LOCUS       NZ_FOKG01000010        22534 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Amycolatopsis marina strain CGMCC 4.3568, whole genome shotgun
            sequence.
ACCESSION   NZ_FOKG01000010
VERSION     NZ_FOKG01000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis marina
  ORGANISM  Amycolatopsis marina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900111885.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:41:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,708
            CDSs (total)                      :: 6,643
            Genes (coding)                    :: 6,572
            CDSs (with protein)               :: 6,572
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2, 5 (16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 22 of 71
            Pseudo Genes (incomplete)         :: 62 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 15 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:06:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 14484
            Orig. end                         :: 37018
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOKG01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22534
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="thioamitides"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and TfuA)"
                     /tool="antismash"
     cand_cluster    1..22534
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and TfuA)"
                     /kind="single"
                     /product="thioamitides"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22534
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12534](-)"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and TfuA)"
                     /neighbourhood="10000"
                     /product="thioamitides"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12534)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and TfuA)"
                     /neighbourhood="10000"
                     /product="thioamitides"
                     /protocluster_number="1"
     gene            complement(391..1614)
                     /gene="rocD"
                     /locus_tag="BM199_RS17410"
                     /old_locus_tag="SAMN05216266_11023"
     CDS             complement(391..1614)
                     /EC_number="2.6.1.13"
                     /GO_function="GO:0004587 - ornithine aminotransferase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (33-354). E-value: 1.4e-101.
                     Score: 331.8. Matches aSDomain:
                     nrpspksdomains_BM199_RS17410_Aminotran_3.1"
                     /codon_start=1
                     /gene="rocD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645160.1"
                     /locus_tag="BM199_RS17410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11023"
                     /product="ornithine--oxo-acid transaminase"
                     /protein_id="WP_091674313.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.5e-119, bitscore:
                     393.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTFADSTTRTASDFIALDEQWSTHNYHPLPVVIAEAEGAWVTDV
                     HGERYLDFLSGYSALNFGHRHPALVEAAVAQLGRVTLTSRAFHHDQLGLFCRELAQLTG
                     TELVLPMNSGAEAVESAIKVARKWAYQVKGVPQGEAEIVVAGSNFHGRTTTIVSFSTDD
                     TARADFGPFTPGFKVVKYGDADALTSAITERTAAVLLEPIQGEAGVVVPPDGYLAEARR
                     LCDEAGALLIADEIQSGLARTGTVFALDHERIRADLYTLGKALGGGIMPLSAVAGRRDV
                     LGVLRPGEHGSTFGGNPLACAVGRAVIALLETGEFQQRSAALGAHLHNRLGELVGNGLA
                     EVRGRGLWAGIDIAPGGPTGREASQALAAKGVLCKETHDNTLRLAPPLVISEEELDSGL
                     DAIAEVIR"
     aSDomain        complement(553..1515)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM199_RS17410_Aminotran_3.1"
                     /evalue="1.40E-101"
                     /label="BM199_RS17410_Aminotran_3.1"
                     /locus_tag="BM199_RS17410"
                     /protein_end="354"
                     /protein_start="33"
                     /score="331.8"
                     /tool="antismash"
                     /translation="IAEAEGAWVTDVHGERYLDFLSGYSALNFGHRHPALVEAAVAQLG
                     RVTLTSRAFHHDQLGLFCRELAQLTGTELVLPMNSGAEAVESAIKVARKWAYQVKGVPQ
                     GEAEIVVAGSNFHGRTTTIVSFSTDDTARADFGPFTPGFKVVKYGDADALTSAITERTA
                     AVLLEPIQGEAGVVVPPDGYLAEARRLCDEAGALLIADEIQSGLARTGTVFALDHERIR
                     ADLYTLGKALGGGIMPLSAVAGRRDVLGVLRPGEHGSTFGGNPLACAVGRAVIALLETG
                     EFQQRSAALGAHLHNRLGELVGNGLAEVRGRGLWAGIDIA"
     gene            1639..1938
                     /locus_tag="BM199_RS34945"
     CDS             1639..1938
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013209.4"
                     /locus_tag="BM199_RS34945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ArsR family transcriptional regulator"
                     /protein_id="WP_091674314.1"
                     /transl_table=11
                     /translation="MWFIRDTLLVACVRCVVLAGVRRIVAYPLTFGVVSRPAVSQHLKV
                     LKDCGLVTDHVRGTRRMYRLRLEGVAGLRAYRDEMWTEALTAFAAAEQDGDDDE"
     gene            2108..4195
                     /locus_tag="BM199_RS17420"
                     /old_locus_tag="SAMN05216266_11026"
     CDS             2108..4195
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419978.1"
                     /locus_tag="BM199_RS17420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11026"
                     /product="S9 family peptidase"
                     /protein_id="WP_091674315.1"
                     /sec_met_domain="PF00561 (E-value: 5e-07, bitscore: 23.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.2e-50, bitscore:
                     164.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDDLSFLRKQARTQRFTLGAPKEFRVSPDGDRVLFLRAESGVDR
                     RHSLWSQDLASGVESKIVDAVALLPGEEELPPEERARRERTRNASGGVVGYATDSGLTM
                     AAFSLSGKLYTADLRSGDVTLRVDDSVVDPRPNAAGTHVAYVRDRRLRVLDLAAGTDRM
                     LVDEPGEDIAWGLAEFIAAEEMGRARGYWWAPDGQSLLVERTDRAAVPRWTIADPANPG
                     LPPNTVSYPAAGTVNVDVSLAFLGLDGTRVDVQRGDWEYLAAVHWSAGGAPLLAVQPRD
                     QRRLEVHEVNPADGSTKLLHTETDPHWVEIVQGVPAWTSDGRLVRVSAADGNYRLLIDG
                     EPVTEPGMQLRSVLDVGEEVLFSASEDDPTQIHVYRTDGGKVQRLSTEDGVHIGGGNAA
                     LTVLSSWSMSRSGPKVSVLRDGKPVAGIASYTVDPGTAPKVAMLTVGERGLRAALLLPT
                     GHRAGSAKLPVLLDPYGGPHAQRVLQSRNAFLTAQWLADQGFAVLITDGRGSPGRGPEW
                     EREIAGKLAEVPLADQVDALHAVAAEYPDLDLDRVAIRGWSYGGYLSALAVLRRPDVFH
                     AAVAGAPVTDWSLYDTHYTERYLGTPQDEPDSYRRNSLIADAPELRGALLLVHGLADDN
                     VFVAHALRLSSALLAAGRPHTFLPLAGGTHMTPQAEEVAENMMRLQIDWIKRELDARVG
                     H"
     gene            4236..5189
                     /locus_tag="BM199_RS17425"
                     /old_locus_tag="SAMN05216266_11027"
     CDS             4236..5189
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645165.1"
                     /locus_tag="BM199_RS17425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11027"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_091674316.1"
                     /transl_table=11
                     /translation="MKRWGITIPLTGVPLAEHRELIEQLPDLGYTDAWSAETAGTDAFS
                     PLLLASQWAPQLRLGTAIVPVYTRGPGLLAMSAATLAECAPGRFVLGIGTSSPVIVENW
                     NAAEFAEPFGRSRDTLRFLRAALAGEKVTEQYPTFSVSKFRLERAPEPAPPIMLAALRP
                     GMLRLAAREADGAITNWLAPGDVPTVRAEVGPDVELVARVFVCPTEDADAARGLGRMLI
                     SSYLTVPVYKAFHEWLGRGDALAPMHEAWQAGDRKRAGELIPDDVVDDLIVHGSVDECR
                     DKVQSYVDNGLNTPVMALLPTGDNPFEHIKGLAPRS"
     gene            complement(5211..5585)
                     /gene="crcB"
                     /locus_tag="BM199_RS17430"
                     /old_locus_tag="SAMN05216266_11028"
     CDS             complement(5211..5585)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:1903425 - fluoride transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:1903424 - fluoride transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crcB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009944492.1"
                     /locus_tag="BM199_RS17430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11028"
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="WP_091674317.1"
                     /transl_table=11
                     /translation="MTALLVAVGGALGAILRYLVDQRVRRSHRTLFPWGTLVANMTGSA
                     LLGVLAGWALAGGQPDTVRALVGVGLCGSLTTFSTFGYETVRLVSERARLHAVANVVVT
                     VLAGFGAAATGLVAANAIWG"
     gene            complement(5582..6013)
                     /locus_tag="BM199_RS17435"
                     /old_locus_tag="SAMN05216266_11029"
     CDS             complement(5582..6013)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224560.1"
                     /locus_tag="BM199_RS17435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11029"
                     /product="CrcB family protein"
                     /protein_id="WP_091674318.1"
                     /transl_table=11
                     /translation="MGRRVGEPHRWTVLLAVAVGGALGSLARYGLGLALPHERGQFGTA
                     TLLANIGGCLLIGVLMMLIITIRDPHPLLRPFAGIGVLGGFTTFSTFVVEAMDSALTGR
                     PGLALLYAAVSVLASLLAVALGMRATRVAVTHVRRGATP"
     gene            6232..8187
                     /locus_tag="BM199_RS17440"
                     /old_locus_tag="SAMN05216266_11030"
     CDS             6232..8187
                     /EC_number="4.2.1.3"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948527.1"
                     /locus_tag="BM199_RS17440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11030"
                     /product="aconitate hydratase"
                     /protein_id="WP_091674319.1"
                     /transl_table=11
                     /translation="MGHGVAEQLISEHLVSGEMTPGAEIALRVDQTLTQDATGTLVMQE
                     LEAMNLDRARTEVSVQYVDHNLLQADEKNAEDHAYLRSACRRYGLWFSKAGNGVSHPTH
                     MQRFGIPGKLMVGSDSHTCAGGSLGMLAIGVGGLEVAMAIAGTPLYLQMPRIWGVRLTG
                     ELPPWVSAKDVVLEMLRRHGVKGGLNRIIEYHGPGLAQLSAMDRHVIANMGAELGATTT
                     VFPADEAVREFLRAEDREEDFREVLPAEDARFDDTDEIDLSTLEPLIAKPSSPGNVVPV
                     REVAGADVGQVVIGSSANPGLRDYAIAAHMVRGRQTEDSVSFDVNPSSREIFADLTKMG
                     ATFELISAGARIHQAGCMGCIGMGQAPAVGHNSLRTFPRNFPGRSGTKEDAVWLCSPET
                     ATAAALTGVIADPREVAERLGIEYVRPEMPSRASVNTDMLVPPLEPGEAEREELVKGPN
                     ISALPDFPPLPDRIEAPVLLKVPDDISTDEISPAGARALPFRSNIPMLSEFTFSQVDET
                     YPQRAREVADGPGHLIVGGDNYGQGSSREHAAITPRHLGLRAVIAKSFARIHWQNLANF
                     GILALEFVDPADYERIDQGDTLELESLREGLSESPELTARNVTKDEQYRLHHRLSERQV
                     EAVMAGGRIPLLASMV"
     tRNA            8298..8371
                     /anticodon=(pos:22816..22818,aa:Pro,seq:ggg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="BM199_RS17445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="SAMN05216266_11031"
                     /product="tRNA-Pro"
     gene            8298..8371
                     /locus_tag="BM199_RS17445"
                     /old_locus_tag="SAMN05216266_11031"
     gene            8664..9173
                     /locus_tag="BM199_RS17450"
                     /old_locus_tag="SAMN05216266_11032"
     CDS             8664..9173
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018681558.1"
                     /locus_tag="BM199_RS17450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11032"
                     /product="quercetin 2,3-dioxygenase"
                     /protein_id="WP_091674320.1"
                     /transl_table=11
                     /translation="MHAPFQTTSADARALWHMGALLRLKATGEDTAGQFSLTEHTCRQG
                     TASPLHRHTREDEAFLVLEGELRIYIDGRHYHAQAGSLTFAPRGLPHAYRATSPTCRFL
                     ALITPGGFEQWFAETGEPALSPNLPPAPSGPVDTTRLISAAARYGVEVLGPSPIVDDAT
                     THADPR"
     misc_feature    8727..8729
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9185..9949
                     /locus_tag="BM199_RS17455"
                     /old_locus_tag="SAMN05216266_11033"
     CDS             9185..9949
                     /NRPS_PKS="Domain: PKS_KR (8-188). E-value: 2.3e-10. Score:
                     32.6. Matches aSDomain:
                     nrpspksdomains_BM199_RS17455_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466335.1"
                     /locus_tag="BM199_RS17455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11033"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_091674321.1"
                     /sec_met_domain="adh_short (E-value: 1.4e-31, bitscore:
                     103.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTTRGAVTALVTGASAGIGRATAVAYGATGAQVGITYRKDRAAA
                     EETARQVRSVGGQALPVALDLGDPSGIAAAVATVQGWAGDIDVLVNNAYDAGEWTPGTD
                     TAFEDIPVGQWQHILRQNLEGAFHVVRAVLPGMRRREAGRMVLISSGAVEHGSTGTGPY
                     AAAKAGLHGLCRSLAAELGPAGILVNVVMPGITTTERALRSLPPSLVDAVTDATPTRRL
                     STPDDVAQSILFLGSTANGNITGQVVRVTGGQ"
     aSDomain        9209..9748
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM199_RS17455_PKS_KR.1"
                     /evalue="2.30E-10"
                     /label="BM199_RS17455_PKS_KR.1"
                     /locus_tag="BM199_RS17455"
                     /protein_end="188"
                     /protein_start="8"
                     /score="32.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TALVTGASAGIGRATAVAYGATGAQVGITYRKDRAAAEETARQVR
                     SVGGQALPVALDLGDPSGIAAAVATVQGWAGDIDVLVNNAYDAGEWTPGTDTAFEDIPV
                     GQWQHILRQNLEGAFHVVRAVLPGMRRREAGRMVLISSGAVEHGSTGTGPYAAAKAGLH
                     GLCRSLAAELGPAGILV"
     gene            complement(10001..11344)
                     /locus_tag="BM199_RS17460"
                     /old_locus_tag="SAMN05216266_11034"
     CDS             complement(10001..11344)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thioamitides: TfuA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF019429.4"
                     /locus_tag="BM199_RS17460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11034"
                     /product="TfuA-like protein"
                     /protein_id="WP_091674322.1"
                     /sec_met_domain="TfuA (E-value: 5.1e-37, bitscore: 120.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIHVFAGPSLSGSSVLDLDGVCAHPPIAHGDLYRLRPGTDDSVL
                     IVDGVYQHTAPVRHKEILDLYAAGVPIYGAASLGALRACEHQDHGMTGLGTVFAWYRDG
                     RLISDADVALTHGDADVGFRAFTHALVSIIGVTDRLAAAGHLDPTAASRVVELARSLHF
                     SIRTNAALLASAGEQQLADSVRLVVDELRNDRLGDIKRIDAESAIHDLLAGRVLAPSAG
                     EIEVPLTTYHKEWRLQHTPATADIDGPTRRQLLAYAQLFLPDFPDRHTAHVLANLRPEY
                     PEVGLAAYGSSPATGYDVFLPPWLDALSADELVRRGILARGELETLDEHDRAIRVLVRT
                     FRRRSGRLVYDEVPPELDPDMTELTQQSARLLRLNSQAMRRNPKFHPGDIPTDLIDAKF
                     AELWRTDELPTHVLDRGFRSLEEFREQARPYFIAARAFVAMRDEPLKV"
     gene            complement(11341..12534)
                     /locus_tag="BM199_RS17465"
                     /old_locus_tag="SAMN05216266_11035"
     CDS             complement(11341..12534)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thioamitides: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="BM199_RS17465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11035"
                     /product="YcaO-like family protein"
                     /protein_id="WP_177242664.1"
                     /sec_met_domain="YcaO (E-value: 4.1e-53, bitscore: 175.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDRSPEDTWEFVRPRMREYGVTRIAELTGLDIIGMPVYMAVRPL
                     ATTVGVSQGKGATPLLARLSAVMEAIEMSVCERYFTTPDAFVAQAVELDLPYATSETTP
                     TERSIISDRFPLRWVPAVSLADGEPTFVPLRSVAMDGVSDGTWRPSTQFCSANGLASGN
                     TLAEATIHALLEVIERYSTAGVAKTPIRQRKVLDLRTLPDCWSRDLVEHLHDIDFWVEV
                     VDCSVVPGVSAFAVFLWHPDMPSLYAGSGSHFLPEIAVQRALTEAVQSRMSVISGTRED
                     IGSVSYRGVRRPVPPLPVEPNHSWNAIPTPPVDASVPSADMLAWLVDQVSVMSGRPVLR
                     VDMTPPGEPFAVCKVVAPGLPELLHEANEELPRHPDPEDTQPRPTSTHPHDSGEGAS"
     gene            complement(12647..14116)
                     /locus_tag="BM199_RS17470"
                     /old_locus_tag="SAMN05216266_11036"
     CDS             complement(12647..14116)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="BM199_RS17470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11036"
                     /product="MFS transporter"
                     /protein_id="WP_143101844.1"
                     /transl_table=11
                     /translation="MTSSRPPTRRWLALALLAMTQFVLVVDTAIVIIAAPSMEADLGFT
                     PEGLSWVANAYALAFGGLLLLGGRAGDIVGRRRMFIWGLSLFAVGSLAGALATSPLWLI
                     IARAVQGMGAAAVSPAALALVMTLFTEQKERNKALGIWGSVAATGAATGYVFGGLLTEW
                     FGWQAVFWVNLPIVAVVVLLAPQLLPETKDAVHRSFDIAGAVTVTGGVSLAVYALINAA
                     HVGWASAQTLGLFTAAAALLAAFVAIEARSSQPLISLKIFRIASLRNGNGLTLLTMGAM
                     TPMFFFLTLYLQHVLGFTPIQAGLAQMPAAVCFALLGTHVGKLVSRIGYRIPATVGGLI
                     AGAGMFWLAQVEVNGNYFTDVMAPLTMTALGATLGVISLMIAATAEAPLDSAGLAAGLV
                     NVTQQIGGAVGLAVLSTVAATANSRATERGGDTLSSFTDGVSTALTVGAGIAVAAGVLA
                     PVLLRKARRGTAAPDDSATTLAENEVAAAGH"
     misc_feature    14154..14169
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.99"
                     /tool="antismash"
     gene            14306..15958
                     /locus_tag="BM199_RS17475"
                     /old_locus_tag="SAMN05216266_11037"
     CDS             14306..15958
                     /NRPS_PKS="Domain: AMP-binding (10-416). E-value: 3.4e-85.
                     Score: 278.0. Matches aSDomain:
                     nrpspksdomains_BM199_RS17475_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164929.1"
                     /locus_tag="BM199_RS17475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11037"
                     /product="AMP-dependent synthetase/ligase"
                     /protein_id="WP_091674325.1"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-85, bitscore:
                     280.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRPRTFPEAFQRTVAAHPEDVALRTPDDSIRLTWKEYGDEVRRI
                     ASGLASLGVKRGDTFAAMLTNRPEFNLTEVAASHLGATTYSIYNTSSPEQINYLLTHAG
                     TKVVVCDRQFAGRIKASGAPLEHLLVVEDGDLDRLRPASGFEFEATWRAVEPDDLLCLI
                     YTSGTTGPPKGVEHTHRGWLRMIDSIATIWPLEAGDTAISYLPSSHSGDRFFRHYYAIA
                     RGAQVISVADASRLTEAIAEVHPTTFAAVPRTWEKLKAHLERELLTDEKAAAAFAAGEP
                     RLLDAIRVKIGFDRLKWALTGTAAIPEHVYAFWQKLGVPVTVGWGMSECGFGAGSSPSG
                     SRIGTIGTIAPGAEARLSQDGELLVRMPWMMRGYRKDPTKTAEALDPDGWLHTGDLAET
                     DDDGNYRIIGRKKELIVNSGGKNMSPSNIEHAIAEGTSLMGPAMAVGDDKPYNVALITL
                     DPDAAVAFASKVGVAADPVILAKDEQVLEKIRASVYAGNQKLSRIEQIKKFTVLPTFWE
                     AGGEELTSTMKLKRRSIAEKYADEIDALYASTT"
     aSDomain        14336..15553
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM199_RS17475_AMP-binding.1"
                     /evalue="3.40E-85"
                     /label="BM199_RS17475_AMP-binding.1"
                     /locus_tag="BM199_RS17475"
                     /protein_end="416"
                     /protein_start="10"
                     /score="278.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FQRTVAAHPEDVALRTPDDSIRLTWKEYGDEVRRIASGLASLGVK
                     RGDTFAAMLTNRPEFNLTEVAASHLGATTYSIYNTSSPEQINYLLTHAGTKVVVCDRQF
                     AGRIKASGAPLEHLLVVEDGDLDRLRPASGFEFEATWRAVEPDDLLCLIYTSGTTGPPK
                     GVEHTHRGWLRMIDSIATIWPLEAGDTAISYLPSSHSGDRFFRHYYAIARGAQVISVAD
                     ASRLTEAIAEVHPTTFAAVPRTWEKLKAHLERELLTDEKAAAAFAAGEPRLLDAIRVKI
                     GFDRLKWALTGTAAIPEHVYAFWQKLGVPVTVGWGMSECGFGAGSSPSGSRIGTIGTIA
                     PGAEARLSQDGELLVRMPWMMRGYRKDPTKTAEALDPDGWLHTGDLAETDDDGNYRIIG
                     RKKELIV"
     CDS_motif       14786..14842
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BM199_RS17475_0001"
                     /evalue="1.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="BM199_RS17475"
                     /protein_end="179"
                     /protein_start="160"
                     /score="24.2"
                     /tool="antismash"
                     /translation="CLIYTSGTTGPPKGVEHTH"
     CDS_motif       15386..15457
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BM199_RS17475_0002"
                     /evalue="1.50E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="BM199_RS17475"
                     /protein_end="384"
                     /protein_start="360"
                     /score="11.0"
                     /tool="antismash"
                     /translation="GELLVRMPWMMRGYRKDPTKTAEA"
     misc_feature    15392..15394
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16190..16312
                     /locus_tag="BM199_RS34950"
     CDS             16190..16312
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS34950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_281245712.1"
                     /transl_table=11
                     /translation="MIDIAQISDNELLTAAGATSVDFSDAATAPSVMAGEPCDS"
     gene            16441..17046
                     /locus_tag="BM199_RS17480"
                     /old_locus_tag="SAMN05216266_11039"
     CDS             16441..17046
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014494.4"
                     /locus_tag="BM199_RS17480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11039"
                     /product="flavoprotein"
                     /protein_id="WP_091674326.1"
                     /sec_met_domain="Flavoprotein (E-value: 2.8e-26, bitscore:
                     85.7, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRNSTNDEPRTQVQSSSGQIMTAMPLGSLLIGVCGSSAAESTGE
                     LAEEALRYANDITVVATRTAAALFVSDLPVPLYTDADWIDKPLHVTLLQQADTLVIAPA
                     TATTLAKAAAGIADTLVTALICAHGPGVYFQPCMNARMWTSPAVRRAVDTLRGDGHHVL
                     EPGPVASRASRTVGSGVGEIPGNVLATVAEHKRESGRN"
     gene            17151..17552
                     /locus_tag="BM199_RS17485"
                     /old_locus_tag="SAMN05216266_11040"
     CDS             17151..17552
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019498.4"
                     /locus_tag="BM199_RS17485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11040"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_091674327.1"
                     /transl_table=11
                     /translation="MPKVSWDSASKIEEVGPVRDRFEILDGYSANFTVFDEDIDATSLL
                     KGLPEDRCQCPHWGYVIKGRMTVRLGDQEEVYEAGDAFYTPPGHVPLKHQAHTEVIMFS
                     PEEELRRTGAAVAQNAEAEGMHVRRPEQQ"
     gene            17618..18565
                     /locus_tag="BM199_RS17490"
                     /old_locus_tag="SAMN05216266_11041"
     CDS             17618..18565
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019604.4"
                     /locus_tag="BM199_RS17490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11041"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_091674328.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 8.8e-31, bitscore:
                     100.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDVIVIGGGPAGLSAALTLGRALRPTLLIDSGEYRNAPAADMHN
                     FLTRDGTPPSEFRKISHSELDQYSTVEIRNVTVDDTRPLKDGDGFELTLTDGSAVQARR
                     LLLATGLADDLPPIEGIGELWGRGVYHCPYCHGFEIRDTPIAVLYSDPLMVDLALHLRR
                     FSSDVVLCADGRGDELDGSTLARLADNGVAVRGEKVVRLESNGERLENVVFESGESLPR
                     HGLFAMSQFRQRSELPGRLGCQLLPDGCVAVDDFQLTSVPGVYAAGDMAHRASLPMPTP
                     FVSTATSSGTIAAIAADKNLVATDTTTRPDPVPA"
     gene            18661..19227
                     /locus_tag="BM199_RS17495"
                     /old_locus_tag="SAMN05216266_11042"
     CDS             18661..19227
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS17495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_11042"
                     /product="hypothetical protein"
                     /protein_id="WP_091674329.1"
                     /transl_table=11
                     /translation="MNATVAVALITSLSTLAAAALTGMVSAWSNGRQLRHQRLLAREQQ
                     AEERGAQRRELRREAYQQFLSQADAAYRVLDEGWLAAPFAGSSRWEAGFTARRGLDEAY
                     IRVQLEGPDRVAAEGANVVRSIGDEFRTHRRVLDANPGTQDCAAELDRAARADVLRARF
                     RTSKDFVAAARDSLGDEPPRELPEA"
     gene            19387..22437
                     /locus_tag="BM199_RS17500"
                     /old_locus_tag="SAMN05216266_11043"
     CDS             19387..22437
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012471.4"
                     /locus_tag="BM199_RS17500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_11043"
                     /product="M14 family metallopeptidase"
                     /protein_id="WP_091674330.1"
                     /transl_table=11
                     /translation="MRRRYVVVLLAAALVGGSATTGSAAPAPPAGAEGDLRAYAAELAP
                     AEVHDLRAEGIDVLDVPGGGVELILTDQQRERLRSTGIELRPKEPAARTRSAPETAADG
                     VYRPYSGPGGIEEEIRRTVADNPHLAKLVPIGETRQGREILAVKLTLGARFLPDGAKPA
                     SLYSSTQHAREWITVETNRRLMHHMIDNYGSDREITRLLNRNEYWFVLVVNPDGYDHTF
                     TEGNRLWRKNLRDNDGDGAITVNDGVDLNRNFDYTWGYDNEGSSPNPTSQTYRGPAPNS
                     EPETRALDDLFRKVDFSFLVNYHSAAQLLLYGVGWQVNTDSPDDLIAKTLAGTDAKPGV
                     DGFDPDVSAELYTTNGETTNHAQARYGIISFTPEQTTCQAASRSDPNDEWRPEDCQSGF
                     NFPDDEELIQEEFERNLPFALDIARSTADPANPKSHLGNTAPEIVAKPVSTSFGETQTV
                     SAIAKRRPGPVLVRYRINDGRTRIAFAREWDGGERYGDGFDVHYEEVRADLRGAGPGDR
                     VEVVFQSHGKRTEPFTYTVERTAAKPVLVLANEDYEGFDPPVPNAVPQAPGPRHLDAYT
                     AALEANDIPYDVWDMTQRGAPDPLGVLAHYEAVVWYTGDNVVTQREPGAGDNIVAKVQQ
                     DTTLAVRDFLNEGGKLLHTGEYAGYFGPNGSLFFDNAEEPCAPESSSFRLCVFSNDFYQ
                     YYLGGFSRSSVNSPDEVTGTGRPLAGNLSLVGGDGAGNQERPGEFRVTGDVLPEEDFPQ
                     FRSSEAARYVPTGPEPEQPLSGEWYAGALHDDQSYQRLTRTIDLSSAGAASLGLNLSYD
                     LETGYDFVMVEARVVGTDGWTTLADAEGRATSTVPTQCEQGFLLALHPWLERYLTVDGD
                     SCLPSGTSGSWNGFTGSSGWGPATFDLSRYAGEQVEVAVSYVTDPSSGEVGAFLDDTSV
                     TVDGQVAEESGFEDGLGPWAIAPPPEGSADTGAAWQRSRSLVQPRAAAVTTEDSVYLGF
                     GLESLATAEQRAKVLGDALRHLLEPAT"
ORIGIN
        1 tcacccagcc cgaactggat gaagcctatg cgctgtacga cgcgccggag ttcctcgact
       61 actgctggct gaccgtcgcc gcatggggtc agcgacccgg ctgagcacgg accgtcggtc
      121 cccctatcgg gatggtgtgg gtgttcggcg cgcttggcgt tgacgcggta tgtccggacc
      181 gcgtcggctg ggtgggcggt gtgcggtgtt gcgcaggtcc cggtggtggc gagcgcagac
      241 gaggatcatg ttgttcagtc ggacagtcca tcgtcgatcc accccaaccg cactttcccg
      301 gaaaagtgca gacctgaaga tcgcactttc ccgggaaagt gcgatacctg gcgcgcgcaa
      361 gtaccgcact ttcccgggaa agtggcgtgc ctagcggatc acctcggcga tggcgtcgag
      421 gccgctgtcg agctcctcct cggagatgac cagcggcggt gcgaggcgca gcgtgttgtc
      481 gtgggtctcc ttgcagagca cacccttggc ggccagcgcc tgcgacgcct ccctcccggt
      541 gggcccaccg ggagcgatgt cgatgcctgc ccacaggccg cggccacgca cctcggcgag
      601 accgttgccg acgagctcgc cgagccggtt gtgcaggtgc gcgccgagcg cggccgaacg
      661 ctgctggaat tcgccggtct ccagtagcgc gatcacggcg cggccgaccg cgcacgcgag
      721 cgggtttccg ccgaaggtcg agccgtgctc ccccggacgc agcacgccga gcacgtcgcg
      781 gcgtccggcg acggctgaca gcggcatgat gccgccacca agagccttgc cgagggtgta
      841 gaggtccgcg cggatccgtt cgtggtcgag cgcgaacacc gtgcccgtgc gggccaggcc
      901 ggactggatc tcgtcggcga tcagcagggc gcctgcctcg tcgcagagcc tgcgtgcctc
      961 ggcgaggtag ccgtccggtg gcacgacgac gcctgcctca ccctggatcg gctcgagcag
     1021 tacggcggcg gttcgctcgg tgatcgccga ggtgagggcg tcggcgtcgc catatttgac
     1081 gaccttgaat ccgggggtga acggaccgaa gtccgcgcga gcggtgtcgt cggtggagaa
     1141 ggacacgatc gtggtggtgc ggccgtggaa gttggacccg gccaccacga tctcggcctc
     1201 gccctgcggg acacccttca cctggtacgc ccacttgcgg gccaccttga tggcggattc
     1261 gacggcctcg gcgccggagt tcatcggcag cacgagttcg gtgccggtca gctgcgccag
     1321 ctcgcggcag aacagtccga gctggtcgtg atggaaggcg cgcgaagtca gggtgacccg
     1381 gccgagctgg gcgaccgcgg cctcgaccag cgcggggtgg cggtgaccga agttcagcgc
     1441 ggagtagccg gacaggaagt cgaggtagcg ctcgccgtgg acgtcggtga cccacgcgcc
     1501 ctccgcttcg gcgatgacca cgggcagtgg gtggtagttg tgcgtgctcc actgctcgtc
     1561 gagggcgatg aagtcggaag cggtacgggt ggtgctgtcg gcgaacgtcg tcatgcgttc
     1621 aggctaaggg cagtccacgt gtggttcatc cgcgacacgt tgcttgttgc ctgtgttcgt
     1681 tgcgtagttc tcgccggtgt ccggcgaatc gttgcgtacc cattgacttt cggagttgtc
     1741 agccgccccg cggtgtccca gcacctcaag gtgctcaagg actgcggtct cgtaaccgat
     1801 cacgtgcgcg gaacgcggcg gatgtaccgc ctgcgactcg aaggagtcgc cgggctgcgg
     1861 gcatatcgcg acgagatgtg gaccgaggcg ctgaccgcgt tcgcggcggc ggaacaggat
     1921 ggcgatgacg acgaatgacg cagcagacag gcaccaacct gcgccagggg gtcgacggag
     1981 gctggcctcg ctgcctggac aggttcgctg aactcgcggt gaagtgagcc ggtggggcac
     2041 gagcgggtga cgtgccccac ttcgagtgtt ggcacacccg ggcgtccttc tgacagagtg
     2101 tcaacccgtg accgacgacc tctccttcct tcgtaagcag gctcgtacgc agcgcttcac
     2161 ccttggtgcg ccgaaggagt tccgggtgtc cccggacggc gaccgggtgc tgttcctgcg
     2221 ggcggaatca ggtgtggacc gcaggcacag cctgtggtcc caggatctgg cgtccggcgt
     2281 ggagtccaag atcgtggacg ctgtcgcgct gttgccgggg gaggaggagt tgccgccgga
     2341 ggagcgggcc aggcgcgagc gcacgcgcaa cgcctccggc ggcgtggtcg gctacgcgac
     2401 cgattccggg ctcacgatgg cggcgttctc cctgtccggc aagctctaca cggcggacct
     2461 gcgttccggt gacgtcacgc tgcgcgtcga cgactccgtg gtggacccgc ggcccaacgc
     2521 ggcggggacg cacgtggcct atgtccggga ccgcaggctt cgcgtgctcg acctggccgc
     2581 gggcaccgac cggatgctcg tcgacgaacc gggagaggac atcgcctggg ggctggcgga
     2641 gttcatcgcg gccgaggaga tggggcgcgc ccgtggttac tggtgggcgc cggacgggca
     2701 gagtctcctg gtcgagcgca ccgaccgtgc ggcggtgccg cgctggacga tcgccgatcc
     2761 ggcgaatccc ggcctgcccc cgaacacggt gtcgtatccg gcagccggaa cggtcaatgt
     2821 cgatgtgtcg ctggcgttcc tggggctcga cggaacgcgt gtggacgtcc agcgcgggga
     2881 ctgggagtac ctggcggcgg tgcactggag tgcgggtggg gcaccgctgc tggccgtgca
     2941 gccgcgcgat cagcgccgcc tcgaggtgca cgaggtgaac cccgccgacg gttcgacgaa
     3001 gctgctgcac accgagacgg acccgcactg ggtggagatc gtgcagggcg tgcccgcctg
     3061 gaccagtgac ggcaggctgg ttcgggtgag cgcggcggac gggaactacc ggctgctgat
     3121 cgacggcgag ccggtcaccg aacccggcat gcagcttcgc tcggtcctcg atgtgggcga
     3181 ggaggtcctg ttcagtgcgt cggaggacga tcccacccag atccacgttt atcgcactga
     3241 cggtggaaag gtgcaacgtc tatccactga ggacggagtg cacatcggcg gtgggaacgc
     3301 cgcgctgacg gtgctgtcgt cctggagcat gtcccgcagt gggcccaagg tgtcggtact
     3361 gcgggacgga aaaccggtcg ccggaattgc ttcgtacact gtggaccccg gcacggcccc
     3421 caaggtggcg atgctgaccg tcggcgagcg gggcctgcgt gcggcgctgc tgctgccgac
     3481 cggtcaccgc gcgggttcgg cgaaactgcc ggtgctgctc gatccctacg gcgggccgca
     3541 cgcgcagcgg gtgttgcaga gccgcaacgc cttcctcacc gcacagtggc tggcggatca
     3601 gggtttcgcg gtgctgatca ccgacggcag aggcagcccg ggacgcggac cggagtggga
     3661 acgggagatc gcgggcaagc tcgcggaagt gccgctggcc gaccaggtcg acgcgctgca
     3721 cgcggtggcg gccgaatacc ccgatctgga tctggacagg gtggcgattc gcggctggtc
     3781 ctacggcggt tacctctcgg cgctggcagt cctgcgcagg ccggacgtgt ttcacgcggc
     3841 agttgccggc gcgccggtga ccgactggtc gttgtacgac acccactaca ccgagcgcta
     3901 cctcggcaca ccacaggacg aaccggattc ctaccgccgg aactcgctga tcgccgacgc
     3961 cccggagttg cgcggcgcgc tgctgctcgt gcacgggctg gccgacgaca acgtgttcgt
     4021 cgcgcacgcg ttgcgactgt cgtcggcgct gctggcggcg ggcaggccgc acactttcct
     4081 cccgctcgcc gggggcacgc acatgacacc gcaggccgag gaggtcgcgg agaacatgat
     4141 gcggctgcag atcgactgga tcaagcgcga gctggacgcc cgcgtcgggc actgatccgg
     4201 gccaggacgt caccgatcga ccgaggatgg agcgtatgaa gcgttgggga atcacgatcc
     4261 cgctcaccgg ggtcccgctg gccgaacacc gtgagctgat cgagcagctg cccgacctcg
     4321 ggtacaccga cgcgtggtcg gcggagaccg cgggcaccga cgcgttctcc ccactgctgc
     4381 tggcatcgca gtgggcgccg cagctacgcc tcggcacggc catcgttccg gtgtacacac
     4441 gcgggccggg cctgctcgcg atgagcgcgg cgaccctggc cgagtgcgcc cctggccggt
     4501 tcgtcctcgg gatcggtacg tcatcgccgg tgatcgtgga gaactggaac gcggcggagt
     4561 tcgccgagcc gttcggccgg agcagggaca cgttgcggtt cctgcgggcg gcgctggcgg
     4621 gggagaaggt caccgagcag tacccgacgt tctcggtgag caagttccgt ctggagcggg
     4681 cgcccgagcc cgcgccgccg atcatgctgg cggcgttgcg tcccggcatg ctgcgactgg
     4741 cggcgcggga ggccgacggc gcgatcacga actggctcgc gccgggtgac gtgccgacgg
     4801 tgcgggcaga ggtcggcccg gacgtggaac tggtggcgcg ggtgttcgtg tgcccgacgg
     4861 aggacgccga cgccgcacgt ggcctgggcc gtatgttgat cagtagctac ctcaccgtgc
     4921 cggtgtacaa ggcattccac gaatggctgg gccgagggga cgcgctggcg ccgatgcacg
     4981 aggcgtggca ggcgggggac cgcaagcgag ccggtgaact catcccggac gatgttgtgg
     5041 acgacctgat cgtgcacggc agtgtcgacg agtgcagaga caaggttcag tcctacgtgg
     5101 acaacggact gaacactccg gtgatggcgt tgctgccgac cggggacaac ccgttcgagc
     5161 acatcaaggg gctggctccc aggtcctgat ccgttcgccg cgagcgcgcg tcaaccccag
     5221 atcgcgttcg cggcgaccag gcctgtcgcg gcggcgccga agccggcgag gacggtgacg
     5281 acgacgttgg cgacggcgtg gaggcgggcg cgttcggaca cgagccggac ggtttcgtag
     5341 ccgaacgtgg agaacgtcgt cagggagccg cacaggccga cgccgaccag tgcccggacg
     5401 gtgtccggct ggccaccggc gagtgcccag cccgccagga ccccgagcag ggcggaaccg
     5461 gtcatgttgg ccacgagggt gccccacggg aacagggtgc ggtggctgcg ccggacgcgc
     5521 tggtcgacga gatagcgcag gatggcgccg agggctccgc cgacggcgac cagcagcgcg
     5581 gtcacggtgt cgcccctcgg cgtacgtggg tcacggcgac gcgggtggcg cgcatgccga
     5641 gcgcgacggc gagcagggag gcgagcaccg agaccgcggc gtagagcagg gcgagccccg
     5701 ggcggccggt cagcgcggag tccatggcct cgaccacgaa agtggagaac gtggtgaagc
     5761 cgccgagcac gccgatcccc gcgaacgggc ggagcagcgg gtgcgggtcc cggatggtga
     5821 tgatcagcat catcagcacg ccgatcaaca ggcagcctcc gatgttggcg agcagcgtgg
     5881 cggtgccgaa ctggccgcgc tcgtgcggga gggcgaggcc gagcccgtac cgggcgaggc
     5941 tgccgagcgc gccgccgacg gcgaccgcga gcagcaccgt ccaccggtgt ggctcaccca
     6001 ctctccggcc catccgtctc ctcacccctc gcactttccc ggaaaagtgc ggtagttgcg
     6061 cgcgcggggt atcgcacttt cccgggaaag tgcgagtccg aaagctctcg tcccaggtcc
     6121 cgggcttgcc cccgcgcact ttcccgggaa agtgcgcggg gtagttcccg gggaatctat
     6181 ccgcgggatt ggcttcgcgc cccttcgggt agtcgtggcc gggaggtcag catgggacac
     6241 ggcgtcgcag aacaactcat cagcgaacac ctggtcagcg gggagatgac gccgggggcg
     6301 gaaatcgccc tgcgggtcga ccagaccctg acccaggacg ccaccggcac cctggtaatg
     6361 caggagctgg aggcgatgaa tctcgatcgg gcgcgcaccg aggtcagcgt gcagtacgtg
     6421 gaccacaacc tgctgcaggc cgacgagaag aacgcggagg accacgcgta cctacgctcg
     6481 gcgtgccgca ggtacgggct gtggttctcg aaggcgggca acggtgtttc gcaccccaca
     6541 cacatgcagc ggttcggcat cccgggcaag ttgatggtcg ggtcggattc gcatacgtgc
     6601 gccggtgggt cgctgggaat gctggcgatc ggtgtcggcg ggctcgaggt ggcgatggcg
     6661 atcgccggta cgccgttgta cctgcagatg ccgcggatct ggggcgtgcg gctgacgggt
     6721 gagttgccgc cgtgggtgtc cgcgaaggac gtggtgctgg agatgctgcg tcgccacgga
     6781 gtcaagggcg ggctgaaccg gatcatcgag taccacgggc cggggctggc gcagctgtcg
     6841 gcgatggacc ggcacgtgat cgcgaacatg ggggcggagc tgggggccac gacgacggtg
     6901 ttcccggcgg acgaggcggt gcgggagttc ctgcgcgcgg aggaccgcga ggaggacttc
     6961 cgggaggtgc tgcccgcgga ggatgcacgg ttcgacgaca ccgacgagat cgacctgtcg
     7021 acgctggagc cgctgatcgc caagccgtcg tcaccgggca acgtggtgcc ggtacgcgag
     7081 gtggctggcg ccgacgtggg ccaggtggtg atcggctctt cggcgaaccc ggggctgcgg
     7141 gactacgcga tcgcggcgca catggtgcgc ggcaggcaga cggaggactc ggtgagtttc
     7201 gacgtcaacc cgtcgtcacg ggagatcttc gcggacctga cgaagatggg ggcgacgttc
     7261 gagctgatct cggcgggggc gcggatccac caggccgggt gcatggggtg catcgggatg
     7321 ggacaggcgc ccgcggtggg ccacaactcg ctccgcacct tcccgaggaa ctttcccggc
     7381 aggtcgggca cgaaggagga cgccgtctgg ctgtgctcgc cggagaccgc gacggcggcg
     7441 gccctgaccg gggtgatcgc cgacccgaga gaggtcgccg agcggctggg gatcgaatac
     7501 gtgcgcccgg aaatgccgtc gcgagcatcg gtgaacacgg acatgctggt gccgccgctg
     7561 gagccagggg aagccgagag ggaggagttg gtgaaggggc cgaacatctc ggcgctgccg
     7621 gacttcccgc cgctgccgga ccggatcgag gcgccggtgc tgctcaaggt cccggacgac
     7681 atctcgaccg acgagatctc cccggccgga gcgcgggcgc tgccgttccg ttcgaacatc
     7741 ccgatgctgt cggagttcac cttcagtcag gtggacgaga cctacccgca gcgggcgcgc
     7801 gaggtggccg acggccccgg ccacctgatc gtcggcggcg acaactacgg gcaggggtcc
     7861 tcgcgcgaac acgcggcgat caccccgcgg catctgggac tgcgcgcggt gatcgcgaag
     7921 tccttcgcgc ggatccactg gcagaacctg gcgaacttcg gcatcctcgc gctggagttc
     7981 gtcgacccgg ccgactacga acggatcgat cagggggaca cgctggagct ggagagcctg
     8041 cgggaagggc tgtcggagag cccggagctg acggcgcgga acgtgaccaa ggacgagcag
     8101 taccggctgc accaccggtt gtcggagcgt caggtcgaag ccgtcatggc aggcggccgg
     8161 atcccgctgc tggcgtcgat ggtctgagcc gttgttccag gtcagcgtcg gcgcgcgccc
     8221 gacgttcgcc cctgcctcac gggcgctgaa gcggacacgc taagctagcg cccatcgtca
     8281 gcacgcaggg cgatggccgg gctgtggcgc agtttggtag cgcacttgac tgggggtcaa
     8341 ggggtcgcag gttcaaatcc tgtcagcccg accggcaagc gggttcttgc agttcagagc
     8401 tgtgggaacc cgcttttttt gtgctgtagg tgcggatctg gtctacggtc cagcgcgacc
     8461 cggcgcggca ctgtgacact cgcatctgtc atcggtgtgg gcacgtgcag atcggtgctg
     8521 gcggcgttca tcgccgcccg atagccgggc ctgctcgtct gccgaatgtc ctcgatcact
     8581 cgacaaagac gaacttgcct tggccgtcaa ccttcattat ggtcaggtta gtgagtacct
     8641 actaaccatg tggaggattc gagatgcacg ctccgttcca gaccaccagc gcggatgcac
     8701 gtgccctgtg gcacatgggg gcgctgttac ggctcaaggc aaccggggag gacaccgcgg
     8761 gacagttctc cctcaccgaa cacacgtgcc gacagggcac agcgtcaccg ctgcatcggc
     8821 acactcggga ggacgaggcc ttcctcgttc tggaagggga gttgaggatc tacatcgacg
     8881 ggcggcacta ccacgcccag gccggctcac tcaccttcgc gccacgcgga ctcccacacg
     8941 cctaccgggc aacatcgccg acctgccgct tcctcgcgct catcacgcct ggtggcttcg
     9001 agcagtggtt cgccgaaacg ggagaaccgg ccctctcgcc gaacctgcca ccagcaccgt
     9061 ccggccccgt cgacacaacg aggttgatca gcgcagccgc ccgatacggc gtcgaggtgc
     9121 tggggccatc accgatcgtc gacgacgcca caacgcatgc ggacccgcgg tgaggaaggg
     9181 aaatatgcac acaactcgag gcgccgtgac cgcgttggtc accggtgcgt ccgccgggat
     9241 cggccgggcg accgcggtgg cgtatggcgc taccggcgct caagtcggta tcacataccg
     9301 aaaggatcgc gcggctgccg aggagaccgc cagacaggtt cggtcggtgg gcggacaggc
     9361 gctaccggtc gcgctggacc tcggtgaccc gtccggcatc gcggcggcgg tcgctaccgt
     9421 gcaaggctgg gccggcgaca tagacgtgct ggtcaacaat gcctacgacg ccggagagtg
     9481 gaccccaggc acggacacag cattcgaaga cattccggta gggcaatggc aacacatcct
     9541 ccggcaaaac ctcgagggcg ccttccacgt ggttcgcgcg gtactgccag ggatgcgccg
     9601 acgcgaagca ggccggatgg tgctgatctc ttccggagcg gtcgaacatg gctcgaccgg
     9661 caccggaccc tacgcggcgg ccaaggccgg gttgcacgga ctgtgccgca gccttgccgc
     9721 cgaactcggg cctgccggaa ttctggtcaa cgtggtgatg ccgggcatca ccacgacgga
     9781 gcgggcgctt cggtcgctgc cgcccagcct tgtcgacgcc gtcaccgacg ccacaccgac
     9841 gcgacgtctg tccacacccg acgatgtcgc tcagtcgatc ctgttcctgg gctcgactgc
     9901 caatggcaac atcaccggcc aggttgtgcg ggtcaccggt gggcagtgag ggcaggacgt
     9961 gtcatcgtaa gcccggacct ggagtgcgga tcgctccctt tcagaccttc aacggctcgt
    10021 cccgcatcgc tacgaacgct cgggcggcga tgaagtacgg ccgtgcttgt tcgcggaact
    10081 cctcgaggga ccggaaaccg cggtcgagca cgtgggtcgg cagttcgtcc gtgcgccaca
    10141 gctcggcgaa cttcgcatcg atcaggtcgg tggggatgtc gcccgggtgg aacttcgggt
    10201 tgcgccgcat cgcctgactg ttcaagcgga gcagcctggc gctctgctgt gtcaattccg
    10261 tcatgtcggg atccagttcg ggcgggacct cgtcgtagac cagccgcccc gagcgtctcc
    10321 gaaatgtgcg cacgagtacc cgaatcgcac ggtcgtgttc gtcgagggtc tccagttcgc
    10381 cacgagccag gatgccgcgg cgaacgagtt catcggctga cagggcatcc agccagggcg
    10441 gtaggaagac gtcgtacccg gtcgccggtg aactgccgta cgcggcgagc ccgacctccg
    10501 ggtactcagg gcgcagattg gccagcacgt gcgcggtgtg gcggtccggg aagtccggga
    10561 ggaacaattg cgcgtaggcg agcaactggc gtcgggtcgg gccatcgata tcggctgtgg
    10621 ccggggtgtg ctggagccgc cactccttgt ggtaagtggt gagcggtacc tcgatctcac
    10681 cggctgatgg cgccagcacc cttccggcaa gaaggtcgtg gatcgcgctc tcggcgtcga
    10741 ttcgcttgat gtcgcccagc cggtcgttgc gcagttcgtc gacgacgagc cgcaccgaat
    10801 cagccagctg ttgctcgcct gccgacgcca gcagggccgc gttggtgcgg atgctgaagt
    10861 gcagcgaccg ggcgagctcg acgacccgtg aagccgcggt cggatcgaga tggccggcgg
    10921 ccgccaaccg gtcggtcacg ccgatgatgc tcacgagcgc gtgggtgaag gcccggaagc
    10981 ccacatcggc atcgccgtgc gtgagcgcga catcggcatc ggagatcagc cggccatccc
    11041 tgtaccaggc gaatacggtg cccagtccgg tcataccgtg gtcctggtgt tcgcatgcgc
    11101 gcagcgcacc aaggctcgcg gccccgtaga tggggacacc ggccgcgtac aggtcgagga
    11161 tctccttgtg ccggaccggt gcggtgtgct ggtagacacc atcgacgatg agcacagagt
    11221 cgtcggttcc cggccgaaga cggtagagat cgccgtgagc gatcgggggg tgtgcgcata
    11281 caccgtccag gtcgagcacg gacgagccgg acagtgaggg cccggcgaac acgtggatcg
    11341 tcatgaggct ccttcgccgc tgtcgtgcgg atgggtgctc gtcggccgcg gttgcgtgtc
    11401 ctccggatcg gggtgacggg gcagctcctc gttcgcctcg tgaagcagct caggaagccc
    11461 gggcgcgacc accttgcata cggcgaaggg ttccccgggc ggggtcatat cgacgcgcag
    11521 caccggacga cccgacatca cgctcacctg gtcgaccagc caggcgagca tgtccgcgct
    11581 cggaacgctg gcatccactg gtggagtggg gatcgcgttc cacgagtggt tcggttcgac
    11641 gggcaggggc gggacgggac gccgcacgcc tcgataggac acactcccga tgtcctcgcg
    11701 ggtgccgctg atcaccgaca tgcggctctg gaccgcctcg gtcaacgctc tctggacagc
    11761 gatctcaggc aggaaatggc tcccagatcc cgcatagaga ctcggcatgt cggggtgcca
    11821 gaggaagacg gcgaacgcag acacgcctgg tacgaccgaa cagtccacga cctccaccca
    11881 gaaatcgatg tcatggagat gctcgacgag atcccgactc cagcagtcgg gcagggtgcg
    11941 tagatccagc acttttcgct gtcggatggg cgttttcgcc acacccgctg tcgagtacct
    12001 ttcgatgacc tcgagcagcg catggatcgt ggcttcggcg agggtgttgc cgctggccag
    12061 tccattggcc gagcagaact gcgtcgatgg tcgccaggtg ccgtcggaga cgccatccat
    12121 cgcgaccgag cggaggggga cgaacgtcgg ctccccatcg gccagggaga ccgccgggac
    12181 ccagcgcagc gggaagcgat cggagatgat cgagcgctcg gtgggggttg tctccgatgt
    12241 ggcgtacggg agatcgagct cgacggcctg cgcgacgaag gcgtcgggcg tggtgaagta
    12301 ccgctcgcag acggacatct cgatggcttc catgacggcg gacagtcgtg cgagcagagg
    12361 agtagcgccc ttgccctgac ttacacccac tgtggtcgcg aggggtcgca cggccatgta
    12421 caccggcatg ccgatgatgt cgaggccggt gagttcggcg atcctggtga ccccgtactc
    12481 acgcatcctg ggccgcacga actcccatgt gtcctcgggg gaacggtccc gcaacgtgcc
    12541 agggaggacg acaggaccaa tactcgacgc gacgtgcgga gataccatca ttgtcctccg
    12601 ggtttggggc tccgacagcg cattccgttg cttacccgaa ctgtggctaa tgtcccgcgg
    12661 ccgcgacttc gttctccgcg agcgttgtgg ccgaatcatc gggtgcggcg gttcctcggc
    12721 gcgccttccg cagcagcacc ggggcgagca cgccggcggc tacggcgatt ccagcaccga
    12781 cggtgagggc cgtgctgact ccgtcggtga acgacgacag ggtgtcaccg cctcgctcgg
    12841 tcgcccgtga gttggctgtc gccgcgaccg tgctgagcac cgccaacccg accgcgccgc
    12901 cgatctgctg ggtgacgttg accagtcccg cagccaggcc ggcgctgtcc agcggtgcct
    12961 cggcggtggc ggcgatcatc agcgagatga cgccgagcgt ggcacccaac gcggtcatgg
    13021 tcagcggtgc catcacgtcg gtgaagtagt tgccgttcac ctcgacctgg gccaaccaga
    13081 acatgcctgc cccggcgatc agtccgccga ccgttgccgg gatgcggtat ccgatccggc
    13141 tgaccagttt gccgacatgg gttcccagca gtgcgaagca caccgccgcc ggcatctggg
    13201 ccagcccggc ctgaatcggt gtgaagccca gtacgtgctg cagatacagg gtgaggaaga
    13261 agaacatggg cgtcatggcg cccatggtga gcagcgtgag accgttgccg ttgcgcagcg
    13321 acgcgatccg gaagattttc agcgagatga gcggctgact gctgcgtgcc tcgatcgcca
    13381 cgaacgcggc aagcagtgcc gcggccgcgg tgaacaggcc gagcgtctgc gcggaggccc
    13441 agccgacatg tgcggcattg atcaacgcgt acaccgccag cgaaacacct ccggtgacgg
    13501 tgacggctcc ggcgatatcg aacgaacggt ggaccgcatc cttggtctcg ggaagcaact
    13561 gtggagccag cagcaccacc acggccacga tggggaggtt gacccagaac accgcctgcc
    13621 aaccgaacca ctcggtgaga aggccaccga agacgtatcc ggtggcggcg cccgtggcgg
    13681 ccaccgaccc ccagataccg agggccttgt tccgctcttt ttgttccgtg aacagggtca
    13741 tgaccagagc aagtgccgcg ggtgacactg ccgcggcacc catgccctgt accgctcggg
    13801 cgatgatcag ccacagcggt gaggtggcga gcgcaccggc cagcgagccc accgcgaaca
    13861 gtgaaaggcc ccagatgaac attcggcgac gtcccacgat atcgccggcg cggccgccga
    13921 gtagcagcaa gccaccgaag gcgagggcgt atgcgttcgc tacccacgag agtccctcgg
    13981 gggtgaaccc caggtcagcc tccatcgatg gggcggcgat gatcacgatc gcggtgtcga
    14041 cgacgagtac gaactgggtc attgccaaca gcgccagtgc gagccaccgt cgagtgggtg
    14101 ggcgtgatga cgtcaccgtg tctcctgagg ttaccgagtt gtcgggatgt gaactcctgt
    14161 tttgttcacc ctgaaacacg atagggaact tcggttccgt tcataccctt caagattgcg
    14221 tagcacggca aagcaattta agagacgcct gccggagcga tcggagcatc agatcagaat
    14281 gccactgaac tgaggagacc acgaaatgtc gcgaccgaga accttccccg aagcgttcca
    14341 aaggactgtg gcggcacatc cggaagacgt cgcgctgcgc acgccggacg acagcatccg
    14401 gttgacctgg aaggagtacg gcgacgaggt gcgcaggatc gcctccggat tggcgtcgct
    14461 cggagtgaag cggggcgaca cattcgcggc catgctgacc aaccgccccg agttcaacct
    14521 gaccgaggtc gcggcctccc atctcggcgc caccacgtat tccatctaca acacgagctc
    14581 gccggagcag atcaactacc tgctcaccca tgccggtacg aaggtcgtgg tctgcgaccg
    14641 gcagttcgcc ggccggatca aggcatccgg agccccgctg gaacacctgc tggttgtcga
    14701 ggacggtgat ctggaccggc tgcggcccgc gtcgggcttc gaattcgagg ccacctggcg
    14761 tgcggtggag ccggacgacc tgctgtgtct gatctacacc tcagggacga ccggcccgcc
    14821 caagggtgtc gagcacacac accggggctg gcttcggatg atcgactcga tcgccaccat
    14881 ctggccactg gaagcggggg atacggcgat ctcctacctc ccttccagtc actcggggga
    14941 ccgcttcttc cgccactact acgccatcgc gcgcggcgcg caggtcatca gcgtggccga
    15001 cgccagtcgg cttacggagg cgatcgccga ggtacatccg accaccttcg cggccgtgcc
    15061 acggacgtgg gagaagctca aggcccatct cgagcgagag ttgctgaccg acgagaaggc
    15121 tgccgccgcg ttcgcggcgg gcgagccgcg tctcctggac gcgatccgtg tcaagatcgg
    15181 gttcgaccgc ctgaagtggg cgctgacggg caccgcggcg atcccggagc acgtctacgc
    15241 cttctggcag aagctcgggg tgccagtcac cgttggctgg ggcatgtccg agtgcggttt
    15301 cggtgcggga tcatctcctt cggggtccag gatcggcacc atcggcacga ttgcccctgg
    15361 cgccgaggca cgcctctccc aggacggcga gttactggtg cgcatgccgt ggatgatgcg
    15421 gggctaccgc aaggacccga cgaagaccgc ggaagcgctc gacccggacg gctggctgca
    15481 caccggcgat ctcgccgaaa ccgacgatga cggcaactat cggatcattg gccggaaaaa
    15541 ggaactgatc gtcaactccg gcgggaagaa catgtcgccg agcaacatcg agcacgccat
    15601 tgcggagggc acgtcgctga tgggaccagc gatggccgtc ggtgacgaca aaccatacaa
    15661 cgtagcgctg atcactctgg acccagacgc cgctgtggcg ttcgcgagca aagtcggtgt
    15721 tgcggcggat ccggtcatcc tggccaagga tgagcaggtg ctggagaaga tccgagccag
    15781 tgtgtacgcg ggcaatcaga aactgtcccg gatcgagcag atcaagaagt tcacggtgtt
    15841 gccgacattc tgggaagccg gcggcgagga actgacctcg acgatgaaac tcaagcgcag
    15901 gtctatcgcg gagaagtacg cagacgagat cgacgccctc tacgcgtcga ccacctgacg
    15961 tggcaccgat cgcttgcgtt tacccgctct ccgccctctg ctcgtcgctg cgtgccccca
    16021 gcacggcggc agcagcaatg tggactaccg cgtactcgat gctgtcatcg cgcgacccgc
    16081 gagccgggca acatccgccg caatccagga gtggtattcc aggtctgacg gcgacattat
    16141 tgtaattgcc cgtccgggca attactccct caacaaaatg gaggaaacaa tgattgacat
    16201 cgcccagatc tccgacaacg agctgctgac ggctgccggc gcgacctcgg tcgacttctc
    16261 cgacgcggcg accgctccgt cggtcatggc cggagagccc tgcgacagct aaggcaaact
    16321 cttagggtgg tgccgcgaac gcggcaccac cctaatgtct atggcgcagt ttcacggtgc
    16381 ctctgtgagc agaaaaagcg gttacgcggt cggtcgcgtc agcacatgaa ggaatgacgg
    16441 atgacacgaa attccaccaa tgacgagccg cgcacacagg tgcagtcatc gtccgggcaa
    16501 atcatgaccg ccatgcctct gggctccttg ctgatcggag tgtgtggctc aagcgccgcc
    16561 gagtcgaccg gggaactggc ggaggaggcc ttgcgctacg ccaacgacat caccgtggtc
    16621 gccactcgga ccgcggccgc attgttcgtc tccgacttgc cggtacccct gtacaccgac
    16681 gcggactgga tcgacaaacc acttcatgtg actctgctgc aacaggccga caccctggtg
    16741 atcgcgcccg ccaccgcaac gaccctggcc aaagctgccg ccggtatagc cgacacattg
    16801 gtgaccgcgc tgatttgtgc ccatggtccc ggcgtctact tccagccgtg tatgaacgcc
    16861 cgcatgtgga ccagtcccgc tgtacgccgg gcggtcgaca cccttcgcgg cgacggacat
    16921 catgtcctgg aacctggccc cgtcgcttcg cgcgccagcc ggaccgtggg ttccggagtt
    16981 ggggagattc ccggcaacgt gctggccacc gtcgccgagc acaagcgcga atcgggtcga
    17041 aactgaccgg cgcggactcg gcaatctgag agatgggcat cgggcatcgc tgcgcctaac
    17101 gtttcccaca cctggccgat gccgctcgat cgaacgaagg agctacagac atgcctaagg
    17161 tttcatggga cagcgcatcg aagatcgagg aggtcggccc cgtcagggat cgattcgaga
    17221 ttctcgacgg ctactcggcc aacttcaccg tgttcgacga ggacatcgat gccacctcgc
    17281 tcctcaaagg actgccagaa gaccgctgcc aatgcccgca ctggggatat gtcatcaagg
    17341 gcaggatgac cgttcgcctc ggcgaccagg aagaggtcta cgaggcaggc gatgcgttct
    17401 acaccccacc cggccacgtc ccgctgaagc accaggccca caccgaggtc atcatgttca
    17461 gccccgaaga ggaactgcgc aggacagggg cggcagtggc gcagaacgcg gaagcggagg
    17521 gcatgcacgt gcgaaggccc gaacagcagt agtgacgcca agccgcgtcc actcacatgc
    17581 cagcacgaac agtcaagccg acctcaagga ggtcccagtg ttcgacgtga tcgtcatcgg
    17641 aggtggaccg gccggtctct ccgctgccct taccctcggc cgcgcgctcc ggccgaccct
    17701 cctgatcgat tccggcgagt accgcaatgc acccgccgcg gacatgcaca acttcctcac
    17761 tcgtgatggc acaccgccaa gtgagttccg caagatctcc cactcggaac tcgaccagta
    17821 ctccactgtg gagatccgga acgtgacggt cgacgacacc aggccgctga aagatggcga
    17881 cgggttcgag ttgacgttga cggacggctc ggccgtccag gcgcggcgtc tgctgctcgc
    17941 cacgggcctc gccgacgacc tgccaccgat cgagggcatc ggggagttgt gggggcgcgg
    18001 tgtctaccac tgcccgtact gccacggctt cgagatccgc gatacgccga tcgccgtcct
    18061 gtactcagat cccctgatgg tcgacctcgc actgcacctg cggaggttca gctccgacgt
    18121 ggtcctgtgc gccgacggtc gcggcgacga gctcgacgga tcgaccctcg cccggttggc
    18181 ggacaacggc gtggcggtcc gcggcgagaa ggtcgtccgg ctggagtcca acggcgagcg
    18241 gctggagaat gtggtcttcg aatcgggcga gtcgcttccc cggcacggac tcttcgccat
    18301 gtcccagttc aggcaacgct ccgagttgcc cggcaggctg ggatgccagt tgttgccgga
    18361 cggttgtgtg gcggtcgacg acttccagtt gaccagtgtc ccgggtgtgt acgccgccgg
    18421 ggacatggca cacagggcga gcctgccgat gccgaccccc tttgtcagca cggctacgtc
    18481 cagcggcacg atcgccgcga tcgcggccga caagaacctg gtcgccaccg acaccaccac
    18541 tcggcccgac cctgtccctg cctagaaagt ggctcgacac ccctgccggt gatcctcacc
    18601 ggcgggggtt cgtcatttcc ggctgctgag gccaggaaac aggtacggca tgatgacggc
    18661 gtgaatgcca cggtagcggt cgctttgatc acttcgttgt ccacactcgc cgcggcggcg
    18721 ctgaccggga tggtctcggc ctggtcgaac gggaggcagc tgcggcacca gcggctgctg
    18781 gcgcgagaac agcaggcgga ggagcgtggt gcacaacggc gtgagctgcg acgtgaggcg
    18841 taccaacagt tcctctctca ggccgatgcg gcctaccgcg tgctcgacga aggctggctg
    18901 gcggcgccat tcgccggatc ttcacgctgg gaggccggtt tcaccgctcg ccgagggctg
    18961 gacgaggcct atatccgggt ccagctcgaa gggcccgacc gggtcgcggc cgagggggcc
    19021 aatgtcgtgc gcagtatcgg tgacgagttc aggacacacc ggcgtgttct cgacgcgaac
    19081 cccggcacgc aggactgcgc tgccgagctc gaccgcgccg cccgtgccga cgttctccgg
    19141 gcgcgattcc ggacaagcaa ggatttcgtt gccgcggccc gcgactcgct gggcgacgag
    19201 ccgccccggg agctcccgga ggcgtagcgg gaccaggatg gccgggcacc cgaagccggc
    19261 gccgaacacc gtgcgcgcgc tccgtcaggg cctgacacac cggggcgaac tttgcgacga
    19321 atgggccatt gcaatgcgtg tgcgcctggg ttcaactggg tcgttcgctg agcgaaaggt
    19381 caggctatga ggcgaagata cgttgtcgtg ctgctcgccg cggccctggt cggtggatcc
    19441 gccaccacgg gctccgccgc tccggcgccc ccggccggtg cggaaggaga cctccgggcc
    19501 tacgctgccg agctggctcc ggccgaggtg catgatctcc gggccgaggg aatcgacgtg
    19561 ctggacgtgc caggaggcgg ggtcgagctg atcctcaccg accagcaacg cgaacggctg
    19621 cggtccaccg ggatcgagct gcgcccgaag gagccggccg cgcgtaccag atccgctccg
    19681 gagaccgccg cggacggcgt gtaccggccg tacagcggtc ccggcggtat cgaggaggag
    19741 atccggcgca ctgtcgccga caacccgcac ctggccaagc tggtgccaat cggtgagacg
    19801 cggcagggtc gggagatcct ggcggtgaag ctgacactcg gcgcccggtt ccttccggac
    19861 ggcgccaagc ccgcatcact gtacagctcc acgcagcacg cgcgggagtg gatcaccgtc
    19921 gagacgaacc ggcggctgat gcaccacatg atcgacaact acgggtccga ccgcgagatc
    19981 acccggttgc tcaaccgcaa cgagtactgg ttcgtcctcg tggtcaatcc cgacggctac
    20041 gaccacacgt tcaccgaggg caaccggctc tggcgcaaga acctcaggga caacgacggc
    20101 gacggggcga tcaccgtcaa cgacggcgtg gacctgaacc ggaacttcga ctacacctgg
    20161 ggttacgaca acgagggttc ctcaccgaac ccgaccagtc agacctatcg cggtcccgcg
    20221 ccgaactccg aacccgagac gcgggcgctg gacgatctct ttcgcaaggt cgacttcagc
    20281 ttcctggtca actaccactc ggcggcgcag ctgctgctct acggggtggg ttggcaggtc
    20341 aacaccgact cacccgacga cctgatcgcc aaaacgctgg cgggcaccga cgcgaagccc
    20401 ggcgtcgacg gattcgaccc ggatgtctca gccgagctgt acacgaccaa cggcgaaacg
    20461 accaaccacg cacaggcccg ctacgggatc atcagcttca ccccggagca gaccacatgc
    20521 caggccgcga gccggagcga tccgaacgac gaatggcgcc cggaagactg ccagagcggg
    20581 ttcaactttc ccgatgacga ggagctgatc caggaggagt tcgagcgcaa cctgccgttc
    20641 gcgctcgaca tcgcccgctc cacggcggac ccggcgaacc cgaagtcgca tctggggaac
    20701 accgcaccgg agatcgtcgc gaagcccgtc agcacctcgt tcggtgaaac ccagaccgtg
    20761 tccgcgatcg ccaagcggcg accggggccg gtcctggtcc gctaccggat caacgatggc
    20821 aggacgcgta tcgcgttcgc ccgtgaatgg gacggcggcg agcggtacgg cgacggcttc
    20881 gacgtccact acgaggaggt gcgggccgat ctccgcggcg cgggacccgg tgaccgggtc
    20941 gaggtcgtgt tccaatccca tggcaagcgc accgaaccgt tcacgtacac cgtcgagcgg
    21001 acggccgcga agccggtgct ggtcctcgcc aacgaggact acgagggctt cgacccgccg
    21061 gtgccgaacg cggtgccgca ggcccccggt ccgcgtcatc tcgacgcgta caccgcggcg
    21121 ctggaggcca acgacatccc ctacgacgtc tgggacatga cccagcgtgg cgcgccggac
    21181 ccgctcggcg ttctcgccca ctacgaggcg gtcgtctggt acaccggcga caacgtggtc
    21241 acgcagcgcg agccgggcgc gggcgacaac atcgtggcca aggtgcagca ggacacgaca
    21301 ctcgctgtcc gggacttcct gaacgagggt ggcaagctgc tgcacaccgg tgagtacgcg
    21361 ggctatttcg ggccgaatgg ttcgctgttc ttcgacaatg ccgaggagcc gtgtgcgccc
    21421 gagtcgagct cgttccggct gtgcgtcttc tccaacgact tctaccagta ctacctcggc
    21481 ggattctccc ggagctcggt gaactccccg gacgaggtca ccggtaccgg acggccgttg
    21541 gcgggcaacc tctcgctcgt gggtggcgac ggggcaggca accaggagcg acctggcgag
    21601 ttccgggtga ccggtgacgt gctgccggag gaggacttcc cgcagttcag gagcagcgag
    21661 gccgcacggt acgtaccgac cgggcccgag ccggagcagc cgttgagcgg tgagtggtac
    21721 gcgggcgcac tgcacgacga ccagtcctat cagcgcttga cgcggacgat cgacctgtcg
    21781 tcggcaggtg ccgcgtcgct cgggctgaac ctctcctacg atctggagac cggctacgac
    21841 ttcgtcatgg tcgaggctcg agtcgtgggc acggatgggt ggacgacgct cgcggacgcc
    21901 gagggcaggg ccacctcgac agtgccgacg cagtgtgagc agggtttcct gctcgcgttg
    21961 cacccgtggc tggagcggta cctgacggtc gacggtgact cctgcctgcc ctcgggaacc
    22021 agtggttcct ggaacggttt caccggaagt tccgggtggg gaccggccac gttcgacctg
    22081 tcccggtacg cgggggagca ggtcgaggtc gcggtcagct atgtcaccga tccgtccagt
    22141 ggtgaggtgg gagccttcct cgacgacacg tccgtcaccg ttgacggcca ggtcgccgag
    22201 gagagcggat tcgaggacgg tctcggaccg tgggccatcg caccgccacc ggagggcagt
    22261 gccgacaccg gagcggcgtg gcagcggtcg cggtccttgg tgcaaccgcg cgccgccgcg
    22321 gtcaccacgg aggacagcgt gtatctcggt ttcggactgg agtcccttgc gacggccgaa
    22381 cagcgggcga aggtgctcgg tgacgcactg cgccacctgc tcgaaccagc cacataacgc
    22441 gtcaaccaga gatgcaggat ggcggtggcc agcacatgtg tcaccggtcg tgatcgccga
    22501 ctcgtgttcg aacacctgtc gggcttcacg accg
//
