LOCUS       NZ_FOKG01000002        21590 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Amycolatopsis marina strain CGMCC 4.3568, whole genome shotgun
            sequence.
ACCESSION   NZ_FOKG01000002
VERSION     NZ_FOKG01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis marina
  ORGANISM  Amycolatopsis marina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900111885.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:41:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,708
            CDSs (total)                      :: 6,643
            Genes (coding)                    :: 6,572
            CDSs (with protein)               :: 6,572
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2, 5 (16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 22 of 71
            Pseudo Genes (incomplete)         :: 62 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 15 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:06:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 332069
            Orig. end                         :: 353659
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOKG01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21590
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21590
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21590
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11590](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11590
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            380..736
                     /locus_tag="BM199_RS05730"
                     /old_locus_tag="SAMN05216266_102318"
     CDS             380..736
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS05730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_102318"
                     /product="hypothetical protein"
                     /protein_id="WP_091670565.1"
                     /transl_table=11
                     /translation="MYRIRVRWVGEDPRAALSAESDLSKSQVRTIEQQLARMDARSRHG
                     AWTHDVLTLVAAHPERRAADLADMLGRDKDALKLDIRKLKNLGLTHSLDVGYRISPRGS
                     AYLRARAEDLDTKG"
     misc_feature    923..936
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.43"
                     /tool="antismash"
     gene            949..1149
                     /locus_tag="BM199_RS05735"
                     /old_locus_tag="SAMN05216266_102319"
     CDS             949..1149
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS05735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_102319"
                     /product="hypothetical protein"
                     /protein_id="WP_091670568.1"
                     /transl_table=11
                     /translation="METRNSQMARQHSVANSGPGAQSSVLRAGSMEDPHVGLNIPGGPV
                     VPGPRITEDDEFEPTIVRGRE"
     gene            complement(1162..1710)
                     /locus_tag="BM199_RS05740"
                     /old_locus_tag="SAMN05216266_102320"
     CDS             complement(1162..1710)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS05740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_102320"
                     /product="hypothetical protein"
                     /protein_id="WP_091670571.1"
                     /transl_table=11
                     /translation="MTVAELVGRARTVALRRRPDDTMPMPAVSAGDVGARHRRPAASGS
                     PVGEGRSRSRLAVGGGAVAILSMFLVAGGLVLGQGGGEQPPGDISDGAVAPARVGAPTV
                     VTIEGVAHPGENPPVSTPAASQQAEAPEVAERDAAERRSDPDASAPAQDSGGRAGEDLE
                     RRFEEWESRINELPGVPDW"
     misc_feature    2257..2271
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            2446..2844
                     /locus_tag="BM199_RS05745"
                     /old_locus_tag="SAMN05216266_102321"
     CDS             2446..2844
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS05745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_102321"
                     /product="hypothetical protein"
                     /protein_id="WP_091670574.1"
                     /transl_table=11
                     /translation="MRDLVSQARPDVLAELGTDGLLRLRSTRRPHLGHLQVEPYIEGTR
                     ILLRPVAARISRLRVLLPARTRPIPVDLPDLPGGLRLTGIGTAPAELTLYGVTDYWRDR
                     LATIPLSTLLGAVTSAVSTLTVPWLGES"
     gene            complement(2841..3656)
                     /locus_tag="BM199_RS05750"
                     /old_locus_tag="SAMN05216266_102322"
     CDS             complement(2841..3656)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF016550.4"
                     /locus_tag="BM199_RS05750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102322"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_091670577.1"
                     /transl_table=11
                     /translation="MRERAPVAIDTSVPSIARIYDYFLDGKDNFACDRELAAELLRVAP
                     EARAMARDNRAFLGRVVRYLAGCGITQFLDIGTGLPTQNNVHEVAQEIAPDTKVAYVDN
                     DPVVLVHARALLADNPHTIVVEADVRDPRALLADPALRELIDFDQPVAVLLVGILYFFP
                     EEDRPFDIVAAFRDAVAPGSYLALSHVVADEGPDELGRAQELYRTFLKRSGDARRTRAQ
                     VLSFFDGLEFAEPGLVPARHWRPDPGTTADTGDGAGWILGGVGRKKASG"
     gene            complement(3662..4666)
                     /locus_tag="BM199_RS05755"
                     /old_locus_tag="SAMN05216266_102323"
     CDS             complement(3662..4666)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154321.1"
                     /locus_tag="BM199_RS05755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102323"
                     /product="EamA family transporter"
                     /protein_id="WP_245788174.1"
                     /transl_table=11
                     /translation="MTAVRLDSPLTPTPAPSWRSAARRTVRRPGDGSQLGSVALVLGGA
                     VSLQFGAAIAALLFPRAGAMGVVSLRLTLAAVVLLLICRPKVRGHARADWALVAAFGVA
                     LGGMNALFYQAIERIPLGAAVTLEVLGPLTLSVLAARRMASLVWAGLALAGVILLGRGG
                     FDSLNVEGVLFALAAGVLWAAYILLSARTGRRFPKADGLALALAIGAVLSLPFGVATAG
                     AALVDPVTLALGAAVALLSSMLPYTLELLALRRIAAATFAVLMSLEPAIAAFAGFLVLS
                     QALSLLEGLGMALVIVASMGAVRLSTSARSRDQRRPDTEDQGHRPVPPNGAVP"
     gene            4736..5620
                     /locus_tag="BM199_RS05760"
                     /old_locus_tag="SAMN05216266_102324"
     CDS             4736..5620
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010312059.1"
                     /locus_tag="BM199_RS05760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102324"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_091670579.1"
                     /transl_table=11
                     /translation="MTIELRHFRCFLAIAEEGNVTRAAGRLHLTQPAVSRTLRQLEQQL
                     GLRLVDRSTHHLRLTDDGLAFRDKAATVVAAADDALDTRRLRSWPLRMGHAWAAAGAFT
                     STLLRRWEHAHPDTPLELLRIDDRTAGLTTGQVDVALLRGVVDAPGLVVEPLLTEPRVA
                     AMPADSPLAERAELSLADFTDQTVAVNTISGVTTPHLWPPEIRPARTMTVANTDDWLAA
                     IAANRAVGITTSATSDLHRYPGVVYRPMVDAPEIPVVLAWRRMPGHPAIPTLVALFRDV
                     VGEGRTDRKPDKS"
     misc_feature    complement(4743..4756)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    5802..5816
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.18"
                     /tool="antismash"
     gene            5807..6865
                     /locus_tag="BM199_RS05765"
                     /old_locus_tag="SAMN05216266_102325"
     CDS             5807..6865
                     /GO_function="GO:0004181 - metallocarboxypeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667082.1"
                     /locus_tag="BM199_RS05765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102325"
                     /product="M14 family zinc carboxypeptidase"
                     /protein_id="WP_091670582.1"
                     /transl_table=11
                     /translation="MRKSRLIVVLSALALAVSSFGLAHPATAAPETSGTTSAPDTMRGG
                     RIDPHPSTAELTRELQRLQWRSRGAVDVSEIGRSNQNRPVWSARVGNGPLRIMYVTQQH
                     GNEPLGTPAALKFLETTGVGQSAWQRWLRSRVTVDIIVRANPDGSELNWRYNYDPEADP
                     EYGEAGKGYDINRYHSPILAPEDNPATEAGLIQRHYAEFEPDIMVDYHMQGRYADADGE
                     EITASVMWPTRPDVRADMVRLAKQVSVVAQRAMDLAGANVSQYPGGNYEGIARNAYGLR
                     GSGSVLIEFSAMGPEHDRQQIASAWVSMIGIAQSGASGSLQRVDPTWAERIPPRGEPIR
                     TQAASALASHGD"
     gene            6941..7330
                     /locus_tag="BM199_RS05770"
                     /old_locus_tag="SAMN05216266_102326"
     CDS             6941..7330
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671020.1"
                     /locus_tag="BM199_RS05770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102326"
                     /product="hypothetical protein"
                     /protein_id="WP_091670585.1"
                     /transl_table=11
                     /translation="MAELDGFPLTNLLIYAVVAVAPTLVFWIALSAMAATRRRRRPAGE
                     PVHRPIQELAADLRRVHRLLLDFGPGTPAARRKGTRQAYDALLIQACAAVEVEHELAVL
                     PEGVDREVERLRVEEALRGAGLAIP"
     gene            complement(7345..7809)
                     /gene="soxR"
                     /locus_tag="BM199_RS05775"
                     /old_locus_tag="SAMN05216266_102327"
     CDS             complement(7345..7809)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="soxR"
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016700153.1"
                     /locus_tag="BM199_RS05775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102327"
                     /product="redox-sensitive transcriptional activator SoxR"
                     /protein_id="WP_091670588.1"
                     /transl_table=11
                     /translation="MEEPAWTKAELTVGQLAARSGVAVSALHFYERQQLIESRRTSGNQ
                     RRYRRDTLRRLALIRIAQRAGIPLAEVRGALAELPDGRTPNRKDWQRLSKRWRSEVDAR
                     IRHLQQIRDSFTDCVGCGCLSLDRCGLANPRDELGRQGPGPRRLLGPGEV"
     gene            7988..8854
                     /locus_tag="BM199_RS05780"
                     /old_locus_tag="SAMN05216266_102328"
     CDS             7988..8854
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101229.1"
                     /locus_tag="BM199_RS05780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102328"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_091670964.1"
                     /transl_table=11
                     /translation="MPQRNSADAVLVIGATGNVGRQVVHQLLEAGATVRAMARNPNTAA
                     LPGDAEVVAGDLTDPATVAAAAKGTRAAFLAWPFFTGEAAPAVLEALRPDVRHVVYLSS
                     AGADEADGPVGFHYELEQQITHSGLEWTFLRPSGFATNTLGWADQIRQADVVRWPYGKA
                     SRSLIHESDIAAVATAALTGQGHAGKVYDLSGPEQLTQIEQVDAIGAAIGRKLHYEDVS
                     RERARRELLAEWPDEFAEGALDAWAELVTAPEPITTGVRDVIGRPPRTFREWAVDHAED
                     FRSERVG"
     gene            8899..9732
                     /locus_tag="BM199_RS05785"
                     /old_locus_tag="SAMN05216266_102329"
     CDS             8899..9732
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (25-261). E-value:
                     1.4e-25. Score: 82.2. Matches aSDomain:
                     nrpspksdomains_BM199_RS05785_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020632264.1"
                     /locus_tag="BM199_RS05785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102329"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_091670591.1"
                     /sec_met_domain="PF00561 (E-value: 2e-20, bitscore: 68.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.5e-18, bitscore:
                     60.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEQLSIPTAAGHFDAIASGPTEGRPVLLLHGFPEAGIAWEHQVA
                     ALGGHGYRAVAPDQRGYSPAVRPERTGDYDMSELVADVLAIADALEWNRVDLAGHDCGA
                     GVAWTVAEQHPERVRSLTAVSMPHPAALADAQRTDEDQALRSGYLTDWRQTRTTERRML
                     DNDAEALRRMFEWRVPPSRVEEYVQRLTEPGALTAALNWYRANRPGARIGPVSVPTLYV
                     WSTDDVAFGSTAALETGNWVTGPYHFHMLEDVSHWVPEEAAGAMSSLLLEQLNTH"
     aSDomain        8974..9681
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM199_RS05785_Abhydrolase_1.1"
                     /evalue="1.40E-25"
                     /label="BM199_RS05785_Abhydrolase_1.1"
                     /locus_tag="BM199_RS05785"
                     /protein_end="261"
                     /protein_start="25"
                     /score="82.2"
                     /tool="antismash"
                     /translation="PVLLLHGFPEAGIAWEHQVAALGGHGYRAVAPDQRGYSPAVRPER
                     TGDYDMSELVADVLAIADALEWNRVDLAGHDCGAGVAWTVAEQHPERVRSLTAVSMPHP
                     AALADAQRTDEDQALRSGYLTDWRQTRTTERRMLDNDAEALRRMFEWRVPPSRVEEYVQ
                     RLTEPGALTAALNWYRANRPGARIGPVSVPTLYVWSTDDVAFGSTAALETGNWVTGPYH
                     FHMLEDVSHWVPEE"
     misc_feature    9703..9705
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..11590
                     /locus_tag="BM199_RS05790"
                     /old_locus_tag="SAMN05216266_102330"
     CDS             10001..11590
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012796325.1"
                     /locus_tag="BM199_RS05790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102330"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_091670967.1"
                     /sec_met_domain="T2TS (E-value: 1.6e-92, bitscore: 305.4,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDPSGDFSPSIYETARLVALTPSLRGHRRRLRFLLDQQRPDGS
                     WGGPEGYSLIPTLSAIDALLAVLQHENSNRDRGTGDVAGALGRGLHWLRGHLEPGAGTA
                     LPDTVAVEMLAPGLVSAINLRLDQLAALAPVGVEVGWGAARLRPPPESNEALLDRVRVA
                     VLDGRSLPVKLLHSLEVLGADTRDATVPVAESGGVGCSPAATAAWLGDDRVRQGHPSVR
                     YLEEVQEPHSGAVPVAAPLGLFERAWILGTLGSTGITKLAPESLLDSLRNGLGEAGAAG
                     GDGLPPDADDTAAALHALALHGEARAADPLWTYWTEEGGGHVSCFPGERTPSTSTNAHA
                     LQAFATSAEPADVDVQRRGVAIRSIVDWLREQQTREGYWTDKWHASPYYATVCCTVALA
                     EHGGTAAAPSVAAAVRWVLETQHPDGSWGRWSGTYEETAYAVQILLRTGLPVDEATALA
                     AARGCRFLIANADLTEHPALWHDKDLYTPTRIVRTEGLAALHVARSDPRTAALLHEDGD
                     GSAREPAGRAVC"
     gene            11587..12831
                     /locus_tag="BM199_RS05795"
                     /old_locus_tag="SAMN05216266_102331"
     CDS             11587..12831
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006237535.1"
                     /locus_tag="BM199_RS05795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102331"
                     /product="cytochrome P450"
                     /protein_id="WP_091670970.1"
                     /sec_met_domain="p450 (E-value: 1.1e-54, bitscore: 180.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGVELRLALRTLPFLDARSDLPEGMLDLRQGPHAKLLVWHPDAI
                     DRIFRSDRRLLHPGSNSLMPLFGAGSLLWADGERHAAYRRALGPPLRGKRLTVYEGLIS
                     RITHEALDELSAGSLVALPAWSRRIALRVVAAIVLGAANDTVLVPFTRWIDRALGSRRR
                     TLAYRYLRGGLPRSSAELDRSLIRQAKVHRGGLPPTLAAVMLSGEGPLGKVDDEELRDQ
                     LVSLLFAGHETTASATAWTLYHLARDRQLTAAVRAEIEAAGDGGADAGRVPLLQAVIQE
                     ALRLAPPVTVAENRTLTEDTELLGRTLPAGTTLTPSIYLAHRRRDSFADPRRFDPARFL
                     DTKASPQRYLPFGGGSRHCLGSGLAQLEIRMITAAVLGRLDWECVNPRAAVPELRGHAM
                     APSAKLRMRVTGCRA"
     gene            12819..13748
                     /locus_tag="BM199_RS05800"
                     /old_locus_tag="SAMN05216266_102332"
     CDS             12819..13748
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013226.4"
                     /locus_tag="BM199_RS05800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102332"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_091670594.1"
                     /transl_table=11
                     /translation="MPGLTRTPTRGLWGDLVVLHRLEHPLPVMYVCYASWGACYATGDV
                     RGLLHPPVLLAILANLLLLIGGLALNNIVDVPTDRQHKDKAYLSSAALRVGEQKALWLA
                     LTETAAGLILSIVVSVVTGRWIVAAMALGIALLHVLYNVRPVRLKGRGLAGSIAFGLSV
                     VALPSLLSHGAVSQTLPGWVLAVLAGASVLAVGRTVWWSAPDRAADLISGVATPAARYG
                     VPRTLVLSCLILLSGLVLLGGGLWAHFGFVTVVAGALAHAVFTGTAVFQLLRATRGIAP
                     TASAMRRHALLLVLAGELSIALVPLLAS"
     gene            complement(13752..14600)
                     /locus_tag="BM199_RS05805"
                     /old_locus_tag="SAMN05216266_102333"
     CDS             complement(13752..14600)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012796322.1"
                     /locus_tag="BM199_RS05805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102333"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_245788175.1"
                     /transl_table=11
                     /translation="MALPGGPAQPGSTRSDAAGPDAGEVDVAHPSIARIRDSWLGGTHH
                     DDADRGFADQIVVCAPHLPYLVRAQNAFVRRLVRYLTDRGVRQFLDLGSGVPDINAAHR
                     VAHEVDPEAKIVYVDLDPTIAQDSADLLAGTGNAAFVRADVRRPDEVLGAPEVTDLIDF
                     GEPVAVLMIEFLLHLQDSENPAGLVAAYMDAVPSGSYLGISHFSQDDQLHEGLTLFSRM
                     FGAPPAVKLRDPGELVRFFDGVEIVEPGIVPVPLWHPEPGDEQVRNPELVRVHAGLGRK
                     V"
     misc_feature    14679..14693
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.42"
                     /tool="antismash"
     misc_feature    complement(14717..14732)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.34"
                     /tool="antismash"
     gene            14863..16368
                     /locus_tag="BM199_RS05810"
                     /old_locus_tag="SAMN05216266_102334"
     CDS             14863..16368
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007023883.1"
                     /locus_tag="BM199_RS05810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102334"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_091670596.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-43, bitscore:
                     143.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAASVNPDRSEWDVIVLGGAAAGENAAQYATQFSGLDAVLVENAL
                     VGGECSYWACMPSKALLRPVEVLDTARHLPGLASVVEGLRLDVDEVLARRDKIVSNLDD
                     AGQVRWALGAGIDVVRGYGRLTGARTIEVTGADGTVRTLIARHAVVLDTGSAASIPPVP
                     GLREALPWTSRDVTNLHEIPRRVVILGGGVVACEAATWLYGLGVDELTLVNRGPQLLAG
                     NEPFAGELVADRLRKAGVTVHAERTMSEVRREDVRDSGVGRIHGGEVKVTLDDGTMLTA
                     DEIVVAAGRKPNSDDIGLDKLGVSPGGYVDVDDQQAVRGVGGEWLYAIGDLCGRALVTH
                     MGKYQARIVGEVIAARAKGEQLELGEYGRHTAAAGHRTVPQVTFTDPEVGSAGLTEQQA
                     REQDIDVETVEYDLAALAGTFLLREDYSGRAKLVLDRAKDTIVGATFVGTGIADLVHSA
                     TVAIVGKVPVSALWHAVPSYPTPSEVWLRLLETLNADRRGGSA"
     gene            16373..17329
                     /locus_tag="BM199_RS05815"
                     /old_locus_tag="SAMN05216266_102335"
     CDS             16373..17329
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /GO_process="GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1279: pseudouridine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152820.1"
                     /locus_tag="BM199_RS05815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102335"
                     /product="pseudouridine synthase"
                     /protein_id="WP_091670975.1"
                     /transl_table=11
                     /translation="MRRRQPAPLPQRDGLDPARMRMPTEGAWATIRDHLVDRIPKLAPT
                     RIDEMFSERRFFGEHGPLDADAPFVPGSVIWFHRDLPDEVPVPFEIDVVHRDENLLVVH
                     KPHFLATIPRGQHIVETALVRLRRDLDLPLLSPAHRLDRVTAGLVMWVIRPEYRGAYQN
                     LFRDRLVRKEYEAVAPFDPALDLPRTVRSRIVKERGVITAQEVPGTPNSETTVELIEHS
                     GGLGRYRLLPATGRTHQLRLHMSNLGVPILGDDFYPVLHETPLDDFRRPLQLLARTLEF
                     TDPLTGEPRRFESPGELQAWTDLAGWSGTQDGQHSIE"
     gene            17377..18228
                     /locus_tag="BM199_RS05820"
                     /old_locus_tag="SAMN05216266_102336"
     CDS             17377..18228
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663010.1"
                     /locus_tag="BM199_RS05820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102336"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_091670599.1"
                     /transl_table=11
                     /translation="MPEPKDPEFVPEGVDLERPNPARIYDWFLGGSANWAIDRAFGEKV
                     LETFPQARTIARTGRDFLGRGVHYLARQGVTQFLDLGSGVPTVGNVHEIAESVNPDSRC
                     VYVDNEAVAVAHSRVLLEKHGESSRHAVLHGDLRQPDDIWKRALATGVLDPEKPIGLIV
                     VGVLYFLGPEDDPHGVIARYRDLLPSGSYLLSSHLTEDEVPDEGGTEREEVRQQYQRSS
                     SQLYMRNREEFTAFFDGFELVEPGVVWLPEWRLDERESKASRKYANTPQESSSIGALGR
                     KP"
     gene            complement(18376..19038)
                     /locus_tag="BM199_RS05825"
                     /old_locus_tag="SAMN05216266_102337"
     CDS             complement(18376..19038)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009950873.1"
                     /locus_tag="BM199_RS05825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102337"
                     /product="response regulator transcription factor"
                     /protein_id="WP_091670602.1"
                     /transl_table=11
                     /translation="MNRILVVEDEERIASFVRKGLSANGFATTVVGDGTSAVELARGGS
                     FDLMILDIGLPDQDGFSVLRSMREARVSIPVIILTARDSVRDTVAGLEGGADDYMTKPF
                     RFEELLARVRLRLRRADNTPEATLLRVTDLSLDLRTRRAQVGETTVELTAREFTLLELF
                     LRHPGQVLSREQILSHVWGYDFDPGSNIVDVYVRALRRKLGADRISTVRGMGYAVGR"
     gene            complement(19035..20570)
                     /locus_tag="BM199_RS05830"
                     /old_locus_tag="SAMN05216266_102338"
     CDS             complement(19035..20570)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803647.1"
                     /locus_tag="BM199_RS05830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102338"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_245788176.1"
                     /transl_table=11
                     /translation="MTTTRTTTATTTGMTTKTTTEPRTLPVVGSAPARRTRRRGLPARA
                     RIMGWLILLMAVVLLSVAVVTRNLLLHQAESSAVAALEQEAREFSGVAASGVDRATGQP
                     FGSVRELLRNHLQRQYPDDDEVIVGVVRNGAAREVLRQEREAPMRLYDRPELLDPILAA
                     TSTSGSIGTAAGEMRWVKVTATGPAGQGAEGIFVVGYFIDRDRAEVHRTIRTLGLVSLL
                     GLILTAGASWLVAGRILAPVRLARAAAAHITEHDFTRRVPVEGNDEFAALAEQFNAMLE
                     RLEKAFATQREFLDDAGHELRTPITIIRGHLELLDPVNDDPDERLAAVRVCTDELDRMS
                     RIVDDLLLLAKAERPDFVQLKPVEVAELTSDIYAKIRALGDRRWRLESIGEGRVMLDEQ
                     RVTQAVVQLAHNAVQHTETDGEILLGSSVYRGWASFWIADRGPGVSQEDAAVIFDRFAR
                     GSNAKRTSGGAGLGLAIVQAIARAHHGGVRLVPTSGGGATFGLELPARGEGVQ"
     gene            complement(20509..20823)
                     /locus_tag="BM199_RS05835"
                     /old_locus_tag="SAMN05216266_102339"
     CDS             complement(20509..20823)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009950869.1"
                     /locus_tag="BM199_RS05835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_102339"
                     /product="hypothetical protein"
                     /protein_id="WP_091670608.1"
                     /transl_table=11
                     /translation="MKLAARLTVPLAVIAVPLTAALASYVLTEDVPPPDVPAQVRIGQV
                     EGPDGGDSRLGPSGTQQSEPAPGTSTMQVVPPPPPISDDDDDDQDDDSDDDGDDDEDDD
                     "
     gene            complement(20914..21258)
                     /locus_tag="BM199_RS33195"
                     /old_locus_tag="SAMN05216266_102340"
     CDS             complement(20914..21258)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS33195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_102340"
                     /product="hypothetical protein"
                     /protein_id="WP_143101775.1"
                     /transl_table=11
                     /translation="MKITRPWVVVGATLAVAGFGTAVAAASEPAALNEPRPAPTVHLAD
                     YEPMTAADNVGNDDSPESADSPGESPVDSAASAAELPDGPDSADSPDSPDSPDIPADSP
                     DSPDSPDSPA"
ORIGIN
        1 cgatcccgga ggcgctcgcg ggctggttcg ccgacgcggc aggcggatgg ccgcgccagg
       61 aaccacacgg tcccgccatc gagaagacgt ttgacggcct cggcgaactg gcggacagcc
      121 acctctccga gccgttcgac ggcaccgccc cggtgaaccc ggtcctccgc ctgacgccac
      181 ccgaataagt cgcgcggagt ttgcagtttc ggggcccgag tttgcagttt gtgtgcgtga
      241 gttggcagtt tgtgcgcgcg tgtgcgttcc agggacacgt ggtggggttt cgggcacgcc
      301 ttcggcgcgc cctgcgcaat tgtcgctcca cgcatcaccc tttcgaggtg gccggtagcg
      361 acaattcaac gatcatccgg tgtaccggat ccgggtccgg tgggtgggcg aggacccgcg
      421 cgccgcgctc agcgcggagt cagacctgtc gaagtcgcag gtcaggacca tcgaacagca
      481 gttggcgcgg atggacgccc ggagccgaca cggcgcgtgg acccatgacg tgctcacact
      541 cgtcgcagct catcccgaac gtcgagcagc cgatctggcc gacatgctgg gccgggacaa
      601 ggacgcgctg aagctcgaca tccgcaagct caagaacctg ggcctcaccc acagtctcga
      661 cgtcggctac cgcatctccc cgcgcggttc cgcctaccta cgtgctcggg ccgaggatct
      721 ggacacgaag ggctgattct cgctcgctcg ggcctgtgga cgacacaaaa tccgttgagc
      781 ggaacggggt cggcagagaa tactcggggt aacgccagtt cgctgccgat cgatgttttc
      841 ggtacagggg cacgggtagc caaggggcgt ccgcctgcat attcgccggc acggatggtg
      901 ccggccgcag gcgcgatcgt gcatgacgct gagtgaaggg agttggctgt ggagaccagg
      961 aacagccaga tggcgaggca acactcggtt gcgaactcgg gcccaggtgc gcagtcgtcg
     1021 gtacttcgcg ccggctccat ggaggatccg cacgtcgggc tgaacattcc cggcggcccg
     1081 gtggttcccg gtccgcgaat caccgaggac gacgagttcg aaccgaccat cgtccgcggg
     1141 cgcgagtagc gccaccgacc tctaccaatc cgggacaccc ggcagttcgt tgatccggct
     1201 ttcccactct tcgaacctgc gctcgaggtc ctcgcccgct cgtccgccgg agtcctgagc
     1261 gggagccgaa gcgtccggat cggatctgcg ctcggctgcg tcgcgttccg ccacttccgg
     1321 cgcttccgct tgctgggacg cggcgggggt gctcaccgga ggattctctc cgggatgcgc
     1381 gaccccttcg atggtcacga ccgtgggcgc acccacccgt gcgggggcca ctgcgccatc
     1441 ggagatgtcg cccggcggct gctctccccc gccttggccg aggaccaggc cgcctgccac
     1501 caggaacatc gacaaaatcg ccacggctcc accgcccacc gccaacctgg aacgcgacct
     1561 gccctcgccg accgggctac cggaggcagc tgggcgccga tgccgggcac cgacgtcacc
     1621 ggcggagacg gcaggcatcg gcatcgtgtc atccggcctg cgtcgcaggg ctaccgtccg
     1681 tgcacgaccg acgagttccg cgacggtcac cgtctcctcc ggggaagact cactcctccg
     1741 cggagtcgta cgggccatcg gatacctcca tcgggcgagg aacgaacgcc cgatgctatg
     1801 gagccgcaac gcgagtagta aagcattgcc cttcgtgtgg cccaaccctc cgctactcct
     1861 tgtcacccgg gtgacaagaa cagacacagg ccgtacttct gactactcag ggtgtcaccc
     1921 ggccagtgac gtcagcctct cgaaagccgc tgggcccgac caacacccgc ccactgggcc
     1981 acactgaacg gatgaacgag ccagcacgcc gatcgtccgg gcaggcggca tgagcattcc
     2041 cggagcgttc ggttcgtggt tgccatggcg ggaactggac gggctgctca cggcgggccg
     2101 gaccctgctt ccctcggtgc cgaccagccc ctccggtgtc ctgcaagcgg cagtccgcac
     2161 cgtgagcgat cggctcgtgg gcaaacgtct caccgtccgc gccgccgaca ccgatctgcg
     2221 catgacgctg gccgagttcg actgccgggt ctcgtcggtg gggatcggcc aggcggaggt
     2281 cggggatctt cggctggtcg tggcggacgt cgagagcacc gacagcggac acatgccggt
     2341 gcggcgagcc gagatcgtgt gccgggacct ccgggtccgg tccctgcctg ccccgacact
     2401 cggaacggaa tccatccaac tggccatcac ggttgacggg acgtcgtgcg cgacctcgtc
     2461 agccaggccc ggccggacgt tctcgccgaa ctcgggacgg acggtctcct gcggctgcgc
     2521 tccactcgcc ggccgcactt gggccacctg caggtcgagc cgtacatcga agggacgcgg
     2581 atcctgttgc ggccggtggc ggcgcggatc tcccggctca gggtgctgct acccgcgcgc
     2641 acccggccca tcccggtcga cctgccggac ctgcccggcg gactgcgcct caccgggatc
     2701 gggaccgcac cggccgaact gactctgtac ggcgtcaccg actactggcg cgaccggctc
     2761 gccaccatcc cgctcagcac cctgctcggc gcggtcacct cggccgtctc caccctcacc
     2821 gtgccctggc tcggcgagtc ctagccgctc gccttcttcc ggccgacgcc gccgaggatc
     2881 cagcccgcgc catcgccggt gtccgccgtg gttccgggat cgggtcgcca atgcctggcc
     2941 ggcaccagac cgggctcggc gaactcgagc ccgtcgaaga aggacagtac ctgcgcgcgg
     3001 gttcgcctgg catcacccga gcgcttgagg aacgtgcggt acagctcctg cgcccgaccg
     3061 agctcgtccg gcccttcgtc ggcgacgaca tgcgacaggg cgaggtagct gcccggcgcg
     3121 accgcgtcgc ggaacgcggc gacgatgtcg aacgggcgat cctcctcggg gaagaagtac
     3181 agaatcccga ccagcagcac cgccaccggc tggtcgaaat cgatgagctc gcgcagcgcg
     3241 ggatcggcca acagggcgcg cgggtcgcgc acgtcggctt cgaccacgat cgtgtgcggg
     3301 ttgtccgcca gcagcgccct ggcgtggacg agcacaacgg ggtcgttgtc gacgtaggcg
     3361 accttggtgt ccggggcgat ctcctgggcg acctcgtgca cgttgttctg cgtcggcagc
     3421 cctgtcccga tgtccaggaa ctgggtgatg ccacagcccg cgaggtagcg caccacccgg
     3481 ccgaggaatg cccggttgtc cctggccatg gccctcgcct cgggcgcgac acgcaggagc
     3541 tcggcggcga gttcccggtc acaggcgaag ttgtccttgc cgtccaggaa gtagtcgtag
     3601 atacgcgcga tgctcggcac actcgtgtcg atcgccactg gtgcccgctc ccgcatgcgg
     3661 atcagggtac tgccccgttc ggcggtacgg gtcggtgtcc ttgatcttcg gtgtccggac
     3721 gtcgctggtc acgcgatcgg gcagatgtcg acagccggac ggcgcccata ctggcgacga
     3781 tcaccagcgc catcccgagg ccctccagca aggacagcgc ctggctcagc acaaggaacc
     3841 cggcgaacgc ggcgatggcc ggctccagac tcatcagcac cgcgaacgtc gctgccgcga
     3901 ttcgccgcaa cgcaagcagt tccagcgtgt agggcagcat cgaggacaac agcgcaaccg
     3961 cggcccccag ggcgagcgtc acgggatcca ccagcgccgc tcccgcggtg gccacgccga
     4021 agggcagact cagcacggca ccgatcgcca gtgcgagcgc cagtccgtcc gccttcggga
     4081 accgccggcc ggtgcgcgcg ctgagcagga tgtaggccgc ccacaggact ccggccgcga
     4141 gcgcgaacag gaccccctcg acatttagac tgtcgaagcc gccccggccc agcaggatca
     4201 ccccggccag cgccagcccg gcccagacca ggctggccat ccggcgcgcc gccagcaccg
     4261 acaaagtcaa cggccccagc acctccagcg tcaccgccgc gccgagtgga atgcgctcga
     4321 tcgcctggta gaagagtgcg ttcatgccgc cgagggccac gccgaacgcg gcgaccagcg
     4381 cccagtccgc ccgcgcgtgc ccgcgcacct tcggccggca gatgagcagc agcaccaccg
     4441 ccgccagtgt caaccgcagg gacaccactc ccatcgcacc ggccctgggg aacagcagtg
     4501 cggcgatcgc cgccccgaac tgcagcgaca ccgcaccgcc gaggacgagc gcgaccgaac
     4561 cgagctgcga gccgtcgccg ggacgccgga cagtgcgacg ggcagcggag cgccaggagg
     4621 gagccggagt cggggtcagt ggggagtcga gccgaacagc agtcacacca tgcacggtag
     4681 gcagcggaaa tccgcacgtg aaatgccggt tgtttagctg ttatgcttcg cgtgcatgac
     4741 cattgagctg cgtcacttcc gctgcttcct cgcgatcgcc gaggaaggca acgtgacgcg
     4801 cgcggccggg cggctgcacc tcacccagcc cgcggtctcc cgcacgttgc gccaactgga
     4861 acaacaactg ggtctgcgcc tggtcgaccg ctccacgcac cacctgcggc tcaccgacga
     4921 cggcctcgcc ttccgcgaca aggccgcgac ggtggtcgcc gctgcggacg acgcactcga
     4981 cacgagacga ctgcgctcat ggcccctgcg catgggccat gcctgggccg ccgcgggcgc
     5041 cttcaccagc acgctgttgc gacgctggga gcacgcccat cccgacactc ccttggagtt
     5101 gctgcggatc gacgaccgga cggcgggact gaccacggga caggtggacg tcgccctgct
     5161 caggggcgtg gtggatgccc ccggcctggt ggtggaaccg ctgctcaccg aacccagggt
     5221 cgcggcgatg cccgcggaca gccccctcgc ggagcgggcc gaactctcgc tggccgactt
     5281 caccgaccag accgtggccg tcaacaccat ctccggtgtc accaccccgc acctctggcc
     5341 accggagatt cggcccgccc gcacgatgac cgtggccaac accgacgact ggctggccgc
     5401 catcgccgcg aaccgggcgg tcgggatcac cacctcggcc acttccgacc tgcaccgcta
     5461 tcccggggtc gtctaccggc cgatggtcga cgctccggag atcccggtcg tgctcgcctg
     5521 gcgccggatg cccggacacc ccgcgatccc cacactcgtc gccctgttcc gggacgtggt
     5581 cggcgagggc aggacggaca gaaaaccgga caagtcttga gggttatgca caactcggat
     5641 gacgggaagg acccccgctc cggcacgctg ttccgccgca gtaggggctg ctcgcggcga
     5701 ccgagtgcgg gtgagctatt ggtgtagccg cacccgcgtg cgtgcataac acgcaattgc
     5761 acaagcctac ttgtgagcgc ccgattcact ggcaaactga cttctcatgc ggaaatcacg
     5821 actgatcgtt gtcctgtccg ccctcgccct ggctgtctcc tcgttcggcc tcgcgcaccc
     5881 cgcgaccgcc gcaccggaaa cctcgggcac gacctccgct ccggacacca tgcgtggtgg
     5941 ccggatcgat ccccatccca gtacagccga gctgacccgc gaactacagc ggctgcagtg
     6001 gcgtagccgc ggcgcggtcg acgtgtccga gatcggccgc tccaaccaga accgcccggt
     6061 gtggagcgct cgggtcggca acgggccact gcgcatcatg tacgtgaccc agcagcacgg
     6121 caacgagcca ctgggcaccc ccgccgcgct gaagttcctg gagaccaccg gagtcgggca
     6181 gagcgcgtgg caacggtggc tgcgctccag ggtcaccgtg gacatcatcg tcagggccaa
     6241 cccggacggg tccgaactga actggcgata caactacgat cccgaagccg atccggagta
     6301 cggcgaagcc ggcaagggat acgacatcaa ccgctaccac agccccattc tcgcccctga
     6361 ggacaacccg gccacggaag ccgggttgat ccagcggcac tacgccgagt tcgagccgga
     6421 catcatggtc gactaccaca tgcagggccg gtacgccgac gccgacggcg aggagatcac
     6481 cgcatcggtg atgtggccga cgcgtccgga cgtgcgggca gacatggtgc gcctggccaa
     6541 gcaggtgtcc gtggtcgcgc agcgcgccat ggacctcgcc ggggccaatg tctcgcagta
     6601 cccaggcggg aactacgaag gcattgcccg caacgcctac gggctgcgcg gcagcggcag
     6661 cgtgctgatc gagttcagcg cgatgggccc cgagcatgat cggcagcaga tcgcctcggc
     6721 atgggtttcg atgatcggca tcgcgcagag cggggcgagc gggtcgttgc agcgagtcga
     6781 ccccacctgg gccgagcgga ttccaccacg cggcgagccg atccggaccc aggcggcgag
     6841 cgcgctcgcg agccacggcg actgacgaag cctcgggcac catccgtgcg gcgccgaaaa
     6901 ttcgatcctc tttcggcgcc gcacggttct agaatgagat atggccgaac tcgacggctt
     6961 tcccctgacg aacctgctga tctacgccgt ggtagcagtg gctcccacgc tcgtgttctg
     7021 gatcgcgctg tccgcgatgg cggccactcg ccgtaggcgc aggcctgccg gcgagccggt
     7081 tcaccggccg atccaggaac tggccgcgga cctgcggcgg gtgcaccgcc tgctcctcga
     7141 cttcggcccc ggtacgcccg ccgcacgacg gaagggaacc cgtcaggctt acgatgcgct
     7201 gctgatccag gcgtgcgccg cggtcgaggt ggaacacgaa ctcgccgtgc tgcccgaggg
     7261 tgtcgaccgt gaagtcgaac gcctccgtgt ggaggaggca ctgcgcggcg cggggctggc
     7321 gatcccgtga cgcacggggg cgggtcacac ttcgccgggt ccgagtagcc gccgaggtcc
     7381 cggcccctgc ctgccgagtt cgtcacgtgg gttggcgagc ccgcaccggt cgagcgagag
     7441 gcaaccacac ccgacgcagt cggtgaagct gtccctgatc tgctgcaggt gccgaatcct
     7501 cgcgtccact tcggaccgcc agcgcttcga cagccgctgc cagtcctttc ggttgggggt
     7561 tcgcccgtcc ggcagctcgg ccagcgcgcc cctgacctcg gcgagcggaa ttccggcccg
     7621 ttgggcaatt ctgatcaacg ccagcctgcg cagcgtatcc cgccggtacc gccgctggtt
     7681 tcccgacgtt cgcctgctct cgatgagctg ctggcgctcg tagaagtgca gggccgaaac
     7741 cgcgaccccg ctgcgcgcgg cgagctgccc cacggtgagc tcggccttgg tccacgcggg
     7801 ctcttccatc atcgaccacc actgtctcgg ggccgcccca accgggcagc gacattccat
     7861 attgcttgag gtttacgcgc gatccccggg ttggtcaacc ttccttgacc tctaccaata
     7921 tcgagctttt agagttgtgt tcaccggggt ttccggtgtg cacagccagc gagaggaaca
     7981 gaatccgatg ccacagcgga actcagcaga cgccgtactc gtcatcggcg cgaccggcaa
     8041 cgtcggcagg caggtggtgc accaactgct tgaggcagga gcgacggtgc gcgcgatggc
     8101 caggaatccg aacacggcgg cgctgccggg ggatgccgag gtcgtcgcag gtgacctcac
     8161 cgaccccgcg accgtcgcgg cagcggcgaa aggcactcgc gcggccttcc tggcctggcc
     8221 cttcttcacc ggcgaggcgg ccccggccgt gctggaggcg cttcgccctg acgtccgtca
     8281 cgtcgtgtac ctgtcatcgg caggcgcaga cgaagccgac ggccctgtgg ggttccatta
     8341 cgaactggag caacagatca cgcattctgg tctggaatgg acattcttgc ggccgagcgg
     8401 attcgccacc aacacactgg gctgggccga ccagatccgc caggcggacg tcgtccgatg
     8461 gccgtacggc aaggcctccc gatccctgat ccacgagtcg gacatcgccg ccgtcgccac
     8521 cgcggcgctg accggccaag gacacgccgg gaaagtttac gacctcagtg gccctgagca
     8581 gctgacccag atcgaacagg tcgacgcgat cggcgccgcg atcggacgca agctgcacta
     8641 cgaggacgtg tcgcgcgaaa gagcacgccg ggaactgctg gccgaatggc cggacgagtt
     8701 cgccgaaggc gcactcgatg cctgggccga gttggtcacc gccccggagc cgatcacgac
     8761 aggagtgcgc gacgtgatcg gcaggccgcc ccgaaccttc cgggagtggg ccgtcgatca
     8821 cgcggaagac ttccgctccg agcgcgtcgg ctgatctctc ggtgaagtag cggggcgctg
     8881 gcgctagtgt ctgcggtgat gatcgagcag ctgagcattc ccaccgcggc gggccacttc
     8941 gacgcgatcg cttccgggcc caccgagggc aggccggtac tgctgctgca tggctttccc
     9001 gaggcaggga tcgcctggga gcaccaggtg gccgctctcg gtgggcacgg gtaccgcgcg
     9061 gtcgcgcctg accagcgtgg gtactccccc gccgtccggc ctgagcggac cggtgactac
     9121 gacatgagcg aactggtcgc cgacgtactg gcgatcgcgg acgctctgga gtggaatcgc
     9181 gtggacctcg cgggccacga ctgtggcgcg ggggtcgcct ggacggtcgc cgagcaacat
     9241 cccgaacggg tgcgctcgct cacggccgtc tcgatgcccc atcccgccgc gctggcggac
     9301 gcccagcgga ccgatgagga ccaagcactg cgctcgggtt acctcaccga ttggcggcag
     9361 accagaacca ccgagcgacg gatgctcgac aacgacgcgg aggcgctgcg acggatgttc
     9421 gagtggcggg tcccgccgag ccgagtcgag gagtacgtgc agcggctgac cgagccgggc
     9481 gcgttgaccg ccgccctgaa ctggtaccgc gccaatcgac ctggtgcccg tatcggaccg
     9541 gtttccgtac cgacgctcta cgtctggagc accgatgacg tcgccttcgg ctcgacggca
     9601 gccctcgaga ccggcaactg ggtcaccggc ccctaccact tccacatgct ggaggacgtt
     9661 tcccactggg tgccggagga agcggcagga gcgatgagct ccttactgct ggaacagctg
     9721 aacacacact gaacacgctc tgcgtagtcg gctccgacct ttcacccgca tgcgcgggaa
     9781 aggaccggat acagcggctc ctttcattac ccataccgcc atcggcatgg ccagcactgc
     9841 gccgaacgga ccacgactgt gttctgagcg ctagcacagt gctactttca gtactgctcc
     9901 ggttactcct aatgctggcg ccgaacgggg gaatatcgtg acctcgcgca acagtcacta
     9961 cgaccaagtg ggcgcaacgg ccgcgaaact gttggcggat atgcgatccg acccttccgg
    10021 tgacttctct ccctcgatct acgaaacggc ccgtctggtc gcgctcacgc catcgttgcg
    10081 cggacatcgg cggcggcttc ggtttctcct ggaccaacag cggcccgacg gcagctgggg
    10141 cgggccggag ggctactccc tgattccgac gctgagcgcg atcgatgcac tgcttgcggt
    10201 gctacaacac gagaactcga accgggaccg cggcacaggc gacgtcgccg gcgcgctggg
    10261 ccgcggactg cactggctca gaggacacct cgaacccggc gcgggtacgg cactgccgga
    10321 caccgtggcg gtggagatgc tggctcccgg cctggtctcg gcgatcaacc tccggctgga
    10381 ccagttggcg gccctggcac cggtcggcgt cgaagtggga tggggcgcgg cgcgcctgcg
    10441 ccctccgcct gagtccaacg aagcgttgct cgaccgggtt cgcgtcgccg tcctcgatgg
    10501 acgcagcctg ccggtcaagt tgctgcattc actggaggtt ctcggcgcgg acactcgcga
    10561 cgcgaccgtc cccgtcgcgg aatccggtgg tgtcggctgc tcccccgccg ccacggccgc
    10621 ctggctcggt gacgaccggg tccgccaggg gcacccttcg gtgcggtatc tggaggaagt
    10681 gcaggagccg cacagcggcg ctgttcccgt ggccgctcca ctcggcctct tcgaacgcgc
    10741 gtggatactc ggcacgctcg gcagcaccgg aatcaccaag ttggctccgg agagtctgct
    10801 ggacagcctg cgaaacgggc tcggggaagc aggagcagca ggcggtgacg gactgccgcc
    10861 ggacgcggac gacacggccg ccgcgctgca cgcactggca ctgcacggag aggccagagc
    10921 tgccgatcca ttgtggactt actggaccga ggagggcggt gggcacgtca gttgctttcc
    10981 cggtgaacgc acgccttcga ccagtacgaa cgcgcatgcc ctgcaggcct tcgccacttc
    11041 ggcggagccc gccgacgttg atgtacagcg gcggggtgtc gcgatccggt ccatcgtcga
    11101 ctggctgcgg gagcagcaga cacgggaagg gtactggacg gacaagtggc acgcctcgcc
    11161 ctactacgcc acggtgtgct gcaccgtggc gctggcggaa cacggcggga ccgccgcggc
    11221 cccctcggtc gccgccgccg tgcgctgggt gctcgagacg cagcatccgg acgggtcctg
    11281 gggccgctgg tcgggaacct acgaggagac cgcgtacgcc gtgcagatcc tcctgcgcac
    11341 cggccttccg gtcgatgagg cgaccgcgtt ggccgcggcg cgtggttgca gattcctgat
    11401 cgccaacgcc gatctgacgg aacatcctgc cctgtggcac gacaaggacc tgtacacacc
    11461 gacaagaatc gtgcgcaccg aaggcctcgc cgcattgcac gtggccaggt cggacccgcg
    11521 cacggccgca ctgctgcacg aagacggtga cggcagtgcc cgcgagcctg cggggagggc
    11581 ggtgtgctga acggcgtcga acttcgcctt gcactgcgca cactgccgtt cctggacgcc
    11641 agatccgacc tgccggaggg aatgctcgac ctgcgccagg gaccgcacgc caaactgctc
    11701 gtctggcacc ccgacgcgat cgatcggatc ttccgctctg atcggcgact gcttcatccc
    11761 ggcagcaaca gtctcatgcc cctgttcggc gcgggctcgc tcctgtgggc cgacggtgaa
    11821 cgccacgccg cctaccgccg ggcgctgggc ccacccctgc gtggcaagcg gctcactgtc
    11881 tacgagggac tcatttcccg cattacccac gaagcactgg acgagctgtc ggcaggctcg
    11941 ctggtcgcgc tgcccgcgtg gtcgagacgg atcgcgctgc gggtcgtcgc ggccatcgtt
    12001 ctcggtgccg cgaacgacac cgtgctcgtc ccgttcaccc gctggatcga cagggcactc
    12061 ggttcccggc gcaggacgct tgcctaccgc tacctccgcg gcggcctgcc gcgctcgtct
    12121 gccgaactcg accggtccct gatccgccag gcgaaggtgc accgcggcgg cctgccaccc
    12181 accctcgccg cggtgatgct ctccggagaa ggaccgctcg gcaaggtcga tgacgaggag
    12241 ttgcgcgacc agttggtgtc gctgctgttc gccggacacg agaccaccgc atcggcgacg
    12301 gcgtggacgc tgtaccacct cgcccgtgat cgtcagctca ccgccgccgt ccgcgcggaa
    12361 atcgaggccg cgggcgacgg cggtgccgat gccggccgtg ttccgctgtt gcaggccgtg
    12421 atccaggagg cgctgcgcct ggcaccaccg gtcacggtcg cggagaaccg cacgctcacc
    12481 gaggacaccg agctactcgg ccggaccctg cccgcgggca ccaccctgac ccccagcatc
    12541 tacctcgcgc accggcgaag ggacagcttc gccgatcccc gccggttcga ccccgcacgt
    12601 ttccttgaca ccaaggcgag tccgcagcgc tacctgccct tcggcggtgg aagcaggcac
    12661 tgcctcggca gcgggctcgc acagctggag atccgaatga tcacggccgc ggtgctgggc
    12721 aggctggact gggagtgcgt caatccccgg gccgctgtcc ccgagttgcg tggacacgcg
    12781 atggcgccgt cagcgaagct acgaatgcgg gtgacgggat gccgggcctg acgcgaacgc
    12841 caacacgagg gctgtggggg gacctggtcg tcctgcaccg gctcgaacac cccctgcccg
    12901 tcatgtatgt ctgctacgcg tcctggggag cctgttacgc cacgggcgac gtccggggac
    12961 tgctgcatcc gccggtgctg ctcgcgattc tggcaaacct gctgctgctg atcggcgggc
    13021 tcgcactgaa caacatcgtg gacgtcccga cggaccgaca gcacaaggac aaggcctacc
    13081 tttcctccgc agcactgcgg gtcggtgagc aaaaggcact gtggctggcg ctgaccgaga
    13141 cggctgctgg cctcattctg tccattgtgg tatctgtggt cactgggcgc tggatcgtcg
    13201 ccgcgatggc actgggcata gcgctgctgc acgtgctcta caacgtacga cccgtcagac
    13261 tgaagggccg cggcctcgcg ggatccatcg cgtttggact gtcggtggtc gccctgccgt
    13321 ccctgctctc ccacggtgcg gtgagccaga ccctgccagg gtgggtgctg gcggtcctcg
    13381 ccggagcgag cgtgctcgcc gtcggccgaa cggtgtggtg gtcggccccg gaccgcgctg
    13441 cggatctgat cagcggtgtg gccactcccg ccgcccgcta cggcgtgccg cgcacgctcg
    13501 tcctgtcctg cctgatcctg ctgtccggcc tggtgctact cggcggtggt ctgtgggcac
    13561 acttcgggtt cgtcacagtc gtcgcagggg cactcgcgca cgcggtgttc accggtaccg
    13621 ccgtgttcca actgctccgc gccaccaggg gaatcgcacc gaccgcatcc gccatgcgca
    13681 ggcatgccct gctgctggtg ctggcgggtg agctgtcgat cgccctggtc ccgttgctgg
    13741 cgtcctgaga ctcagacctt ccggccgaga cccgcgtgca cgcgcaccaa ctcgggattg
    13801 cgcacctgct cgtcgccggg ctctggatgc cacaggggga ccggaacgat gccgggctcg
    13861 actatctcca ccccgtcgaa gaagcggacc agttcgccgg ggtcgcgcag cttcaccgcc
    13921 ggcggtgcgc cgaacatccg gctgaagagg gtgagcccct catgcagttg gtcgtcctgg
    13981 ctgaagtgag agatgccgag gtagctgccg gacggcaccg catccatgta ggcggcaacc
    14041 agtccggccg ggttttcgga atcctgcagg tgcagcagaa actcgatcat caggacggcg
    14101 accggctctc cgaagtcgat caggtcggtg acctcgggcg cgccgagcac ctcgtccggc
    14161 ctgcgcacgt cggcgcgtac gaacgccgcg ttgccggttc cggcgaggag gtcggcgctg
    14221 tcctgcgcga tcgtcggatc aagatcgaca tagacgatct tggcctccgg atcgacctcg
    14281 tgggccacac ggtgggcggc gttgatgtcg gggacgcctg agccgaggtc gaggaactgc
    14341 cgcacaccac ggtcggtcag ataccggacg agcctccgga cgaacgcgtt ctgcgcccga
    14401 acgagatacg gcaggtgcgg ggcgcagacc acgatctggt cggcgaaccc gcggtcggcg
    14461 tcgtcgtgat gggtgccgcc gagccatgag tcccggatac gggcaatgct cggatgcgcc
    14521 acgtccacct cgcctgcatc gggacctgcg gcgtcggacc gggtggatcc gggctgcgcc
    14581 ggaccgccgg gaagtgccac gttgtgccgc tccctccgag aacaacctgc tcggcctatc
    14641 gtggacgatc ttcagccggt cagggcacga gataatactg cagttcgatt tcactgggga
    14701 catacctgac gacgacgtca cactatcgtg aatccgcccg aatcccgtga cgctgagttg
    14761 atcagcgtgt tgatcaaccg gcccgggacg ccagcggcgt cggcgcgcga accctgtgac
    14821 actgggacgt gaccggcgca agccggagag aggatggatc ggatggctgc ctcggtgaac
    14881 ccggatcgat cggagtggga cgtcatcgtc ctcggcggag cggcggcggg tgagaacgcg
    14941 gcccagtacg cgacgcagtt ctccgggctc gacgcggtgt tggtcgagaa tgcgctggtg
    15001 ggaggcgagt gctcctattg ggcgtgcatg ccgagcaagg cgctgctgcg ccctgtcgag
    15061 gtgctcgaca ccgctcggca cctgcccggc ctcgcctccg tcgtcgaagg gctacgcctc
    15121 gatgtcgacg aagtgctcgc gcgacgtgac aagatcgtca gcaatcttga tgacgcggga
    15181 caggtgcgct gggccctcgg cgccggcatc gatgtcgtgc gcgggtacgg caggctgacc
    15241 ggtgcgcgca ccattgaggt gactggtgct gacgggaccg tgcgcaccct catcgcccgg
    15301 cacgcggtcg tgctggacac cggctccgcg gcctcgatcc ccccggtccc cgggctgcgc
    15361 gaggcgctgc catggacctc ccgcgacgtg accaacctgc acgagatccc ccggcgggtg
    15421 gtgatcctcg gcggcggagt ggtcgcctgt gaggcggcga cctggctgta cgggctcggg
    15481 gtggacgaac tgacgttggt caaccggggt ccccagctgc tcgcgggcaa cgaaccgttc
    15541 gccggcgaac tcgtggccga ccggttgcgc aaggcgggtg tgacggtgca cgcggaacgc
    15601 acgatgtccg aggtacgacg ggaggacgtg cgggacagcg gcgtcggcag gatccacggc
    15661 ggcgaggtga aggtgaccct ggacgacggc accatgctca ccgccgacga gatcgtcgtg
    15721 gcagcgggac ggaagccgaa cagcgatgac atcggcctgg acaagctcgg cgtgtccccc
    15781 ggtggctatg tcgacgtcga cgaccagcag gcggtgcgcg gggtcggcgg ggagtggctg
    15841 tacgcgatcg gtgacctctg cgggagggcg ctggtgaccc acatgggcaa gtaccaggcg
    15901 aggatcgtcg gcgaggtgat cgcggcgcgg gccaagggcg agcagctcga actgggcgag
    15961 tacggcaggc atacggcagc cgccgggcat cggaccgtgc cgcaggtgac cttcaccgac
    16021 ccggaggtcg gttcggccgg actgaccgaa cagcaggcgc gggagcagga catcgacgtc
    16081 gagaccgtgg agtacgacct cgccgccctc gcggggacgt tcttgctgcg tgaggactac
    16141 tcggggcgcg ccaagctggt gctcgaccgt gcgaaggaca cgatcgtcgg cgcgacgttc
    16201 gtcggaaccg gtatcgccga tctcgttcac tccgcgaccg tggccatcgt cggcaaggtg
    16261 cccgtgtcgg cgctgtggca cgcggtgccc agctacccga ccccgagcga ggtgtggctc
    16321 cgactgctgg aaaccctcaa cgccgaccgg cgtggcggct cggcgtgaac cgatgagacg
    16381 ccgacagcca gccccactgc cgcagcggga cggcctcgac cccgctcgaa tgcggatgcc
    16441 caccgagggt gcgtgggcaa ccatccgcga ccacctggtg gaccggattc ccaagctcgc
    16501 gcccacccgc atcgacgaga tgttctccga gcgccggttc ttcggcgagc acgggcctct
    16561 cgacgcggac gcgcctttcg tgcccggctc ggtgatctgg ttccaccggg acctgcccga
    16621 cgaggttccg gtgccgttcg agatcgacgt cgtgcaccgg gacgagaacc tgctcgtggt
    16681 ccacaagcca cacttcctgg cgacgattcc gcgcgggcag cacattgtcg agaccgcgct
    16741 cgtgcggctg cggcgtgatc tggacctacc gctgctcagc ccggcgcacc ggctggaccg
    16801 ggtcaccgcg gggctggtga tgtgggtgat ccgcccggag tatcgcggcg cgtatcagaa
    16861 cctgttccgg gaccggctcg tgcgcaagga gtacgaggct gtcgcgccct tcgaccccgc
    16921 gctggatctg ccccgcacgg tgcgcagccg gatcgtgaag gaacgtggcg tgatcaccgc
    16981 tcaggaggtg ccggggacgc cgaacagcga gaccacggtg gaactgatcg agcactccgg
    17041 cggactcggg cgttaccgcc tactgcccgc gaccggccgg actcatcagc tccgcctgca
    17101 catgagcaac ctcggtgtgc ccatcctcgg cgatgacttc tacccggtgc tccacgaaac
    17161 cccgctcgac gatttccgca ggccactgca actactggcc agaacactcg agttcaccga
    17221 tccactaacc ggtgagccgc ggcggttcga gtcgccgggc gagctgcagg cgtggaccga
    17281 cctggccggg tggtcgggca cacaggatgg acaacactcg atagagtgac gtgcatcgct
    17341 gaaacctttt catcattcgc cgcacgagga gagccgatgc ccgaaccgaa ggaccccgag
    17401 ttcgttcccg agggcgtcga cctcgagcgg ccgaaccccg cgcggatcta cgactggttc
    17461 ctcggcgggt ccgcgaactg ggcgatcgac cgcgcgttcg gggagaaggt gctggaaacc
    17521 ttcccccagg cgcgcaccat cgccagaacc ggcagggact tcctcggccg cggcgtgcac
    17581 tacctggccc gccagggcgt gacccagttc ctcgacctcg gctccggtgt gccaaccgtc
    17641 ggcaacgtgc acgagatcgc cgagtcggtg aacccggaca gccgttgtgt ctatgtcgac
    17701 aacgaggctg tcgcggtggc acactcccgc gtcctgctgg agaagcacgg cgagtccagc
    17761 aggcacgccg tgctgcacgg cgacctccgg cagcccgacg acatctggaa gcgggcactg
    17821 gcaaccggtg tgctcgatcc cgagaagccg atcggactga tcgtcgtcgg cgtgctgtac
    17881 ttcctcggcc cggaggacga cccgcacggt gtcatcgccc gttaccgcga cctcctgccc
    17941 tcgggctcct acctgctttc gtcacacctg accgaggacg aggttcccga cgagggcggc
    18001 accgagcgcg aagaggtccg ccagcagtac cagcgctcca gctcccagct gtacatgcgc
    18061 aaccgcgagg agttcaccgc cttcttcgac ggtttcgaac tcgtcgagcc cggcgtggtc
    18121 tggctaccgg aatggcgcct cgacgagcgc gagtccaagg ccagccgcaa atacgcgaac
    18181 accccccagg aaagcagctc aatcggcgca ctgggccgaa agccctgacg tgattgcgtt
    18241 ctgcgcgcgg gtgtttgcgg tttagagacg cgtgttgggg tttcgggcac gccttcggcg
    18301 caccctgcgc aatccagcca accccaccca ctggacaaaa accacttgag ccgcgcccgt
    18361 ccactgcacc agcgtctacc ggccgaccgc gtaccccatt ccccggacgg tcgagatcct
    18421 gtcggcaccg agctttcgac gtagcgcgcg cacgtagacg tcgacgatgt tggagccggg
    18481 gtcgaagtcg taaccccaga cgtgcgacag aatctgctcc cgggacagca cctgacccgg
    18541 gtgccgcagg aacagttcga gcagggtgaa ctcccgagcc gtgagttcca cggtcgtttc
    18601 gcccacctgt gcacgccggg tgcgcaggtc cagcgacaga tcggtgacgc gcaacaacgt
    18661 cgcctccggc gtgttgtccg ccctgcgcag ccgcagccgg acccttgcca gcagttcctc
    18721 gaagcggaac ggcttggtca tgtagtcgtc ggctcccccc tccagaccag cgaccgtgtc
    18781 ccgcacggag tcgcgggcgg tcaggatgat caccgggatg ctcactcgtg cctcacgcat
    18841 cgaccggagc acgctgaagc cgtcctgatc cggtaggccg atgtccagga tcatcaggtc
    18901 gaacgaaccg ccgcgggcca gttcgacggc gctcgtgccg tcgccgacaa cagtagtggc
    18961 gaaaccgttg gccgagagtc cctttcggac aaaggaggcg atccgctcct cgtcctccac
    19021 caccagaatt ctgttcactg caccccttct ccacgcgccg gcagttcgag tccgaacgtc
    19081 gcgccgccac cagaggtcgg cacgagcctg acgcctccgt gatgcgcacg ggcgatggcc
    19141 tgcacgatgg cgagacccag ccctgctcca cccgacgtcc gcttcgcgtt actacctctg
    19201 gcgaaccggt cgaaaatcac cgctgcgtcc tcctgggaga cgccggggcc tcggtcggcg
    19261 atccagaacg aggcccagcc ccggtaaaca ctcgaaccga gcaagatctc gccatcggtc
    19321 tcggtgtgct gcacggcatt gtgtgccaac tgaaccacgg cctgcgtgac tcgctgctcg
    19381 tccaacatga ccctgccctc gccaatcgac tccagccgcc agcgccggtc gccaagtgcc
    19441 cggatcttcg cgtagatgtc gctggtcagc tcggcgacct ccaccggttt cagctggacg
    19501 aagtccgggc gttccgcctt ggcgagcagc agcaggtcgt ccacgatgcg gctcatccgg
    19561 tccagttcgt cggtgcacac ccgcacggcg gccagccgtt cgtcgggatc atcgttcacc
    19621 gggtcgagca gttcgaggtg gcctcggatg atggtgatcg gagtgcgcaa ctcgtgcccg
    19681 gcatcgtcga ggaattcccg ctgggtggcg aacgccttct ccaggcgttc cagcatcgcg
    19741 ttgaactgct cggccaacgc cgcgaactcg tcgttgccct cgactggaac gcggcgagtg
    19801 aagtcgtgct ccgtgatgtg cgccgcagcc gcacgggcca acctgaccgg tgccagtatg
    19861 cgtccggcca ccagccaaga agctcccgcg gtaaggatca aaccgagcag gctgaccagc
    19921 ccgagggtcc ggatggtccg gtggacctcg gcccgatccc ggtcgatgaa atacccgacg
    19981 acgaagatgc cttcagcacc ctgccccgcc gggccggtcg ccgtgacctt cacccaccgc
    20041 atctcccccg ctgccgtccc gatgctgcca ctggtcgagg tcgcggccag gatcggatcg
    20101 agcagttccg gccgatcgta caggcgcatc ggtgcttccc gttcctgccg caacacctcc
    20161 cgtgcggcgc cgtttcgaac cacgcccacg atgacctcgt catcgtcggg gtactgccgc
    20221 tgcaggtgat tgcgcagcaa ctcgcggacg ctgccgaacg gctggcccgt cgcccggtcc
    20281 acaccggacg ccgcgacacc ggagaactcc cgcgcttcct gttccagtgc ggcgaccgca
    20341 gaagactcgg cctggtgcag cagcagattt cgggtgacca cggcgaccga gagcagcacc
    20401 acggccatca ggaggatcaa ccagcccatg atcctggcgc gggcaggcag accacgtcgc
    20461 ctggtccgcc gcgctggtgc gctcccgacc accggaagtg ttctcggctc agtcgtcgtc
    20521 ttcgtcgtca tccccgtcgt cgtcgctgtc gtcgtcctgg tcgtcgtcat catcatcgct
    20581 tatgggcgga ggtggcggga cgacctgcat ggtcgaggtg cccggtgcgg gctccgactg
    20641 ctgggtgccg gacggcccca gcctgctgtc cccgccgtct ggaccttcga cctgcccgat
    20701 ccgcacctgc gcaggcacgt ccggtggcgg gacgtcctcg gtcagcacgt agctggccag
    20761 cgctgccgtc agtggcaccg cgatgacggc cagcggaacc gtcagccgcg cggcgagttt
    20821 catgagccca tcgtgtcgcc ggcctggcac acggaggtga ggcggagatg aaaatttctt
    20881 catctccgcc tcgcctcctg tcgacccggt gggtcaggcc gggctgtccg ggctgtccgg
    20941 gctgtccggg ctgtcagccg ggatgtcggg gctgtcgggg ctgtcggggc tgtcagccga
    21001 gtccggccca tccggaagtt cagccgcgga ggccgcggaa tcgacgggcg actcgccggg
    21061 ggagtccgcc gactctggcg agtcgtcatt ccccacgttg tccgcagccg tcatgggctc
    21121 gtagtccgcg aggtgaaccg tcggtgccgg cctcggctcg ttgagcgcag caggctccga
    21181 cgccgccgcg acagccgtgc cgaaccccgc caccgcgagc gttgcgccga cgactaccca
    21241 tggcctcgtg atcttcatca gtgatctcct tactgttgtt ggtgattcca cgatctcttc
    21301 cggacatgag gtgaactgcc gcttcacatg aagggctttt cacctctccg cgcgtggggg
    21361 tgacccgttc gtcggctcca gccacgtctg cgcgagagca acgcggtcct cggtccgggc
    21421 aagccagtcg gcctggccca accggtgcgg cccggtcgcc agcgacagcg ctaccgccgc
    21481 ggctcgcctg gacagtgcgg cggggtcaag ttcgcggacg aaccgcaggt acagccgcga
    21541 caccagccgg tcgaggtccg gtgccgcatc cggacgcagt tcggcgagca
//
