LOCUS       NZ_FOBB01000010        24376 bp    DNA     linear   CON 22-OCT-2024
DEFINITION  Chitinophaga rupis strain DSM 21039, whole genome shotgun sequence.
ACCESSION   NZ_FOBB01000010
VERSION     NZ_FOBB01000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Chitinophaga rupis
  ORGANISM  Chitinophaga rupis
            Bacteria; Bacteroidota; Chitinophagia; Chitinophagales;
            Chitinophagaceae; Chitinophaga.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900109685.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 15:41:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,474
            CDSs (total)                      :: 6,410
            Genes (coding)                    :: 6,392
            CDSs (with protein)               :: 6,392
            Genes (RNA)                       :: 64
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1, 1 (16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 18
            CDSs (without protein)            :: 18
            Pseudo Genes (ambiguous residues) :: 0 of 18
            Pseudo Genes (frameshifted)       :: 4 of 18
            Pseudo Genes (incomplete)         :: 13 of 18
            Pseudo Genes (internal stop)      :: 2 of 18
            Pseudo Genes (multiple problems)  :: 1 of 18
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:12:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 66351
            Orig. end                         :: 90727
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOBB01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24376
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24376
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24376
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14376](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14376)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(338..2737)
                     /locus_tag="BMZ54_RS27615"
                     /old_locus_tag="SAMN04488505_11061"
     CDS             complement(338..2737)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF026255.5"
                     /locus_tag="BMZ54_RS27615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11061"
                     /product="outer membrane beta-barrel family protein"
                     /protein_id="WP_089919638.1"
                     /transl_table=11
                     /translation="MKLFFTSLFIILQFSTYAQSRISGQVSAAARPASFATVALLKAAD
                     SSLVKGMVCDSLGRFTLENVPYGSYLLAATQAGAGKTYSRGFIADSLHRQIMLDTLRLM
                     QQHTLKEVAVNAQKPYVEMQIDKLVLNVENSVMAHGNMIFDLLIHAPGMRQDQYGNIVM
                     MGKPGVQIWIDGRPSALTGESLSNWLKNQPADVVAKIEIITHPSSRYDAAGSAGIINIR
                     LKKNVQQGINGGAYTSLSMGKYPKASTGVNMNYRKNKLNIFGDYSYSYSESYNYRTLNT
                     VINNGSFIDYDNYWHPIGNYHYGKLGADYKPDAKTTIGMLLNGNISATNAITDANTAVY
                     SDPLEKRYLVAQADGKDRWNNLSYNFNILREIDSLGSTFNLDADLSRYDKTAYDNILNW
                     DRAGEKGQATQIAEIRSAMPVVIRVLSLKADYVKYFNKTFRIETGFKISRVSTDNDIRY
                     DSLLQQVWEPDLNRSNHFEYTENIQAVYATVVKEWKQLTLQAGLRAERTDATGNSLTLG
                     QKVQRRYAGFFPSLNVMKQINNNNQLTFSYSRRIDRPSYNSLNPFVVAIDPYNKSVGDP
                     YLNAAYSNTFELRHGFRQFLWTTLYYSHGSKGAISLIKQDSLTKIQTTTFANLGSSDYG
                     YLSVSISLPLTKWWQMDFNGGAGYAQYRSDIPGSRFTNGSWGAETGLDNTFTVFKNLKL
                     MISMFYNTAAPSGQELQRANYGGRLSASKPVLNKRGRISFTLQDPFNMQRYDADIYTNA
                     SAIRWINRWESRRVSLGFSWKFGRQQIKAARDRKNGMGDVERRVQL"
     misc_feature    complement(2740..2754)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.83"
                     /tool="antismash"
     gene            2923..3933
                     /locus_tag="BMZ54_RS27620"
                     /old_locus_tag="SAMN04488505_11062"
     CDS             2923..3933
                     /EC_number="2.7.13.3"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018305.5"
                     /locus_tag="BMZ54_RS27620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11062"
                     /product="sensor histidine kinase"
                     /protein_id="WP_162277686.1"
                     /transl_table=11
                     /translation="MTDQHRKILFSLLLLFGVTVMNLYLDIDIDLDLGIFMVSFTALKL
                     ASFYINYKWLHPRLLAKKRYAAWLLSVALLVIIVIALRYLVEEVLFLRLFGFRNYFQEL
                     TWTFYFKDNYLRFGVWVILASVVRFIENWYHLQRQQRELEKQHFTAEISFLKSQINPHF
                     LFNTLNSIYSLSYQQSEKAPAAILKLSEIMRYMLYDTEDKLVPLEKELQYLDNFVALQK
                     MRFKETIYADLLVEGNTQHQQIAPLLLIAFVENAFKHGELHDAADPVLIQVTLEPEQLQ
                     LYVQNRINAQGKDQTGGIGITNIKRRLELLYPGRHTLTVNNNGTHYICELKLKLA"
     gene            3937..4656
                     /locus_tag="BMZ54_RS27625"
                     /old_locus_tag="SAMN04488505_11063"
     CDS             3937..4656
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014219337.1"
                     /locus_tag="BMZ54_RS27625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11063"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_089919642.1"
                     /transl_table=11
                     /translation="MQKLRCIAIDDELLALDVITDYIHKTPFLELVYSTSQVLDALPLV
                     ESGGADLVFLDIQMPQLNGLQFMKIIHGKALVIFTTAYPQYALDGYEHDVLDYLLKPVA
                     YERFYKAAQKALSAIRPSQALTPYEKPAAELPNFIFVKTDNKMVKVQLSEILFVEGLKD
                     YIAIQTTAEKIITLQNMKRMEKILPAPRFVRVHKSYIVSLEKTDTIERNRIFIGDHVIP
                     IGDTYREPFFQLIEGRE"
     misc_feature    complement(4793..4806)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.41"
                     /tool="antismash"
     misc_feature    complement(4818..4831)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.96"
                     /tool="antismash"
     gene            4852..7260
                     /locus_tag="BMZ54_RS27630"
                     /old_locus_tag="SAMN04488505_11064"
     CDS             4852..7260
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024116.5"
                     /locus_tag="BMZ54_RS27630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11064"
                     /product="ABC transporter permease"
                     /protein_id="WP_089919645.1"
                     /transl_table=11
                     /translation="MIRNYFKVAWRNLIKDKQFTLLNLIGLSTGLACVLLIYLWVNDEL
                     HVDRFNEKDSQLYQVMKAAPNGDGTTAVWATAQGVLADELSKSFPEVEHAVAIRKEGET
                     GILSVGEKHMKAAWRFVSNDFLNVFSYRLIEGSKDKVLADKYGVLISDKLALKVFNTTH
                     NLTGKAFTWDAGGDFNGAYTISGVYEAPPSNATDQFDLAFNYRVYVDKEIGGVGDIYNW
                     GNNSVHTYLILKKGTDVNAFNNKIRDFTRSKIKNIPGSEYWSKWEGSLFVRKYSDGYLH
                     NNFENGKSIGGRIEYVRLFSIIAIFILVIACINFMNLSTAKASGRMKEVGIRKVIGAPR
                     RMLLLQYMGESMLMSFLSLAIAVLITFLLLPVFKEITGKQLSLSFNAGFVLSLLGIAVI
                     TGIIAGSYPALYLSGFRPTAVLKGKLHTSASESIIRKGLVVFQFTISVILIIAVIVVYQ
                     QMKLIQTKNLGYNKDNIIRFANVGKLQDNIQTFLAEARNIPGVINASSMQGDLLGHSGH
                     SGGGISWEGKDPNLGIEYFGVSGDLGYMEILGLKMATGRTFSDKFGADSSAVIFNEAAI
                     ARMGITDPVGKIVSLWGRKKQIIGVVKDFNFESLYKKVGPAFLEYSTRNKTILVKIKAG
                     TEQQTLAKLEQLYQHFNEGLPFEYKFLDEDYQTMYASEQKVSVLSRYFAVITIIISCLG
                     LFGLTAFTAQKRKKEIGIRKVVGASVNSITLMLTKDFLKLVMLAVLAAFPLAWWATNQW
                     LQSFAYRVNVDAAVFLVSGAAIIMLTLVTVSLQAIKAALADPVKSLRSE"
     gene            complement(7280..7810)
                     /locus_tag="BMZ54_RS27635"
                     /old_locus_tag="SAMN04488505_11065"
     CDS             complement(7280..7810)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BMZ54_RS27635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN04488505_11065"
                     /product="hypothetical protein"
                     /protein_id="WP_089919647.1"
                     /transl_table=11
                     /translation="MPFVQQHKTDLNGHATHHSLEEVRSEAVQEIMGKMPPWIIRIGIY
                     LVALLTAAALAGAWFFHYPEIVTAPVVVRQQLAAANIPAAAAWKVKAGQQVLIRLTAYP
                     KEEFGMLQGTVLSMSATETGTGFLVSIQLTHDRVTSAGKKIPPHPQLDGTAEIMAEDKS
                     IAARLFGKFWKMK"
     gene            complement(7815..10001)
                     /locus_tag="BMZ54_RS27640"
                     /old_locus_tag="SAMN04488505_11066"
     CDS             complement(7815..10001)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014220000.1"
                     /locus_tag="BMZ54_RS27640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11066"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_089919648.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2e-35, bitscore:
                     115.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFFFYKQMDAMDCGPTCLRMVARHYGRSYSLEYLRQQASITREG
                     VNLLGISEAAEKIGFRTNAVRITFEQLDEQVDLPCILHWNQQHFVVLPPQEYNRHKKGE
                     KILVADPGHGLVKVDKETFLDCWQGNSNTGTILMLEPTAAFYQKEAMQEAATGFRFLFN
                     YIKPYRKYIVQLFLSVLVASVLSLTLPFLTQSLVDYGINRNNTGFVYLVLVSQLLLFAG
                     STAIEMIRSWILLHMNSRINIHIISDFLIKLMKLPIRFFDTKMIGDIHQRIGDHTRIQN
                     FLTGTTLSTLFSFVNLLVFTVVLAVYSLKILLVFVLFSAAAIGWILFFLRRRKALDYKR
                     FQRMSENENILFELITGMQEIKLNNCETARRWEWEQVQAGLFKVNVKNLALGQYQQLGS
                     VFFHQLKNILISFITAREVMNGHLTLGMMLSVSYIIGQMNSPLDQLLTFIQSAQDAKMS
                     LDRLGEIHNRQEEERAGQEALPAGNGDIRLENVSFQYGPKQSPFVLKNINLVIPEGRVT
                     AIVGTSGSGKTTLLKLLLQFYEPGNGQVWVGNRRLQEISPRWWRRQCGNVMQDGFIFSG
                     SIAKNIAISDEKPDKHKLIHAAEAANIRDFIEELPLGYQTKIGNSGGGISAGQKQRIQI
                     ARAIYKDPRYLFFDEATSALDANNESIIMRNLEALFEGKTVVVIAHRLSTVKHADQIVV
                     LEKGEIVEVGTHATLTAQKGNYFELVKNQLELGG"
     gene            complement(10001..13129)
                     /locus_tag="BMZ54_RS27645"
                     /old_locus_tag="SAMN04488505_11067"
     CDS             complement(10001..13129)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="BMZ54_RS27645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11067"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_089919650.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.7e-173,
                     bitscore: 570.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.6e-08,
                     bitscore: 29.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2e-57, bitscore:
                     189.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALSHTGFFLLRSPLFPIKQYRRVLDNNLQALAQEFPVFLYALSV
                     ASRELLKELERYLADPAAFTPKKTEKLHRSLYKYWVRACTRSTPYGLFAGCTTGTVGET
                     TAWQLAPLAQARQHVRLDMDYYTRICHHIQRLPAVSETLTWYTNNSVYKSGDKFRYAEY
                     IIANNRRKYLLTAVADSVFIQKIIREACNGLTMQEMVQLIAAEDDSITAEEARAFVNEL
                     IDAQLLIAEIEPRITETDNLQALVNRLSSIEAATPVKDRLQQLQRLFQQQDFDQARLTT
                     IHDICNAAFSLDTPKDLLQVDLFKTAAACTISEKLLNGILQQVSELMALCQGYAKGGNT
                     ELAGFVSRFKERYESQEVPLNLVLDGETGIGYGSNLDSTIHAPFVEDIAGSGAENTMTT
                     VTWSPMQQLCLEKYEHYLRTGGSVTITGEELKKLGDPEQLPFARSSYLFGSLYANTAAD
                     ADNGVYTFALQSVGGPSAANLLGRFCSGDGHLAGHVQAALAAEEAAYPDVIFAEVVHFP
                     EARAANVLIRPPLRQYEIPYIGVSGVPSACQIPVSDLMVSVQDNEVVLRSKRLNKRVIP
                     RLSSAHNYSFNSLPVYKFLCDLQHQSLVSYLSWDWGVLAGRPSLPRVTYKNIVVCRASW
                     TITQKDLEPAGNKDTDPLQRFEKYRQQQGIPDKVLLSEADNELLLDLTQPIAVGILLDH
                     IKRTNTGKLKEFLAAEQHGMLRDEEHEVYAHELLVPLIYTSANTNILPMAAKQTTTGLT
                     RSFAPGSEWMYLKVYCGYRVAEGLLAGFFAEQVPLWQEDGLFEQFFFLRYGDPQPHIRL
                     RFLNKEHPANNDVLLHRIQTALQPYIRSGQVQKLQCDTYVREIERYTAAAMLQSEEMFF
                     ADSIAVLGIISLLEGAEGEEYRWKLALRGMHMMLDDFGLTLPERKQLLASLRTAFVTEF
                     GGAELLHKPLNDKYRKHQQQILSYLNAADDDRNDIAEAVDLFQQRSQTAQPLALQMRAD
                     CGSPDIYLRIIASHLHMFMNRLFIGKQRKHELVLYHFLEKYYLSQLALVAATK"
     aSDomain        complement(12428..12688)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BMZ54_RS27645_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.80E-09"
                     /identifier="RREFam001.1"
                     /label="BMZ54_RS27645"
                     /locus_tag="BMZ54_RS27645"
                     /protein_end="234"
                     /protein_start="147"
                     /score="29.2"
                     /tool="antismash"
                     /translation="NNSVYKSGDKFRYAEYIIANNRRKYLLTAVADSVFIQKIIREACN
                     GLTMQEMVQLIAAEDDSITAEEARAFVNELIDAQLLIAEIEP"
     gene            complement(13165..14376)
                     /locus_tag="BMZ54_RS27650"
                     /old_locus_tag="SAMN04488505_11068"
     CDS             complement(13165..14376)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="BMZ54_RS27650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11068"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_089919652.1"
                     /sec_met_domain="LANC_like (E-value: 3.2e-38, bitscore:
                     125.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNMIATQLRNIYNDLIPLLDQQKYDPDISGSLFKGPWGALLFMFY
                     YEQYADQEADNAVALLQKIYAGYTPHEGLNYSFCSGHTGPFWLLEHLSRHEFLEMDLDV
                     LTAEFISTTIEQSRFHLQWKNFDFLHGSIGMCNFLLPFSAREEVHTHLVFFADQLMAAS
                     KLTPLGRSLPIFYTHEQPAGTYVDAFSLAHGSCAALILLAKIYKAGIAEKTCRQLITEC
                     IPFILQHKIPVSGNGLHAMYPAILDGKQSSVNSRLAWCYGDLNVAWTLWYCGKVLDEKS
                     WMSEALEIMRYNTRRLTNETAGVIDNCICHGSSGIAAFYRKFWFETGEQSFYDCAAHWQ
                     QKAVELIAFSEEEGKHGIRVWQGKDKLWDYSWDLLDGGSGVGLSLLSHLQDHPLPWDEC
                     FLLS"
     misc_feature    14361..14375
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.31"
                     /tool="antismash"
     gene            complement(14476..14676)
                     /locus_tag="BMZ54_RS27655"
                     /old_locus_tag="SAMN04488505_11069"
     CDS             complement(14476..14676)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038153.1"
                     /locus_tag="BMZ54_RS27655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11069"
                     /product="class I lanthipeptide"
                     /protein_id="WP_089919654.1"
                     /transl_table=11
                     /translation="MKKKKVDLSKKLLFSKETIAQLTADQQAQVNGGAATLAATCTEDT
                     RLISSCRATSPGPGRPCCMIP"
     CDS_motif       complement(14584..14676)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKKKVDLSKKLLFSKETIAQLTADQQAQVN"
                     /locus_tag="BMZ54_RS27655_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14476..14583)
                     /prepeptide="core"
                     /locus_tag="BMZ54_RS27655_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-13.70"
                     /molecular_weight="3321.8"
                     /monoisotopic_mass="3319.6"
                     /core_sequence="GGAATLAATCTEDTRLISSCRATSPGPGRPCCMIP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKKKVDLSKKLLFSKETIAQLTADQQAQVN"
                     /leader_location="[14583:14676](-)"
                     /alternative_weights="3339.8"
                     /alternative_weights="3357.9"
                     /alternative_weights="3375.9"
                     /alternative_weights="3393.9"
     gene            complement(14757..14930)
                     /locus_tag="BMZ54_RS33015"
                     /old_locus_tag="SAMN04488505_11070"
     CDS             complement(14757..14930)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038153.1"
                     /locus_tag="BMZ54_RS33015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11070"
                     /product="class I lanthipeptide"
                     /protein_id="WP_156093030.1"
                     /transl_table=11
                     /translation="MKKKKIELSKKLLLKKETIVELNQQQQAKVAGGGPLTWWSACCVE
                     TDEVTCPADCVR"
     misc_feature    complement(15003..15012)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.48"
                     /tool="antismash"
     misc_feature    complement(15233..15247)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.1"
                     /tool="antismash"
     misc_feature    complement(15282..15295)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.29"
                     /tool="antismash"
     gene            15364..16248
                     /locus_tag="BMZ54_RS27660"
                     /old_locus_tag="SAMN04488505_11071"
     CDS             15364..16248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012787896.1"
                     /locus_tag="BMZ54_RS27660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11071"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_089919966.1"
                     /transl_table=11
                     /translation="MKLTITGYSTALFSTWYFVEELGLLFDAGDGITAALLQKARKIDN
                     VFISHADRDHLTGLLQFNQLNAREGFPKIFYPFNSSSFPAIETFSKNFDPHVSGTTWKG
                     IKENAHIQIKDDLYVQSIRNNHVPAEKDVFKSFGYQVYQVKNKLKKEYAGLSQEEILQR
                     IAEIGKERMTEQIRTNILTYSGDTPVDDPERWNNTKILIHEATFLGEQELNHANTHRNK
                     HSNLEQVLRMVSRLNIETLILGHFSSRYSNEEIDRSIRTLCDQLKIKIPVYRVLPGEVN
                     RNILAGEPINNTI"
     gene            complement(16245..16988)
                     /locus_tag="BMZ54_RS27665"
                     /old_locus_tag="SAMN04488505_11072"
     CDS             complement(16245..16988)
                     /NRPS_PKS="Domain: PKS_KR (12-134). E-value: 4e-10. Score:
                     31.8. Matches aSDomain:
                     nrpspksdomains_BMZ54_RS27665_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.5"
                     /locus_tag="BMZ54_RS27665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11072"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_089919655.1"
                     /sec_met_domain="adh_short_C2 (E-value: 1.4e-32, bitscore:
                     107.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTFANDALKGKTAIVVGGSRGIGKAIVERLAAAGAAVAINYVNS
                     AAAAEQIAEKIRQQDGKAIAIQADISQLPAIKTLFEKAEASLGKPDIVIANAASYIPAL
                     LSEATEEQYDAVFNTNAKGIFFVLQEAARRVKDGGRIIVTSTGGTQMYFSMNAIYLGSK
                     GAIEQFVRVLSRELGERNITVNAVSPGFTNTDLLPERDRAVAAAMSPFKRVGEPEDVAD
                     VTVFLASDAGRWITGQNIGAGGGVF"
     aSDomain        complement(16587..16952)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BMZ54_RS27665_PKS_KR.1"
                     /evalue="4.00E-10"
                     /label="BMZ54_RS27665_PKS_KR.1"
                     /locus_tag="BMZ54_RS27665"
                     /protein_end="134"
                     /protein_start="12"
                     /score="31.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TAIVVGGSRGIGKAIVERLAAAGAAVAINYVNSAAAAEQIAEKIR
                     QQDGKAIAIQADISQLPAIKTLFEKAEASLGKPDIVIANAASYIPALLSEATEEQYDAV
                     FNTNAKGIFFVLQEAARR"
     CDS_motif       complement(16878..16946)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BMZ54_RS27665_0001"
                     /evalue="4.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="BMZ54_RS27665"
                     /protein_end="37"
                     /protein_start="14"
                     /score="16.3"
                     /tool="antismash"
                     /translation="IVVGGSRGIGKAIVERLAAAGAA"
     gene            complement(17028..19589)
                     /locus_tag="BMZ54_RS27670"
                     /old_locus_tag="SAMN04488505_11073"
     CDS             complement(17028..19589)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018616402.1"
                     /locus_tag="BMZ54_RS27670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11073"
                     /product="GH116 family glycosyl hydrolase"
                     /protein_id="WP_089919657.1"
                     /transl_table=11
                     /translation="MKRPNRRRDFLKNIALGGLGAGLAPLTLHAESHRTERERTIKENP
                     SPQRRYNSAYTGEFNNMIAFPVGGIGTGMFCVEGTGAISHMSVRHVPEIYHEPAMFAAI
                     KIKGHAPRVLEGKVPDWKKFGQRDSGLGGRGGATWGLPRFAAAEFEARFPFGKVSMKDE
                     SMPLSVSLQAWNPFIPNDENHSGLPVGGLEYTFKNTGSSTQELIFSYHSRNFMQQQDAA
                     NSIGAISNGFILSSAGTQQAPSKEGHFAIFTNEGATVVDHCWFRGAWFDPLSMVWNTVS
                     DGQLRNTPPVNADAPGASLYVPFTLAPGQQKTIRLMMAWYVPHSTLRIGEFEKEDEADH
                     SEARFYRPWYSNRFNSIQNIADYWKTNYETLQQKSLLFQKAFYNSTLPPEVLEAIAANL
                     TILKSTTVMRPYEGRFWAWEGSGDSWGSCHGSCTHVWNYAQAVPHLFPVLERSLRETEF
                     NEDQNEAGHQVFRANMPITKVKHTFHSAADGQLGGIMKVYREWRIMGDDQWLQTMYPAV
                     KKSLDYCIKTWDPRKKGVIEEPHHNTYDIEFWGATGMCTSFYLGALRAFTEMSEHLHQD
                     AAAYKDLYNKGKQQLETELYNGEFFIQKIQWTGLNAPDPVKAQSFSTGYSPEALELLKK
                     EGPKYQYGAGCLSDGVLGAWIARVCGLDDIIDAGKIKSHLAAVYKYNLRQDLSSHANPQ
                     RPTYALGKEGGLLLCSWPKGGKLSLPFVYSNEVWTGIEYQVASHLIFMGEVEKGLDIVR
                     TCRDRYNGKVRNPFNEYECGHWYARAMSSYGLLQALTGVRYDAVERTLYVDSKVGDFTS
                     FLSTESGFGNVSQKNGKVRFNAVSGKLDIKKIVVSGRVQAV"
     misc_feature    19681..19697
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 26.78"
                     /tool="antismash"
     gene            complement(19779..20762)
                     /locus_tag="BMZ54_RS27675"
                     /old_locus_tag="SAMN04488505_11074"
     CDS             complement(19779..20762)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012955.5"
                     /locus_tag="BMZ54_RS27675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11074"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_089919659.1"
                     /transl_table=11
                     /translation="MERRALIKNGLLLGLSAALPLAPLAAMIKRRKPNAYTGFHEFELG
                     KLKLKVVTDGHILFKKVQPGFAPGFPAAAVEKLLNENFLPDSVDLGINVLIINTGSKQI
                     LVDTGCGSSLGENSGWLLKNLPLAGIHPQDITDVVLSHAHPDHLGGLLDKDGNMPFKNA
                     DIYIAQKEYDFWMVAQPDFSKSKMDDQELKALVIRVAQETLTKTKPRLHLFEDGDTLFD
                     CIRLNLAPGHTPGHTVTTIFSEGQELVHVADLVHSPVLVFAHPEWGFEGDTNFELAAAT
                     RRKVLGELAANRKQVFSYHLPWPGLGHVRKKEDGFEWVQTGFALPD"
     misc_feature    20762..20771
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     gene            20875..21237
                     /locus_tag="BMZ54_RS27680"
                     /old_locus_tag="SAMN04488505_11075"
     CDS             20875..21237
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012792863.1"
                     /locus_tag="BMZ54_RS27680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11075"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_089919661.1"
                     /transl_table=11
                     /translation="MTKTNLKDKQASCAVDYGFQRIGGKYKCRLIWYIHERKVVRYGEL
                     KRMVKGITPKMLTQTLRELEEDGLVIRKAYHEVPPKVEYTLTPIAEELIPFINHVKQWA
                     ERRMEELPDPIEQIAC"
     gene            complement(21234..21899)
                     /locus_tag="BMZ54_RS27685"
                     /old_locus_tag="SAMN04488505_11076"
     CDS             complement(21234..21899)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012334.5"
                     /locus_tag="BMZ54_RS27685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11076"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_089919663.1"
                     /transl_table=11
                     /translation="MNRLNKTAVVTGISSGIGLALTKKLLNEGYNVIGTTRSGVLKELS
                     HPDLQIIALEATDRQSSQQAVERILTLTGGIDLLINNAGAAPDVFAVEPEYQSFTQTLN
                     TNITGAVFFTEPLLEHINEGGQIIFISSNMGLPENAAPNGPGYRLSKAAINMYAAMLAT
                     RLADSSIRVMPVHPGWVQTKLGGDQAPLTPEQSAEGIYQGILTGTQSGKLWDITAAVN"
     gene            complement(21921..22388)
                     /locus_tag="BMZ54_RS27690"
                     /old_locus_tag="SAMN04488505_11077"
     CDS             complement(21921..22388)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012794794.1"
                     /locus_tag="BMZ54_RS27690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11077"
                     /product="ester cyclase"
                     /protein_id="WP_089919666.1"
                     /sec_met_domain="PF07366 (E-value: 6.6e-22, bitscore: 71.6,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQHEQPEMVKALTAAERNAITVFYSAWKKKQPELLDEVCTPDW
                     QDIPLGPGQAEGPKGLQDIIRGFSATFPDVEIVIHEIYGTYERAGVRASFVFTHNNELM
                     GIPATGKKVALALHEFHHLKDGRLTHTWHLEDWFGLLLQSGVWAAKGLGGN"
     misc_feature    22428..22448
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.05"
                     /tool="antismash"
     misc_feature    22452..22465
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.64"
                     /tool="antismash"
     gene            complement(22535..23704)
                     /locus_tag="BMZ54_RS27695"
                     /old_locus_tag="SAMN04488505_11078"
     CDS             complement(22535..23704)
                     /GO_function="GO:0016209 - antioxidant activity [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF020123.5"
                     /locus_tag="BMZ54_RS27695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_11078"
                     /product="TlpA disulfide reductase family protein"
                     /protein_id="WP_089919668.1"
                     /transl_table=11
                     /translation="MKFNLRSTPLILLLLVFTYSGYAQSKPFTITGLIKGLPDGAKVEL
                     VPGATHQDEAPVATATVSQGKFELKGEVPEPRLFYIRLAEPRGYYSLMVQSGEISLTGD
                     ARLSGNGDNKFYEFEHMLVKGSDAHTQFLQKKAPREMLDSVYMANREASKEISEKVNAA
                     YKNKDTVLLKSLKETEAYKQMDARESAFFKLVTATFEKIIRDNKDTWWGPFLALDLYNY
                     FTPKDKPVYEQFSQEAKDSYYGKLLYEQLNPKGFAGQPAPLLDLKASTSIPTDIASLTK
                     GHKYVLVDFWASWCGPCRRAIPAMKSSYADLQAKGVQIVSVSIDKKEADWLKAQKEEKL
                     PWPSFLDKGKTANAWKIRAIPAMFLLDEKGIVVGENLTLEEIQAKMKEN"
ORIGIN
        1 ccgaatgtgt tcttgccagc cggtattccg gtgaatcatt ttcctcctga acataaaaag
       61 cagtcaggtg ggattcttcc aggtgaggat atttgtttgc aaccaggtcc cttacggtta
      121 cggtgctctc cgggtaacgt gcctgcagct tgtctataat ttcctgttgc agccgtatgc
      181 tgttggaagc tttactacgg gcgcttgaga tgacgcttaa tattttcttc atgttgtaaa
      241 cagttttgct aattgtgttt acaaaattag gttagcctgg tacttgcagg cgcaaggtat
      301 accaaaggtt agtgctaacc tttgggttag ctacctgtta tagctgtact cttctttcta
      361 catcccccat cccgttcttc cggtccctgg cggctttgat ctgctgccgc ccaaacttcc
      421 aggaaaagcc taagcttacg cggcggctct cccagcggtt tatccaacgg atggcagagg
      481 cattcgtgta tatatccgca tcatagcgct gcatattaaa tggatcctgc agcgtaaagc
      541 tgatccgccc tcttttattg agcaccggct tactggcgct caaacgcccg ccatagttag
      601 cgcgctgcag ctcctgacca gaaggcgccg cagtgttata gaacatactg atcatcagct
      661 tcaggttttt aaatacggtg aacgtgttat ccaaaccggt ttctgcgccc cagctgccat
      721 tggtgaaccg gctgcctgga atatccgaac ggtattgcgc gtaacctgca ccaccgttaa
      781 aatccatctg ccaccatttg gtaagcggca aactaatact taccgataga tacccgtaat
      841 cgctgctgcc caggttagca aaggtggtgg tttgtatttt cgtaaggcta tcctgcttaa
      901 taaggctaat agcgcctttg ctgccatggc tgtaatacag ggtggtccac aggaattgcc
      961 ggaaaccatg ccgcagctca aaagtattac tgtaagcagc attcaggtaa gggtcgccca
     1021 cgcttttatt atagggatca atggctacca caaaggggtt cagggaattg tacgaaggcc
     1081 ggtctatacg cctggaatag ctgaaggtaa gctgattatt attgtttatt tgtttcatca
     1141 cattcagcga tggaaaaaag ccggcatacc tgcgttgcac cttttgcccc agcgtcaggg
     1201 aattgccggt tgcatctgtt ctttcggcac gcagtcctgc ctgcagggtt aattgcttcc
     1261 actcctttac cacggttgca tacactgcct gaatgttttc cgtatattca aaatggttag
     1321 atcggttcag gtccggctcc caaacctgct gcagcaaaga atcatagcgg atatcgttat
     1381 cggtgctcac cctgctgatc ttaaaaccgg tttctatgcg gaaggtttta ttaaagtact
     1441 ttacataatc ggcctttagc gatagcaccc ttatgactac cggcatggcg ctccggatct
     1501 ctgcgatctg tgtagcctgg cctttttcac cggcacggtc ccagttcagg atattatcgt
     1561 aggctgtttt atcatagcgg gaaaggtcag catccaggtt aaaggtgctg cccaggctat
     1621 ctatctcacg caaaatatta aagttgtaag agaggttgtt ccagcggtct tttccatctg
     1681 cctgcgccac caggtagcgc ttttccaaag gatcgctgta taccgctgta ttggcatctg
     1741 taatggcgtt ggtagcactg atgttaccat tcagcaacat accgatcgtt gttttggcgt
     1801 caggcttata atcagcgccc agcttcccgt aatgatagtt gcctatggga tgccagtagt
     1861 tatcgtaatc aataaaagag ccgttgttga tcactgtgtt cagcgtacgg taattgtacg
     1921 attctgaata cgaataacta tagtcgccga aaatgttcag cttatttttc cggtagttca
     1981 tattaacccc tgtggaagcc tttggatatt tacccatgga cagggaagta tatgcgcccc
     2041 cgtttatgcc ctgctgcaca ttcttcttca ggcgtatgtt aataataccc gcgctgccgg
     2101 ccgcatcata cctggacgaa ggatgcgtga tgatctcaat tttagcaacc acatctgccg
     2161 gctggttctt tagccagttg gaaaggcttt cgccggtaag tgcagagggg cggccgtcta
     2221 tccagatctg cacaccgggc ttacccatca tcactatatt cccatactga tcctgtcgca
     2281 tgcccggggc atggatcagc aggtcaaaga tcatattgcc atgcgccatt acgctattct
     2341 ccacattcag caccagctta tctatctgca tttccacata aggcttttgt gcatttacag
     2401 ctacctcttt taaagtatgc tgctgcatca gccgcaaggt atccagcatt atttggcggt
     2461 gcaggctatc ggcaataaag cccctgctat aggttttgcc ggcgcctgct tgtgttgcag
     2521 ccagcagata gctgccataa ggcacatttt ccagcgtaaa acggcccagg ctatcgcata
     2581 ccattccttt aaccaatgag ctgtctgccg ctttcagcaa agccacggta gcaaaggatg
     2641 ccggcctggc agcagcagat acctgcccgg aaatacggga ttgggcatac gtgctaaatt
     2701 gtaaaatgat gaacagggag gtaaaaaaca gcttcataaa tcttaaattg agaccctgca
     2761 aagatgcctg caaacggccg ggcctgcggc ttcaattata ccaaccatct cccgggcccg
     2821 accaaccagg gccggcccgt tggtcggacg gaaagggtag tttgtcgaag aaaggccagg
     2881 gccaggcagc ttcccggtaa ctttgggatc aatcaccgta ttatgacaga tcagcataga
     2941 aaaatacttt tcagcttact acttttgttc ggggtaacgg tcatgaacct ttacctggac
     3001 attgatattg atctggacct tggcattttc atggtctctt ttacggcgct gaaactagcc
     3061 agcttttata tcaactataa atggctgcat cccaggctgc tggcaaaaaa aagatatgct
     3121 gcatggctgc tgagcgtggc cctgctggtg atcatcgtca tcgcgctccg ctacctggtg
     3181 gaagaggtat tgttcctgcg cctgtttggg ttcaggaatt attttcagga gcttacctgg
     3241 accttttatt tcaaagacaa ttatctgcgt tttggcgtat gggttatact ggccagcgtg
     3301 gtacgcttta tagaaaactg gtaccacctg cagcggcagc aaagagagct ggaaaaacaa
     3361 catttcactg cggagatctc cttcctgaaa tcgcagatca acccgcattt cctgttcaat
     3421 accttaaaca gcatttactc cctctcctac cagcagtcag aaaaagcgcc ggccgccatc
     3481 ctgaagctat cggagatcat gcggtatatg ctgtatgata cggaggacaa gcttgtgccg
     3541 ctggaaaagg agctgcaata tctggacaat tttgtggcgt tacagaaaat gcgttttaaa
     3601 gaaaccatct atgccgatct gctggtggaa ggcaatacgc aacaccagca gatagcgccg
     3661 ctgctgctga tcgcttttgt ggaaaacgcc tttaaacatg gtgagctgca tgatgccgct
     3721 gatcctgtgc ttatacaggt aacccttgag ccggaacagc tgcagctgta tgtgcagaac
     3781 cgcataaatg cgcaggggaa agatcaaacg ggcggtattg gcattaccaa catcaaacgc
     3841 aggctggagc tgttgtaccc cgggcggcac acgttaacgg tgaataataa cggaacgcat
     3901 tacatttgtg aacttaagct gaaactggcc tagcccatgc aaaaattacg ctgtattgct
     3961 atagatgatg aactgctggc actggatgtg ataaccgatt acattcacaa aacccctttc
     4021 ctggagctgg tatacagcac cagccaggtg ctggatgcct tacccctggt ggaaagcggc
     4081 ggggccgacc tggtgttcct ggacattcaa atgccccagc tgaacggcct gcagttcatg
     4141 aagatcattc atggcaaagc ccttgtgata ttcactaccg cctacccgca gtatgcgctg
     4201 gacggttatg agcatgatgt gctggattac ctgctgaaac ctgttgccta cgaacgtttt
     4261 tataaagcag cgcaaaaagc gctcagcgcc atacgcccca gccaggccct tacaccctat
     4321 gaaaagcccg cggcagaact gcctaatttt attttcgtga aaacggataa taaaatggta
     4381 aaggtgcagc tctcagagat cctgtttgtg gagggcctga aggattatat tgccatacaa
     4441 accactgctg aaaagatcat taccctgcag aatatgaaac gcatggagaa gatactgccg
     4501 gcgcccaggt ttgtgcgggt gcataaatcc tatattgttt ccctggaaaa aaccgatact
     4561 attgaacgga accgcatctt catcggcgat catgtaatac cgatcggcga tacttaccgg
     4621 gagcctttct tccagcttat tgagggcagg gaataactat tatttcatgg gcagtttcat
     4681 cagcctgata cggtgatgcg ccagctactc ataccccagt tgtataaaac tgaacatgcc
     4741 gtgtatcata aacggacacc tacttaattt tgtaaaatca taaccagctg gttattaata
     4801 attatagaag atggcatttt ttttatagaa taaccatcaa atcccacctg aatgataaga
     4861 aattacttta aagttgcctg gcgtaatctc ataaaagaca aacagtttac cctgcttaac
     4921 ttaataggct tgtcaacagg gctggcctgt gtgctgctga tatatctgtg ggtaaatgat
     4981 gaactgcatg tggaccggtt taatgaaaag gacagccagc tataccaggt aatgaaagcg
     5041 gctcccaacg gagatggcac cactgctgta tgggcaactg cacaaggcgt tttagccgat
     5101 gaactatcca aatcattccc tgaagttgag catgcggttg ccataagaaa agaaggtgag
     5161 acggggatcc tttcagttgg tgaaaaacat atgaaagcag catggcgttt tgtgagcaat
     5221 gatttcctga acgtattttc ctaccgcctt attgagggga gtaaagacaa ggtgctggct
     5281 gataaatacg gggtgctgat ctcagataaa cttgctttga aagtatttaa caccactcat
     5341 aacctgaccg gcaaagcctt cacctgggat gccggcgggg attttaatgg cgcttacacc
     5401 attagcggcg tatatgaagc gcctccatcc aatgcaacgg accagtttga tcttgcattt
     5461 aactataggg tatatgttga caaagagatt ggtggggtgg gcgatattta taactgggga
     5521 aataatagtg tgcatactta tttgatcctg aaaaaaggta cggatgtaaa tgccttcaac
     5581 aataagatca gggattttac aagatcaaaa ataaagaaca tacctggttc tgaatattgg
     5641 tcaaaatggg aaggaagcct atttgtccgg aaatattcag acgggtacct gcacaataat
     5701 tttgaaaatg gaaaatctat tggcggcaga attgagtatg tacgcctttt ttccatcatt
     5761 gctattttca tactggtgat cgcatgtatt aatttcatga acctttctac ggcaaaagct
     5821 tccggaagaa tgaaggaagt gggtataaga aaagtgatcg gcgcacccag gagaatgctg
     5881 ctcctgcaat acatgggaga atctatgtta atgtctttcc tgtcgctggc aattgccgta
     5941 ttaataacct ttttattact tccggttttt aaagaaatta ccggaaaaca gctgtcactc
     6001 agcttcaacg cgggctttgt cctttcacta ttaggcattg cggttattac cggtattatt
     6061 gccggcagct atccggcgct ttatctctcc ggcttcaggc ccactgctgt gctgaaaggg
     6121 aagctgcata cttccgcgag tgaatccatc ataaggaaag gtttggttgt ttttcaattt
     6181 actatttcag tcatactcat tattgcggtt attgttgtat atcagcaaat gaagctgata
     6241 caaacaaaaa atcttggcta taataaagat aatatcatcc ggtttgccaa tgttgggaaa
     6301 ctgcaggata atattcagac cttccttgct gaagccagga atattcccgg tgttataaat
     6361 gcctccagta tgcaaggtga tcttttaggc cattcaggcc acagcggcgg cggcatttca
     6421 tgggaaggga aagatcccaa tttaggtata gaatattttg gggttagcgg cgatcttgga
     6481 tatatggaga tactgggatt aaaaatggct acaggccgta ctttttcgga caaatttggt
     6541 gcggatagtt ctgctgttat tttcaatgaa gcagccattg ccagaatggg cattacagat
     6601 cctgttggca aaatagtttc actctggggg cgtaaaaaac agatcattgg agttgtaaag
     6661 gattttaatt ttgaatctct ctataaaaaa gtaggtcctg cattcctgga atattccacc
     6721 cgcaacaaaa ctatcctggt aaaaataaag gccggtactg aacagcaaac cctggcaaag
     6781 ctggaacaac tctaccagca ttttaatgaa gggcttccat ttgagtataa gttcctggat
     6841 gaggattacc agactatgta tgcgtcagaa caaaaagtat ccgtactgtc ccggtatttt
     6901 gccgttataa ctatcatcat ttcctgtctg ggcctttttg gtcttactgc atttaccgca
     6961 caaaaaagaa aaaaagagat tggtatccgc aaagtggtag gcgcttctgt aaacagtatt
     7021 acgttaatgc tgacaaaaga ctttttaaaa cttgtaatgc ttgccgtact tgcagctttt
     7081 ccgctggcct ggtgggcaac taatcaatgg ctgcaaagct ttgcctatcg tgtaaacgta
     7141 gatgccgccg tattcctggt ttcgggcgcc gctattatca tgcttacttt ggtaaccgtg
     7201 agcctgcagg ccatcaaagc agcattggcc gaccccgtaa agtcgttgcg gagtgaatga
     7261 tggaccatcc gggatccttt tatttcattt tccagaactt accaaataac cgcgctgcta
     7321 tgcttttatc ctcagccata atttcggcgg ttccatccag ctgcggatga ggggggatct
     7381 ttttaccagc gctggtaacc cggtcatgcg ttaactgtat acttaccagg aagcctgtac
     7441 ccgtttcagt ggcgctcata ctcagcacag taccctgcag cattccaaat tcctctttcg
     7501 gataggcagt aagccggatc aatacctgct gaccggcttt tactttccag gcagcggcgg
     7561 ccggaatgtt agctgctgcc agctgttgcc gcaccaccac aggcgccgtt acaatctccg
     7621 ggtaatgaaa gaaccatgcg cctgccaatg ctgctgctgt tagcagcgct accaggtaaa
     7681 taccaatgcg gatgatccag ggcggcattt tccccatgat ctcctgcaca gcttcactcc
     7741 gcacctcttc cagggagtga tgagtggcat ggccatttaa atcggtttta tgttgctgaa
     7801 caaacggcat atgatcatcc tcccagctcc agctgatttt ttaccagttc aaaataattt
     7861 cctttttgtg cggtaagcgt ggcatgcgta cccacttcta cgatctctcc tttttccagc
     7921 accacgatct ggtctgcatg ttttaccgtg cttagccggt gtgcgatcac caccacagtt
     7981 ttgccttcaa aaagcgcttc caggttacgc ataataatgc tttcattgtt ggcatccagc
     8041 gcgctggtag cttcatcaaa aaataagtag cggggatctt tataaatggc gcgcgcaatt
     8101 tgtatacgct gtttttgtcc tgcgctgatg ccgccacctg aatttccgat cttagtctgg
     8161 tagcccaatg gcagctcctc tataaaatcg cgtatgttgg ctgcttccgc tgcatgtatt
     8221 aatttatgct tgtcgggctt ttcatcactg atagcaatgt tctttgcaat ggagcctgaa
     8281 aaaataaaac cgtcctgcat tacattgcca cattgccgcc gccaccagcg gggcgatatt
     8341 tcctgtaagc gccggttgcc tacccatacc tgaccgttgc ccggctcata gaattgcagc
     8401 agtaatttta acagggtagt tttaccgctg ccgctggtgc ccacaatagc ggtcaccctt
     8461 ccttccggta tcaccaggtt aatgttcttt aaaacaaaag gagattgttt aggcccatat
     8521 tggaaggata cattttccag gcgtatatcg ccattgcctg ctggcagcgc ctcctggccg
     8581 gcccgctctt cctcctgccg gttatggatc tcgcctaaac ggtccaggct catttttgca
     8641 tcctgggcgg attgtataaa ggttaacagc tgatccaggg ggctgttcat ctgtcctatg
     8701 atgtagctca cagataacat catgcccagc gtaaggtgcc cgttcatgac ttcccgggcg
     8761 gttataaaag agatcaggat atttttcagc tggtgaaaga aaaccgaacc aagctgctgg
     8821 tattgcccta atgccaggtt ctttacattc accttaaaaa gccccgcctg tacctgttcc
     8881 cattcccagc gccgggctgt ttcgcagtta tttaatttga tctcctgcat gccggtgatg
     8941 agctcaaata aaatattctc gttctcgctc atgcgctgaa agcgtttata gtccagcgct
     9001 ttacggcgcc gcaggaaaaa gaggatccag ccaatagcag cggcgctgaa cagtacaaat
     9061 accagcaaga tcttcaggct gtacacggcc agcactacgg taaacaccaa caggttcaca
     9121 aaagaaaaaa gggtggacag tgtggtaccg gtcaggaagt tctgtatgcg ggtatgatcg
     9181 ccgatgcgct gatgaatgtc gccgatcatt tttgtatcaa aaaaacggat cggtaatttc
     9241 atcagcttga tcaggaaatc ggaaatgatg tggatgttga tccggctgtt catatgcagc
     9301 aggatccagc tgcggatcat ttcaatggcg gtggagccgg caaataacaa cagctgggat
     9361 accagcacca ggtatacaaa gcccgtgttg ttgcggttaa tgccatagtc taccaggctt
     9421 tgggtaagaa aaggtaatgt gagcgacagc acactggcca ccagcacact taaaaatagc
     9481 tggacaatat atttgcgata gggttttatg taattgaaca gaaaacggaa accggtggct
     9541 gcttcctgca ttgcttcctt ttgataaaag gccgcggtag gttccagcat taatatggtg
     9601 ccggtattgc tattaccctg ccagcagtcc aggaaagttt ccttatccac ctttaccagt
     9661 ccatgccccg ggtctgccac caggatcttc tccccctttt tatgccggtt atattcctgc
     9721 gggggcagca ctacaaaatg ctgctggttc caatggagta tgcagggcag gtctacctgc
     9781 tcatccagct gctcaaaggt gatacgcacc gcattggtac ggaagccaat tttttcagct
     9841 gcctcgctaa tgcccagcag gttcactcct tcccgggtaa tgcttgcctg ctgccgcagg
     9901 tattccagcg agtagctgcg gccatagtgg cgggctacca tgcgcaggca ggtaggtccg
     9961 caatccatag cgtccatctg tttatagaaa aagaatccca ttacttggta gcggctacca
    10021 gcgccagttg tgataaataa tatttttcca ggaaatgata cagcaccagc tcatgcttcc
    10081 gttgcttgcc aatgaataag cggttcatga acatatgcaa atggctggca ataatgcgca
    10141 ggtatatgtc cggcgagccg caatccgcgc gcatctgtaa agccaatggc tgtgcagtct
    10201 gtgaacgctg ctgaaaaaga tccactgctt cggcaatatc attgcggtca tcatcggcag
    10261 cattcaggta agacaatatc tgctgctggt gtttgcggta tttatcattg agcggtttat
    10321 gcaacagctc tgctccgcca aattccgtaa caaaagctgt tcttaaggaa gccagcaatt
    10381 gtttcctttc cggcagggtt aacccaaaat catccagcat catatgcata ccccgcaggg
    10441 ccagcttcca gcggtactcc tctccctcag cgccttccag caaactgata atacctagta
    10501 ccgctatgct gtctgcaaag aacatttctt cgctttgcag catggcagca gcggtatagc
    10561 gctctatttc acgtacataa gtatcacatt gcagcttttg tacctggcct gaccttatat
    10621 acggctgcag cgctgtttgt atgcggtgta aaagcacgtc gttattagca ggatgctcct
    10681 tattcagaaa tcttaagcgg atatgcggct ggggatcgcc ataccgcaga aaaaagaact
    10741 gttcaaacag cccgtcttcc tgccataggg gtacctgctc cgcaaagaaa ccagccagca
    10801 gtccttctgc cacgcggtaa ccgcaataca ccttcaggta catccattcg ctgcccgggg
    10861 caaaactccg tgttaaaccg gttgttgtct gctttgccgc cattggtaag atattggtgt
    10921 tagcggaagt atagatcaaa ggcaccagca gctcatgtgc atatacctca tgctcctcat
    10981 cccgcagcat accgtgctgc tctgctgcca ggaactcttt taactttccc gtattggtgc
    11041 gcttaatatg atccagcaaa ataccaaccg ctataggttg tgtaagatcc agcaacagct
    11101 cattatctgc ttcagataat aataccttat caggaatgcc ctgttgctgc cggtactttt
    11161 caaaacgctg cagcggatcc gtatccttat taccggctgg ttccaggtct ttttgcgtta
    11221 tggtccagct ggcgcggcat acaacaatat ttttgtaggt tactctcggc aggctgggac
    11281 ggccggccaa cacaccccaa tcccaggaaa ggtatgatac cagcgactgg tgctgcagat
    11341 cgcacaggaa tttataaacc ggtaaactat taaagctata gttatgggct gagctaaggc
    11401 ggggaataac gcgcttattc aggcgcttac tcctcagcac cacttcatta tcctgtacag
    11461 ataccatgag gtctgatacc ggtatctggc aggctgacgg tacaccggac acacctatgt
    11521 agggaatttc atattgccgt aaaggcggcc gtatcagcac attggcggca cgggcttcgg
    11581 gaaagtgcac cacttctgca aaaataacat cggggtatgc ggcttcctct gctgccagcg
    11641 cggcctgtac atggccggct aaatgcccgt ccccgctgca aaagcggcct aaaaggttag
    11701 cagcagaagg gccgcccaca gactgtaacg caaaggtata aacgccgtta tccgcatctg
    11761 cagctgtatt ggcatataaa gagccaaaca ggtagctgct gcgtgcaaag ggcagctgtt
    11821 ccggatcgcc taacttctta agctcttcgc cggtaatggt aacggagccg cctgtacgca
    11881 ggtagtgctc atacttttcc aggcacagct gttgcatggg cgaccaggtt actgtggtca
    11941 tagtattttc tgcaccactg ccggctatat cttctacaaa gggcgcatga atagtactgt
    12001 caaggttact gccataacca atgccggttt caccatccag taccaggtta agcggcactt
    12061 cctgcgattc atagcgttct ttgaaacggc ttacaaaacc ggccagctct gtgttcccac
    12121 cttttgcata tccctggcaa agggccatta gctcacttac ctgctgcagt ataccgttta
    12181 agagtttttc gctgatagtg caggcagcag cggttttaaa caggtcaacc tgcagcaggt
    12241 ctttcggtgt atccaaggaa aaagcggcat tacagatatc atgaatagtg gttaaacgtg
    12301 cctggtcaaa atcctgttgc tgaaacaggc gctgcagctg ctgcaggcgg tcttttacag
    12361 gggttgctgc ttcaatggat gaaaggcggt ttacaagggc ctgcaggtta tctgtttctg
    12421 taatgcgggg ttcaatttct gcgatcagta gctgcgcatc tatcagctca tttacaaaag
    12481 cacgtgcctc ttctgcagta atggaatcat cctcagcggc tatcagctgc accatttcct
    12541 gcatagttaa accattgcat gcttcgcgga tgatcttttg tataaatacg gaatcggcca
    12601 ctgctgttaa caggtactta cgccggttat tggcaataat atattccgca tacctgaact
    12661 tatccccgct tttgtatacg ctgttattgg tataccaggt aagcgtttca cttactgctg
    12721 gcaggcgttg aatatgatga cagatcctgg tatagtaatc catatccagg cgcacatgct
    12781 gccgtgcctg cgccagtggc gccagctgcc aggcagttgt ttcgcctacc gttccggtag
    12841 tgcagccggc aaacaggccg tagggcgtgc tgcgggtgca tgccctcacc caatatttat
    12901 acagggagcg gtgcagcttt tctgttttct tcggtgtaaa agcagcagga tccgccaggt
    12961 aacgttccag ctctttgagc agctctctgg aagcaacaga caaagcgtac aggaacacag
    13021 gaaactcctg cgccagcgcc tgcaggttat tatccagcac ccggcggtac tgttttatgg
    13081 gaaaaagcgg acttctcaat aggaagaatc ctgtatgcga taaagccata acagatcctt
    13141 taaaatttta ttgataaacg tggttcatga aagcaggaaa cattcatccc acggtaatgg
    13201 atgatcctgt aaatgcgata ataatgacaa tcctacgcca ctgccgccat ccagcaggtc
    13261 ccaggagtaa tcccatagct tatccttgcc ctgccataca cgaatgccgt gcttaccctc
    13321 ttcttctgaa aaagcgataa gctccactgc tttttgctgc caatgagcag cgcaatcata
    13381 aaaggattgc tcccctgttt caaaccagaa cttgcggtaa aaggcggcaa taccgctgga
    13441 cccatggcaa atgcagttat ctattacacc ggcagtttca ttggttaaac gccgggtatt
    13501 ataacgcatg atctccaggg cctcactcat ccagctcttt tcatccaata ctttaccaca
    13561 gtaccataag gtccatgcta cattcagatc gccgtaacac catgccaggc ggctattgac
    13621 gctggactgt ttcccatcca gtatagccgg gtacatagca tgcaggccgt taccggacac
    13681 cgggatctta tgctgcaata tgaaggggat acattccgta atgagctgcc ggcatgtttt
    13741 ttcagcaata cccgccttgt atatttttgc cagcagtatt aatgcagcac aactgccatg
    13801 cgcgaggcta aaggcatcta cataagtgcc tgcaggttgt tcgtgcgtat aaaaaatggg
    13861 aaggcttctg ccaaggggtg ttagcttgct ggcggccatc agctgatccg caaaaaatac
    13921 caggtgcgta tgcacctcct ccctggctga aaaaggcagc agaaaattac acatgcctat
    13981 actgccgtgc aggaaatcaa agttcttcca ttgcaggtgg aaccggcttt gttcaatagt
    14041 agtggaaata aattcagctg tcagcacatc aagatccatt tccaggaact catgcctgct
    14101 cagatgctcc agcagccaga acgggcctgt atggcctgaa caaaaagaat aattcagtcc
    14161 ttcatgagga gtataaccgg catagatctt ttgcagcagg gctacagcat tatccgcctc
    14221 ctggtctgca tactgctcat agtagaacat aaagagcaag gcgccccatg ggcctttaaa
    14281 taagctgccg ctaatatcgg gatcatattt ctgctggtcc agcaggggaa taagatcatt
    14341 atagatgttc cgcagctgtg tggctatcat attcattttt cagcggctgt ttaatgtctg
    14401 taaacagttt ccggattatg aaaaatggaa cagggaccac tcatccctgt tccttaaaat
    14461 tgtcggggcc tgctatcagg gtatcatgca gcagggacgg ccggggccag gactggtagc
    14521 cctgcagctg gatattaaac gggtgtcttc tgtgcaggta gctgcaaggg ttgcggcgcc
    14581 gccatttacc tgtgcctgct gatctgctgt aagctgtgca atggtttctt tgctaaacag
    14641 cagctttttg ctgaggtcta cttttttctt tttcatgatg gtaaattttt acatgagggt
    14701 cctcccctgt ctatagccat ggggtggttg ttcagcttct gtgaaaggag gtgttactat
    14761 cttacgcaat ccgccggaca ggtaacttca tcagtttcta cgcagcatgc actccaccag
    14821 gttaaggggc cgccacctgc tacttttgcc tgttgctgtt gattcagctc aacaatggtt
    14881 tcttttttca gtaataattt tttactgagc tcgatctttt tctttttcat aaaaactggg
    14941 atttatggac aaaaccttcc cctgccgcca ttgtagggca gccggttata gcctgtccgg
    15001 gttaaaaaat cagacgtgtt taatgaagac cagcaaaaaa tgcagtctag cctgccaggg
    15061 ggaatagtga aattttcctt tttctcatat gtgaggaatt acgggttatg atctgttaag
    15121 ggtttacagg tttgctatgt tacgacggtt tagataatgg gcgcaggggt aactttataa
    15181 ataccatcct tgctctatgt aagtaaacgc ataagtgacg ggttatttga gatttgcaat
    15241 ttgagattct gaagttaagt aaattgatct tgtaaaaaaa aatgttttta aaaattattt
    15301 ttgttacgtg tatgggcaga agtacttacc cgggatccgc aatatttaca aagaagcatt
    15361 atcatgaaac tcaccatcac gggatattca acggcattat tttcaacctg gtatttcgtt
    15421 gaagaattag gattgctgtt tgatgctggc gatggcatca cggctgcttt actacaaaaa
    15481 gcaagaaaaa tagataacgt ttttatttct catgcagacc gggatcattt aacaggactg
    15541 ctgcaattca accagctgaa tgccagggag ggttttccca agatcttcta tccttttaat
    15601 tccagctctt ttcctgccat agaaaccttt tcaaaaaatt ttgatccgca tgtaagcggc
    15661 actacctgga aaggcatcaa agaaaatgcg cacattcaaa taaaggacga cctgtatgtg
    15721 cagtccatca ggaataatca tgtaccggca gaaaaggatg tttttaaaag ttttggttac
    15781 caggtgtacc aggtaaagaa caaattgaaa aaagaatacg ccggcttatc acaggaagag
    15841 atcttacagc ggatcgcgga aattggcaag gagcgcatga cagaacagat caggaccaat
    15901 atactaacct attcaggaga cacgccggtg gatgatcctg aacgatggaa caacacaaaa
    15961 atactgatcc atgaagctac ctttttagga gaacaggagc tgaaccatgc aaacacccac
    16021 cggaataaac acagtaattt agagcaggtt ttaagaatgg tttcccgtct gaatattgaa
    16081 acgctgatcc tggggcattt ctcgtcccgc tattcaaatg aagaaattga caggagcata
    16141 agaactttat gcgatcagct aaaaataaaa attcctgttt accgcgtttt gcctggcgag
    16201 gtaaacagga atatactggc cggggagcca attaataata cgatctaaaa cacgcctcct
    16261 ccggctccta tattctgccc ggtgatccac ctgcccgcat cgctggccag gaaaacagtt
    16321 acatcggcta catcttccgg ctctcctacc cgtttaaaag gagacatggc cgcagccacc
    16381 gcccggtcgc gctccggtaa cagatccgta ttcgtaaaac ccggagatac tgcattgact
    16441 gtaatgttgc gctctcctaa ttcccgggac agcactctta caaattgctc tatcgctcct
    16501 ttactaccca ggtaaatggc gttcatggaa aaatacattt gtgtgccgcc ggtagaggtt
    16561 acgatgatgc ggccgccatc ctttaccctt ctggcggctt cctgcaacac gaaaaatata
    16621 ccttttgcat tggtgttgaa cacagcgtca tattgctctt ccgtggcttc ggataataaa
    16681 gcggggatat agctggcggc attggcaatt acgatatcag gtttccctaa tgatgcttcc
    16741 gctttttcaa aaagtgtttt gatagccggc agctgagaga tatctgcctg tatggcaatg
    16801 gctttaccat cctgctgcct gatcttttct gcgatctgtt ccgcagcagc ggcgctgttc
    16861 acataattaa tggccacggc ggctccggcc gcggctaaac gttctacgat ggcctttcca
    16921 atacctcttg aaccacctac tacaatagcg gttttaccct tgagggcatc atttgcaaat
    16981 gttgtcataa cgggcgcttt tattgaggga ataaagttaa aacataacta cacagcttgc
    17041 acccggcctg acaccacaat tttttttata tccagcttac cgcttactgc attaaaccgc
    17101 acctttccat tcttctggct tacatttccg aaaccgcttt ccgtgctcag gaagctggta
    17161 aagtcgccca cctttgaatc tacgtacaat gttctttcaa ctgcatcata acgtacgccg
    17221 gttaaagcct gcagcaatcc atagctggac attgcccttg cataccaatg cccgcattca
    17281 tattcattga acgggttacg cactttacca ttataccggt cccggcatgt tcttacaata
    17341 tccaggcctt tttccacctc acccataaag atcaggtgcg atgctacctg gtattcgata
    17401 cccgtccaca cctcattgct gtacacaaaa ggcagcgaaa gctttcctcc tttaggccag
    17461 gagcacaaca gcaggccgcc ctcttttccc agcgcatacg taggtctttg cgggttagca
    17521 tgtgaggaaa gatcctgccg caggttatat ttatacactg cagccaggtg gcttttaatt
    17581 ttaccggcat ctataatatc atccagcccg caaacccgtg ctatccaggc tcccagcaca
    17641 ccatcagata aacagccggc gccgtactga tatttagggc cttctttttt taacagctcc
    17701 agagcttccg gtgaataacc ggtgctgaat gattgcgcct ttaccggatc aggtgcattc
    17761 aaccctgtcc actggatctt ctgaataaaa aactcaccgt tataaagctc cgtttccagc
    17821 tgctgtttgc ctttattata cagatcctta taggcagctg catcctggtg cagatgttcc
    17881 gacatttcag tgaatgcgcg taatgcaccc aggtaaaagc tggtgcacat accggtagcg
    17941 ccccagaact ctatatcata ggtgttatga tgcggctctt ctatcacgcc ttttttgcgt
    18001 gggtcccagg ttttgataca atagtccagg ctttttttca cagcaggata catggtttgc
    18061 agccactggt catcgcccat gatcctccat tcgcggtaca ctttcataat gcctcccagc
    18121 tgcccgtctg cagcggaatg aaaggtgtgc ttcacctttg tgatgggcat gtttgcgcgg
    18181 aacacctggt gccctgcttc attctggtct tcattaaact ctgtttcccg caggcttctt
    18241 tccaataccg ggaacaagtg cggtacagcc tgcgcatagt tccatacatg cgtgcaggag
    18301 ccatggcagc ttccccagct gtcgccggag ccttcccagg cccagaaccg gccttcataa
    18361 ggccgcatta ccgtagtaga ttttaaaatg gtaaggttag ccgctattgc ttctaaaacc
    18421 tccggcggca atgttgaatt ataaaatgct ttctgaaaca gtaacgactt ttgctgcagt
    18481 gtttcgtaat tggttttcca gtagtccgca atgttttgta tactattaaa gcgattgctg
    18541 taccaggggc ggtaaaacct tgcttcggaa tgatctgctt catcctcctt ttcaaactcg
    18601 cctatcctta acgtggaatg cggcacatac caggccatca ttaagcggat ggttttctgc
    18661 tgaccggggg ccagtgtaaa aggcacatac agcgatgcgc cgggtgcatc tgcattcacg
    18721 ggcggcgtgt tcctcagctg cccatcgctt acggtgttcc ataccataga aagcggatca
    18781 aaccaggcgc ccctgaacca gcaatgatct accacggttg cgccctcatt ggtgaagatg
    18841 gcaaaatggc cttcttttga aggcgcctgc tgcgtacctg cagaagatag tataaaacca
    18901 ttgctgatag cgcctatact attggcagca tcctgctgct gcataaaatt gcgggagtgg
    18961 taagagaaga tcagctcctg tgtgctgctg ccggtatttt tgaaagtata ttccagcccg
    19021 cctaccggca aacctgaatg gttttcgtca ttgggtataa aaggattcca ggcctgcagg
    19081 cttacggaaa gcggcatgct ttcatctttc atgcttactt ttccaaaagg aaatcttgct
    19141 tcaaattcag cggctgcaaa tcttggcaat ccccaggtag ccccgcccct gccgcctaag
    19201 ccggaatcac gctgcccgaa ttttttccag tccggcacct tcccttccag cacccggggc
    19261 gcatggcctt ttatttttat tgctgcaaac atggccggct catgataaat ttccggcaca
    19321 tgccttaccg acatatgaga gatagcgcct gtaccttcca cgcaaaacat gccggtacct
    19381 ataccaccta ccggaaaagc gatcatatta ttgaattctc cggtgtaggc gctgttgtac
    19441 ctgcgctgcg gtgaagggtt ttcctttatt gttctttccc gttctgttct atggctttca
    19501 gcatgcaggg ttaagggtgc aagcccggcg ccaaggccgc ccagcgcaat attcttcagg
    19561 aagtcgcggc gcctgttggg tcttttcata acgcaaagtt ttagttcctg aactaaactt
    19621 atgcaataat gatgtgaact gcaattgtgt aaacaggtaa agccaacatc ttatcagaat
    19681 ttgtattttt tttacaggtt ccgggaaaat tactgtttaa tagcggcgta cgatggctac
    19741 ctgcttggcg gggcagccat cgtattacct gcagctattt aatcgggcaa tgcaaaacct
    19801 gtttgcaccc attcaaaacc atcttctttt ttccttacat gacccagacc cggccagggt
    19861 aaatgataag aaaaaacctg ctttctattg gccgccagct cacctaatac ttttctgcgt
    19921 gtagcagccg ctaattcaaa gtttgtatcc ccttcaaatc cccactcagg gtgcgcaaat
    19981 accagcacag gcgagtgtac caggtctgcc acatgcacca gctcctgccc ttctgaaaaa
    20041 atggtggtta cggtatggcc gggtgtatgg cctggcgcca ggttcagtct tatgcagtca
    20101 aacagggtat cgccatcttc aaacaaatgt aatctgggtt tggttttagt aagggtttcc
    20161 tgcgcaacgc gtatcactaa agctttcagc tcctggtcat ccattttgct tttggagaaa
    20221 tccggctgtg ccaccatcca gaaatcgtat tctttttgag ctatataaat atccgcattc
    20281 ttaaacggca tgttgccatc tttatccagt aagccgccca ggtggtcggg gtgagcgtgg
    20341 cttaacacca catctgtaat atcctgcgga tgaatgccgg ccagtggtaa gtttttaagc
    20401 agccatcctg aattttctcc cagggagctt ccacagccgg tatcaaccag gatctgtttg
    20461 ctgccggtat taatgatcag cacattaata cccaggtcaa cggaatcagg caaaaagttt
    20521 tcattcaata atttctcaac cgctgctgcg ggaaaaccag gcgcaaaacc aggctgcacc
    20581 tttttaaaca ggatatgtcc atcggttacc acttttaatt taagctttcc cagctcaaat
    20641 tcatgaaagc ccgtataggc gttgggttta cgccttttta tcatagccgc cagcggcgcc
    20701 aggggcaatg ctgcggacaa ccccagcaac aacccgttct ttatcaaagc tcttctttcc
    20761 atattttttt acctgcaaat gtagatgcgt aatacctttg tagcaagtat gcactttttg
    20821 ggaacctacg caccatttgt atactaatgc tgataatgag tgaaataaaa gtctatgact
    20881 aagacaaatc tgaaagataa acaggcctcc tgcgcagtgg actatggttt ccagcgtata
    20941 ggcggtaagt ataaatgccg cctgatctgg tatattcatg aacgcaaagt tgtgcgttac
    21001 ggtgagttaa agcgaatggt taaaggcatt actcctaaaa tgcttacgca aaccttgcgt
    21061 gagctggaag aagacgggct ggtgatacgg aaagcttatc atgaagtacc tcccaaagtg
    21121 gaatacacct taacgcccat tgccgaagag ctgatcccct ttatcaatca tgttaaacaa
    21181 tgggcggaaa ggcgtatgga agaattaccg gaccctattg agcaaatagc ctgttagtta
    21241 acggctgccg ttatatccca aagcttaccg ctttgcgtgc ctgttaaaat accctggtaa
    21301 atgccctcgg ccgattgctc cggggttaag ggggcctggt cgccgcctaa tttggtttgt
    21361 acccagcccg ggtgaaccgg cattacacgg atgctgctat cagccaggcg ggtggccagc
    21421 atggctgcat acatattaat agctgctttt gataagcggt aaccggggcc attgggcgct
    21481 gcattttccg gcaggcccat attgctggaa ataaaaatta tctgtccgcc ttcgttgata
    21541 tgctccagta aaggctctgt aaaaaacaca gcgccggtaa tattggtgtt gagtgtttgt
    21601 gtaaaggatt ggtactccgg ctccacggca aatacatccg gcgcagcgcc ggcattgttg
    21661 atcagcagat caataccgcc tgttaatgta aggatgcgct caacggcctg ctggctgctt
    21721 tgccggtctg tggcttccaa agcaatgatc tgcagatccg gatgcgaaag ctcttttaat
    21781 acgccagatc tcgtagtgcc gataacgtta taaccttcgt tcaatagttt tttagtgagc
    21841 gctaaaccta ttccgctgct gatacccgta actaccgctg ttttatttaa cctgttcatg
    21901 atgctgttgt ttaacttttt ttaattacca cctaaacctt ttgctgccca aacaccgctt
    21961 tgcagcagca gcccgaacca atcttccagg tgccaggtat gcgtaagcct gccatccttc
    22021 aggtggtgga actcatgcag ggccagggct acttttttcc cggtagccgg aatacccatt
    22081 aactcgttat tgtgcgtaaa tacaaaggag gcacgcacac cggcgcgctc ataggtgccg
    22141 taaatttcat ggatcacaat ttccacatcc gggaaggtag ctgaaaaccc gcggataata
    22201 tcctgtaatc ctttaggccc ctctgcctgc cccggtccca ggggaatgtc ctgccagtca
    22261 ggggtgcata cttcatccag cagctccggc tgctttttct tccaggcgct gtaaaaaact
    22321 gttatagcgt tacgctctgc tgccgttaat gctttaacca tttctggctg ttcatgttgt
    22381 actgtcataa ttcatttgtt tatgcgtaca aaggtcgttg catgataagg tatagctatg
    22441 gtgaggtttt cagtttataa aaaaatcccc tgaaatcttc ctttacattc agaaagactt
    22501 caggggaatt ataattcctg gtgtatgact gtatttagtt ctctttcatt tttgcctgga
    22561 tctcttccag ggttaaattt tctcctacca caatcccttt ttcatccagt aagaacatag
    22621 cagggatagc acggatcttc caggcattgg cagttttacc tttatccagg aagctgggcc
    22681 agggcagctt ttcttctttc tgcgccttca gccagtctgc ctcttttttg tcgatagata
    22741 cactcacgat ctgcacgcct tttgcctgca agtccgcata ggaacttttc atagcgggga
    22801 tagctcggcg gcagggtcca caccaggaag cccaaaaatc aaccagcaca tatttatggc
    22861 ctttggtcag cgaggcaata tccgtaggta tgctggtgct tgcctttaga tccagcaggg
    22921 gagccggttg cccggcaaag cctttcgggt tcagctgctc gtacagcagc ttaccataat
    22981 aactatcttt tgcttcctgt gagaactgtt cgtacaccgg cttatccttt ggcgtaaaat
    23041 agttgtacag atccagcgcc aggaaaggcc cccaccaggt atctttatta tcgcggataa
    23101 ttttttcaaa cgtagctgta accagcttaa agaaagcaga ttcccttgca tccatttgtt
    23161 tataggcttc tgtttccttc aaagacttca acaatacggt gtctttgttt ttataagctg
    23221 cgttcacctt ttctgaaatt tctttactgg cttccctgtt ggccatgtaa acggaatcca
    23281 gcatttcccg gggcgctttt ttctgaagga attgcgtatg cgcatcactt ccctttacta
    23341 acatgtgctc aaattcatag aatttattgt cgccgttccc tgaaagccgg gcatcacccg
    23401 tgagggagat ctccccgctt tgcaccatca atgaataata gccccggggc tctgctaaac
    23461 gtatataaaa aaggcggggc tcaggtacct ctccttttaa ttcaaattta ccctggctca
    23521 cggttgctgt tgccaccggt gcttcgtcct gatgggtggc gccgggaacc agctctactt
    23581 tggcgccatc cggcagtcct tttataagac cggtaatggt aaagggtttt gactgggcat
    23641 atccgctgta tgtaaatact aacagcaata atattaacgg ggtgcttctt aggttgaact
    23701 tcatatgctt taaggtttta cttgtttacg ttttgtgtga tagttccatt ccccgggttc
    23761 ttaatagcgc cctggggaaa tggcatggtc cataaatgag aggccggaga aaggcttagg
    23821 cttacaccat tttctgtctt ggtgagtgtg cgggcataat ccggatcttt attcaggcgg
    23881 cgcatgtctg caaaaggcgt aatacccagg atcagctcat tgcccttggt gcgctggatc
    23941 agctttacgg catcctgcac cgtggtggcg ctaagcgctg tataatactg cggcaggatc
    24001 cgttttaccc gaacggcatt taaggtgttc atagcgcctg aaatatcgtt ctggcgggcc
    24061 tggcattctg ctttgatcag gtatacttct gtggtggtaa acccgccgta attataaaag
    24121 cctgtggtta tgcttttgaa atacgtatct gcacccacgg tccttaactt ccagcgggag
    24181 gcaaatcttg catcgccctg ctcaaaacgt gtggcgcggt cggtacggat gttgacctca
    24241 gtgctggagt actgcctgcc gccatggcgg aagctgtagt tctccacaaa atcatatccc
    24301 attggagagg gtgcattaac atattgatcc ggcgcttcga tctgtgtttt gtatttgtta
    24361 tagaactccg tccagt
//
