LOCUS       NZ_FOKG01000003        25293 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Amycolatopsis marina strain CGMCC 4.3568, whole genome shotgun
            sequence.
ACCESSION   NZ_FOKG01000003
VERSION     NZ_FOKG01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis marina
  ORGANISM  Amycolatopsis marina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900111885.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:41:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,708
            CDSs (total)                      :: 6,643
            Genes (coding)                    :: 6,572
            CDSs (with protein)               :: 6,572
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2, 5 (16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 22 of 71
            Pseudo Genes (incomplete)         :: 62 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 15 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:06:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 52027
            Orig. end                         :: 77320
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOKG01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25293
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..25293
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25293
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15293](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15293)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            565..2796
                     /locus_tag="BM199_RS06470"
                     /old_locus_tag="SAMN05216266_10358"
     CDS             565..2796
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013674015.1"
                     /locus_tag="BM199_RS06470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10358"
                     /product="bi-domain-containing oxidoreductase"
                     /protein_id="WP_091671119.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.4e-14, bitscore:
                     48.7, seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 4.6e-24, bitscore:
                     79.9, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 2.3e-09,
                     bitscore: 31.8, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQVVQNYKSGELTLIDVPEPACKPGGVLVRTDFSLISTGTEMMK
                     VSEASMSMLGKAKARPDQVAKVMQSVAGNGLAATYRKVNNKLDSYTPLGYSLCGVVEEV
                     GAGADVSVGDIVACAGNEHALHAELNWVPRNLYSRVPDGVDPRHAAFGTVGAIAMQGVR
                     RGEPQLGELALVIGLGLIGQLVVQLLTAAGVRVVGVDPDPDRCALAERLGALVCSAPGS
                     GVVDSAVGELSGGHGVDQVYLAAGGSTNEPVELAARLSRDRGVVVDIGKCTLNLPWNAY
                     YEKELDVRFSRSYGPGRYDPGYELEGRDYPIGYVRWTERRNLECFLDLVAAGRIDVEPL
                     ISHVADFAEAVRTYRRLNDGELKAVAVLFDYPRQTAAAEPATRASVRLPVPASATVSRP
                     VAAKHSPVRIAFVGAGNYASSMLLPHLAERKDVELRQVVTTSALSAANAQRKFGFATAA
                     TDIDTVLADSTVDAVFVVTRHSSHAELTRRALLAGKAVFVEKPLALSESELDDVLAAVE
                     ESGNDRLQVGFNRRFAPLLRRAKGRFGRRVGPATVRYLVNAGRLEQGSWYGKQDTEGSR
                     FAGEGGHFVDTVSWLLDGDPVSVYACATPGQDDLQVMLRYPDGSTATITYATTGAASFP
                     KETLDVIADGKVLKFDDFQRAAFFGRKRSASPKLPRGRDKGQRAELDAFVDAVRTGGPM
                     PVPVASLARTTLATLAVRTSLATGAPVRLDAPSVAAPTVPALVGSRTPR"
     gene            2796..4802
                     /locus_tag="BM199_RS06475"
                     /old_locus_tag="SAMN05216266_10359"
     CDS             2796..4802
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152293.1"
                     /locus_tag="BM199_RS06475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10359"
                     /product="alginate lyase family protein"
                     /protein_id="WP_091671573.1"
                     /transl_table=11
                     /translation="MSPGWYLRRLSRMGPREIAGRVTDVVRRHRWRSVADNPGFAGTGT
                     PWLANLRFTAVLDSRVMAGAPADAAARLLATAEELMDGRAEYFGVVRDDLVSPDWSLDP
                     RTGRRAPADAYTFDIPYRDEEAVGDIKQIWEPSRHQHLTVLAAAYARTGDERFAERVAD
                     HLKSWWAANPPLRGVHWTSGIELGIRLLSWVWVRRLLDDWPGAAGLFEENPEALHQIRQ
                     HQRWLAAFPSRGSSANNHVIAEAAGQLAAACAFDWYPESARWRAQALKSLYTQLRKNTF
                     DSGLNRELATEYHGLVLELGMAAAAEAHAAGVEVPLSMWSVLLRMTDALAAVLDSRLRP
                     PRQGDADDGHGLIVDGAGTDRWGSLLATGDAWFGRLNWWPSAPESDIRTALLTGLATAV
                     PVPAAVGRPLRRPDHFADAGLTILRSAAGDPRGEIWCRCDGGPHGFLSIAAHAHADALS
                     VEVRHDGIDILADPGTYCYHGEPRWRAYFRSTLGHNTLELEGQNQSTSGGPFLWTRHAR
                     SRVLVTEQPPEGVARWRAQHNGYSRRRRATIHRRTVEFDTAERELRILDEVREGGPECR
                     LAFHIGPRIEVQLAGTTARLGWVPVDGGARREAVLELPPTLTWSAHRGETDPPLGWYSA
                     GFGRKVPACTLVGTGRTSKEETAALATLLRFQA"
     gene            4861..6342
                     /locus_tag="BM199_RS06480"
                     /old_locus_tag="SAMN05216266_10360"
     CDS             4861..6342
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417468.1"
                     /locus_tag="BM199_RS06480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10360"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_091671122.1"
                     /transl_table=11
                     /translation="MAAFGALSLLVLTACSPREPAPRTPEPVRIAAVCDATQPGPAQPP
                     DGAVRVDPAVPGDLIDKTEASPAGTTFWLSAGEHSLGTGRYSQVAPKQGNTYLGAPGAV
                     LEGGQVNQYAFTGDAADVTIRHLTVQGFVPPHNEGVVNHDSADGWVLEHNTIQHNGGAG
                     LMAGARQQVRGNCLRENGQYGINAYKAGNTITGLVVEGNEIVGNNTDDWESRIEGCGCT
                     GGVKFWAVNGADVVGNWVHDNRGVGLWGDTNNNDFLIAGNLIERNDSTAIFYETSYNAV
                     IRDNTIRANNWVEGRTFAERGDSFPAATIYLSESGGEPRIPARTDRIEIVGNVLEDNWS
                     GITLWENADRFCNSPANTSSGSCTLLVDDPATCSAPGIETEPLLSDCRWKTQRVEIHGN
                     RFTLDPAVVGCTVSCGRMALLSNFGTYPDWSPYVDETVQESITFEQDNQWHDNTYVGPW
                     SFMPTDTSQVLEPEQWQTPPYRQDQGSTFAPNGGG"
     gene            6383..7579
                     /locus_tag="BM199_RS06485"
                     /old_locus_tag="SAMN05216266_10361"
     CDS             6383..7579
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030949.1"
                     /locus_tag="BM199_RS06485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10361"
                     /product="hypothetical protein"
                     /protein_id="WP_091671574.1"
                     /transl_table=11
                     /translation="MTAVAAGGRGTTPRQVGLIWALLVLNTLGSTGAVTVVPIPRLVTQ
                     VLTMGALVLAFGLALLINTRLRVRPSAYLLLLTLMVLVSVIASANLESGFGALFRCARF
                     AMFVGTLWLLTRWWDGTLTFVRHHIRVLAVVLLTVGLGALISPGLAFPDSYGGRLVGAL
                     WPLTAPQVGQYAAITAGLTLLLWLARRTDGRSAALIALPAIGMLLLSHTRTAAVGLVAA
                     LLAGGLSLTLTSARARKVFTWGVAVAGVAAVAAGPAVQAWFQRGQTEENFTNLTGRAKV
                     WDALLAAPRTTSEYVFGVGLTDKSFDGLPIDSSWLAVYHEQGYLGVAILVAFLLTLVVV
                     AALRPPSVSRSCAIFLIVYCLTTSYTEAGLGDASPYLLHLAVACALLARPATSEVVRA"
     gene            7591..8826
                     /locus_tag="BM199_RS06490"
                     /old_locus_tag="SAMN05216266_10362"
     CDS             7591..8826
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152290.1"
                     /locus_tag="BM199_RS06490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10362"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_091671576.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.5e-32,
                     bitscore: 107.1, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLVVHNRYRSEQPSGENNVVDQETALLAGAGHRVESFERRSDD
                     IAAMSLFGKATVPVRVPWNPAVRAELTALLRARRPDIVHIHNTFPLLSPSVLAACADAG
                     VPAVATLHNYTMTCAPGTLYRDGRVCTDCVGGSPLPAVRNGCYRGSRLATVPLAIGMAA
                     NRERWWSGVARFFCISDAQRQILVHAGMPEQRLAVKHNFVTDPGAVRTGPGEHVLYLGR
                     LTEEKGVRLLMTAWDAVRDRSAPRVPLVLAGTGPLEDEVRRWADGRADVRYLGLRDKAE
                     CRELAARAMAMVAPSTWLETFGLVVVEAMAAGVPTVAAAHGAFVELVADGRTGLLHRPG
                     DPVALANCLRRVLVDPAAARDMGTAARLRYEEGFTPAVGLRRLIAGYESVLSEAPAETG
                     GEAGGHGTQTVR"
     gene            8804..9928
                     /locus_tag="BM199_RS06495"
                     /old_locus_tag="SAMN05216266_10363"
     CDS             8804..9928
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.4"
                     /locus_tag="BM199_RS06495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10363"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_091671124.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.6e-39, bitscore:
                     130.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARRLCDEDNYPAALLAVAGYGLAEATRPFPTAALDDAAWDRLLE
                     AARTHRLIGQLRAAADAGTMPATREQTARVRTAHRSILLRVLSLEAELVGVAELLGAAG
                     VEFRVLKGSSFAQLDYPQTALRSFIDLDILVRADDIDHAVAALTEAGFARTLAQPRPGF
                     DRRFDKGTTLRNPKGFELDLHRTFVLGPWGVLVDLAELWREGETFGVGGRTLTALSRPN
                     RFLHACYHAALGDWPLRLGSLRDVAQLLPHTDAEGAALIGTAERWGVRAVVAAAVADAT
                     RLLGLELSCAFTEWARTYVPNRQEEGWLALHTHAHKTFAAQAIATVPVLPSLRDKAAYL
                     RALVLPDTRYTEGRHASALSRFRFALREARRGRG"
     gene            complement(10001..11146)
                     /locus_tag="BM199_RS06500"
                     /old_locus_tag="SAMN05216266_10364"
     CDS             complement(10001..11146)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986483.1"
                     /locus_tag="BM199_RS06500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10364"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_245788194.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.7e-16, bitscore:
                     55.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVYAMDPLEIAGGWVNGYDDVPFPSAAGDGPRRVLDRLLVRHLR
                     RSPCLVAFSGGRDSSVVLAAAVAAARREGLPLPIPVTLTYPDAPKSNEAEWQHAVLDHL
                     GIAERVTLTVHDEHDPIGPIAAPLLRRHGIVWSPNFAPTWRMMDLARGGVLLTGEGGDE
                     LFGLKRITPLTKSIKARGRVRPGVYQDVVRALAPARTRSHTALRQRYRRPWLRAPVEAL
                     LARRDAADAAAYALHAGRNAWQFTIRRCARRSYESIRVLGAEIDVEYVQMFAEPELVVS
                     VATAAGFWGWSGRTATMRHLFDDLLPQAVFERGTKAVFTNAVFTEHAREFARGWTGGGV
                     DPELVDPEALRANWLSHTPHAPSMALLQQAWLASDRAARSA"
     misc_feature    11168..11185
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.46"
                     /tool="antismash"
     gene            complement(11229..11369)
                     /locus_tag="BM199_RS33765"
                     /old_locus_tag="SAMN05216266_10365"
     CDS             complement(11229..11369)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986482.1"
                     /locus_tag="BM199_RS33765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10365"
                     /product="hypothetical protein"
                     /protein_id="WP_177242497.1"
                     /transl_table=11
                     /translation="MRKPYEAPEISMLGSVTELTQANLFGKEADSLTWILPILGDDDNY
                     S"
     misc_feature    11360..11375
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     misc_feature    complement(11447..11460)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.79"
                     /tool="antismash"
     misc_feature    11448..11461
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.17"
                     /tool="antismash"
     misc_feature    11604..11616
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.42"
                     /tool="antismash"
     gene            11763..13553
                     /locus_tag="BM199_RS06505"
                     /old_locus_tag="SAMN05216266_10366"
     CDS             11763..13553
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417453.1"
                     /locus_tag="BM199_RS06505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10366"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_091671130.1"
                     /transl_table=11
                     /translation="MHPVRILKSATATPRLIVAAAGEVGRADRAGALVASVYQVIGAGS
                     ALGVVAAGKLTFDALLTPEQAALGLTPSILLLALMTALSGSIGPLQTQQHRLLGERVSQ
                     RVWDRVLDTTARADLVTYESSGFATALERVQQHALTRPFAVTTSLLGLSGSLLGVGAMS
                     AVLIGVEPLLVPILLAAGLPAVLLSRWASRTEFSFAHRLTGLFRRRNYLRQLLTQRPFA
                     AELRAFDSTGPLRRRHQAGNDEINSALRKQVRRRQLIATLTTLGVAAALTGALLAIIEL
                     VERGRIGLAEAGAAAIAVRLLSGQLTTFFRSIGGLLESAPFLADLERFVASGPPAPPKG
                     NKRALAEGVRLDGVSFRYPGQDRSAVDSVDIEIHAGEVVALVGENGSGKTTLAKIVAGL
                     YEPEEGTRHWDGSAVPAPDVRASTTVIFQDFVRYQMTLRENIVISDGSRSADTEAENDR
                     AVEAARQAGVLGAARRLADGMDTMLGRDLDEGVDLSGGQWQRVALARALYRDTPLVVLD
                     EPAAALDPRAEHELFADVRATLGGRAALLISHRFSSTRMADRIYVMDDGRVVECGTHDE
                     LMASAGQYAELYRLQSAAYR"
     gene            complement(13650..14621)
                     /locus_tag="BM199_RS06510"
                     /old_locus_tag="SAMN05216266_10367"
     CDS             complement(13650..14621)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417452.1"
                     /locus_tag="BM199_RS06510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10367"
                     /product="hypothetical protein"
                     /protein_id="WP_245788195.1"
                     /transl_table=11
                     /translation="MTAAMAFHYRAHGLAVSSEAELPLSPAPPPAGRPDFVLRVGEDAP
                     VPEERPEGELLAALNRRNGTVFYTLVRRDDHTILRYPGVCDFVGDHELARVSAHWDPAA
                     DRGLLPVLAAGALLAVHLTLRGHLVLHASAVQLDGRALAFVGASGMGKSTLAAALCGTG
                     CALVADDVLRVDVIGAAAARVYPGSTENRLRAAARELADSAPAGAARPTADGRLSLRPA
                     AVADGPLPLAACVVPRPSREAVEVGVHRLSPARALLRLSQFPRVLGWRDPATMGDSFQA
                     LADLVERVPVAEAVIPWGPPFRPEVLTGLLDAVRSPAVPLSR"
     gene            complement(14618..15040)
                     /locus_tag="BM199_RS06515"
                     /old_locus_tag="SAMN05216266_10368"
     CDS             complement(14618..15040)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986478.1"
                     /locus_tag="BM199_RS06515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10368"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_245788196.1"
                     /sec_met_domain="PF13471 (E-value: 1.4e-12, bitscore: 42.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPRRRVRLVLELLLAVSAMMLIEISLRTSDLPTTCRRLGVGWDL
                     TSAAPAAARHAVLPRRTRPTVGVACFVVSRWPAGDTCLRRCLLIGYRLRNLGPVLRIGV
                     RRDANGEFSAHSWLEIDGASLDPAASAYAALGSARR"
     gene            complement(15042..15293)
                     /locus_tag="BM199_RS06520"
                     /old_locus_tag="SAMN05216266_10369"
     CDS             complement(15042..15293)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017986476.1"
                     /locus_tag="BM199_RS06520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10369"
                     /product="PqqD family protein"
                     /protein_id="WP_091671135.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.8e-21,
                     bitscore: 69.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3e-17, bitscore: 57.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRTAEVSARTIGDETIILNLPTSRYFTITGVGTRVFELLAEDT
                     SVDELVETIIAEYEVEPAVARRDIELFLDRLRDAELLH"
     aSDomain        complement(15048..15281)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BM199_RS06520_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.00E-22"
                     /identifier="RREFam002.1"
                     /label="BM199_RS06520"
                     /locus_tag="BM199_RS06520"
                     /protein_end="82"
                     /protein_start="4"
                     /score="69.4"
                     /tool="antismash"
                     /translation="TAEVSARTIGDETIILNLPTSRYFTITGVGTRVFELLAEDTSVDE
                     LVETIIAEYEVEPAVARRDIELFLDRLRDAELL"
     gene            15424..16095
                     /locus_tag="BM199_RS06525"
                     /old_locus_tag="SAMN05216266_10370"
     CDS             15424..16095
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222488.1"
                     /locus_tag="BM199_RS06525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10370"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_245788197.1"
                     /transl_table=11
                     /translation="MISPPVDSLPASPAVPAPLRLPLGLLATLAALAMLTLGLYYSGHS
                     SPGDLDRTLMSAAGEPAEPARTLALFVDFGGEPVGAVILVTVLGVLCLALRRVRLAVLA
                     LAGPALTVIATTLLKPVFGRTINGEHLSYPSGHTAMAAALAVVFLLLIVQLFEISRIPG
                     TALVLAGSAVAGAEMAWSQVALGAHYPTDTIGGYCTALAVTPLTALALDRVGVSSPARR
                     R"
     gene            complement(16070..17563)
                     /locus_tag="BM199_RS06530"
                     /old_locus_tag="SAMN05216266_10371"
     CDS             complement(16070..17563)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020638219.1"
                     /locus_tag="BM199_RS06530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10371"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_091671138.1"
                     /transl_table=11
                     /translation="MVRRCAAVLVALCVVQTVLVSPPAAVADGPGPTAPCDNQPANHST
                     PPAGAVTVRPEVDNDLHAKTAAGPAGTTFWLAPGTHTLGDDEFGQVIPKDGNVYLGAPG
                     AVLDGRGLNRFAFTQRAENVVIDGLTIQGFVAPQDQGVVNHDSGDGWVIRNSTIQHNRG
                     AALMAGARQVIRHNCLRENGQYGINAYQEGDTITDLVVEANEISGNNTDDWETKVPGCG
                     CSGAMKFWAVDGADIRDNWIHHNHGAGLWADTNNNDFLVEGNLFEDNEAEAVFYEISYN
                     LVLRENTFRRNTLVQGTRFAERGDNFPVGTVYLSEAGGEPRVPARTDRIEIHGNVFEDN
                     WSGITLWENADRFCNSPANTSSGYCTELVESRATCTRPGIASAPLYDDCRWKTQRVDIR
                     DNTFRFDPARVDCDGDLCGRMAVLANYGTYPDWSPYHGHGVAEAITFGQDNRWHGNTYT
                     GPWRFLAHDTSRALTPEQWRSEPYGQDTCSSFTGGAPDC"
     misc_feature    17550..17564
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.29"
                     /tool="antismash"
     misc_feature    17606..17617
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.05"
                     /tool="antismash"
     gene            complement(17778..19112)
                     /locus_tag="BM199_RS06535"
                     /old_locus_tag="SAMN05216266_10372"
     CDS             complement(17778..19112)
                     /EC_number="5.4.3.8"
                     /NRPS_PKS="Domain: Aminotran_3 (46-344). E-value: 4e-39.
                     Score: 126.5. Matches aSDomain:
                     nrpspksdomains_BM199_RS06535_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643146.1"
                     /locus_tag="BM199_RS06535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10372"
                     /product="glutamate-1-semialdehyde 2,1-aminomutase"
                     /protein_id="WP_091671140.1"
                     /sec_met_domain="Aminotran_3 (E-value: 9.3e-36, bitscore:
                     117.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPDRPDSTLPRSTAANARLHELIPGGAHTYAKGDDQYPDGMAP
                     VISHGHGAHVWDIDGNSYIEYGSGLRSVSLGHAHPRVLEAVRRELGRGANFVRPSILEL
                     DAAEQFLATVPTAEMVKFAKNGSDVTTAAVRLARAATGRPLVAICGDQPFFSTDDWFIG
                     TTPMPAGIPGRTTELTVNFPYGDLAATEALLREHDGQVACLMLEAAGQQEPPPGYLAGL
                     RSLADRFGCVLIFDEMITGFRWSEAGAQGLYGVVPDLSTFGKALGNGFAVSALAGRRAL
                     LEQGGLRDSRERVFLLSTTHGAETHSLAAAMAVLRTYLEEGITARLHALGERLAAGVRE
                     VAAGMGVGEHVVVRGRASNLVFATLDGELRPSQEYRTLFLRQLVAGGVLGPSFVVSSAL
                     SEEDIDRTVEVVAQACATYRKALDAEDPLAWTGGRPVRPVFRRFS"
     aSDomain        complement(18081..18974)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM199_RS06535_Aminotran_3.1"
                     /evalue="4.00E-39"
                     /label="BM199_RS06535_Aminotran_3.1"
                     /locus_tag="BM199_RS06535"
                     /protein_end="344"
                     /protein_start="46"
                     /score="126.5"
                     /tool="antismash"
                     /translation="ISHGHGAHVWDIDGNSYIEYGSGLRSVSLGHAHPRVLEAVRRELG
                     RGANFVRPSILELDAAEQFLATVPTAEMVKFAKNGSDVTTAAVRLARAATGRPLVAICG
                     DQPFFSTDDWFIGTTPMPAGIPGRTTELTVNFPYGDLAATEALLREHDGQVACLMLEAA
                     GQQEPPPGYLAGLRSLADRFGCVLIFDEMITGFRWSEAGAQGLYGVVPDLSTFGKALGN
                     GFAVSALAGRRALLEQGGLRDSRERVFLLSTTHGAETHSLAAAMAVLRTYLEEGITARL
                     HALGERLAAGVREVAAG"
     gene            complement(19109..19687)
                     /gene="rfbC"
                     /locus_tag="BM199_RS06540"
                     /old_locus_tag="SAMN05216266_10373"
     CDS             complement(19109..19687)
                     /EC_number="5.1.3.13"
                     /GO_function="GO:0008830 - dTDP-4-dehydrorhamnose
                     3,5-epimerase activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="rfbC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030957.1"
                     /locus_tag="BM199_RS06540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10373"
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase"
                     /protein_id="WP_091671143.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 2e-54, bitscore:
                     178.3, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVTEVPAIAGAYLFEPAPHADERGFFARTFDREVVRSVGIDPDG
                     FVQDSLSRSALGVLRGMHLRSGAGEAKLVRCSAGEVFDVVVDLRPDSPTYLNKEYFELS
                     GQTQVTLYVPAGCAHGFQALTDPADVSYRIDRPHDPAEDVTISWADPELAIPWPLPVSM
                     MSERDRQAPSLADVLDRLRREFVTAEVSP"
     gene            complement(19684..20916)
                     /locus_tag="BM199_RS06545"
                     /old_locus_tag="SAMN05216266_10374"
     CDS             complement(19684..20916)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030958.1"
                     /locus_tag="BM199_RS06545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10374"
                     /product="polysaccharide pyruvyl transferase family
                     protein"
                     /protein_id="WP_245788198.1"
                     /transl_table=11
                     /translation="MTGPRIGLFGLFGSGNMGNDGSLDAVLSHLRGQYPDAVFDCLCPE
                     PEEVTRRFAIPATQLHWYDARPRPTSNIAASALKVVGKIADLARTVRWTRRFDVVIVPG
                     MGVLETTLPLRPWGFPYALFLLCASGKLVGTRVALVNVGANVIGQRLTRWLSTSSARLA
                     YYRSFRDALSRQAMREMGVDTSRDLVYPDLVYALPAPEPTSPEPGTIGVGVMDFHGGND
                     DREHAGEIRSNYADAMVRFVHRLLDAGHGVRLFTGDRVDEVVVAEILGDVCRTRSETDS
                     ARVIAEPVTSLPELMRQMTTVDSVVGTRYHNVVCAVKLGKPTISISYSAKSDQIMIDMG
                     LGEFCQSARAVDVELLMKQLDVLEKQREQLRRGMLERGAEYSRELERQFRDLCERLFPG
                     TEGTFQVEEAR"
     gene            complement(20913..21866)
                     /locus_tag="BM199_RS06550"
                     /old_locus_tag="SAMN05216266_10375"
     CDS             complement(20913..21866)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152283.1"
                     /locus_tag="BM199_RS06550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10375"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_091671145.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 5.8e-31,
                     bitscore: 102.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVPRLSIGLPVYNGAEYLAEALDALLGQSFRDFELIISDNAST
                     DETESICRRYAEEDSRIRYIRLPKNIGAAPNHNFVFTEAKGEYFKWASHDDLYGRELLR
                     RCVETLDADPEVVLAHSWNAIIDNTGAVTEPFDYSMATDSPHAPERFRSLLFAPGGDDF
                     YGVIRADALRRVAPHDSYHHADRTIVAEIALHGRFHQVPELLYFRRDHPTRAERANPTK
                     RSRCANLDPRRADPVRHPTVRLLGEYVLGFIGTIRRAPLTSAQRRECYRYLAQWLVSRA
                     VPWRRDAVPEPAAPAELDSLSGTVDAVVPGRHRRTS"
     gene            complement(21874..23145)
                     /locus_tag="BM199_RS06555"
                     /old_locus_tag="SAMN05216266_10376"
     CDS             complement(21874..23145)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417443.1"
                     /locus_tag="BM199_RS06555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10376"
                     /product="hypothetical protein"
                     /protein_id="WP_091671148.1"
                     /transl_table=11
                     /translation="MRAVAGRISWGLADQAVSSMTNFAVGIYVARTLGVTEFGVFTLAW
                     VTYGLVLNISRGLTTDPLVVRFSGVSPAAWRAAVARSSGTALLIGLVSGVVSVLAGLAI
                     GGGLGAAFVALGLVFPMLLLQDSWRFAFFAAGQGRKAFVNDVVWGAALIPALVLAAQQG
                     SVFWFVLAWGVSGGVAAGFGYLQSGVVPAGVQAAVWLRQQRDLGPRYLVENVSNSGASQ
                     LRMYGLGAIAGLSEVGAIRGAELLLGPFLAVLMGLSLVAVPEAARVLRRSPHRLPKFCL
                     VLGGSQAAAALVWGCALLLVPDIAGEFVLDSVWEPASALILPVTLSVTGAGLVAGAASG
                     LRALGAARRSLRSQLIASAGYLGGGLAGATIAGALGASWGSAIAMWCGAAIWWGQLRVA
                     HREHQAGIHATSDESLEETEEFTR"
     gene            complement(23232..24497)
                     /locus_tag="BM199_RS06560"
                     /old_locus_tag="SAMN05216266_10377"
     CDS             complement(23232..24497)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643151.1"
                     /locus_tag="BM199_RS06560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_10377"
                     /product="DUF4910 domain-containing protein"
                     /protein_id="WP_177242498.1"
                     /transl_table=11
                     /translation="MHELVERLYPLCRSITGDGVRRTLEILSEHIPLRVHEVPTGTPVL
                     DWTVPQEWNIRDAYIADSAGNRVVDFADSSLHVVSYSVPVSATMTLQQLRSHLHTLPEH
                     PSWIPYRTSYYAPDWGFCLAQNTLDAMPDGDYEVHIDSTLGDGHLTYGEYVVPGQVADE
                     VIVSCHVCHPALANDNLAGIAVATALAGELAAAAPHHTYRFLFVPGTIGSITWLARNFE
                     RVDRIRHGLVLACAGDRGSLTYKQSRRGDAEIDRVLRHLLRASGRPHEIVRFSPYGYDE
                     RQFCSPGFNLGVGSLTRTPHAGYPEYHTSADNPDFVLAESMSDTLATCREAFAVLDRNR
                     TYVNLSPYGEPQLGRRGLYDSLGGRSDAKQAQLAMLWVLNLSDGEHSLLDVADRAELPF
                     DTVVAAADALRDAGLLKEADGT"
     misc_feature    complement(23271..23273)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    24456..24473
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
ORIGIN
        1 gcggacagcc ggttgttcct gcccggcctg aacctcgcgt acaccgacag gtcgagcatg
       61 gccgcgtcga ccgaggtgcg agtgccgttc gtcgacgtcg aggtggtcag ggccgcgttc
      121 gccacccccg gaaaccgcaa gatcgtcggc cgcaggggaa aggtcgcgct caaacaggcg
      181 gcgacgtcga tcctgccgga cgagatcgtg caccggccga agggcctgtt cagcgcgccg
      241 ctgcgggcgt ggatgagtcg ggacctcgca ccgctggtgc aggaggtcat ccacgacggc
      301 gcgctggtga actccggctt cctgcggcgc gaggcgttgc agcggctggt cgccgaggac
      361 gccgcgggca ggcaggacag ggccaagcac ctctggcaca tcctcacgtt ggagtactgg
      421 tatcgcggcg ccacagccgc cggtgccggt gagtgaacac tttcccggga aagtgcggga
      481 ctggagacgt tccgtcgcag gtcgcggggt tggtttctcg cactttcccg ggaaagtgcg
      541 agacagggaa aacagggagc agcagtgaag caggtcgtac agaactacaa gagtggcgag
      601 ctgacgctca tcgatgttcc tgagcccgcg tgcaagccgg gtggggtgct ggtgcgcaca
      661 gacttctcgc tgatctccac cgggaccgag atgatgaagg tctccgaggc gagcatgtcc
      721 atgctgggca aggcgaaggc ccggccggac caggtcgcca aggtcatgca gagcgtggcg
      781 ggcaacggtc tcgcggcgac ctaccggaag gtgaacaaca agctcgactc ctacaccccc
      841 ctcggctact ccctgtgtgg cgtggtggag gaggtcggcg ccggtgccga cgtgtccgtc
      901 ggcgatatcg tcgcgtgcgc gggaaacgaa cacgcgctgc acgccgagct gaactgggtg
      961 ccccgcaacc tgtactcgcg cgttcccgac ggggtggatc cccgtcacgc cgctttcggc
     1021 accgtcggcg cgatcgcgat gcagggggtc cggcgtggtg agccgcagct gggggaactg
     1081 gcgctggtca tcggcctcgg gctgatcggg cagttggtcg tgcagttgct gaccgccgcg
     1141 ggggtccggg tggtcggtgt cgacccggac ccggatcggt gcgcgctggc cgaacgcctc
     1201 ggggcgctgg tctgcagcgc ccccggttcg ggcgtggtgg actcggccgt cggcgagctc
     1261 tccggcggtc acggcgtcga tcaggtgtac ctggcggcgg gcggcagcac caacgagccg
     1321 gtggagctgg ccgcgcggct gagccgggat cgcggcgtgg tggtggacat cggcaagtgc
     1381 accctcaacc ttccgtggaa cgcctactac gagaaggaac tggacgtccg gttctcccgc
     1441 tcctacggcc ccggccgcta cgaccccggg tacgagctgg agggccgaga ctacccgatc
     1501 ggctatgtcc ggtggaccga acggcgcaac ctggagtgct tcctcgacct cgtcgcggcg
     1561 ggccggatcg acgtcgagcc gctgatctcg cacgtcgcgg acttcgccga ggcggtgcgg
     1621 acctatcgga ggctcaacga tggcgagctg aaagcggtgg ccgtgctgtt cgactacccg
     1681 cggcagacgg cggcagccga acccgctacc cgggcttccg tgcgactgcc ggttcccgcg
     1741 tcggcaacgg tgtccaggcc ggtcgcggcg aagcactcgc cggtgcggat cgcgttcgtc
     1801 ggagcgggca actacgcctc gtcgatgctg ctgccgcatc tggcggagcg caaggatgtc
     1861 gagctgcgcc aggtggtcac cacctcggcg ctgtccgccg ccaacgcaca gcgcaagttc
     1921 ggcttcgcca ccgccgccac cgacatcgac acggtgctcg ctgattccac tgtggacgct
     1981 gtgttcgtgg tgacccggca cagttcgcat gccgagctga cgcggcgcgc gctgctcgcg
     2041 ggaaaggccg tgttcgtcga aaagccgctg gccctcagcg agtccgaact ggacgatgtc
     2101 ctggccgctg tcgaggagtc cggcaacgac cggctacagg tcggtttcaa ccgccgcttc
     2161 gcgccgctgc tgcgcagggc caagggccgc ttcggcaggc gtgtgggtcc ggcgacggtg
     2221 cgctacctgg tcaacgcggg ccggttggag cagggcagct ggtacggcaa gcaggacacc
     2281 gagggttccc ggttcgccgg tgagggcggg cacttcgtcg acacggtcag ctggctgctc
     2341 gacggggatc cggtttcggt gtacgcctgc gccactccgg gacaggacga cctgcaggtc
     2401 atgctgcgtt atccggacgg gtccacggcc acgatcacct acgccaccac cggtgccgcg
     2461 agcttcccga aggagaccct cgacgtgatc gccgacggca aggtgctgaa gttcgacgac
     2521 ttccagcgtg ccgcgttctt cggccgaaaa cgttcggcga gtccgaaact tccgcggggg
     2581 cgggacaagg gccagcgtgc ggaactcgac gcgttcgtcg acgcggtacg gaccggcggg
     2641 ccgatgccgg tgcccgtcgc gtcgctggcc aggaccacgc tcgccacgct cgcggtgcgg
     2701 acgagtctgg ccacgggtgc gccggtccgc ctcgacgccc cttccgtcgc ggcgcccacc
     2761 gtccctgcgc tcgtcggcag caggacaccg cgatgatgtc gccggggtgg tacctgcggc
     2821 gcctgtcccg aatgggaccg agggagatcg cgggtcgcgt gaccgacgtg gtgcgcaggc
     2881 accgttggcg gtccgtggcc gacaatcccg gtttcgcggg cacaggcacg ccctggctgg
     2941 cgaacctgcg gttcaccgcc gtactggact cgcgggtcat ggcaggcgcc cccgccgatg
     3001 cggctgcgcg cctgctcgcc acggcggagg agctgatgga cggtcgggcc gagtatttcg
     3061 gcgtcgtccg cgacgacctg gtctccccgg actggtcgct ggatccgcgc accggaaggc
     3121 gggcacccgc ggacgcctac accttcgaca tcccgtaccg ggacgaggag gcagtcggtg
     3181 acatcaaaca gatctgggaa ccgtcacggc accagcacct gacggttctc gccgcggcct
     3241 acgcacgcac cggggacgag cggttcgccg agcgggtggc cgaccacctc aaatcgtggt
     3301 gggcggcgaa cccgccgctg cgcggggtgc actggaccag cgggatcgag ctgggcatcc
     3361 ggttgctgtc gtgggtgtgg gtgcgcaggc tgctcgacga ctggcccggt gccgcgggtc
     3421 tgttcgagga gaaccccgag gcgctgcacc agatccggca acaccagcgc tggctggcgg
     3481 ccttccccag ccggggctcc tcggccaaca accacgtcat cgcggaggcc gcgggacagc
     3541 tcgccgccgc ctgcgccttc gactggtatc ccgagtcggc gcggtggcgg gcacaggcgc
     3601 tcaagtcgct gtacacgcag ttgcggaaga acacgttcga ctccgggctg aaccgggaac
     3661 tcgcgaccga gtaccacgga ctcgtcctgg agctgggaat ggcggcggcg gccgaggccc
     3721 acgccgccgg agtcgaggtt ccgctgtcga tgtggtcggt gctgctgcgg atgaccgatg
     3781 ccctcgccgc cgtcctcgac tcgcgactgc ggccgccccg gcagggcgac gccgacgacg
     3841 gacacggcct gatcgtcgac ggcgcgggca cggaccgctg gggatcgctg ctggcgacag
     3901 gggatgcctg gttcggcagg ctgaactggt ggccgtcggc accggaatcc gacatccgca
     3961 ccgcattgct gaccgggctc gccaccgcgg tgccggtacc agcggccgtc ggccgaccgc
     4021 tgcgcaggcc cgaccacttc gccgacgcgg ggctgacgat tctgcgcagc gccgcgggcg
     4081 acccgcgggg ggagatctgg tgccggtgcg acggcggccc gcacggcttc ctctcgatcg
     4141 ccgcgcacgc gcacgccgac gcactgtcgg tcgaggtgcg ccacgacggg atcgacatcc
     4201 tcgccgatcc cggcacgtac tgctaccacg gtgaaccgcg ctggcgggcg tacttccggt
     4261 ccacgctcgg ccacaacacg ctggagctgg aggggcagaa ccagtccaca tcgggcggtc
     4321 cgttcctgtg gacacggcac gcccgaagcc gggtgctcgt cacggagcag ccgccggaag
     4381 gggtcgcccg ctggcgtgcc cagcacaacg gctactcgcg caggcggcgt gccacgatcc
     4441 accgccgtac cgtcgagttc gacaccgcgg agcgcgaact gcgcatcctc gacgaggttc
     4501 gcgaaggcgg gccggagtgc aggctcgcgt tccacatcgg accccggatt gaggtgcaac
     4561 tcgccgggac caccgcccgg ctcggctggg tccccgtgga cggtggcgcg aggcgggagg
     4621 ccgtgctcga actgccgccg acgctgacct ggtcggcgca ccgcggcgag acggatcccc
     4681 cgctgggctg gtactcggcg ggcttcggcc gcaaggtccc cgcctgcacg cttgtcggaa
     4741 ccggccggac gagcaaggaa gaaaccgcag cactggcaac cctgttgcgg ttccaggcat
     4801 aggcccgccc acccgagaag agacgacacc gtgcgccgac cgagaagaca cgccacgccg
     4861 atggcggcgt tcggtgcgct gtccctgctg gtgctcaccg cgtgctcgcc ccgggaaccc
     4921 gcgccacgga cgcccgaacc cgtccggatc gccgctgtct gcgacgcgac ccaacccggc
     4981 cccgcacagc cacccgacgg tgcggtaagg gtggacccgg ccgtaccggg tgatctcatc
     5041 gacaagaccg aggccagtcc ggcgggcacc actttctggc tatccgcggg cgagcattcc
     5101 ctcggcaccg gccgctactc gcaggtcgca cccaagcagg gcaacaccta tctcggcgct
     5161 cccggtgccg tcctcgaagg cggccaggtc aaccagtacg cgttcacggg ggacgcggcg
     5221 gacgtcacga tccggcacct cacggtccag ggtttcgtcc cgccgcacaa cgagggcgtg
     5281 gtcaaccacg actccgccga cggctgggtg ctcgaacaca acaccatcca gcacaacggc
     5341 ggtgcggggc tgatggcagg cgccaggcag caggtccgcg gcaactgcct gcgggagaac
     5401 ggccagtacg gcatcaacgc ctacaaggca ggcaacacca tcaccggcct ggtggtggag
     5461 ggcaacgaga tcgtcgggaa caacaccgac gactgggaga gccggatcga gggctgtggc
     5521 tgcaccggcg gggtgaagtt ctgggcggtg aacggcgccg acgtcgtcgg caactgggtg
     5581 cacgacaacc ggggcgtcgg gttgtggggc gacacgaaca acaacgactt cctgatcgcc
     5641 ggcaatctga tcgagcgcaa cgacagcacc gcgatcttct acgagaccag ctacaacgcg
     5701 gtgatccggg acaacaccat ccgcgccaac aactgggtgg agggccggac gttcgccgaa
     5761 cggggcgaca gtttccccgc agcgacgatc tacctttccg agtcgggggg cgaaccccgg
     5821 atcccggccc gcaccgacag gatcgagatc gtcggcaacg tcctggagga caactggtcg
     5881 ggcatcacgc tgtgggagaa cgccgaccgg ttctgcaaca gcccggccaa cacctccagc
     5941 ggttcgtgca cactgctcgt cgacgacccg gccacatgtt ccgcgccggg gatcgagacc
     6001 gagccgctgc tcagcgactg ccgctggaag acccagcgcg tggagatcca cggcaaccgc
     6061 ttcaccctcg accccgccgt cgtcgggtgc acggtgagct gcggccggat ggcactgctg
     6121 tcgaacttcg gcacctaccc ggactggtcg ccctatgtgg acgagaccgt ccaggagtcg
     6181 atcaccttcg agcaggacaa ccagtggcac gacaacacct atgtcggccc gtggagcttc
     6241 atgcccaccg acaccagtca ggtgctcgaa ccggagcagt ggcagacccc gccgtaccgg
     6301 caggaccagg gcagcacctt cgctccgaac gggggtggct gaggtgagca cggacgacac
     6361 cacgcaccgg cagggcggga ccgtgaccgc cgtcgcggcc ggcggacggg gaaccacacc
     6421 gcggcaggtc gggctgatct gggcgttgct ggtcctcaac acgctcggtt ccaccggtgc
     6481 cgtcacggtg gtcccgatcc cgcgcctggt cacccaggtg ctgacgatgg gcgcgctggt
     6541 gctcgcgttc gggctggccc tgctgatcaa cacccggctg cgggtgcgac cgagcgccta
     6601 cctgctcctg ctcaccctga tggtcctggt cagcgtgatc gccagcgcga atctggaatc
     6661 gggcttcggc gcactgttcc gctgtgcgcg cttcgcgatg ttcgtcggga cgctgtggct
     6721 gctcacgaga tggtgggacg gcacgctcac cttcgtgcgg caccacatcc gggtgctcgc
     6781 cgtggtgctg ctcaccgtgg gactgggcgc gctcatctcc ccgggactgg ccttcccgga
     6841 cagctacggc ggcagactcg tcggcgcgct gtggccgctg acggctccgc aggtcggcca
     6901 gtacgccgcg atcacggcgg gcctgaccct gttgctctgg ctcgcgcggc gcaccgatgg
     6961 ccgcagcgcc gcgctgatcg cccttccggc gatcggcatg ctcctgctca gccacacgcg
     7021 aacggccgcc gtcgggctcg tcgccgccct gctggcaggc ggcctctccc tcaccctgac
     7081 cagcgcccgt gcccgcaagg tgttcacctg gggcgtcgcc gtggccgggg tcgccgccgt
     7141 ggcggcgggc cccgcggtcc aggcctggtt ccagcgtggc cagaccgagg agaacttcac
     7201 caacctcacc ggcagggcga aggtgtggga cgccctgctg gccgcacccc ggacgacgag
     7261 tgagtacgtg ttcggcgtcg gcctgacgga caagtcgttc gacgggctcc cgatcgacag
     7321 cagctggctg gcggtctacc acgaacaggg ctacctgggc gtcgcgatcc tggtggcctt
     7381 cctgctcacc ctggtggtgg tcgcggcgct gcggccgcct tcggtgtcgc ggtcctgcgc
     7441 gatcttcctg atcgtctact gcctcaccac gtcctacacg gaggccgggc tcggcgacgc
     7501 ctcgccgtac ctgctgcacc tcgccgtcgc ctgtgccctg ctggcccggc ctgcgacttc
     7561 ggaagtggtg agggcatgag cgaccgtccg ttgcgggttc tcgtggtgca caacaggtac
     7621 cgctccgagc agccgagcgg ggagaacaac gtcgtcgacc aggaaaccgc gctgctggcg
     7681 ggcgctggcc atcgggtcga gtcgttcgag cggcgcagcg acgacatcgc cgcgatgtcc
     7741 ctgttcggca aggccaccgt cccggtgcgg gtgccctgga acccggcggt gcgcgccgaa
     7801 ctcaccgcgc tgctgcgggc acggcgaccg gacatcgtgc acatccacaa cacgttcccg
     7861 ctgctgtcgc cgtcggtgct ggccgcctgc gccgacgcgg gcgtgcccgc ggtcgcgacg
     7921 ctgcacaact acacgatgac ctgcgcgccg ggcacgttgt accgcgacgg cagggtgtgc
     7981 acggactgcg tcggcggctc gccgttgccg gccgtccgca acggctgcta tcgcggctcc
     8041 cggctcgcca ccgtgccact ggcgatcggc atggccgcca accgcgagcg ctggtggtcg
     8101 ggagtggccc ggttcttctg catttccgac gcgcagcggc agatcctcgt gcacgcgggc
     8161 atgccggagc agcggctggc ggtgaagcac aacttcgtca ccgaccccgg cgcggtgcgc
     8221 accgggcccg gcgagcacgt gctctacctc ggcaggctca ccgaggagaa gggcgtgcga
     8281 ctgctgatga cggcgtggga cgcggtgcgc gaccggtcgg cgccgcgggt gccgctcgtg
     8341 ctggcgggca ccggcccgct ggaggacgag gtgcgccggt gggccgacgg tcgcgcggac
     8401 gtgcggtacc tgggtctgcg ggacaaggcc gagtgccggg aactcgccgc gcgagccatg
     8461 gcgatggtcg cgccgtcgac ctggctggag accttcggcc tcgtggtcgt ggaggcgatg
     8521 gcggccggtg tcccgaccgt ggccgcggcg cacggcgcgt tcgtcgaact ggtggcggac
     8581 ggccggaccg gtctgctgca ccgccccggt gacccggtgg cgttggcgaa ctgcctgcgg
     8641 cgggtgctgg tggacccggc tgccgcacgg gacatgggca ccgcggcccg gctgcggtac
     8701 gaggagggct tcacccccgc ggtggggctg cggcggctga tcgcgggcta cgagtcggtg
     8761 ctcagcgagg ccccggcgga aaccggcgga gaggcgggcg ggcatggcac gcagactgtg
     8821 cgatgaggac aactatcccg ccgcgctcct cgcggtggcc ggttacgggc tcgcggaggc
     8881 gacgcggccg ttcccgactg ccgcgctgga cgacgcggcg tgggaccggc tgctggaggc
     8941 cgcccggacc caccggttga tcggccagct gcgcgccgcc gccgatgccg ggacgatgcc
     9001 cgccacgcgg gagcagaccg cgcgggtgcg caccgcgcac cggtcgatcc tgctgcgggt
     9061 gttgtcgctg gaggccgaac tggtcggcgt cgcggagctg ttgggcgcgg ccggtgtcga
     9121 gttcagggtg ctcaagggca gctccttcgc gcagctggac tacccgcaga ccgcgctgcg
     9181 ctcgttcatc gacctcgaca tcctggtccg cgccgacgac atcgaccacg cggtcgcggc
     9241 actgaccgaa gcgggcttcg cgcgaactct cgcgcaaccc cggccgggct tcgatcgcag
     9301 gttcgacaag ggcacgacgc tgcggaaccc gaagggtttc gaactggatc tacatcggac
     9361 gttcgtgctc ggtccgtggg gtgtgctggt cgatctggcc gagttgtggc gcgagggtga
     9421 gacgttcggg gtgggtggcc ggacactgac cgccctgtcg cggccgaacc ggttcctgca
     9481 cgcgtgttat cacgcggcac tcggtgactg gccgctgcga ctgggctcgc tgcgcgacgt
     9541 cgcgcagctg ctgccgcaca ccgacgccga gggcgccgcg ctgatcggga cggccgagcg
     9601 ctggggggtg cgcgcggtgg tggcggccgc cgtcgccgac gccacccgcc tgctcggcct
     9661 cgaactgtcc tgcgcgttca ccgaatgggc gcgcacctac gtgccgaacc ggcaggagga
     9721 gggctggctg gccctgcaca cgcacgcgca caagaccttc gccgcacagg cgatcgcgac
     9781 cgtccccgtg ctcccgagcc tgcgggacaa ggcggcctac ctgcgcgccc tcgtactgcc
     9841 ggacaccagg tacaccgagg gcaggcacgc ctccgccctc tcccgcttcc gcttcgcact
     9901 ccgcgaagcc cgccgcggcc gcggctgact cggcagatcc ccggcccgag tttgcagatc
     9961 cggggcccga cttggcactt ccggcggccg agttcgcagt tcaggcgctc cgggccgccc
    10021 ggtcggacgc cagccacgcc tgctgcagca gtgccatgga cggcgcgtgc ggggtgtggg
    10081 agagccagtt cgcccgaagt gcctccggat cgacgagctc gggatcgact ccgccgccgg
    10141 tccagccgcg ggcgaactcc ctggcgtgtt cggtgaagac cgcgttggtg aagaccgcct
    10201 tggtgccacg ctcgaacacc gcctggggca acaggtcgtc gaacaggtga cgcatcgtgg
    10261 cggtccggcc gctccagccc cagaaccccg ccgccgtggc caccgagacg accagctcgg
    10321 gctccgcgaa catctggacg tactcgacgt cgatctcggc tcccagcacc cggatcgatt
    10381 cgtaggaccg cctcgcgcac cgcctgatgg tgaactgcca ggcgttcctg cccgcgtgca
    10441 gcgcgtacgc ggcggcatcg gcggcatccc tgcgcgccag cagcgcctcg accggcgcac
    10501 gcagccacgg acgccggtag cgctgccgca gcgccgtgtg cgagcgcgtc cgcgccggcg
    10561 ccaatgcccg cacgacgtcc tggtagaccc ccgggcgcac gcggcctcgc gccttgatcg
    10621 acttggtcag cggggtgatg cgcttgagcc cgaagagttc gtcaccgccc tccccggtca
    10681 gcagcacgcc gccccgcgcg aggtccatca tccgccaggt cggggcgaag ttcggcgacc
    10741 acacgatgcc gtgcctgcgc agcaacggcg cggcgatcgg cccgatggga tcgtgttcgt
    10801 cgtgcacggt cagcgtgacg cgctcggcga tcccgaggtg gtccagcact gcgtgctgcc
    10861 actcggcctc gttcgacttc ggcgcgtccg gataggtcag cgtgaccgga atcggcaggg
    10921 gcagcccctc ccggcgggca gccgccaccg cggcggccag taccaccgag gagtcccgtc
    10981 cgccggagaa cgcgaccagg cacggcgacc gccgcagatg ccgcaccagg agccggtcga
    11041 gcacgcggcg agggccgtcg ccagcggcgg aggggaacgg cacgtcgtcg tatccgttga
    11101 cccagccgcc cgcgatctcc aacgggtcca ttgcgtacac gctcacgggt tgcctttcct
    11161 ggtcccgcat ccgttcgggc ggatatgccc gcggggccgt cgtccatttc cggccccgcg
    11221 gcacaccgtc aggagtagtt gtcgtcgtca ccgagaatgg gcaggatcca ggtgagactg
    11281 tcggcttcct tgccgaacaa gttcgcctga gtcagctccg tgaccgatcc cagcatggag
    11341 atctccggtg cctcgtatgg cttgcgcatg tacacctcct cacacgcata gatcggacaa
    11401 gctcgaccct gagaccgaag gtgacttccc gtcactttcg gccccatttt cgtagagaaa
    11461 aaacacacgc gggcgatctg gctgagcact gtttcttgta caagtcgggt gatgcacagt
    11521 cgttggttca tctgctgctt gtgtctcacc cgcatacgcc cgccacgagc cggcctccgc
    11581 aagctccggc cgcctcctgt cggtcgcatt gtgcataacc ctcacggtag tggattcggg
    11641 cattcagccg atctgttaca cccgaacgca atatttacca gtcggtgacg caaccggtat
    11701 cccagtgctc agatcggttc cgtttttccg gaagtcagcc tgaacgcggc tacgctgcag
    11761 cagtgcatcc ggtcagaatc ctgaagtcag cgacggcgac gccgcgactg atcgtggccg
    11821 cggccggaga ggtgggccgg gccgaccggg caggcgccct ggtcgcctcg gtctaccagg
    11881 tcatcggggc gggatcggcg ctcggcgtgg tcgcggcggg caaactgacc ttcgacgcgc
    11941 tgctcacccc ggaacaggcc gcgctcggcc tgacaccgtc gattctgctg ctggctctga
    12001 tgaccgcact gtccggttcg atcggtccac tacagaccca gcagcaccgg ctgctcggcg
    12061 aacgtgtctc ccagcgcgtc tgggacaggg tgctcgacac caccgcgaga gcggacctcg
    12121 tcacctacga gtcgtccggc ttcgcgaccg cgctcgaacg ggtccagcag cacgcgctga
    12181 cccggccgtt cgcggtcacc acgtccctgc tcggcctctc cggcagcctt ctcggggtcg
    12241 gagccatgtc cgccgtgctg atcggcgtcg agcccctgct ggtgccgatc ctgctcgccg
    12301 cgggcctgcc cgcggtcctg ctgtcccgtt gggccagccg cacggagttc tcgttcgcgc
    12361 accggctcac cgggctgttc cggcgccgca actacctgcg gcaactgctg acgcagcgac
    12421 cgttcgccgc cgaactgcgc gccttcgact ccaccggacc gttgcgacgc aggcaccagg
    12481 caggcaacga cgagatcaac tccgcgctgc gcaagcaggt gcgccgcagg cagctgatcg
    12541 ccacgctgac caccctcggc gtggcggcag ccctcaccgg tgcgctgctg gccatcatcg
    12601 aactggtcga aaggggccgg atcggcctcg cggaggcggg cgcggccgcg atcgccgtgc
    12661 gcctgctcag cggccagctg accaccttct tcaggtcgat cggcgggctg ctcgaatcgg
    12721 cgccgttcct cgccgacctc gagcgtttcg tggcctcggg cccaccggct ccgccgaagg
    12781 ggaacaagcg tgcgctcgcc gagggtgtgc ggctggacgg cgtcagcttc cggtatccgg
    12841 gacaggaccg cagcgcggtc gactcggtgg acatcgagat ccacgcaggc gaggtcgtcg
    12901 ccctggtcgg cgagaacgga tcgggcaaga ccacgctcgc caagatcgtg gccgggctgt
    12961 acgagcccga ggagggcacc cggcactggg acggctccgc tgtgcccgcc ccggacgtgc
    13021 gggcctcgac cacggtcatc ttccaggact tcgtccgcta ccagatgacc ctgcgcgaga
    13081 acatcgtcat cagcgacggt tcccggtcag cggacaccga agccgagaac gaccgagccg
    13141 tcgaagcggc caggcaggcg ggcgtactcg gcgcggcccg gcggctggcc gacggcatgg
    13201 acaccatgct gggccgcgat ctggacgagg gggtcgacct ctccggtggc cagtggcagc
    13261 gagtcgcact cgccagggcg ttgtaccggg acaccccgct ggtggtgctc gacgagcccg
    13321 cggcagcgct cgacccgcgc gccgagcacg agttgttcgc cgacgtccgc gccaccctcg
    13381 gcggccgcgc tgcgctgctg atctcgcacc gcttctccag cacccgaatg gccgaccgga
    13441 tctacgtgat ggacgacggc cgggtggtgg agtgcggcac ccacgacgag ctgatggcca
    13501 gtgcgggaca gtacgcggag ttgtaccggc tccagtcggc cgcctaccgc tgacccgtcc
    13561 ccctcgcatt ttcccgggaa agtgcgcgac atggcgaccc cgttcccagg tcagcgccac
    13621 ccaccctcgc actttcccgg gaaagtgcgc tacctgctca ggggtacggc gggtgagcgc
    13681 acggcatcca gcaatccggt gagcacctcc ggccggaacg gcggccccca ggggatcacc
    13741 gcctcggcga cgggcacccg ctcgaccaga tccgccagtg cctggaacga gtcgcccatc
    13801 gtcgccggat cgcgccagcc gagcaccctg gggaactggc tcaaccgcag cagggcccgc
    13861 gccgggctca gccggtgcac cccgacctcg acggcctccc ggctcggccg gggcaccacg
    13921 cacgccgcca gcggcaacgg gccgtccgcg acagcggcag gtcgcagtga cagccgcccg
    13981 tcggcggtcg ggcgcgcggc acccgccggg gcgctgtcgg cgagttccct ggctgccgcc
    14041 cgcagccgat tctcggtgct gcccgggtac acgcgagcgg ccgccgcgcc gatgacgtcg
    14101 acgcgcagta cgtcgtcggc caccagcgcg catcccgtgc cgcacaacgc ggcggcgaga
    14161 gtcgacttgc ccattccgga cgccccgacg aacgccagcg cgcggccgtc cagctggacg
    14221 gcgctggcgt gcagcaccag gtggccgcgc agggtgaggt gcacggcgag cagggcaccc
    14281 gcggccagca cgggcagcag gccgcggtcg gcagcggggt cccagtgcgc gctgaccctg
    14341 gccagctcgt gatcgccgac gaagtcgcag acgcccggat accgcaggat cgtgtggtcg
    14401 tcccgccgga ccagggtgta gaaaacggtg ccgttccgac ggttcagcgc ggcgagcaac
    14461 tcaccttcgg gtcgttcctc cggcaccggc gcgtcctcgc cgacgcggag cacgaagtcc
    14521 ggtctccccg cggggggtgg tgccggggac agcgggagtt cggcttcgct actgacggcg
    14581 aggccgtgcg cgcggtagtg gaacgccatc gcggccgtca ccggcgcgcc gagcccagcg
    14641 ccgcgtacgc cgaggccgcg ggatcgaggg aggccccgtc gatctccagc caggaatggg
    14701 ccgagaactc accgttcgcg tcccgccgca ccccgatacg caacacgggg ccgaggttgc
    14761 gcagccggta gccgatcagc aggcaccggc gcaggcaggt gtcccccgct ggccagcgcg
    14821 acacgacgaa acacgccact ccgacggtgg ggcgggtcct gcgcggcagc accgcgtgcc
    14881 gcgcggcggc cggtgccgcg ctcgtcaggt cccagcccac ccccagcctg cggcacgtcg
    14941 tcggcaggtc actggtgcgc aggctgatct cgatcaacat catcgcggaa acggcgagga
    15001 gcagctccag gacgagccgg acgcgcctgc gcggtgtcat gtcagtgcag gagttcggca
    15061 tcgcgaagcc ggtccaggaa gagctcgatg tcccgccggg cgacggccgg ctcgacctcg
    15121 tactccgcga tgatggtttc gacgagttcg tcgacggagg tgtcctcggc gagcagttcg
    15181 aacaccctgg tgcccacccc ggtgatggtg aagtagcggg aggtcggcag gttgagaatg
    15241 atcgtttcgt ccccgatggt gcgggcggag acttcggcag ttcgcaggcg catggtccgg
    15301 tgtccctctc tctccgctgc ttgccggtga attcgctggt gagcgccctc gtgttacgcc
    15361 gaacggcctt ctacaccgaa acgaaaccaa ggcctgcgcc gattccggag aggtgaagct
    15421 ctcgtgatca gtcctcccgt cgacagcctg cccgcatcgc ccgccgttcc ggctccgctg
    15481 cgcctgccgc tcggcctgct ggccacgctc gccgcactgg cgatgctcac cctcggcctc
    15541 tactactccg ggcacagctc ccccggagac ctcgaccgga ccctcatgtc cgcggccggt
    15601 gaacccgcgg agccagcccg gacgctggcg ttgttcgtcg acttcggtgg cgaaccggtc
    15661 ggcgcggtga tcctggtgac cgtcctcggc gtgctctgcc tcgcgctgcg ccgcgtccgg
    15721 ctcgccgtgc tcgcactggc cggtccggcg ttgacggtca tcgcgaccac cctgctcaag
    15781 ccggtgttcg gccgcaccat caacggcgag cacctgtcct acccgagcgg ccacaccgcc
    15841 atggccgccg cactggcggt cgtcttcctg ctcctgatcg tccagctctt cgagatctcc
    15901 cggatcccgg gcacggcact ggtgctcgcg ggctccgcgg tggcgggcgc ggagatggcg
    15961 tggtcgcagg tcgcgctggg cgcgcactac cccaccgaca ccatcggcgg ctactgcacc
    16021 gcgctcgcgg tcaccccgct gacggccctg gcactggacc gcgtcggtgt cagcagtccg
    16081 gcgcgccgcc ggtgaacgaa ctgcacgtgt cctgaccgta gggctccgac cgccactgct
    16141 cgggcgtcag cgcccgcgag gtgtcgtgcg ccaggaaccg ccatggaccc gtgtaggtgt
    16201 tgccgtgcca gcggttgtcc tggccgaacg tgatcgcctc ggcgacgccg tgcccgtgat
    16261 agggcgacca gtcggggtac gtgccgtagt tcgccagcac ggccatccgt ccacacaggt
    16321 cgccgtcgca gtcgacgcgg gcggggtcga aacggaacgt gttgtcccgg atgtccaccc
    16381 gctgggtctt ccatcggcag tcgtcgtaca acggggccga ggcgatcccg ggccgcgtgc
    16441 acgtcgcacg ggactccacc agttccgtgc agtagccgct ggaggtgttg gccgggctgt
    16501 tgcagaaccg gtcggcgttc tcccacagcg tgatgcccga ccagttgtcc tcgaagacgt
    16561 tgccgtggat ctcgatccgg tcggtcctgg cgggcacccg cggctcgccg cccgcttcgg
    16621 acaggtacac cgtccccacc gggaagttgt cgccgcgctc ggcgaacctc gtgccctgca
    16681 ccagtgtgtt gcgacggaag gtgttctccc gcaggacgag gttgtagctg atctcgtaga
    16741 agacggcctc ggcctcgttg tcctcgaaga ggttgccctc caccaggaag tcgttgttgt
    16801 tcgtgtccgc ccacagcccg gcgccgtggt tgtggtggat ccagttgtcc ctgatgtcgg
    16861 cgccgtcgac ggcccagaat ttcatcgcac cgctgcagcc gcagccgggc accttggtct
    16921 cccagtcatc tgtgttgttg cccgagatct cgttggcctc gacgaccaga tccgtgatgg
    16981 tgtcgccctc ctggtaggcg ttgatgccgt actgaccgtt ctcccgcagg cagttgtgcc
    17041 ggatcacctg ccgagccccc gccatcagtg ccgcgccccg gttgtgctgg atggtgctgt
    17101 tccggatcac ccagccgtcg ccggagtcgt gattgaccac gccctggtcc tgtggtgcga
    17161 cgaacccctg gatggtgagg ccgtcgatga ccacgttctc cgcgcgctgg gtgaacgcga
    17221 accggttgag cccgcggccg tccagcaccg caccgggtgc gccgaggtag acgttgccgt
    17281 ccttcgggat cacctggccg aactcgtcgt cgccgagggt gtgcgttccg ggtgcgagcc
    17341 agaacgtggt tcccgccggg ccggccgcgg tcttggcgtg caggtcgttg tccacctccg
    17401 gccggacggt cacagcaccg gcgggcgggg tgctgtggtt cgccggctgg ttgtcacagg
    17461 gagccgtggg gccggggccg tccgccacgg ccgcaggagg cgagaccagt accgtctgca
    17521 ccacgcacag ggcgacgagg acggcagcac atcttctgac cattctggac aatctacgca
    17581 ggttcgctct gcgtggacgt cacccgaaag cgttgaccag gagggctatg cacaactcgg
    17641 ttgacggggg tcgccccccg ctccggcaat cttcttccac cgacatgggg cgctcgcggc
    17701 gaccgagtgc aggtgacacg cacggcaggc gcacctacgt gtgtgcataa cactccttcg
    17761 ccccaagtca ggagatgtta ggaaaagcgg cgaaagaccg gccgtaccgg cctgcctccg
    17821 gtccacgcca agggatcctc cgcgtccagc gccttgcggt acgtcgcgca ggcctgcgcg
    17881 accacctcca ccgtccggtc gatgtcctcc tcgctcagcg cgctgctgac cacgaaggac
    17941 ggaccgagga caccaccggc tacgagctgg cgcaggaaaa gggtgcggta ctcctgcgag
    18001 ggccgcagtt ctccgtccaa cgtggcgaag accaggttgg acgcccggcc gcggacaacg
    18061 acgtgctcgc cgacgcccat gccggcggcg acctccctga ccccggcggc cagccgttca
    18121 ccgagtgcgt gcaggcgcgc cgtgatgcct tcctccagat aagtccgcag gaccgccatg
    18181 gccgcggcca gcgagtgcgt ttccgcgcca tgggtcgtgg acagcaggaa aacccgttcc
    18241 ctcgaatccc gcagaccgcc ctgttccagc agtgcccgcc tgcccgccaa ggccgagacg
    18301 gcgaacccgt tgccgagcgc cttgccaaag gtggagaggt cgggcacgac cccgtacagt
    18361 ccctgcgcac ccgcctcgga ccagcggaac ccggtgatca tctcgtcgaa gatcagcaca
    18421 catccgaagc ggtcggccag cgatcgcaga cccgccaggt agccgggcgg aggctcctgc
    18481 tgccctgcgg cctccagcat caggcaggcc acctgaccat cgtgctcgcg cagcagcgcc
    18541 tcggtggccg ccaggtcgcc gtagggaaag ttgaccgtga gttccgtggt ccgcccggga
    18601 atccccgcgg gcatcggggt ggtcccgatg aaccagtcgt cggtggagaa gaacggctgg
    18661 tccccgcaga tcgccaccag cgggcggccg gtcgccgcgc gggcgagccg gacggcggcg
    18721 gtggtcacat ccgaaccgtt cttcgcgaac ttcaccatct ccgcggtcgg cacggtcgcc
    18781 aggaactgtt ccgccgcatc gagttcgagg atgctcgggc ggacgaagtt cgcgcccctt
    18841 ccgagttcac gacgtaccgc ttcgagcacc ctggggtggg cgtggcccag gctgaccgac
    18901 cgcagtcccg agccgtactc gatataggag ttgccatcga tgtcccatac gtgcgccccg
    18961 tgcccgtggg agatgaccgg cgccataccg tcggggtact ggtcatcccc tttcgcgtag
    19021 gtgtgcgcac cgccggggat cagctcgtgc aggcgggcgt tcgccgccgt cgaacggggc
    19081 agtgtcgaat cgggacggtc cgggaccgtc atggcgacac ctcggcggtg acgaattcgc
    19141 gccgcagccg gtccagcacg tccgccaggg agggcgcctg cctgtcccgc tccgacatca
    19201 tcgagacggg cagcggccac ggaatggcga gttctggatc ggcccaggag atcgtgacgt
    19261 cctcggcggg gtcgtggggt ctgtcgatcc ggtaggacac gtcggctgga tcggtcagtg
    19321 cctggaagcc gtgggcacag cctgcgggga catagagcgt gacctgggtc tgcccggaca
    19381 gctcgaagta ctccttgttg aggtaggtcg gcgagtccgg gcgcaggtcg acgacgacgt
    19441 cgaacacctc gcctgccgaa cagcgcacga gtttcgcctc ccccgcacct gatcgcaggt
    19501 gcattccgcg cagtaccccc agggccgagc gcgacagcga atcctgcacg aagccgtccg
    19561 ggtcgatccc caccgaccgc accacctccc ggtcgaaggt gcgggcgaag aagccgcgct
    19621 cgtcggcgtg cggcgcgggc tcgaagagat aggcgcccgc gatcgccggg acttcggtca
    19681 cgttcatcgt gcctcctcga cctggaaagt tccttcggtt ccgggaaaga gccgctcgca
    19741 caggtcccga aactgccgct cgagttcacg ggagtactcg gcgccgcgct ccagcattcc
    19801 gcgccgcaac tgctcgcgct gcttctccag cacatcgagc tgcttcatca gcagctcgac
    19861 gtcgaccgcc cgcgcggact gacagaactc gccgagaccc atgtcgatca tgatctggtc
    19921 gcttttcgcc gagtagctga tcgagatcgt cggctttccg agtttcacgg cgcagacgac
    19981 gttgtgatag cgagtgccga caacggagtc cactgtggtc atctgccgca tcaactccgg
    20041 gagcgaggtc accggctccg cgatcacccg ggcagagtcc gtttcggacc tggtgcgaca
    20101 cacgtcgccc aggatctccg ccacgaccac ctcgtccacc cggtcgccgg tgaacaaccg
    20161 gaccccgtgg cccgcgtcca gcagccggtg cacgaaccgc accatcgcgt cggcgtagtt
    20221 cgagcggatc tcccccgcgt gttcccggtc gtcgttgcca ccatggaagt ccatgacgcc
    20281 gacaccgatc gtccccggct cgggagacgt cggctccggt gcgggtagcg cgtacacgag
    20341 gtcggggtag accaggtccc gggaggtgtc cacacccatc tcgcgcatgg cttgccggga
    20401 cagtgcgtcg cggaacgagc ggtagtaggc cagccgcgcg gacgaggtgg acagccaccg
    20461 ggtgagtcgc tggccgatga cgttggcgcc gacattgacg agggcgaccc ttgttccgac
    20521 caacttgccc gacgcgcaca gcaggaacag agcgtaggga aaaccccatg gccgcaacgg
    20581 aagcgtcgtc tccagcacgc ccatccccgg cacgatgacg acgtcgaagc gccgggtcca
    20641 gcgcactgtc ctggccaggt cggcgatctt gccgacgacc ttgagcgccg acgccgcaat
    20701 attggaagtc ggccgcggcc gggcgtcgta ccagtgcagc tgggtggccg gaatcgcgaa
    20761 ccggcgggtc acctcctccg gctccgggca gaggcagtcg aaaaccgcgt ccgggtactg
    20821 cccgcgcagg tgactgagaa cggcgtcgag cgaaccgtcg ttacccatgt tccccgaacc
    20881 gaacaacccg aacagcccga ttctcggtcc ggtcacgagg tccgcctgtg cctgccgggg
    20941 acgaccgcgt ccaccgtccc cgacagggag tcgagctcgg cgggggcagc gggttcgggc
    21001 accgcgtccc ttcgccacgg cacggccctg ctcaccagcc actgcgcgag gtagcggtag
    21061 cactcgcgac gctgcgccga ggtcagcggc gctcgccgga tcgtgccgat gaatccgagc
    21121 acgtactcac cgagcagccg gacggtcggg tgccggaccg ggtccgcccg ccgggggtcg
    21181 aggttggcac agcggctgcg tttggtcgga ttcgcgcgct cggcccgggt ggggtgatcg
    21241 cggcggaaat acaggagttc ggggacctgg tggaaccggc cgtgcagcgc gatctcggcg
    21301 acgatcgtcc ggtcggcgtg gtggtagctg tcgtgcggtg cgacccggcg cagtgcgtcc
    21361 gcgcgaatga ccccgtagaa gtcgtcgccg cccggtgcga agagcaggct ccggaagcgc
    21421 tccggcgcgt gtggtgagtc agtggccatg ctgtagtcga acggctcggt caccgcaccg
    21481 gtgttgtcga tgatggcgtt ccaggagtgg gcgagcacca cctccggatc cgcgtcgagc
    21541 gtttcgacac agcggcgcaa cagctcccgg ccgtacaggt cgtcgtggga ggcccacttg
    21601 aagtactccc ccttcgcctc ggtgaagacg aagttgtggt tcggtgccgc cccgatgttc
    21661 ttcggcagcc ggatatagcg gattcgggag tcctcctcgg cataccggcg gcagatgctc
    21721 tccgtctcgt cggtcgaggc gttgtcggag atgatcagct cgaaatcgcg gaagctctga
    21781 ccgagcaggg cgtcgagcgc ctcggcgagg tactccgctc cgttgtagac ggggagcccg
    21841 atactcagtc gcgggacgtc ggtcatggtg tcctcatctc gtgaactctt cggtttcttc
    21901 gagcgattcg tcggacgtcg catggatgcc tgcctggtgc tcgcggtgcg cgacccgcag
    21961 ttgtccccac cagatggcgg cgccgcacca catggcgatc gcggaacccc agctcgcccc
    22021 gagcgcacct gcgatggtgg cgcccgcgag cccgccgccg aggtaccccg ccgacgcgat
    22081 cagctgggag cgcaggctgc gccgtgccgc accgagcgca cgcagacccg aagccgctcc
    22141 cgcgaccagt ccggcccccg tgaccgacag cgtgaccgga aggatcagcg cggaagcggg
    22201 ttcccagacc gagtccagca cgaactcgcc cgcgatgtcc ggcacgagca gcagcgcgca
    22261 gccccagacc aacgccgccg cggcctggct gccacccagc acgaggcaga acttcgggag
    22321 ccggtgcggt gagcgccgca ggacccgcgc tgcctcggga accgcgacca ggctgaggcc
    22381 catcagcacg gcgaggaacg ggccgagcaa cagttcggct ccccggatcg cgccgacctc
    22441 gctgaggccg gcgatcgcgc cgaggccgta catccgcaac tgggaggcgc cactgttgct
    22501 gacgttctcc acgagatagc gcggaccgag gtcccgctgc tgacgcagcc acactgccgc
    22561 ctgcacgccg gccggaacga caccggactg caggtacccg aacccggccg cgacgccgcc
    22621 ggaaacgccc caggccagca cgaaccagaa gacgcttccc tgctgggcgg cgagcaccag
    22681 tgcgggaatc agcgcagcgc cccagacgac gtcgttgacg aacgccttgc gcccctgtcc
    22741 cgctgcgaag aaggcaaaac gccagctgtc ctgcaacagc agcatgggga acacgagacc
    22801 gagcgcgacg aacgcggcac cgagcccacc gccgatggcc agtcctgcga gcacactgac
    22861 cactccggac acgaggccga tgagcagggc cgtgccggag gacctggcca ccgccgcgcg
    22921 ccaggctgcg ggcgagaccc cgctgaaccg gacgaccagt gggtcggtgg tgagcccccg
    22981 ggaaatgttg agcaccaggc cgtaggtcac ccaggcaagg gtgaagacac cgaactcggt
    23041 caccccgagc gtgcgagcca catagatgcc gacggcgaag ttggtcatgc tggacacggc
    23101 ctggtcggcc agtccccagc tgatccgccc cgccaccgca cgcatcgccg tcgaagaccc
    23161 ggccgcacga tgtctgccgg cctgccttgg cggcggaccg ggcgcctcgg gtcccgcgtg
    23221 acgaccgtgg ctcacgtccc gtccgcctcc ttgagcagcc cggcatcccg taatgcgtcg
    23281 gcggcggcga cgaccgtgtc gaacggcagt tcggcacggt cggcgacgtc gagcaggctg
    23341 tgctcgccgt cggagaggtt gagcacccag agcatcgcca gctgcgcctg cttcgcgtcg
    23401 ctgcgcccgc cgagggagtc gtacagtcca cgcctgccca gctgcggttc gccgtagggg
    23461 ctcaggttca cgtacgtccg gttgcggtcc aggacggcga acgcctcgcg gcaggtcgcc
    23521 agcgtgtccg acatcgactc ggccaagacg aagtccgggt tgtcggcgga ggtgtggtac
    23581 tccgggtacc ccgcatgcgg ggtacgggtc agcgatccga cgccgaggtt gaaccccggt
    23641 gagcagaact ggcgttcgtc atagccgtac ggcgagaacc ggacgatctc gtgtggacga
    23701 ccgctggcgc gcagcaggtg ccgcagcacc cggtctatct cggcgtcccc gcgcctgctc
    23761 tgcttgtagg tcaaggaacc gcgatcaccg gcgcaggcca gcaccagccc gtgccggatc
    23821 cggtccaccc gctcgaagtt gcgagccagc caggtgatgg agccgatggt tccaggaacg
    23881 aacaggaacc ggtaggtgtg gtgcggtgcg gccgcggcca gttcacccgc gagcgccgtc
    23941 gccaccgcga tgccggccag gttgtcgttg gccagcgcgg ggtggcacac gtggcaggac
    24001 acgatgacct cgtcggcgac ctgcccgggt acgacgtact cgccataggt caggtgccca
    24061 tcgccgagcg tggagtcgat gtgcacctcg tagtccccat ccggcatcgc gtccagtgtg
    24121 ttctgcgcga ggcagaatcc ccagtccggc gcgtagtagc tggttcggta cggaatccac
    24181 gagggatgct cgggcagggt gtgcaggtgc gaccgcagct gttgcagcgt catggtcgcc
    24241 gataccggca cgctgtaact gaccacgtgc aggctcgagt cggcgaagtc caccacccgg
    24301 ttgcccgcgc tgtcggcgat gtaggcgtcg cggatgttcc attcctgcgg cacggtccag
    24361 tcgaggaccg gtgtgccggt cggcacctcg tgcacccgca gcgggatgtg ctcggacagg
    24421 atctccagtg tccggcgcac cccgtcgccg gtgatgctcc ggcagagcgg atacagccgc
    24481 tccaccagtt cgtgcatccg cgcgccgtcc atcagcggtg ccgcagggtc tcgtcgacct
    24541 cgcccgcggc cgtccggtcc ttcagccagg ccagccgggt gaaccgctga tcgaagccgt
    24601 ccttggtgag gccgaaccgc cggtacgcct cggtcagctc caccgcaccg tccttgaccg
    24661 accactcgca gtcgaacccg ggaactgccg cgcggaagcg ggagaagtcc actctgtacg
    24721 agcgcgggtc cgctccggcc tcaccggtga tcagcagccg ggaaccgggt acggcctcca
    24781 ccacctggtc ggcgatctgc gcgaccgtca cgttgttgcg ttcggtgccg atgttgaacg
    24841 cccggtcgtg cacggtctcc ttcggagccg tcagcgcggc ggcgaaggcc cgcgcgatat
    24901 cgcccgcgtg caccagaggc cgccacgggg tgccgtcgga gagcacgcgc acctcaccgg
    24961 cgaggcaggc gtgcccgacc aggttgttca gcacgatgtc ggcccgcagg cggggtgaga
    25021 acccgaaggc ggtggcgttg cgcaggaaga ccggcgagaa accgtcgtcg gccagttcgt
    25081 gcagatcgtc ctcgacccgc accttcgact cggcgtacgg ggtgaccggt cgcagtggcg
    25141 cgtcctcccc caccaggccg tcaccgccgg aggcgccgta caccgagcag gtcgaggcgt
    25201 acaggaacct gcgcacgccc gcgtccttgg cgagcctggc cagccggacc gaggcgctgt
    25261 ggttgatgtc gtaggtgagt tcgggagcca gcg
//
