LOCUS       NZ_FOKG01000001        22580 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Amycolatopsis marina strain CGMCC 4.3568, whole genome shotgun
            sequence.
ACCESSION   NZ_FOKG01000001
VERSION     NZ_FOKG01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Amycolatopsis marina
  ORGANISM  Amycolatopsis marina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900111885.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:41:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,708
            CDSs (total)                      :: 6,643
            Genes (coding)                    :: 6,572
            CDSs (with protein)               :: 6,572
            Genes (RNA)                       :: 65
            rRNAs                             :: 3, 3, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1 (5S, 16S)
            partial rRNAs                     :: 2, 5 (16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 71
            CDSs (without protein)            :: 71
            Pseudo Genes (ambiguous residues) :: 0 of 71
            Pseudo Genes (frameshifted)       :: 22 of 71
            Pseudo Genes (incomplete)         :: 62 of 71
            Pseudo Genes (internal stop)      :: 4 of 71
            Pseudo Genes (multiple problems)  :: 15 of 71
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:06:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 133331
            Orig. end                         :: 155911
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOKG01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22580
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="2"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22580
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22580
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12580](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12580)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    529..543
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 21.84"
                     /tool="antismash"
     misc_feature    974..986
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            complement(1288..2214)
                     /locus_tag="BM199_RS00630"
                     /old_locus_tag="SAMN05216266_101126"
     CDS             complement(1288..2214)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005460140.1"
                     /locus_tag="BM199_RS00630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101126"
                     /product="glutamate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_245788126.1"
                     /transl_table=11
                     /translation="MSALAVVVAGCGSPGAPVDPAPVGSVARPMPANAGPVEVDVEGTT
                     TGDCDATASLSPQDGIPGGSTMDEIRERGYLVAGVDQNTFLFGFRNPTTGTLEGFDVDM
                     ARAVAKAIFGDPDKVRFRAVTSAQRIPALEAGDVDIVVRTMTITCDRLKKINFSSVYYV
                     AGQRILVDENSDVRSLADLADRKVCASKGSTSLKNIAKAEPGPIPVQVDDWSDCLVMMQ
                     QGQVEAISTDDTILAGMAQQDPTTKIVGERFTEEPYGIGIPKDDEDMVRFVNAVLEDVR
                     GGEWQKIYDRWLKGPLGAAQPPAAKYK"
     gene            complement(2277..3638)
                     /locus_tag="BM199_RS00635"
                     /old_locus_tag="SAMN05216266_101127"
     CDS             complement(2277..3638)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330836.1"
                     /locus_tag="BM199_RS00635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101127"
                     /product="hypothetical protein"
                     /protein_id="WP_245788127.1"
                     /transl_table=11
                     /translation="MEPASRRDPGAKSGVAGMLDLPGQAYRSVVRSASSTPGRLSVIAV
                     GLVVLALLTALVGAFAVQDKKDTIDGLIDHREPLAAAAQEVYRSLSDADATAASAFLST
                     GAEPPELRSRYEQDIARAGAALAKAASDSAGVPAAAEQVDVISQRLPVYTGLVETARAN
                     NRQGFPAGASYLREASELMRATILPAAESLYRIDTERLFAEQDDATDFPWFTALLTFGL
                     LGALVYTQIHLRRRTNRVFNVGLVIATVAVGIAILWSTVAMTVQSVLVSSGSEDGTEQV
                     DVLVRARIAALQARADETLTLVARGGDSDYEEEFSQLAAQFAGPDGQSGLLQEARDRTD
                     GQEATEHLDRARENATAWLAAHAEVRELDDTGDHASAVTMAIDGQDEASAAAAFYRLDN
                     DLSEAIGVARQTFLDDTTNGSRALILLTPGFAVLAVIAALGATMGIRERLLEYR"
     gene            complement(3899..4102)
                     /locus_tag="BM199_RS00640"
                     /old_locus_tag="SAMN05216266_101128"
     CDS             complement(3899..4102)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222289.1"
                     /locus_tag="BM199_RS00640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101128"
                     /product="cold-shock protein"
                     /protein_id="WP_091669503.1"
                     /transl_table=11
                     /translation="MTQGTVKWFNSEKGFGFITPDNGGGDVFVHYSEIQGNGFRSLDEN
                     ARVEFEIGQGQKGPQATSVSVI"
     misc_feature    complement(4106..4126)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.56"
                     /tool="antismash"
     misc_feature    complement(4115..4128)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.22"
                     /tool="antismash"
     misc_feature    complement(4120..4129)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     gene            complement(4244..4426)
                     /locus_tag="BM199_RS00645"
                     /old_locus_tag="SAMN05216266_101129"
     CDS             complement(4244..4426)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BM199_RS00645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05216266_101129"
                     /product="hypothetical protein"
                     /protein_id="WP_091667906.1"
                     /transl_table=11
                     /translation="MSTDTTQQDAAGRSGVAPVRFSAPEGTADTTQGDALHSTEARDAM
                     RRSPFGKDGNAAQGE"
     gene            complement(4499..5395)
                     /locus_tag="BM199_RS00650"
                     /old_locus_tag="SAMN05216266_101130"
     CDS             complement(4499..5395)
                     /EC_number="1.14.19.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016717 - oxidoreductase activity, acting
                     on paired donors, with oxidation of a pair of donors
                     resulting in the reduction of molecular oxygen to two
                     molecules of water [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) delta9_cd03505"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156081.1"
                     /locus_tag="BM199_RS00650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101130"
                     /product="acyl-CoA desaturase"
                     /protein_id="WP_245788128.1"
                     /sec_met_domain="delta9_cd03505 (E-value: 9.4e-103,
                     bitscore: 340.9, seeds: 90, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAAPRPTSEHVLVTVFVLLPLLALVAAVPFAWGWGLSWVDVGLG
                     ALFFVVTGLGVTAGFHRHFTHGSFKAKRPLRIALAIAGNMAAQGPTTTWVADHRRHHAF
                     SDRAGDPHSPWLFGTGPAALAKGFWHAHMGWLFSRDVTNAERFAPDLVADSDLRTVDRL
                     FPVWTVATFLLPGVLGGLITWSIWGGVTAVFWAGFIRVALLHHVTWSVNSICHMLGERP
                     FTSRDKAANFWPLAIVSFGESWHNLHHADPTCARHGVLRGQIDISARVIWIFEKLGWAS
                     NVRWPTPTRLDRITVAR"
     misc_feature    5579..5597
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.63"
                     /tool="antismash"
     misc_feature    complement(5777..5792)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     gene            5829..6254
                     /locus_tag="BM199_RS00655"
                     /old_locus_tag="SAMN05216266_101131"
     CDS             5829..6254
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669542.1"
                     /locus_tag="BM199_RS00655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101131"
                     /product="thioesterase family protein"
                     /protein_id="WP_091667912.1"
                     /sec_met_domain="4HBT_2 (E-value: 5e-16, bitscore: 54.9,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQQDYPHWQQVPTRWKDNDVYGHMNNVVHYSLMDTVINEWLIRAG
                     GLDIHDGDLIGLCVESHCNYHASVGFPDTLAVGLRVGRLGRSSVRYEIGIHTADRQTLV
                     ADGHFVHVFVDRAARRPKEITGQLRASLERLLIEPTP"
     gene            complement(6199..7998)
                     /locus_tag="BM199_RS00660"
                     /old_locus_tag="SAMN05216266_101132"
     CDS             complement(6199..7998)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669540.1"
                     /locus_tag="BM199_RS00660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101132"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_091667914.1"
                     /transl_table=11
                     /translation="MTKQLAGRTGETIPRLYWATLGGQWRGWVALLGCSVLESLPAFLS
                     GRLVQLSVDQGFAAGDAVSGTAWLLVFAVVAVLGAFGSRLVWQRLGTVIEPLRDTLVAA
                     VVRGVLRGGTPRRAGPDASGVARITQHVEIIRDATAGLLVQARGMVVTTVAALAGLFTV
                     AGSLAWLVAIPVTVSVVFFACLLPALARRQRTLAIADERTAEVSGQALVGIRDVVACGA
                     EPAAITEVHEAVDAQASAAIRMASAAALRTLVVATGAFFPLLLVLVLAPGMVASGQLTA
                     GAALGALVYLATTMQPALQGLAATASTVVLRLLVALRRLGEACAPEQERGVDAVPDGSA
                     ISIRGLTHRWGAKAEPVLDRVDLDLVPGDHLAVVGPSGIGKSTLASLLTGTLAPQEGSV
                     RLGGVPVGDIRPQLRHQLIAFTPQESYVFAGTVRENLALFAPLADDTDLLAAADAVGAG
                     ALVERLGGLYAELGHAGSGLSAGETQLLALARLYASPAKVVVLDEATANLDAQAEARAE
                     RAFAARGGVLVVIAHRLSSALRADRVLVMDGGPAGVASVLLGTHTELLDRSPRYAELMQ
                     AWEGPVTASARSAAAPATRAAAR"
     gene            complement(7995..9650)
                     /locus_tag="BM199_RS00665"
                     /old_locus_tag="SAMN05216266_101133"
     CDS             complement(7995..9650)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027061.1"
                     /locus_tag="BM199_RS00665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101133"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_245788129.1"
                     /transl_table=11
                     /translation="MLRALIARNPAGLGLMAGTALVATAAGLLLPGALASAVDTAISGQ
                     SSWAQVLWLLTLGVSEILAEVFGIVVTARVTHTGAAWLRHRLSRHLIRLGLRSPFPEGD
                     AISRITGDSTGAAAAPSLVVQLGSALVLSCGAIVLLALLDWRLAAVFLVSVPMAVLLAR
                     SHLRLTADDVTTYQEVSGELSARLLDAVSGLRTIAASGTAEREAERVLRPLPLLGAAGI
                     GMWRTQARMVWRAGLLLPSVQLAVLVAAGFGVLAGRLSIGDVLAALGYTMLGMGLVGQI
                     ALLTALSKARSCATRITAVLDVPVPERGKFRLPNGAGTIEVRGVGVEDVLHDIDVTVSG
                     GTHLAVVGPSGAGKSTLVAVLGGLRAPDRGEVLLDGVPLRCLPPEDIRAAIGHAFERPA
                     LLGATVRDAVAYGSWAGTASVERACRAAQVHDLVVRLPEGYDTPLADTPLSGGEAQRLG
                     LARALARAPRVLALDEATGSLDTVTEARVEDAITGLLPGRTRFAVTHRATTARRADLVL
                     WLDQGRVRALAPHLELWDDPRYRAVFTEAADEEG"
     gene            complement(9808..9948)
                     /locus_tag="BM199_RS00670"
                     /old_locus_tag="SAMN05216266_101134"
     CDS             complement(9808..9948)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949109.1"
                     /locus_tag="BM199_RS00670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101134"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_091667917.1"
                     /transl_table=11
                     /translation="MDFVLDLQNLDAPEDMSYGDPSNGGGSNLSLLASCANSTISLLTC
                     H"
     CDS_motif       complement(9880..9948)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDFVLDLQNLDAPEDMSYGDPSN"
                     /locus_tag="BM199_RS00670_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9808..9879)
                     /prepeptide="core"
                     /locus_tag="BM199_RS00670_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="12.50"
                     /molecular_weight="2093.4"
                     /monoisotopic_mass="2092.1"
                     /core_sequence="GGGSNLSLLASCANSTISLLTCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDFVLDLQNLDAPEDMSYGDPSN"
                     /leader_location="[9879:9948](-)"
                     /alternative_weights="2111.4"
                     /alternative_weights="2129.4"
                     /alternative_weights="2147.4"
                     /alternative_weights="2165.4"
                     /alternative_weights="2183.5"
     gene            complement(10001..12580)
                     /gene="lanKC"
                     /locus_tag="BM199_RS00675"
                     /old_locus_tag="SAMN05216266_101135"
     CDS             complement(10001..12580)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010312157.1"
                     /locus_tag="BM199_RS00675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101135"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_091667919.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1162.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.1e-10, bitscore: 37.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.6e-07, bitscore: 27.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.4e-13, bitscore:
                     44.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRYEAFCFADPLFFDEQRRSDTEEDEFAAALPLPRAGWHEGNK
                     GTWRMLAPDDVILPGQGWKIHVSACLGNAETVLATVYEYCVQRRIAFKHLRTKTVLLAR
                     NSKYAPRDSSGKLITIYPADDEALTQVLAELSDQLAGQPGAYILSDLRYGDGPLYVRYG
                     GFAEQWVEMDGTRVLAVTKPDGTLVPDRRTPTFTVPEWVDLPECLAPHLAARKGGDPAK
                     FPYRVTSSLHFSNGGGVYRATRLADDHEVVLKEARPHAGLDRDGVDAVQRLRREHDILR
                     RLSGIEGVPEAYDLFTVWEHHFLSMEYVPGRSLGSWLPRNYPLTRVDSTEQDIVDYTRR
                     ALALVERVATLIDQVHERGVVFGDLHPLNIMVDGEADERVSVIDFEMAFAAEETGRPAL
                     GAPGFRAPADRTGFDIDAHALAALRLWVFLPLNALLELSPAKLAGLVDSIERRFPLPDS
                     YGDEIRAALTPRGKDVPAPVAHEFDQPEPDWGVVRKSLATAILASATPHRTDRLFPGDI
                     EQFRVGGTCFGYGAAGVLHALDAAGAGRFPEHERWLIDAVHRDPPTRPGFFDGAHGIAH
                     VLENLGHQDEADRLLADAEGLVAQTRDHSFDGGLSGIGLNLLHFAETRRDGGLLTRAVT
                     IGERLAEALAADQEPGDFARAGLLNGWSGPALLFVRLFEHTGDRGWLVDADRALARDLR
                     ECVVTDDGSLQVRDRGARTLPYLGIGSAGVALVAEELAAHSPTAECLGSQDELLRACRG
                     EFVIHPNLVLGRMGLLAALAAANRRDPNPEFAASVSLHLSRLAWYAIPYGEDGIALPGN
                     QLLRLSMDLNTGNAGVLLALAATLDGHGRVLPFLGAGYSLTAPVPSP"
     misc_feature    complement(12569..12584)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.75"
                     /tool="antismash"
     misc_feature    12848..12868
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.53"
                     /tool="antismash"
     misc_feature    complement(12882..12894)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            12992..13357
                     /locus_tag="BM199_RS00680"
                     /old_locus_tag="SAMN05216266_101136"
     CDS             12992..13357
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005460146.1"
                     /locus_tag="BM199_RS00680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101136"
                     /product="hypothetical protein"
                     /protein_id="WP_091667922.1"
                     /transl_table=11
                     /translation="MITGFAVAVALTSLAVAGWSFVLVLRNRAPQRPLLIGLAVIEALL
                     VAQLVIAIVLLISGERPGSMATFLAYLIGSLLVLPIGTAWALAERTRSSTAVLGVACLT
                     VPVLILRMSEVWGGAGA"
     gene            13350..13781
                     /locus_tag="BM199_RS00685"
                     /old_locus_tag="SAMN05216266_101137"
     CDS             13350..13781
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669535.1"
                     /locus_tag="BM199_RS00685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101137"
                     /product="hypothetical protein"
                     /protein_id="WP_091669509.1"
                     /transl_table=11
                     /translation="MPESAAENPEVPAVGATASGPGRVLIAIYAIFAVGATSRAAVQIA
                     TRFGEAPLAYVLSAFAAVVYLLATLALARSGLAWWRVALAACSVELVGVLTVGTLTVFD
                     AAAFPDATVWSNYGRGYLFIPLVLPVIGLLWLRRTAPSR"
     gene            complement(13709..14140)
                     /locus_tag="BM199_RS00690"
                     /old_locus_tag="SAMN05216266_101138"
     CDS             complement(13709..14140)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006238727.1"
                     /locus_tag="BM199_RS00690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101138"
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="WP_091667924.1"
                     /transl_table=11
                     /translation="MQVAKLGELERAVMDVLWGHRESMSVRAVHGELAGRNLAYTTVMT
                     VLTRLASKNVVHRERSGRAWLYFPKVSRDEYVAGLMLEALAMTGDRDSALVHFAHSVST
                     AEADALRAALVPQVMPQREGAVLRNQSRPITGSTSGMNR"
     gene            complement(14217..15872)
                     /locus_tag="BM199_RS00695"
                     /old_locus_tag="SAMN05216266_101139"
     CDS             complement(14217..15872)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783701.1"
                     /locus_tag="BM199_RS00695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101139"
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_218160271.1"
                     /transl_table=11
                     /translation="MPDSPREDAPTLRGLLVAIGEPLVDLYVANAWLDAQVRDVTILDP
                     DDELGSYSGELVLIIGARGREAVRFVRAAARRGAVAAAVKVDAQVGPETQGGLHELRAA
                     ASEAGIALLAVRPRVRWEQLETLVREVLDAAALSAGLGSEGGTGDLFALAQTVAVLTAG
                     SVIIEDAGNRVLAYSRSDDEVDELRRLSILGWEGPESYLAMLREWGVYQRLRDGEVVHI
                     DEHPEVGIRRRLAVGIRAGAQYLGMIWVQQGREPFAERAESALLGASRVAAAHLLRYRA
                     GSSPGNRSQQELVSGLLDGRSSPDLVAGHLGLDPATPAVVAAVTAPAEPDHSARELHKA
                     EMLNVVSVHATAYRRSALVGAIGTRVYAVLPGVPLGAVEPALVTLAEDITAVLRRRTGA
                     SVQVGIGAPVLGLGKVVRSRSEADRVLEVMARDPQRSVATIAELRGEVLLGEVLTLLEA
                     AEDLRDPGVSALVEHDRAHGTELVVSLLAFLDALGDVRSAANALHVHPNTLRHRVRRAG
                     SISGIDLTEPRERQFCHLQLLLVVTRAEQGNHAQ"
     gene            15993..17621
                     /gene="pruA"
                     /locus_tag="BM199_RS00700"
                     /old_locus_tag="SAMN05216266_101140"
     CDS             15993..17621
                     /EC_number="1.2.1.88"
                     /GO_function="GO:0003842 - 1-pyrroline-5-carboxylate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006562 - proline catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pruA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075672.1"
                     /locus_tag="BM199_RS00700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101140"
                     /product="L-glutamate gamma-semialdehyde dehydrogenase"
                     /protein_id="WP_091667927.1"
                     /sec_met_domain="Aldedh (E-value: 9e-104, bitscore: 343.2,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDAITTTPAPRNEPVRDYAPGSAERESLSAKLTELAGQHTELTLT
                     IDGEQRPGGGRQIDVVQPHRHSHVLGTMGNATQEDAKAAVESSLRAADSWRRLPFDERA
                     AVLLRAADLLSGPWRDTLNAATMLGQSKTAIQAEIDSACELADFWRFNVHFARQIQQEQ
                     PVSSPGMWNRLDYRPLEGFVYAITPFNFTAIAGNLPTAPALMGNTVVWKPSPTQGLAAH
                     LTMRLLEEAGLPPGVINLVTGDGLDVSEVALTDPALAGVHFTGSSRTFQHLWSTVGANI
                     SGYRTYPRLVGETGGKDFVLAHQSADVDVLRTALVRGAFEFQGQKCSAASRAFVPRSVW
                     NRMRDDLVSEVESLAVGDVTDFRNFMGAVIDRRSFDKLAAAQRLAHEESTLDVIAGGTA
                     DDSEGFFVRPTVVVGTDPTHEVFNTEYFGPFLAVHVYSDGDFDKVLQQVDQGAAYGLTG
                     AVIAQDRAAIARASEALRFAAGNFYVNDKPTGAVVGQQPFGGARASGTNDKAGSIYNLL
                     RWISPRTIKETFVPPVNSGYPHQGE"
     gene            17623..18549
                     /locus_tag="BM199_RS00705"
                     /old_locus_tag="SAMN05216266_101141"
     CDS             17623..18549
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157066.1"
                     /locus_tag="BM199_RS00705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101141"
                     /product="proline dehydrogenase family protein"
                     /protein_id="WP_091667929.1"
                     /transl_table=11
                     /translation="MLRSALLAAAKSPACRSLVENAPPVRPIVDRFVAGGGLDDAVRAA
                     KELSTDRLVSLDHLGEDTTDREQAGATVSAYQALLRALGEHGLAERAEVSVKLSAVGQA
                     LPVDGEKIALDNVRQICATAAAVGTMVTVDMEDHTTTDSTLSIVRDLRVDFPSTGAVLQ
                     AYLRRTESDCAELVGPGSRIRLCKGAYDEPESVAFRDKTEVDASYVRCLRTLMAGQGYP
                     MVATHDPRLIAIAEHLAGKAGREHADFEFQMLYGIRPEAQELLAARGHRMRVYVPYGAE
                     WYPYFMRRLGERPANIAFFLRSLLTKG"
     gene            complement(18571..18822)
                     /locus_tag="BM199_RS00710"
                     /old_locus_tag="SAMN05216266_101142"
     CDS             complement(18571..18822)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156757.1"
                     /locus_tag="BM199_RS00710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101142"
                     /product="Prokaryotic metallothionein"
                     /protein_id="WP_091667932.1"
                     /transl_table=11
                     /translation="MDVCEVCGNTYDQSFEIHTRDGAKHTFDSFECAIHQLAPICEHCR
                     CRVIGHGVEVDGHFFCCAHCSRQSSVGSEKARDKVSTG"
     gene            18861..19163
                     /locus_tag="BM199_RS00715"
                     /old_locus_tag="SAMN05216266_101143"
     CDS             18861..19163
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018225197.1"
                     /locus_tag="BM199_RS00715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101143"
                     /product="glutaredoxin domain-containing protein"
                     /protein_id="WP_245788054.1"
                     /transl_table=11
                     /translation="MTAYVRLETPGDEEATMTAPDVDQLTVYGAGWCPDVRRSRALLDR
                     EGVAYSYVDVESDEAAAEAVRRLQGGPRRIPTVVWPDGTHLVEPSDADLSAALRR"
     gene            complement(19176..19964)
                     /locus_tag="BM199_RS00720"
                     /old_locus_tag="SAMN05216266_101144"
     CDS             complement(19176..19964)
                     /NRPS_PKS="Domain: ECH (7-253). E-value: 3.7e-37. Score:
                     119.9. Matches aSDomain:
                     nrpspksdomains_BM199_RS00720_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670101.1"
                     /locus_tag="BM199_RS00720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101144"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_091667935.1"
                     /transl_table=11
                     /translation="MSHRVTVERDGHVLLIGVDRAAKRNAWDLRTISELSAAYDRLAED
                     DELRVGVVHGHGEHFSAGLDLTDVFPAVREHGPGALSGDGKHDPFGLWKEPVGKPVVLA
                     VQGIAFTLSIELALASDIVVAADDVRFRQLEIGRGIIPFGGATLRAPAQLGWGNAMRFL
                     LTGEEFGAAEAHRIGLVQEVVPAGTQLERAKELAALIAAQAPLGVQGTLANARVALRSG
                     SEHEAAEHLRGLLPGIVGSADAEEGVRSFVERRQAEFTGR"
     aSDomain        complement(19206..19943)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM199_RS00720_ECH.1"
                     /evalue="3.70E-37"
                     /label="BM199_RS00720_ECH.1"
                     /locus_tag="BM199_RS00720"
                     /protein_end="253"
                     /protein_start="7"
                     /score="119.9"
                     /tool="antismash"
                     /translation="ERDGHVLLIGVDRAAKRNAWDLRTISELSAAYDRLAEDDELRVGV
                     VHGHGEHFSAGLDLTDVFPAVREHGPGALSGDGKHDPFGLWKEPVGKPVVLAVQGIAFT
                     LSIELALASDIVVAADDVRFRQLEIGRGIIPFGGATLRAPAQLGWGNAMRFLLTGEEFG
                     AAEAHRIGLVQEVVPAGTQLERAKELAALIAAQAPLGVQGTLANARVALRSGSEHEAAE
                     HLRGLLPGIVGSADAEEGVRSFVE"
     gene            complement(20025..21014)
                     /locus_tag="BM199_RS00725"
                     /old_locus_tag="SAMN05216266_101145"
     CDS             complement(20025..21014)
                     /NRPS_PKS="Domain: PKS_ER (12-325). E-value: 2.5e-34.
                     Score: 110.8. Matches aSDomain:
                     nrpspksdomains_BM199_RS00725_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009942408.1"
                     /locus_tag="BM199_RS00725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216266_101145"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_091667937.1"
                     /sec_met_domain="ADH_N (E-value: 2.6e-09, bitscore: 32.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.8e-19, bitscore:
                     65.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAIRQHEFGPADRLRQEEVQDPAPAEGQVRIRVAVAGVHLLDTT
                     IRSGTNGGPFPLPELPMTPGREVAGVVDELGAGVDGYWLGKRVVAHLGPASGGYAELAV
                     VAASSLHELSAEVDFAAAVAMIGTGRTAVGILHVAALSADDVVLVPAAAGGIGTLLVQE
                     ARRVGAMVIGLARGQDKVELIRSLGADAAVDYSGEDWSATVRSTLDGREPSVVLDGVGG
                     TVGQTALEMLGIGGRVITFGWSSGEPIRITTEILYSRGLTAAVAVGPRLLRRPGGLRGL
                     ETESLAALAQGRLSPVVHEPFPLAEAASAHAALEGRATTGKVVLTPNR"
     aSDomain        complement(20040..20978)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BM199_RS00725_PKS_ER.1"
                     /evalue="2.50E-34"
                     /label="BM199_RS00725_PKS_ER.1"
                     /locus_tag="BM199_RS00725"
                     /protein_end="325"
                     /protein_start="12"
                     /score="110.8"
                     /tool="antismash"
                     /translation="DRLRQEEVQDPAPAEGQVRIRVAVAGVHLLDTTIRSGTNGGPFPL
                     PELPMTPGREVAGVVDELGAGVDGYWLGKRVVAHLGPASGGYAELAVVAASSLHELSAE
                     VDFAAAVAMIGTGRTAVGILHVAALSADDVVLVPAAAGGIGTLLVQEARRVGAMVIGLA
                     RGQDKVELIRSLGADAAVDYSGEDWSATVRSTLDGREPSVVLDGVGGTVGQTALEMLGI
                     GGRVITFGWSSGEPIRITTEILYSRGLTAAVAVGPRLLRRPGGLRGLETESLAALAQGR
                     LSPVVHEPFPLAEAASAHAALEGRATTGKVVL"
     CDS_motif       complement(20325..20357)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BM199_RS00725_0002"
                     /evalue="1.10E+00"
                     /label="PKSI-ER_m5"
                     /locus_tag="BM199_RS00725"
                     /protein_end="230"
                     /protein_start="219"
                     /score="2.3"
                     /tool="antismash"
                     /translation="VGGTVGQTALE"
     CDS_motif       complement(20529..20582)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BM199_RS00725_0001"
                     /evalue="5.90E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="BM199_RS00725"
                     /protein_end="162"
                     /protein_start="144"
                     /score="9.4"
                     /tool="antismash"
                     /translation="DVVLVPAAAGGIGTLLVQ"
     misc_feature    21023..21037
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.16"
                     /tool="antismash"
     misc_feature    complement(21055..21075)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.51"
                     /tool="antismash"
     misc_feature    complement(21105..21119)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.6"
                     /tool="antismash"
     misc_feature    21137..21152
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.78"
                     /tool="antismash"
     misc_feature    21178..21192
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    21236..21250
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    21575..21591
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.94"
                     /tool="antismash"
     misc_feature    complement(21993..22008)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 26.14"
                     /tool="antismash"
ORIGIN
        1 caggctgtcc ttgtacttgc tggtgtaccc ggtgaactcg aagctcagca cggccagggt
       61 acggccgacc gtgtagaggt ccgaggccac cgacgcaccc tgcttggcca gctccggtgc
      121 gctgtaaccg gtggtgaaga acagcgggct ctcgtagtcg tccatccggc ggaccgcgcc
      181 catgtcgatc agcttgagct gctcgtgggt ctggatcacg ttgtccggct tgaggtcgca
      241 gtagagcagt ccctgaccgt gcagatatcc gagtgcgggc aggatctcca gcccgtaggc
      301 aatcacctgg ccgatcggca gtggctccgc ccggccggtc tccctgtggt gcgcgagcgc
      361 gagctggcgc agcgactgcc cgcccacgta ctccatcacg atgtagccga ccgtggtgcc
      421 cgagtgggcg tccgggtgct gcacgaagtt gtagatcttg acgatgttgg ggtgctcgac
      481 ctcggcgagg aagcgctgct cgttcaccgc cgcggccatc gccgtcgcat caccggtgtc
      541 gatcagtcct ttgaggacga cccagcgatc gctgacgttg tggtcctgtg ccaggtagat
      601 ccagccgagg ccaccgtagg ccaacgcgcc gaggacctcg tactgaccgc ctacgatctc
      661 gcgcggccgc agcttcggaa tgaaggagaa gggggtgcca cagttggcgc acacgccctc
      721 gcgcgcaccc ggctcaccgt ccttgccgcg gcccaccttc gcgccacact tgctgcagaa
      781 gcgcttctcc tccgacacca cgggatcggc aagcaccgcg gaggccggat cccggtaggg
      841 cacctgcggc acctcgacca gtcccgcgcc caggcgtcca cgccgagact tgcgggagga
      901 cgtgcgccgg gacgtgccgg gaaacgcgcc ggagccggtg cccgatcccg taccagatcc
      961 ggttccgcta ccggtgccac tgccactgcc acggcccgaa ccgggatgga tgccatcgct
     1021 ggtgctgctg ggcagcacgc tttcggtgcc ggggtccggc agcaccagcg ggttgactgc
     1081 ctgggtcggg ggtggtggct gaatgctctg ggtcgcgggc gcgggaacgg acagcacact
     1141 ggtcggctgt ggttccgcgc caggttgcgc gacctggggc agctgccaga gcgcaggtgg
     1201 acgctgcggc tgcgacgagg acacgccatc cgcgtcgggt acggcatgcc gtggctgctg
     1261 cggcttatcc gtcactactt gtcaccccta cttgtacttc gcggcgggcg gctgcgcggc
     1321 accgagcgga cctttgagcc agcggtcgta gatcttctgc cactcgccgc cccggacgtc
     1381 ctccagcacg gcgttgacga agcgcaccat gtcctcgtcg tccttcggga tcccgatccc
     1441 gtagggctcc tcggtgaacc gctcgccgac gatcttggtg gtcgggtcct gctgggccat
     1501 ccccgcgagg atcgtgtcgt cggtggagat cgcctccacc tgcccctgct gcatcatcac
     1561 caggcagtcc gaccagtcgt cgacctggac gggaatgggc cctggctccg ccttcgcgat
     1621 gttcttcagc gaagtggatc ccttgctggc acacaccttc cggtctgcga ggtcggcaag
     1681 gctccgcaca tcggagttct cgtcgacgag gatccgctgc cctgccacgt agtagaccga
     1741 ggaaaagttg atctttttga gccggtcgca ggtgatggtc atcgtgcgca ccacgatgtc
     1801 gacgtcaccg gcctccagtg ccgggatgcg ctgcgccgag gtgacggccc tgaaccggac
     1861 cttgtcgggg tcgccgaaga tcgccttcgc cacggccctt gccatgtcga cgtcgaaccc
     1921 ctcgagagtt ccggtggtcg gattgcggaa tccgaagagg aacgtgttct ggtccacccc
     1981 ggcgaccagg tagccacgct ccctgatttc gtccattgtg gagccaccag ggataccgtc
     2041 ctgcggcgag aggctcgccg tcgcatcgca gtccccggtg gtggttccct cgacgtccac
     2101 ctcgacggga ccggcgttgg ccggcatcgg ccgcgccacc gaacccaccg gagccggatc
     2161 caccggggcg ccgggggacc cgcagcccgc gacgaccact gccagcgccg acatcagcgc
     2221 cacgagccgc ttcacccgaa cactcctcac ccgcactgaa ctcgcctgtc cccggctcat
     2281 cgatactcca gcaggcgttc ccggattccc atggtggctc cgagtgccgc gatcacggcc
     2341 aggaccgcga atcccggcgt cagcaggatg agagcacgtg agccgttggt cgtgtcgtcg
     2401 aggaaggtct gcctggccac cccgatggcc tcggagagat cgttgtcgag gcggtagaag
     2461 gccgcggccg cgctggcctc gtcctggccg tcgatcgcca tcgtcaccgc gctggcgtga
     2521 tcgccggtgt cgtcgagttc gcgcacctcg gcgtgcgccg cgagccaggc ggtggcgttc
     2581 tccctcgccc ggtccagatg ttccgtggcc tcctggccat cggtgcggtc gcgggcctcc
     2641 tgcagcagtc cactttgccc gtccggcccg gcgaactgcg ccgccaactg actgaactcc
     2701 tcctcgtagt cggagtctcc gcccctggcc accagggtca gggtctcgtc ggcgcgcgcc
     2761 tgcagtgcgg cgatcctggc ccgcaccagc acatcgacct gctcggtgcc gtcctcgcta
     2821 ccgctgctga ccagcacgct ctgcaccgtc atcgccactg tgctccacag gatcgcgatc
     2881 ccgaccgcga cggtcgcgat gaccaggccg acgttgaaca cccggttggt ccggcggcga
     2941 agatggatct gcgtgtagac cagcgccccc agcagaccga acgtcagcag tgcggtgaac
     3001 caggggaagt cggtcgcgtc gtcctgctcg gcgaagagcc gctcggtgtc gatccggtag
     3061 aggctttccg cggcggggag aatggtcgcc cgcatgagtt ccgaagcctc acgcaggtag
     3121 gaggccccgg cggggaagcc ctgccggttg ttggccctcg cggtctcgac aaggccggtg
     3181 tagacgggca gccgctggct gatgacgtcc acctgctcgg cagccgcggg gacaccggcc
     3241 gagtcggacg cggccttggc gagcgcggcc ccggccctgg cgatgtcctg ctcgtaccgc
     3301 gagcgaagtt cgggaggctc ggcaccggtc gagaggaacg cgctcgcggc cgtcgcatcg
     3361 gcgtcggaca gcgagcggta gacctcctgc gcggccgcgg ccagcggttc gcggtggtcg
     3421 atcagcccgt cgatggtgtc tttcttgtcc tgcacggcga acgcgccgac cagcgcggtc
     3481 agtagcgcga gcaccaccag tccgaccgcg atcaccgaga gcctgcccgg tgtgctgctc
     3541 gcggagcgca cgaccgaccg atacgcctga cccggcaggt cgagcattcc ggcgaccccg
     3601 gactttgccc caggatctcg gcggcttgcg ggctccatgg cggcgccggc gggcggcccg
     3661 gaacccccat ggttcccggc gcgggtcgcg gtgctcgtca tcgtgtccat cctcccagtg
     3721 ccgacaccgg atgaaggtat ccgagagcgc gtggccacga gacggttacc tccgcattgg
     3781 ggcggagttg atgcagtgag acgctccgcg cgcgcccgtc tcccgccacc accccatcca
     3841 aagcagcgga gccgccacct cgtgcgaggt ggcggctccg ctggttaagg cgttggggtc
     3901 agataacgct gaccgaggtg gcctgggggc ccttctggcc ctggccgatc tcgaactcaa
     3961 cgcgggcgtt ctcgtccaag gaacggaagc cgttgccctg gatctccgag tagtgcacga
     4021 agacgtcgcc gccgccgttg tccggggtga tgaagccaaa ccccttctcg gagttgaacc
     4081 acttgacagt gccctgcgtc atgaaaaatc tcctgtatga caaaaaataa aaggatgaca
     4141 tcagctccgg gaagccgtcg ctgacgtcgt aataagtcaa gcacacccgg tcagtaaaag
     4201 ccaatgtttt ccagccgaac gggtgtgtga taaccctctt gcgctattcg ccctgagcgg
     4261 cgttgccgtc cttgccgaac ggcgaccgcc gcatggcgtc ccgcgcctcg gtggagtgga
     4321 gcgcgtcacc ctgggtggtg tccgccgtgc cctccggcgc gctgaaccga accggggcga
     4381 cgcccgatcg gccagcggca tcctgctgtg tggtgtctgt ggacatgtgt tctcccaatc
     4441 gagaatgacg ggcgctactg agcgcgcccg gaagatgttg cgaggctcgc gtcgaggctc
     4501 agcgcgccac tgtgatgcgg tcgagcctgg ttggcgtcgg ccatcgcacg ttcgaggccc
     4561 agccgagctt ttcgaagatc cagatcaccc gcgcggagat gtcgatctgc ccgcgcagta
     4621 ccccgtgcct cgcgcaggtg ggatccgcat ggtgcagatt gtgccacgac tcgccgaacg
     4681 agacgatcgc cagcggccag aagttggctg ccttgtccct gctggtgaac ggccgctcgc
     4741 cgagcatgtg acagatcgag ttcaccgacc acgtgacgtg gtgcagcagc gcgacccgga
     4801 tgaagccggc ccagaagacg gcggtcacgc cgccccatat ggaccaggtg atcagcccgc
     4861 cgagcacgcc gggcagcagg aaggtcgcga ccgtccacac ggggaacaac cggtccaccg
     4921 tgcgcaggtc gctgtcggcg accaggtcgg gggcgaagcg ctcggcgttg gtcacgtccc
     4981 tgctgaacaa ccagcccatg tgcgcgtgcc agaaaccttt ggccagtgcg gccgggccgg
     5041 tcccgaacag ccacggcgag tgcggatcgc ccgcccggtc ggaaaaggcg tggtgcctgc
     5101 ggtggtcggc gacccaggtg gtcgtcggcc cctgcgcggc catgttcccc gcgatcgcga
     5161 gcgcgatccg cagtggacgc ttggccttga aggaaccgtg ggtgaagtgc cggtggaagc
     5221 ccgcggtcac gccgagaccg gtcaccacga agaacagggc accgagaccg acgtcgaccc
     5281 agctcagtcc ccaaccccag gcgaagggca ccgctgcgac gagcgccagc aacggcagca
     5341 gcacgaacac ggtgaccagc acgtgctccg acgtcggacg cggcgcggcc agcatgggct
     5401 tcggtttacg ggcggctggg ggttcgggcc tggtcggtgt ctcggttgcg gacatgcaca
     5461 cctctggttt ttctggcgcc cgaaatcagg ccaccgcgaa tttgcgaata ggcttgacaa
     5521 agccaccgca cgaatcgcgt cagggcttac gtcaagagca ggacttgtca attgcacgaa
     5581 agtgaattca gaaaccgcgc atttcctgcg cagccgcccc accgacaaat gaagttctca
     5641 ttggggcgct ggggtctaac ccacgccgtc ggggtggctc cgatctacca agcggtcgtg
     5701 ccgctaacct gcctacgcct tcgacggtac ccgatagcca gaccagacgc catggccaca
     5761 ccctgcgacc tgtgggtgag atcgcggtca cacccgcctc ggccgcgacc gtgggttagc
     5821 ttcaggccat gcagcaggac tacccccact ggcagcaggt ccccacacgg tggaaggaca
     5881 acgacgtcta cgggcacatg aacaacgtcg tgcactactc gctgatggac accgtcatca
     5941 acgagtggct gatccgcgca ggcgggttgg acatccacga cggcgatctc atcggcctgt
     6001 gcgtggagtc gcactgcaac taccacgctt cggtgggctt tccggacacg ctcgcagtcg
     6061 gcctgcgggt cgggcgtctt ggccgttcca gcgtccgcta cgagatcggt atccacaccg
     6121 ctgaccgcca gacactggtc gccgacgggc acttcgtcca tgtcttcgtg gaccgggcag
     6181 cccgcaggcc gaaggagatc accgggcagc tgcgcgcgtc gctggagcgg ctgctgatcg
     6241 agccgacgcc gtgaccggcc cctcccaggc ctgcatcaac tccgcgtagc gcggcgagcg
     6301 gtcgagcagt tccgtgtggg taccgagcaa caccgacgcc acgcccgcgg gtccgccgtc
     6361 catcaccagc acccggtccg cccgcagtgc cgaactgagc cggtgcgcga tcaccaccag
     6421 caccccgccc ctggctgcga acgcgcgctc ggccctggcc tccgcctgcg catcgaggtt
     6481 cgccgtggcc tcgtcgagta cgaccacctt cgccggtgac gcgtacagcc tggccagcgc
     6541 gagcagctgg gtctcaccgg cggacagccc agatcccgcg tgcccgagct ccgcgtagag
     6601 cccgccgagc cgttccacca gcgcgccggc gcccaccgca tcggccgcgg cgagcaggtc
     6661 ggtgtcgtcg gcgagcgggg cgaacagcgc caggttctcc cgcacggtcc cggcgaagac
     6721 gtaggactcc tgcggggtga aggcgatcag ctggtgccgc agttgcggtc ggatgtcacc
     6781 cacgggcacc ccgcccagcc gcacactccc ctcctgcgga gcgagcgtgc cggtcagcag
     6841 actcgccaat gtcgacttac cgataccgct gggacccacc acggcgaggt gatcgccggg
     6901 cacgaggtcg aggtccacgc gatcgagcac cggttcggcc ttggctcccc accggtgcgt
     6961 gaggccgcgg atcgagatcg cactgccgtc cggaacggcg tcgacaccgc gctcctgctc
     7021 cggtgcgcac gcctcgccga gcctgcgcag cgcgaccagc agtcgcaaca cgacggtgct
     7081 cgcggtggcc gcgagaccct gcagcgcggg ctgcatcgtg gtggccaggt agaccagcgc
     7141 gccgagggcc gcgcccgccg tgagctgccc ggacgccacc atccccggcg cgagcaccag
     7201 caccagcagc aacgggaaga acgccccggt cgccaccacc agcgtgcgca gcgcggcggc
     7261 cgaggccatc cgtatggccg cactcgcctg cgcgtccacc gcctcgtgca cctcggtgat
     7321 cgcggccggt tccgcaccac acgccacgac gtcacggata ccgacgagcg cctgtcccga
     7381 gacctccgcg gtccgctcgt cggcgatcgc cagcgtccgt tgtctgcggg cgagagcggg
     7441 cagcaggcag gcgaagaaca ccaccgacac cgtcaccggg atcgccacga gccaggccag
     7501 cgaccccgcg acggtgaaca acccggccag cgccgccacg gtcgtcacca ccatcccgcg
     7561 cgcctgcacc agcaggcctg ccgtggcgtc ccggatgatc tccacgtgct gcgtgatccg
     7621 agcgactccg ctcgcgtccg gccccgcgcg ccggggtgtg ccgccgcgca gcacaccccg
     7681 cacgaccgcc gcgaccagcg tgtcgcgcag cggctcgatc acggtgccga ggcgctgcca
     7741 gaccagccgg gaaccgaacg cgccgagcac cgccaccacg gcgaagacca gcaaccaggc
     7801 ggtgccgctg accgcgtccc ccgcggcgaa cccctggtcc accgagagtt gcaccagccg
     7861 accggacagg aacgcgggca ggctctccag gacagagcag ccgagcaggg cgacccagcc
     7921 acgccactgc ccgccgaggg tcgcccagta caacctgggg atcgtctcgc cggtgcggcc
     7981 cgccagctgc ttggtcatcc ttcctcgtcc gctgcctcgg tgaagaccgc tcggtaacgc
     8041 gggtcgtccc agagttcgag gtgcggagcc aatgccctga cccgtccctg atcaagccag
     8101 agcaccaggt ctgcccgccg tgccgtggtc gcgcgatgcg tcaccgcgaa ccgagtccgt
     8161 cccggcagga ggccggtgat cgcgtcctcc accctcgcct cggtgacggt gtccaggctt
     8221 ccggtcgcct cgtccagcgc gagcactcgt ggcgcccgtg ccagtgctcg ggccaggccg
     8281 agacgctggg cctcgccgcc ggacagcggc gtatcggcca gcggtgtgtc gtacccctcg
     8341 ggcagccgca cgacgaggtc gtgcacctgc gcagcccggc acgctcgctc gaccgaagcc
     8401 gtgccggccc agctgccgta ggcgacggca tcgcgaaccg tcgcgccgag cagcgcggga
     8461 cgctcgaagg cgtgcccgat cgcggcgcga atgtcctccg gcggcaggca gcgcaacggg
     8521 acgccgtcga gcagcacctc gccacgatcg ggtgcacgca gtccgccgag caccgcgacc
     8581 agcgtcgact tgcccgcgcc ggacggaccg acgacggcga ggtgggtgcc tcctgacacg
     8641 gtcacgtcga tgtcgtggag cacgtcctcg acgccgactc cgcgcacctc gatcgtgccc
     8701 gcgccgttcg gcaaccggaa cttcccgcgc tcggggacgg ggacgtcgag cacggccgtg
     8761 atccgggtgg cacaggaccg tgccttcgac aacgcggtca gcagcgcgat ctgccccacc
     8821 aggcccatac cgagcatggt gtagccgagc gcggcgagca cgtcgccgat gctcagtcgc
     8881 ccggcgagca cgccgaagcc cgcggcgacc agcacggcca gctgcacgct ggggagcagg
     8941 agacctgccc gccagaccat ccgggcctgc gtgcgccaca tgccgatccc cgcggcgccc
     9001 agcaacggca ggggacgcag cacccgctcc gcctcccgct ctgctgtacc ggaggcggcg
     9061 atcgtgcgta gcccggagac cgcgtccagc agccgggcgg acagctcccc ggagacctcc
     9121 tgataggtcg tgacgtcgtc ggcggtgagc cgcaggtgcg aacgggcgag caggaccgcc
     9181 atcggaacgc tgaccaggaa caccgcggcg agccgccagt cgagcagcgc cagcaggacg
     9241 atcgcgccgc acgagagcac cagggccgag ccgagttgca ccacgagcga gggggcagcg
     9301 gctgcccctg tgctgtcccc ggtgatccgg ctgatggcgt cgccctccgg gaagggagag
     9361 cggaggccga ggcggatgag gtgccgggaa agccggtggc gcagccaggc ggcaccggtg
     9421 tgcgtgaccc gtgccgtgac gacgatgccg aacacctcgg ccaggatctc ggagaccccc
     9481 agtgtcagca gccacagcac ctgcgcccaa ctgctctgcc ccgagatcgc ggtgtcgacc
     9541 gccgaggcca gcgcaccggg aaggagcagt cccgccgccg tggcgaccag cgccgtcccg
     9601 gccatcaacc ccagtcccgc ggggtttcgg gcaatcagcg cacgcagcag ccgatcgcca
     9661 tcgcgacgag tgctcacgtt cgctccgttc gtccagctct tccggccgga cttgtgcgga
     9721 acagcactgg tccgccagcc gaaaaagggg agaatggcgg cgcgggagcg gcgcacttgg
     9781 cctgtgccgc tcccgcgctc ggttcgatca gtggcaggtg agcaggctga tcgtgctgtt
     9841 ggcgcaggac gccagcaggc tcaggttgct gccaccaccg ttgctcgggt cgccgtagga
     9901 catgtcctcg ggcgcgtcga ggttctgcag gtcaagaacg aaatccattg tgttcccttt
     9961 ccttgttcta ctttccaccg gtcggggtcc ggccggaggt tcatggagac ggcacagggg
    10021 ccgtcagcga gtaacccgca ccgaggaacg gcagcacgcg accgtgcccg tccagggtgg
    10081 cggcgagtgc gagcagcaca ccggcgttgc cggtgttcag gtccatcgag agccgcagca
    10141 gttggttgcc gggaagcgcg attccgtcct ctccgtaggg aatcgcgtac caggccagcc
    10201 tggacagatg cagtgagacc gatgcggcga actccggatt cggatctctg cgattcgcgg
    10261 cggccagtgc cgccagcaac cccatgcggc cgaggaccag gttgggatgg atgacgaact
    10321 caccccggca ggcgcgcagc agttcgtcct gactgccgag gcattcggcg gttggcgagt
    10381 gtgcggcgag ttcctctgcg accagcgcga caccggcgct gccgatgccc aggtagggca
    10441 gggtgcgcgc gccgcggtcg cggacctgca gggagccgtc gtcggtgacg acgcattcgc
    10501 gcaggtcacg ggccagcgct cgatcggcgt cgaccagcca gccccggtcg cccgtgtgct
    10561 cgaacaaccg gacgaacagg agcgcgggac cggaccagcc gttgagcagg ccggccctgg
    10621 cgaagtcacc tggttcctgg tcggcggcga gggcttcggc gagccgctca ccgatggtga
    10681 cggccctggt gagcagtccg ccgtcgcgcc gcgtctcggc gaagtgcagc aggttcagcc
    10741 cgataccgga gagaccgccg tcgaagctgt ggtcgcgcgt ctgggccacc agcccttccg
    10801 cgtccgcgag tagccggtcc gcctcgtcct gatggccgag gttctccagt acgtgggcga
    10861 tgccgtgcgc tccgtcgaag aagcccggcc tggtgggtgg gtcgcggtgc acggcatcga
    10921 tcagccagcg ctcgtgctcg ggaaagcgtc ccgcgcccgc ggcgtccagg gcgtgcaaca
    10981 cacctgcggc gccatagccg aagcaggtac cgccgacccg gaactgttcg atgtcaccgg
    11041 ggaacagccg atcggtgcgg tgcggggtgg cactggccag gatcgcggtg gcgagcgact
    11101 tgcgcaccac accccagtcc ggctcgggct gatcgaactc atgcgcgacg ggagcgggca
    11161 catcctttcc gcgtggtgtc agcgccgccc ggatctcgtc gccgtaggag tccggcagcg
    11221 ggaagcggcg ctcgatggag tccacgagac cggcgagctt cgccggggac aactccagca
    11281 gcgcgttcag cggcaggaag acccacagcc gcaacgcggc gagggcgtgc gcgtcgatgt
    11341 cgaagcctgt ccggtccgcg ggggcacgga agccgggtgc gcccagtgcg ggtctgcccg
    11401 tttcctcggc ggcgaaggcc atctcgaagt cgatcaccga gacgcgctcg tccgcttcgc
    11461 cgtccaccat gatgttcagc ggatgcagat cgccgaagac gacgccgcgc tcatgcacct
    11521 ggtcgatcag cgtcgccacc cgttccacca gcgccagtgc gcgccgggtg tagtcgacga
    11581 tgtcctgctc cgtggagtcg accctggtga ggggatagtt gcgggggagc cacgaaccga
    11641 gcgaacggcc gggaacgtac tccatcgaaa gaaagtggtg ttcccagacg gtgaacaggt
    11701 cgtaggcctc agggacgccc tcgataccgg agagcctgcg caggatgtcg tgttcccgcc
    11761 gtagccgctg caccgcgtcc accccgtcgc ggtcgaggcc ggcgtgcggc cgtgcctcct
    11821 tcagcaccac ctcgtgatcg tcggcgagcc gcgtcgcgcg atagacaccg ccgccgttgg
    11881 agaagtgcag ggaggacgtg acgcggtacg ggaacttggc cggatcgccg cccttgcgcg
    11941 ccgccaggtg cggtgcgaga cattcgggca ggtccaccca ctccggcacg gtgaacgtcg
    12001 gtgttcgccg gtcgggcacc aatgtcccgt ccggcttcgt gacggccagc accctggtgc
    12061 cgtccatctc gacccattgt tctgcgaatc cgccgtaccg gacgtacaac ggtccgtcgc
    12121 cataacggag gtcgctgaga atgtaggcgc ccggctggcc ggcgagttga tcggaaagct
    12181 cggcgagcac ctgcgtcagc gcttcgtcgt ccgccgggta aatcgtgatc aattttccac
    12241 tcgagtcccg cggggcgtat ttcgagtttc gtgcgaggag aactgttttc gtgcgcagat
    12301 gcttgaacgc gattcgtcgc tgcacgcagt actcgtacac ggtggcgagt accgtctcgg
    12361 cgttgcccag acatgcgctc acatggatct tccagccctg tccaggcagg atgacatcat
    12421 ccggagccag catccgccaa gtgcccttat tcccctcatg ccaaccagcc cgaggcaacg
    12481 gcaacgcggc ggcgaactcg tcctcctcgg tgtccgaccg ccgctgctca tcgaagaaca
    12541 ggggatcggc gaagcagaat gcctcgtacc gaagatccat tcgaataccc tccggaaatt
    12601 tgccccctgg ccgcttcggc ccgttcaaca ttcagtcata ccgaacccgg aaagccaatc
    12661 cgccatttca gcggttcgat tggtctgaac agggtaggaa atattgacca ccgcgaaccg
    12721 gaagacctta cttaagtagg gtttgacttc cttgcttcac ccgtatgacg tgtaacgctt
    12781 taccgttcat cgagtcggcc gagcagaaga tcgcctagcc gcccgaaaag tctgtcacat
    12841 tcaggataaa cataatgacc ggtatgttgt gttacgcaac ggcgacaact tcactgtccg
    12901 cgacgtgcgg aacccccggc cggacgtccg gccgccggga agcggtcagt aacctacgac
    12961 ccgagtagca gtacgtccgg acggaggacc ggtgatcact gggttcgcag tggcggtcgc
    13021 gttgacctcg ctggctgtcg cgggttggag tttcgtcctg gtcctgcgga accgggcacc
    13081 ccagcggccg ctgctcatcg gcctcgccgt gatcgaggcc ctgctggtcg cccagttggt
    13141 catcgccatc gtcctgttga tctccggcga gcggccgggc agcatggcca ccttcctcgc
    13201 ctacctcatc ggctcgctgc tggtcctgcc catcggcacc gcatgggcgc tcgcggaacg
    13261 gacccgttcg agcaccgccg tcctcggcgt cgcctgcctc accgttccgg tgctgatcct
    13321 gcggatgtcc gaggtgtggg gaggtgccgg tgcctgagag tgcggccgag aatccggaag
    13381 tgcccgcggt cggggccacg gccagcgggc cgggacgggt gctgatcgcg atctacgcga
    13441 tcttcgccgt gggcgccacg tcaagggcag cggtacagat cgcgacccgc ttcggcgagg
    13501 ccccccttgc ctacgtgctg tcggccttcg cagccgtcgt ctacctgctc gcgaccctcg
    13561 ccctcgcccg ttcgggactc gcgtggtggc gggtggcact cgccgcatgc agtgtcgagc
    13621 tcgtcggcgt gctcaccgtc ggcacactga ccgtcttcga cgccgcggcg ttcccggacg
    13681 ccacggtgtg gtcgaactac ggccgtggct acctgttcat cccgctcgtg ctgccggtga
    13741 tcggcctgct ctggttgcgc aggaccgcgc cctcgcgttg aggcatcacc tgcggcacca
    13801 gcgccgcgcg caacgcatcg gcctcggcgg tgctcaccga gtgggcgaag tggacgagcg
    13861 ccgagtcccg gtcaccggtc atcgccaagg cctccagcat cagccccgcg acatactcgt
    13921 ccctgctcac cttcgggaag tacagccagg cgcgaccgga ccgctccctg tgcaccacgt
    13981 tcttcgacgc gagtctggtg agtaccgtca tcaccgtcgt gtaggccagg ttccggccgg
    14041 ccagttcccc gtgcaccgcg cgcacgctca tcgactcccg atgcccccac aacacatcca
    14101 tcaccgcacg ctcaagttca ccgagcttgg ccacctgcac ccctcttgcc ggtcatcagc
    14161 gctggcggaa agccgccacg atcatcttgg catcgcgact cggccctgca tgccgcctac
    14221 tgggcgtggt ttccctgctc cgcccgggtc actacgagta gcaactggag gtggcagaac
    14281 tgccgttccc tcggctcggt caggtcgatt ccgctgatcg agccggccct ccgcacccgg
    14341 tggcgcagcg tgttcgggtg cacatgcagc gcattcgccg cggatcgcac gtcccccagc
    14401 gcgtccagga aggccagcag cgaaaccacc agctcggtgc cgtgcgccct gtcgtgttcg
    14461 accagcgcgg acaccccggg atcgcgcagg tcctcggctg cttccaggag ggtcagtacc
    14521 tcgccgagga gtacctcgcc gcgtagttcg gcgatcgtcg ccacgctgcg ttgcggatcg
    14581 cgggccatca cctccagtac gcggtcggcc tccgacctcg aacgcaccac cttgccgagc
    14641 ccgaggaccg gtgcgccgat cccgacctgc acgctggcgc cggtcctcct gcggagcacg
    14701 gcggtgatgt cctcggcgag ggtgaccagt gcgggttcca ccgcgccgag cggcacaccc
    14761 ggcagcaccg cgtacacccg cgtgccgatc gcgccgacca gcgcggaccg ccggtaggcg
    14821 gtggcatgca ccgagacgac gttgagcatc tccgccttgt gcagctcacg tgcggagtgg
    14881 tcgggttcgg ccggcgcggt cacggcggcg acgacggcag gagtcgcggg atcgagaccg
    14941 aggtgcccgg cgaccagatc ggggctggac cgcccgtcca gcagtccgga cacgagttcc
    15001 tgctgggagc ggttgcccgg tgagcttccc gcccggtagc gcaacaggtg cgccgcggcg
    15061 accctggacg cgccgagcag ggcgctttcg gcgcgttcgg cgaacggctc acggccctgt
    15121 tgcacccaga tcatgccgag gtactgggcg cccgccctga tacccaccgc cagcctgcgc
    15181 cggataccga cctcggggtg ctcgtcgatg tgcaccacct cgccgtcacg cagccgctgg
    15241 tagacacccc actcacggag catcgccaga taggactccg gtccctccca accgaggatg
    15301 gagagcctgc gcagctcgtc gacctcgtcg tccgatcggg agtaggcgag gacccggttg
    15361 cccgcgtcct cgatgatgac gctgcccgcg gtgaggacgg cgacggtctg cgcgagagcg
    15421 aagagatcgc cggtcccacc ctccgatccg agtccggccg agagagcagc cgcgtcgagc
    15481 acctcgcgca ccagcgtctc caactgctcc caccgcaccc tgggacgcac ggcgagcagg
    15541 gcgatccctg cctcggacgc ggcggcacgc aactcgtgca ggccgccctg cgtctccgga
    15601 ccgacctggg cgtccacctt cacggcagcg gccacagcgc cacgacgggc agcagcgcgc
    15661 acgaagcgaa cggcctcccg cccgcgggca ccgatgatca gcaccagttc accggagtag
    15721 ctgcccagct cgtcgtccgg gtccagaatg gtgacatcgc gaacctgcgc gtccagccac
    15781 gcgttggcga cgtacagatc gaccagcggt tccccgatcg cgaccagcag accgcgcagc
    15841 gtcggcgcat cttcccgcgg cgaatcgggc accagaattc ctctgttcga tcgaacaatg
    15901 ccaaccgtgg cacgttagcg gatgaaacaa tcccctgcga gttcgacctg cttagcgtgt
    15961 tcaggacacg tacccggcga gaggcagctc gaatggacgc catcaccacc acacccgcgc
    16021 cccgcaacga gccggtgcgg gactacgcac ccggctccgc ggagcgggag agcctgtccg
    16081 cgaagctcac cgaactggcc gggcagcaca ccgagctgac gctgaccatc gatggtgagc
    16141 aacggcccgg tggcggcagg cagatcgatg tcgtgcagcc gcacagacac agccacgttc
    16201 tcggcaccat gggcaacgcg acccaggagg acgccaaggc agcggtcgag tcctcacttc
    16261 gagcggcgga cagctggcgc aggctgccct tcgacgagcg ggccgccgtg ctgctgcgcg
    16321 cagccgacct gctgtcggga ccgtggcggg acacgctgaa cgcggcgacg atgctcggcc
    16381 agtcgaagac agccatccag gccgagatcg actccgcctg cgagctcgcc gacttctggc
    16441 ggttcaacgt gcacttcgcc cggcagatcc agcaggagca gccggtcagc tcccccggta
    16501 tgtggaaccg gctggactac cgtccgctcg agggcttcgt ctacgccatc acgccgttca
    16561 acttcaccgc catcgcgggc aacctcccca ccgcccccgc attgatgggc aacacggtcg
    16621 tctggaagcc ctcgcctaca cagggcctcg ccgcgcacct gaccatgcgg ctgctcgagg
    16681 aggccggact gccacccggc gtcatcaacc tggtcaccgg tgacggtctc gacgtctccg
    16741 aggtcgccct gaccgacccg gcgctggccg gggtgcactt caccggttcg tcgcggacct
    16801 tccagcatct gtggtcgacc gtcggcgcca acatctccgg ctaccgcacc tatccgcgcc
    16861 ttgtcggcga gacgggcggc aaggacttcg tgctggccca ccagtccgcc gatgtcgacg
    16921 tgctgcgcac ggcgctcgta cggggtgcgt tcgagttcca ggggcagaag tgctccgccg
    16981 cgtcgcgggc gttcgtgccg cgctcggtgt ggaaccgcat gcgtgacgac ctggtgtccg
    17041 aagtggaatc cctcgcggtc ggtgacgtca ccgacttccg caacttcatg ggcgcggtga
    17101 tcgaccgtcg cagcttcgac aagctcgccg ccgcacaacg cctggcccac gaggagtcca
    17161 ctctggacgt catcgccggt ggcacggccg acgactcgga gggtttcttc gtccggccca
    17221 cggtcgtggt cggcaccgat ccgacgcacg aggtgttcaa caccgagtac ttcggtccct
    17281 tcctcgccgt gcacgtgtac tccgacggtg acttcgacaa ggtgctgcag caggtggacc
    17341 agggtgcggc ctacgggctc accggtgccg tcatcgcaca ggaccgcgcg gccatcgcgc
    17401 gggcgagcga ggctttgcgg ttcgccgcgg gcaacttcta cgtcaacgac aagcccaccg
    17461 gggctgtcgt cggacagcag ccgttcggtg gcgcacgggc ttccggcacc aacgacaagg
    17521 cggggtccat ctacaacctg ctgcgctgga tcagcccgcg cacaatcaag gagaccttcg
    17581 tcccgccggt gaactccggc tacccacacc agggagagtg agatgttgcg ttcggctctg
    17641 ctcgcggcgg cgaagtcccc ggcctgccgc tccctggtcg agaacgcccc gccggtgcgc
    17701 ccgatcgtcg accgcttcgt cgcgggcggc gggctggacg acgcggtgcg cgcggcgaag
    17761 gagctcagca ccgaccggct ggtctcgctc gaccacctcg gtgaggacac caccgaccgc
    17821 gagcaggccg gcgcgaccgt gtccgcctac caggcactcc tccgcgcgct cggcgagcac
    17881 ggactcgccg agcgcgcgga ggtgtcggtg aaactctccg ccgtgggcca ggcccttccg
    17941 gtggacggcg agaagatcgc gctggacaac gtccggcaga tctgcgcgac cgcggccgcc
    18001 gttggcacca tggtcacggt tgacatggag gaccacacca ccaccgactc gaccctgtcg
    18061 atcgtgcgcg acctgcgcgt ggactttccc tcgacgggcg ccgtgctgca ggcctacctg
    18121 cggcgcaccg agtccgactg cgccgagctg gtcggacccg gttcgcggat ccggctctgc
    18181 aagggcgcat acgacgaacc cgagtccgtg gcgttccggg acaagacgga ggtggacgcg
    18241 tcctacgtgc gctgtctgcg gacgctgatg gcagggcagg gctatccgat ggtcgccacc
    18301 cacgatcccc ggctcatcgc gatcgccgag cacctcgcgg gcaaggccgg gcgcgagcac
    18361 gcggacttcg agttccagat gctctacggg atccggcccg aagcacagga actgctggcc
    18421 gcacgcgggc accggatgcg ggtgtacgtg ccgtacggcg ccgagtggta cccgtacttc
    18481 atgcgccgtc tcggtgagcg gccggcgaac atcgcgttct tcctgcgctc actgctgacc
    18541 aagggttagt gcctacggcc gttttccgcg tcagccggta ctgaccttgt cgcgggcctt
    18601 ctcgctgccc acgctgctct gccgggagca gtgcgcacag cagaagaagt gcccgtccac
    18661 ctcgactccg tgaccgatca cccggcaccg gcagtgctca cagatggggg ccagctgatg
    18721 gatcgcgcac tcgaacgagt cgaaggtgtg cttcgcgccg tcgcgggtgt ggatctcgaa
    18781 cgactggtcg taggtgtttc cgcagacttc gcagacgtcc atggtgatcc tttccgtcgt
    18841 tgcaccatgc tcggatagga atgaccgcat acgtccggct cgaaaccccg ggcgacgagg
    18901 aggccacgat gaccgctccc gacgtcgacc agctcaccgt ctacggcgcg ggctggtgcc
    18961 cggatgtccg gcgcagcagg gcactgctgg accgcgaggg ggtggcatac agctacgtcg
    19021 acgtcgagag cgatgaagcc gccgcggaag cggtgcggcg cctgcagggt ggcccgcgac
    19081 ggattccgac cgtcgtctgg cccgacggca cccacctggt ggagccgtcc gacgcggatc
    19141 tctccgcggc gctgcggcgc tgacgcggtc gggactcagc ggccggtgaa ctcggcctgc
    19201 ctgcgctcga cgaagctgcg cacgccctcc tcggcgtccg cgctgccgac gatgccgggc
    19261 agcagccccc gcaggtgctc agcggcctcg tgttcggagc cggaccgcag cgcgacccgt
    19321 gcgttggcca gggtgccctg gacgccgagc ggcgcctgcg cggcgatcaa cgccgcgagt
    19381 tccttcgccc gttcgagctg ggtgccggct ggaaccactt cctgcaccag gccgatccgg
    19441 tgggcctccg ccgcgccgaa ctcctcccct gtgagcagga accgcatggc gtttccccag
    19501 ccgagctgcg caggcgcacg tagtgtcgcg ccgccgaacg ggatgatgcc gcgaccgatc
    19561 tccaactgcc ggaaccgcac gtcgtcggcc gccaccacga tgtcgctggc gagcgcgagc
    19621 tcgatcgaga gggtgaaggc aattccctgc accgcgagca cgacgggttt gccgaccggc
    19681 tccttccaga gtccgaacgg gtcgtgcttg ccgtcgccgg acagcgcacc gggcccgtgc
    19741 tcccgaacgg cggggaagac gtcggtcagg tcgaggcccg cactgaagtg ctcgccgtgg
    19801 ccgtggacga cgccgacacg cagctcgtcg tcctcggcga gccggtcgta ggcggcactg
    19861 agctcggaga tcgtccgcag gtcccaggcg ttgcgcttgg cggcccggtc gaccccgatg
    19921 agcagtacat ggccgtctcg ctcgacggtg acccgatggg acatggcgct cctcctgttg
    19981 tccggacgca ggcgacctac tcgccggtaa ctaccggcgc caccctagcg gttcggcgtg
    20041 aggacgacct tgccggttgt cgccctgccc tccagtgcgg cgtgtgcgga agcggcttcg
    20101 gcgagcggga agggctcgtg cacaacaggc gacaagcgcc cctgcgcgag tgcggcgagg
    20161 gattcggtct ccagaccgcg aagtccgccg ggacggcgca gcagccgagg gccgacggcg
    20221 acggctgcgg ttagtccgcg cgagtagaga atctcggtgg tgatccggat gggctcgccc
    20281 gacgaccagc cgaacgtgat caccctgccg ccgatgccca gcatttcgag cgcggtctgc
    20341 ccaacggtgc cgccgacgcc gtcgagtacc acgctgggtt cacgtccgtc cagtgtggac
    20401 cgaaccgtcg ccgaccaatc ctcgccggag tagtccaccg ccgcatcagc tccgagtgaa
    20461 cggatcagtt ccaccttgtc ctgcccgcgc gcgaggccga tcaccatcgc accgacccgc
    20521 cgcgcctcct gcaccagcag ggtgccgatg ccgccggccg cggccggaac cagcacgacg
    20581 tcgtccgccg agagcgcggc gacgtgcagg atgcccacgg cggtgcggcc ggtaccgatc
    20641 atggccaccg ccgcggcgaa gtcgacctcg gcggacagtt cgtgcagcga ggaggccgcg
    20701 accaccgcga gttcggcgta accaccgctg gctggtccga ggtgcgcgac gacccgctta
    20761 ccgagccagt acccgtccac ccccgcgccc agttcgtcca ccactccggc cacctccctg
    20821 ccgggagtca tcggcagttc gggcaacggg aacggaccac cgttcgtgcc cgagcgaatg
    20881 gtggtgtcga gcaggtgtac acccgccacg gcgaccctga tccgcacctg cccttcggcg
    20941 ggcgcggggt cctgcacctc ttcctggcgg agcctgtcgg ctggaccgaa ctcgtgctgc
    21001 cgaatcgcgc gcattcacgt ctccacaact tctggccacg gctgtcccgc tggcgccgaa
    21061 gccaaagcta tgacttcgac attggttgag gtcaagacga atgctgaaac tcacagtcag
    21121 tgacatcacc cacgacaaag agaagtgtta gcaggtcagg gtgtcgcgat tgcgtcagtc
    21181 acagatgtcg atgtttaccc cgagtgacag gtagcgtggc ggagccttgg cgagcaccag
    21241 ggctctcgat catctcgtcc gccgggcccg caccactgag cgcgcatccc ggctccctgt
    21301 gaaaggacct ctcttgcggc gaaatctgcc gccgatgctt cgtgcgctcg gaaatcacaa
    21361 ctaccggctc tgggccacgg ctgacctcat ctcggtcacc ggatcctgga tgcaggtact
    21421 cggcctgaac tgggtggtga tggatcggac cgggtccgcc acctcggtcg gaatatccgt
    21481 gttgttgagc accctgccgt cgctgcttct cggcccatgg gcgggcgcgc tcgccgaccg
    21541 gttcaaaccc cagcggatca tcgtgctggg cgagtcgtta cacctgatca tcgcgctact
    21601 cctcgcgctg atggtcttca ctcacgtgcc gttgaccgcc atctacgcac tcaccgtggt
    21661 gtccgggctc atcggcacct tcgaggggcc cgccctgggc cggttcgcgg gccaggtggt
    21721 gccgcgtcag gaccttggca acgcactcgc gctgaactcg atcatcagct cgtccggccg
    21781 ggtgctgggc atgagcctgg cgggtgtgct ggccgccgtg atgggggccg ccctgctgtt
    21841 cgtgttcaac gccgtgacgt tcatcgcggt gatcgtcacg atcctggtga tgcgcaagga
    21901 agaactgcac gaactggcgg tgagcaccgc ggaacgcgcg ggggtgcggg cgggcctcac
    21961 gtatctgcgc agacagcgcg tgctggtgtt gctgttcgcc ctcggcttcg tcctgtccag
    22021 cctgggccgg aactatcagg tgaccatggc cgcgatgacc cagggaccgc tgggcacggg
    22081 tgccgccggt tacggaatgc tgtcgtcgat cttcgccgtc ggcaccgtgg tcggcgggct
    22141 catcgcggct cgtgcgcgtg agctcaccat ccccctcctg ctcggcgcgg ccgccgtcac
    22201 cagcgtgctg caggccgcca gtgggttgat tcccgggatg ctcgggttcg ccgcgctgat
    22261 cctgccgatc gcggcaggag ctgtgctgat cgacacgacg aagaccacgc tgttgcagtt
    22321 gggctgcgcc gacgacatgc gcgggcgggt gctcgccgtc gaaggtgcga tcgcggcggc
    22381 agctggtgcg gcgggcgctc cgctgctggg ctggttgtgc gaccggctcg gaccggaacc
    22441 ggctctgctg atggcgggtc tcgccacact cgtcgccacc gggatcgccg cgaccgctct
    22501 gcgcaagcca cgccgtgccg aggctgaggc tgaggctgcg gccgagacgc ccgtgtccga
    22561 cacgcccgcg cccgcgctgg
//
