LOCUS       NZ_FOET01000002        24436 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Streptomyces radiopugnans strain CGMCC 4.3519, whole genome shotgun
            sequence.
ACCESSION   NZ_FOET01000002
VERSION     NZ_FOET01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces radiopugnans
  ORGANISM  Streptomyces radiopugnans
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900110735.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:56:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,515
            CDSs (total)                      :: 5,440
            Genes (coding)                    :: 5,315
            CDSs (with protein)               :: 5,315
            Genes (RNA)                       :: 75
            rRNAs                             :: 4, 4, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 4, 5 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 41 of 125
            Pseudo Genes (incomplete)         :: 106 of 125
            Pseudo Genes (internal stop)      :: 6 of 125
            Pseudo Genes (multiple problems)  :: 26 of 125
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:58:30
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 127424
            Orig. end                         :: 151860
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOET01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24436
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24436
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24436
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14436](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14436)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            303..1232
                     /locus_tag="BMY40_RS05455"
                     /old_locus_tag="SAMN05216481_102127"
     CDS             303..1232
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088407.1"
                     /locus_tag="BMY40_RS05455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102127"
                     /product="transketolase"
                     /protein_id="WP_093656042.1"
                     /transl_table=11
                     /translation="MDTMRERFASVVSRLLDEDPRLAVVLAEIGADGFRRAAGRHPDRV
                     VNVGIREQLLVGVGGGLALTGMRPVLHTFASFLVERPFEQLKLDFGHQGTGGVLVSAGG
                     SYDWPAGGFTHMAPGDVALLDTLDGWTVHVPGHPDEAETLLRHACAGGDGRGDDRVYVR
                     LSAQTNARPLPVTGEGFLTVRRGGPGAPAVVAVGPLLGGVLDAVRGLDATVLYAATVRP
                     FDAAALRAAVVGSGAPEVVLVEPYLAGTSTAAAAEALADVPHRILGLGTARAELRRYGT
                     AAEHLAAHGLDPRSLRERITGFTAGAAV"
     gene            complement(1329..2249)
                     /locus_tag="BMY40_RS05460"
                     /old_locus_tag="SAMN05216481_102128"
     CDS             complement(1329..2249)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (33-176). E-value:
                     4.7e-14. Score: 44.5. Matches aSDomain:
                     nrpspksdomains_BMY40_RS05460_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019356254.1"
                     /locus_tag="BMY40_RS05460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102128"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_245769880.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-10, bitscore: 36.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.7e-11, bitscore:
                     40.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRADTTPAQDGLPVATYTWLPAGATPRALVQIAHGAAEHALRY
                     DRFARFLAGHGYAVVASDHRGHGATAEHTGGYGVVGESGWRAVVEDLKAVGDRLRAELP
                     GVPHVLLGHSMGSQLARDFAQEHGGGLAGLILSGTFRSLPGAEPQGAVERLREEIDRGG
                     RAAPSDFVPALFGSFNDPYEHRTGFEWLSRDEAEVDRYVADERCGFPFSAGLALDWVLG
                     VRKTNDPRQLDRVPRDLPVHVAVGDRDPCHQGMTLVYELLEDFRYLGLRDLTWRAYEGA
                     RHEILNETNRDEVQADLLAWLDDRV"
     aSDomain        complement(1722..2150)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BMY40_RS05460_Abhydrolase_1.1"
                     /evalue="4.70E-14"
                     /label="BMY40_RS05460_Abhydrolase_1.1"
                     /locus_tag="BMY40_RS05460"
                     /protein_end="176"
                     /protein_start="33"
                     /score="44.5"
                     /tool="antismash"
                     /translation="IAHGAAEHALRYDRFARFLAGHGYAVVASDHRGHGATAEHTGGYG
                     VVGESGWRAVVEDLKAVGDRLRAELPGVPHVLLGHSMGSQLARDFAQEHGGGLAGLILS
                     GTFRSLPGAEPQGAVERLREEIDRGGRAAPSDFVPALFG"
     CDS_motif       complement(1875..1931)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BMY40_RS05460_0001"
                     /evalue="1.50E-03"
                     /label="NRPS-te1"
                     /locus_tag="BMY40_RS05460"
                     /protein_end="125"
                     /protein_start="106"
                     /score="11.2"
                     /tool="antismash"
                     /translation="PHVLLGHSMGSQLARDFAQ"
     misc_feature    complement(2231..2248)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    complement(2373..2388)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            2661..4010
                     /locus_tag="BMY40_RS05465"
                     /old_locus_tag="SAMN05216481_102129"
     CDS             2661..4010
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088404.1"
                     /locus_tag="BMY40_RS05465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102129"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_093656044.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2e-31, bitscore:
                     104.0, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.3e-22, bitscore:
                     73.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.8e-30, bitscore:
                     100.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGYFADQRHKDLRLQVREFAEREVRPRIAEMEASRAVSHELSRL
                     IARQGWIGVTVPREYGGMGAGHLAKTIVIEELARVSGAMGAMVQASQLGVAKILHFGGE
                     EQKKQWLPAVASGDCLPTIAVTEPESGGHVLGMTSSAVRDGDDYVLNGRKVFVGNSHVG
                     DLHGVVVRTGPGSKGLSAFLVESDRPGFSLAPQKPSMGLHGFSFGELIFDNCRVPAANR
                     LGEEGDGLSVAYSSSVLYGRANLTAVSLGIHQAVLEETTRFCAERQRYGAPLGELGSIK
                     LKLGQMQSRLMTARLAAYHAVHLLDRGVPCDAELMNAKLVNVEYALDSAREAMEIHAAA
                     GLFTDRPVERYLRDAHHIFAPAGTSDIQRLRLGEVAMGTAKGQWSERLSDLVRTDPDGP
                     GEFAAHADLAAGIPPQTAETPETAPELFPEAAPQEPARRAGLLETLLNRR"
     gene            complement(4116..4691)
                     /locus_tag="BMY40_RS05470"
                     /old_locus_tag="SAMN05216481_102130"
     CDS             complement(4116..4691)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986115.1"
                     /locus_tag="BMY40_RS05470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102130"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_093656046.1"
                     /transl_table=11
                     /translation="MSPTSYDPTSHLLLTPQDSEAPARVTRLRELGIGDAPIPEFDDFA
                     RRLAQTTGAPYAMVNFIDEHRQYFAGLYAPGSDRAVELGPAQASSPQVGRVMARDHGYC
                     PHVVVRRKALVLEDVCDYPRFAGNPVVDEIGIRSYLGAPLIDRTGTALGTVCVVAQEPR
                     PWGRQGLETIKSMAAELVDEIHRREQGA"
     gene            complement(4672..5262)
                     /locus_tag="BMY40_RS05475"
                     /old_locus_tag="SAMN05216481_102131"
     CDS             complement(4672..5262)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152746.1"
                     /locus_tag="BMY40_RS05475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102131"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_093656048.1"
                     /transl_table=11
                     /translation="MDSVNDSDPFPTALKILIAGGFGVGKTTFVGAVSEIEPLSTEELL
                     TQVSAATDSLEGVEDKTTTTVAMDFGRITLSARHVLYLFGTPGQERFWFMWDELSSGAL
                     GAVVLADTRRLDQCFAAVDYFERRGMGFIVAVNEFDGAHRYHPDEVRVALDLKPEVPVV
                     MCDARHASSGTQVLVSLVQHLIDSRSGHVPHVV"
     gene            complement(5240..5614)
                     /locus_tag="BMY40_RS05480"
                     /old_locus_tag="SAMN05216481_102132"
     CDS             complement(5240..5614)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952099.1"
                     /locus_tag="BMY40_RS05480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102132"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_093656050.1"
                     /transl_table=11
                     /translation="MPEPEENLWLDDAAGRLVRPYTVSNGRTRPTADFNLLTMVRSTGT
                     KPQSYLGPDHAQVLSLCDGPMTVAEIAAHVRLPAVVTKVLLSDLVDCGAVTTRAPMQMG
                     ADPTDRELLEAVLHGLRKRL"
     gene            complement(5618..6034)
                     /locus_tag="BMY40_RS05485"
                     /old_locus_tag="SAMN05216481_102133"
     CDS             complement(5618..6034)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236638.1"
                     /locus_tag="BMY40_RS05485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102133"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_093656052.1"
                     /transl_table=11
                     /translation="MVSDAPIGQTTDLSWLLTGLVQRVPSTRSALLLSSDGLVKAAHGL
                     DTDTADHLAALASGLYSLARSAGIRFGSGGEVRQVVVELDTALLFVSTAGSGACLAVLA
                     ESEADAAVLGYEMAMLVKSVRPYLATPARQPAGH"
     gene            complement(6075..7985)
                     /locus_tag="BMY40_RS05490"
                     /old_locus_tag="SAMN05216481_102134"
     CDS             complement(6075..7985)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088398.1"
                     /locus_tag="BMY40_RS05490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102134"
                     /product="ATP-binding protein"
                     /protein_id="WP_245769881.1"
                     /transl_table=11
                     /translation="MSVASPPSPPSVPSPPGRPAPPAYDGVPSAASAPGRRRRKRGAGA
                     AHDTGHRRGPARDTAADTALRHRMIRLAVLPAALVAVIAAAVVAYVLRALDGVREGVSA
                     GPDGATVWGVLGGALLLGCAVVVGAALSASSEARSTAERHARLRQGAAHSQGELQSMLR
                     RLEKGEWLRPPVHGPLPEPEGDSLGLVVHDVSQAQRAAELALVQAVALVRSNASGSEEK
                     VEVFVNLARRLQSLVHREIELLDELENEVEDPDLLKGLFHVDHLATRIRRHAENLAVLG
                     GAVSRRQWSRPVTLTEVLRSAIAEVEQYSRVKLVPPIEGTLRGHAVADVIHLLAELVEN
                     ATVFSAPNTQVLLRAQRVTAGLAVEVEDRGLGMTAAEQHRMNGLLADPDGIDVAELLQD
                     GRIGLFVVSSLARRHGITVQLQTNIYGGTQAVLVVPDAVLGDEGGEAQRRAAVEADAGG
                     HRPLPPETPRQETPRQETSRQDAPPQQSYAQQSYGQQDHGQHAYGQQMYEQETARPLPH
                     AAPAAPSEYGPPQPRPHYQSSAAEAAAPAAQSVSASRAVPAPPFPEGPGGPEGAAGGDR
                     PQLPRRRRQEHLVPELRQSPRAPGASDEPEAEHTPGLMAAFRRGASLAEGTDDNTPSQP
                     S"
     misc_feature    8108..8123
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.05"
                     /tool="antismash"
     misc_feature    complement(8218..8233)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.06"
                     /tool="antismash"
     misc_feature    8219..8233
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            complement(8247..8888)
                     /locus_tag="BMY40_RS05495"
                     /old_locus_tag="SAMN05216481_102135"
     CDS             complement(8247..8888)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010470562.1"
                     /locus_tag="BMY40_RS05495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102135"
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_093656740.1"
                     /transl_table=11
                     /translation="MDDALFRLPAVEVAPGAVHLPGHLDGAAQRELLDACRAWARPPAG
                     LRTVRMPRGGEMSVRQVGLGWHWYPYGYARTAVDGDEAPVKPFPAWLGRWARRAVEEAY
                     GDGSCTVPYEIALVNFYGGKARMGMHRDSDERSRDPVVSFSLGDTCVFRFGNPDGRGRP
                     WTDVELRSGDAFVFGGPSRLAYHGVPRVHPGTAPLGTGLRGRVNVTVRAR"
     gene            9125..9919
                     /locus_tag="BMY40_RS05500"
                     /old_locus_tag="SAMN05216481_102136"
     CDS             9125..9919
                     /EC_number="3.1.3.48"
                     /GO_function="GO:0004721 - phosphoprotein phosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004725 - protein tyrosine phosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069689.1"
                     /locus_tag="BMY40_RS05500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102136"
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_093656055.1"
                     /transl_table=11
                     /translation="MTSETVEPVLAGVRNFRDVGGLPTTDGRRVRQGVLYRSGHLAHAT
                     EEDAAFLARLGLHTVFDFRNSADQALEGPDVELPGVRNVNIPLSDPAEGAEFWTMVREG
                     DLALLRSLLGEGQAEARMVASYRMMVRQRTSEHGRLLRELADESVPALMHCAAGKDRAG
                     LSIAVTLLALDVERDAIEADYLESNAPHRRYRIHRSPDAGGGMSPEVRELIAPLFEVRP
                     AYLHAAFDTITETWGGVESYLSEGLGLTPGLRERLRDRLLEP"
     gene            complement(10001..11059)
                     /locus_tag="BMY40_RS05505"
                     /old_locus_tag="SAMN05216481_102137"
     CDS             complement(10001..11059)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016574768.1"
                     /locus_tag="BMY40_RS05505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102137"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_093656742.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.5e-58, bitscore:
                     192.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTAVDTASVIELLERGRTLATPMLRAAVARLAPPMDSVAAYHF
                     GWIDAQGNPARGDGGKAVRPALALLSAEAAGAEPATGVPGAVAVELVHNFSLLHDDLMD
                     GDEQRRHRDTVWKVHGPAQAILVGDALFALAGEVLLELGTAEAARATRRLTLATRKLID
                     GQAQDISYEHREKVTVAECLEMEGNKTGALLACATSIGAVLGGADEATADALEAYGHHL
                     GLAFQAVDDLLGIWGDPSATGKLPWSDLRQRKKSLPVVAALAGGGPAAERLGELLAADA
                     AKSQREFEDFSEEEFATRAGLIEEAGGREWTSQEARRRHATALAALDGVDMPDRVREQF
                     AALADFVVVREG"
     gene            complement(11112..12539)
                     /gene="hpnE"
                     /locus_tag="BMY40_RS05510"
                     /old_locus_tag="SAMN05216481_102138"
     CDS             complement(11112..12539)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983091.1"
                     /locus_tag="BMY40_RS05510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102138"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_093656057.1"
                     /transl_table=11
                     /translation="MSGAPDPRAVVVGGGLAGTAAALRLADAGVATTLVESRPRLGGLA
                     FSFRRSGAAGELTVDNGHHVHLRCCTAYRWFLERIGASALAPLQPRLDIPVHDAARGRT
                     GRLRRAALPAPLHLGPSLARYPHLSPAERLRVGRAALALGRLGRVDPSDPALDAQDFGS
                     WLRRHGQSPRAVRALWDLVGVATLNARAPDVSLGLAAMVLTTGLLSEPGAADIGWSRVP
                     LGHLHDTLAAAVLEKAGVRVVRQGRARELTREPDGAWRVAVDTGARRTGRTLRAGTVVL
                     AVPQREAHRLLPEGALEEPERLLRIGDAPILNVHVVYDRKVLHRPFLAALGTPVQWVFD
                     RTAASGLRSAPGGAASQYVAVSQSAAQDEIDLPVAALRDRYLPELARLLPAAREAKVRD
                     FFVTRERTATFAPVPGVGRLRPAARTGAPGLWLAGAWTATGWPATMEGAVRSGLTAARE
                     ALAALGRPHDDVFQEAA"
     gene            complement(12536..13507)
                     /gene="hpnD"
                     /locus_tag="BMY40_RS05515"
                     /old_locus_tag="SAMN05216481_102139"
     CDS             complement(12536..13507)
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072792.1"
                     /locus_tag="BMY40_RS05515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102139"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_093656059.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.8e-57, bitscore:
                     188.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.9e-69,
                     bitscore: 228.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERRTANAERAARQAPPSPQVFAAYRYCEAVTGRQARNFAYGIRL
                     LPTAQRRAMSALYAFSRRVDDIGDGPLETEVKRARLEETRDLLDLVRAGKVPDDATDPV
                     AVALADAADRFPIPLGGLDELIDGVLMDVRGRAYETWDELKEYCRCVAGAIGRLSLGVF
                     GTVPGAPGADRAPHYADTLGLALQLTNILRDVREDATEGRTYLPREDLAAFGCDTSLDR
                     HAPPAGGDFAGLVRFEVGRARALFAEGLRLLPLLDRRSAACVAAMAGIYHRLLARIARD
                     PHAVLRGRVSLPAREKAYVALRGLSGLDARLAARTAPGESAT"
     gene            complement(13513..14436)
                     /gene="hpnC"
                     /locus_tag="BMY40_RS05520"
                     /old_locus_tag="SAMN05216481_102140"
     CDS             complement(13513..14436)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513262.1"
                     /locus_tag="BMY40_RS05520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102140"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_245769882.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.5e-34, bitscore:
                     114.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 9.2e-37,
                     bitscore: 121.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPARDARSRAVLDKAARENFPVAPRFLPRAWRDDLMAVYGCVRL
                     LDDIGDGDLPPGGADAALLGVDPGRAGDRGALLDAFETDLHRVFRTARDPGAEGRDVPR
                     HPLLYALVPTVRRHALTPEPFLALVEANRLDQKVRRYGTWEELLGYCELSANPVGRLVL
                     AVTGTTTPERVRRSDAVCTALQIIEHLQDVAEDLALRDRVYLPAEDLERFRVTEADLAA
                     PTANASVRALVAWEARRAHELLNEGVPLVASVPGIPKILIAGFTGGGRAALRALSSARY
                     DVLGGAPRPTPAGVLRETAAVLGRAR"
     gene            complement(14642..15364)
                     /locus_tag="BMY40_RS05525"
                     /old_locus_tag="SAMN05216481_102141"
     CDS             complement(14642..15364)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018838705.1"
                     /locus_tag="BMY40_RS05525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102141"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_093656745.1"
                     /transl_table=11
                     /translation="MRTEGTGKSGYHHGDLRNALIEAATDLARDGGPEAVVLRAAARRV
                     GVSPTAAYRHFTGQGDLLMAVKEQGQRGLAETMERSAGARGGSPSAGEAAEERVRALGA
                     GYIEFALAEPGLFRAAFCRTPEAPDGGHGPGPEEDPSRWMYRSFRLLAEALDGLVATGR
                     MPAGRRPGAEITAWAAVHGLAVLLLDGPLGRLAPEQRDAFTASALTTVIRGFTAPERPS
                     ATRPAGPAAKDAPEHDVS"
     gene            15474..17690
                     /locus_tag="BMY40_RS05530"
                     /old_locus_tag="SAMN05216481_102142"
     CDS             15474..17690
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135437.1"
                     /locus_tag="BMY40_RS05530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102142"
                     /product="MMPL family transporter"
                     /protein_id="WP_093656061.1"
                     /transl_table=11
                     /translation="MLSWIADLVLRRPRTVLVAALVSVLAMAAVGIGAFGKLQSGGFDD
                     PDAPSSRATALIDEKFGGETNLVLLVRADGGGRLDSPAAERAGREIADGLKDEPGVSGV
                     VSYWDTGGSALTSRDGDQALILAHIEGDDTERTDRAGELSEKWSGDRGAVTVHTGGQAA
                     VASDITSQISKDLAIAEAIAVPITLILLVIAFGSVVAALLPLAIGLIAVMGTFAELYVL
                     GSITDVSIFSINLTTALGLGLGIDYGLLLVSRFRERLTEGDDVPDALRTTVATAGRTIA
                     FSAATVVAALAALLLFPPFFLRSFAYAGIGVVAIAAVGALVVVPALLAVLGHRVNSGRL
                     PWAESVRRPDAPVWGRLASVVMRRPALTALPVLAVLLLAASPLLGASFGNPDERVLPDS
                     APSRQVATAVDEDFGRDDTSAVQIVTTGPVDAAGLDAYATAVSRLDGVTRVQASSGTYQ
                     DGEAAPPGPVNAALGRDDAQRLTVATEPESGSGAAEDLVHDIRAVPAPDGVEALVGGPD
                     ARLVDTKAAIGDRLPAAIAWVALTTFALLFLFTGSVVQPLRALVLNTISLTAAIGAMVW
                     IFQEGNLSSVLGFTPMPMNTSMTVLLFCIVFGLSMDYEVFVTSRIKELHDAGEDTGTAV
                     THGLSRTGRIVTMAAGLLAVSLFAFTTSEISFMQMFGLGSGLAILIDAVAVRGVLVPAA
                     MRLLGRGAWYAPKALRRLHGRVGLSEAAAPPPAPAEPRREPAGI"
     gene            complement(17781..18614)
                     /locus_tag="BMY40_RS05535"
                     /old_locus_tag="SAMN05216481_102143"
     CDS             complement(17781..18614)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019432678.1"
                     /locus_tag="BMY40_RS05535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102143"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_093656063.1"
                     /transl_table=11
                     /translation="MAVAEKSAAAASAHKDEGAAEAAPVERRPTVIADDLHIVYRVNGG
                     GRGRGSATAALSRILRRKAPAGMREVHAVKGVSFTAYRGEAIGLIGSNGSGKSTLLRAI
                     AGLLPAERGRVYTDGQPSLLGVNAALMNDLTGERNVILGGLAMGMSRAQILERYQDIVD
                     FSGINDKGDFISLPMRTYSSGMAARLRFSIAAAKDHDVLMIDEALATGDKKFQRRSEAR
                     IRELRQEAGTVFLVSHNNKSIRDTCDRVLWLESGELRMDGPTEEVMKAYEEFTRK"
     gene            complement(18601..19539)
                     /locus_tag="BMY40_RS05540"
                     /old_locus_tag="SAMN05216481_102144"
     CDS             complement(18601..19539)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958860.1"
                     /locus_tag="BMY40_RS05540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102144"
                     /product="ABC transporter permease"
                     /protein_id="WP_093656065.1"
                     /transl_table=11
                     /translation="MSDTTHGGAIATSEPPRSPDDGLSPAELAAKYGLTVSGARPSLTE
                     YVRQLWARRHFILAFSRAKLHAQYSQAKLGQVWQVLTPLLNAAVYYFIFGLLLGGRGGM
                     ENDEYIPFLVTGVFVFTFTQTSVMSGVRSISGNLGLVRALHFPRASLPVSFSLQQLQQL
                     LFSMIVLVVILVGLGHYPGPLWLLVVPALLLQFLFNTGLAMIMARLGSKTPDLAQLMPF
                     VLRTWMYASGVMFPLAYMLEKANAPGWLAGVLEANPAAVYMELMRYALIDGPHHQSLDG
                     YVWLLAAGWALVIGIGGFVYFWKAEERYGRG"
     gene            complement(19635..20507)
                     /locus_tag="BMY40_RS05545"
                     /old_locus_tag="SAMN05216481_102145"
     CDS             complement(19635..20507)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031159.1"
                     /locus_tag="BMY40_RS05545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102145"
                     /product="glycosyltransferase"
                     /protein_id="WP_093656747.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 9.4e-11,
                     bitscore: 36.9, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLGAVVLTMGNRPEELRALLDSVAKQDGDPVQVVVVGNGAPLPE
                     LPEGVRTVELPENLGIPGGRNVGIEAFGPGGSEVDALLFLDDDGLLPNTDTAELVRQAF
                     AADPELGIISFRIADPDTGATQRRHVPRLRASDPMRSSRVTTFLGGANAVRTAVFRQVG
                     GLPDEFFYAHEETDLAWRALDAGWMIDYRADMVLHHPTTLPSRHAVYHRMVARNRVWLA
                     RRNLPLPLIPLYLGVWLLLTLARRPSRPALRAWLGGFREGWTTPCGPRRPMKWRTVWRL
                     TRLGRPPVI"
     gene            complement(20568..21353)
                     /locus_tag="BMY40_RS05550"
                     /old_locus_tag="SAMN05216481_102146"
     CDS             complement(20568..21353)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962488.1"
                     /locus_tag="BMY40_RS05550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102146"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_093656067.1"
                     /transl_table=11
                     /translation="MSKPSVAELRPVVHPAGVKDRRSGEHWAGRLYMREISLRWTRHLV
                     NTRITPNQLTYLMVVAGVAAGAVLLVPGLTGAVLAALLIQFYLLLDCVDGEVARWRKQT
                     SITGVYLDRVGHYLAEAALLVGFGVRAADVFRTEGASANWLWAFLGTVAALGAILIKAE
                     TDLVDVARSRSGLPAVKDEAAVPRSSGLALARRAAAALKFHRLVGGVEASLVILLVAVA
                     DVLHGGLFFTRLGVAVLAAIAVLQTLLHLVSILASSRLR"
     gene            complement(21331..22392)
                     /locus_tag="BMY40_RS05555"
                     /old_locus_tag="SAMN05216481_102147"
     CDS             complement(21331..22392)
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413836.1"
                     /locus_tag="BMY40_RS05555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102147"
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_093656069.1"
                     /sec_met_domain="Fe-ADH (E-value: 4e-20, bitscore: 67.0,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTRLIPSPVVVDIRPGALDDLAGLLVDQRISASGKLAIAISG
                     GSGAALRERFAPALPGADWYEVGGGTLDDAIKLADAMKSGHYDAVVGMGGGKIIDCAKF
                     AAARIGLPLVAVATNLSHDGLCSPVATLDNDAGRGSYGVPNPIAIVIDLDVIREAPIRF
                     VRSGVGDVISNISAVADWELSHKVTGESIDGLAAAMARQAGEAVLRHPGGCGDDEFLTV
                     LAEGLVLTGISMSVAGDSRPASGACHEINHAFDLLYPKRAAAHGEQCGLGAAFAMHLRG
                     AEEQTALIVDVLRRHGLPVLPGEIGFNEDEFVRAVEYAPQTRPGRYTIIEHLDLSTDQI
                     RDAYADYVKAVSS"
     gene            complement(22380..23129)
                     /locus_tag="BMY40_RS05560"
                     /old_locus_tag="SAMN05216481_102148"
     CDS             complement(22380..23129)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640650.1"
                     /locus_tag="BMY40_RS05560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05216481_102148"
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_093656070.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.9e-12, bitscore:
                     41.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVDPAGEGTTTVLDLTLGN
                     FREVGLTDVAVVVGYRKEAVHERRAALEKKYGVKLHLVENDKAEEWNNAYSLWCARDVI
                     KEGVILANGDTVHPVSVEQTLLEARGKGQRIILALDTVKKLADEEMKVVTEPGRGVRRI
                     TKLMDPADATGEYIGVTLIEGDAAADLADALKATYERDPQLYYEDGYQEMVDRGLTIDT
                     AAIGDVRWVEIDNHDDLNKAREIACQY"
ORIGIN
        1 tcggggacgc cgagctggac gagggcagca accacgaggc gatcgacttc gcgggcgccg
       61 ccgggctcga ccgcctgcac gtcctggtga tcgacaactc ctccgcctcc caccccctgc
      121 ccggcggcgt cgcctcccgt ttcacggccg cgggctggtc ggcgctgacc gtcgacggcc
      181 gcgaccacga ggcgctgtac gcggcgtaca ccagccggca ccccgggcgc ccgcacgccg
      241 tggtcgcccg cgtcgaaccc aagcacgcct gaccggcacg gaaagcacga ggagatcccc
      301 atatggacac catgcgcgag cgcttcgcct ccgtcgtctc ccgcctgctg gacgaggatc
      361 cgcgcctggc ggtcgtcctc gccgagatcg gcgcggacgg cttccgccgg gccgccgggc
      421 gccacccgga ccgggtggtc aacgtcggca tccgcgagca gttgctggtg ggcgtgggcg
      481 gcgggctggc cctcaccggc atgcgcccgg tactgcacac cttcgcctcc ttcctggtgg
      541 aacgcccctt cgagcagctg aagctggact tcgggcacca ggggacgggc ggtgtgctgg
      601 tgagcgccgg aggctcctac gactggccgg ccggcggctt cacccacatg gcgcccggtg
      661 acgtggcgct gctggacacc ctggacggct ggaccgtcca cgtgcccggc caccccgacg
      721 aggccgagac gctgctgcgc cacgcctgcg cgggcgggga cgggcgcggg gacgaccggg
      781 tgtacgtccg gttgtcggcg cagaccaacg cacgccccct gccggtcacc ggcgagggct
      841 tcctcaccgt gcggcgcggc ggccccgggg ctccggcggt cgtcgcggtc ggcccgctgc
      901 tcggcggcgt cctcgacgcc gtacggggac tggacgcgac ggtcctgtac gccgccaccg
      961 tccgcccctt cgacgcggcc gccctgcgtg cggccgtcgt cggctccggc gcccccgagg
     1021 tcgtcctggt cgagccgtac ctggccggca cctccacggc ggcggccgcc gaggccctgg
     1081 ccgacgtccc gcaccggatc ctcgggctgg ggacggcacg ggccgagctg cgccgctacg
     1141 gcacggccgc cgagcacctg gcggcccacg gcctggaccc gcgctcgctg cgggagcgga
     1201 tcaccggctt cacggcgggc gccgcggtct gacgacgccc gccccgcgcg gcctgcccgt
     1261 ccgcggtggt cccgccggcc ccggcccccg cgcgccgtct cgcacgcgcc cttctcacac
     1321 gcgccttctc acacgcggtc gtccagccag gccagcaggt ccgcctggac ctcgtcgcgg
     1381 ttggtctcgt tgaggatctc gtgccgggcg ccctcgtagg cccgccaggt cagatcgcgc
     1441 agccccaggt agcggaagtc ctccaggagt tcgtacacca gcgtcatgcc ctggtggcag
     1501 gggtcccggt cgccgaccgc gacgtgcacc ggcaggtcgc gcggcacgcg gtcgagctgc
     1561 cgcgggtcgt tggtcttgcg cacccccagc acccagtcca gcgccaggcc ggcgctgaag
     1621 gggaagccgc accgctcgtc ggcgacgtac cggtcgacct ccgcctcgtc gcgggagagc
     1681 cactcgaatc cggtgcggtg ctcgtagggg tcgttgaagg agccgaagag ggcgggcacg
     1741 aagtccgagg gggcggcgcg gccgccgcgg tcgatctcct cccgcagccg ctccaccgcc
     1801 ccctgcggct ccgcgccggg cagcgagcgg aaggtccccg acaggatgag cccggccagc
     1861 ccgccaccgt gctcctgggc gaagtcgcgg gcgagctggg agcccatgct gtgcccgagc
     1921 aggacgtggg gcacaccggg cagctccgcg cgcagccggt cgccgaccgc cttcaggtcc
     1981 tccaccacgg cccgccagcc gctctccccc accacgccgt atccgccggt gtgttcggcg
     2041 gtggcgccgt ggccgcggtg gtcggaggcg acgaccgcgt agccgtgccc ggccaggaag
     2101 cgggcgaacc ggtcgtagcg cagggcgtgt tcggccgcac cgtgcgcaat ctgcaccagc
     2161 gcgcgggggg tcgcgccggc cgggagccag gtgtaggtgg cgacgggcag tccgtcctgg
     2221 gccggggtgg tatccgctcg cagggtcacg ttctctcgct cctcggtgtc ggcgggtcgg
     2281 gaggaccctt ccccaccaca cccccggccg aacagacccc agcccttagc atgacggggc
     2341 gtccgatcgc acgctgtcgg cgcgaacggt tctgtgacgt cggttacaca cgggggtcgt
     2401 gtaaccgggc tatgccactg ggtagtgctc ccgggtaatc cgctcagggc tcatcgtgtt
     2461 cagatcaatc aacacccccc gcgaaaggca ctctgcatga cccaatggca tattttcggc
     2521 catagtcatg gagtgatctt gaaatgatcc gcacgccgga gacgatgttg gtggtgtcgg
     2581 ccgaacgggg cgggaccacc gcagacgctc cacccccgcc tgacaggcaa gcgggggcgt
     2641 accgcagaag agggctcgtc atggatggtt acttcgccga ccagcggcac aaggacctgc
     2701 gtctgcaggt gagggagttc gcggaacggg aggtccggcc gcggatagcc gagatggagg
     2761 cgtcacgcgc ggtctcccac gagctgtccc ggctgatcgc ccgccagggg tggataggcg
     2821 tgaccgtccc ccgtgagtac ggcggaatgg gggcgggtca cctcgccaag acgatcgtca
     2881 tcgaggaact cgcgcgggtg agcggggcca tgggcgccat ggtccaggca tcgcagctcg
     2941 gcgtcgccaa gatcctccac ttcggcggcg aggagcagaa gaagcagtgg ctgcccgcgg
     3001 tcgcctccgg cgactgcctg ccgacgatcg ccgtcaccga gccggagtcc ggcggccacg
     3061 tcctcggcat gaccagcagc gccgtccggg acggcgacga ctacgtcctc aacggccgca
     3121 aggtcttcgt cggcaacagc cacgtcggcg atctgcacgg cgtagtggtg cgcaccgggc
     3181 ccggctccaa gggactgtcc gccttcctgg tggagtccga ccggcccggc ttctccctgg
     3241 ccccgcagaa gccctcgatg gggctgcacg gcttcagctt cggcgagctg atcttcgaca
     3301 actgccgcgt cccggcggcc aaccggctcg gcgaggaggg cgacggcctg tccgtggcct
     3361 actcctcgag cgtgctgtac ggacgcgcca acctcaccgc cgtgtccctc ggcatccacc
     3421 aggccgtcct ggaggagacg acgaggttct gcgccgagcg gcagcgctac ggcgcccctc
     3481 tgggcgaact gggctccatc aagctgaagc tggggcagat gcagtcccgg ctgatgacgg
     3541 cccggctggc cgcctaccac gcggtgcacc tgctggaccg cggcgtgccc tgtgacgcgg
     3601 agctgatgaa cgccaagctg gtgaacgtgg agtacgccct ggactccgca cgcgaggcca
     3661 tggagatcca cgccgccgcg ggcctgttca ccgaccggcc cgtcgagcgc tatctgcgcg
     3721 acgcccatca catcttcgcc cccgccggga cctcggacat ccagcggctg aggctgggcg
     3781 aggtggcgat gggcaccgcg aagggccagt ggtcggagcg gctgtcggac ctggtgcgga
     3841 ccgaccccga cggccccggt gaattcgcgg cccacgcgga cctcgcggcc gggatacccc
     3901 cgcagaccgc ggagaccccg gagacggcac cggagctgtt ccccgaggcc gccccccagg
     3961 agcccgcgcg ccgcgcgggg ctgctggaga cgctgctcaa caggcgctga gcggcgagcg
     4021 cgggctcctg gggggcggcc gggcgccgag cagccgccgg accgccgggc ggatccgttc
     4081 cgtgggtgcc ggagcactca cggaacggac gccgctcagg cgccctgctc ccgccggtgg
     4141 atctcgtcca ccagctcggc ggccatcgac ttgatggtct ccagtccctg gcggccccac
     4201 gggcggggct cctgcgccac cacgcagacc gtcccgagcg ccgtgccggt gcggtcgatg
     4261 agcggagcgc ccaggtagga gcggatgccg atctcgtcca cgaccgggtt cccggcgaag
     4321 cgggggtagt cgcagacgtc ctccaggacc agggccttgc gccgcaccac gacgtgcggg
     4381 cagtagccgt ggtcgcgggc catgacccgg ccgacctgcg gggaggaggc ctgcgccggc
     4441 cccagctcca cggcccggtc ggagcccggt gcgtacagac ccgcgaagta ctggcggtgc
     4501 tcgtctatga agttgaccat cgcgtagggg gcgccggtgg tctgcgccag cctgcgggcg
     4561 aagtcgtcga actccgggat gggggcgtcc ccgatgccca gctcgcgcaa ccgcgtcacc
     4621 cgcgccgggg cttcactgtc ctggggtgtg aggagcaggt ggctggtggg gtcatacgac
     4681 gtgggggaca tggccactcc ttgagtcgat caggtgctgg acaagggata cgaggacctg
     4741 cgtgccggaa ctggcgtgcc gcgcgtcgca catcaccacc ggcacctcgg gcttgaggtc
     4801 gagggcgacc cggacctcgt cggggtggta gcggtgggcg ccgtcgaact cgttgaccgc
     4861 gacgatgaac cccatgccgc gccgctcgaa gtagtccacg gccgcgaagc actggtccag
     4921 gcgccgggtg tcggcgagca ccacggcgcc gagcgcgccg ctggacaact cgtcccacat
     4981 gaaccagaag cgctcctgac cgggggtgcc gaacaggtag agcacatgcc tggcgctgag
     5041 ggtgatccgc ccgaagtcca tcgcgacggt ggtggtcgtc ttgtcctcca ccccctccag
     5101 gctgtccgtg gcggcgctga cctgggtgag cagctcctcc gtgctcaacg gctcgatctc
     5161 gctgacggct cccacgaagg tcgtcttgcc gaccccgaac ccgcccgcga tcaggatctt
     5221 cagggcggtc ggaaacggat cagagtcgtt tacggagtcc atgcagcacc gcctccagca
     5281 gttctcggtc ggtcgggtcc gcccccatct gcatgggggc ccgtgtggtc acggcgccgc
     5341 agtccaccag gtcggagagc agcaccttgg tcaccacggc gggcagccgc acgtgggcgg
     5401 cgatctcggc gacggtcatc ggcccgtcgc acaaactcag cacctgggcg tggtcgggtc
     5461 ccagatagct ctgcggcttg gtcccggtgg accgcaccat cgtcagcagg ttgaagtcgg
     5521 ccgtcggccg cgtccgtccg ttgctgacgg tgtacggccg gaccaggcgt ccggccgcgt
     5581 cgtccaacca caagttctcc tcgggttccg gcatccgtca gtgccccgcc ggctgccgcg
     5641 ccggtgtggc cagatacggg cggacgctct tgaccagcat cgccatctcg tatccgagta
     5701 cggccgcgtc cgcctcgctc tcggcgagga cggccaggca cgcgccggag cccgcggtcg
     5761 agacgaacag cagcgcggtg tcgagctcga cgaccacctg ccgcacctct cctccgctgc
     5821 cgaagcggat gccggcgctg cgggccagcg agtacaggcc cgaggccagc gccgccagat
     5881 ggtcggcggt gtcggtgtcc agtccgtggg cggccttcac caggccgtcg gaggacagca
     5941 gcagtgcgct gcgggtgctc gggacgcgct ggacgagacc ggtcagcagc caggacaggt
     6001 cggtcgtctg gccgatgggg gcatcgctca ccatgatcgc gttcttctcc ttggggtgag
     6061 agccgtgcgc gggactagct tggctggctg ggggtgttgt cgtcggttcc ctccgcgagg
     6121 ctggcgcccc ggcggaaggc ggccatcagg ccgggagtgt gctcggcctc gggctcgtcc
     6181 gacgcccccg gggcccgcgg agactggcgc agttcgggaa cgaggtgctc ctggcgacgg
     6241 cggcgcggga gctgcggacg gtcgccgccc gccgcgccct ccggcccgcc ggggccctcc
     6301 gggaacggcg gtgccggtac ggcccgggag gcggacacgg actgcgcggc gggggcggcg
     6361 gcctccgccg cggaggactg gtagtggggc cggggctggg gcggaccgta ctccgaaggc
     6421 gccgcggggg cggcgtgggg caggggccgg gccgtctcct gctcgtacat ctgctgccca
     6481 taggcgtgct gcccgtggtc ctgctgcccg taggactgct gtgcgtagga ctgctgaggg
     6541 ggcgcgtcct gacgggaggt ctcctggcgg ggggtctcct ggcggggggt ctcgggcggc
     6601 agcggccggt gcccgcccgc gtccgcctcc acggcggcac gccgctgcgc ctccccgccc
     6661 tcgtcgccca ggaccgcgtc cggtacgacg agcaccgcct gggtgccgcc gtagatgttg
     6721 gtctgcagct gcacggtgat gccgtgccgc cgggcgagcg aggagaccac gaagagcccg
     6781 atgcggccgt cctgcagcag ttcggcgacg tcgatcccgt cggggtcggc cagcagtccg
     6841 ttcatccggt gctgctcggc ggccgtcatg cccagcccgc ggtcctcgac ctcgacggcc
     6901 agacccgcgg tgacgcgctg ggcgcgcagc aggacctggg tgttgggggc ggagaacacc
     6961 gtggcgttct cgaccagttc ggcgagcagg tggatgacgt cggcgacggc gtggccgcgc
     7021 agggtgccct cgatcggcgg caccagcttg acccgggagt actgctcgac ctcggcgatg
     7081 gccgagcgca gcacctcggt cagggtgacc gggcggctcc actgccggcg ggagaccgcg
     7141 ccgccgagga cggcgaggtt ctccgcgtgc cgccggatgc gggtggccag gtggtcgacg
     7201 tggaagaggc ccttgagcag gtccgggtcc tcgacctcgt tctccagctc gtccagcagc
     7261 tcgatctcac ggtgcaccag ggactgcagc ctgcgggcga ggttgacgaa gacctcgacc
     7321 ttctcctcgc tgccgctggc gttgctgcgc accagcgcga ccgcctggac cagagccagt
     7381 tcggcggcgc gctgggcctg gctgacgtcg tggacgacga ggcccagcga gtcgccctcc
     7441 ggctcgggca gcggaccgtg cacgggcggc cgcagccact cgcccttctc cagccggcgg
     7501 agcatcgact ggagttcgcc ctggctgtgg gccgcgccct gccgcagccg ggcgtggcgc
     7561 tcggcggtgg aacgtgcctc ggaggaggcg gagagcgcgg cgccgaccac cacggcgcag
     7621 ccgagcagca gcgcgccgcc gagcacgccc cagacggtgg cgccgtcggg ccccgcggac
     7681 accccctccc gcacaccgtc gagcgcccgc agcacgtagg cgacgaccgc cgcggcgatg
     7741 accgcgacca gggccgcggg caggacggcg agacggatca tgcggtgccg cagcgcggtg
     7801 tcggcggcgg tgtcgcgggc ggggcccctg cggtgccccg tgtcgtgtgc cgcgcccgcg
     7861 ccccgcttcc tcctgcgcct tcccggtgcg gaagcggcgc tcgggacgcc gtcgtacgcg
     7921 ggaggggccg ggcggccggg aggagagggc acggaaggcg gggagggcgg ggaggcgacg
     7981 gacatgggag cggaacttcc ccttccttgt tgcaccgcgc ggctcggggg ctcaggcatc
     8041 gcagtcctcg gaacgttgag gtcgtctcag cgggccggtg cgtcaccggc tctcgtggca
     8101 ccgccgcaac gctaatcgtc acccagcggg ggcgcgggcg aggtcggcgt attcgccacc
     8161 cttcgccagc ccccaacgag tgaaagcatc gtcgcgcccc gtggggaagg gcggcacgat
     8221 cataaccctc gtttgccagg ggcaagttac cgtgcccgga ccgtcacgtt aacccgcccc
     8281 cgcagtccgg ttccaagtgg cgccgtgccc gggtggacac gtgggacgcc gtggtaggcc
     8341 agtctggagg gacctccgaa cacgaaggcg tccccgctgc gcaactcgac gtcggtccac
     8401 ggccgtccgc ggccgtccgg attcccgaac cggaagacgc aggtgtcgcc gaggctgaac
     8461 gagaccacgg ggtcgcggga gcgctcgtcg ctgtcacggt gcatccccat acgggccttt
     8521 ccgccgtaga agttgacgag cgcgatctcg taggggaccg tacaggaccc gtccccgtac
     8581 gcctcctcca ccgcccgccg tgcccaccgc cccaaccagg ccgggaacgg cttgaccggc
     8641 gcctcgtcgc cgtccaccgc ggtgcgggcg tagccgtacg ggtaccagtg ccagcccaga
     8701 ccgacctggc gcaccgacat ctccccgccc cggggcatgc gcacggtgcg cagcccggcg
     8761 ggcggccgcg cccaggcgcg gcaggcgtcc agcagctcac gctgcgcggc cccgtccagg
     8821 tggccgggca ggtgcaccgc gcccggcgcc acctcgaccg ccgggagccg gaacagtgcg
     8881 tcgtccacgc ctcccacctc acctccgggc accagaccga caccggaccc ggcaccgtag
     8941 ttccaccgga tctccacgct tccgccccat cccggcgcag ccccggccct tccacacccc
     9001 catgccgtag ggtcgcagtg gccggtgcgg ggctgtgcgg cgggcggcgt accgaccccg
     9061 ccgtcccggc cgcccagagc gaggccggag caaggccgga gtcaggccgg agcaaggagt
     9121 gcccatgaca tccgaaaccg tggagccagt gctggcgggg gtgcgcaact tccgcgacgt
     9181 cggcggtctg cccaccaccg acggccggcg ggtgcgccag ggcgtgctct accgcagcgg
     9241 gcacctggcg cacgccaccg aggaggacgc cgccttcctc gcccggctcg gcctgcacac
     9301 ggtcttcgac ttccgcaact ccgccgacca ggccctggag ggcccggacg tggagctgcc
     9361 gggcgtgcgc aacgtgaaca tcccgctgtc ggacccggcc gagggcgccg agttctggac
     9421 gatggtgcgc gagggcgacc tggcactgct gcggtccctg ctcggcgagg ggcaggccga
     9481 ggcccggatg gtggcgtcgt accggatgat ggtccggcag cgcacctccg agcacggccg
     9541 gctgctgcgg gagctggccg acgagagcgt gcccgccctg atgcactgcg cggcgggcaa
     9601 ggaccgggcc gggctgtcga tcgcggtgac gctgctggct ctggacgtgg agcgggacgc
     9661 gatcgaggcg gactacctgg agtccaacgc cccgcaccgc cgctaccgga tccaccgctc
     9721 ccccgacgcg ggcggcggga tgtcgcccga ggtcagagag ctgatcgcac ccctcttcga
     9781 ggtccgtccc gcctatctgc acgcggcgtt cgacaccatc accgagacct ggggcggggt
     9841 ggagtcctac ctctccgagg ggctcggcct cactcccggc ctgcgcgagc ggctgcgcga
     9901 ccgcctcctg gagccctgac cgccggagcc ccggcgtccc ggctccggcg gtgcccgccg
     9961 gccggccgcg gacagagccg gccggcctcc gcggacggag tcagccctcg cggacgacga
    10021 cgaagtccgc gagggcggcg aactgctcgc gcacccggtc cggcatgtcc acgccgtcca
    10081 gggcggcgag ggcggtggcg tgccggcggc gggcctcctg ggaggtccac tcgcggccgc
    10141 cggcctcctc gatcagcccg gcgcgggtcg cgaactcctc ctcgctgaag tcctcgaact
    10201 cccgctggct cttggcggcg tccgcggcca gcagctcccc gagccgctcg gcggccggtc
    10261 cgcccccggc cagggcggcg accaccggca gggacttctt gcgctgccgc aggtcgctcc
    10321 agggcagctt gccggtcgcc gacgggtcgc cccagatgcc cagcaggtcg tcgacggcct
    10381 ggaaggccag gcccaggtgg tggccgtacg cctccagggc gtcggcggtg gcctcgtccg
    10441 ccccgccgag gaccgcgccg atggaagtgg cgcaggccag cagcgctccg gtcttgttgc
    10501 cctccatctc caggcactcg gcgacggtga ccttctcccg gtgctcgtag gagatgtcct
    10561 gggcctgccc gtcgatgagc ttgcgggtgg ccagggtcag gcggcgggtg gcgcgcgcgg
    10621 cctcggcggt gcccagttcc agcagcacct cgcccgccag cgcgaacagg gcgtcgccga
    10681 cgaggatggc ctgtgccgga ccgtgcacct tccacacggt gtcgcggtgg cggcgctgct
    10741 cgtcgccgtc catcaggtcg tcgtggagca gggagaagtt gtggaccagt tccacggcca
    10801 ccgccccggg gacgccggtg gcgggctcgg cgcccgcggc ctcggccgac agcagggcca
    10861 gcgccgggcg caccgccttg ccgccgtcgc cgcgggccgg gttgccctgt gcgtcgatcc
    10921 agccgaagtg gtaggcggcg acggagtcca tgggcggcgc gagccgcgcc acggcggcgc
    10981 gcagcatcgg cgtggcgagg gtgcggccgc gctccagcag ctcgatgacg ctcgcggtgt
    11041 cgacggctgt gtccgtcagg gtcctcgggg tcgccggggt cacggggtct cctctgcgtt
    11101 cgatgtcgtg ctcacgccgc ctcctggaag acgtcgtcgt gcgggcggcc gagggcggcc
    11161 agcgcttccc gggcggcggt cagcccgctg cgcacggcgc cctccatcgt cgcgggccag
    11221 ccggtggcgg tccacgcccc ggccagccac agccccggtg ccccggtgcg ggcggcggga
    11281 cgcaggcgtc cgacgccggg tacgggggcg aaggtggcgg tgcgctcgcg ggtgacgaag
    11341 aagtcgcgca ccttcgcctc ccgggcggcg ggcagcagcc gggccagttc gggcaggtag
    11401 cggtcgcgca gcgcggcgac cggcaggtcg atctcgtcct gcgcggcgga ctgggacacc
    11461 gcgacgtact ggctcgccgc ccctcccggc gcactccgca gcccggaggc ggcggtgcgg
    11521 tcgaagaccc actgcacggg ggtgccgagc gcggcgagga aggggcggtg gagcaccttg
    11581 cggtcgtaga ccacgtggac gttgaggatc ggcgcgtcgc cgatgcgcag cagccgctcc
    11641 ggttcctcca gtgcgccctc ggggagcagc cggtgggcct cgcgctgggg gacggcgagg
    11701 acgaccgtgc cggcccgcag cgtccggccg gtccggcgcg cgccggtgtc caccgcgacc
    11761 cgccaggcgc cgtccggctc ccgggtcagc tcccgggcac ggccctgccg gaccacgcgt
    11821 acgcccgcct tctccagcac ggcggcggcg agcgtgtcgt gcaggtgccc cagcgggacc
    11881 cgcgaccagc cgatgtcggc cgcgccgggt tcgctgagca ggccggtggt gaggaccatc
    11941 gcggccagcc cgagcgagac gtcaggtgcg cgggcgttga gggtggcgac gccgacgagg
    12001 tcccacagcg cccgtaccgc gcgcggcgac tggccgtggc ggcgcagcca gctcccgaag
    12061 tcctgggcgt ccagggcggg gtcggagggg tcgaccctgc ccaggcgtcc gagcgccagg
    12121 gcggcccgcc ccacgcgcag ccgctcggcc ggggagaggt gggggtagcg cgccagggaa
    12181 gggcccaggt gcagcggcgc gggcagggcc gcgcgccgca gccggcccgt cctgccgcgc
    12241 gcggcgtcgt ggacggggat gtccagacgg ggctggaggg gggccagcgc gctcgcgccg
    12301 atgcgctcca ggaaccagcg gtaggcggtg cagcagcgca gatggacgtg gtggccgttg
    12361 tcgacggtca gctcgccggc cgcgccggag cggcggaagg agaaggcgag cccgccgagc
    12421 cggggcctgc tctccaccag ggtggtggcc acccctgcgt cggccaggcg cagtgcggcg
    12481 gcggtgcccg ccagccctcc tccgacgacg acggcgcgcg gatcgggtgc gccgctcatg
    12541 tcgcgctctc cccgggggcc gtgcgggcgg ccagccgggc gtcgagcccg gacaggccgc
    12601 gcagggcgac gtacgccttc tcgcgcgccg gcagggagac ccggccgcgc agtacggcgt
    12661 gcgggtcgcg ggcgatacgg gccagcaggc ggtggtagat cccggccatg gccgccacgc
    12721 aggcggccga gcggcggtcc agcagcggca gcagccgcag tccctcggcg aacagcgcgc
    12781 gggcgcggcc cacctcgaag cgcaccagcc cggcgaagtc cccgccggcg gggggcgcgt
    12841 ggcggtccag cgaggtgtcg cagccgaacg cggccagatc ctcgcggggc aggtaggtgc
    12901 ggccctccgt ggcgtcctcg cgcacgtcgc gcaggatgtt ggtcagctgc agggcgaggc
    12961 cgagggtgtc ggcgtagtgg ggggcgcggt cggcgccggg tgcgcccggc acggtgccga
    13021 acacccccag ggagagtctc ccgatggcgc cggcgacgca gcggcagtac tccttcagct
    13081 cgtcccaggt ctcgtaggcg cggccccgga cgtccatcag gactccgtcg atcagctcgt
    13141 cgagcccgcc cagcgggatc gggaagcggt ccgcggcgtc ggccagggcg acggcgaccg
    13201 ggtcggtggc gtcgtcgggg acctttccgg cgcggacgag gtcgagcagg tcgcgggtct
    13261 cctccagccg ggcgcgcttg acctccgtct ccagcgggcc gtcgccgatg tcgtccaccc
    13321 gccgcgagaa ggcgtacagg gccgacatcg cccggcgctg tgcggtgggc agcagccgga
    13381 tgccgtaggc gaagttgcgc gcctgccgcc cggtgacggc ctcgcagtag cggtaggcgg
    13441 cgaagacctg cggggagggc ggcgcctgcc gcgcggcccg ctccgcgttc gcggtccgcc
    13501 tttccaccgg gctcacctcg cccggcccag gacggccgcg gtctcgcgca gcacaccggc
    13561 cggggtgggc cgcggggcgc cgcccaggac gtcgtaccgg gcggagctca gggcgcgcag
    13621 ggccgcccgc ccgccgccgg tgaatccggc gatgaggatc ttcggtatgc cggggacgct
    13681 ggccaccagc gggactcctt cgttcagtag ttcgtgcgcg cgccgcgcct cccaggcgac
    13741 cagggcgcgc accgaggcgt tcgcggtggg cgcggcgagg tcggcctcgg tgacgcggaa
    13801 gcgctccagg tcctcggcgg ggaggtagac ccggtcgcgc agcgcgaggt cctcggcgac
    13861 gtcctggagg tgctcgatga tctgcagcgc ggtgcagacg gcgtcggagc ggcggacgcg
    13921 ctcgggagtc gtggtcccgg tgacggccag gacgagccgc cccacggggt tggcggacag
    13981 ctcgcagtag cccagcagct cctcccaggt gccgtaccgg cggaccttct ggtccagccg
    14041 gttggcctcg accagggcga ggaacggctc gggggtcagc gcgtggcggc gcacggtcgg
    14101 caccagggcg tacagcaggg ggtggcgggg gacgtcccgg ccctcggcgc ccgggtcccg
    14161 ggcggtgcgg aagacccggt gcagatcggt ctcgaaggcg tccagcaggg cgcctcggtc
    14221 gccggcccgg ccggggtcca ctcccagcag cgcggcgtcg gcgccgccgg gcggcaggtc
    14281 gccgtcgccg atgtcgtcca ggaggcggac gcagccgtac acggccatca ggtcgtcccg
    14341 ccaggcgcgg ggcaggaagc ggggggccac ggggaagttc tcgcgcgccg ccttgtcgag
    14401 gacggcgcgg ctccgcgcgt cccgcgcagg ggtcaccggg ggccgcccgc tgccatcgcc
    14461 gtcatctctc cgtccttcca ccgacagcac ccgggcaccg gcaccgcctc gtcgtccgcg
    14521 tccgtggccg ccggtcaccg cccgctgcag gagcatcata tttcgggcac gcccaggctt
    14581 cggtccggta ctcggccgac cgggtgccgg accgcccggt gcgtcgtccg ccgggaccgg
    14641 ctcagcttac gtcgtgctcg ggggcatcct tcgccgcggg tccggcgggg cgggtcgcgg
    14701 acggtcgctc cggcgcggtg aagccccgga tgaccgtggt cagggcactg gcggtgaagg
    14761 cgtcgcgctg ctccggcgcg agccggccca gcgggccgtc cagcagcagg accgccaggc
    14821 cgtgcaccgc cgcccaggcg gtgatctcgg caccgggacg ccgtccggcg ggcatccggc
    14881 cggtggcgac gagcccgtcg agggcctcgg ccagcagccg gaaggagcgg tacatccagc
    14941 gggacgggtc ctcctccggt ccgggcccgt ggccgccgtc cggcgcctcg ggggtgcggc
    15001 agaaggctgc gcggaacagg ccgggctcgg ccagcgcgaa ctcgatgtag ccggcgccga
    15061 gcgccctgac ccgctcctcg gccgcctctc cggcactcgg cgacccgcca cgggcgccgg
    15121 ccgaccgctc catcgtctcc gcgagccccc gctgcccctg ctccttgacc gccatcagca
    15181 ggtcgccctg gcctgtgaag tggcggtagg cggccgtcgg cgagaccccg accctgcggg
    15241 cggcggcgcg cagcacgacg gcttccggcc cgccgtcgcg tgcgaggtcc gtcgccgcct
    15301 cgatgagcgc gttgcgcaga tctccgtggt ggtagccgct ctttccggtg ccttcggtcc
    15361 gcatcattcg atactgcctg atgttgacat cattaacatc cctctgccag agtcgaagtt
    15421 aacgccgtaa acatcctatg gcgcgcgccc gcaagtgagc gagagggaag accatgctgt
    15481 cgtggatcgc cgatctggta ctgcgccgcc cccgaacggt gctggtggcc gcactcgtct
    15541 ccgtgctggc catggcggcc gtcggcatcg gcgccttcgg caagctccag agcggcggtt
    15601 tcgacgaccc cgacgcccct tccagtcgcg ccaccgccct gatcgacgag aagttcggcg
    15661 gcgagaccaa tctcgtcctg ctggtacggg cggacggtgg cggacggctg gactcccccg
    15721 ccgccgagcg ggcgggccgg gagatcgccg acgggctgaa ggacgagccg ggcgtgtccg
    15781 gcgtggtctc ctactgggac accggcggct ccgcgctcac gtcccgcgac ggcgaccagg
    15841 cgctgatcct cgcccacatc gagggcgacg acaccgagcg caccgaccgc gccggcgaac
    15901 tctccgagaa gtggtccggt gaccggggcg ccgtcaccgt gcacaccggc ggccaggcgg
    15961 ccgtcgccag cgacatcacc tcccagatat ccaaggacct cgccatcgcc gaggcgatcg
    16021 ccgtccccat caccctgatc ctgctggtga tcgccttcgg cagcgtcgtg gccgcgctgc
    16081 tgccgctggc catcgggctg atcgcggtca tgggcacctt cgccgagctc tacgtgctcg
    16141 gcagcatcac cgacgtctcg atcttctcga tcaacctcac caccgccctc ggtctcggcc
    16201 tgggcatcga ctacggcctg ctgctggtca gccgcttccg cgagcggctg accgagggcg
    16261 acgacgtacc ggacgcgctg cgcaccaccg tggccaccgc gggccgcacc atcgccttct
    16321 ccgccgccac cgtcgtcgcc gcgctcgccg cactgctgct cttcccgccc ttcttcctgc
    16381 gctccttcgc ctacgccggg atcggcgtcg tcgcgatcgc cgcggtcggc gcgctggtgg
    16441 tcgtcccggc cctgctggca gtgctgggcc accgcgtcaa cagcggccgg ctgccctggg
    16501 cggaatccgt acggcgcccc gacgcgccgg tgtggggccg cctggcctcg gtggtgatgc
    16561 gccgccccgc actcaccgcg ctgccggtcc tggccgtgct gctgctcgcc gcgagcccgc
    16621 tgctgggcgc gtccttcggc aaccccgacg agcgggtact gcccgacagc gcgcccagcc
    16681 gccaggtggc caccgccgtc gacgaggact tcggccgcga cgacacctcg gccgtccaga
    16741 tcgtcaccac cggcccggtg gacgccgccg ggctggacgc ctacgccacc gcggtctccc
    16801 gcctcgacgg cgtcacccgt gtccaggcct cctccggcac ctaccaggac ggcgaggccg
    16861 ccccgcccgg cccggtcaac gccgcgctcg gccgggacga cgcccagcgg ctgaccgtcg
    16921 ccaccgagcc ggagtccgga tccggcgcgg ccgaggacct ggtgcacgac atccgcgcgg
    16981 tgccggcccc tgacggggtg gaggccctgg tcggcggccc ggacgcccgg ctggtggaca
    17041 ccaaggccgc catcggcgac cggctgcccg ccgcgatcgc ctgggtcgcg ctgaccacct
    17101 tcgccctgct gttcctgttc accggcagcg tcgtgcagcc gctgcgcgcg ctggtgctca
    17161 acaccatcag cctcaccgcc gcgatcggcg cgatggtgtg gatcttccag gagggcaacc
    17221 tgtcctcggt gctgggcttc accccgatgc cgatgaacac ctcgatgacc gtgctgctgt
    17281 tctgcatcgt cttcgggctg tcgatggact acgaggtctt cgtgaccagc cggatcaagg
    17341 aactgcacga cgcgggcgag gacaccggga ccgccgtcac ccacgggctg tcgcgcaccg
    17401 ggcggatcgt caccatggcc gccggcctgc tggcggtgag cctgttcgcc ttcaccacca
    17461 gcgagatcag cttcatgcag atgttcggcc tcggcagcgg gctggccatc ctgatcgacg
    17521 cggtcgcggt gcgcggcgta ctcgtcccgg ccgcgatgcg gctgctgggc cgcggcgcct
    17581 ggtacgcgcc gaaggccctg cgccggctgc acggccgggt ggggctgtcc gaggccgccg
    17641 ctccccctcc ggcccccgcc gagccccggc gcgagcccgc cggaatctga cccggccccc
    17701 ggcggaccgc ccggacgcgg accggccccg cccctgacag gggcggggcc ggtccgcgtc
    17761 cgggctcggc ggcacgagcg tcacttgcgg gtgaactcct cgtacgcctt catcacttcc
    17821 tcggtcgggc cgtccatgcg cagctcgccg ctctccagcc acagcacccg gtcgcaggtg
    17881 tcccggatgg acttgttgtt gtggctgacc aggaagaccg tcccggcctc ctggcgcagc
    17941 tcgcggatgc gggcctccga gcgcctctgg aacttcttgt cgcccgtcgc cagcgcctcg
    18001 tcgatcatca gcacgtcgtg gtccttggcg gcggcgatgg agaaccgcag ccgggccgcc
    18061 atgccggagg agtacgtccg catcggcaga ctgatgaagt cgcccttgtc gttgatgccg
    18121 gagaagtcca cgatgtcctg gtagcgctcc aggatctggg ccctggacat gcccatcgcc
    18181 agtccgccca gtatgacgtt gcgctcgccg gtcaggtcgt tcatcagcgc ggcgttgacg
    18241 cccagcagcg agggctggcc gtcggtgtag accctgccgc gctcggccgg cagcagaccc
    18301 gcgatggcac gcagcagcgt ggacttgccc gagccgttgg atccgatcag cccgatcgcc
    18361 tcgccacggt aggcggtgaa gctgacgccc ttgaccgcgt gcacctcgcg catgcccgcc
    18421 ggggccttgc ggcgcaggat gcggctgagg gccgccgtgg cgctcccccg gccccggccg
    18481 ccgccgttga cgcggtagac gatgtgcagg tcgtcggcga tcacggtcgg ccgccgttcc
    18541 acgggagcgg cctccgccgc cccctcgtcc ttgtgcgccg acgctgcggc tgcgctcttc
    18601 tcagccacgg ccataacgct cctccgcctt ccagaagtac acgaacccgc cgatgccgat
    18661 caccagggcc cagcccgcgg ccagcagcca cacgtacccg tccagactct ggtggtgcgg
    18721 tccgtcgatc agcgcgtagc gcatcagttc catgtagacc gccgccgggt tggcctccag
    18781 caccccggcc agccagcccg gggcgttcgc cttctccagc atgtaggcca gcgggaacat
    18841 cacgccggag gcgtacatcc aggtacgcag cacgaacggc atcagctggg ccaggtcggg
    18901 ggtcttgctg cccagccggg ccatgatcat cgccaggccg gtgttgaaga ggaactgcag
    18961 cagcagggcc ggtaccacca gcagccacag cggaccgggg tagtgcccga gtcccaccag
    19021 gatgacgacc aggacgatca tcgagaacag cagttgctgg agctgctgga gggagaagga
    19081 gaccggcagc gaggccctcg ggaagtgcag ggcccgcacc agccccaggt tccccgagat
    19141 ggaccgcacg cccgacatca ccgaggtctg ggtgaaggtg aagacgaaca cccccgtcac
    19201 caggaacggg atgtactcgt cgttctccat gccgccgcgt cccccgagca gcaggccgaa
    19261 gatgaagtag tagacggccg cgttgagcag gggcgtcagg acctgccaca cctggccgag
    19321 cttggcctgg ctgtactggg cgtgcagctt ggcccgggag aaggcgagga tgaagtgccg
    19381 ccgtgcccac agctgccgga cgtactccgt cagggagggc cgggcgccgc tcaccgtcag
    19441 cccgtacttg gcggcgagtt cggccgggga caggccgtcg tctggtgaac gcgggggctc
    19501 gctcgtcgcg atcgcaccgc cgtgcgttgt gtcgctcacg ttgaaacttt cgtcctcaca
    19561 gtgcgcagcc gggatggaat gagcgcaggg agcccggccc tgtcaccgga cccgatgctc
    19621 tcagacagag cttgtcagat gacgggaggg cggcccagcc gggtcagacg ccacaccgta
    19681 cgccacttca tgggacggcg ggggccgcac ggggtcgtcc agccctcccg gaagccgccc
    19741 agccaggcgc gcagggcggg gcgcgagggg cgccgggcga gggtcagcag cagccatacg
    19801 cccaggtaga gggggatcag cggcagcggc aggttgcgcc gggccagcca cacgcggttg
    19861 cgggcgacca tgcggtggta gaccgcgtgg cggctgggga gggtggtggg gtggtggagc
    19921 accatgtccg cgcggtagtc gatcatccat cccgcgtcca gcgcccgcca ggccaggtcg
    19981 gtctcctcgt gcgcgtagaa gaactcgtcc ggcagcccgc cgacctgccg gaagaccgcc
    20041 gtgcgcacgg cgttggcgcc gccgaggaag gtcgtcacgc gcgaggagcg catcgggtcc
    20101 gaggcgcgca gccgcggtac gtggcggcgc tgggtggccc cggtgtccgg gtcggcgatg
    20161 cggaagctga tgatgcccag ctccgggtcg gcggcgaacg cctgccggac cagctcggcg
    20221 gtgtcggtgt tcggcagcag cccgtcgtcg tcgaggaaga gcagggcgtc cacctcgctc
    20281 ccgccgggcc cgaacgcctc gatgccgacg ttgcggccgc cggggatgcc caggttctcc
    20341 ggcagctcca ccgtccgcac cccctccggg agctccggca gcggggcgcc gttgccgacg
    20401 accacgacct ggaccgggtc gccgtcctgc ttggcgaccg agtccagcag ggcgcgcagc
    20461 tcctcggggc ggttgcccat ggtcaggacg accgcgccca gtgtcagggg cctgccggag
    20521 gcggactccg cgccctccgt catgtcactc aacgtcgttc accgccctca ccgcagccgg
    20581 ctcgaggcca ggatggacac caggtgcagc agcgtctgca ggaccgcgat ggccgccagg
    20641 acggcgacgc ccagccgggt gaagaacagg ccgccgtgca gtacgtccgc caccgcgacc
    20701 agcaggatca ccagggacgc ctcgacgccg ccgaccagcc ggtggaactt cagggccgcg
    20761 gccgcccggc gggccagtgc cagtcccgag gagcggggca cggccgcctc gtccttcacg
    20821 gccggcaggc cgctgcggga gcgggccacg tccaccaggt cggtctcggc cttgatcagg
    20881 atcgcgccca gcgcggccac ggtgcccagg aaggcccaca gccagttcgc ggaggccccc
    20941 tcggtgcgga agacgtcggc ggcccgcacc ccgaagccga ccagcagtgc cgcctcggcc
    21001 aggtagtgcc ccacccggtc gaggtagacg ccggtgatgg aggtctgctt ccgccagcgg
    21061 gcgacctcgc cgtccacgca gtccagcagc aggtagaact ggatcagcag ggcggcgagg
    21121 acggccccgg tcaggccggg caccagcagt acggcgccgg ccgccacacc ggcgacgacc
    21181 atcaggtagg tgagctggtt gggcgttatc cgggtgttca ccagatgccg ggtccagcgc
    21241 agcgagatct cccgcatgta caggcgcccg gcccagtgct caccgctgcg ccggtccttc
    21301 accccggcgg ggtggacgac cggacggagt tcagctactg acggctttga catagtcggc
    21361 gtacgcgtcc ctgatctggt cggtggacag gtccaggtgc tcgatgatcg tgtagcgccc
    21421 gggccgggtc tgcggcgcgt actccaccgc gcgcacgaac tcgtcctcgt tgaagccgat
    21481 ctcgccgggc agcacgggca ggccgtggcg gcgcagcacg tcgacgatca gcgccgtctg
    21541 ctcctccgcc ccgcgcaggt gcatcgcgaa ggccgccccg agcccgcact gctcgccgtg
    21601 ggcggcggcg cgcttggggt agagcaggtc gaaggcgtgg ttgatctcgt gacaggcgcc
    21661 ggaggcgggg cggctgtcgc cggcgaccga catggagatg ccggtgagca ccagcccttc
    21721 ggccagcacg gtgaggaact cgtcgtcgcc gcagccgccc gggtggcgca gcaccgcctc
    21781 gccggcctgg cgggccatgg cggcggccag gccgtcgatc gactcgccgg tgaccttgtg
    21841 ggagagctcc cagtcggcga cggcggagat gttggagatc acgtcgccga cgcccgagcg
    21901 cacgaaacgg atcggggcct cgcggatgac gtcgaggtcg atcacgatcg cgatcgggtt
    21961 cggcactccg tacgagccgc ggccggcgtc gttgtcgagc gtggcgacgg gggagcacag
    22021 gccgtcgtgg ctgaggttgg tggcgacggc gaccagcggc aggccgatgc gcgcggcggc
    22081 gaacttggcg cagtcgatga tcttgccgcc gcccatgccg acgaccgcgt cgtagtggcc
    22141 ggacttcatc gcgtcggcca gcttgatcgc gtcgtccagc gtgccgccgc cgacctcgta
    22201 ccagtcggcg cccggcaggg cgggcgcgaa ccgctcgcgc agggccgcgc ccgagccgcc
    22261 gctgatggcg atggcgagct tgccggaggc cgagatgcgc tggtccacca ggaggcctgc
    22321 cagatcgtcc agcgcaccgg gcctgatgtc gacgacgacc ggcgacggaa tgagccgggt
    22381 cagtactggc acgcgatctc ccgcgccttg ttcaggtcgt cgtggttgtc gatctcgacc
    22441 cacctgacgt cgccgatcgc ggcggtgtcg atggtgaggc cgcggtcgac catctcctgg
    22501 tagccgtcct cgtagtagag ctgcgggtcg cgctcgtagg tggccttcag cgcgtcggcc
    22561 aggtcggcgg cggcgtcgcc ctcgatgagg gtcacgccga tgtactcgcc ggtggcgtcg
    22621 gccgggtcca tcagcttggt gatgcggcgc acgcccctgc cgggctcggt gacgaccttc
    22681 atctcctcgt cggccagctt cttgaccgtg tcgagggcga ggatgatccg ctgccccttg
    22741 ccgcgggcct ccagcagggt ctgctcgacg gagacggggt ggacggtgtc gccgttggcc
    22801 aggatcacgc cctccttgat gacgtcgcgg gcgcaccaca gggagtaggc gttgttccac
    22861 tcctcggcct tgtcgttctc caccaggtgg agcttgacgc cgtacttctt ctccagggcg
    22921 gccctgcgct cgtggacggc ctccttgcgg tagcccacga ccacggcgac gtcggtgagg
    22981 ccgacctcgc ggaagttgcc gagggtgagg tccagcacgg tggtggtgcc ctcgcccgcc
    23041 gggtccaccg gcaccagggc cttgggaagg gtgtcggtgt aggggcgcag acgccgtccg
    23101 gcgccggcgg ccagcacgag gccgatcatg cgggttctcc tgtttcgtcg tgtacggcgg
    23161 gtgcgtgtga ggacacccag aaacggacgc tctcggtgat caccgtgagc gccagggccc
    23221 cggccagggc cgtgagcgcg atcgtgaagc cctgccccgc ggcccagagg gcggcggcgg
    23281 ccgtgaccgc cacagcgcgt ccctcgtgcc cgccgatcgc ccgcaccagc aggcgcgggg
    23341 gggcgccggt gccgccgcgg atgcggtaca ccgtgtcgta gtgatggtag gcgaccgccg
    23401 cgaccagccc gaacgcggcg ggcagggccc cctccgcgtc cgaacgggcg gccagcgcca
    23461 ggacggtggt gtactccgcc gcacggaaga ggggcgggac cagccagtcc agcgcgccct
    23521 tgagcggacg ggcgacggcc agtccggaca gggcggcgta gccgagcgcg gcggccggca
    23581 gccagggccc gaccggcgcc cacagcgctg cggccaccag ggcggccgag ccgagcaggg
    23641 cgagggcagg ggcggcgaac ccggacggcc gcccgccgcg ccgccggaac gcggcggccc
    23701 gcgccacgcc ctcggccagc ggcccggagt cggccagctc ggccagggcc cgcgcggcgc
    23761 cgtcggtgcg cacgcccttg cggctgaggg agcgcagcac ccgtccggcg gtggtgtagc
    23821 aggcggcgaa cgcgcatccg gccagcagca cgacgaaggt ggtgcggggc gtggtgagcg
    23881 cggtgaggac ggcgatcagc gcccagcgtt cgccgatcgg cagcacgatc atgcggcggg
    23941 cccacaccgt ccagccgacc ctgtcgagtc tcccggacag ggcggcggcg gggttggcgc
    24001 tcccggccgc cggctccccc tcgcgctccc ccgtgtgctc cccgccggcc tccctctcgt
    24061 ggcggtcggc ctcgttgaag gagaagtcca ccacgtggcg gcaggtctgg agcaccatcg
    24121 cgcccagcgc cagggcccac acgtcgtcac cgccgcgggc cgcgccgagg gccaggcccg
    24181 cgtagtaggc gtactccttg gcccggtcga aggtggcgtc cagccaggcg ccgagcttgg
    24241 agtacttcag cgcgtagcgg gcgagctggc cgtcggtgca gtccagcacg aacgatgcga
    24301 tcagcagcgc cccggccgcg acgaagccgc cgcgggtgcc ggtggccgca caggcggcgg
    24361 cgatcagcgc ggtgagcagc gaggcggtgg tcacctggtt gggggtgagt ccgcgccggg
    24421 cgcaccagcg ggcgat
//
