LOCUS       NZ_FNNQ01000008        19193 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Marininema mesophilum strain DSM 45610, whole genome shotgun
            sequence.
ACCESSION   NZ_FNNQ01000008
VERSION     NZ_FNNQ01000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Marininema mesophilum
  ORGANISM  Marininema mesophilum
            Bacteria; Bacillota; Bacilli; Bacillales; Thermoactinomycetaceae;
            Marininema.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-OCT-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_900106775.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 01:02:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,196
            CDSs (total)                      :: 3,130
            Genes (coding)                    :: 3,066
            CDSs (with protein)               :: 3,066
            Genes (RNA)                       :: 66
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 1 (5S, 16S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 21 of 64
            Pseudo Genes (incomplete)         :: 50 of 64
            Pseudo Genes (internal stop)      :: 5 of 64
            Pseudo Genes (multiple problems)  :: 11 of 64
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:56:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 19193
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            FNNQ01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..19193
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..19193
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..19193
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[4145:9193](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4146..9193)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(<1..182)
                     /locus_tag="BLV90_RS08870"
                     /old_locus_tag="SAMN05444487_1081"
     CDS             complement(<1..182)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002194848.1"
                     /locus_tag="BLV90_RS08870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_1081"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_177167880.1"
                     /transl_table=11
                     /translation="MHKAFKFRLCPTKEQTNLINKSIGCSRFTFNHFLARWNESYDSTG
                     KGLTYGTCSAQLTSL"
     gene            complement(320..676)
                     /locus_tag="BLV90_RS08875"
                     /old_locus_tag="SAMN05444487_1082"
     CDS             complement(320..676)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLV90_RS08875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05444487_1082"
                     /product="Hsp20/alpha crystallin family protein"
                     /protein_id="WP_091739489.1"
                     /transl_table=11
                     /translation="MLRPWLAKGPEDWVGEIFLQMQRLSQELEQNRIHGDFYQKDGMLI
                     VMIEIPGLRERHEIDVRVEGQILIVRGTTGSTDSVEESAFVYEMLLPGKVEVSRMETHA
                     DPTDRMLTIRLPLM"
     gene            complement(736..891)
                     /locus_tag="BLV90_RS16230"
                     /old_locus_tag="SAMN05444487_1083"
     CDS             complement(736..891)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007202139.1"
                     /locus_tag="BLV90_RS16230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_1083"
                     /product="hypothetical protein"
                     /protein_id="WP_177167969.1"
                     /transl_table=11
                     /translation="MTKAHTKGGGNFGGFGGGWFSGIWIALAVIFILFIFFAIFWWWSS
                     CGGPYY"
     gene            complement(1039..1587)
                     /locus_tag="BLV90_RS08880"
                     /old_locus_tag="SAMN05444487_1084"
     CDS             complement(1039..1587)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004436309.1"
                     /locus_tag="BLV90_RS08880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_1084"
                     /product="DJ-1/PfpI family protein"
                     /protein_id="WP_218142293.1"
                     /transl_table=11
                     /translation="MMAKVLILTGDAVEALEVFYPYYRLLEEGHEAVIAAPTKKRLQTV
                     VHDFEPHIDTFTEKHAYGLDSHISFDEINPTDYDGLIIPGGRAPEHIRMHGKLPDIVRH
                     FFTTNKPVGAICHATLVFNVVPDVLKGRSLTAFSNCRPEVEATGARYIEEPLHTDGNLV
                     SGHAWPDLPGFMKEFLRLL"
     gene            1830..3065
                     /locus_tag="BLV90_RS08885"
                     /old_locus_tag="SAMN05444487_1085"
     CDS             1830..3065
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="BLV90_RS08885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_1085"
                     /product="MFS transporter"
                     /protein_id="WP_177167970.1"
                     /transl_table=11
                     /translation="MNRFPLSFRALWLGQGVANLADSFYIIAIVTLLYNLSGSATMAAS
                     IPLLRVGAQMTSGFIAPLLLHRFPLHRILLTSQTGQTFLLIILATMISWLKSPLPGLAL
                     VFGTSFLDGWTTPARNALVPRLLPTDSLIRGNSWLATTDQTIMLLGWSTGGLLVAYLGS
                     SSLLWISVGLFIISCLALTPVRDPEPKNDGPEKRPPRWHIMKEGWSTILNNPTLRRITL
                     MDVIETASGTIWIGAIILVFVKEILHRGETWWGWINASYYTGTVLGGLLILTLSRLFAH
                     RLVLGMIIGSVCNSVLTLLFALLPVPIVSLVLSILMGPCYQLRDITQRTLFQQALSSET
                     TPKVFAAHGTLMYGVFGLAVFVTGVVADSFGVRSVYLATAGLLACSVMIGTPLLRSNNR
                     SSSESTCHSSRG"
     gene            complement(3126..4073)
                     /gene="corA"
                     /locus_tag="BLV90_RS08890"
                     /old_locus_tag="SAMN05444487_1086"
     CDS             complement(3126..4073)
                     /GO_function="GO:0015087 - cobalt ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0015095 - magnesium ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006824 - cobalt ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0015693 - magnesium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="corA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014417210.1"
                     /locus_tag="BLV90_RS08890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_1086"
                     /product="magnesium/cobalt transporter CorA"
                     /protein_id="WP_091739497.1"
                     /transl_table=11
                     /translation="MIHTLAVTCDEEALLDLELAQLKEDRIKWYWVDFATPTEEEANLL
                     ADFFEFHPLAIEDCLHRLQRPKMDYYNDHVFLIVHDMNTDTLKPKEVNLFVGENFIVSF
                     HLHRSDEIEETRRRVFKAQDLSNHGPTVITHMIMDKIVDTLFPVVHKIEDRLDELDSRQ
                     EASTPKLIDEVFTIRSDLIRLRHSVMPMRDLLYRIINSKQFMRTEERRFYFSDIHDHLV
                     KLAHMIESNREMTADIRDSYLSLNSFRMNRIMKTLTIITVIFMPLTFLAGVYGMNFTNM
                     PELHTKEGYFIVLGVMILIALSLTMWFKSKGWFD"
     misc_feature    complement(4133..4148)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.85"
                     /tool="antismash"
     gene            complement(4146..5762)
                     /locus_tag="BLV90_RS08895"
                     /old_locus_tag="SAMN05444487_1087"
     CDS             complement(4146..5762)
                     /NRPS_PKS="Domain: AMP-binding (14-436). E-value: 4.3e-88.
                     Score: 287.6. Matches aSDomain:
                     nrpspksdomains_BLV90_RS08895_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010283540.1"
                     /locus_tag="BLV90_RS08895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_1087"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_091739499.1"
                     /sec_met_domain="AMP-binding (E-value: 3.3e-106, bitscore:
                     348.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNVPLLISPMLERAERVFPKKEIVSCTPSGLHRETYAEMGVRAR
                     RLSNALQKLGINNGDRVGTLAWNHYRHLEAYFAIPSMGAVLHTINLRLSPEHLAYVINH
                     AEDRILLIDDNLLPLIEAIRDELTTVEAFIIMTDQSELPETNLSPLYSYEELLSQGNPE
                     FVYPKDLDENSPAGMCYTSATTGMPKGVLYTQRSIYLHSMISGLADTVGLSEGDTCLSV
                     VPMFHVNAWGLPFAATWFGAKQVMPGPMMKADVIANLIQSEKVTVTGGVPTIWMSLLKE
                     LETKSYDLSSLRMLLFGGASAPPSMIRAFEEKHGIPVVHAYGMTETSPIVTVSHLKSYQ
                     KDLPLEERLAIKAKQGVVSPGLEVRALGPDGKEIAWDGEEMGELLIRGPWIADGYYKGD
                     RSTDSFREGWFHTGDVVTIDTEGTIKIADRTKDLIKSGGEWISSVDLENAIMAHEGVYE
                     AAVVAMPHEKWQERPVACVVLKEGYREEITAEVILEFLRPSVAKWWLPDEVIFMDELPK
                     SSVGKFLKRALREQLKSRLSM"
     aSDomain        complement(4455..5720)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BLV90_RS08895_AMP-binding.1"
                     /evalue="4.30E-88"
                     /label="BLV90_RS08895_AMP-binding.1"
                     /locus_tag="BLV90_RS08895"
                     /protein_end="436"
                     /protein_start="14"
                     /score="287.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AERVFPKKEIVSCTPSGLHRETYAEMGVRARRLSNALQKLGINNG
                     DRVGTLAWNHYRHLEAYFAIPSMGAVLHTINLRLSPEHLAYVINHAEDRILLIDDNLLP
                     LIEAIRDELTTVEAFIIMTDQSELPETNLSPLYSYEELLSQGNPEFVYPKDLDENSPAG
                     MCYTSATTGMPKGVLYTQRSIYLHSMISGLADTVGLSEGDTCLSVVPMFHVNAWGLPFA
                     ATWFGAKQVMPGPMMKADVIANLIQSEKVTVTGGVPTIWMSLLKELETKSYDLSSLRML
                     LFGGASAPPSMIRAFEEKHGIPVVHAYGMTETSPIVTVSHLKSYQKDLPLEERLAIKAK
                     QGVVSPGLEVRALGPDGKEIAWDGEEMGELLIRGPWIADGYYKGDRSTDSFREGWFHTG
                     DVVTIDTEGTIKIADRTKDLIKS"
     CDS_motif       complement(4563..4622)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLV90_RS08895_0003"
                     /evalue="1.70E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="BLV90_RS08895"
                     /protein_end="400"
                     /protein_start="380"
                     /score="14.0"
                     /tool="antismash"
                     /translation="MGELLIRGPWIADGYYKGDR"
     CDS_motif       complement(4758..4805)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLV90_RS08895_0002"
                     /evalue="9.90E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="BLV90_RS08895"
                     /protein_end="335"
                     /protein_start="319"
                     /score="-3.0"
                     /tool="antismash"
                     /translation="HAYGMTETSPIVTVSH"
     CDS_motif       complement(5181..5231)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BLV90_RS08895_0001"
                     /evalue="1.30E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="BLV90_RS08895"
                     /protein_end="194"
                     /protein_start="177"
                     /score="14.8"
                     /tool="antismash"
                     /translation="MCYTSATTGMPKGVLYT"
     gene            complement(5929..6297)
                     /locus_tag="BLV90_RS08900"
                     /old_locus_tag="SAMN05444487_1088"
     CDS             complement(5929..6297)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BLV90_RS08900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SAMN05444487_1088"
                     /product="hypothetical protein"
                     /protein_id="WP_091739502.1"
                     /transl_table=11
                     /translation="MAINEGWLAHLHALNALEELYHEYWDLDLAEKVRQELASSVDLLG
                     SHVEKVPCPCGDTSEDVTFYRSLLGHAEAAVVERNLFPLPLVQEALAHHFSTMSENHRC
                     IRRLLGWEHDWVKGMEKG"
     gene            complement(6462..7601)
                     /gene="leuB"
                     /locus_tag="BLV90_RS08905"
                     /old_locus_tag="SAMN05444487_1089"
     CDS             complement(6462..7601)
                     /EC_number="1.1.1.85"
                     /GO_function="GO:0003862 - 3-isopropylmalate dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="leuB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712072.1"
                     /locus_tag="BLV90_RS08905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_1089"
                     /product="3-isopropylmalate dehydrogenase"
                     /protein_id="WP_091739505.1"
                     /transl_table=11
                     /translation="MAAPKRIAFLPGDGIGPEITDEGAKVMKATGERFGYTFQIDFGWI
                     GGSAIDRLKNPLPEETLTLCKQADAVLLGAVGGPSWDRNPPELRPEKALLGLRKELDLF
                     ANLRPTTLFPGLEESSTLKAEVLQGVDFLVVRELTGGIYFGEKFTEETPAGERATDTLV
                     YTEVEVERIVRRAFEIAQVRRGKVTSVDKANVLESSRLWRKVAERVAKEYPDVELDHLL
                     VDNCAMQMIRRPADFDVIVTENMFGDILSDEAAILTGSIGLLPSASLGEGHRGLYEPVH
                     GSAPDIAGQGVANPIATILSVALMFRYSFHDDAAAKAIEGAVNDVIASGARTMDMASTE
                     SLALSTEEVGDKVVEALKKYQPDPTIPVEAMMSNDSIKM"
     gene            complement(7625..9193)
                     /locus_tag="BLV90_RS08910"
                     /old_locus_tag="SAMN05444487_10810"
     CDS             complement(7625..9193)
                     /EC_number="2.3.3.13"
                     /GO_function="GO:0003852 - 2-isopropylmalate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF002086.0"
                     /locus_tag="BLV90_RS08910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_10810"
                     /product="2-isopropylmalate synthase"
                     /protein_id="WP_091739508.1"
                     /sec_met_domain="HMGL-like (E-value: 7.7e-101, bitscore:
                     330.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRNVQFFDTTLRDGEQSPGVNLNVEEKVAIALQLEKLGIHVIEA
                     GFAASSPGDREAVRKVGEAVQNPTVVSLARAVRSDIDAAWEALKTAVNPGVHVFIATSP
                     IHREYKLNMTKEEVLNQAEDAVRYAKLFFSHVEFSAEDGGRTELDFLCEVVKRAIDAGA
                     DVINIPDTVGYLSPQEYGNIFRYIKTHVPGIEKVKLSAHCHDDLGMATANSLAAIEAGA
                     EQVEGTINGIGERAGNVALEEVAMALYTRASYYGMETDLQLSEIARTSRLISKMTGMFV
                     PGNKAVVGTNAFAHESGIHQDGMLKNAATYEIMNPETVGQSNTLLVLGKHSGRHAFRDK
                     LSQFGYAFNDEQINQLFHRFKELTDRKKVIEDEDLVSLIEERIGEEEEEVFTFETVQVA
                     YGSQSVPTASLRLMDNRMGLKVEEAACGNGSVDAIFKAVDRITNESWNLADYKIVSVTH
                     GTDSLGEVYVKLHDDDSDITVQGRGVSTDILEASARAYIHGINRLLSMRNRQKKQKEIA
                     PAVGE"
     gene            complement(9218..10225)
                     /gene="ilvC"
                     /locus_tag="BLV90_RS08915"
                     /old_locus_tag="SAMN05444487_10811"
     CDS             complement(9218..10225)
                     /EC_number="1.1.1.86"
                     /codon_start=1
                     /gene="ilvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712070.1"
                     /locus_tag="BLV90_RS08915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_10811"
                     /product="ketol-acid reductoisomerase"
                     /protein_id="WP_091739511.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2e-11, bitscore:
                     36.6, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKVYYAKDADSKNLAGKTVAIIGYGSQGHAQAQNLRDSGVQVVV
                     GLRKGKSWEKAEKDGFTVLEVAEAVKQADLINLLMPDEIMPRVYKEEVEPHLKPGSALF
                     FSHGFNIHFEQIQPPSNVDVALIAPKGPGHLVRRVYAEGFGVPALIAVQQDASGSATEI
                     GLAYAEGIGATRAGVIETTFKEETETDLFGEQAVLAGGVSSLVKNGYETLIEAGYQPEI
                     AYFECFHELKLIVDLMYEEGLAGMRYSISNTAEYGDYVSGKRVVGDASRTAMKEVLQEI
                     QDGSFAKKWIAENESGGHEFLRMREEESQHSLETTGAKLRETMAWINQKNSVKA"
     gene            complement(10414..11421)
                     /gene="ilvC"
                     /locus_tag="BLV90_RS08920"
                     /old_locus_tag="SAMN05444487_10812"
     CDS             complement(10414..11421)
                     /EC_number="1.1.1.86"
                     /codon_start=1
                     /gene="ilvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009712070.1"
                     /locus_tag="BLV90_RS08920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_10812"
                     /product="ketol-acid reductoisomerase"
                     /protein_id="WP_091739514.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2e-11, bitscore:
                     36.6, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKVYYAKDADSKNLAGKTVAIIGYGSQGHAQAQNLRDSGVQVVV
                     GLRKGKSWEKAEKDGFTVLEVAEAVKQADLINLLMPDEIMPRVYKEEVEPHLKPGSALF
                     FSHGFNIHFEQIQPPSNVDVALIAPKGPGHLVRRVYAEGFGVPALIAVQQDASGSATEV
                     GLAYAEGIGATRAGVIETTFKEETETDLFGEQAVLCGGVSSLVKNSYETLIEAGYQPEI
                     AYFECFHELKLIVDLMYEEGLAGMRYSISNTAEYGDYVSGKRVVGDASRTAMKEVLQEI
                     QDGSFAKKWIAENESGGHEFLRMREEESQHSLETTGAKLRETMAWINQKKSVKA"
     gene            complement(11449..11940)
                     /gene="ilvN"
                     /locus_tag="BLV90_RS08925"
                     /old_locus_tag="SAMN05444487_10813"
     CDS             complement(11449..11940)
                     /EC_number="2.2.1.6"
                     /GO_function="GO:1990610 - acetolactate synthase regulator
                     activity [Evidence IEA]"
                     /GO_process="GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="ilvN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018756261.1"
                     /locus_tag="BLV90_RS08925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_10813"
                     /product="acetolactate synthase small subunit"
                     /protein_id="WP_091739517.1"
                     /transl_table=11
                     /translation="MRHVLSVLVNDQPRVLARVTTLLGPRNFNIESISVGESEVEGLSR
                     MVIVTHGDEWAMEQVQKQLYKLVDVIKVNDLSDHPAVERELLLIKVGAGPTTRMEISGV
                     VEPFRASVVDVGPNSMMVQATGERAKLDVLIELLRPYGIKEIARTGVTALSRSMAHASV
                     "
     gene            complement(11937..13619)
                     /gene="ilvB"
                     /locus_tag="BLV90_RS08930"
                     /old_locus_tag="SAMN05444487_10814"
     CDS             complement(11937..13619)
                     /EC_number="2.2.1.6"
                     /GO_component="GO:0005948 - acetolactate synthase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003984 - acetolactate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009097 - isoleucine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009099 - valine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ilvB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017811378.1"
                     /locus_tag="BLV90_RS08930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_10814"
                     /product="biosynthetic-type acetolactate synthase large
                     subunit"
                     /protein_id="WP_245726309.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 7.4e-57, bitscore:
                     184.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3e-51, bitscore:
                     166.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTGSEILLRCLIEEQVEILFGYPGGSVLPIYDSLYQGELRHMLA
                     RHEQGAIHAADGYARATGNPGVVIATSGPGATNLVTGIATAKMDSIPMVCITGNVPQQL
                     MGTDAFQEADIMGITMPIVKHSYLVTDVRDLPRIVKEAFHIASTGRPGPVLIDIPKDVA
                     NAKDKFHYPEAVSIRGYQPTSNPHPLQLARLRKEIAEAKKPVILAGGGVVISGAEKELM
                     EFAEQAQIPVITTLMGLGGFPGKHPLWLGMPGMHGTYAANHALLETDLLIGIGARFDDR
                     VTMGRPDIFATKAKIVHIDIDPAEIGKNVDTFIPIVGDVKKVLQGAVNDDLLRSDCADW
                     IDKVQGWYKSYPLQYQDSEEILKPQWVIRHLYETTGGDAIVTTDVGQHQMWVAQYFQFA
                     QPRSLITSGGLGTMGFGFPAALGAQLGKQERTVISVIGDGGFQMTNQELAIASSANIPV
                     KVVIINNQNLGMVRQWQEVFYKKRYCDVDLSGSPDFVKLTEAYGVKAWRATTKEEAIHA
                     WAEALAHPGPAIVDFWVAPEENVFPMVAPGKGLDEMIMGDEEE"
     gene            complement(14327..16021)
                     /gene="ilvD"
                     /locus_tag="BLV90_RS08935"
                     /old_locus_tag="SAMN05444487_10815"
     CDS             complement(14327..16021)
                     /EC_number="4.2.1.9"
                     /GO_function="GO:0004160 - dihydroxy-acid dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009097 - isoleucine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009099 - valine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ilvD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018976250.1"
                     /locus_tag="BLV90_RS08935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_10815"
                     /product="dihydroxy-acid dehydratase"
                     /protein_id="WP_091739522.1"
                     /transl_table=11
                     /translation="MGTSDNDKKDLRIRSHVISEGANRVPNRAMLRATGFTDEDFKKPM
                     IGVASTWSEVTPCNMHIRELAEEAKRGAVEAGGAPMIFNTITVSDGISMGHEGMHYSLP
                     SREVIADSIETVIGAERLDAYVAIGGCDKNMPGCMIAIGRTDVPAVFVYGGTIRPGNLD
                     GKDIDIVNAFEGVGKYNKGALDREGLHDIECHACPGAGSCGGMYTANTMSSAIEALGMS
                     LPGSSSNPAETKDKLEDCRAAGAAAVELLRKEIYPRDIMTKEAFENAITVVMALGGSSN
                     AILHLLAMAHSIDVELTMDDFEQIRQRVPHIADLKPSGRFVMQDLYEAGGVPAVMKVLL
                     EQGLLHGDCITVTGKTLAENLAEAEPLREGQEVIRSFDEPFRETGPLVVLEGNLAPEGA
                     VAKVSGLKVSQLTGPARVFDSEEAATEAILSDQIREGDVVIIRYEGPKGGPGMPEMLSV
                     TAILVGKGLGEKVALLTDGRFSGGSHGFVIGHIAPEAQVGGPIALVHDGDMVTIDSVKR
                     ELSVALSEEELAARRADWKERPLPVARGVLNKYSRLVSSASRGAVTD"
     gene            16279..16701
                     /locus_tag="BLV90_RS08940"
                     /old_locus_tag="SAMN05444487_10817"
     CDS             16279..16701
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024854.4"
                     /locus_tag="BLV90_RS08940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_10817"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_177167971.1"
                     /transl_table=11
                     /translation="MSNRTQLTQDTIQAFQFVIRKLRRGIQQQLEENWGISDFIFLHHL
                     LTHGPTKGSDLSTELNVTNSHVTQQVNRMVKKGWISRHRSDVDKRVVELEITPSGKEIH
                     AEMEERRFQYFKQQFRSLTDEELKTLLNLFYKLTDE"
     gene            16715..18256
                     /locus_tag="BLV90_RS08945"
                     /old_locus_tag="SAMN05444487_10818"
     CDS             16715..18256
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006834758.1"
                     /locus_tag="BLV90_RS08945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_10818"
                     /product="MDR family MFS transporter"
                     /protein_id="WP_177167972.1"
                     /transl_table=11
                     /translation="MEHLANKQKITIMLASMASMLFASLNQTIVGTALPHIVSQLGGMK
                     YFNWVFTIFMLTSSITAILVGKLSDMYGRKPFILAGLGTFIIGSFLCGTSTDMFQLIAY
                     RGLQGFGCGMIISTSFAAIGDLFPPRERGRWQGAMTATYGLASVIGPTLGGYIVDNFNW
                     EWVFWIFLPVGAIAFFFIWRMFPQATQRNHTSIDYAGSVFLTVTIVPLLLAFSWAGRDY
                     AWSSLTILALFAISLISLALFIWIENRAENPVLPLHLFKISSFNLANIIVFLIGMGMFV
                     VIMYMPFYIQGVMGISAEKTGLFMMAITLSMVVSSVLSGQIISKTGKYKKLGLLGLLFM
                     GSGMFLLSTMNPGTSHLILGGYLALTGFGLGLSLSLYNLVSQNSVPQSHLGVATSASQL
                     FRQMGGTIGVSIMGGIMLTRMQSRISSSLAQAPESFSKLTALKDPEILLSPDKLATIKA
                     ELPANLNTSFTQLLHHLREAMGFALDGVFLTGSGILAFAFLLACFLKEIPLRTSN"
     gene            complement(18451..19101)
                     /locus_tag="BLV90_RS08950"
                     /old_locus_tag="SAMN05444487_10819"
     CDS             complement(18451..19101)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020893.4"
                     /locus_tag="BLV90_RS08950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SAMN05444487_10819"
                     /product="TVP38/TMEM64 family protein"
                     /protein_id="WP_091739528.1"
                     /transl_table=11
                     /translation="MVIKKNLSIILLLILLALGACIFLFLDLRQLSPESIRYFVLSFGV
                     WAPILYLLMHVMRPLFLVPAVVLAVASGITFGPWWGTILDVIGSLGGAMVAFTLARWLG
                     KETVSRWLGSYARWEKWMVDEGFRTIFLLRLIPILPFDAVSYGAGFSRTGARDYYLGTL
                     IGVLPGAFVFNYLGYSLHDLFSPVFFASLGGALLLAISPWLFRRFSRSFVKQK"
ORIGIN
        1 ttcaatgaag tcagttgggc agaacaggtt ccataggtca gaccttttcc tgtgctgtca
       61 taggattcgt tccatctggc tagaaagtga ttaaaagtga agcgactaca accgatagat
      121 ttattgatga gattggtttg ttccttcgtt ggacacaaac gaaatttaaa cgctttgtgc
      181 attagctcac ctcccctata cttaattata tacggggata gccgaacttg cgagagggaa
      241 aaaactcccc ctccctcgtt cgacgcgcct tatatcccat aggctgaagc caggggtttt
      301 acgggcgctt tctattattt cacatgagtg gaaggcggat cgtcaacatg cgatcagtgg
      361 ggtcggcatg ggtttccatc cgcgacactt ccacctttcc cggcagaagc atctcataga
      421 caaaggcgga ttcctccact gaatctgttg accctgtcgt tccacgaacg attagaatct
      481 gcccttcgac tcggacatcg atttcgtgcc gctcccgaag tccgggaatc tcgatcataa
      541 cgatcaacat cccatccttc tggtagaaat ctccatgtat ccgattctgc tctaactctt
      601 gagagagtcg ttgcatctga agaaaaatct ctcccaccca atcctcggga cccttcgcta
      661 accacggccg caacatcccg atcctccttt cctactagga aattaccccg ttgagggttc
      721 tcccactagt aatgtttaat agtaaggccc accacaggag ctccaccacc agaagattgc
      781 aaagaagatg aagaggatga agattactgc aagcgcgatc cagatgcctg aaaaccatcc
      841 tcctccaaag ccaccaaaat tacctccacc cttagtatgt gctttagtca tcgacttccc
      901 acctcctccc ctcccacaca acggctcggt atagggtatg tgcgaagtac ttttctggta
      961 tggatagatg cccggacttc acaaaaaagc gcccgcaaat ttgcgagcgc gttgagtcca
     1021 atgatcatca tgcattgatc acagtagacg aagaaactct ttcataaacc caggcaaatc
     1081 tggccaagca tgacctgaaa ccaagttgcc atccgtatgt aaaggctcct ctatataccg
     1141 ggcacctgta gcttccactt cgggacggca gttagaaaag gcggtaaggg aacgaccctt
     1201 tagaacatcg ggtactacat taaagactaa cgtagcatgg cagatggcac ctacaggctt
     1261 atttgtcgta aagaaatggc gtacgatatc cggtaacttc ccatgcattc ggatatgctc
     1321 gggtgcccgc cctccaggaa tgatcagccc atcgtaatct gtcggattaa tctcatcaaa
     1381 ggaaatatgg ctatctagcc cataagcatg tttttctgta aaggtatcta tatgaggctc
     1441 aaaatcgtgc acgactgttt gtagtctctt cttagttggt gcagcaatga ctgcttcatg
     1501 tccctcttct agcagtcgat aatagggata aaacacttcc aatgcctcaa cagcatcccc
     1561 agtcagaatc aaaaccttcg ccataattaa accctcccgt acatttttta ctcgcaagat
     1621 atatatattt cctgtaattg attccgttaa acctccgttg actcaaaaca ttgtgttaaa
     1681 atatgcttat ctcgtatgaa aggtaggaat catccagtgt gatctccatt caattttcac
     1741 tacacgcctt ctcagatcaa tcactcacat gggcagtata actttccatg accacaaacc
     1801 ttctaaataa aaatggagat tacctactta tgaatagatt cccactatct ttccgtgcac
     1861 tatggttagg acaaggagta gccaaccttg ccgattcctt ttatattatc gcaatcgtca
     1921 cgttgctata taatttgagc ggttctgcaa caatggcggc atccattccc cttttacgtg
     1981 taggagcaca gatgaccagc ggttttatcg ctccgctact tctgcatcga tttcctttac
     2041 atcgcatcct tctcacatcc caaacaggtc agacttttct gctcatcatc ctcgccacga
     2101 tgatcagttg gttgaaaagc ccacttccag ggttagccct agtctttggt acctcctttc
     2161 ttgatggctg gacaacacct gcacggaatg ccttggtacc aagacttcta cccactgatt
     2221 ccctcatccg tggaaacagt tggctcgcta ccacagatca aaccatcatg ctcctcggct
     2281 ggtctaccgg cggactgctt gttgcttact tgggaagtag ttctctctta tggatatccg
     2341 tcgggctttt tattatttct tgcctagccc ttacgccggt gcgagatcct gagccaaaaa
     2401 atgatggacc tgaaaaacga cctccacgct ggcacattat gaaagaaggt tggtccacta
     2461 ttcttaacaa ccctaccctc cgtcgcatta ctttgatgga tgttatcgag actgcgtcgg
     2521 gcacgatatg gatcggtgcg atcatccttg tattcgtaaa agaaatcttg caccgcggag
     2581 aaacttggtg gggatggatt aatgctagtt actacacagg tactgtgtta ggcggcttgc
     2641 tcatcctgac gctttctcgt ctgttcgctc atcgattggt tctaggaatg atcatcggat
     2701 ctgtgtgcaa tagtgtgttg acccttttat tcgcgctgtt acctgtccct atcgtatctt
     2761 tggttcttag tatcctgatg ggaccctgct accaactacg cgatatcacc caacgaaccc
     2821 tttttcagca ggctctctca tctgaaacga ctccaaaagt cttcgctgcc catggaacct
     2881 taatgtacgg tgtatttggt ttagcggtat ttgtcacggg tgttgtggca gactcctttg
     2941 gagttcgatc tgtttaccta gcaaccgctg gtttattggc ttgctcagta atgatcggga
     3001 ctcctctgtt gcgtagcaat aataggagtt cttcagagtc aacatgccat tcaagcagag
     3061 gctaaacaaa agcaggcgaa ccatcacggt tcacctgctt ttcttatcat tataggaaaa
     3121 gaaccttaat caaaccaacc cttactctta aaccacattg tcaaactcaa agcaattaga
     3181 atcatcactc ctaagacaat aaaataacct tcttttgtat gcaactctgg catgttcgta
     3241 aagttcattc cgtaaacacc cgccaagaaa gtgagcggca taaaaatcac ggtaataata
     3301 gtaagcgtct tcataattcg attcatacga aaagagttaa gggagagata actatcccga
     3361 atatctgctg tcatctcccg attagattcg atcatgtgag caagttttac taagtggtca
     3421 tggatatcac taaaataaaa gcgacgctct tccgttctca taaattgctt ggagttgata
     3481 atccgataca aaagatctct catgggcatc acactatggc gaagccggat caaatcactc
     3541 cgaatagtaa acacttcatc aatcaacttc ggtgttgaag cttcttgacg actatctagt
     3601 tcatctaaac gatcttcgat cttatgtacc accgggaaca aagtatccac gattttatcc
     3661 ataatcatat gggtgatcac agtaggacca tgattcgata agtcctgcgc cttaaagaca
     3721 cgacgccggg tctcctctat ctcgtctgaa cgatgaagat ggaagctgac gataaagttc
     3781 tcaccaacaa acaaattgac ctccttcggc ttcaaggtgt ccgtattcat atcatgaact
     3841 atgaggaaga catgatcatt ataatagtcc atctttggac gttggagacg atgaagacaa
     3901 tcttcaatgg ctaatggatg aaattcaaaa aaatctgcta gtaaattcgc ttcttcctcc
     3961 gtcggggtag caaaatctac ccaataccat ttaatccgat cctcttttaa ttgagctaac
     4021 tccaaatcaa ggagtgcttc ttcgtcacag gtaacagcta gtgtatgaat cattcaatcc
     4081 ctccgggttg gaacacaact ctatcgaaat gcatccttga atttttctag tgtagaagag
     4141 gctttctaca tagaaagccg actttttaat tgttcccgta aggcccgttt taaaaacttc
     4201 cctactgagg atttaggtag ttcatccatg aagatgactt catcaggtag ccaccatttt
     4261 gccacagaag gcctcagaaa ttcaagaata acttcggctg tgatctcctc ccggtaacct
     4321 tcctttagaa ccacacaagc cactgggcgt tcctgccact tctcatgggg catagcgact
     4381 acagctgctt catatacccc ttcatgggcc atgatcgcat tttcaagatc cactgaactg
     4441 atccactctc caccactctt aatcagatct ttggtgcggt cagcaatctt tatcgttccc
     4501 tctgtatcaa tagttacaac atcccctgta tgaaaccatc cttcacggaa ggaatcagtt
     4561 gaacgatccc ctttatagta cccatcagca atccatggac cgcggataag caactcaccc
     4621 atctcttccc catcccaggc aatctcttta ccatcggggc ccagtgcacg tacttccaaa
     4681 ccaggggaga caaccccttg cttcgcctta atcgctaatc tctcctctag cggcaaatcc
     4741 ttttgatagc tttttaagtg agagacggtc acaatggggc tagtttcggt cattccatag
     4801 gcatgaacca ctggaattcc atgcttctct tcaaaggcac ggatcatgct aggtggggca
     4861 gatgctccgc caaataacaa catacgtaga ctggagagat catagctctt cgtctccaat
     4921 tcctttagaa gagacatcca gatggtaggc acaccacctg tcacggttac cttctcagac
     4981 tggatcagat tggcgatcac atccgctttc atcatcggcc ctggcatcac ttgtttagcg
     5041 ccaaaccaag tagcagcaaa gggaagcccc catgcgttca catggaacat cggcaccaca
     5101 gataggcaag tgtccccctc ggatagaccg accgtgtcag ctaaacccga aatcatactg
     5161 tggagataga tactacgctg ggtataaaga acacccttag gcatccccgt tgtcgccgag
     5221 gtataacaca ttcccgcagg agaattttcg tcgagatcct tagggtaaac aaactcagga
     5281 tttccttggg ataataattc ttcataggag tatagcggag atagattggt ctctggcaat
     5341 tcagactgat ctgtcattat aataaaggct tccaccgtag ttagctcgtc acggatggct
     5401 tcaataagtg gcaataggtt atcatcaata agcagtatgc gatcttccgc atggttgatc
     5461 acataagcta gatgttctgg ggagagtcgc aggttaattg tatgcagaac ggctcccatc
     5521 gatggaatcg caaaatatgc ttcgagatgg cggtaatggt tccaggccaa tgtgccgacc
     5581 cggtccccgt tattgattcc gagcttttgc aatgcgttgg agagccgtcg tgcacgaaca
     5641 cccatctcag cataggtctc acgatgcaat cccgaaggag tacatgagac aatctccttc
     5701 ttcggaaaca cgcgctcagc acgctccaac ataggggaga tcaatagtgg cacgttcatc
     5761 atagcgcttt cccgcctttc agattggttg taggattctt cgtccattat actagatcca
     5821 atctacatta aaaacgcttt caaaaggatt gaaaagagaa tttgtttcaa tgaacctgtg
     5881 tttagaagga gatcacttgt gatgatctcg atatactcct attgagaatc accctttctc
     5941 catccccttt acccagtcgt gctcccaccc taaaagacgc cggatacaac ggtggttctc
     6001 tgacatagtg gaaaaatgat gagcaagggc ttcctgaact aacggcaaag ggaaaagatt
     6061 cctctctacg acggcagcct ccgcatgccc taagagtgag cgataaaagg tcacatcttc
     6121 acttgtatcc ccacaaggac aaggcacctt ctccacatgt gatccgagta gatccacgct
     6181 gctcgctaat tcctggcgca ctttttcagc taagtccaga tcccagtact cgtgatacaa
     6241 ttcttcgagc gcattgagag cgtggaggtg agcaagccac ccttcattaa tcgccacaga
     6301 acatcttcct ttctacttgt ttttacatcc gataactcgg gtttattggt catattattc
     6361 cgtcaattaa ccgttcataa accccttttt tcttaataat aaaaaactgc agatcagcct
     6421 atgcatcatt ttaaaccagg ctatccacag ttttatatca tttacatttt tatagagtca
     6481 tttgacatca ttgcttctac gggaatagta ggatctggct gatatttctt aagagcttca
     6541 actactttgt cccctacctc ctcggtagat agcgccaaac tttccgtaga cgccatatcc
     6601 atcgtccgtg ctccagaggc gatgacatcg ttaacggctc cctcgatggc ctttgccgcc
     6661 gcatcatcat ggaaagagta gcggaacatg agggcgacgg agaggatggt agcgatggga
     6721 ttggctactc cttgtcccgc gatatcggga gcggaaccat gaacaggctc atataggccg
     6781 cgatgccctt cacctaggct agcagaaggt agtagcccga tggatcctgt aagaatagcc
     6841 gcttcatcac taagaatatc cccaaacata ttttctgtga cgataacatc aaagtccgcg
     6901 ggtcgacgaa tcatctgcat cgcacaatta tcaactaaaa gatgatccag ctccacatcg
     6961 ggatattcct tcgctactcg ttccgcaacc ttgcgccaca ggcgtgagct ttcaaggaca
     7021 ttggctttat caaccgaggt aaccttcccc cgtcgtacct gagcaatctc aaaggcacga
     7081 cgaacaatgc gctccacctc aacctcagtg tataccagtg tatctgtcgc ccgttcacca
     7141 gcaggggttt cctcagtaaa tttctcacca aagtagatcc cccctgtcaa ttccctgaca
     7201 accagaaaat ccaccccttg caatacttct gctttcaagg tggaactctc ttctaaacca
     7261 ggaaagagag tagtaggccg aagattggca aagagatcga gttcctttcg cagtccgaga
     7321 agcgcttttt ctgggcgcaa ttctggggga ttgcgatccc agctaggtcc acccaccgct
     7381 ccaagcaata ctgcatcggc ttgtttacac agggtaagcg tctcttcggg taatggattt
     7441 ttcaatcgat caatcgctga acctccgatc cagccaaagt cgatttgaaa ggtgtagccg
     7501 aaccgttctc cggtggcttt catcactttg gcaccttcat ccgtgatctc tggaccaatt
     7561 ccatccccag gtagaaaagc tattcgcttc ggggctgcca tgattgccac tcctttcgct
     7621 cttctcattc acctactgcg ggtgcaatct ccttttgttt cttctgccgg ttccgcattg
     7681 aaagtaatcg attaattcca tggatatagg cccgggcact tgcctccaat atatccgtgg
     7741 agacgcctcg tccctgtacc gttatatcag aatcatcatc atgcagtttc acatacacct
     7801 cacccaagga gtccgtgcca tgggtaaccg atacaatttt ataatctgca agattccagg
     7861 attcattggt gatgcgatca actgccttaa agatcgcgtc cacggaccca tttccacatg
     7921 ctgcttcctc caccttcagc cccattcggt tatccatgag acgtagggaa gcagtcggaa
     7981 cggattgact cccataagcc acttgtacgg tctcaaaggt aaacacttct tcttcctctt
     8041 ctccaattcg ctcttcgatg agggaaacca gatcctcatc ttcgatcacc tttttccgat
     8101 ccgtcaactc cttaaatcgg tggaatagct gattgatctg ttcgtcatta aaagcatagc
     8161 cgaattgtga taatttatcg cggaaagcat gacgtccaga gtgtttaccc agtaccaaca
     8221 aggtattcga ttgacccact gtttctggat tcatgatctc ataggttgca gcatttttta
     8281 gcatgccatc ttgatgaatc cctgactcat gggcgaaggc attggttcct acgacagctt
     8341 tattcccagg aacaaacatc cccgtcattt tggaaatcaa tcgacttgtg cgagcaattt
     8401 cagacaattg aagatccgtc tccattccat aataagaagc tcgagtgtac aaagccatcg
     8461 caacttcctc tagggcaaca tttccggctc gctcaccaat cccgttgatc gttccttcca
     8521 cttgttcggc acctgcttca attgccgcca agctattggc cgtcgccatg cccaaatcat
     8581 cgtggcagtg ggctgacaac tttacctttt caatccctgg aacatgggtc tttatatacc
     8641 gaaatatatt gccatattcc tggggtgaaa gataaccgac agtatccgga atgttgatca
     8701 catccgctcc cgcgtcaatc gctcgcttga ctacctcaca gagaaaatcc agctcagtac
     8761 gcccaccatc ctctgctgaa aattccacat gggagaaaaa cagtttcgca taccggacag
     8821 catcttctgc ctgatttaga acttcctcct tcgtcatgtt taacttatac tccctatgaa
     8881 taggggaagt cgctatgaac acatggacgc cagggtttac tgctgtcttc aaggcctccc
     8941 aggccgcatc aatatcacta cgaactgctc gggcaaggct gactacagtc ggattctgta
     9001 ccgcctctcc tactttccga actgcctcac gatctccagg ggaggaggcg gcaaatcctg
     9061 cttcaatcac atggatgccc aatttttcaa gctgaagggc gatcgccacc ttctcttcta
     9121 catttaggtt tactcctggg gactgctcgc cgtctcgtaa tgtcgtatca aaaaattgga
     9181 catttcggcc cataccgcat cctccttcta attcagttca ggcttttacg ctgttctttt
     9241 ggttgatcca tgccatggtt tctcgtagtt tagcacctgt cgtctctaac gaatgctggc
     9301 tttcctcttc acgcatccgt aaaaactcat gaccaccact ctcattttca gcaatccatt
     9361 ttttagcgaa gctaccatct tggatctcct gcaatacttc tttcattgcc gtccgggatg
     9421 catcgcctac gactcgcttc ccacttacat aatcgccgta ctccgctgta ttactaatcg
     9481 agtaccgcat tcctgcaaga ccttcttcat acatcagatc cacgatcaat tttagttcat
     9541 ggaagcactc aaagtaggca atctccggtt ggtaacctgc ttcgatcaag gtttcataac
     9601 cgtttttcac caaggaactc actccaccag cgagaaccgc ttgttcacca aacaggtccg
     9661 tctccgtctc ttctttaaaa gtcgtttcaa tcacacctgc tcgggtcgcc ccaattccct
     9721 ctgcataagc taggcctatt tccgttgctg atccactagc atcttgctga acagcgatca
     9781 atgcaggaac tccaaagcct tcagcataaa ctcgtcgtac gagatgacca ggcccctttg
     9841 gagcaattaa tgccacatcc acattgcttg gaggctggat ctgctcaaaa tggatgttaa
     9901 acccatggga gaaaaagagc gcggaacctg gcttcagatg cggttctact tcttccttgt
     9961 agacacgagg catgatttca tcaggcatca agaggttgat caaatctgcc tgttttacgg
    10021 cttcagccac ttccaatacc gtgaagccat ccttttctgc tttctcccag gatttcccct
    10081 tccgaaggcc aaccactacc tggactccgc tatctcgtag attttgtgct tgtgcatgac
    10141 cttggcttcc ataaccgata attgccacgg tttttcctgc tagattcttg ctgtctgcgt
    10201 ccttcgcgta atataccttt gccatgaata aaatcctcct aaagtttagt aatgaaggtt
    10261 tttgtaaacg cccttgccag tctgtttttc aggatttgcc gcctcaccct tacggtatta
    10321 aggagattgc tcgaaccagg agtgaccgca ctctcacggc tcataccgcg cattccttcc
    10381 gatttagttc aggctttacc cttctaattc agttcaggct tttacgcttt tcttttggtt
    10441 gatccatgcc atggtttctc gtagtttagc acctgttgtc tctaacgaat gctggctttc
    10501 ctcttcacgc atccgtaaaa actcatgacc accactctca ttttcagcaa tccatttttt
    10561 agcgaagcta ccatcttgga tctcctgcaa gacttctttc atcgccgtcc gggatgcatc
    10621 gcctacgact cgcttcccac ttacataatc gccgtactcc gctgtattac taatcgagta
    10681 ccgcattcct gcaagacctt cttcatacat cagatccacg atcaatttta gttcatggaa
    10741 gcactcaaag taggcaatct ccggttggta acctgcttcg atcaaggttt cataactgtt
    10801 tttcaccaag gaactcactc caccacagag taccgcttgt tcaccaaaca ggtccgtctc
    10861 cgtctcttct ttaaaagtcg tttcaatcac acctgctcgg gtcgccccaa ttccctctgc
    10921 ataagctagg cctacttccg ttgccgatcc actagcatct tgttgaacag cgatcaatgc
    10981 aggaactcca aaaccttcag cataaactcg tcgtacgaga tgaccaggcc cctttggagc
    11041 aattaatgcc acatccacat tgcttggagg ctggatctgc tcaaaatgga tgttaaaccc
    11101 atgggagaaa aagagcgcgg aacctggctt cagatgaggt tctacttctt ccttatagac
    11161 acgaggcatg atttcatcag gcatcaagag gttaatcaaa tctgcctgtt ttacggcttc
    11221 agccacttcc aataccgtga agccatcctt ttctgctttc tcccaggatt tccccttccg
    11281 aaggccaacc actacctgga ctccgctatc ccgtagattt tgtgcttgtg catgaccttg
    11341 gcttccataa ccgataattg ccacggtttt tcctgctaga ttcttgctgt ctgcgtcctt
    11401 cgcgtaatat acctttgcca tgaataaaat cctcctaaat agtctgtttt atacactagc
    11461 atgagccata cttcgtgaga gtgcggttac tcctgttcga gcaatctcct taataccgta
    11521 aggacgtagc aattcaatca gtacatcgag cttggctcgc tcaccagttg cctgcaccat
    11581 catactgtta ggccctacat cgactaccga tgcccgaaat ggttccacca caccagatat
    11641 ctccatgcgc gtagtaggtc cagcccccac tttaatcaag agaagttccc tctccactgc
    11701 agggtgatcg gacaaatcat ttactttgat tacatcgact aatttgtaga gttgtttttg
    11761 cacttgttcc atcgcccatt catctccatg ggtgacgatc accatacgag ataagccctc
    11821 tacttcggat tcccctacac taatgctctc gatattgaaa ttacgaggac cgagaagtgt
    11881 agttactcgg gcgagtactc gaggttgatc attaactaat acagatagta catgtctcac
    11941 tcttcttcat ctcccatgat catttcatcc agccccttcc ctggagcaac catcggaaag
    12001 acgttctctt ctggcgcaac ccagaaatcg acgattgctg gtcctggatg ggccaatgct
    12061 tctgcccagg cgtgaatggc ttcttccttc gttgtcgccc gccacgcttt tacgccatag
    12121 gcttctgtca gttttacgaa atcgggactt cctgagaggt ctacgtcgca atatcgcttc
    12181 ttataaaaaa cctcttgcca ttgtcgtacc atcccaaggt tttgattatt aataatgacg
    12241 acttttactg gaatattggc tgaagacgcg atagccagtt cctgattcgt catttggaat
    12301 ccaccatcac ctatgacact gatcactgtt cgctcttgtt tacccagttg tgcaccgagt
    12361 gcggccggaa aaccaaagcc cattgtgcca agtcctcccg atgtaataag agaacgcggt
    12421 tgtgcaaact ggaagtactg ggctacccac atctgatgtt gccctacatc cgtcgtaaca
    12481 atcgcatccc cacccgttgt ctcatataga tgacggataa cccattgggg cttcaagatc
    12541 tcttcggaat cctggtattg aaggggatat gatttatacc atccctgcac tttatcaatc
    12601 cagtcagcgc agtcacttcg cagcagatcg tcatttacag ccccctgtag tacctttttt
    12661 acatctccca caatgggaat aaaggtatcc acgtttttgc ctatctctgc tggatcgata
    12721 tcgatatgca cgatttttgc cttcgttgca aatatatcgg ggcggcccat cgttactcga
    12781 tcatcaaaac gagcaccgat cccaatgagt agatctgttt ctagcaacgc atggttcgca
    12841 gcataggtgc catgcatccc tggcatcccc agccacaggg gatgctttcc tggaaagcct
    12901 cccagaccca ttaaggtagt gattaccgga atctgtgcct gctcagcaaa ttccatgagc
    12961 tctttttcag cacctgatat caccacacca ccacctgcga ggatgactgg ctttttcgct
    13021 tccgctatct cttttctaag ccgagccaac tgcaaggggt gtgggttcga tgtaggctga
    13081 tatcctcgaa tggataccgc ctcaggataa tggaatttgt cctttgcatt ggcaacatcc
    13141 ttcgggatat cgatcaacac agggcccggt cgtcctgtac tcgctatgtg gaatgcttcc
    13201 ttcacaatcc gtggaagatc gcgtacatcc gtaaccaggt aactgtgttt aacgatcggc
    13261 atcgtaatcc ccataatgtc tgcttcctgg aaggcatcgg ttcccatcaa ttgttggggt
    13321 acattccctg taatgcaaac catcgggatc gaatccatct ttgctgtggc aatcccagtc
    13381 acaagattag ttgcacctgg acccgatgta gcaatcacta cccctgggtt ccctgtcgct
    13441 ctcgcatatc catctgcggc atgaatagct ccctgttcat gccgagccag catgtgtcgt
    13501 aattctcctt ggtacaagga atcatagata ggaagcaccg atccccctgg atagccaaac
    13561 aagatttcaa cctgctcctc tatcaaacat cgaagtaaaa tttccgaacc agtatacatg
    13621 gtttctggtg actcggcact tttcgtatgt ccgcctagta ccgttgctgt ttggcccatc
    13681 caaataacct cctaaaatca ttgtgctata taaaaaccct tcgcccatca actaaagaca
    13741 atctacttct gtcataagtt gattggggcg aagggttcgc ggtaccaccc aatattacca
    13801 tcgcctcacg gcgaacggac ttagcgggtg ctccttgtaa agaagcatcc tgatcgggta
    13861 acggtgatca tccggtcacg ttctactcag ggaactcccc tttcgacgcg cagctccgag
    13921 gtgagtaatg ccttggatcc aatatcccag tttcagctaa tctgggactc tctgtgatct
    13981 ggaagtccaa agggtatggc ctcttcatcg cattgattta attgatagaa tattatatat
    14041 tttctgcttc aaaaagcata taagaaaccc ctggagaaaa tccacacctc tctaacttca
    14101 atcgaggtag gaccttccgc agaggcttct atcctcacgg tgtacaccat tcggtgttgg
    14161 tatcactcgg tcgcagtcct cgctaatcta gcgagcggaa ccctagatac cctcccaact
    14221 taactcgtag agaccatttc ataaaagcaa ctagttgaat tatttaggtg ctattatagg
    14281 catgccgttc accctttgtc aaccggttca tacaaaaact tttttatcaa tcggttacag
    14341 ctcctcgaga cgccgaagag acgagacggc tgtatttgtt aaggactcca cgggcaaccg
    14401 gaagtggacg ttctttccaa tcagctcgac gcgcagccaa ttcttcctca gagagagcaa
    14461 ccgatagttc acgtttaact gaatcgatgg ttaccatgtc cccatcgtgt actagagcga
    14521 ttggtcctcc cacttgtgcc tcaggggcaa tgtgcccgat gacaaacccg tgggaccccc
    14581 ctgaaaaacg accatcggtt aaaagggcaa ccttttcccc taagccttta ccgactagta
    14641 tcgctgtaac ggaaagcatc tctggcatac caggtccacc cttgggacct tcataacgga
    14701 tgatcactac atctccttca cggatctgat cggacaagat cgcctctgtc gccgcctcct
    14761 ctgaatcaaa gacccgggct ggtccagtca attgactcac ttttaagccc gacaccttgg
    14821 ctactgcccc ttcaggtgcc aaatttcctt ccaagactac caagggtcca gtctcccgga
    14881 aaggctcatc aaaggaacga atcacttctt gcccttcccg aagcggttct gcctcagcaa
    14941 ggttttctgc caatgttttc cctgtcacgg taatacagtc cccgtgaagt aatccttgtt
    15001 ctagaagaac cttcatcact gcaggcactc cgccagcttc atacaaatcc tgcatcacaa
    15061 atcgacccga aggcttcaga tctgcaatat ggggaactcg ttgccgaatc tgctcaaagt
    15121 catccattgt caattcgaca tcaatcgagt gggccatagc caataaatgg aggatagcat
    15181 tggaggagcc tcctagagcc atcacaacgg taatcgcatt ctcaaaagct tctttggtca
    15241 taatatcccg cggataaatt tctttacgca gtaattcgac agcagcagct cctgccgccc
    15301 gacaatcctc taatttatcc tttgtttctg cgggattgga agagcttccc ggcagactca
    15361 tccctagtgc ttcaatcgct gaagacatgg tatttgctgt atacattccc ccacaggacc
    15421 ctgctccagg acaagcatga cactcgatat catgtaaccc ttcacgatcc aaggcacctt
    15481 tgttgtactt acctacccct tcaaaagcat tgacaatatc aatatctttt ccatctaaat
    15541 tccccggtcg gatcgtccca ccgtagacaa aaaccgcggg tacatccgtt cgcccaatag
    15601 ctatcataca accaggcata tttttgtcgc agccaccaat tgcgacatag gcatcgagcc
    15661 tttccgcacc gatcactgtc tcaatggaat cagcaatcac ttcccggcta ggtaaggagt
    15721 agtgcattcc ctcatgtccc atagaaattc catctgaaac ggtaattgtg ttaaagatca
    15781 tcggtgcgcc tcctgcttca accgcacctc gtttcgcttc ctctgccaat tcgcgtatat
    15841 gcatgttaca tggtgtcact tctgaccaag tgctcgcaac accaatcatc ggcttcttaa
    15901 aatcttcgtc cgtaaatccg gttgcccgga gcatcgcccg attggggacc cgatttgccc
    15961 cttcactaat cacatggctt cgaatacgta gatctttctt atcattatca gatgtgccca
    16021 tctctcttac ctccttaata tctgtaaaat ttttcagttc attataaagg aatatgtgga
    16081 agatgcagtc atttctctta cctccttaac atctgtaata ttttgcagat cagtataaag
    16141 gattgcgtag cggatgtcac gcatatttaa taactccttt aaaccaatga ttgacataaa
    16201 ttaaccctct tagtacaatg ctatcatata caaaagttaa ccttattaac tattagagag
    16261 ccgagaggtg ggctaccctt gtcaaacaga acacaattaa cccaagatac gattcaagca
    16321 tttcaatttg tcatccgcaa acttcgccgc ggtattcagc aacaattaga ggagaattgg
    16381 gggatttctg attttatctt tctacatcac ttgcttactc atggacctac caaaggatca
    16441 gatctctcca ccgaactgaa tgtaaccaat agccatgtta ctcaacaagt gaatcgcatg
    16501 gtaaagaaag gatggattag tcgtcaccgc tccgacgtcg acaaacgcgt agtagagctt
    16561 gaaattactc cctctggaaa agaaattcat gccgaaatgg aggagcgtcg atttcagtat
    16621 tttaaacaac aattccgctc tttaacagat gaagaattaa aaacccttct taatcttttc
    16681 tacaaactaa cggacgagta ggagatgact tcttttggaa caccttgcaa ataaacaaaa
    16741 gattacaata atgttagcca gcatggcttc catgttattt gcttcactca atcaaaccat
    16801 cgtaggcaca gcacttccac acatcgtgag ccagttgggt ggaatgaagt attttaattg
    16861 ggtctttaca attttcatgc tcacatctag catcacggcg attcttgtcg gaaaactatc
    16921 tgatatgtat ggtcgtaaac cttttatcct tgctggattg ggcactttta ttataggctc
    16981 ttttttatgc ggaacttcaa ccgatatgtt ccaactgatc gcgtatcgtg gactccaggg
    17041 atttggttgt gggatgatca tctccacctc ctttgcagct attggagatc tatttccccc
    17101 tcgggaacgt ggacggtggc agggagcaat gaccgctacc tatggcttgg caagtgtaat
    17161 cggccccact ctaggtgggt atattgtaga taattttaat tgggagtggg ttttttggat
    17221 ttttctcccg gttggtgcta tcgccttctt tttcatctgg cgaatgttcc cacaagccac
    17281 gcaacgaaat catacatcga ttgattatgc aggctccgta tttctcacag ttacgattgt
    17341 ccctctcctc cttgccttta gttgggcagg aagggattac gcctggtcat cactcaccat
    17401 tcttgccctc ttcgccattt cccttatatc tctggctctc tttatctgga ttgagaatcg
    17461 agcagaaaat cctgtattac ctcttcattt atttaaaatt tcttccttca acctagctaa
    17521 tatcatcgta tttttaatcg gtatgggtat gtttgtagtc atcatgtaca tgccttttta
    17581 tatacaaggt gttatgggaa tctcagcaga aaagactgga cttttcatga tggcgatcac
    17641 cctttccatg gttgtctcta gtgtgctaag tgggcagata attagtaaaa caggtaaata
    17701 taaaaaatta ggtcttcttg ggcttctctt tatgggaagc ggaatgttcc tcctttccac
    17761 gatgaaccca gggactagtc atttaattct tggaggctac cttgctctta ccggcttcgg
    17821 acttgggttg tccttatccc tatataatct cgtttcacag aattctgttc ctcaatctca
    17881 cttaggagtt gctacttccg ctagtcaact ttttcgacaa atgggaggaa ctatcggggt
    17941 atcgattatg ggtgggatca tgctcacccg aatgcagagt cggatcagct cttcgttagc
    18001 acaggcaccc gaatccttta gcaagttaac tgccttaaaa gatcctgaaa tcctcctttc
    18061 gccggataaa ctagcaacca tcaaggctga actgccagct aatttgaata cctcctttac
    18121 acaactcctc catcatttac gtgaggccat gggttttgcc ctcgatggag ttttcctgac
    18181 ggggtctggc atactggcat tcgcattcct cctagcttgc ttcctcaagg aaattccgct
    18241 cagaacaagt aattaggagg tccccgcaaa cgactctaga aaaaactacc cgtggttctt
    18301 atttcctcag caaaaagcga tccgttaaac agggtcgctt tttgttgagg aaataattaa
    18361 ttttatcttt gtgttaaata tcaccaagag aggaaagggg ggagttaaag ggtcctgtga
    18421 ttgaacgagc gaaaaaaact gtaggatcta tcatttttgc tttacaaagc tgcggctaaa
    18481 tcgacgaaat aaccaaggag agatagcaag caaaagagca cctccaagag aagcaaaaaa
    18541 gaccggggaa aacaaatcgt gtaaagaata ccctaagtaa ttaaagacaa aggctccagg
    18601 aagaactccg atcagtgtcc ccagataata gtcccttgcc cctgtacggg aaaatcccgc
    18661 tccataactt acagcatcaa agggaagaat ggggatcaaa cgcaggagga aaatggtgcg
    18721 aaatccctca tccaccatcc atttttccca acgagcataa ctacctaacc agcggctgac
    18781 tgtctccttt cccaaccatc gtgcaagagt aaaagccacc atcgccccgc caagggagcc
    18841 aatcacatcg agtatagttc cccaccatgg accaaaggta ataccagaag caacggctaa
    18901 gacaacagca ggaactaaaa ataatggccg cataacatgc atcagtagat aaaggatcgg
    18961 tgcccaaaca ccaaaggata agacaaaata ccgaatcgac tctgggctta attgtctcag
    19021 gtctaaaaaa aggaaaatac aagcaccaag tgctagaagg attagcaata atattatgga
    19081 caaatttttc ttgatcacca tttacccaca cttcctctca agcacagcct cttcagtatt
    19141 atcccctatc cccactaaat ccttcctttt ccttttaata tctaaattgg cac
//
