24721 agctctgcga gctcaactcg ctgacgagca aatcgaggtc ctgctgttac gggatgagtt
    24781 tgctgacctg catttcggca cggtcaacca ctgtctctgg gaccccgctc aggcggaatg
    24841 ccagaactcg ctacccgaag ggcagcgagg gaaaacgccc gtcctgggag cctgccagcc
    24901 cgcacggtgt cgaaactcgg cagtagacca ggacaagcac ggcccagtct ggctcgccga
    24961 ggacgccgat ctgacgcgca tgctccgcga cccgcggctg gccacacccc gccgcgcagc
    25021 cctcgagaac cgcctgtccg aagtccggct gatcaccggt acctggctga ccaaggagcg
    25081 cccctgatgg ccgtctcgcc cccgaccgag accaagctcc gagcagcgat acaacgactg
    25141 ctcgacggag ttccgatcca cacagacggc gcactgacca aagaaaatct ggcccgcgaa
    25201 gcgggcgtca gccatgccac cgttcaccgt gctggcgaga ttctggccga gtgggacacc
    25261 cgagttgccc ggccggtcct gcgctccacc ggtgaggttc gtcgggccga gaagatcgag
    25321 gcactcacag ccgcgctacg cgccgaaaag cgggccgtca ccgaactgca ggggaagctc
    25381 gatgcgctcg ctagcgtgac cgccgacctc taccacgaga acctgacgct gaggaagagg
    25441 cttgacaaac aacctccagt gacctcaatg gataccagag cagccaggtc cgaatcttca
    25501 cctgttcgtg gcatcgagcg tgcacgaggt catcggcaaa cccgcccgct ctagcctgga
    25561 tcggtgaccc ctcacgcccc tggtccggac acactgcacg cggccatcgt cgacgccggt
    25621 ctcgcggagt tcgagttcga cgacgcacga atgtggctga agaacgcgtg ccacggcccc
    25681 atggcccctt ttgccgccga cgtctgggcc tttgacagca ccttccagca catccttctt
    25741 gtccgccacc ggtggcgggg ctgggttgtc cctggaggaa tggtcgaacg aggagagaca
    25801 cctcgacagg cagcgcgccg tgagctggag gaggaaacgg ggatggccgc cgacctcctc
    25861 gaactccctg ctgcggtgac cgtccgttcc taccgctcgg attggacacc cacgctcggg
    25921 ctgacctatg ccgccgttgt cgacccctcg cttcccctga acggcgaacg tcatcaatcc
    25981 gcagcatgga acccattagc gcaggactgg acaggcgcct ttcccgagga catcacaaga
    26041 atccgacgct acgcccaggc aggggcatca gcgcagtagt cgggcactcg tgggatgccg
    26101 ccggggcgat agaccatcgg ctcgtcctgg tggtcggcgg cctttcaatc ttgtcgagca
    26161 tcgagacgag gcgcaccgta cgtgctggtc gccgcgggcg ctgcccaact cgggttgtcg
    26221 gtggcggcgg tgccgaggtt gtccgcggcg tgcatgacgg tgagatgcga cgatgacgac
    26281 atggaggacg gccagagcga gaagggcgcg tcgcagctgc cagatggccg cggtgggctg
    26341 acggtggtgg ccggagccgc ggtgatgggg gcgctgaccg tggcggtgac gacgatggtc
    26401 attctgtcgt ccgcgacagc tgaatgcacc gacacctctg ggtcgatcct gtggtcttgc
    26461 aggccttcat catcggttgc gttgctgctg ccgattgggg
//
