LOCUS       NZ_FOBB01000005        10831 bp    DNA     linear   CON 22-OCT-2024
DEFINITION  Chitinophaga rupis strain DSM 21039, whole genome shotgun sequence.
ACCESSION   NZ_FOBB01000005
VERSION     NZ_FOBB01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Chitinophaga rupis
  ORGANISM  Chitinophaga rupis
            Bacteria; Bacteroidota; Chitinophagia; Chitinophagales;
            Chitinophagaceae; Chitinophaga.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900109685.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 15:41:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,474
            CDSs (total)                      :: 6,410
            Genes (coding)                    :: 6,392
            CDSs (with protein)               :: 6,392
            Genes (RNA)                       :: 64
            rRNAs                             :: 1, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1, 1 (16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 18
            CDSs (without protein)            :: 18
            Pseudo Genes (ambiguous residues) :: 0 of 18
            Pseudo Genes (frameshifted)       :: 4 of 18
            Pseudo Genes (incomplete)         :: 13 of 18
            Pseudo Genes (internal stop)      :: 2 of 18
            Pseudo Genes (multiple problems)  :: 1 of 18
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:12:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 344861
            Orig. end                         :: 355692
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FOBB01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10831
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10831
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10831
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5831](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5831
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(560..1189)
                     /locus_tag="BMZ54_RS20895"
                     /old_locus_tag="SAMN04488505_105287"
     CDS             complement(560..1189)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013098.5"
                     /locus_tag="BMZ54_RS20895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105287"
                     /product="VOC family protein"
                     /protein_id="WP_089916772.1"
                     /transl_table=11
                     /translation="MIPNIECSQLFPTLLVKDIPSAIDFYVNRLGFSHRFSWGDPPTFA
                     GVGLGQVNLHLQKGESFVDGASEVCFITENAEELYELHQANGVEIIVPMEDREYGIRDY
                     RVKDADGNSLVFGRYIYNQGPPIKIERVDVPVRLEKRLAALLQDLAEHKRMTVSSCLEE
                     TLLHTFERVGDSVASPHTVGTLNYIQALKKKHNIDYDTHGSYRFVE"
     misc_feature    complement(1311..1329)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.76"
                     /tool="antismash"
     misc_feature    1314..1332
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 22.84"
                     /tool="antismash"
     gene            complement(1569..3275)
                     /locus_tag="BMZ54_RS20900"
                     /old_locus_tag="SAMN04488505_105288"
     CDS             complement(1569..3275)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179: hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014217857.1"
                     /locus_tag="BMZ54_RS20900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105288"
                     /product="HAD-IIB family hydrolase"
                     /protein_id="WP_089916776.1"
                     /transl_table=11
                     /translation="MRYYVLASDYDGTLAHHGGVTDEVVEALKALKASGRSLLLVTGRE
                     LDELKALFPAHTVFDRIVAENGALIYNPATLEETTLGDAPPEAFVAELRKRGVQPLSAG
                     RVIVATWEPHQDTVLEVIKQFGIERQIIFNKGAVMVLPPGINKSKGLNAALDAMGFSMH
                     NVVAVGDAENDSAMLQVAECAVSVANALPTLQKISDWVTPADHGEGVMQLAARMREDDL
                     LTLDSVLKRHYLPLGDRYDNAPFLVSPYGSNIILAGSSGGGKTTFTAAFMEILLQRGYQ
                     FIMIDPEGDYLELQGTVTIGDVAQPPALEPLMQLLDRPHQSVIVCTLALSMEEKPAFLQ
                     QLLAAVLELRQHKGRPHWILLDEAHHLAPAEANPHFFTPLHAFTNYIAITTRPELLHQS
                     LLDQATTIMAVGQAPHETIHHYASCIKAALPEIPIADLQKGEALVWHRPSGEAPFLIRT
                     LVPQKILQRHKRKYAIGDMGPDSFIFTGPEAKLQLKASNLLRFVEIAEGVDDDTWLYHL
                     QRHDYSAWMRNSVNDETLAEQVEKIEDKEPDAAASRDAVAQLVKLHYTGPA"
     gene            3430..4011
                     /locus_tag="BMZ54_RS20905"
                     /old_locus_tag="SAMN04488505_105289"
     CDS             3430..4011
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="BMZ54_RS20905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105289"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_089916780.1"
                     /transl_table=11
                     /translation="MSAAKGAVTGHHAIIREWVQLYTNGMYAWAYHKTTDKALAEDLVQ
                     DTFLAALQSFDKFKQESQPKTWLFSILNNKISDHFRQQFRHPVVNEAEGGLSFFFDEED
                     EWRKERSPQAWNTTDTHILDNPDFRKILQHCMHLLPGNWLAAVKLKYLEEKEGKDICQD
                     LQITPSNFWQIMHRAKLHLRNCLEINWFKK"
     gene            4019..4294
                     /locus_tag="BMZ54_RS20910"
                     /old_locus_tag="SAMN04488505_105290"
     CDS             4019..4294
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BMZ54_RS20910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN04488505_105290"
                     /product="hypothetical protein"
                     /protein_id="WP_089916784.1"
                     /transl_table=11
                     /translation="MKRVLKKIFLPCTVATEMIEKDIYFKLSALEKLRLFLHTGLCGLC
                     HRYQKHSRLLHRILMELHHEHEHPQAPKEEEQTALKEKITNRLEKN"
     gene            4380..4712
                     /locus_tag="BMZ54_RS20915"
                     /old_locus_tag="SAMN04488505_105291"
     CDS             4380..4712
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BMZ54_RS20915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN04488505_105291"
                     /product="hypothetical protein"
                     /protein_id="WP_089916788.1"
                     /transl_table=11
                     /translation="MENKKKVLLTGSLLAGALLATANLQANAADLFSFNNLGTGEAVRT
                     RLMDGASHARTLELNCGEKKDSASMKKGKDGKCGKDGKCGEGKCGDKKGGKKKMKADSA
                     KAKPAK"
     gene            5001..5831
                     /locus_tag="BMZ54_RS20920"
                     /old_locus_tag="SAMN04488505_105292"
     CDS             5001..5831
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008584484.1"
                     /locus_tag="BMZ54_RS20920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105292"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_089916794.1"
                     /sec_met_domain="DUF692 (E-value: 3.6e-100, bitscore:
                     329.1, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGIGFRKDFATTLLQSPSFNPAFIEVAPENWIGVGGYWKKLFNQ
                     ALEKYPLYTHGLSLSVGSPDELDLNFLQKVKTFLRDTNAQIYSEHLSYSKCDNAHLYDL
                     LPIPFTTEAVRHVSRRIRQVQDFLERKIAIEIVSYYTPVAPELTEIAFINAILEEAGCN
                     LLLDVNNVYVNGFNHQYDAKAFIDQLPMDKVAYIHMAGHEKVSDDLIIDTHGEAIIDPV
                     YDLFAYTMQRLDRDVPVLLERDFNIPELDELQQEINRLQQIKNVHLKNPRYATA"
     gene            5818..6576
                     /locus_tag="BMZ54_RS20925"
                     /old_locus_tag="SAMN04488505_105293"
     CDS             5818..6576
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF046510.1"
                     /locus_tag="BMZ54_RS20925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105293"
                     /product="DUF2063 domain-containing protein"
                     /protein_id="WP_089916798.1"
                     /transl_table=11
                     /translation="MQLPETTHQHQSALADYCRTGKYSAIPGVREQHVTQYRRLVYNVV
                     DDMLQSAYPLTHHLLTTREWNALVQEFFSNHPCQSPQVWYMPKELYEYLSPKEHKLKNK
                     YPFLLELLWLEWLEVELFMMEDRPAAYTTIGDLSTDELVLNPEHHLQQFQYPVHLKTAK
                     QLTPADKGDYFLVLFRKPDSGEVNFMNLSPALVAMLEILQEGPQTMDALIRQCCAAWQL
                     QLSPEIQAAAHAFITQSLDNRLIIGFKSKH"
     gene            6576..7019
                     /locus_tag="BMZ54_RS20930"
                     /old_locus_tag="SAMN04488505_105294"
     CDS             6576..7019
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019301.5"
                     /locus_tag="BMZ54_RS20930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105294"
                     /product="DoxX family protein"
                     /protein_id="WP_089916803.1"
                     /transl_table=11
                     /translation="MSILSSYARTAASLEKARAVPLLLLRLVLAYGFYTPAKMKWSDIN
                     SIAQWFGSMHFPMPTLSAYLAAATEAAGVVLLTLGLATRLITIPLMIVVLVAIFAVHWP
                     NGFSAGDNGFEIPLYYFLMLFTLFIMGPGSISMDERLRRKYRN"
     gene            7049..8032
                     /locus_tag="BMZ54_RS20935"
                     /old_locus_tag="SAMN04488505_105295"
     CDS             7049..8032
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014218869.1"
                     /locus_tag="BMZ54_RS20935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105295"
                     /product="ion channel"
                     /protein_id="WP_089916806.1"
                     /transl_table=11
                     /translation="MALRINPFSKINNDTGFGSSSSGSVGRFVNKDGSFNLRKEGRPYW
                     ERMSLYHFMLNLSPLKFFCAILLFFFSINLIYTAIYLVLGAHEFVGIIGQTKWQVFKEI
                     YFFSTETFTTVGYGRVNPIGDGANLVASLEALNGFLYLAVFTGLIYGRFSKPKAFLMFS
                     DYAIIAPYQDKMGLMFRFASYKNNHTLTDVEVKVTAALLVTENGKTAFQFYDLPLERSK
                     IQNLPMNWTVVHPIDENSPLQGLNPEDLKAADLEIYVLIRAFDDVFSNFVLRRTSYTYE
                     EIKFNRRFVPMYRETGTSTILELHKLSDSKEVDVTVAMPFSPVERS"
     gene            8053..9108
                     /locus_tag="BMZ54_RS20940"
                     /old_locus_tag="SAMN04488505_105296"
     CDS             8053..9108
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015552.5"
                     /locus_tag="BMZ54_RS20940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN04488505_105296"
                     /product="tellurite resistance/C4-dicarboxylate transporter
                     family protein"
                     /protein_id="WP_089916809.1"
                     /transl_table=11
                     /translation="MPQTQLAHPGQPVMATSLENFFPGYFALVMATGIVSIGMFLWKYA
                     WLAGIFLGLNVFFYLLLWIILILRIVKYPLVVWNDLHHSARGVTFLTLVAGNNVLGSQI
                     AIITGRMDIALVLWIAGFILWALILYTFFLVNILKEPKPALQQSISGAWLLIVVATESV
                     AVLGAIIANSSSYHWLIAFISLCSYMTGGMFYFVLIGLILYRWLFFSMKAETLTPPYWI
                     NMGAVAIITLAGSRLVAYARVHEELKEWAGFIQSFTMFFWAFASWWIPLLFLMFAYRHF
                     IARVPLKYDPQYWSMVFPLGMYGVCTYTYAGITGFTFIKPISALFVILALLTWVIVLIG
                     LFIDLASARKR"
     gene            9148..10212
                     /locus_tag="BMZ54_RS20945"
                     /old_locus_tag="SAMN04488505_105297"
     CDS             9148..10212
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BMZ54_RS20945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN04488505_105297"
                     /product="MFS transporter"
                     /protein_id="WP_089916813.1"
                     /transl_table=11
                     /translation="MYFSLNKKAAFIAIVVTLFCVIVSFYGSRKLQNFDPALIAYLFGT
                     LFAVFGVIYRYCVWLQRPPTRMYFRRTWQLIFTGRFFVHAYTLLIDSIKNLLFQHFIYP
                     RGKKRWLAHFMLATGCLAAFAITIPLTLGWINFTLDPATALDPGAIKLYNANFFGFKVM
                     SFELGSVLAFLIFHALTWCSWLVIAGAVIFLVRRLTNAGLIASQTFEGDLLPLILLIFI
                     AVTGLGLNFSYAFMKGIAYDFMSVTHAISVILFLVWIPFGKFFHIIQRPAQIGAHIYKQ
                     EGKKKGMAVCPHTGKEFTTQLHVDDLKIVTKQLGFDFTLEDGTSHLDYSPEGKRSLLAK
                     AHLKARQEGGTFFG"
ORIGIN
        1 taacttttta tcaggcttca ccgttcgtgt cacgccggcc aaggtccgta gtttggaact
       61 atggaccttg gtattaccgc gtggaaatgt gatacctcag ttgctcactt gcggtactat
      121 tgtaacactg gtatttcgct ggcaggtccg ggcagaggcc cttggccggt gtgatgcgct
      181 tgatgaagcc caatagcgca agtgtgctaa tacgatacca cctcgttcaa tagagaacta
      241 aacaggcggg caccaggccg tagccggacc tgtaagaaat gtcctcatgt aatattaaga
      301 atacactttt atcgaagtac tatagtaacg ctggtatttc gctggcaggt ccgggcggag
      361 gcccttggcc ggcgtgatgc gcttgatgaa gcccaatagc acactcatgc tgatacgata
      421 atccctcgtt taatagagaa tcaaacaggc gggcaccagg ccgtagccgg acctgcaaga
      481 aatgtcctca tgtatgttta tattaaccag gattaaaaca aacagcaaac ggtttaccgg
      541 gaaatgttag ctaacaatat tactccacaa agcgatagct gccatgagta tcatagtcga
      601 tattatgctt cttttttagc gcttgtatat agtttaaggt accaactgta tgaggacttg
      661 caacggaatc accaacccgt tcaaaggtgt gcagcagtgt ttcttccagg cagctgctta
      721 cggtcatgcg cttatgctcg gcaaggtctt gcaataacgc agccaaccgc ttttcaagcc
      781 gtacaggtac atctacccgc tcaattttaa tgggaggccc ctggttatag atgtatctgc
      841 caaaaaccag ggaattgccg tcagcatctt ttacccgata atcgcgtatt ccatattctc
      901 tgtcttccat cggaactatt atctccacgc cattagcctg gtgcaattca tagagctctt
      961 cagcattttc tgtaatgaaa catacttcag atgctccatc cacaaaggac tcaccttttt
     1021 gcagatgcaa attcacctga cccagcccta caccggcaaa cgtgggagga tcaccccagg
     1081 agaagcgatg tgaaaacccc aggcggttaa cataaaaatc aatcgcagac ggtatatctt
     1141 taactaatag ggtaggaaaa agctgggagc attcaatatt tgggatcatg gcaattacta
     1201 ttttaaagta agagaaataa tatttgcatt aagttatgaa tagtgagagt agtttccaac
     1261 ttccggggag agctacaccc cgggtgataa acgtggaaaa cagtataaag actataatgt
     1321 aaacagttta aagcctataa ttgatcttgc cttattgcag tactaatata aagctggtat
     1381 ttcgctggca ggtccgggcg gaggcccttg gccggcgtga tacgcttgat gaagcccaac
     1441 ggcacaaata tgctgatacg atactacccc cgttcaatag aggtctaaac aggcgggcac
     1501 taggccgtag ccggacctgc aagaaatatc ccccatacaa tgtaagaaac caccttgaca
     1561 caattaatct acgccggccc cgtataatgc agcttcacca gctgcgcaac cgcgtcccgc
     1621 gatgctgccg catcaggctc tttatcttct attttctcca cctgctctgc aagcgtttca
     1681 tcatttacac tgttccgcat ccaggcagag taatcgtgcc gttgcaaatg atacagccag
     1741 gtatcatcat ccacgccttc tgcaatttct acaaagcgca gcaggttgct ggctttgagc
     1801 tgcagctttg cttccggtcc ggtgaagatg aagctgtccg gtcccatatc gccaatagcg
     1861 tatttacgtt tatgccgctg cagtattttt tgaggaacta aggtgcgtat caggaaaggc
     1921 gcttcgccgg aggggcggtg ccataccagg gcttcgccct tttgcaggtc tgcaataggt
     1981 atttccggga gggcggcttt aatgcagctc gcgtaatgat gaatggtctc atgcggtgct
     2041 tgccctaccg ccattatggt ggtagcctgg tccagtagtg actgatgtaa cagctccgga
     2101 cgggtagtaa tagcaatata attagtgaag gcatgtagtg gagtaaagaa gtgcggatta
     2161 gcttcagcag gcgccaggtg gtgcgcttca tccagtagta tccagtgtgg gcggcctttg
     2221 tgctggcgta gctctaaaac ggcagccagc agctgttgca ggaaagcggg cttttcttcc
     2281 atagataaag ccagtgtgca tactatcacg ctttgatgcg gcctatccag cagctgcatc
     2341 agcggttcca gggcaggcgg ctgcgctaca tcgccgatgg ttaccgttcc ctgcagctcc
     2401 aggtaatcgc cttccgggtc tatcatgatg aactggtagc cgcgttgtag caatatctcc
     2461 ataaaggcgg cggtgaatgt ggtttttcca cccccgctgc taccggcaag aataatgttg
     2521 ctgccatagg ggctcaccag gaagggggca ttatcatagc ggtcgccaag cggcaggtag
     2581 tgtcttttca gtacagagtc cagcgtcagc aggtcgtctt cacgcatgcg ggcagccagc
     2641 tgcattaccc cttcaccatg atcggccggt gttacccagt cgctgatctt ttgcagggta
     2701 ggcagcgcgt tggccacact tactgcgcat tcagctacct gcagcatagc gctgtcattt
     2761 tctgcatcac ctacggccac tacattatgc atggaaaatc ccatggcatc taaagctgca
     2821 ttgaggcctt tggatttgtt gatgcccggt ggtaatacca ttacggcgcc tttgttaaag
     2881 atgatctgcc gttctatgcc aaattgtttg atcacttcca gcacagtatc ctggtgcggt
     2941 tcccaggtag caactataac gcggcctgcg gaaaggggct gcacgccgcg cttacgcagc
     3001 tcggcaacaa aagcttcggg aggtgcatcg cccagggtgg tttcttccaa tgtagcggga
     3061 ttatatatta aggcgccatt ttctgctact atacggtcaa ataccgtatg tgccgggaat
     3121 agcgctttca gctcatccag ctcgcggccg gttaccagca gcaggctgcg gccactggcc
     3181 ttcagcgctt tcaatgcttc tactacttca tcggtaacgc cgccgtggtg agccagcgta
     3241 ccatcataat cggatgccag aacatagtat ctcataacag tttaagagca gtaattatgc
     3301 cactggataa gctaaatgtg gggagtaaag gggcagttct taaatatttg caaaaaacag
     3361 cataaattgg atgaccggct cattggaatg tgatgaatat ccctattttt gtttacctac
     3421 actttgttta tgagcgcagc taaaggagca gtaactggtc atcatgctat catccgcgaa
     3481 tgggtgcagc tgtacacaaa cggaatgtac gcctgggcct atcataaaac taccgacaag
     3541 gcgctggcag aagatctggt acaggacacg ttcctcgccg cgttacagtc attcgataag
     3601 tttaaacagg aaagtcagcc taaaacctgg ctcttttcta tcctgaataa taagatcagc
     3661 gatcatttcc gtcaacaatt ccgccatccg gttgttaacg aagcagaggg cggcttatct
     3721 tttttctttg atgaggagga tgagtggcgc aaagaacgca gtccgcaagc ctggaatact
     3781 acggatacac atatcctgga caacccggat ttccggaaaa ttctgcagca ctgtatgcat
     3841 ctgctgcccg gcaactggct ggcagcagta aaattaaaat acctggaaga aaaagaaggg
     3901 aaggatattt gtcaggatct tcagataaca ccgtctaatt tctggcagat catgcaccgc
     3961 gctaagctgc atctgaggaa ttgtctggaa attaactggt ttaaaaagta gatcgggcat
     4021 gaaaagagtg ttaaaaaaaa tatttcttcc ctgtacggta gctacggaaa tgattgagaa
     4081 ggacatttac tttaaactgt ccgcgttaga gaaattacgg ctgttcctgc ataccggtct
     4141 ctgtggcctg tgtcaccggt atcaaaaaca tagccggctg ttgcatcgga tcctgatgga
     4201 gctgcatcat gagcatgaac atcctcaagc acccaaagaa gaggagcaga ctgcactgaa
     4261 agaaaagatc acaaaccgcc tggaaaagaa ttaaaaattt gttggttacg gtgtcaggtt
     4321 ggtataaatg tgccggctat acgtgcaaag attctaatca catataaaaa ctgacaacaa
     4381 tggagaacaa aaagaaagtt ctgttaaccg gctctctgct ggccggcgcc ttattggcta
     4441 ctgcaaacct gcaggcaaat gctgcagacc tgtttagttt caacaacctg ggtaccggcg
     4501 aagccgtaag aacccgcctg atggacggcg ccagccatgc ccgtaccctg gagctgaact
     4561 gtggcgaaaa gaaagattcc gcttccatga aaaaaggtaa agacggaaaa tgtggaaaag
     4621 atggtaagtg cggcgaaggc aagtgcggcg ataaaaaagg tggtaagaaa aagatgaagg
     4681 ccgactccgc caaagcaaaa ccggctaaat agttggcagt ccgcagttgg cagtgtgcaa
     4741 tccttgtaaa tagttggcag ttggcagtga gcagttggca gtctgcgaag attgtttact
     4801 gctacctgtc ccctgccaat tctaaaaggt agtttgtatc agcagcaacg cagcaatctc
     4861 ccttactgcc aactgcctgc taacgactgt caactcttaa aagtcggttc gtaagagcac
     4921 cacgcagtag tcgccactac tgccaactgc ccactgcaga ctgcccactc aaaaaatctt
     4981 cacgctcaaa ttgcctcctc atggttggaa ttggttttag aaaagatttt gcaaccacac
     5041 tgttgcaaag cccttcattc aacccggcct tcattgaagt agcgccggaa aactggatag
     5101 gggtgggcgg ttactggaaa aaactgttta accaggcgct ggaaaaatat ccgctgtata
     5161 cacacggcct ttcactttct gtaggcagcc ccgacgagct ggacctgaac ttcctgcaaa
     5221 aagtaaaaac cttcctgcgg gataccaatg cgcagatcta ttccgaacac ctcagctact
     5281 ctaaatgtga taacgcgcat ttatatgacc tgctgcctat tccgttcaca acggaagcgg
     5341 tgcgtcatgt aagccgccgt atccggcagg tgcaggattt cctggaaagg aagatcgcca
     5401 ttgagatcgt aagctattac acaccggtag cacctgagct tacagagatc gctttcatta
     5461 atgccatact ggaagaagca ggttgtaacc tgttgctgga tgtgaacaat gtgtatgtga
     5521 acggctttaa ccatcagtac gatgccaaag cattcataga ccagctgccc atggataaag
     5581 tagcttacat ccatatggcc ggccatgaaa aagtatcgga tgacctgatc attgataccc
     5641 acggagaagc tatcatagac ccggtgtatg acctgtttgc ctataccatg cagcgcctgg
     5701 accgtgatgt accggtgctg ctggaaaggg attttaacat ccctgagctg gatgagctgc
     5761 agcaggagat caaccgcctg cagcagatca aaaatgtgca cctgaaaaac ccgcgttatg
     5821 caactgcctg aaactaccca ccagcaccag tcggccctgg cagattattg ccgcaccggt
     5881 aagtacagcg ctattcccgg tgtgcgggaa cagcatgtaa cgcagtaccg ccgcctggta
     5941 tacaatgtgg tggatgatat gttgcaatca gcctatccgc tcacacatca tttgcttaca
     6001 acaagagagt ggaatgcgct ggtgcaggaa tttttttcca atcatccctg ccagtcgccg
     6061 caggtatggt acatgcccaa agagctctac gaatatctat cgcccaaaga acataagctt
     6121 aaaaacaagt acccgttcct gttagagctg ctttggctgg aatggctgga agtggagctg
     6181 tttatgatgg aagaccggcc ggccgcttac accaccatag gcgatctttc aacagatgaa
     6241 ttagtcctga atcccgaaca tcatttacag caattccaat accccgttca cctgaaaacg
     6301 gctaaacagc tcacgcctgc tgataaaggc gattatttcc tggtattatt ccgcaagccc
     6361 gacagcgggg aggtgaattt catgaatctt tcgcccgcgc tggtagccat gctggaaata
     6421 ttacaggaag gcccgcaaac aatggatgcc ctgatccggc aatgctgcgc cgcctggcag
     6481 ctgcagctta gcccggaaat acaggctgcg gcgcatgctt tcatcacaca atcgctggac
     6541 aaccggctga tcatcggatt taaaagcaaa cactaatgag catcttatca tcctacgccc
     6601 gcacggcggc atccctggag aaagccaggg cagtaccctt attgttatta cggcttgtac
     6661 tggcctatgg tttttacaca cccgccaaaa tgaaatggtc cgatattaac agtattgcac
     6721 agtggtttgg cagcatgcac tttcccatgc ccacgctgag cgcttacctg gctgctgcta
     6781 cggaagccgc aggggtggta ttgcttaccc tgggcctggc cacccgcctt attaccatcc
     6841 cattaatgat cgtagtgctg gtagctattt ttgcagtgca ctggcccaat ggtttcagcg
     6901 cgggcgataa tggttttgag atcccgctgt attatttcct gatgctgttt acattattta
     6961 ttatgggacc aggcagtata agtatggatg aacggctgcg tagaaaatat agaaactaac
     7021 ccttagtttt gctatacaaa tttcctgtat ggcactccgc atcaacccat tttccaaaat
     7081 aaacaacgat accggttttg gcagcagctc cagcggttct gtagggcgtt ttgtgaacaa
     7141 ggatggttcc tttaacctgc gcaaagaagg ccgcccgtac tgggagcgca tgagccttta
     7201 tcacttcatg ctgaacctgt cgccgctaaa attcttttgt gccatcctgc tgttcttttt
     7261 ttccattaac cttatctaca ccgctattta cctggtattg ggcgcgcatg aatttgtagg
     7321 tattataggc caaactaagt ggcaggtgtt caaagagatc tatttcttca gcacagaaac
     7381 ctttactacg gtaggttatg gccgggtaaa ccctattggc gacggcgcca acctggtagc
     7441 ctccctggaa gccctgaacg gtttcctgta cctggcagta ttcaccggtt tgatctacgg
     7501 gcgtttttcc aagcccaaag ctttcctcat gttcagtgat tacgcaataa tagcgcccta
     7561 ccaggataaa atggggctta tgttccgttt tgcatcctat aagaacaatc atacgcttac
     7621 agatgtagag gtaaaggtaa ccgcggcatt actggtaact gaaaatggta aaaccgcttt
     7681 ccagttctat gacctgcccc tggaacgcag caagatccag aacctgccca tgaactggac
     7741 cgtagtgcat cctatagatg agaacagccc tttacaggga ctaaacccgg aagatctgaa
     7801 ggccgctgac ctggaaattt atgtgctcat ccgtgccttt gatgatgtgt tctccaattt
     7861 tgtattaagg cgcacctctt atacatacga agaaattaag ttcaaccgcc gctttgtgcc
     7921 tatgtaccgg gaaactggta ccagcactat cctggagctg cataagctca gtgactccaa
     7981 agaggtggat gttacggtag caatgccgtt cagccccgtt gaacggtctt aatacattct
     8041 aaaaccctca acatgccgca aacccagctc gcacaccccg gtcagccggt tatggccact
     8101 tccctggaaa atttctttcc tggttatttt gcactggtaa tggctactgg tatcgtatcc
     8161 attggtatgt tcctgtggaa gtatgcctgg ttagccggca ttttcctggg cctgaatgta
     8221 tttttttatc ttttgctctg gatcattctt atcctccgga ttgtgaagta tccgctggtt
     8281 gtatggaatg atcttcacca ttccgccagg ggcgtaacat tcctgacgct ggttgccggt
     8341 aataatgtgc tgggaagcca gatagccatt attaccggcc gcatggatat agcgctggta
     8401 ttatggatag cgggatttat actctgggcg ctgatcctct acactttttt cctggtcaat
     8461 atcctcaaag agcccaagcc tgcgctgcag caaagcatta gcggcgcctg gctgctgata
     8521 gtggttgcca cagaatcggt agctgtttta ggcgccatta ttgccaacag cagctcctat
     8581 cattggctga tcgcatttat ttcgctgtgt tcgtatatga caggcggcat gttctacttt
     8641 gtgcttatcg gtctgatcct ttaccgctgg ctttttttca gcatgaaagc agaaacgctt
     8701 acgcctccat actggatcaa catgggagcc gtagccatca ttacgcttgc cggttcccgc
     8761 ctggtagcgt atgcccgtgt acatgaggaa ttaaaagagt gggcgggttt catacagtcg
     8821 tttacgatgt tcttctgggc tttcgccagc tggtggatcc ccttactttt cctgatgttt
     8881 gcctaccgcc attttatagc ccgggtaccc ttaaagtatg atccccagta ctggtctatg
     8941 gtgtttccgc ttggcatgta cggcgtatgt acttacacct atgcaggtat aacagggttt
     9001 actttcatta aacctatttc ggcattattt gttatattag ctttactgac ctgggtcatt
     9061 gttttgatcg gtttgtttat tgaccttgca tcagcgagga aaagatagtg tcattgtttt
     9121 cttccggata accataaaaa ggtgcttatg tatttttctc tcaataaaaa agccgccttt
     9181 attgcaattg ttgttactct tttttgcgta atagtttcat tttacgggtc caggaaactg
     9241 cagaattttg acccggcatt aattgcttat ttatttggta ccctctttgc cgtgttcggc
     9301 gttatttacc gttattgtgt atggctgcaa agaccgccta cccgcatgta tttcaggcgt
     9361 acctggcagc tgatctttac cggcagattt ttcgtgcacg cctacacgct gttaatagat
     9421 tccatcaaaa acctcctgtt ccagcacttc atttatccca ggggcaaaaa acggtggctg
     9481 gcccatttta tgctggctac aggctgcctg gcggcttttg ccatcaccat tccgcttacg
     9541 ctgggctgga tcaactttac gctggacccc gccaccgcgc tggaccctgg cgccattaaa
     9601 ttatataacg ctaatttttt cggctttaaa gtgatgagct ttgagctggg atctgtactg
     9661 gcatttttaa ttttccatgc cctcacctgg tgctcatggc tggtaattgc cggcgcggtt
     9721 atatttcttg taagaaggct caccaatgcg ggcctcatcg cttcccaaac ttttgaagga
     9781 gacctgctgc cgctcatcct gctcatcttt atagccgtta caggattagg gctcaatttc
     9841 agctatgcat ttatgaaagg cattgcgtac gattttatgt cggtaaccca tgctatttcc
     9901 gttattcttt tcctggtatg gatccccttc ggcaagttct tccacattat acagcggcct
     9961 gcacaaatag gcgcgcatat ttataaacag gaaggaaaga aaaaaggcat ggccgtgtgc
    10021 ccgcataccg gcaaagaatt taccacgcag ctgcatgtag atgatctgaa gatagtgact
    10081 aagcagctgg ggtttgattt taccctggaa gatggcacct cgcatctcga ctacagccct
    10141 gaaggcaaac gctcactcct ggcaaaggcg cacctgaaag cccggcagga gggaggcacc
    10201 ttttttggat aaccatcccg gcatcaccgg gaaaataata cgaccagcat ggcaaaacta
    10261 cccgtatccc ccgaaaaact tattacccgt tttggtcctc acctcaactt tgccccgcag
    10321 gaaggttatc ccggaaggga tgagccggat gccacggtga aaacgcattg ctgcttttgc
    10381 ggcatgcaat gcggtataca gctgctggtt aaaaataata aggtggtagg ctttgagcca
    10441 tggatggagt tcccctttaa ccagggacgc ttatgcccca aaggcgtgca acgttacctg
    10501 caggataatc atcccgaccg cttgctggag ccggtggaaa gagtggaagg cgaaggcttt
    10561 aaacctgttt cctgggatca tgcgcttaac agggtaacca cagaaattaa acgcatacag
    10621 gccgccaacg gcaaagatgc atttgctgtg ctatccggcg tttcactcac taacgaaaaa
    10681 agctacctca tgggcaaatt tgcccgcgta gcaataaaaa cagctaacct ggattacaat
    10741 ggccggctat gtatggtaag cgccggcgcc ggtaataaaa aggcattcgg gctggatcgt
    10801 tcttccaata actacgaaga tcttgaacat g
//
