LOCUS       NZ_FOBB01000005        20972 bp    DNA     linear   CON 22-OCT-2024
DEFINITION  Chitinophaga rupis strain DSM 21039, whole genome shotgun sequence.
ACCESSION   NZ_FOBB01000005
VERSION     NZ_FOBB01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Chitinophaga rupis
  ORGANISM  Chitinophaga rupis
            Bacteria; Bacteroidota; Chitinophagia; Chitinophagales;
            Chitinophagaceae; Chitinophaga.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900109685.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 15:41:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,474
            CDSs (total)                      :: 6,410
            Genes (coding)                    :: 6,392
            CDSs (with protein)               :: 6,392
            Genes (RNA)                       :: 64
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1, 1 (16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 18
            CDSs (without protein)            :: 18
            Pseudo Genes (ambiguous residues) :: 0 of 18
            Pseudo Genes (frameshifted)       :: 4 of 18
            Pseudo Genes (incomplete)         :: 13 of 18
            Pseudo Genes (internal stop)      :: 2 of 18
            Pseudo Genes (multiple problems)  :: 1 of 18
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:12:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 439775
            Orig. end                         :: 460747
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOBB01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20972
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20972
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20972
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10972](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10972
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    201..217
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 21.94"
                     /tool="antismash"
     misc_feature    365..381
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.6"
                     /tool="antismash"
     gene            complement(648..1715)
                     /gene="fbaA"
                     /locus_tag="BMZ54_RS21170"
                     /old_locus_tag="SAMN04488505_105341"
     CDS             complement(648..1715)
                     /EC_number="4.1.2.13"
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fbaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018628099.1"
                     /locus_tag="BMZ54_RS21170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105341"
                     /product="class II fructose-bisphosphate aldolase"
                     /protein_id="WP_089916967.1"
                     /transl_table=11
                     /translation="MGKYRAGVLFGEELEALYKDAKDNAFAMPAVNVVGTNSVNAVLET
                     AAKVNSPVIIQFSNGGAQFFAGKGMPNDKLQANIAGGVSGAKHVHEVAKYYGVPVVLHT
                     DHAAKKWLPWIDGLLDAGEAFMKQTGQPLYSSHMLDLSEEPIHENIEISKKYFERMNKL
                     GMSIEIELGVTGGEEDGVDNSGVDNAKLYTQPEDVAFAYETLLQVGPRFTVAAAFGNVH
                     GVYTPGNVELRPEILKNSQDFIQEKYKTPAKPVYYVFHGGSGSPKHQIAEALGYGVIKM
                     NIDTDMQWAFWEGIHDYYEAKKGYLQAQLGNPEGADKPNKKYYDPRVWLRKGEETFVKR
                     LEEAFADLNCINKNA"
     misc_feature    1722..1740
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.63"
                     /tool="antismash"
     misc_feature    2089..2105
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            complement(2392..2826)
                     /locus_tag="BMZ54_RS21180"
                     /old_locus_tag="SAMN04488505_105342"
     CDS             complement(2392..2826)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012575.5"
                     /locus_tag="BMZ54_RS21180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105342"
                     /product="ubiquinol-cytochrome c reductase iron-sulfur
                     subunit"
                     /protein_id="WP_089916975.1"
                     /transl_table=11
                     /translation="MERRDFVSHLSMAMALACAGGLAACTKHMADAPDNNNGGGNAKLT
                     ADLSTELLNTGNFKIGGGVILIRIAAGNTPSAFSALSSTCTHQGCTVSTFNTGSDLIEC
                     NAPCGHGSRYTTTGAVQTGPATAALPKMTVSINGNTLSVS"
     misc_feature    complement(2875..2893)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.5"
                     /tool="antismash"
     gene            complement(2905..3747)
                     /locus_tag="BMZ54_RS21185"
                     /old_locus_tag="SAMN04488505_105343"
     CDS             complement(2905..3747)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014220694.1"
                     /locus_tag="BMZ54_RS21185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105343"
                     /product="helical backbone metal receptor"
                     /protein_id="WP_089916978.1"
                     /transl_table=11
                     /translation="MGYRIHIDQLHNEVSIPARPRRIISVVPSQTELLYHLGLEEEVVG
                     ITKFCVHPEEWFRNKTRIGGTKTLDLDKIRALQPDLIIANKEENQQEQITALQMEFPVW
                     VSDIHTLDEALQMIRRVGEITGYAKQGLALSMQIQEQFKGLHEALPVTELHAAYFIWRN
                     PWMVAGGDTFIHHMLAACGLTNVLADMPRYPAVTLEELTTLFKDVPPAQQLILLSSEPY
                     PFKEQHIAEIQAVLPGAQIRLVDGEMFSWYGSRLLEAPEYLRELLHSSSYPGSTGNLL"
     gene            complement(4002..5360)
                     /locus_tag="BMZ54_RS21190"
                     /old_locus_tag="SAMN04488505_105344"
     CDS             complement(4002..5360)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014220693.1"
                     /locus_tag="BMZ54_RS21190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105344"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_089916982.1"
                     /sec_met_domain="PALP (E-value: 6.2e-69, bitscore: 227.1,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFCNNILETIGHTPLVKLNRVTAALPCPVMAKVEFFNPGNSIKD
                     RMAVKMVEVAEQQGLLKPGGTIIEGTSGNTGMGLALAAVIKGYKCIFTTTDKQSKEKMD
                     ILKAVGAEVIVCPTNVEPEDPRSYYSVARRLSKEIPNSFYVNQYDNLANRDAHYEQTGP
                     EIWEQTDGKVTHLVVATGTGGTVTGAGQYLKEKNPAIKVWAIDSYGSLLKKYHETGEID
                     MSEVYPYITEGIGEDFVPQNYDMRYIDHFEKVTDKDGAIMARRIAKEEGIFVGYSAGSA
                     IAGLLQLKAQLKPTDLVVVVFHDHGSRYVGKIYNDQWMMERGFLDVKTVKDVVNGRRNL
                     PLVTIGGEEKVSDAIAKMKKFEIEHIPVLHNGDIIGAISEGGLFNKLMDDVNLKDAPVK
                     QVMHAAFPEVSMDTPIEKLAVYINKENGAVLTKDDSGSWHIVTKYDIIQALGS"
     gene            5461..6084
                     /gene="bioD"
                     /locus_tag="BMZ54_RS21195"
                     /old_locus_tag="SAMN04488505_105345"
     CDS             5461..6084
                     /EC_number="6.3.3.3"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004141 - dethiobiotin synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0009102 - biotin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bioD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791303.1"
                     /locus_tag="BMZ54_RS21195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105345"
                     /product="dethiobiotin synthase"
                     /protein_id="WP_089916988.1"
                     /transl_table=11
                     /translation="MSNRIFITGIGTGVGKTITAACVTQALGADYWKPVQTGLLEGTDT
                     QTVRALLSNTTSVCHKEVYCLQEPASPHLAARLENVTIDPALILQQASIIQPPQRSLVI
                     EGAGGLMVPLNEDVFTLDLIRQLQAKVIIVAQNYLGSINHSLLTARVLQASDIPVLGWI
                     FNGDHHSNEEDVVRWSGYPKLGRIPHATVVDANFIALQAKQLMF"
     gene            6109..6693
                     /locus_tag="BMZ54_RS21200"
                     /old_locus_tag="SAMN04488505_105346"
     CDS             6109..6693
                     /EC_number="6.3.3.2"
                     /GO_function="GO:0030272 - 5-formyltetrahydrofolate
                     cyclo-ligase activity [Evidence IEA]"
                     /GO_process="GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02727.1"
                     /locus_tag="BMZ54_RS21200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105346"
                     /product="5-formyltetrahydrofolate cyclo-ligase"
                     /protein_id="WP_089916991.1"
                     /transl_table=11
                     /translation="MFTKTDIRKQFLERRLNMPAEDAAALNQHLLENCQKVNYSRIRWA
                     HIFLPITEKKEVNTWPIVTWMRQAYPALQWVLGKASLATADMEHFLWEEHTPLVKSRYG
                     IPEPAGGIPVEPGTLDLVFVPLLAFDLTGHRVGYGKGMYDRFLKQCRPDVRTIGLSLFE
                     PVDVIMDADIHDVPLQTVITPVTIYQFIEKQ"
     gene            6690..7769
                     /gene="lpxK"
                     /locus_tag="BMZ54_RS21205"
                     /old_locus_tag="SAMN04488505_105347"
     CDS             6690..7769
                     /EC_number="2.7.1.130"
                     /GO_function="GO:0009029 - tetraacyldisaccharide 4'-kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009245 - lipid A biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lpxK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791305.1"
                     /locus_tag="BMZ54_RS21205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105347"
                     /product="tetraacyldisaccharide 4'-kinase"
                     /protein_id="WP_089916993.1"
                     /transl_table=11
                     /translation="MKVLRYLKFLLYPFSLLYGLVMWIRNRLYDAGTLTAVSFDLPIIA
                     VGNLSVGGTGKTPHVEYLIRLLKEHFTIATLSRGYNRRSRGYQLASENSTAAQLGDEPM
                     QFHQKFPDISVCVGEERMLAIPQLLGEKPETQVILLDDAFQHRSIKPGFNILVTEYNRP
                     FTRDHVVPFGRLREGRKGYERASCIIVSKCPPNMGETEKQALQREINPLPYQRLFFTSL
                     QYGQPYDLFTQAPMLISPDATLLLVCGIARPAPLVQHLKEGFKEVFLLPFPDHYYYSNN
                     DLEKISKELKDLPGAEKVVITTEKDAVRLHLLQERLQELNLRIAVIPVEISLLFGEGNS
                     FNNYIFDYIVGTGTSYIRT"
     gene            7781..9955
                     /gene="rnr"
                     /locus_tag="BMZ54_RS21210"
                     /old_locus_tag="SAMN04488505_105348"
     CDS             7781..9955
                     /EC_number="3.1.13.1"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rnr"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014217212.1"
                     /locus_tag="BMZ54_RS21210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105348"
                     /product="ribonuclease R"
                     /protein_id="WP_238386640.1"
                     /transl_table=11
                     /translation="MNKKKKQKKGNHSGPKKTFRGMIEVTRSGMAFVIVEGLTKDILVK
                     QKNLNTALDGDEVLLDVLKDHSNKNNGRMEGVVTDILKRKKTEFTGTLQVNKGFAFLVP
                     EKGAFLPDIYIPANSLGEAKTGDKAVVRVVAWGEKTRKPVGEIIEILDASDTNDLAMKE
                     ILVESGFPLSFPDEVIAELAEIKEKITAAEVRKRKDFRKQLTFTIDPVDAKDFDDAISI
                     RKIKGGYYEIGVHIADVSHYVLPDTALDKEADKRATSVYLPDRVLPMLPEKISNELCSL
                     RPNEDKLTFSAVFQMNEKGEIKQHWLGRTVIHSDHRFTYEEVQEIIEGNSEGPHKEEVM
                     LLNKIARILRKGRFDEGAINFSSQEVRFQLDPDGKPIGIVIKESKEAHQLIEEFMLLAN
                     RTVAEYVSKIKVNKQSVPFPYRVHDTPDEEKLQVFSIFARKFGHKFDLDNPDHIARSFN
                     KMLQLAKGKPEQHVLETIGIRTMAKAIYTPDNIGHYGLGFAHYCHFTSPIRRYPDVLVH
                     RVLAQCLAEDIHPDKYMEKKCRHCSEMERKAMEAERAANKYKQVEYMQQFIGDTFDGVI
                     SGVAHFGFWVETIDTKCEGLVSIHNMMARDEFKHDESEYALVGLHTGRRFRIGDKVKIR
                     VMSANLTKRQLDYDLVEDLEEQQPASRPGNIGKPKRKEKEKERGERVQQGPGKKPKPNK
                     PGSKPKPKAADNNNASKPAKAKPRPRKKEL"
     gene            10001..10972
                     /locus_tag="BMZ54_RS21215"
                     /old_locus_tag="SAMN04488505_105349"
     CDS             10001..10972
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791307.1"
                     /locus_tag="BMZ54_RS21215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105349"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_089916996.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.1e-65, bitscore:
                     216.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSFQELIAQFIQQFDQQRFPDQPSTLYNAASHILKIGGKRIRPV
                     LALMGNELFDTIHADAWQVGNAVELFHNFTLIHDDIMDKAPLRRNNPTVHTLYGEPAAI
                     LAGDAMLIYVYEYLNRVQSRYKQKIVSVFNRAAIQVCEGQQLDMDMEAMDPAQVKYDDY
                     VSMIALKTSVLLAASLQMGAIIGGGSEGNQGYLYEFGKNIGIAFQIQDDYLDAFGDPEK
                     FGKQQGGDILANKKTFLLLKALELCNPAQRIRLQQLLDTAPDDKVAQVLELFHDCSIDS
                     WAEKEKERFQQKAFDNLESIAVLSSRKKPLMELADFLLSRQH"
     gene            11102..12733
                     /locus_tag="BMZ54_RS21220"
                     /old_locus_tag="SAMN04488505_105350"
     CDS             11102..12733
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014217214.1"
                     /locus_tag="BMZ54_RS21220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105350"
                     /product="amino acid permease"
                     /protein_id="WP_089916999.1"
                     /transl_table=11
                     /translation="MSKSLFRRKSLSTILKDAREGLTDAHGTGSLHRVLKVKDLTAMGI
                     AAVIGAGIFSTIGEASFHGGPGVSVLFIITAITCGFSALCYAEFASRVPVSGSAYTYSY
                     VTFGELAAWVIGWSLILEYAIGNIAVAISWSGYFNNLLSGIGLPLPGWLISNYDNATPE
                     TLAAAPHIGSIPVIVNLPAFLVVVFITWLAYVGIQESKRSANFMVAFKILVILFVIVLG
                     AFYVNTDNWHPFMPNGFSGVLKGVSAVFFAYIGFDAVSTTAEECTNPQRDLPRGMFYSL
                     IICTILYILISLVLTGMVPFTELKVSDPLAFVFDRVNLKWVSYIISVSAVIATTTVLLV
                     FQIGQPRIWMSMSRDGLLPKRFSKIHPRFKTPSFATIITGILVGVPALFLNLTIVTDLT
                     SIGTLFAFILVCGGVLLLPREESNTQRFQLPYINGRWIVPGLIVLFIILFHTQIQEKWS
                     FAGGWDVWKHNIPFYLFTIVAILITVFSFLRKLSLIPVLGLLSCFYLMTEMGLKNWIVF
                     AIWLLTGLVIYFSYSYRNSKLSTAEA"
     gene            13058..13495
                     /locus_tag="BMZ54_RS21225"
                     /old_locus_tag="SAMN04488505_105351"
     CDS             13058..13495
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791310.1"
                     /locus_tag="BMZ54_RS21225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105351"
                     /product="DoxX family protein"
                     /protein_id="WP_089917003.1"
                     /transl_table=11
                     /translation="MNLLQKIEIWGDRHHPKWLDAVRIGLGIFLFWMGVLFVQNRDALT
                     ALINENPTLTVVSFWLAHYIVFAHLAGGVLIMLGSLTRLAVLVNIPVLIGAVFFVHSPT
                     GLFAVHSIPGISIVVLLLLVFFLIEGSGPLSVDEYMRRHPA"
     gene            13671..14696
                     /locus_tag="BMZ54_RS21230"
                     /old_locus_tag="SAMN04488505_105352"
     CDS             13671..14696
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013844.5"
                     /locus_tag="BMZ54_RS21230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105352"
                     /product="Smr/MutS family protein"
                     /protein_id="WP_089917006.1"
                     /transl_table=11
                     /translation="MKYEIGDKIILLHSKEEGTVVDIVNREMVMVEVGKTTFPVYLDQI
                     DFPYFYRFTEKKLPAAAPRKVPGDELPVEKKKHETFKTDKGMFLSILPVYQADGYEENI
                     QLLKFHLLNETQRSYTLHFRVWLKQQLDLEIKNDLQPFSHFYLSDLLFESLNDSPRFEF
                     TFYPREKDPKLAPSFNKVWKIKPKQLFQQLNELHIRRDAMLSFPLFEKYPDKQPDTRYG
                     FEAEDISKLSPLYSKIQLAPDAPLEPKYEVDLHIEKLIDEWRGLSNIAILAIQLNEFQR
                     YLDLAIAHKQPSMIVIHGLGKGKLRDEIHQLLRQTPEVGNFVNEYHPRYGYGATEISFK
                     Y"
     ncRNA           14720..15092
                     /db_xref="RFAM:RF00010"
                     /gene="rnpB"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00010"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="BMZ54_RS21235"
                     /ncRNA_class="RNase_P_RNA"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /old_locus_tag="SAMN04488505_105353"
                     /product="RNase P RNA component class A"
     gene            14720..15092
                     /gene="rnpB"
                     /locus_tag="BMZ54_RS21235"
                     /old_locus_tag="SAMN04488505_105353"
     gene            15147..15560
                     /locus_tag="BMZ54_RS21240"
                     /old_locus_tag="SAMN04488505_105354"
     CDS             15147..15560
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021221.5"
                     /locus_tag="BMZ54_RS21240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105354"
                     /product="DUF4870 domain-containing protein"
                     /protein_id="WP_089917011.1"
                     /transl_table=11
                     /translation="MDQNQERTWGALVHLGGLIGMFILSFVGNIIGALVMWLIKRNESA
                     FIDDQGKEALNFQITLSLVNVAIGLLISLRHGIWAFRSIWRDHDFDGWHGFGSAISLYG
                     IVSLLNIIFSIIAAVRANKGIRYRYPLCLRIVK"
     gene            complement(15729..17399)
                     /locus_tag="BMZ54_RS21245"
                     /old_locus_tag="SAMN04488505_105355"
     CDS             complement(15729..17399)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018629288.1"
                     /locus_tag="BMZ54_RS21245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105355"
                     /product="S8 family peptidase"
                     /protein_id="WP_089917013.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.5e-52, bitscore:
                     172.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRRAVAVLAGSVVLMTASISTFAQGTSIPRNWHLLSYDKDSVL
                     GIGAEKAYKELLKGKKSTPVVVAVIDSGIDTTHEDLKSILWTNPKEIPGNNIDDDGNGY
                     VDDIHGWNFLGGKDGRSVKEASDEATREYLRYRRIYGNPDSTMDRSSREYAYWQKLVEK
                     VVKPTSQYKASYRTMTKLHDNMLKCANILTTYLKQDDFNGPRLDSIETTDQDVMVAKNF
                     MTRLLQSTGEQNVAYLDFKSEFEEYIDDLKKKAERADEGEVDKRKEIVGDNTDDINDKY
                     YGNNDVMGEFAFHGTHVSGIIAAARNNNVGIDGVADNVRIMAVKVVPDGDERDKDVALG
                     IRYAVDNGAKVINMSFGKGFSPNKDWVDDAIKYAESKGVLLIHAAGNDASDNDVVDNFP
                     SAHYNDHSRATNVITVGASGAGRRTSKVANFSNYGKTEVDLFAPGVQIYSTVPGGNKYG
                     SASGTSMAAPVVTGVAALVLSYYPSLTAQQLKMVLEKSVSPLTDSMVTKPGTEEKVPFS
                     SLSVTGGIVNAYNALQLADSMVNGDKKKGKPKLQPVKKG"
     misc_feature    complement(17821..17835)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.78"
                     /tool="antismash"
     gene            complement(18332..19861)
                     /locus_tag="BMZ54_RS21250"
                     /old_locus_tag="SAMN04488505_105356"
     CDS             complement(18332..19861)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791316.1"
                     /locus_tag="BMZ54_RS21250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105356"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_089917016.1"
                     /sec_met_domain="Aldedh (E-value: 1.1e-139, bitscore:
                     460.4, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIADILKEFNIPARHSGVSTGKHWLKGEGEVLSSFSPVDGKEIAQ
                     VQSGSKAEFDAVVAAAEEAFKEWRQWPAPKRGEVVRQIGEALRTHKTSLGKLVSYEMGK
                     SLQEGYGEVQEMIDICDFAVGLSRQLYGLAMHSERPGHRMYEQWHPLGVVGIISAFNFP
                     VAVWSWNAMLAWVCGDVCIWKPSEKTPVTALVCQHIVQSVFAANQVPEGVCNLVTGGRE
                     VGEWLTHDTRIPLVSATGSTRMGKAVGSAVGARLGRALLELGGNNAIIISEAADLDMSL
                     IGCVFGAVGTAGQRCTSTRRLIIHESVYDAFTQKLVNAYKQLRIGDPLNENNHVGPLID
                     KQAVQAYQQALEQVTKQGGRFLVEGRVLEGKGFESGCYVQPCIAEVQNYFDIVQHETFA
                     PILYVIKYKTLAEAIDIQNGVPQGLSSAIMTLNLREAEQFLSSAGSDCGIANVNIGTSG
                     AEIGGAFGGEKETGGGRESGSDAWKNYMRRQTNTINYSNSLPLAQGISFDL"
     gene            complement(20009..20893)
                     /locus_tag="BMZ54_RS21255"
                     /old_locus_tag="SAMN04488505_105357"
     CDS             complement(20009..20893)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012791317.1"
                     /locus_tag="BMZ54_RS21255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105357"
                     /product="DUF1338 domain-containing protein"
                     /protein_id="WP_089917021.1"
                     /transl_table=11
                     /translation="MLEQVLSGLMQRYMERVPDVKAIIQAMIQEGIIAKPEDVENDHIA
                     FRTMGVPQLGIQSLEKIFLHYGYTKKSAYHFPEKKLDAFWYAPPAPHFPRIFISELRVQ
                     DLSPKAQELIRSYTNEVKSDPVDALNLDDASAVDSFLHSGLWRLPTLEDYKLLAAESEY
                     AAWVIYNRYYLNHFTISVHNLPPGYNTIPEFNAFLERKGFTLNNAGGKMKVSPDGGLLQ
                     SATVANMITATFANNETHPIAGSYVEFAERKVLPQFAHLPTDQVKREHRRDGFEAGNAD
                     KIFESTYSSQTGR"
ORIGIN
        1 gcgcttttgc gcatccttta aacgctcgcc gtaaggtttc aggtcctgga agcccagcat
       61 atccttggga tagatgttgg gaaacagctc ttcgtattga ttattgtcaa aaagaatttc
      121 gaaatattct gccgagttga tacggttgtg gtaattacac ttatcgcaaa cgtagtaatg
      181 ttcccgcagg tcctttacag tggtggtttt cttacaatta ggacatttat gccataatcc
      241 gtccggcgct tccttctttt cactggtagt ggtattgatg ccctgtttaa tgcgtttaaa
      301 ccagcttgac atatttttct gttaggttaa aaaatagtgg tgcaagatac gaattaaaat
      361 cacatgcact ttttccgttc gcaatattac aggaaaagaa actggttccc aatagtttac
      421 cccataaaat tatatatttt ctttatttaa tagaataagg ggcgctgcac cggggttaaa
      481 agggtatctg agagacggga aacggcccgg acaggccgct acggctcagt ggcaaggtcc
      541 tgcacgacca ggaaggagag acgttccccc gccgctgtaa ttaaaaaagg gtgaaaggcc
      601 tgaaaccctt caccctgcgg taaatttgat ccctgaatgg gcgtgaatta agcgttcttg
      661 ttgatgcagt tcagatcagc aaatgcttct tccaggcgtt ttacaaaggt ttcttcacct
      721 ttgcgcagcc atacgcgggg atcgtagtat tttttgttcg gcttatctgc gccttccggg
      781 ttgcccagct gagcctgcag gtagcctttt ttagcttcgt agtagtcgtg gatgccttcc
      841 cagaatgccc attgcatatc ggtatcaatg ttcattttga tcacgccgta acccagggct
      901 tcggcgatct ggtgtttggg agagccggaa ccgccatgga aaacgtagta tacgggttta
      961 gcaggcgttt tatatttctc ctggataaag tcctggctgt tcttcaggat ctcagggcgt
     1021 agctccacgt taccgggagt gtacacacca tgcacgttac caaaggcggc agccacagta
     1081 aagcgggggc ctacctgtag cagggtttcg taggcaaaag ccacatcttc cggctgggta
     1141 tataatttgg cattgtcaac gccggagttg tccacaccat cttcttcacc accggttaca
     1201 cccagctcaa tttcgatgga catacccagc ttattcatgc gctcaaagta tttcttggag
     1261 atctcgatgt tctcgtggat aggctcttca gacaggtcca gcatatggga gctgtacagg
     1321 ggctggccgg tttgtttcat gaaagcttcg ccggcatcca gcaggccgtc tatccagggc
     1381 agccattttt ttgcagcgtg atcggtatgt aaaactaccg gtacgccgta gtatttggct
     1441 acttcgtgta catgtttggc gccggataca ccaccggcaa tgttagcctg caatttgtca
     1501 ttcggcatgc ctttacccgc aaagaactgc gcaccaccgt tggagaactg gataattacc
     1561 ggagagttca ccttggcagc ggtttccagc actgcgttca cggagttggt acctaccacg
     1621 ttcacggcag gcatagcaaa tgcgttgtcc ttagcatcct tgtacagcgc ttccagctct
     1681 tcgccgaata acacgccggc tctgtatttt cccatatttt atgattgttt actgtttacg
     1741 gagggcaaat atagtaggaa aaagcagaaa gcgcaaagca taaagcagaa agcccgaaat
     1801 tagggccgag cgctggaggc ggaatgctta acgctgatga ccgggtagct ggaggcaaaa
     1861 aggcagaacg tggaaggctg tgctacgggg gaaaggggaa agcataaagc cgaaggtaaa
     1921 aggacttaat gcggaatgca gaacactgaa agcccggaat agaacatgga gcgcttaacg
     1981 tcaaaacttt ccaaagacca gataagctac aaattaaggc ctccccggat gatgccagtt
     2041 aatttaaata acagcacacc ggtaaccagt cttaccacca gataaccgcc acaaacaact
     2101 tgcaacaagc gccagcagtg ttttgtcatc agcacatgca cacaacaaac aaaagtaaac
     2161 ccacaataaa aacaccatca gcatccggtg ttcaacgcat ttgcatatca aaagacaagc
     2221 ctcaaaaaaa cagaagcagc gttcagcgtt cggccttcag cattccgcat actaaagcaa
     2281 aacacaatca gctttctgct ttatcctttc agctttccgc ttaaaaaaaa gccgcaggca
     2341 gaagcctgcc gggcttttta tatgtggctg gtttgtcgtg caaagaattt atcagctaac
     2401 acttaatgtg ttcccgttaa tagacaccgt catcttggga agtgcagcag ttgcggggcc
     2461 tgtctgcaca gcgccggtgg tagtataccg gctgccatgg ccgcagggtg cattacattc
     2521 tatcaggtcg ctgccagtgt taaaggtaga aacagtgcag ccctgatgag tgcaggtgct
     2581 ggacagggca gagaatgccg acggcgtatt gcctgctgca atacggatca ggatcacccc
     2641 gccgcctatt ttaaaattgc cagtgtttaa cagttctgtg ctcaggtctg cggtgagctt
     2701 ggcgtttccg ccaccgttat tattatccgg cgcatcggcc atatgttttg tacaggcggc
     2761 taaccctccg gcacatgcga gtgccatagc catactaaga tggcttacaa agtcccttct
     2821 ttccattttg gtcgtacgtt tagtgaaaga attaagcgtg attgaatagg aataaatgtg
     2881 tttatatata gttacgtgga gtgatcataa aaggttgcct gttgagccag gatatgagga
     2941 ggagtgcagc agctcccgca aatactccgg tgcttccagt aagcggctgc cataccagga
     3001 gaacatttcc ccatccacca gccgtatttg tgcgccgggc agcacggcct gtatttctgc
     3061 tatatgctgc tccttaaaag ggtagggctc tgaagaaagt aatattagct gctgtgccgg
     3121 gggcacatct ttaaaaagcg tcgttaactc ctccagcgta actgccgggt accggggcat
     3181 atctgccagc acattcgtta aaccacatgc agccagcata tgatgaatga aagtatctcc
     3241 gcccgccacc atccatggat tacgccagat aaaataagca gcatgcaatt ccgtaaccgg
     3301 taaggcttca tgcaaaccct taaactgttc ctggatctgc atgctcaatg ccagtccctg
     3361 ttttgcatag ccggttattt cacccacccg ccgtatcatt tgcagggcct catccagggt
     3421 atgaatatca cttacccaca cgggaaattc catctgcagg gcagtgatct gttcctgctg
     3481 gttttcttct ttattggcga tgatcagatc gggctgtaag gcccttatct tatccaggtc
     3541 cagcgttttg gtgccgccaa tgcgcgtttt attgcggaac cactcttccg ggtgtacaca
     3601 aaacttcgtg atgcccacta cttcttcctc caatcccaaa tgatacaaca gctccgtttg
     3661 cgatggcaca accgatatga tccgccgcgg ccgcgcagga atggatacct cgttatgcaa
     3721 ttgatctatg tgaatacggt agcccatggg aggatggaat tacgaattac gaattgagta
     3781 gatcgtagtt ttaaaatttc gcctaattca agacaattca atacattgtt ttcaaccact
     3841 tcaatccagt cataattagt tacaatttat tttcgataac gttcccacta aggccgggca
     3901 ggctataaat gcttcatatt taataatcag ctgaatcaac tcctgataat catcccctgc
     3961 attccaattc gtaattcgta attccataat tcgtaattgc ctcagctccc cagtgcctga
     4021 ataatatcat acttcgtaac aatatgccag ctgccgctat catccttcgt tagcacagcg
     4081 ccattctctt tgttaatata caccgccagc ttttcaatag gcgtatccat gctcacttcc
     4141 gggaaagctg catgcatcac ctgtttcacc ggtgcatctt tcaggtttac atcatccatc
     4201 agcttattaa ataatccgcc ttcggaaata gcgcctataa tgtcaccgtt atgcagtacg
     4261 ggaatatgct ctatttcaaa cttcttcatt ttggcaatgg catcgctcac tttctcttcg
     4321 ccgccaatgg ttaccagtgg caggttgcgg cggccgttca ccacatcttt cacggttttt
     4381 acatccagga aaccgcgctc catcatccac tgatcattat agatcttgcc tacataacgg
     4441 ctgccatgat cgtggaatac caccactacc aggtccgttg gtttaagctg cgctttcagc
     4501 tgcagcaggc ctgctatggc agaaccggcg gagtaaccca caaaaatgcc ttcttccttg
     4561 gcaatgcggc gggccataat agcgccgtct ttatccgtta ctttttcaaa gtgatcaatg
     4621 taccgcatgt cgtagttctg cggcacaaaa tcctcgccaa taccctcggt aatgtaagga
     4681 tacacttcgc tcatatcaat ttcaccggtt tcatggtatt ttttcagcag ggagccatag
     4741 ctgtcaatag cccatacttt aatagccggg ttcttttctt tcaggtattg tcctgcgccg
     4801 gttacggtgc cgccggtacc ggtagctacc accaggtggg taaccttacc atcggtttgc
     4861 tcccatattt ccgggccggt ttgctcataa tgcgcatccc ggttagccag gttatcatat
     4921 tggtttacgt aaaaggagtt cgggatttct ttggataagc gccgggccac agagtagtag
     4981 gagcggggat cttccggctc tacattcgtg gggcatacga tcacttccgc acccaccgcc
     5041 ttcaggatgt ccattttttc tttggactgt ttatccgtag tagtaaaaat acatttatag
     5101 ccttttatta ccgcagccag cgccaggccc ataccagtat tgccggaggt gccttcaata
     5161 atggtgccgc cgggttttaa caggccctgt tgttctgcta cctccaccat ttttaccgcc
     5221 atacggtcct taatggagtt gccggggtta aaaaattcca cctttgccat tacggggcag
     5281 ggtagcgctg ccgttacacg gtttagttta actaacgggg tatgacctat cgtttccagt
     5341 atgttgttac agaattgcat agcgtgatat taatattgca gcgaaaataa gggaaaaaat
     5401 cggggcagga ataaagggca tggcgcatta aacaacaatc atccgttatc tttgcgcgtt
     5461 atgagtaacc ggatattcat tacaggcata ggcaccggtg tgggaaaaac cattaccgca
     5521 gcctgtgtta cgcaagccct gggggctgat tactggaaac ctgtacaaac aggattgctg
     5581 gaaggcacgg atacgcaaac cgtgcgtgcg ctgctgtcca ataccacctc tgtatgccat
     5641 aaagaagtat attgcctgca ggagcctgca tcgccgcacc tggccgcgcg gctggaaaac
     5701 gtgaccattg atccggccct tatcctgcag caggcgtcta ttatacaacc gcctcagcgc
     5761 agcctggtaa tagaaggcgc cggcgggtta atggtgccgc tgaatgagga cgtgtttacg
     5821 ctggacctca ttcgtcagct gcaggctaaa gtgattattg tggcgcagaa ctacctgggc
     5881 agtattaacc actccctgct taccgcccgg gtactacagg ccagtgatat accggtgctg
     5941 ggctggatct tcaacggcga tcatcattcc aatgaagagg atgttgtgcg ctggagcggt
     6001 tatcctaagc tgggccgcat accgcacgcc actgtggttg atgctaattt tattgcctta
     6061 caggccaaac agctgatgtt ttaaataagc acacacaaag taaaccgatt gttcactaaa
     6121 acggatatac gaaagcagtt cctggaacgc cgtcttaaca tgccggcaga ggacgctgct
     6181 gcacttaacc agcacctgct ggaaaactgt caaaaggtga attatagccg cattcgctgg
     6241 gcgcacatct ttcttcccat aacagaaaaa aaggaggtga atacctggcc catagtaaca
     6301 tggatgcgcc aggcttatcc ggccctgcaa tgggtgctgg gcaaggcttc cctggccacc
     6361 gccgacatgg agcatttcct gtgggaagaa catacccctc tggttaaaag ccgctatggc
     6421 ataccggaac ccgccggcgg catacccgtg gaacccggta cgctggacct ggtatttgta
     6481 ccgctgctgg cctttgacct taccggtcat cgcgtaggtt acggcaaagg catgtacgac
     6541 cgctttctga aacaatgccg gccggatgtg cgcaccatcg gcctttccct gtttgagccg
     6601 gtagatgtga tcatggatgc cgatatccac gatgtaccgc tgcaaaccgt tattacaccc
     6661 gttactatct atcaatttat tgaaaaacaa tgaaagtact gcgatacctg aaattcctgc
     6721 tttacccctt ttccctgcta tacggcctgg taatgtggat acggaaccgc ctatacgatg
     6781 ccggcaccct taccgctgta agttttgacc tgcccattat tgccgtgggc aacctgtctg
     6841 taggcggtac cggtaaaacc ccgcatgtgg aatacctcat acgcctgctg aaagaacatt
     6901 ttaccatagc caccctcagc cgcgggtata accgccgttc caggggctac cagctggcca
     6961 gtgagaacag cacagctgcg cagctgggcg atgagcccat gcaatttcac cagaagttcc
     7021 cggatatcag cgtatgtgta ggtgaggagc gtatgctggc cattccccag ctgttaggcg
     7081 aaaaaccgga aacccaggtc attctgctgg acgatgcctt tcagcaccgc tccattaaac
     7141 ctggcttcaa catcctcgtt actgaataca accgcccctt tacccgcgat catgtggtgc
     7201 cttttggccg cctgcgtgag gggcgtaaag gttatgagcg ggccagctgc attattgtat
     7261 ccaaatgccc gcccaatatg ggagaaacgg aaaaacaggc cctgcagcgg gaaataaatc
     7321 ccctgccgta ccagcgcctt ttctttacca gcctgcaata cgggcagccc tatgacctgt
     7381 tcacccaggc gcctatgctc ataagcccgg atgctacttt gctgctggta tgcggtattg
     7441 cccgcccggc ccccctggta caacatttaa aagagggttt taaagaggtg ttcctgctgc
     7501 ctttcccgga tcattattac tatagcaata acgatctgga aaagataagc aaagagctga
     7561 aagacttacc cggtgcggaa aaggtggtga tcaccacaga aaaggatgcc gtgcgcctgc
     7621 acctgttaca ggagcgtttg caggagttga acctgcgcat agcagtgata cctgtggaaa
     7681 tatctttgct cttcggcgaa gggaattcat ttaataatta tatttttgac tatatcgtgg
     7741 ggactggaac atcatatatt agaacttaat gggacatgag atgaataaaa agaaaaaaca
     7801 aaaaaaaggc aatcacagtg gcccgaagaa gacttttcgc gggatgattg aagtgacgcg
     7861 ttcgggaatg gcctttgtaa tagtagaagg attaacaaaa gatatactgg taaaacagaa
     7921 gaacctgaat accgcgctgg atggcgatga agtgctgtta gatgtgctta aagaccactc
     7981 caataagaac aacggccgta tggaaggcgt ggtaacggac atccttaaac gaaagaaaac
     8041 agaatttaca ggcaccctgc aggttaacaa aggctttgcc ttcctggtac ctgaaaaggg
     8101 cgctttttta ccggatattt atatacctgc caactcactg ggcgaagcca aaaccggcga
     8161 taaagccgtg gtacgcgtag tagcctgggg cgaaaagacc cgcaagccgg tcggcgagat
     8221 catagaaata ctggatgcca gcgataccaa cgacctggcc atgaaggaaa tactggtgga
     8281 aagcggtttt ccgttgtcgt tcccggatga ggtgatagcc gagctggcag agatcaagga
     8341 gaagataacg gccgcggaag tacgaaaaag aaaagatttc cgcaaacagc tcacctttac
     8401 tattgatccc gtagatgcca aggactttga cgatgccatt tccatccgca aaataaaagg
     8461 cggttattat gagataggcg tgcacattgc cgatgtaagc cattatgtgc tgccggatac
     8521 tgcgctggat aaggaagccg ataaacgcgc tacctccgta tatctgccgg accgtgtact
     8581 gcctatgctg ccggaaaaga tctccaatga gctgtgttcc ctgcgtccta atgaggataa
     8641 gcttactttc tccgccgttt tccagatgaa tgaaaaaggc gagatcaaac agcactggct
     8701 gggccgcacc gtaatccatt ccgatcatcg ctttacgtat gaagaggtgc aggagatcat
     8761 tgaaggcaac agcgaagggc cgcataaaga agaagtgatg ctgctgaata aaatagcccg
     8821 cattctgcgt aaaggccgtt ttgatgaagg cgctattaat ttctcctcac aggaagtacg
     8881 ctttcagctg gaccctgacg gcaaacctat tggcattgtt attaaagaaa gcaaggaagc
     8941 gcaccagctg atagaagaat ttatgctgct ggccaaccgt acggtggcgg agtatgtatc
     9001 taaaataaag gtcaataagc aatccgttcc tttcccttac cgtgtgcacg acacgcccga
     9061 cgaggaaaag ctgcaggtgt tttccatctt tgcccgcaag ttcgggcaca agtttgacct
     9121 ggataacccg gaccatattg cccgttcttt taacaagatg ctgcagctgg ccaagggtaa
     9181 accggagcag catgtgctgg aaaccatcgg catccgtacc atggccaaag ccatttacac
     9241 accggataac attggccact atgggttagg atttgcgcat tactgccact ttacctcccc
     9301 catacgccgc taccccgatg tgctggtgca ccgcgtgctg gcacaatgcc tggcagaaga
     9361 tatacacccc gacaagtaca tggaaaagaa gtgccgccac tgctctgaaa tggaacgtaa
     9421 ggccatggaa gcagagcgag ctgccaacaa atacaagcag gtggagtaca tgcagcagtt
     9481 tattggcgat acgtttgacg gcgttatcag cggtgtggcg cactttggtt tctgggtaga
     9541 aactattgat acaaagtgcg aaggcctggt aagcattcac aatatgatgg cccgtgatga
     9601 gtttaagcat gatgaaagcg aatatgccct ggtaggcctg cacaccggcc gccggttccg
     9661 tataggcgat aaggtgaaga tccgtgtaat gtcggctaac ctcaccaaac gccagctgga
     9721 ttacgacctg gtagaagacc tggaagaaca gcagccagcc tccaggcccg gcaacatcgg
     9781 caagcccaaa cgcaaagaga aggaaaagga aagaggagag cgggtgcagc agggaccagg
     9841 taaaaaaccg aagcctaaca agcccggatc caaacctaaa cctaaagccg cagataataa
     9901 taatgccagc aaacctgcga aagcaaaacc acggccccgt aaaaaggaat tataattttg
     9961 ctttgatcaa tatatccgac ttcagacttc attttatacc atgcactctt ttcaggaact
    10021 tatagcacaa tttatccagc aatttgatca gcaacgtttc cccgaccaac cttctacgct
    10081 gtataacgca gcctcccaca tactgaaaat aggaggtaag cgcatacgtc cggtattggc
    10141 ccttatggga aatgagctgt ttgataccat tcatgcagat gcctggcagg taggcaacgc
    10201 cgtagagctg ttccataatt tcaccctcat tcacgatgat attatggaca aggcgccgct
    10261 acgcaggaac aaccctaccg tacacaccct ttatggcgaa ccggccgcta tcctggcggg
    10321 cgatgccatg ctcatatatg tgtatgaata cctgaaccgg gtgcagtcgc gctacaaaca
    10381 aaagatcgta tccgtattta accgcgctgc catacaggta tgcgaagggc agcagctgga
    10441 tatggatatg gaagctatgg acccagccca ggtgaagtat gatgattatg taagcatgat
    10501 agccctgaaa acgtctgtac tgctggctgc atccctgcaa atgggcgcta ttattggcgg
    10561 tggcagcgaa ggcaaccagg gctacttata tgaatttggt aagaacatag gtattgcctt
    10621 ccagatccag gacgattacc tggatgcttt tggcgatccg gaaaagtttg gcaaacagca
    10681 gggcggcgat atcctggcta ataaaaaaac cttcctgctg ctgaaagcat tggagctgtg
    10741 caaccctgca cagcgtatcc gcctgcagca gctgttggat actgccccgg atgataaagt
    10801 agcgcaggtg ctggaactct tccacgactg tagcattgat agctgggccg aaaaggaaaa
    10861 agaacgtttt cagcaaaagg cgttcgacaa cctggaaagc atcgccgtat tatcttcccg
    10921 taaaaagccc ctgatggagc tggccgattt ccttttaagc cgccagcatt gagattttag
    10981 atttggggat ttacgatttt agatttattg gagcgattgg gggaaatccc ccaaatctaa
    11041 aatcgtaaat ctaagatcgt aaatctgatt atattcgcag atcaccaaaa ttgaacttgc
    11101 tttgtctaag tcgttattcc gcaggaagtc attatccact atacttaagg atgcaaggga
    11161 agggttaaca gacgcgcatg gaacaggatc tctgcacagg gtactaaaag taaaagacct
    11221 caccgctatg ggtattgccg ccgtaattgg cgcaggcatc ttctccacca ttggggaagc
    11281 ctccttccat ggtggtccgg gcgtatctgt cctgttcatt atcacggcca taacctgcgg
    11341 tttctctgcc ctttgttatg cggaatttgc atcgcgtgtg ccggtatccg gcagcgccta
    11401 cacttattca tatgtaacgt ttggtgagct ggctgcctgg gttatcgggt ggtcgctgat
    11461 cctggaatat gctattggaa acatagccgt tgccatttca tggagcggct attttaataa
    11521 tttattgagc ggtatcggtt tgccgctgcc cgggtggctg atcagcaatt acgacaatgc
    11581 taccccggaa accctggctg ctgccccgca tatcggcagc attcccgtta tagtgaacct
    11641 gccggctttc ctggtggtgg tgttcattac ctggctggcc tatgtgggca tccaggaaag
    11701 taagcgcagc gccaacttca tggtggcatt taagatcctg gttattcttt ttgtgatagt
    11761 gctgggtgct ttttatgtga atacagataa ctggcatccc tttatgccta acggtttttc
    11821 cggtgtgtta aaaggcgtgt ccgcggtgtt ctttgcctat attgggtttg atgccgtaag
    11881 cactaccgcg gaggaatgta cgaatccgca gcgcgatctg ccccggggca tgttctactc
    11941 cctgatcatt tgtaccatat tatacattct tatttcactg gtgctgaccg gtatggtgcc
    12001 tttcactgag ctgaaggtat cggatccgct ggcttttgtg tttgacaggg tgaacctgaa
    12061 atgggtcagc tatattattt ccgtgagcgc cgtaattgcc accaccaccg ttttgctggt
    12121 attccagatc gggcagcccc gcatctggat gagcatgagc cgcgacggcc tgctgccaaa
    12181 gcgtttcagc aaaatacatc cgcgctttaa aacaccttcc tttgccacca tcattaccgg
    12241 catactggta ggcgtaccgg ccctgttcct gaaccttact attgtaacag accttaccag
    12301 catcggtact ttattcgcct tcatactggt atgcggcggc gtattgctgc taccccgtga
    12361 ggagagcaat acccagcggt ttcagctgcc ctacattaac gggcgatgga tcgtgccggg
    12421 gctcattgtg ctgttcatta tcctattcca tacccagata caggaaaagt ggtcctttgc
    12481 cggtggctgg gatgtttgga agcataacat acctttctat ctatttacca tcgtagcaat
    12541 cctgatcact gtattctcat tcctccgtaa actgtcactg ataccggttt taggcctttt
    12601 aagctgtttt tatctcatga cagagatggg cctcaagaac tggatcgttt tcgctatctg
    12661 gctcctcact ggcctggtga tctatttcag ctacagctac cgtaatagta agctcagcac
    12721 ggctgaagca tagcggaaag cagaaagcgc aaagcataaa gcataaggca caatggcttg
    12781 gccttcatcc gcttcttcct tgcagatcca aacgacggac ctttgcccgg cgccacacgc
    12841 ttgataaagc tccatagcac accaacgccg gtatgcttcc tcatgcctca tcatcatcca
    12901 aacaggcggg cgcagtctgg agttggagct gtaaggatga aacgccaatc aatcaaacca
    12961 gaacaaagat acccgcccaa ccgccaagcc tgtcctgaat gcgctccttt tttcgtaact
    13021 tcagtacagt agttctttga tcctaaaact gaatgttatg aatctgctac agaaaattga
    13081 gatctggggc gacaggcacc atcccaagtg gctggatgct gtacgcattg gcttaggcat
    13141 tttcctgttc tggatgggcg ttctgtttgt gcaaaaccgc gatgcactaa ccgccctgat
    13201 caacgaaaat ccaacattaa cagtcgtatc cttctggctg gcgcattaca tcgtgtttgc
    13261 ccacctggcc ggcggcgtgc tcattatgtt gggatcgtta accagactgg cagtattagt
    13321 gaacataccg gtgttaatag gagccgtgtt ctttgtacat tcccctacag ggctgtttgc
    13381 agtacacagc attcccggca tttccattgt agtcctgtta ttgctggtct ttttcctgat
    13441 agaaggcagc ggccctcttt ccgtggatga atatatgcgg aggcaccccg cctgacatat
    13501 aggaaatccg attttagatt tacgatttta ccatttagat ttgaggttcg gataaagaga
    13561 atgtaaactt caaatgtaaa agcgcagcac ggtcaaagtg tagtcaactt ttacgtttta
    13621 cattctccca aagcatcgta atctaaattg tcaggggaga gaatgcaatc atgaaatatg
    13681 aaataggcga taagatcatc ttactccatt caaaggagga gggcaccgta gtggatattg
    13741 tgaaccggga aatggtaatg gtggaagttg gtaagaccac tttccccgta taccttgacc
    13801 agatagactt cccatacttt taccgtttta cggaaaagaa gctgcctgca gcagcgcccc
    13861 gcaaggtacc cggtgacgag ctccccgtag aaaagaaaaa gcacgaaact ttcaaaacag
    13921 ataaaggcat gttcctttcc atactgccgg tataccaggc agatggttat gaggaaaata
    13981 tacagctgct gaagttccat ttacttaatg aaacccagcg cagctacacc ttacacttcc
    14041 gcgtgtggct taaacaacag ctggacctgg aaattaagaa tgatctgcag cccttcagcc
    14101 acttttacct gtcggacctg ttatttgaat ctttgaacga cagcccgcgt tttgaattta
    14161 ctttttaccc aagagagaaa gacccaaagc tggcgccttc attcaataag gtctggaaaa
    14221 taaagcctaa gcaattattc cagcagctca atgagctgca tatacgccgg gatgccatgc
    14281 tgagcttccc gctgtttgag aagtaccccg acaaacaacc cgatacccgt tacggttttg
    14341 aagcggagga tatcagcaaa ttatcgccct tatacagtaa gatacagctg gcgcccgatg
    14401 cgcccctgga gccaaaatat gaagtagatc tgcatataga aaagctcatt gatgagtggc
    14461 ggggcttaag caatatagcc atcctggcca ttcagttaaa tgaatttcag cgttatcttg
    14521 acctggccat tgcgcataaa caaccaagca tgatcgtgat acatggcctg ggcaaaggaa
    14581 agctgcgcga tgaaattcat cagctgctgc ggcaaacccc ggaagtaggc aattttgtga
    14641 acgagtacca tccccggtac ggatatgggg ccacggagat atcctttaaa tattagtaac
    14701 tttaacgcga ataacgtaaa ctacaaaccg tgctatcgtc tttcccgtta aacggaagga
    14761 aggaaagtcc ggacagcata gggcaacgca ccacctaacg ggtgggatcc cggcgcaggc
    14821 cgggatacag acagtgccac agaaaataac cgccacggct tgccggggta agggtgaaaa
    14881 tgtggggtaa gagcccacgt tctgatatgg caacatgttg gaagggtaaa ccttgcgtgc
    14941 tgaaatgcca tgtatacggt cgtttgaggg ctgcccgccc gatgaccgag ggtaggcaga
    15001 tacaggtaac gcgtgagcgt tatcgcagat aaatgatagc agttccggtg caaaccggga
    15061 aacagaatcc ggcttacagg tttgtagttt tatgttattt gtttgtacct ataccgcagc
    15121 aaccaaacta aaacgcatat acttttatgg atcagaatca agaaagaacc tggggcgccc
    15181 tggtacacct gggcggacta atagggatgt tcatcttatc gtttgtagga aatattatag
    15241 gagccctggt aatgtggctc attaaacgca atgaatccgc cttcattgac gatcagggta
    15301 aggaagccct taacttccag atcactttaa gcctggtaaa tgtggccatt ggcctgctga
    15361 tcagcctgcg gcacggcatc tgggctttcc gttccatctg gcgcgatcat gattttgacg
    15421 gctggcatgg ctttggttcc gccatcagct tatacggcat tgtatcactc ctgaatatca
    15481 ttttctctat tattgcagcc gtacgcgcca ataaaggcat ccgctaccgt tacccgcttt
    15541 gcctgagaat agtgaagtag tttagtccat ggtctatggt cgatggtcca tagacttttg
    15601 cgcagatact agtataaacg agaagcgcta aatgaggtga attgatcact acatttagcg
    15661 cttctcgttt tatatatctt ttcgttctat gctatggact atggaccatc ggccatggac
    15721 tccaaaaatc accccttctt caccggctgt aacttaggct tgcccttctt tttatctcca
    15781 ttcaccatgc tgtctgccag ctgcagggca ttgtaagcat tcacaatacc accggttaca
    15841 gacaggctgc tgaacggtac tttttcttct gtaccgggtt tggttaccat gctgtctgtt
    15901 aaaggcgata cgcttttttc cagcaccatt ttcagctgct gcgcagtcag gctggggtag
    15961 taggagagta ccagggctgc tacaccggtt actaccgggg cggccatgct ggtaccgctg
    16021 gcgctgccgt acttgttacc accgggtaca gtagagtaga tctgcacacc gggtgcaaac
    16081 aggtctacct ctgttttgcc gtagttggag aaattagcca ctttggaagt gcggcgtccg
    16141 gcgccggaag cgcctaccgt gatcacgttg gtagcccggc tatgatcgtt ataatgtgcg
    16201 ctggggaagt tatccaccac atcattatca ctggcatcat tacctgctgc atgtatcagc
    16261 aatacgcctt ttgattcggc atatttaata gcatcatcta cccagtcctt attaggggaa
    16321 aatcctttac caaagctcat gttaataacc ttggcgccat tgtccaccgc ataacggatg
    16381 cccagggcca catccttatc acgctcatca ccgtccggta ccacttttac tgccataatg
    16441 cgtacgttat ccgctacacc gtcaatacct acgttgttat tgcgggcagc tgcaataatg
    16501 ccggatacgt gggtgccgtg gaaggcaaat tcgcccatta catcattatt gccgtagtat
    16561 ttgtcgttaa tatcgtctgt attatcgcct acaatttcct tgcgtttatc tacttcgccc
    16621 tcgtctgctc tttcagcttt cttcttcaga tcgtcaatat actcttcaaa ttctgattta
    16681 aagtccaggt aggctacgtt ctgctcgccg gtgctttgca gcaggcgggt cataaagttc
    16741 ttagccacca ttacatcctg gtcagtagtt tctatactat ccaggcgcgg accgttaaag
    16801 tcatcctgtt tcaggtaagt ggtcaggatg ttggcgcact tcagcatgtt atcatgcagc
    16861 ttggtcatgg tgcggtaaga ggctttatac tggctggtag gttttacaac cttctccacc
    16921 agcttttgcc agtaggcata ttcccgggag ctgcgatcca tggtagaatc cgggttgccg
    16981 taaatgcggc ggtaacgcag gtattcgcgg gtagcttcat cagaggcttc ctttacgctg
    17041 cggccgtctt taccgcccag gaagttccag ccgtgaatat catccacata accattacca
    17101 tcatcatcta tgttgttacc gggaatttcc tttgggttgg tccaaaggat ggatttaagg
    17161 tcctcatggg tagtatcaat gcctgaatct attacggcta ctactaccgg tgtgctcttt
    17221 ttgcctttta atagctcttt gtaagctttt tctgcgccta ttcccaacac actgtccttg
    17281 tcatagctta ataagtgcca gttcctggga attgatgtgc cttgtgcaaa tgtgctgatc
    17341 gaggctgtca ttagcacaac acttcccgcc agtacggcca ctgctctgcg tacaatcatt
    17401 taaattttat tttaagtcag atggaacctg gtattataaa caggttctca atgaaaaaca
    17461 cttgtaatat aatacaggta aataaacgtc ttatcataaa caatttaaat accatatttg
    17521 gttaaagata tgtaaaatgg aattactaca agacaacatt ctgacgagcg ttcaaaaaag
    17581 ctgatcactg acaagcgaat tgcaaccgcg ctttttaatt gcaaaaattc ttgctttttt
    17641 ttccatatca gcattgttga aactcattca atacctcaga taaatatcgg caagcagtta
    17701 ataaccaata tattaaaaaa aagaaagggc tctgcctgct tatttgatat taaatgcgaa
    17761 gtgaaaaaat aggactttta gaacccacaa ggaaggatta tagcacaaaa gtagaatatg
    17821 aattgtcgga aaaaagtata atatttattg ctagaagaat gtttgaaagc catctcaggc
    17881 tgacagacgt ttttctcata agcatggttt ccgtttaacg aaaaagcgag gttctctaac
    17941 ctcgcttctt ttttttatag tcatatatac aaagggaaaa aatcaaacat ctaaaacgcc
    18001 caggatcact actttattgt tgagtttgca ctattgttat taagcggctt acaaaaatta
    18061 aaatattata tatattattt agtttaatgc aattgcagtt ttgttgcaaa gcagcctatc
    18121 gctggaagaa aggcattttg ttcccgtata gggctctccg gtagagcctt gcaggaagca
    18181 gagagctgag ttcttaagca tgcctccagc agcttcggat tcaacttcaa ccggtataat
    18241 cttgccggta gtacctccct aaaaagcctg gcgccggagc catgtgtttc gcacacataa
    18301 ctccggcgcc aggccattaa aaaacatatc attacaggtc aaaagaaata ccctgtgcca
    18361 gcggcaaact gttggaatag ttgatcgtat tggtttggcg gcgcatgtag ttcttccacg
    18421 catcggagcc gctttcgcgc ccgccgccgg tttccttttc accgccaaag gcgccgccta
    18481 tttccgcacc cgaagtacca atatttacat tggcaatgcc acaatcggag cctgcgctgg
    18541 aaaggaactg ttccgcctcc cgcaggttca gcgtcataat agcagaggaa agcccctgtg
    18601 gtacgccatt ctgtatgtca atagcttctg ccagggtttt gtatttgatc acgtataata
    18661 taggcgcaaa cgtttcatgc tgcacaatgt caaaatagtt ctgtacttca gcaatgcagg
    18721 gctgtacata acagccggat tcaaaaccct ttccttccag cacgcggcct tctaccagga
    18781 aacggccgcc ctgctttgtt acctgttcca gggcctgctg gtaggcctgc acggcctgtt
    18841 tatctatcag tgggcctacg tgattatttt catttaacgg gtcgcctata cgaagctgtt
    18901 tgtaggcatt caccagcttt tgtgtaaaag catcatacac actttcatgg ataatgaggc
    18961 ggcgggtaga ggtacagcgt tgtccggcag tacctacggc gccaaacaca catcctatga
    19021 gcgacatatc caggtcggct gcctcagaga taataatggc attgttgcca cccagctcca
    19081 gcaaagccct gcctaaacgg gcgcctactg cgctgcccac ggccttaccc atgcgggtag
    19141 accctgtggc ggataccagt ggtatacggg tgtcatgtgt taaccattca cccacctcac
    19201 ggccaccggt taccaggttg caaacccctt ccggtacctg gttggcggca aatacgcttt
    19261 gtacaatatg ctggcatacc aatgcggtaa ccggtgtttt ttcagatggc ttccagatgc
    19321 atacatcgcc gcatacccag gccagcatgg cattccagct ccatactgct accgggaagt
    19381 taaaggcgga tataatgcct accaccccca gcggatgcca ctgctcatac atacggtggc
    19441 ccggcctttc agagtgcatg gcaagaccgt agagctgccg ggaaaggccc acggcaaaat
    19501 cacagatgtc tatcatttcc tgtacctcgc cataaccttc ctgcaggctt ttacccattt
    19561 cataggacac cagcttaccc agcgatgttt tatgtgtgcg cagcgcttca cctatctgcc
    19621 gcaccacctc gccacgtttg ggcgcgggcc actggcgcca ttctttaaaa gcctcttctg
    19681 cagcggctac caccgcatca aactccgctt tgctgccgct ttgcacctgg gctatttcct
    19741 ttccatcaac cggggaaaag gagctgagca cctcaccttc gcctttcagc cagtgtttac
    19801 cggtgcttac cccgctatgc cgggccggta tattaaattc tttcaggata tctgctatca
    19861 tgggttgcaa tttaatgatt atttagtcca tggtccatag tcgatggtcc atagcatgtt
    19921 gcacagtttc ctgtgctcca gtgatattac ttgtaaagct accttacgtt caaggccatg
    19981 gaccatcgac tatggaccat ggactcaact atctccccgt ttgcgaacta tacgtactct
    20041 caaagatctt atccgcatta ccggcttcaa aaccatcccg gcggtgttcc cgctttacct
    20101 ggtctgtggg caggtgtgcg aattggggta gtacctttct ttctgcaaac tccacataag
    20161 agccggcaat ggggtgcgtt tcattattgg caaatgtggc ggtgatcata ttggctaccg
    20221 tagcgctttg cagcaggccg ccatcagggc ttaccttcat tttgccgccg gcattgttca
    20281 gggtaaaacc tttacgctcc aggaaagcat taaactcggg aatggtatta taacccgggg
    20341 gcaggttatg tacgctgata gtaaagtggt tcaggtaata acggttgtaa atgacccagg
    20401 cggcatactc gctttcagct gccagcagct tataatcctc cagggtaggc aggcgccata
    20461 agccactgtg caggaaacta tctactgcac tggcatcgtc caggttcagg gcatctacgg
    20521 gatcggattt aacttcatta gtgtagctcc ggataagctc ctgtgccttc gggctcaggt
    20581 cctgcacgcg cagctcactg ataaaaatgc ggggaaaatg aggtgcaggc ggtgcgtacc
    20641 agaaagcatc cagctttttc tcggggaagt ggtaggcgct ttttttcgtg tagccgtaat
    20701 gcaggaagat cttttccagg gattgtatgc ccagctgcgg cacgcccatg gtccggaatg
    20761 caatatggtc attttccaca tcttccggct ttgcaataat accttcctgt atcatggctt
    20821 gtataatggc ctttacatcg ggcacccgct ccatgtagcg ctgcataagg ccgctgagta
    20881 cttgctctag catagcgtgt tcaattacga attattcaat tacgaattac gaattgcctg
    20941 cgttttgttg aagagcagtt ttttcattcg tg
//
