LOCUS NZ_FOET01000001 10405 bp DNA linear CON 03-MAY-2024 DEFINITION Streptomyces radiopugnans strain CGMCC 4.3519, whole genome shotgun sequence. ACCESSION NZ_FOET01000001 VERSION NZ_FOET01000001.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces radiopugnans ORGANISM Streptomyces radiopugnans Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 AUTHORS Varghese,N. and Submissions,S. TITLE Direct Submission JOURNAL Submitted (27-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800 Mitchell Drive, Walnut Creek, CA 94598, 94598, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_900110735.1-RS_2024_05_03 Annotation Date :: 05/03/2024 01:56:50 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 5,515 CDSs (total) :: 5,440 Genes (coding) :: 5,315 CDSs (with protein) :: 5,315 Genes (RNA) :: 75 rRNAs :: 4, 4, 5 (5S, 16S, 23S) complete rRNAs :: 4 (5S) partial rRNAs :: 4, 5 (16S, 23S) tRNAs :: 59 ncRNAs :: 3 Pseudo Genes (total) :: 125 CDSs (without protein) :: 125 Pseudo Genes (ambiguous residues) :: 0 of 125 Pseudo Genes (frameshifted) :: 41 of 125 Pseudo Genes (incomplete) :: 106 of 125 Pseudo Genes (internal stop) :: 6 of 125 Pseudo Genes (multiple problems) :: 26 of 125 CRISPR Arrays :: 1 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 05:58:30 NOTE :: This is a single region extracted from a larger record! Orig. start :: 1025799 Orig. end :: 1036204 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to FOET01000001.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..10405 /candidate_cluster_numbers="1" /contig_edge="False" /product="ectoine" /region_number="3" /rules="ectoine_synt" /tool="antismash" cand_cluster 1..10405 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="ectoine_synt" /kind="single" /product="ectoine" /protoclusters="1" /tool="antismash" protocluster 1..10405 /aStool="rule-based-clusters" /category="other" /contig_edge="False" /core_location="[5000:5405](-)" /cutoff="20000" /detection_rule="ectoine_synt" /neighbourhood="5000" /product="ectoine" /protocluster_number="1" /tool="antismash" proto_core complement(5001..5405) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="ectoine_synt" /neighbourhood="5000" /product="ectoine" /protocluster_number="1" misc_feature 132..147 /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2, activator of antibiotic production, confidence: medium, score: 17.11" /tool="antismash" misc_feature complement(375..393) /note="TFBS match to LexA_variant_3, Repressor of DNA damage response, confidence: weak, score: 19.24" /tool="antismash" misc_feature 473..488 /note="TFBS match to ColR, Phenol-responsive regulator, confidence: weak, score: 17.95" /tool="antismash" gene 542..2548 /locus_tag="BMY40_RS04455" /old_locus_tag="SAMN05216481_101901" CDS 542..2548 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014174265.1" /locus_tag="BMY40_RS04455" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SAMN05216481_101901" /product="beta-galactosidase" /protein_id="WP_093655454.1" /transl_table=11 /translation="MVRLAYGGDYNPEQWPEEVWHEDVALMREAGVTTVSVGIFSWAMI EPAEGVFDFGRLDRIIELLHGAGIGVDLATPTVVPPAWFYRAHPEALPVSREGVRWEFG SRGAICHNSPAYQQASARIARALGERYGRHPAVVMWHVHNEYGVPVLECYCETSAAAFR TWLRERYTTLERLNAAWGTAFWGQTYGDWEEIAPPRATPTVCNPAQRLDYARFASDSAL ANFRRERDLLHELSPGVPVTTNFMVSPTQCDTIDYWAWGREVDIVTNDHYLVAEDERNH VNLSMAADLTRSVAGGEPWLLLEHSTSGVNWQPRGIAKRPGEMARNSLAHIARGSEGAM FFQWRASRSGAEKFHSAMVPHAGTDSRIWREVVSLGADVAALEEIRGTRTVADVAVVWD WQSWWAQKLEWRPSQDLDARERAEAWYAALFDRHLTADFVPPRTDPAKLAAYPLVVVPA LYLASAEAGEDLRAYVAGGGTLVVSYFSGIVDEHDAVHPGPHPGALREVLGLTVEEFQP LRAGRTVTVLGSGVPSLEADVWAETVVARGAETVWSYGGGPAAGGPAVTRNRLGEGTAW YVSTRLGPGGLDAVLAAACADAGIAPREEIPRDVEVVRRSGQSGTYLFVLNHTGADAKV PLEASGTELLGGARVAGRLAVPAGGVRVVRLDG" gene 2684..3805 /locus_tag="BMY40_RS04460" /old_locus_tag="SAMN05216481_101902" CDS 2684..3805 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_020135913.1" /locus_tag="BMY40_RS04460" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SAMN05216481_101902" /product="arabinogalactan endo-1,4-beta-galactosidase" /protein_id="WP_093655456.1" /transl_table=11 /translation="MRRRTVLRLGAVALAAPALATAAPGTAAAAPRLRVRGADVSSLAK GEDLGGVYHHADGRRDDAVRILAGAGVNWGRLKVWVDPADGYHTRPHILRTARRLHAAG MKLLVDFHYSDTWADPGKQFKPAAWEDLHGAALERAVRDHTADILGALRAQGTPAAMVQ IGNEINGGMLWPDGSTDDWPRLAGLLTAGAEAARAASPGIRVALHLAEGGRGADTRWWF DNAVAHGVPFDAIGLSFYGYWHGTLADLQANLNDVSARYRRDVFVAETAYPFRLDSEDF LENIIDRPSELVPGYPATPEGQAAWLRDITAVVAAVPGGRGLGLFWWEPTWTAVPGNGW DPADPASGNGWENQALFDYDSRALPALEVLGRG" gene complement(3964..4863) /gene="thpD" /locus_tag="BMY40_RS04465" /old_locus_tag="SAMN05216481_101903" CDS complement(3964..4863) /EC_number="1.14.11.55" /codon_start=1 /gene="thpD" /gene_functions="biosynthetic-additional (rule-based-clusters) PhyH" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014671935.1" /locus_tag="BMY40_RS04465" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SAMN05216481_101903" /product="ectoine hydroxylase" /protein_id="WP_093655457.1" /sec_met_domain="PhyH (E-value: 4.8e-39, bitscore: 130.7, seeds: 39, tool: rule-based-clusters)" /transl_table=11 /translation="MTTAPERTADLYPTRGASEVITPRQDPTVWSAPGTPGPIEAADLA AYDRDGFLAIDQLITPDEVEVYNRELNRLVSDPLIRADERSIVEPKSQEIRSVFEVHKI SEVFANLVRDPRVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLP NMRTVSVSIALTENYETNGALMIMPGSHRTFLGCAGATPKDNYKKSLQMQDAGTPSDEA LTRLAGEHGIRLFTGKPGSATWFDCNCMHGSGDNITPYPRSNVFIVFNSVENTAVEPFA APIPRPEFLGARDFTPVR" gene complement(5001..5405) /locus_tag="BMY40_RS04470" /old_locus_tag="SAMN05216481_101904" CDS complement(5001..5405) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) ectoine: ectoine_synt" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014141824.1" /locus_tag="BMY40_RS04470" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SAMN05216481_101904" /product="ectoine synthase" /protein_id="WP_093655460.1" /sec_met_domain="ectoine_synt (E-value: 2e-54, bitscore: 178.7, seeds: 10, tool: rule-based-clusters)" /transl_table=11 /translation="MIVRSLQEIEDTDRHVRSASGTWESKRIVLAKERVGFSLHETVLY AGTETSMWYANHVEAVLCVEGEAELTNDETGEKHWITPGTMYLLDGHEKHTLRPKTDFR CVCVFNPPVTGREDHDENGVYPLLTEPDES" gene complement(5537..6805) /gene="ectB" /locus_tag="BMY40_RS04475" /old_locus_tag="SAMN05216481_101905" CDS complement(5537..6805) /EC_number="2.6.1.76" /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate transaminase activity [Evidence IEA]" /NRPS_PKS="Domain: Aminotran_3 (28-365). E-value: 2.1e-72. Score: 235.9. Matches aSDomain: nrpspksdomains_BMY40_RS04475_Aminotran_3.1" /codon_start=1 /gene="ectB" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_3" /gene_functions="biosynthetic-additional (smcogs) SMCOG1013: aminotransferase class-III" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018835756.1" /locus_tag="BMY40_RS04475" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SAMN05216481_101905" /product="diaminobutyrate--2-oxoglutarate transaminase" /protein_id="WP_093655462.1" /sec_met_domain="Aminotran_3 (E-value: 8.4e-76, bitscore: 251.0, seeds: 13, tool: rule-based-clusters)" /transl_table=11 /translation="MTITQPDLSIFQTLESEVRSYCRGWPTVFDRARGSYMYDEDGHAF LDFFAGAGSLNYGHNNPVLKRALLDYLERDGVTHGLDMSTTAKRAFLETFQEVVLRPRG LDHKVMFPGPTGTNAVEAALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA GVPLVHGTPMPFDNYLDGKVEDFLWFERLLQDSGSGLNRPAAVIVETVQGEGGVNVARA EWLRALADLCKRQDMLLIVDDIQMGCGRTGGFFSFEEAGITPDIITVSKSISGYGLPMA LTLFRPELDVWEPGEHNGTFRGNNPAFVTAAAALDTYWADGQMEKQTLARGEQVEAALC AIAGEHRGGVAGFRGRGLVWGLAFPDAGRAGWVCSRAFELGLLVETSGPESEVVKLLPA LTISPEELDEGLRTLARAVRETA" aSDomain complement(5711..6721) /aSDomain="Aminotran_3" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_BMY40_RS04475_Aminotran_3.1" /evalue="2.10E-72" /label="BMY40_RS04475_Aminotran_3.1" /locus_tag="BMY40_RS04475" /protein_end="365" /protein_start="28" /score="235.9" /tool="antismash" /translation="FDRARGSYMYDEDGHAFLDFFAGAGSLNYGHNNPVLKRALLDYLE RDGVTHGLDMSTTAKRAFLETFQEVVLRPRGLDHKVMFPGPTGTNAVEAALKLARKVKG RESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGVPLVHGTPMPFDNYLDGKVEDFLWFER LLQDSGSGLNRPAAVIVETVQGEGGVNVARAEWLRALADLCKRQDMLLIVDDIQMGCGR TGGFFSFEEAGITPDIITVSKSISGYGLPMALTLFRPELDVWEPGEHNGTFRGNNPAFV TAAAALDTYWADGQMEKQTLARGEQVEAALCAIAGEHRGGVAGFRGRGLVWGLAFP" gene complement(6886..7422) /gene="ectA" /locus_tag="BMY40_RS04480" /old_locus_tag="SAMN05216481_101906" CDS complement(6886..7422) /EC_number="2.3.1.178" /GO_function="GO:0033816 - diaminobutyrate acetyltransferase activity [Evidence IEA]" /GO_process="GO:0019491 - ectoine biosynthetic process [Evidence IEA]" /codon_start=1 /gene="ectA" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019545554.1" /locus_tag="BMY40_RS04480" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SAMN05216481_101906" /product="diaminobutyrate acetyltransferase" /protein_id="WP_093655464.1" /transl_table=11 /translation="MPEGLKLDAPRVEDGAAIWRIARDSRVLDLNSSYSYLLWCRDFAA TSAVARDGDGEPVGFITGYVRPRHPRTLVVWQVAVDHGQRGRGLAAAMLDGLTTRAAEE LGIDGIETTITPDNTASNRLFTSYAERHGAPVRREVLFEGALFPEEGHEPEVLYRIGPV PALASTATAPAAAGG" misc_feature 7494..7510 /note="TFBS match to ZuR_variant_2, Zinc-responsive repressor, confidence: weak, score: 16.6" /tool="antismash" misc_feature complement(7639..7656) /note="TFBS match to ArcA, Repressor of carbon oxidation, confidence: weak, score: 16.31" /tool="antismash" gene complement(7820..8548) /locus_tag="BMY40_RS04485" /old_locus_tag="SAMN05216481_101907" CDS complement(7820..8548) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003976943.1" /locus_tag="BMY40_RS04485" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SAMN05216481_101907" /product="hypothetical protein" /protein_id="WP_093655466.1" /transl_table=11 /translation="MTDRPDVVARLRVAADGHRPDRARMWARVSARLPAGSREEAGRVR PRPRRAWPRMAGAAGGLVAVLAAGGLAVDRVAGGGEPWGERAPAGAGVRDGGPPSAAPS AGGGEPGPREDRLRSRGVLGPGNNAHWAQSGVVLHCGERLASLTVELRVAPAGGVRHTG FWSTLPADDFEVTVREEGGALVYRWTLRKGRAVPPGEHRFVGQYGHAEGLRDAGRDSYT VHATGPGGPVSAEGDFRRVP" gene complement(8545..9105) /locus_tag="BMY40_RS04490" /old_locus_tag="SAMN05216481_101908" CDS complement(8545..9105) /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_function="GO:0016987 - sigma factor activity [Evidence IEA]" /GO_process="GO:0006352 - DNA-templated transcription initiation [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1032: RNA polymerase, sigma-24 subunit, ECF subfamily" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019433895.1" /locus_tag="BMY40_RS04490" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SAMN05216481_101908" /product="SigE family RNA polymerase sigma factor" /protein_id="WP_093655468.1" /transl_table=11 /translation="MDAPTEEFHAFFDRYYADLSRFAYLLLGDSEGADDLAADALVAVW RRWDSVRADGHPLAYARSVVAGMARTRQRSLVRERRRIALFWSHRPDRIDDPDVPAVLD VRDALARLPLRKRACVVLRHAFDLSEKETARTLGISVGTVKSQTSRGIAELERMLAPAR TGPERAYETVRALRAGPAGRSGW" gene 9201..10298 /locus_tag="BMY40_RS04495" /old_locus_tag="SAMN05216481_101909" CDS 9201..10298 /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Amidohydro_1" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017238577.1" /locus_tag="BMY40_RS04495" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="SAMN05216481_101909" /product="amidohydrolase family protein" /protein_id="WP_093655470.1" /sec_met_domain="Amidohydro_1 (E-value: 1.3e-19, bitscore: 66.5, seeds: 57, tool: rule-based-clusters)" /transl_table=11 /translation="MSERGNFHIRGRVLTGPGPDDVRDEMWVVDGRITYERPTGPLETA TVEGWVLPGLVDAHCHVGLDAHGAVDDATSEKQALTDRDAGTLLIRDAGSAADTRWIDD REDLPRIIRAGRHIARTRRYIRNYAHEIEPGDLAAYVRGEARRGDGWVKLVGDWIDREQ GDLAPCWPRGAVEAAIAAAHEEGARVTAHCFAEDSLRDLVEAGIDCVEHATGLTEETIP LFAERGVAIVPTLVNIATFPRLAEGGEKKFPRWADHMRRLHERRYDTVRAAYDAGIPVF VGTDAGGSLPHGLVADEVAELVAAGIPPVDALSATTWAARAWLGRPGLEEGAEADLVVY EADPRADVRVLAAPRAVLLRGRAVR" ORIGIN 1 ccttctccgc gccggccacc tcgcccgata tgtcggccag cacgtcgttg ccgaccaggg 61 tgggcagcgc ctggtactcg gcctgcacca ggtcgggggc ctcaccagcc ttggccgcgg 121 tgatggtctt ggtcaccagg tcgtccccgc tggcctgctt cttgaccacc accttgacgt 181 ccgggttctc ctcgttccag agggcgacga ccttgtccat gccgggcgcc caggcccagt 241 aggtcagttc cgccgggccg gaggcggcgg agtcgtcgcc cgaggagccg cagccggtga 301 ggacggctgc cgccagagcg gccgcggtgc acgccgcgac ggtgcggtgg ttcatgtttc 361 ctccctgaca aggcgctgtg aacgtgcaca gtagagaaac ccgactgact cttgtcaatg 421 gttcggggct tgatgttttc taggtgatgc agtcgacgtg cggctgtgaa cgttcccagt 481 tctttcccag ttccttcccg gtccggctca ctcgggccgg gacttcgacc caggaggtcg 541 tatggtgcgc ctcgcctacg gcggcgacta caaccccgag cagtggcccg aggaggtctg 601 gcacgaggac gtcgcgctga tgcgtgaggc cggtgtgacc acggtcagcg tcggtatctt 661 ctcctgggcg atgatcgagc ccgccgaggg cgtcttcgac ttcggacggc tcgaccggat 721 catcgagctg ctgcacgggg ccggcatcgg cgtcgacctg gccaccccca ccgtggtgcc 781 gcccgcctgg ttctaccgcg cccaccccga ggcgctgccc gtcagccggg agggcgtgcg 841 ctgggagttc ggctcgcgcg gcgcgatctg ccacaactcg cccgcctacc agcaggcctc 901 cgcccggatc gcccgcgcgc tgggcgagcg ctacggaagg catcccgcgg tcgtgatgtg 961 gcacgtccac aacgagtacg gcgtacccgt cctggagtgc tactgcgaga cctccgccgc 1021 cgccttccgc acctggctgc gggagcgcta caccaccctg gagaggctca acgccgcctg 1081 gggcaccgcc ttctggggcc agacctacgg cgactgggag gagatcgccc cgccccgggc 1141 gacccccacc gtctgcaacc ccgcccagcg cctggactac gcccggttcg cgagcgacag 1201 cgccctggcg aacttccgcc gcgagcgcga cctgctgcac gagctgtccc cgggcgtccc 1261 ggtcaccacc aacttcatgg tctcgcccac ccagtgcgac accatcgact actgggcctg 1321 gggccgcgag gtcgacatcg tcaccaacga ccactacctg gtggccgagg acgagcgcaa 1381 ccacgtcaat ctgtcgatgg ccgccgacct gacccgctcg gtcgccggcg gcgagccgtg 1441 gctgctgctg gagcactcca ccagcggcgt caactggcag ccgcgcggca tcgccaagcg 1501 ccccggcgag atggcccgca actcactggc ccacatcgca cgcggctcgg agggggcgat 1561 gttcttccag tggcgcgcct cccgctccgg cgcggagaag ttccactcgg cgatggtgcc 1621 gcacgccggc accgacagcc ggatctggcg cgaggtggtc tcgctcggcg cggacgtcgc 1681 cgcgctggag gagatccgcg gcacccgcac ggtcgcggac gtggcggtcg tgtgggactg 1741 gcagtcgtgg tgggcgcaga agcttgagtg gcgccccagc caggacctcg acgcccgcga 1801 gcgcgccgag gcctggtacg ccgcgctctt cgaccgccat ctgaccgccg acttcgtccc 1861 ccctcggacc gatccggcga agctggccgc gtacccgctg gtggtggtcc ccgccctcta 1921 cctggcctcg gcggaggccg gtgaggacct gcgcgcctac gtcgccggcg gcggcaccct 1981 ggtggtctcc tacttctccg gcatcgtcga cgaacacgac gccgtccacc ccggccccca 2041 cccgggcgcg ctgcgggagg tgctcgggct gacggtcgag gagttccagc cgctgcgggc 2101 gggccggacg gtgaccgtcc tcgggtccgg ggtcccctcg ctggaggccg acgtgtgggc 2161 cgagaccgtc gtggcgcggg gcgccgagac ggtgtggtcc tacggcggcg gcccggccgc 2221 gggcggtccc gccgtcaccc ggaaccggct gggcgagggc accgcgtggt acgtctcgac 2281 gcgcctgggc ccgggtgggc tcgacgccgt gctggccgcc gcctgcgcgg acgcgggcat 2341 cgccccgcgc gaggagatcc cccgcgacgt ggaggtggtg cgccgctccg gacagtccgg 2401 cacctacctc ttcgtcctca accacaccgg cgccgacgcc aaggtgccgc tggaggcgtc 2461 cggcaccgaa ctgctcggcg gcgcccgcgt ggccggccgg ctcgcggtgc cagccggtgg 2521 ggtccgcgtg gtccgcctcg acggctgagc cccggcgctc cggtacggcc gggccggtcg 2581 ccgagggccg gcggagggtc ggtgggtgcc ggcggaggac accgcaagag cagtgagaac 2641 accacgagaa caccacgaga gaaccggaag gaagggcaca gccatgcgca gacgcaccgt 2701 cctgcggctg ggagcagtcg ctctcgccgc ccccgccctg gccaccgccg cccccggcac 2761 ggccgcagcc gctccgcgcc tgcgcgtccg cggcgccgac gtctcctccc tcgccaaggg 2821 cgaggacctc ggcggcgtct accaccacgc cgacggccgc agggacgacg cggtacggat 2881 cctggcggga gccggggtca actggggccg tctgaaggtc tgggtggatc cggccgacgg 2941 ctaccacacc aggccccaca tcctgcggac ggcccggcgg ctgcacgcgg cgggcatgaa 3001 gctcctggtc gacttccact actccgacac ctgggccgac cccggcaagc agttcaagcc 3061 cgcggcctgg gaggacctcc acggagccgc gctggagcgg gcggtgcgcg accacaccgc 3121 cgacatcctg ggcgcgctgc gggcgcaggg cacaccggcg gccatggtcc agatcggcaa 3181 cgagatcaac ggcggcatgc tgtggcccga cggctcgacc gacgactggc cccgcctggc 3241 cggcctgctc acagccgggg ccgaggccgc ccgcgccgcc tcgcccggca tccgggtcgc 3301 cctccacctg gccgagggcg ggcggggcgc cgacacccgc tggtggttcg acaacgcggt 3361 ggcgcacggc gtgcccttcg acgccatcgg cctgtccttc tacggttact ggcacggcac 3421 gctggccgat ctccaggcca acctgaacga cgtctcggcc cgctaccgca gggacgtctt 3481 cgtcgcggag accgcctatc cgttccggct ggacagcgag gacttcctgg agaacatcat 3541 cgaccggccc tccgagctgg ttcccggcta ccccgcgacc cccgaggggc aggccgcctg 3601 gctgcgcgac atcacggcgg tcgtggccgc cgtaccgggc gggcggggac tggggctgtt 3661 ctggtgggag ccgacctgga ccgccgtgcc cggcaacggc tgggacccgg ccgacccggc 3721 ctccggcaac ggctgggaga accaggcgct cttcgactac gacagccgcg ccctcccggc 3781 gctggaggtc ctgggccgcg gctgacccgt acccgccgcc cgagggatcc gcgggcgggt 3841 acggcgaagg ggcggggccg ccgtggcggc cccgcccctt gctccgcgtt cctcgcgtcc 3901 cgccgaccgc gcaccgtgcg gtccggcggt cggcggcacg ctccccaccc cgcggggcgg 3961 tggtcacctc acgggggtga agtcccgtgc gccgaggaac tccgggcgcg ggatgggcgc 4021 cgcgaacggc tccaccgcgg tgttctccac gctgttgaag acgatgaaga cgttgctgcg 4081 cgggtagggg gtgatgttgt ccccggagcc gtgcatgcag ttgcagtcga accaggtcgc 4141 cgaaccgggc ttgcccgtga acagccggat gccgtgctcg ccggcgagcc gggtcagcgc 4201 ctcgtcggac ggcgtgcccg cgtcctgcat ctgcagggac ttcttgtagt tgtccttcgg 4261 ggtggccccc gcgcagccga ggaacgtcct gtgcgaacca ggcatgatca tcagggcgcc 4321 gttggtctcg tagttctcgg tcagggcgat cgagacggag accgtccgca tgttcggcag 4381 accgtcctcg gcgtgccagg tctcgaagtc ggagtgccag tagaaccccg atgccccgaa 4441 gcccggcttg acgttgatcc ggctctggtg gacgtacacg tccgagccca ggatctgacg 4501 ggcgcgtccc accacccgcg ggtccctcac caggttggcg aagacctcgc tgatcttgtg 4561 gacctcgaag acggagcgga tctcctggga cttcggctcc acgatcgaac gctcgtccgc 4621 gcggatcagc gggtccgaga ccagccggtt cagctcccgg ttgtagacct ccacctcatc 4681 gggggtgatg agctggtcga tcgccaggaa gccgtcccgg tcgtaggccg cgaggtccgc 4741 ggcctcgatc ggtcccggcg tgccgggggc ggaccacacc gtggggtcct gccgcggggt 4801 gatcacctcg gaggctcccc gggtcgggta gagatccgcg gtgcgttcgg gtgcggtggt 4861 catggttctg ccttcctctc ctcatcgtgc ggccctgttc ccgcgtgtgg ccgcttcgtc 4921 gcgggttctc tcgccagggc ctcccgtgtg gtctcggctg ccgctcgcac cggtccgtcc 4981 ggatcggccg gtgcggacgg tcagctctcg tccggttcgg tgagcagggg gtagacgccg 5041 ttctcgtcgt ggtcctcgcg gccggtgacc ggcgggttga agacgcagac gcaacggaag 5101 tccgtcttgg gacgaagtgt gtgcttctcg tgtccgtcca gcaagtacat ggtgccgggg 5161 gtgatccagt gcttctcgcc ggtctcgtcg ttggtgagct cggcctcgcc ctccacgcag 5221 aggacggcct ccacatggtt ggcgtaccac atcgaggtct ccgtgccggc gtagagcacg 5281 gtctcgtgca gcgagaagcc cacccgctcc ttcgcgagca cgatccgctt gctctcccag 5341 gtgccggagg cggacctgac gtggcggtcg gtgtcctcga tttcctgcag cgatcggacg 5401 atcacagtgc tgaggtgcct ttcctgtcag aggcccatcc gcggaaaaac tcgcgggatg 5461 ggccattcgg gtggtgcgtg cggcgaccgg acgcccccgg cgccggtcgg gcgccgggga 5521 cgggcggtgc cgcgtgtcag gcggtctcgc ggaccgcgcg ggccagggtg cgcaggccct 5581 cgtccagctc ctcgggggag atcgtcagcg ccgggagcag cttgacgacc tcgctctcgg 5641 ggccggaggt ctcgaccagc agccccagct cgaaggcgcg ggagcacacc cagccggcac 5701 gccccgcgtc ggggaacgcc agcccccaca ccagaccgcg gccccggaag ccggccaccc 5761 ccccgcggtg ctcgccggcg atcgcacaca gggcggcctc gacctgctcg ccgcgggcca 5821 gcgtctgctt ctccatctgc ccgtcggccc agtaggtatc cagggccgcc gccgcggtga 5881 cgaaggccgg gttgttgccg cggaaggtgc cgttgtgctc gccgggctcc cagacgtcca 5941 gctcgggccg gaacagggtc agcgccatcg gcagcccgta gccgctgatg gacttggaga 6001 ccgtgatgat gtcgggggtg atcccggcct cctcgaagga gaagaagccg ccggtgcggc 6061 cgcagcccat ctggatgtcg tcgacgatca gcagcatgtc ctggcgcttg cacaggtcgg 6121 ccagggcgcg cagccactcg gcccgggcga cgttgacgcc accctcgccc tgcacggtct 6181 ccacgatcac ggccgccggc cggttcaggc cggagccgga gtcctgcagc agccgctcga 6241 accacaggaa gtcctcgacc ttgccgtcga ggtagttgtc gaacggcatc ggggtgccgt 6301 gcaccagggg gacgccggcg ccggcgcgct tgaaggcgtt gccggtcacc gccagggagc 6361 ccagcgacat gccgtggaag gcgttggtga aggagacgat cgactcccgg cccttgacct 6421 tgcgggccag cttcagggcc gcctcgacgg cgttggtgcc ggtcgggccg gggaacatca 6481 ccttgtggtc caggccgcgc ggacgcagga ccacctcctg gaaggtctcc aggaaggccc 6541 gcttggcggt ggtggacatg tccaggccgt gggtgacgcc gtcgcgctcc aggtagtcca 6601 gcagggcgcg tttgagcacc gggttgttgt gcccgtagtt cagtgacccg gcgccggcga 6661 agaagtcgag gaacgcgtgg ccgtcctcgt cgtacatgta gctgccgcgc gccctgtcga 6721 agacggtggg ccagccgcgg cagtagctgc gcacctccga ttcgagggtc tggaagatgc 6781 tcaggtcggg ctgggtgatg gtcacagcga tctcctggga gatggattgc gagaggagtg 6841 agaggtctgg ggtgccgggg cgcggtgcgg cgcgccgcgc ggcggtcagc cgcctgcggc 6901 ggccggtgcg gtcgcggtgg aggccagggc tgggacgggc ccgatccggt acagcacctc 6961 gggctcgtgt ccctcctccg ggaacagcgc gccctcgaag aggacctcgc gccgcaccgg 7021 tgcgccgtgg cgctccgcgt aggaggtgaa cagtcggttg gaggcggtgt tgtcaggggt 7081 gatcgtcgtc tctatcccgt cgatgccaag ctcctcggcg gcacgggtgg tcagcccgtc 7141 gagcatcgcc gcggccaggc cgcgtccgcg ctgcccgtgg tcgacggcga cctgccagac 7201 gaccagggtc cgcgggtgcc gcggccggac gtagccggtt atgaaaccga ccggctcacc 7261 gtcgccgtcg cgcgccaccg ccgaggtggc ggcgaagtcg cggcaccaca ggaggtagct 7321 gtaggaggag ttgaggtcga gtacccggga gtcgcgcgcg atccgccaga tcgctgcgcc 7381 gtcctccacg cggggcgcgt cgagcttcag tccctccggc atttcgacgg tctttctgtg 7441 ggcacctgca tggtctgctt gtgcggcggt catgcaaatc caatttaccc agagcgaact 7501 caaatcacat cgaggacagg ggttacgcgg gcgcgctttc tgtgttatcg cgcgtgggtg 7561 cgcacgcgca cgaaagccgg tgcgttatgc ctggtatgcc ccctattttc cgggcaaaga 7621 ggaatcgatg ttgagtccgt cacagatcca taacgagcgc ggaacgtgtc cgaaatacgc 7681 ggttcgccga tatcgaatct tagtgtttaa ggaccgtctg agcgggcatg aggatatggg 7741 attctattca gatcaggtgc ccgtaaattc atcttcgatt catggaagat atcccagcga 7801 aaccggatcg tgaggttctt cagggaactc ggcggaagtc cccctccgcg gacaccggcc 7861 cgccggggcc cgtggcgtgg acggtgtagg agtcccgccc cgcgtcccgc agcccctccg 7921 catggccgta ctggcccacg aacctgtgct cgcccggcgg caccgcgcgc cccttccgca 7981 gcgtccagcg gtacaccagc gcgccgccct cctcgcggac ggtcacctcg aagtcgtccg 8041 ccggcagggt gctccagaag ccggtgtgcc gtacgccccc ggccggcgcg acgcgcagct 8101 ccacggtgag ggaggccagc cgctcgccgc agtgcaggac gacaccgctc tgcgcccagt 8161 gcgcgttgtt gccggggccc agcacccccc gggagcgcag ccggtcctcc cgcgggcccg 8221 gctcgccccc gccggcggac ggagcggcgg acggcggccc tccgtcccgg actccggctc 8281 ccgccggtgc ccgctccccc cacggctccc cgccgccggc cacccggtcg acggccagcc 8341 cgcccgcggc gagcacggcc accagcccgc cggcggcccc ggccatccgc ggccaggccc 8401 ggcggggacg cgggcggaca cggccggcct cctcccggga cccggccgga aggcgcgcgg 8461 acacccgggc ccacatgcgg gcccggtccg gacggtgccc gtcggcggcc accctgagcc 8521 gtgcgaccac atcggggcga tcggtcacca accgctccgt cccgcgggcc cggcgcgcag 8581 cgcccgtacg gtctcgtacg cgcgctccgg ccccgtccgg gccggcgcca gcatccgctc 8641 cagttcggcg atgccgcgcg aggtctggct cttgacggtg ccgaccgaga tgcccagggt 8701 gcgggcggtc tccttctccg acaggtcgaa ggcgtgccgc agcaccacac acgcccgctt 8761 gcgcagcggc agccgggcga gcgcgtcgcg cacgtccagc accgcgggca cgtcagggtc 8821 gtcgatgcgg tcgggccggt gcgaccagaa cagggcgatc cggcggcgct cgcgcaccag 8881 gctgcgctgc cgggtgcggg ccatgccggc caccacgctg cgcgcgtacg ccagcgggtg 8941 cccgtcggcg cgcacgctgt cccaccggcg ccacaccgcg acgagcgcgt cggcggcgag 9001 gtcgtcggct ccctcggagt ctcccagcag caggtaggcg aagcgggaca ggtcggcgta 9061 gtaccggtcg aagaaggcgt ggaactcttc ggtgggggcg tccacgcggc ctcctcaggg 9121 ctcgatggat cctgcgaagt gatgtgccac gaccccctgc ggctgcgtga gcgtagcagg 9181 ggactcgtac agtgcggcat atgagcgagc gcgggaattt ccacatccgg ggacgggtcc 9241 tgaccgggcc cggccccgac gacgtccggg acgagatgtg ggtcgtggac gggcggatca 9301 cctacgagcg gcccaccggg ccgctggaga cggccacggt cgagggctgg gtgctgcccg 9361 ggctggtgga cgcgcactgc cacgtcgggc tcgatgccca cggcgccgtc gacgacgcca 9421 ccagcgagaa gcaggcgctc accgaccgcg acgccgggac gctgctgatc cgggacgcgg 9481 gatcggccgc cgacacccgg tggatcgacg accgcgagga cctgccgcgc atcatccggg 9541 ccggccgcca catcgcacgc accaggcgct acatccgcaa ctacgcccac gagatcgagc 9601 ccggggacct ggcggcctac gtgcggggcg aggcgcggcg cggcgacggc tgggtcaagc 9661 tcgtcggcga ctggatagac cgcgagcagg gcgatctggc cccctgctgg ccgcgcggcg 9721 cggtggaggc cgccatcgcg gccgcccacg aggagggcgc gcgggtcacc gcccactgct 9781 tcgccgagga ctcgctgcgc gatctggtgg aggccgggat cgactgcgtc gagcacgcca 9841 ccggtctgac ggaggagacc atcccgctct tcgccgagcg gggcgtcgcc atcgtcccca 9901 ccctggtcaa catcgccacc ttcccccggc tcgccgaggg cggcgagaag aagttcccgc 9961 gctgggccga ccacatgcgg cggctccacg agcgccgcta cgacaccgtg cgcgcggcgt 10021 acgacgccgg catcccggtc ttcgtcggca cggacgccgg cggctcgctg ccgcacgggc 10081 tggtcgccga cgaggtcgcg gagctggtgg cggcgggcat cccgccggtg gacgccctgt 10141 cggcgaccac ctgggcggcc cgcgcctggc tggggcgccc ggggctggag gagggcgccg 10201 aggcggatct ggtggtgtac gaggcggatc cgcgggccga cgtacgggtg ctggccgcgc 10261 cgcgggcggt actgctcagg gggcgcgccg tgcggtgagg cgcgcggtga ggcgcgcggt 10321 gaggcatgcg gtgaggcgcg cggggtgtcc gcggtggagg agggcgtatg cccgccctgt 10381 ggagacgcgg tgcgataccc atgat //