LOCUS       NZ_FOKG01000010        10393 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Amycolatopsis marina strain CGMCC 4.3568, whole genome shotgun
            sequence.
ACCESSION   NZ_FOKG01000010
VERSION     NZ_FOKG01000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis marina
  ORGANISM  Amycolatopsis marina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900111885.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:41:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,708
            CDSs (total)                      :: 6,643
            Genes (coding)                    :: 6,572
            CDSs (with protein)               :: 6,572
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2, 5 (16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 22 of 71
            Pseudo Genes (incomplete)         :: 62 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 15 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:06:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 68187
            Orig. end                         :: 78580
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOKG01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10393
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="2"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10393
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10393
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5393](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5393
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    1035..1048
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     misc_feature    complement(1230..1245)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.68"
                     /tool="antismash"
     gene            1418..4618
                     /locus_tag="BM199_RS17645"
                     /old_locus_tag="SAMN05216266_11074"
     CDS             1418..4618
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="BM199_RS17645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11074"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_091674357.1"
                     /transl_table=11
                     /translation="MKWRSGGLGMGAASKIRYDRVETRWLFRLASPDPAHPLERIPSTP
                     RPWDKAGGEAMNMVGAMGSTRRRLDEVIKLFRRRAGLTQQQAADLAGLSVAGLRDLEQG
                     RVVAPRAGTLRRLASALELSAGEAEDLLRIGRSAPAPGQDLWVRVLGPLTIEVDGKEVD
                     PGSARQRLLLGLLALSPNLPVSRDALIEAAWGEQPPPKVVELLQTNMSRLRRRLQSARS
                     DAAQSKLLFATSGGYQLEVTEDQLDLLAFRKQAAQARRSMRDGDPLAAFTVFGESLSLW
                     RGAPLADQPALRIHPSVVALSTDWQDVVIDYARVAEELGRHADVLPLLRQVVESDPLNE
                     IAQARLMIALMGVGQQGRALSVFADLRKRLAEELGADPGPEVLDAHQRVLRQEVPQAAA
                     NDDAPVSAHRQLPPDIADFTGRDQELSVLHGLVSSALEGGPAAPIIAIEGMAGVGKTRL
                     AVHLAHELQVRNNYYEQQLYVDLHGHANEPPAEPGPVLGSFLHLLGVRGDQIPPDVNDR
                     AALYRDRLHDKRVLVLLDNAVSLDQVQPLLPAGSANLVLVTSRRSLALDGSHTIPLDVF
                     AMSDAEALLVRILGRDRVHTDIAAARRVINLCGRLPLAVALVARRLQSRPAWKLGDLAS
                     RLEEAADRMGELAAGTRRVRAAFDLSYQALDPEARRVFKLLGLHPGEDFTAGSTAVLAR
                     IDAGTARGLLDHLVEEHLVIAVSGERYRLHDLLRDYARDLLTEESADDRREALSRILRW
                     YLHAAGAARVFAPALRKRRPVLDDAPSAPLPEFAKDEDAFQWLEAERAALVAAVTVAHE
                     QGFPQTAWQLSSVLRDYFDRIGDWDLWIRTGEVGLAAARGSGDHLGEASVLLDLSSAYG
                     QLGDLDQAEEVVTRALELTRVIGDREQESWALSNLGIITAMREDWERALEHFNEALQYD
                     DMQLVVFNNMGAVYQRLGRHSEAIACFRRALDLNSGESNNWIAAVWMHSLGESLVSIGQ
                     YQDAISVLEEACARHREGHAALPEAETLETLGNAYVAVGRSADARQCWEQALGILTELD
                     HGHAGQLRARLKTDELSA"
     misc_feature    4580..4582
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5001..5393
                     /locus_tag="BM199_RS17650"
                     /old_locus_tag="SAMN05216266_11075"
     CDS             5001..5393
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005165143.1"
                     /locus_tag="BM199_RS17650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11075"
                     /product="ectoine synthase"
                     /protein_id="WP_091674358.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.7e-54, bitscore:
                     176.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRTIAEINETEADVKTANWRSKRLILAGDKVGFSMHETTLYAG
                     TVNQFWYANHVEAVFVVEGEGELVDSATGEVFQLRPGTMYLLNNQDKHEVRPTTDVRAV
                     CVFNPPVTGREVHDENGVYPLITEAD"
     gene            5661..7355
                     /locus_tag="BM199_RS17655"
                     /old_locus_tag="SAMN05216266_11076"
     CDS             5661..7355
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0071705 - nitrogen compound transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009153521.1"
                     /locus_tag="BM199_RS17655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11076"
                     /product="BCCT family transporter"
                     /protein_id="WP_143101846.1"
                     /transl_table=11
                     /translation="MLIWLQQKLGLRTNPTIFFVSAILTVAFVAISILFTDTVDATFKA
                     LSEFITTNLGWTYIFGVTSFLVFLIWIACGRYRHVRLGGKDSRPEYGNVTWFGMLFAAG
                     IGTILMFWGVAEPINHYANPPQSGIQPEVLEGLSAEEIAQVEVPSGAAAPLSNAAGEEA
                     MGFTLYHFGLHTWAIFALPALAFAYFAYRRKLPFRVSSIFQPLLGDRINGPIGKIIDIT
                     AVLGTLFGVAVSIGLGTLQINSGLGALFGIEQGRTAQVVIIAVVTVVAVISVALGLDKG
                     IKRLSNINIGLAVALLVFVLIAGSTVYLLRGVIETVGTYLTHLVPLSFWNDAFSGDNWG
                     WQGGWTVFYWAWTITWAPFVGIFIARISKGRTIREFVIGVLGAPVAFSIVWFSVFGMSA
                     MRIESGDPGKLVEPVVQDGDTAGALFAFLDSFPATEFVMAVAVLIVVVFFTTSSDSASL
                     VIDMLCSGREWNPPTRQRVFWAVLQGVVAATLIAATGREALDALSQVITVLGLPFFVIA
                     FLMMFCLVKALREDVTDEELLPSPRKLRSKEVPVIKSSANEDSEVLT"
     gene            7510..10056
                     /gene="otsB"
                     /locus_tag="BM199_RS17660"
                     /old_locus_tag="SAMN05216266_11077"
     CDS             7510..10056
                     /EC_number="3.1.3.12"
                     /GO_function="GO:0004805 - trehalose-phosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="otsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947417.1"
                     /locus_tag="BM199_RS17660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11077"
                     /product="trehalose-phosphatase"
                     /protein_id="WP_091674359.1"
                     /transl_table=11
                     /translation="MLTTGLGLDEVATLPAGLREEIGRIARTPRLLVGCDYDGTLAPFV
                     SDPDAAKPLAESVAALRGLAALHETSAVVISGRALRDLATLSRLPAEVQLVGSHGSEFD
                     AGFVRQLDRGALSHKQELHERLKQLIQDRTGVTLEVKPAGFAVHVRNADRHTAQRTLDE
                     VRGAEFAGVQVVEGNEVVELTVVPTDKGRALDSVRRDSAATATVFIGDGPSDENAFGRL
                     ASGDLSVKVGPGDTIADYRLRDPKDVALALALLKEQRHAWLHGEQATPIERHSMLANER
                     SIALVTPDGAVSWMCYPEPDSSALFAQLLGGTTAGHFTVSPARTGLPLGQRYLPGTMTV
                     ETRWSGLRVTDYLDHAGSDFRTDLIRVITGDVPAVVQFAPRPEFGQIPVKLVPDGDCLR
                     VVGTSDPITLYAPGVRWSIDQDGPHETARAVVNPAGKASVVLELRCGSTSARPHYLPEP
                     TRRALAGAYWVSWLNDRRLPQVERSLVARSALTLRGLCHDTTGAILAAATTSLPEEIGG
                     IRNWDYRYCWIRDAAITARCMVSLGSVKPAERFLGWLGRILAELPGPERLHPLYTLGGA
                     TLGPEAVIETLPGYAGSRPVRVGNLAGQQVQLDVFGPVVELITDLGAERGWLSEEEWAL
                     VTQMVEAVDRRWQEPDHGIWEERIRPRHHVYTKVMCWVAVDRALRLAETLGKPHRERWA
                     ELRAAIATDVLEHGWNAEVGSFTTAYDGDDLDAATLHIGLSGLLDPEDPRFHATVLATE
                     AQLRYGSTVYRYRRDDGLPGKEGGFHFCTAWLVEAYLLTGRRLEAEELFKHLVDSAGPT
                     GLLPEEYDPVAERSLGNHPQAYSHVGLIRCAQLLSG"
ORIGIN
        1 gccgaatcga cggtgacagg ctgattcgat tcgtcaacga ctggacgctc attcgactcc
       61 gggaactcaa cgattcggtt ctgtcggggc gctcgaagcc ggaagagctg atccgggaac
      121 tgaacgagag agtccttccg cgcctgcccg acgaccttcg tggcctcgca cccgaccgag
      181 ccgctcgcct gctcgtacca ctcggcctgc tcggtgcttc ggtggcgaag cacatgcagg
      241 aacggcacgc ctatctccgt gcccaaccgg cccggagcct gtccgccctc gtcactggta
      301 agagccgcgg aaacttcctt cgttacttcc gcgaactcgc ggagatcagc gccaccggcc
      361 atccgagccg ggacgctttc gcgtcgttgg tcaggtggaa cgtgcccacc gtgcgggtcc
      421 agtgggcagg gcagcctctc gcagtggtcg aaggagtctt ctccgactcc tccgtgcgca
      481 cgtataccag cggtgccggc gaggccgcgc tgctgattgt gctgaagaag tgcgaggcgg
      541 tcgaactggc cgtcaacgag ctactcgagc cgatctgtgc aggggatctc agcccctcgg
      601 gcgaggaagg ccgggaacgg gccgcagttg ccaccgccct gctgggagtc gtgcggcagc
      661 tgctggctga attcaccgag gacctggtgc gcggacggtc gggcggcacg agtccgacgg
      721 atgccgtcgc ccgattcagt gtgcactggc gactcgggga cgtgcccccg agttctgcgc
      781 ggaacgtcga gtacgtcagg cgtgatctgc tgctcggtat cggtgcgcct ggttttcgcg
      841 atcacctgtt ccggctgctt cccggtctgc tcaggaccga gcaagcgacg ctgtcggagt
      901 tggtgagcag gccgagcctg tccgaccaga ttctgcgggt ggccggcctg gggcacgcct
      961 cgtccgtgcc gcgttctgcc ggctggctgc acaagtcggt ggcgaagcaa gcctggctgg
     1021 ccgattacca tctgttgttc cggatgaacg ccgaggtgag tgcggcgcat ctggcgatga
     1081 ccaggaagtt gctgcccgac cgcgaccgag tcgtggaaga gacgggcaag caactcgaac
     1141 gggtgacgcc gaacggtgag tgttgcgtgg acaccgatga gacggtcctg tctcggctga
     1201 gtctcgctcg cgagcagcat cccctcgccg gttcgctacg agcttcgttc ctgagcgccg
     1261 tctcaggaac acacgctcac gccgagcgtc ccggattccc tgctgacacg gaggaattcg
     1321 tgcgaatgcg ctgacccaga gcatcacatc actccgctgt tactcgtcag cttgcgctgg
     1381 cgcgcacggt tcttgctggc gcgcgcacga tctgttcatg aagtggcgtt ccggcggtct
     1441 gggcatgggc gctgcctcga agattcggta tgacagagtg gaaacacgct ggctcttccg
     1501 gctggcgagt ccggatcctg cacatcccct ggaacgaatc ccatcgacgc cgcgtccatg
     1561 ggacaaggcc ggtggagagg cgatgaacat ggtgggtgcg atgggcagta cgcggcgacg
     1621 cttggacgaa gtgatcaaac tgttccgccg tcgcgcgggc ttgacacagc agcaggccgc
     1681 ggatctcgcg ggattgagcg ttgccggact gcgggatctc gagcagggac gcgttgtcgc
     1741 gcccagagcg ggtacattgc gcaggctcgc atcggctctg gaactgtccg cgggcgaagc
     1801 cgaagacctg ctgcggattg gccgatccgc tcccgcacct ggtcaggacc tgtgggtgcg
     1861 ggtgctcgga ccactgacga tcgaggtcga cgggaaagaa gtcgatcccg ggtcggccag
     1921 gcagcgtctg ctgctcggcc tgctggctct ctcgcccaac ctgccggtca gcagggacgc
     1981 gctgatcgag gccgcgtggg gggaacagcc gccgcccaag gtggtggagc tgctccagac
     2041 gaacatgtcc cggctgcgca ggcgactgca gtcggcgagg tcggacgccg cgcagtccaa
     2101 actgctgttc gcgacctctg gcgggtatca gctcgaggtc accgaggacc agctcgacct
     2161 actggccttt cgcaagcagg ccgcgcaggc gcgccggtcg atgcgagacg gagatccgct
     2221 ggcggcgttc actgttttcg gcgagtcgct gagcctgtgg cgcggggcgc cgctggccga
     2281 ccagcccgcg ctgcggattc atccatctgt cgtggcgttg tccaccgact ggcaggacgt
     2341 ggtcatcgac tatgccaggg tcgcggaaga actcggcagg cacgccgatg tcctgccgtt
     2401 gctgcgtcag gtggtcgaat ccgatccact gaacgaaatc gcccaggcca ggttgatgat
     2461 cgcgctgatg ggcgtcggcc agcagggtcg agcactttcg gtgttcgccg acctgcgcaa
     2521 acgcctggcc gaggagctcg gggccgatcc aggccccgag gttctcgatg cgcaccagcg
     2581 ggtgttgcgt caggaggtgc cgcaggccgc ggcgaacgac gacgctccgg ttagtgcgca
     2641 tcggcagttg ccgccggaca tcgccgactt cactggcagg gaccaggagc tcagcgtgtt
     2701 gcacggcctg gtgagcagtg ctctggaagg tgggccggcc gctccgatca tcgcgatcga
     2761 aggcatggcc ggagtgggca agacacgact ggccgtgcat ctcgcccatg agttgcaggt
     2821 caggaacaac tactacgagc aacagctgta tgtggaccta catggtcacg cgaacgagcc
     2881 acctgccgag ccagggccgg tgctgggctc gttcctgcat ctgctgggag tgcgtggtga
     2941 ccagattcca ccagacgtga acgaccgagc cgccctgtac cgcgatcgac tccacgacaa
     3001 gcgtgtgctg gtgctgctgg acaacgcggt cagcctggac caggtgcagc cactgctccc
     3061 cgcgggatcg gcgaacctgg tgctggtgac cagtcgccgc tccctcgccc tcgacggatc
     3121 gcacaccatc ccgctggacg tgttcgccat gtccgacgcg gaagctctgc tcgtccggat
     3181 cctgggccgg gaccgggtac acacggatat cgccgccgcc cgccgcgtca tcaacctgtg
     3241 tggcaggttg ccgctggcgg tggcgctggt cgcccgacgc ctgcagtcca ggcccgcgtg
     3301 gaagctgggt gatctggcgt cgcggttgga ggaagccgcc gatcgcatgg gtgagctcgc
     3361 ggcggggacg cgccgggtcc gggcggcatt cgatctgtcg taccaagctc tcgaccccga
     3421 agcgcggcgg gtgttcaagc tgctcggcct gcatcccggt gaggacttca ccgcaggatc
     3481 gaccgccgta ctcgccagga tcgacgcggg cacggcacgc ggtttgctcg atcaccttgt
     3541 cgaggagcat ctggtcatcg cggtgtccgg tgagcgctat cggttgcatg acctgttgcg
     3601 ggactacgct cgcgacctgc tcaccgagga gtcggcggac gaccgcaggg aggcgctcag
     3661 ccgaatcctg cggtggtacc tgcacgccgc cggtgcggcg agggtgttcg ctcccgcgtt
     3721 gcgcaagagg cggccggtgt tggacgacgc gccatccgcc ccgctgccgg agttcgccaa
     3781 ggacgaggac gcgttccagt ggctcgaggc ggagcgcgcc gcgctggtcg ccgcggtgac
     3841 ggtggctcac gaacagggct ttccacagac cgcatggcag ctgtcctcgg tgctgcggga
     3901 ctacttcgac cggatcgggg actgggatct gtggatccgg acgggtgagg tcgggctcgc
     3961 ggccgcccgc ggatcgggag accacctcgg cgaggcctcg gtactgctcg acctgtcctc
     4021 ggcatacggg cagctcggcg acctcgatca ggctgaggag gtcgtcactc gggcattgga
     4081 actcacccgc gtcatcgggg accgagagca ggagtcgtgg gcgttgagca atctgggcat
     4141 catcaccgcg atgcgtgagg actgggagcg agccctcgag cacttcaacg aggcactgca
     4201 atacgacgac atgcagttgg tggtattcaa caacatgggc gcggtgtatc agcgcctcgg
     4261 caggcacagc gaggcgatcg cctgcttccg tcgtgccctg gacctgaact ccggcgagtc
     4321 gaacaactgg atcgccgctg tgtggatgca cagtctgggg gaatctctgg tgagcatcgg
     4381 gcagtaccag gacgcgatct cggtgctgga ggaagcctgt gcgcgccacc gggagggaca
     4441 cgcggcgctt ccggaagcgg aaactctcga gactcttggc aacgcgtacg tcgccgttgg
     4501 caggagtgct gacgcgcgtc agtgctggga acaggcgttg gggattctga ccgagttgga
     4561 ccacgggcat gccggccagt tacgtgcgcg gctgaagacc gatgagctgt cggcctagga
     4621 ccccccagcc gggcactttc ccggaagagt gacgttgggg gtagttggcg gcgttggcga
     4681 tcttgctcgg gggtacttgc agacgcacca tcgctgaagc ggcggacgag agcggcgagc
     4741 ggcgtggtgg gcgcgccagg agaccagtag tgcgcccgcg ccagcacggt cccgtcggct
     4801 cccatcagct tgttcgctgc tgaaaatgcc gaacaccggt ggcaggaata tgtcagcgcc
     4861 accggtgatc ctctcattat cgctcggcgg ggatcggcgt ccttcatttc cgaacgaccc
     4921 gtgtgacgaa cgattttcag gtatgggcac ctgaaaccgc tcagggcgcg tcatccgcag
     4981 accacgtaga ggagaagacc gtgatcgtcc gtacgattgc tgagatcaac gaaaccgaag
     5041 ccgatgtcaa aactgcgaac tggcgcagca agcggctgat cctcgcgggg gacaaggttg
     5101 gtttctcgat gcacgagacc acgctctacg cgggaacggt caaccagttc tggtacgcga
     5161 atcacgtcga ggccgtgttc gtggtcgaag gcgaggggga acttgtcgac agcgccacgg
     5221 gagaggtctt ccagttgcgt cccggaacca tgtacctact gaacaaccag gacaagcacg
     5281 aggtccgtcc cacgacggac gtccgggctg tctgcgtctt caaccccccg gtgaccgggc
     5341 gggaggtgca cgatgagaac ggtgtctacc cgctcatcac ggaagcggat tagacactcg
     5401 cgatacgccc actcgctgac cgtgtatacg catcttaata cgcggtaaag agccttgtgt
     5461 ttgctggtca gtggcttccc gagaaccgtg gatgacgaac tgcggttcgg gtacgggaga
     5521 gtcgcggtcg tggggaggta ggtcccaacc tccgattttc ccccacggcc gcgactctcg
     5581 cttgcagccg attgttgaca atgggcgcgc agggccgtag cttccctcgt cattcaggcg
     5641 acatccgaag ggaaagctga atgctcatat ggctgcaaca aaagctcggc ctacgaacaa
     5701 accccacgat cttctttgtt tccgcaatac tgacggtcgc gttcgtcgcg atttcgattc
     5761 tcttcaccga taccgttgac gcgactttca aggcgctgtc ggagttcatc acgacaaacc
     5821 ttggttggac gtatattttc ggtgtcacat cttttctggt gttcttgatc tggatcgcat
     5881 gtggccgata ccgccatgtt cgcctgggtg gaaaagactc ccggccggag tacggcaacg
     5941 tcacctggtt cggcatgctg ttcgctgccg gaatcggcac cattctcatg ttctggggcg
     6001 tcgccgagcc gatcaatcac tacgccaacc cgccgcagtc cggaattcag cccgaggtgc
     6061 tcgaaggact cagcgccgag gagatcgcgc aggtggaggt tccctccggc gcggcggcgc
     6121 cgctcagcaa cgcggcaggc gaggaggcga tgggattcac gctgtaccac ttcggtctgc
     6181 acacctgggc gatcttcgcg cttcccgcgt tggccttcgc ctacttcgcg taccgccgga
     6241 agctgccgtt ccgggtgagt tccatcttcc agccgctgct gggcgaccgc atcaacggtc
     6301 ccatcgggaa gatcatcgac atcaccgcgg tgctgggaac cctgttcggc gtcgctgtct
     6361 cgatcgggct cggtaccctg cagatcaact ccggccttgg tgcgctgttc ggcatcgagc
     6421 aaggccggac agcccaggtc gtcatcatcg ctgtggtgac ggtcgtcgcg gtcatctcgg
     6481 tcgcgctcgg gctggacaag gggatcaagc ggctctccaa catcaatatc gggcttgcgg
     6541 tcgcattgct ggtcttcgtg ctgatcgcgg gctcgacggt gtacctgctg cggggagtca
     6601 tcgagacggt cggaacgtac ctgacgcacc tcgtgcccct gtcgttctgg aacgacgcgt
     6661 tctccggtga caactggggc tggcagggcg gctggacggt gttctactgg gcctggacga
     6721 tcacctgggc gccgttcgtg gggattttca tcgcccggat ctccaagggg cgcacgatca
     6781 gggagttcgt catcggtgtg ctgggcgccc cggtcgcgtt cagcatcgtg tggttcagcg
     6841 tcttcgggat gtccgccatg cggatcgaga gcggcgatcc ggggaagctg gtcgagccgg
     6901 tcgtgcagga cggcgacacg gccggggcct tgttcgcgtt tctcgacagt ttcccggcca
     6961 ccgagttcgt catggcggtc gcggtgctga tagtcgtggt cttcttcacg acgtcctcgg
     7021 actcggcgtc gctggtgata gacatgctgt gttcagggcg cgagtggaat ccgccgacga
     7081 ggcaacgtgt cttttgggcg gtactgcagg gagtggtcgc ggcgacgctg atcgccgcta
     7141 cgggacgtga ggcattggat gcgctctccc aggtcataac cgtgctcggg ctcccattct
     7201 ttgtcatcgc attcctgatg atgttctgtc tggtgaaggc attgagagag gatgtgacag
     7261 acgaggaact gctcccgtcg ccgcgcaagt tgcggagcaa agaagtgccg gtaatcaaat
     7321 cctcggcaaa cgaggacagt gaggttctca cgtagtacga gatcgaggcc gccgcccgga
     7381 atgtgccggg cggcggcctc gattcacgtc agcagtcgac gcgggacatc ctgaagagag
     7441 cattaacgaa cgtgctcggt tcgctgaagg aagccggtga gctccacgta ggcggatacg
     7501 gttctgcaca tgttgacgac aggacttggt ttggacgagg tggcgacgct tccggccggc
     7561 ctgcgcgagg agatcggcag aatcgcgcgc acgccacgcc tcctcgtcgg gtgtgactac
     7621 gacggcactc tcgcgccctt cgtgtcggat cctgacgcgg ccaagccgtt ggccgagtcc
     7681 gtggcggccc tgcgcggtct tgccgccctg cacgagacca gcgctgtggt gatctccggg
     7741 cgggcactgc gggacctcgc cacgctctcc cggttgcccg ccgaggtcca gctcgtcgga
     7801 agtcacggtt cggagttcga cgccggcttc gttcgtcaac tggatcgcgg cgccctgagc
     7861 cacaagcagg agttgcacga gcggctcaaa cagctcatcc aggacagaac aggggtcacg
     7921 ctcgaggtca agcctgccgg cttcgccgtg catgtccgca atgcggaccg acacaccgca
     7981 cagcggaccc ttgacgaggt ccggggcgcc gagttcgccg gagtgcaggt ggtcgagggc
     8041 aacgaggtcg tcgagctcac cgttgtcccc acggacaagg gacgcgcgct ggactccgtg
     8101 cgcagggaca gtgcggccac cgccaccgtc ttcatcgggg acggtccttc ggacgagaac
     8161 gcgttcggca ggctcgcttc cggtgatctg tccgtgaagg tcggtccagg tgacacgatc
     8221 gccgactacc ggctgcgcga ccccaaggat gtagctctcg ctctcgcgct gctcaaggag
     8281 caacgacatg cctggctgca cggggaacag gcgacaccga tcgagcggca ctccatgctg
     8341 gccaacgagc gttcgatcgc gctggtcact ccggacggcg cggtgagctg gatgtgctat
     8401 ccggaacctg attcctcggc gttgttcgcg cagctgctcg ggggcaccac ggcaggccac
     8461 ttcacggtgt cccccgcgcg caccggcctg ccgctcggac agcgttacct ccccggcacg
     8521 atgacggtcg agacccgctg gtccggtctg cgggtgacgg actacctgga ccatgcgggc
     8581 tccgatttcc gcacggatct cattcgggtg atcaccggcg atgttccggc cgtggttcag
     8641 ttcgcgcccc ggccggagtt cggacagatc ccggtgaagc tggtcccgga cggggattgt
     8701 ctgcgggtcg tcgggacatc ggatccgatc accttgtacg cgccgggggt ccgctggtcg
     8761 atcgaccagg atggtccaca tgagaccgcg cgtgccgtgg tgaaccccgc gggcaaggct
     8821 tcggtggtac tcgagcttcg gtgcggttcc accagcgccc gcccgcacta cctgccggag
     8881 ccgacccggc gggcgctggc gggcgcctac tgggtgtcct ggctcaacga ccggcgactg
     8941 cctcaggtcg agcggtccct ggttgcccgg tcggcgctga cgttgcgcgg actgtgccac
     9001 gacacaacgg gtgcgatcct ggccgcggcg accacctccc ttcccgagga gatcggtggt
     9061 atccggaact gggactaccg ctactgctgg atccgggatg ccgccatcac cgcccggtgc
     9121 atggtttcgc tgggatcggt gaagcccgcc gaacgattcc tcggctggct gggcaggatt
     9181 ctcgcggagc tcccggggcc ggaacgtctt catccgctgt acaccctcgg tggagccacg
     9241 ctcggaccgg aggcggtgat cgagaccctg cccggctatg ccggttcccg tccggtgcgc
     9301 gtcggcaacc ttgccggcca gcaggtccag ctggacgtgt tcggcccggt cgtcgaactg
     9361 atcaccgacc tcggcgcgga acggggttgg ctgtcggagg aggagtgggc actggtgacc
     9421 cagatggtcg aggcggtcga ccgccgctgg caggaaccgg accacggaat ttgggaagag
     9481 cggattcgtc cgcgccacca cgtgtatacc aaggtcatgt gctgggtggc cgttgatcgt
     9541 gcgttgcggt tggccgagac attgggcaag ccccatcggg aaaggtgggc cgagctgcgt
     9601 gcggcgatcg ccaccgatgt cctcgaacac gggtggaacg ccgaagtagg ctccttcacc
     9661 accgcgtacg acggtgacga cctcgacgcc gcgacgctcc acatcgggct ttccgggctc
     9721 cttgatccgg aggacccgcg cttccacgcg accgtgctcg cgacagaggc gcagctgcgg
     9781 tacggatcca ctgtgtaccg ttatcgacga gacgacggcc tgccgggcaa ggagggcggc
     9841 tttcacttct gcacggcgtg gttggtggag gcctacctgc tgaccggtcg ccgacttgaa
     9901 gctgaggaac tgttcaagca cctggtggac tcggcgggac cgaccggcct gctgcccgag
     9961 gagtacgacc cggtcgccga gcgatcactt ggcaaccatc cgcaggcgta ctcccacgtc
    10021 ggactcatcc gctgcgcaca gttgctgtcc gggtgactga tgctcgcgtg atgccagcgg
    10081 gcatggacga ggcgggagag cgtcacggca ccgcgtgatc ggtccactcc cggcgtgttc
    10141 gcttcccgag ccgccaggct cgtggcgcct cgctcgtcgc gcggcgtccg gcttcgggga
    10201 accggagccg gacgcgcgcg ccgcccagcg agctctgctc gagatggatc gacccaccga
    10261 tctcctccac gcacgtccgc gcgatgtcca ggccgagtcc ggtcgacccg gctccactgg
    10321 atccacgtcg tagagccgcc tcgggatcgg cgatgccctt accgccgtcg tcgacgacca
    10381 aggtcaccca gtt
//
